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Aliases for PLEK2 Gene

Aliases for PLEK2 Gene

  • Pleckstrin 2 2 3 5
  • Pleckstrin 2 Homolog 3
  • Pleckstrin-2 3

External Ids for PLEK2 Gene

Previous GeneCards Identifiers for PLEK2 Gene

  • GC14M065358
  • GC14M061647
  • GC14M065843
  • GC14M066923
  • GC14M067853
  • GC14M048023

Summaries for PLEK2 Gene

Entrez Gene Summary for PLEK2 Gene

  • The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]

GeneCards Summary for PLEK2 Gene

PLEK2 (Pleckstrin 2) is a Protein Coding gene. Diseases associated with PLEK2 include Pyosalpinx. An important paralog of this gene is PLEK.

UniProtKB/Swiss-Prot for PLEK2 Gene

  • May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.

Gene Wiki entry for PLEK2 Gene

Additional gene information for PLEK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEK2 Gene

Genomics for PLEK2 Gene

Regulatory Elements for PLEK2 Gene

Enhancers for PLEK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H067356 1.4 ENCODE dbSUPER 18.5 +53.0 52982 5.4 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ATP6V1D PLEK2 ZFYVE26 ENSG00000258561 GPHN EIF2S1 ENSG00000199755
GH14H067268 1 Ensembl ENCODE 17.8 +142.3 142346 3.6 PKNOX1 MAX ZNF384 RFX5 ZNF316 POLR2A ZNF600 PRDM10 MAFK RFX1 ATP6V1D PLEK2 MPP5 EIF2S1 GPHN GC14M067260 GC14M067261 GC14P067341
GH14H067263 1 ENCODE dbSUPER 17.8 +148.6 148647 0.8 FEZF1 ZNF664 ZNF121 GATA3 GLI2 SCRT2 ZNF600 PRDM10 SCRT1 OVOL3 ATP6V1D PLEK2 GC14M067260 GC14M067261 GC14P067341
GH14H066506 1.1 ENCODE 11.9 +903.8 903820 3.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766 FAM71D LINC02290 NCOA4P1 ATP6V1D PLEK2 EIF2S1 ENSG00000258561 GPHN
GH14H067409 1.2 Ensembl ENCODE 9.1 -0.2 -161 5.6 PKNOX1 ATF1 SIN3A GLIS2 ELK1 ATF7 FOS DEK REST SMARCB1 ATP6V1D PLEKHH1 PLEK2 MIR5694
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLEK2 on UCSC Golden Path with GeneCards custom track

Promoters for PLEK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069876 200 801 GTF2F1 PKNOX1 NFIB MAX SIN3A RFX5 E2F1 POLR2A ELK1 E2F6

Genomic Locations for PLEK2 Gene

Genomic Locations for PLEK2 Gene
26,542 bases
Minus strand

Genomic View for PLEK2 Gene

Genes around PLEK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEK2 Gene

Proteins for PLEK2 Gene

  • Protein details for PLEK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q96JT0

    Protein attributes for PLEK2 Gene

    353 amino acids
    Molecular mass:
    39971 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLEK2 Gene

neXtProt entry for PLEK2 Gene

Post-translational modifications for PLEK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLEK2 Gene

No data available for DME Specific Peptides for PLEK2 Gene

Domains & Families for PLEK2 Gene

Gene Families for PLEK2 Gene

Suggested Antigen Peptide Sequences for PLEK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLEK2: view

No data available for UniProtKB/Swiss-Prot for PLEK2 Gene

Function for PLEK2 Gene

Molecular function for PLEK2 Gene

GENATLAS Biochemistry:
pleckstrin 2 mouse homolog,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.

Phenotypes From GWAS Catalog for PLEK2 Gene

Gene Ontology (GO) - Molecular Function for PLEK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA --
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding IEA --
genes like me logo Genes that share ontologies with PLEK2: view
genes like me logo Genes that share phenotypes with PLEK2: view

miRNA for PLEK2 Gene

miRTarBase miRNAs that target PLEK2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEK2 Gene

Localization for PLEK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLEK2 Gene

Cell projection, lamellipodium membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEK2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLEK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031258 lamellipodium membrane IEA --
genes like me logo Genes that share ontologies with PLEK2: view

Pathways & Interactions for PLEK2 Gene

SuperPathways for PLEK2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLEK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization IEA --
GO:0031346 positive regulation of cell projection organization IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PLEK2: view

No data available for Pathways by source and SIGNOR curated interactions for PLEK2 Gene

Drugs & Compounds for PLEK2 Gene

(1) Additional Compounds for PLEK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLEK2: view

Transcripts for PLEK2 Gene

Unigene Clusters for PLEK2 Gene

Pleckstrin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP2: - - -
SP3: -

Relevant External Links for PLEK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLEK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLEK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLEK2 Gene

This gene is overexpressed in Adrenal Gland (x9.5), Liver (x5.5), and Colon - Transverse (x4.7).

Protein differential expression in normal tissues from HIPED for PLEK2 Gene

This gene is overexpressed in Fetal testis (34.0), Testis (22.7), and Adrenal (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLEK2 Gene

Protein tissue co-expression partners for PLEK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLEK2 Gene:


SOURCE GeneReport for Unigene cluster for PLEK2 Gene:

genes like me logo Genes that share expression patterns with PLEK2: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEK2 Gene

Orthologs for PLEK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLEK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLEK2 34 33
  • 99.43 (n)
(Canis familiaris)
Mammalia PLEK2 33 34
  • 91.76 (n)
(Bos Taurus)
Mammalia PLEK2 34 33
  • 90.46 (n)
(Mus musculus)
Mammalia Plek2 34 16 33
  • 89.8 (n)
(Rattus norvegicus)
Mammalia Plek2 33
  • 89.24 (n)
(Monodelphis domestica)
Mammalia PLEK2 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia PLEK2 34
  • 79 (a)
(Gallus gallus)
Aves PLEK2 34 33
  • 73.9 (n)
(Anolis carolinensis)
Reptilia PLEK2 34
  • 75 (a)
(Danio rerio)
Actinopterygii plek2 33 34
  • 60.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
Species where no ortholog for PLEK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEK2 Gene

Gene Tree for PLEK2 (if available)
Gene Tree for PLEK2 (if available)

Paralogs for PLEK2 Gene

Paralogs for PLEK2 Gene

(4) SIMAP similar genes for PLEK2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PLEK2: view

Variants for PLEK2 Gene

Sequence variations from dbSNP and Humsavar for PLEK2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000170281 -- 67,409,110(+) TGGTA(A/T)CATGT intron-variant
rs1000221076 -- 67,408,615(+) CAACA(A/G)AGACA intron-variant
rs1000311255 -- 67,386,532(+) CAGAC(A/T)TTTCA intron-variant, downstream-variant-500B
rs1000371365 -- 67,396,234(+) ACTCC(A/G)GCTCC intron-variant
rs1000420788 -- 67,396,020(+) TCAAA(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEK2 Gene

Variant ID Type Subtype PubMed ID
nsv564961 CNV gain 21841781
nsv509539 CNV insertion 20534489
nsv470651 CNV gain 18288195
nsv456331 CNV gain 19166990
nsv1319 CNV deletion 18451855
nsv1318 CNV insertion 18451855
esv2751285 CNV gain 17911159
esv2748805 CNV deletion 23290073
esv2748804 CNV deletion 23290073
esv2661146 CNV deletion 23128226

Variation tolerance for PLEK2 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEK2 Gene

Disorders for PLEK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLEK2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • pyosalpingitis
- elite association - COSMIC cancer census association via MalaCards
Search PLEK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLEK2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PLEK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLEK2 Gene

Publications for PLEK2 Gene

  1. Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading. (PMID: 17658464) Hamaguchi N … Fukui Y (Biochemical and biophysical research communications 2007) 2 3 22 60
  2. Pleckstrin homology domains and the cytoskeleton. (PMID: 11911883) Lemmon MA … Abrams CS (FEBS letters 2002) 2 3 22 60
  3. PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization. (PMID: 17008542) Bach TL … Abrams CS (Blood 2007) 3 22 60
  4. Cloning, expression and chromosomal assignment of human pleckstrin 2. (PMID: 15865208) Inazu T … Miyamoto K (Molecular biology reports 2005) 3 22 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for PLEK2 Gene

Sources for PLEK2 Gene

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