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PLD3 Gene

protein-coding   GIFtS: 60
GCID: GC19P040854

Phospholipase D Family, Member 3

(Previous name: phospholipase D3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase D Family, Member 31 2     EC 3.1.4.43 8
Phospholipase D31 2     AD192 5
Choline Phosphatase 32 3     HUK42 5
HindIII K4L Homolog2 3     HU-K42
Phosphatidylcholine-Hydrolyzing Phospholipase D32 3     Hu-K43
PLD 32 3     EC 3.1.48

External Ids:    HGNC: 171581   Entrez Gene: 236462   Ensembl: ENSG000001052237   OMIM: 6156985   UniProtKB: Q8IV083   

Export aliases for PLD3 gene to outside databases

Previous GC identifers: GC19P041505 GC19P041257 GC19P045530 GC19P045546 GC19P045557 GC19P037290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLD3 Gene:
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane
phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD
phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in
this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same
protein have been found for this gene. (provided by RefSeq, Apr 2014)

GeneCards Summary for PLD3 Gene:
PLD3 (phospholipase D family, member 3) is a protein-coding gene. Diseases associated with PLD3 include vaccinia, and malaria. GO annotations related to this gene include phospholipase D activity and NAPE-specific phospholipase D activity. An important paralog of this gene is PLD5.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLD3 gene promoter:
         Max1   Pax-5   CBF-C   AREB6   CP2   CBF-A   CBF-B   CP1A   c-Myc   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLD3 promoter sequence
   Search Chromatin IP Primers for PLD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

PLD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLD3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P040854:  view genomic region     (about GC identifiers)

Start:
40,854,332 bp from pter      End:
40,886,346 bp from pter
Size:
32,015 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PLD3_HUMAN, Q8IV08 (See protein sequence)
Recommended Name: Phospholipase D3  
Size: 490 amino acids; 54705 Da
Sequence caution: Sequence=AAB16799.1; Type=Frameshift; Positions=52;
Secondary accessions: Q92853 Q9BW87

Explore the universe of human proteins at neXtProt for PLD3: NX_Q8IV08

Explore proteomics data for PLD3 at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Ubiquitination2 at Lys11, Lys157, Lys309
  • Glycosylation2 at Asn97, Asn132, Asn236, Asn387
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PLD3 (Q8IV08) (see all 15)
     LARDLTK  YNCSCLA  KIFEAYW  LVESIPE 


    See PLD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001026866.1  NP_001278240.1  NP_036400.2  

    ENSEMBL proteins: 
     ENSP00000469675   ENSP00000375886   ENSP00000470603   ENSP00000386293   ENSP00000387050  
     ENSP00000468999   ENSP00000386938   ENSP00000472509   ENSP00000348901   ENSP00000468898  
     ENSP00000471838   ENSP00000387022   ENSP00000352220   ENSP00000469868   ENSP00000472854  
     ENSP00000470569   ENSP00000473218  
    Reactome Protein details: Q8IV08

    PLD3 Human Recombinant Protein Products:

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    Novus Biologicals PLD3 Protein
    Novus Biologicals PLD3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLD3

    PLD3 Antibody Products:

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    ThermoFisher Antibodies for PLD3
    LSBio Antibodies in human, mouse, rat for PLD3

    PLD3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PLD3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PLD3
    Cloud-Clone Corp. CLIAs for PLD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001736 PLipase_D/transphosphatidylase

    Graphical View of Domain Structure for InterPro Entry Q8IV08

    ProtoNet protein and cluster: Q8IV08

    1 Blocks protein domain: IPB013582 Phospholipase D/viral envelope

    UniProtKB/Swiss-Prot: PLD3_HUMAN, Q8IV08
    Similarity: Belongs to the phospholipase D family
    Similarity: Contains 2 PLD phosphodiesterase domains


    PLD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLD3_HUMAN, Q8IV08
    Catalytic activity: A phosphatidylcholine + H(2)O = choline + a phosphatidate

         Enzyme Numbers (IUBMB): EC 3.1.4.41 2 EC 3.1.42

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004630phospholipase D activity IEA--
    GO:0005515protein binding IPI--
    GO:0070290NAPE-specific phospholipase D activity IEA--
         
    PLD3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLD3:
    hsa-mir-484 (MIRT042303), hsa-mir-320a (MIRT044846), hsa-mir-335-5p (MIRT017099), hsa-mir-16-5p (MIRT051205), hsa-mir-877-5p (MIRT037314)

    Block miRNA regulation of human, mouse, rat PLD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLD3 (see all 19):
    hsa-let-7d hsa-miR-501-3p hsa-let-7c hsa-miR-502-3p hsa-let-7g hsa-miR-654-5p hsa-let-7a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidPLD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLD3
    Predesigned siRNA for gene silencing in human, mouse, rat PLD3

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLD3 (NM_012268)
    Sino Biological Human cDNA Clone for PLD3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLD3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PLD3
    Browse ESI BIO Cell Lines and PureStem Progenitors for PLD3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLD3_HUMAN, Q8IV08: Endoplasmic reticulum membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    PLD3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLD3 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Synthesis of PG0.00
    Phospholipid metabolism0.64
    choline biosynthesis III0.00
    Glycerophospholipid metabolism0.62
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Fcgamma receptor (FCGR) dependent phagocytosis
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    4GPCR Pathway
    Ras Pathway0.73
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLD3 (see all 8)
        FGF Pathway
    Endothelin-1 Signaling Pathway
    Antioxidant Action of Vitamin-C
    Sperm Motility
    Phospholipase-C Pathway

    2 BioSystems Pathways for PLD3
        choline biosynthesis III
    phospholipases


    2 Reactome Pathways for PLD3
        Synthesis of PG
    Role of phospholipids in phagocytosis


    3 Kegg Pathways  (Kegg details for PLD3):
        Glycerophospholipid metabolism
    Ether lipid metabolism
    Metabolic pathways


    PLD3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLD3
    Interactions:

        Search GeneGlobe Interaction Network for PLD3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for PLD3 (Q8IV081, 2, 3 ENSP000003489014) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA7P200732, 3MINT-8248611 I2D: score=2 
    BCL2L1Q078172, 3MINT-8249344 I2D: score=2 
    TK1P041832, 3MINT-8273895 I2D: score=2 
    NFKB1P198381, 3EBI-2689908,EBI-300010 I2D: score=1 
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006655phosphatidylglycerol biosynthetic process TAS--
    GO:0008152metabolic process ----
    GO:0016042lipid catabolic process IEA--
    GO:0044281small molecule metabolic process TAS--

    PLD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLD3

    Selected HMDB Compounds for PLD3 (see all 2211)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--
    PC(14:0/14:0)Phosphatidylcholine(14:0/14:0) (see all 8)----
    PC(14:0/14:1(9Z))Phosphatidylcholine(14:0/14:1) (see all 14)----
    PC(14:0/15:0)GPCho(14:0/15:0) (see all 8)----
    PC(14:0/16:0)GPCho(30:0) (see all 8)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PLD3 gene (3 alternative transcripts): 
    NM_001031696.3  NM_001291311.1  NM_012268.3  

    Unigene Cluster for PLD3:

    Phospholipase D family, member 3
    Hs.257008  [show with all ESTs]
    Unigene Representative Sequence: BX648310
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000599685 ENST00000600479 ENST00000392032(uc021uus.1) ENST00000598962
    ENST00000409419 ENST00000409587(uc002onj.4) ENST00000594085 ENST00000602131
    ENST00000409735 ENST00000600948 ENST00000356508(uc002onm.4) ENST00000596682
    ENST00000594908 ENST00000409281(uc002onn.3) ENST00000493006 ENST00000359274
    ENST00000464586 ENST00000485448(uc002ono.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PLD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLD3 (see all 19):
    hsa-let-7d hsa-miR-501-3p hsa-let-7c hsa-miR-502-3p hsa-let-7g hsa-miR-654-5p hsa-let-7a hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidPLD3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PLD3
    Predesigned siRNA for gene silencing in human, mouse, rat PLD3
    Clone
    Products:
         
    OriGene clones in human, mouse for PLD3 (see all 13)
    OriGene ORF clones in mouse, rat for PLD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLD3 (NM_012268)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLD3
    Primer
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    OriGene qPCR primer pairs and template standards for PLD3
    OriGene qSTAR qPCR primer pairs in human, mouse for PLD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLD3
      QuantiTect SYBR Green Assays in human, mouse, rat PLD3
      QuantiFast Probe-based Assays in human, mouse, rat PLD3

    Additional mRNA sequence: 

    AK293690.1 AY927565.1 BC000553.1 BC036327.1 BC096820.1 BX648310.1 U60644.1 

    Selected DOTS entries (see all 51):

    DT.95084317  DT.454104  DT.95378917  DT.95137453  DT.95191969  DT.100885916  DT.100885897  DT.91707908 
    DT.91781077  DT.100885908  DT.100885927  DT.100885924  DT.40190199  DT.95306207  DT.100885931  DT.100885893 
    DT.100885912  DT.100885892  DT.100885917  DT.100885926  DT.95084318  DT.100059548  DT.121470311  DT.121470326 

    Selected AceView cDNA sequences (see all 908):

    BM850531 CR594566 AJ574011 BI822237 BU737487 BE328427 BC000553 BQ232908 
    BI836173 CD107465 AA947590 BU855689 BM555932 CR595516 CR617265 BU846158 
    BM723733 BE612965 CF127089 H60992 BE562445 BM556663 AA069813 CD366503 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLD3 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
    SP1:                          -     -                             -     -                       -                                                               
    SP2:                                -     -     -     -     -     -     -                       -                                                               
    SP3:                    -     -     -     -     -     -     -     -     -                       -                                                               
    SP4:                                                              -     -                 -     -     -     -     -                                             
    SP5:                          -     -     -     -     -     -     -                             -                                                               

    ExUns: 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
    SP1:              -                                             
    SP2:              -                                             
    SP3:                                                            
    SP4:  -           -                                             
    SP5:                                                            


    ECgene alternative splicing isoforms for PLD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PLD3 Expression
    About this image


    PLD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    PLD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.257008

    UniProtKB/Swiss-Prot: PLD3_HUMAN, Q8IV08
    Tissue specificity: Widely expressed. Expressed at higher level in brain. Expressed at low level in corpus
    callosum, suggesting that it is highly expressed in neurons

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PLD3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pld31 , 5 phospholipase D family, member 31, 5 88.18(n)1
    93.65(a)1
      7 (15.92 cM)5
    188071  NM_011116.11  NP_035246.11 
     275320005 
    chicken
    (Gallus gallus)
    Aves PLD36
    phospholipase D family, member 3
    44(a)
    1 ↔ 1
    JH375692.1(3592-8361)
    lizard
    (Anolis carolinensis)
    Reptilia PLD36
    phospholipase D family, member 3
    53(a)
    1 ↔ 1
    LGf(2220353-2251354)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686762 hypothetical protein MGC68676 74.04(n)    BC059981.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pld31 phospholipase D family, member 3 63.72(n)
    59.6(a)
      571938  XM_003200490.2  XP_003200538.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92481 CG9248 54.62(n)
    50.13(a)
      35384  NM_165356.2  NP_724313.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F09G2.81 F09G2.8 47.28(n)
    43.31(a)
      179105  NM_001129433.2  NP_001122905.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06499001 Os06g0649900 41.56(n)
    31.88(a)
      4341683  NM_001064755.1  NP_001058220.1 


    ENSEMBL Gene Tree for PLD3 (if available)
    TreeFam Gene Tree for PLD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLD3 gene
    PLD52  PLD42  
    2 SIMAP similar genes for PLD3 using alignment to 13 protein entries:     PLD3_HUMAN (see all proteins):
    PLD4    PLD5

    PLD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLD3 (see all 626)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399494791,2
    --40856460(+) AGCCTA/GGACAA 2 -- int10--------
    rs1434991441,2
    --40856496(+) AAATGC/GAAAAA 2 -- int10--------
    rs768952411,2
    C--40856521(+) TGGCGC/TGCCCC 2 -- int14Minor allele frequency- T:0.15CSA WA NA EA 360
    rs1894782291,2
    --40856877(+) CGGTGA/GCTCAC 2 -- int10--------
    rs1467170961,2
    --40856951(+) ATCAGC/TCTGGG 2 -- int10--------
    rs1402738671,2
    C--40856961(+) GCAACA/TTAGCG 2 -- int10--------
    rs1503608461,2
    --40856970(+) CGAAAC/GCCCAT 2 -- int10--------
    rs1166992301,2
    F--40857104(+) ATACAC/TTCCAG 2 -- int11Minor allele frequency- T:0.01WA 118
    rs2016972781,2
    --40857149(+) AAAAA-/ACAAAAC 2 -- int10--------
    rs560518821,2
    C--40857150(+) AAAAA-/CAAAAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for PLD3 (40854332 - 40886346 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PLD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665673CNV Deletion23128226
    esv1638921CNV Insertion17803354
    dgv3867n71CNV Loss21882294
    nsv833831CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615698   
    OMIM disorders: 615711  
    5 diseases for PLD3:    
    About MalaCards
    vaccinia    malaria    cerebritis    breast cancer
    neuronitis


    PLD3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLD3
    Human Genome Epidemiology (HuGE) Navigator: PLD3 (2 documents)

    Export disorders for PLD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLD3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with PLD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum. (PubMed id 15794758)1, 2, 3, 9 Munck A.... Hampe W. (FEBS J. 2005)
    2. A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily. (PubMed id 9140189)1, 2, 3 Cao J.X.... Upton C. (Virus Res. 1997)
    3. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)1, 4 Walker L.C....Spurdle A.B. (Breast Cancer Res. Treat. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. [Over-expression of phospholipase D3 inhibits Akt phosphorylation in C2C12 myoblasts]. (PubMed id 20112697)1, 9 Zhang J....Wang H. (Sheng Wu Gong Cheng Xue Bao 2009)
    6. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. (PubMed id 24336208)1 Cruchaga C....Goate A.M. (Nature 2014)
    7. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    10. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (PubMed id 21752829)1 Palmieri M....Ballabio A. (Hum. Mol. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23646 HGNC: 17158 AceView: PLD3 Ensembl:ENSG00000105223 euGenes: HUgn23646
    ECgene: PLD3 Kegg: 23646 H-InvDB: PLD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLD3 gene:
    Search GeneIP for patents involving PLD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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