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Aliases for PLD3 Gene

Aliases for PLD3 Gene

  • Phospholipase D Family Member 3 2 3 5
  • Phosphatidylcholine-Hydrolyzing Phospholipase D3 3 4
  • Phospholipase D Family, Member 3 2 3
  • Choline Phosphatase 3 3 4
  • HindIII K4L Homolog 3 4
  • EC 4 63
  • HU-K4 3 4
  • Phospholipase D3 2
  • EC 3.1.4 63
  • PLD 3 4
  • AD19 3
  • HUK4 3

External Ids for PLD3 Gene

Previous GeneCards Identifiers for PLD3 Gene

  • GC19P041505
  • GC19P041257
  • GC19P045530
  • GC19P045546
  • GC19P045557
  • GC19P040854
  • GC19P037290

Summaries for PLD3 Gene

Entrez Gene Summary for PLD3 Gene

  • This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for PLD3 Gene

PLD3 (Phospholipase D Family Member 3) is a Protein Coding gene. Diseases associated with PLD3 include Alzheimer Disease 19, Late Onset and Alzheimer Disease. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Development FGFR signaling pathway. GO annotations related to this gene include phospholipase D activity and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD5.

UniProtKB/Swiss-Prot for PLD3 Gene

  • Probably involved in APP processing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLD3 Gene

Genomics for PLD3 Gene

Regulatory Elements for PLD3 Gene

Enhancers for PLD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLD3 on UCSC Golden Path with GeneCards custom track

Promoters for PLD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLD3 Gene

40,348,425 bp from pter
40,380,439 bp from pter
32,015 bases
Plus strand

Genomic View for PLD3 Gene

Genes around PLD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLD3 Gene

Proteins for PLD3 Gene

  • Protein details for PLD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipase D3
    Protein Accession:
    Secondary Accessions:
    • Q92853
    • Q9BW87

    Protein attributes for PLD3 Gene

    490 amino acids
    Molecular mass:
    54705 Da
    Quaternary structure:
    • Interacts with APP.
    • Sequence=AAB16799.1; Type=Frameshift; Positions=52; Evidence={ECO:0000305};

neXtProt entry for PLD3 Gene

Proteomics data for PLD3 Gene at MOPED

Post-translational modifications for PLD3 Gene

Domains & Families for PLD3 Gene

Gene Families for PLD3 Gene

Protein Domains for PLD3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 PLD phosphodiesterase domains.
  • Belongs to the phospholipase D family.
  • Contains 2 PLD phosphodiesterase domains.
  • Belongs to the phospholipase D family.
genes like me logo Genes that share domains with PLD3: view

Function for PLD3 Gene

Molecular function for PLD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A phosphatidylcholine + H(2)O = choline + a phosphatidate.
UniProtKB/Swiss-Prot Function:
Probably involved in APP processing.

Enzyme Numbers (IUBMB) for PLD3 Gene

genes like me logo Genes that share phenotypes with PLD3: view

Animal Models for PLD3 Gene

MGI Knock Outs for PLD3:
  • Pld3 tm1e(EUCOMM)Wtsi

Animal Model Products

miRNA for PLD3 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLD3 Gene

Localization for PLD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLD3 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for PLD3 Gene COMPARTMENTS Subcellular localization image for PLD3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for PLD3 Gene

Pathways & Interactions for PLD3 Gene

genes like me logo Genes that share pathways with PLD3: view

Interacting Proteins for PLD3 Gene

Gene Ontology (GO) - Biological Process for PLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006655 phosphatidylglycerol biosynthetic process TAS --
GO:0008152 metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PLD3: view

No data available for SIGNOR curated interactions for PLD3 Gene

Drugs & Compounds for PLD3 Gene

(2) Drugs for PLD3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra 139
Ethanolamine Experimental Pharma 0

(9) Additional Compounds for PLD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide hydroxide inner salt
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide inner salt
  • 1,2-Bis(hexadecanoyl)-sn-glycero-3-phosphocholine
  • 1,2-Bis(palmitoyl)-sn-glycero-3-phosphocholine
  • 1,2-Dihexadecanoyl-sn-glycerol-3-phosphorylcholine
63-89-8, 68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
genes like me logo Genes that share compounds with PLD3: view

Transcripts for PLD3 Gene

Unigene Clusters for PLD3 Gene

Phospholipase D family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - -
SP8: - -
SP10: - - - -
SP11: - - -
SP12: - -
SP13: - -
SP14: - - - -
SP16: -
SP17: - - -

ExUns: 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2: -
SP4: - -
SP9: -

Relevant External Links for PLD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLD3 Gene

mRNA expression in normal human tissues for PLD3 Gene

Protein differential expression in normal tissues from HIPED for PLD3 Gene

This gene is overexpressed in Amniocyte (16.3) and Adrenal (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLD3 Gene

SOURCE GeneReport for Unigene cluster for PLD3 Gene Hs.257008

mRNA Expression by UniProt/SwissProt for PLD3 Gene

Tissue specificity: Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum.
genes like me logo Genes that share expression patterns with PLD3: view

Protein tissue co-expression partners for PLD3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PLD3 Gene

Orthologs for PLD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLD3 35
  • 91.97 (n)
  • 96.33 (a)
PLD3 36
  • 96 (a)
(Canis familiaris)
Mammalia PLD3 35
  • 93.61 (n)
  • 97.35 (a)
PLD3 36
  • 97 (a)
(Mus musculus)
Mammalia Pld3 35
  • 88.18 (n)
  • 93.65 (a)
Pld3 16
Pld3 36
  • 94 (a)
(Pan troglodytes)
Mammalia PLD3 35
  • 99.7 (n)
  • 99.78 (a)
PLD3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pld3 35
  • 88.32 (n)
  • 94.26 (a)
(Monodelphis domestica)
Mammalia PLD3 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia PLD3 36
  • 54 (a)
(Gallus gallus)
Aves PLD3 36
  • 44 (a)
(Anolis carolinensis)
Reptilia PLD3 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pld3 35
  • 57.63 (n)
  • 55.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68676 35
(Danio rerio)
Actinopterygii pld3 35
  • 63.72 (n)
  • 59.6 (a)
pld3 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000199 35
  • 57.48 (n)
  • 48.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9248 35
  • 54.62 (n)
  • 50.13 (a)
CG43345 36
  • 37 (a)
CG9248 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea F09G2.8 35
  • 47.28 (n)
  • 43.31 (a)
F09G2.8 36
  • 32 (a)
(Oryza sativa)
Liliopsida Os06g0649900 35
  • 41.56 (n)
  • 31.88 (a)
Species with no ortholog for PLD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLD3 Gene

Gene Tree for PLD3 (if available)
Gene Tree for PLD3 (if available)

Paralogs for PLD3 Gene

Paralogs for PLD3 Gene

genes like me logo Genes that share paralogs with PLD3: view

Variants for PLD3 Gene

Sequence variations from dbSNP and Humsavar for PLD3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_071186 -
rs7258325 -- 40,365,552(+) GACTA(A/G)GTAAT intron-variant, splice-acceptor-variant
rs7258416 -- 40,365,598(+) AATGA(A/G)AAAAG intron-variant, utr-variant-5-prime
rs7258644 -- 40,367,270(+) TTTTT(A/T)AAAGA intron-variant
rs7258698 -- 40,367,057(+) CGCCC(A/G)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLD3 Gene

Variant ID Type Subtype PubMed ID
nsv833831 CNV Loss 17160897
dgv3867n71 CNV Loss 21882294
esv2665673 CNV Deletion 23128226
esv1638921 CNV Insertion 17803354

Variation tolerance for PLD3 Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLD3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLD3 Gene

Disorders for PLD3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PLD3 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease 19, late onset
  • late-onset alzheimer disease
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search PLD3 in MalaCards View complete list of genes associated with diseases


  • Alzheimer disease 19 (AD19) [MIM:615711]: A late-onset form of Alzheimer disease, a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. {ECO:0000269 PubMed:24336208, ECO:0000269 PubMed:25832409, ECO:0000269 PubMed:25832410}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Disease association is, however, under debate. Some studies support PLD3 involvement in Alzheimer disease (PubMed:24336208, PubMed:25832410 and PubMed:25832409), while others do not (Ref.8, Ref.11 and Ref.12). {ECO:0000269 PubMed:24336208, ECO:0000269 PubMed:25832408, ECO:0000269 PubMed:25832409, ECO:0000269 PubMed:25832410, ECO:0000269 PubMed:25832411, ECO:0000269 PubMed:25832413}.

Relevant External Links for PLD3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PLD3: view

No data available for Genatlas for PLD3 Gene

Publications for PLD3 Gene

  1. Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum. (PMID: 15794758) Munck A. … Hampe W. (FEBS J. 2005) 2 3 4 23 67
  2. [Over-expression of phospholipase D3 inhibits Akt phosphorylation in C2C12 myoblasts]. (PMID: 20112697) Zhang J. … Wang H. (Sheng Wu Gong Cheng Xue Bao 2009) 3 23
  3. A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily. (PMID: 9140189) Cao J.X. … Upton C. (Virus Res. 1997) 2 3
  4. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for PLD3 Gene

Sources for PLD3 Gene