Aliases for PLD3 Gene
External Ids for PLD3 Gene
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
GeneCards Summary for PLD3 Gene
PLD3 (Phospholipase D Family, Member 3) is a Protein Coding gene. Diseases associated with PLD3 include alzheimer disease 19, late onset and alzheimer disease. Among its related pathways are Development FGFR signaling pathway and GPCR Pathway. GO annotations related to this gene include phospholipase D activity and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD5.
UniProtKB/Swiss-Prot for PLD3 Gene
Probably involved in APP processing.