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Aliases for PLEK Gene

Aliases for PLEK Gene

  • Pleckstrin 2 3
  • Platelet 47 KDa Protein 3 4
  • P47 3 4

External Ids for PLEK Gene

Previous GeneCards Identifiers for PLEK Gene

  • GC02P068726
  • GC02P068550
  • GC02P068566
  • GC02P068504
  • GC02P068445
  • GC02P068329

Summaries for PLEK Gene

GeneCards Summary for PLEK Gene

PLEK (Pleckstrin) is a Protein Coding gene. Diseases associated with PLEK include scott syndrome and amyotrophic lateral sclerosis type 2. Among its related pathways are Hemostasis and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include protein homodimerization activity and phosphatidylinositol-3,4-bisphosphate binding. An important paralog of this gene is PLEK2.

UniProtKB/Swiss-Prot for PLEK Gene

  • Major protein kinase C substrate of platelets

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEK Gene

Genomics for PLEK Gene

Regulatory Elements for PLEK Gene

Transcription factor binding sites by QIAGEN in the PLEK gene promoter:

Genomic Location for PLEK Gene

68,365,173 bp from pter
68,397,453 bp from pter
32,281 bases
Plus strand

Genomic View for PLEK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEK Gene

Proteins for PLEK Gene

  • Protein details for PLEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R9E8
    • Q53SU8
    • Q6FGM8
    • Q6FGQ1
    • Q8WV81

    Protein attributes for PLEK Gene

    350 amino acids
    Molecular mass:
    40125 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLEK Gene

neXtProt entry for PLEK Gene

Proteomics data for PLEK Gene at MOPED

Post-translational modifications for PLEK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLEK Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLEK Gene

Domains & Families for PLEK Gene

Gene Families for PLEK Gene

Suggested Antigen Peptide Sequences for PLEK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DEP domain.
  • Contains 1 DEP domain.
  • Contains 2 PH domains.
genes like me logo Genes that share domains with PLEK: view

Function for PLEK Gene

Molecular function for PLEK Gene

GENATLAS Biochemistry:
pleckstrin,platelet and leukocyte major protein C kinase substrate
UniProtKB/Swiss-Prot Function:
Major protein kinase C substrate of platelets

Gene Ontology (GO) - Molecular Function for PLEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IDA 8615792
GO:0005515 protein binding IPI 8999861
GO:0042803 protein homodimerization activity IDA 8694752
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA 15698571
genes like me logo Genes that share ontologies with PLEK: view
genes like me logo Genes that share phenotypes with PLEK: view

Animal Models for PLEK Gene

MGI Knock Outs for PLEK:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLEK Gene

Localization for PLEK Gene

Subcellular locations from

Jensen Localization Image for PLEK Gene COMPARTMENTS Subcellular localization image for PLEK gene
Compartment Confidence
cytosol 4
extracellular 4
plasma membrane 4
cytoskeleton 3
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
nucleus 2
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PLEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IDA 8694752
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0032587 ruffle membrane IDA 9060471
genes like me logo Genes that share ontologies with PLEK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLEK Gene

Pathways & Interactions for PLEK Gene

genes like me logo Genes that share pathways with PLEK: view

SIGNOR curated interactions for PLEK Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEP 2768345
GO:0002576 platelet degranulation TAS --
GO:0006904 vesicle docking involved in exocytosis ISS --
GO:0007229 integrin-mediated signaling pathway IDA 10995449
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with PLEK: view

Drugs & Compounds for PLEK Gene

(25) Drugs for PLEK Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved Pharma Channel blocker 971
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Epinephrine Approved Pharma 768
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor Cox inhibitor 97
methacholine Approved Pharma 0

(34) Additional Compounds for PLEK Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with PLEK: view

Transcripts for PLEK Gene

mRNA/cDNA for PLEK Gene

Unigene Clusters for PLEK Gene

Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLEK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEK Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: -
SP6: - -
SP7: - -

Relevant External Links for PLEK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLEK Gene

mRNA expression in normal human tissues for PLEK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLEK Gene

This gene is overexpressed in Whole Blood (x23.7).

Protein differential expression in normal tissues from HIPED for PLEK Gene

This gene is overexpressed in Platelet (33.8), Peripheral blood mononuclear cells (17.4), and Spleen (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLEK Gene

SOURCE GeneReport for Unigene cluster for PLEK Gene Hs.468840

genes like me logo Genes that share expression patterns with PLEK: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PLEK Gene

Orthologs for PLEK Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLEK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLEK 35
  • 91.52 (n)
  • 94.57 (a)
  • 95 (a)
(Canis familiaris)
Mammalia PLEK 35
  • 90.76 (n)
  • 94.29 (a)
  • 94 (a)
(Mus musculus)
Mammalia Plek 35
  • 88.19 (n)
  • 91.71 (a)
Plek 16
Plek 36
  • 92 (a)
(Pan troglodytes)
Mammalia PLEK 35
  • 99.33 (n)
  • 99.14 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Plek 35
  • 87.81 (n)
  • 91.71 (a)
(Monodelphis domestica)
Mammalia PLEK 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
-- 36
  • 84 (a)
(Gallus gallus)
Aves PLEK 35
  • 77.17 (n)
  • 81.95 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia PLEK 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plek 35
  • 71.18 (n)
  • 74.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69065 35
(Danio rerio)
Actinopterygii plek 35
  • 68.1 (n)
  • 68 (a)
zgc66013 35
plek 36
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for PLEK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEK Gene

Gene Tree for PLEK (if available)
Gene Tree for PLEK (if available)

Paralogs for PLEK Gene

Paralogs for PLEK Gene

(1) SIMAP similar genes for PLEK Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLEK: view

Variants for PLEK Gene

Sequence variations from dbSNP and Humsavar for PLEK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6895 -- 68,397,212(+) ATTTT(C/T)CCTCA utr-variant-3-prime
rs8761 -- 68,397,128(+) TTGAA(A/G)CAGAT utr-variant-3-prime
rs964934 -- 68,384,745(+) TGAGC(A/G)TGGAT intron-variant
rs964935 -- 68,385,152(+) AGTAC(A/G)TATTT intron-variant
rs1016349 -- 68,374,855(-) ACAAC(C/T)TAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLEK Gene

Variant ID Type Subtype PubMed ID
nsv874250 CNV Loss 21882294

Variation tolerance for PLEK Gene

Residual Variation Intolerance Score: 79.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.36; 96.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLEK Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEK Gene

Disorders for PLEK Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLEK Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
scott syndrome
  • platelet factor x receptor deficiency
amyotrophic lateral sclerosis type 2
  • amyotrophic lateral sclerosis 2, juvenile
myopathy, centronuclear
  • centronuclear myopathy, autosomal, modifier of
- elite association
Search PLEK in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLEK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PLEK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLEK Gene

Publications for PLEK Gene

  1. Odorant-stimulated phosphoinositide signaling in mammalian olfactory receptor neurons. (PMID: 19781634) Klasen K. … Ache B.W. (Cell. Signal. 2010) 23 67
  2. Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity. (PMID: 20226764) Kabuta T. … Takahashi S. (Biochem. Biophys. Res. Commun. 2010) 23 67
  3. Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation. (PMID: 19920149) Seong H.A. … Ha H. (J. Biol. Chem. 2010) 23 67
  4. AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling. (PMID: 19948740) Wan T. … Min W. (J. Biol. Chem. 2010) 23 67
  5. Physiological regulation of Akt activity and stability. (PMID: 20182580) Liao Y. … Hung M.C. (Am J Transl Res 2010) 23 67

Products for PLEK Gene

Sources for PLEK Gene

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