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Aliases for PLD5 Gene

Aliases for PLD5 Gene

  • Phospholipase D Family, Member 5 2 3
  • Inactive Phosphatidylcholine-Hydrolyzing Phospholipase D5 3 4
  • Inactive Choline Phosphatase 5 3 4
  • Inactive PLD 5 3 4
  • PLDC 3 4
  • Inactive Phospholipase D5 3
  • CIDEC 6
  • FSP27 6
  • CIDE3 6
  • F 6

External Ids for PLD5 Gene

Summaries for PLD5 Gene

GeneCards Summary for PLD5 Gene

PLD5 (Phospholipase D Family, Member 5) is a Protein Coding gene. An important paralog of this gene is PLD4.

Gene Wiki entry for PLD5 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLD5 Gene

Genomics for PLD5 Gene

Genomic Location for PLD5 Gene

Start:
242,082,986 bp from pter
End:
242,524,696 bp from pter
Size:
441,711 bases
Orientation:
Minus strand

Genomic View for PLD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLD5 Gene

Regulatory Elements for PLD5 Gene

Proteins for PLD5 Gene

  • Protein details for PLD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7P1-PLD5_HUMAN
    Recommended name:
    Inactive phospholipase D5
    Protein Accession:
    Q8N7P1
    Secondary Accessions:
    • A1KXV0
    • B7Z324
    • Q494U9
    • Q8NB22

    Protein attributes for PLD5 Gene

    Size:
    536 amino acids
    Molecular mass:
    61312 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01374.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI01375.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI01376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLD5 Gene

Proteomics data for PLD5 Gene at MOPED

Post-translational modifications for PLD5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys194
  • Glycosylation at Asn121 and Asn302

No data available for DME Specific Peptides for PLD5 Gene

Domains for PLD5 Gene

Protein Domains for PLD5 Gene

UniProtKB/Swiss-Prot:

PLD5_HUMAN
Domain:
  • Contains 2 PLD phosphodiesterase domains.:
    • Q8N7P1
Family:
  • Belongs to the phospholipase D family.:
    • Q8N7P1
genes like me logo Genes that share domains with PLD5: view

No data available for Gene Families for PLD5 Gene

Function for PLD5 Gene

Gene Ontology (GO) - Molecular Function for PLD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with PLD5: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLD5 Gene

Localization for PLD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLD5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLD5 Gene COMPARTMENTS Subcellular localization image for PLD5 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLD5: view

Pathways for PLD5 Gene

SuperPathways for PLD5 Gene

No Data Available

Interacting Proteins for PLD5 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000440896%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000365895%0d%0a9606.ENSP00000429473%0d%0a9606.ENSP00000259241%0d%0a
Selected Interacting proteins: ENSP00000440896 for PLD5 Gene via STRING

Gene Ontology (GO) - Biological Process for PLD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PLD5: view

No data available for Pathways by source for PLD5 Gene

Compounds for PLD5 Gene

(1135) HMDB Compounds for PLD5 Gene

Compound Synonyms Cas Number PubMed IDs
PC(14:0/14:0)
  • Phosphatidylcholine(14:0/14:0)
Not Available
PC(14:0/14:1(9Z))
  • Phosphatidylcholine(14:0/14:1)
Not Available
PC(14:0/15:0)
  • GPCho(14:0/15:0)
Not Available
PC(14:0/16:0)
  • GPCho(30:0)
Not Available
PC(14:0/16:1(9Z))
  • 1-myristoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine
Not Available
genes like me logo Genes that share compounds with PLD5: view

Transcripts for PLD5 Gene

Unigene Clusters for PLD5 Gene

Phospholipase D family, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLD5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for PLD5 Gene

GeneLoc Exon Structure for
PLD5
ECgene alternative splicing isoforms for
PLD5

Expression for PLD5 Gene

mRNA expression in normal human tissues for PLD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLD5 Gene

This gene is overexpressed in Artery - Aorta (8.9) and Brain - Cerebellar Hemisphere (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLD5 Gene

SOURCE GeneReport for Unigene cluster for PLD5 Gene Hs.672452

genes like me logo Genes that share expressions with PLD5: view

Orthologs for PLD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLD5 36
  • 99.5 (n)
  • 99.63 (a)
PLD5 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLD5 36
  • 93.06 (n)
  • 95.87 (a)
PLD5 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLD5 36
  • 91.97 (n)
  • 95.35 (a)
PLD5 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pld5 36
  • 88.99 (n)
  • 94.22 (a)
Pld5 16
Pld5 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLD5 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLD5 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pld5 36
  • 89.86 (n)
  • 94.78 (a)
chicken
(Gallus gallus)
Aves PLD5 36
  • 76.75 (n)
  • 78.1 (a)
PLD5 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLD5 37
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01084700.1 37
  • 37 (a)
OneToMany
LOC100535478 36
  • 57.99 (n)
  • 52.95 (a)
PLD5 (1 of 2) 37
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43345 37
  • 29 (a)
ManyToMany
CG9248 37
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T05C3.6 37
  • 24 (a)
ManyToMany
Species with no ortholog for PLD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLD5 Gene

ENSEMBL:
Gene Tree for PLD5 (if available)
TreeFam:
Gene Tree for PLD5 (if available)

Paralogs for PLD5 Gene

Paralogs for PLD5 Gene

Selected SIMAP similar genes for PLD5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PLD5: view

Variants for PLD5 Gene

Sequence variations from dbSNP and Humsavar for PLD5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs167585 -- 242,183,643(+) gtaat(C/T)ccagc intron-variant
rs167586 -- 242,277,589(-) GTATT(A/G)GACTT intron-variant
rs172738 -- 242,184,050(+) gttac(G/T)cacta intron-variant
rs178428 -- 242,190,711(+) acctc(A/G)tctct intron-variant
rs184361 -- 242,157,112(+) cttca(A/G)tctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLD5 Gene

Variant ID Type Subtype PubMed ID
nsv873372 CNV Gain 21882294
dgv16e55 CNV Gain 17911159
nsv508703 CNV Loss 20534489
nsv468672 CNV Gain 19166990
nsv470788 CNV Gain 18288195
nsv528016 CNV Gain 19592680
esv2726296 CNV Deletion 23290073
esv2726307 CNV Deletion 23290073
esv2726318 CNV Deletion 23290073
esv1038787 CNV Insertion 17803354
esv1676362 CNV Deletion 17803354
esv998850 CNV Insertion 20482838
nsv515604 CNV Loss 19592680
esv1979417 CNV Deletion 18987734
nsv873375 CNV Gain 21882294
esv992990 CNV Insertion 20482838
esv2726329 CNV Deletion 23290073
esv998142 CNV Gain 20482838
esv25405 CNV Gain 19812545
esv2726340 CNV Deletion 23290073
esv2089690 CNV Deletion 18987734
nsv5077 CNV Loss 18451855
esv1505070 CNV Deletion 17803354
nsv873376 CNV Gain 21882294
esv2726351 CNV Deletion 23290073
esv2726363 CNV Deletion 23290073
esv2658863 CNV Deletion 23128226
esv270123 CNV Insertion 20981092
esv2658344 CNV Deletion 23128226
nsv873377 CNV Gain 21882294
nsv160878 CNV Insertion 16902084
esv1006418 CNV Insertion 20482838
esv1110378 CNV Insertion 17803354
nsv5088 CNV Loss 18451855
nsv873378 CNV Gain 21882294
nsv159213 CNV Insertion 16902084

Relevant External Links for PLD5 Gene

HapMap Linkage Disequilibrium report
PLD5

Disorders for PLD5 Gene

(1) OMIM Diseases for PLD5 Gene (612120)

Relevant External Links for PLD5

Genetic Association Database (GAD)
PLD5
Human Genome Epidemiology (HuGE) Navigator
PLD5
genes like me logo Genes that share disorders with PLD5: view

No data available for UniProtKB/Swiss-Prot for PLD5 Gene

Publications for PLD5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PMID: 19626040) McCauley J.L. … Haines J.L. (Genes Immun. 2009) 3 49
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. A genome-wide scan for common alleles affecting risk for autism. (PMID: 20663923) Anney R. … Hallmayer J. (Hum. Mol. Genet. 2010) 3 49
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for PLD5 Gene

Sources for PLD5 Gene

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