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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLD3 Gene

protein-coding   GIFtS: 52
GCID: GC19P040854

phospholipase D family, member 3

(Previous name: phospholipase D3 )
 Explore 4 diseases affiliated with
PLD3 via our new
 Human Malady Compendium 
Biological research products
for PLD3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Phospholipase D Family, Member 31 2     PLD 32 3
HU-K41 2     EC 3.1.4.43 8
Phospholipase D31 2     HUK42
Choline Phosphatase 32 3     Hu-K43
HindIII K4L Homolog2 3     EC 3.1.48
Phosphatidylcholine-Hydrolyzing Phospholipase D32 3     

External Ids:    HGNC: 171581   Entrez Gene: 236462   Ensembl: ENSG000001052237   UniProtKB: Q8IV083   

Export aliases for PLD3 gene to outside databases

Previous GC identifers: GC19P041505 GC19P041257 GC19P045530 GC19P045546 GC19P045557 GC19P037290


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLD3 gene promoter:
         Max1   Pax-5   CBF-C   AREB6   CP2   CBF-A   CBF-B   CP1A   c-Myc   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

PLD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLD3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P040854:  view genomic region     (about GC identifiers)

Start:
40,854,332 bp from pter      End:
40,886,346 bp from pter
Size:
32,015 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLD3_HUMAN, Q8IV08 (See protein sequence)
Recommended Name: Phospholipase D3  
Size: 490 amino acids; 54705 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Sequence caution: Sequence=AAB16799.1; Type=Frameshift; Positions=52;
Secondary accessions: Q92853 Q9BW87

Explore the universe of human proteins at neXtProt for PLD3: NX_Q8IV08

Post-translational modifications:

  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IV08

  • 4/15 DME Specific Peptides for PLD3 (Q8IV08) (see all 15)
     LARDLTK  YNCSCLA  KIFEAYW  LVESIPE 

    PLD3 Protein expression data from MOPED and PaxDb:    About this image 
    PLD3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001026866.1  NP_036400.2  

    ENSEMBL proteins: 
     ENSP00000375886   ENSP00000386293   ENSP00000387050   ENSP00000348901   ENSP00000386938  
     ENSP00000387022   ENSP00000352220  
    Reactome Protein details: Q8IV08
    Human Recombinant Protein Products for PLD3: 
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    Uscn Proteins for PLD3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    PLD3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PLD3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001736 PLipase_D/transphosphatidylase

    Graphical View of Domain Structure for InterPro Entry Q8IV08

    ProtoNet protein and cluster: Q8IV08

    1 Blocks protein family: IPB013582 Phospholipase D/viral envelope

    UniProtKB/Swiss-Prot: PLD3_HUMAN, Q8IV08
    Similarity: Belongs to the phospholipase D family
    Similarity: Contains 2 PLD phosphodiesterase domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLD3_HUMAN, Q8IV08
    Catalytic activity: A phosphatidylcholine + H(2)O = choline + a phosphatidate

         Enzyme Numbers (IUBMB): EC 3.1.4.41 2 EC 3.1.42

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004630phospholipase D activity IEA--
    GO:0005515protein binding IPI--
    GO:0070290NAPE-specific phospholipase D activity IEA--
         
    PLD3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PLD3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    Immune System1.00
    Innate Immune System0.46
    2choline biosynthesis III
    choline biosynthesis III1.00
    Synthesis of PG0.45
    3Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis1.00
    Phospholipid metabolism0.64
    4Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34
    5G-AlphaQ Signaling
    G-AlphaQ Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLD3 (see all 8)
        FGF Pathway
    Endothelin-1 Signaling Pathway
    Antioxidant Action of Vitamin-C
    Sperm Motility
    Phospholipase-C Pathway

    2 BioSystems Pathways for PLD3 
        phospholipases
    choline biosynthesis III

    5/9        Reactome Pathways for PLD3 (see all 9)
        Metabolism
    Fcgamma receptor (FCGR) dependent phagocytosis
    Phospholipid metabolism
    Synthesis of PG
    Glycerophospholipid biosynthesis



    PLD3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLD3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/15 Interacting proteins for PLD3 (Q8IV081, 2, 3 ENSP000003489014) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA7P200732, 3MINT-8248611 I2D: score=2 
    BCL2L1Q078172, 3MINT-8249344 I2D: score=2 
    TK1P041832, 3MINT-8273895 I2D: score=2 
    NFKB1P198381, 3EBI-2689908,EBI-300010 I2D: score=1 
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006655phosphatidylglycerol biosynthetic process TAS--
    GO:0016042lipid catabolic process IEA--
    GO:0044281small molecule metabolic process TAS--
    GO:0046474glycerophospholipid biosynthetic process TAS--

    PLD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PLD3

    10/2211 HMDB Compounds for PLD3 (see all 2211)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--
    PC(14:0/14:0)Phosphatidylcholine(14:0/14:0) (see all 8)----
    PC(14:0/14:1(9Z))Phosphatidylcholine(14:0/14:1) (see all 14)----
    PC(14:0/15:0)GPCho(14:0/15:0) (see all 8)----
    PC(14:0/16:0)GPCho(30:0) (see all 8)----
    Search CenterWatch for drugs/clinical trials and news about PLD3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLD3 gene (2 alternative transcripts): 
    NM_001031696.2  NM_012268.2  

    Unigene Cluster for PLD3:

    Phospholipase D family, member 3
    Hs.257008  [show with all ESTs]
    Unigene Representative Sequence: BX648310
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392032(uc021uus.1) ENST00000409419 ENST00000409587(uc002onj.4)
    ENST00000356508(uc002onm.4) ENST00000409735 ENST00000409281(uc002onn.3)
    ENST00000493006 ENST00000359274 ENST00000464586 ENST00000485448(uc002ono.3)
    ENST00000492243 ENST00000480030 ENST00000475983 ENST00000488311 ENST00000486134


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    hsa-let-7d hsa-miR-501-3p hsa-let-7c hsa-miR-502-3p hsa-let-7g hsa-miR-654-5p hsa-let-7a hsa-miR-98
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    Additional cDNA sequence: 

    AK293690.1 AY927565.1 BC000553.1 BC036327.1 BC096820.1 BX648310.1 U60644.1 

    24/51 DOTS entries (see all 51):

    DT.95084317  DT.454104  DT.95378917  DT.95137453  DT.95191969  DT.100885916  DT.100885897  DT.91707908 
    DT.91781077  DT.100885908  DT.100885927  DT.100885924  DT.40190199  DT.95306207  DT.100885931  DT.100885893 
    DT.100885912  DT.100885892  DT.100885917  DT.100885926  DT.95084318  DT.100059548  DT.121470311  DT.121470326 

    24/908 AceView cDNA sequences (see all 908):

    BI772082 BI836173 BM723733 BM474238 BQ672113 BM783559 CB529596 BC000553 
    BU930975 AA947590 CD107465 BI094219 AI460131 BM745661 BQ895940 CA438205 
    BG742596 BE612965 BQ232908 CR617265 BM469014 BM556663 BE562445 BM702757 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for PLD3 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
    SP1:                          -     -                             -     -                       -                                                               
    SP2:                                -     -     -     -     -     -     -                       -                                                               
    SP3:                    -     -     -     -     -     -     -     -     -                       -                                                               
    SP4:                                                              -     -                 -     -     -     -     -                                             
    SP5:                          -     -     -     -     -     -     -                             -                                                               

    ExUns: 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:              -                                             
    SP2:              -                                             
    SP3:                                                            
    SP4:  -           -                                             
    SP5:                                                            


    ECgene alternative splicing isoforms for PLD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    PLD3 Expression
    About this image
    See PLD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLD3

    SOURCE GeneReport for Unigene cluster: Hs.257008

    UniProtKB/Swiss-Prot: PLD3_HUMAN, Q8IV08
    Tissue specificity: Widely expressed. Expressed at higher level in brain. Expressed at low level in corpus callosum,
    suggesting that it is highly expressed in neurons

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PLD3 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pld31 , 5 phospholipase D family, member 31, 5 88.18(n)1
    93.65(a)1
      7 (15.92 cM)5
    188071  NM_011116.11  NP_035246.11 
     275320005 
    lizard
    (Anolis carolinensis)
    Reptilia PLD36
    --
    53(a)
    1 ↔ 1
    LGf(2222068-2249503)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686762 hypothetical protein MGC68676 74.04(n)    BC059981.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pld31 phospholipase D family, member 3 63.72(n)
    59.6(a)
      571938  XM_003200490.1  XP_003200538.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92481 CG9248 54.55(n)
    50(a)
      35384  NM_136249.1  NP_610093.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F09G2.81 Protein F09G2.8 47.28(n)
    43.31(a)
      179105  NM_072423.5  NP_504824.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06499001 hypothetical protein 41.9(n)
    31.88(a)
      4341683  NM_001064755.1  NP_001058220.1 


    ENSEMBL Gene Tree for PLD3 (if available)
    TreeFam Gene Tree for PLD3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLD3 gene
    PLD52  PLD42  
    2 SIMAP similar genes for PLD3 using alignment to 13 protein entries:     PLD3_HUMAN (see all proteins):
    PLD4    PLD5

    PLD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/573 NCBI SNPs in PLD3 are shown (see all 573    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860347881,2
    --40852403(+) AAAATA/TAAAAA 5 -- int1 us2k10--------
    rs1478049721,2
    --40852430(+) AAAAAA/GAGAGG 5 -- int1 us2k10--------
    rs1892351611,2
    --40852485(+) CTGGAC/GTGCAG 5 -- us2k1 int10--------
    rs1813374541,2
    --40852524(+) TGCCTC/TCCAGG 5 -- us2k1 int10--------
    rs621076311,2
    C,F--40852680(+) CGCCCG/ATCTCG 5 -- int1 us2k12Minor allele frequency- A:0.50NA 4
    rs590492461,2
    C--40852827(+) ATGTT-/CGAAGTG 5 -- int1 us2k10--------
    rs1861647261,2
    --40852831(+) TTAAGC/TGTGCA 5 -- us2k1 int10--------
    rs1914529571,2
    --40852832(+) TAAGTA/GTGCAT 5 -- int1 us2k10--------
    rs1465138881,2
    --40852851(+) ACAAAC/TCTTCA 5 -- int1 us2k10--------
    rs1824306041,2
    --40853022(+) ATACGC/TAGTAT 5 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for PLD3 (40854332 - 40886346 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PLD3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLD3
    DNA2.0 Custom Variant and Variant Library Synthesis for PLD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PLD3 for disorders           About GeneDecksing

    4 diseases for PLD3:    About MalaCards
    corpus callosum    vaccinia    breast cancer    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: PLD3 (2 documents)

    Export disorders for PLD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLD3 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with PLD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum. (PubMed id 15794758)1, 2, 3, 9 Munck A....Hampe W. (2005)
    2. A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily. (PubMed id 9140189)1, 2, 3 Cao J.X.... Upton C. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. [Over-expression of phospholipase D3 inhibits Akt pho sphorylation in C2C12 myoblasts] (PubMed id 20112697)1, 9 Zhang J....Wang H. (2009)
    5. A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23646 HGNC: 17158 AceView: PLD3 Ensembl:ENSG00000105223 euGenes: HUgn23646
    ECgene: PLD3 H-InvDB: PLD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLD3 gene:
    Search GeneIP for patents involving PLD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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