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Aliases for PLD2 Gene

Aliases for PLD2 Gene

  • Phospholipase D2 2 3 5
  • Choline Phosphatase 2 2 3 4
  • Phosphatidylcholine-Hydrolyzing Phospholipase D2 3 4
  • EC 3.1.4.4 4 61
  • PLD1C 3 4
  • HPLD2 3 4
  • PLD 2 4

External Ids for PLD2 Gene

Previous GeneCards Identifiers for PLD2 Gene

  • GC17P005137
  • GC17P004661
  • GC17P004917
  • GC17P004657
  • GC17P004710
  • GC17P004598

Summaries for PLD2 Gene

Entrez Gene Summary for PLD2 Gene

  • The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PLD2 Gene

PLD2 (Phospholipase D2) is a Protein Coding gene. Diseases associated with PLD2 include Tooth Agenesis. Among its related pathways are Metabolism and Acyl chain remodelling of PE. GO annotations related to this gene include phosphatidylinositol binding and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD1.

UniProtKB/Swiss-Prot for PLD2 Gene

  • May have a role in signal-induced cytoskeletal regulation and/or endocytosis.

Tocris Summary for PLD2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLD2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLD2 Gene

Genomics for PLD2 Gene

Regulatory Elements for PLD2 Gene

Enhancers for PLD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F004847 1.5 FANTOM5 Ensembl ENCODE 12.9 +44.2 44240 7.9 PKNOX1 ZBTB40 RAD21 RFX5 RARA RCOR1 FOS THAP11 EGR2 ZNF263 CHRNE ENO3 ZMYND15 PFN1 ARRB2 C17orf107 RNF167 PLD2 CXCL16 LOC101559451
GH17F004795 1.1 ENCODE 16.7 -10.9 -10854 1.7 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS PLD2 LOC105371506 ENSG00000262165 NUP88 C17orf107 PSMB6
GH17F004806 1.1 ENCODE 15.3 +0.1 131 1.5 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 PLD2 ENSG00000262165 GC17M004737
GH17F004720 1.4 Ensembl ENCODE 12 -85.3 -85313 2.4 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 FOS PAF1 ZNF263 ARRB2 PLD2 MINK1 ALOX15 GGT6 ZFP3 GC17M004721
GH17F004856 1.3 Ensembl ENCODE 12.9 +51.7 51680 5.3 ATF1 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 FOS SP5 NFYC CHRNE C17orf107 ZFP3 MINK1 PLD2 ARRB2 LOC101559451 PELP1 RPS12P29 CXCL16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLD2 on UCSC Golden Path with GeneCards custom track

Promoters for PLD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001339621 -95 2000 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for PLD2 Gene

Chromosome:
17
Start:
4,807,096 bp from pter
End:
4,823,434 bp from pter
Size:
16,339 bases
Orientation:
Plus strand

Genomic View for PLD2 Gene

Genes around PLD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLD2 Gene

Proteins for PLD2 Gene

  • Protein details for PLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14939-PLD2_HUMAN
    Recommended name:
    Phospholipase D2
    Protein Accession:
    O14939
    Secondary Accessions:
    • I3L2C9
    • O43540
    • O43579
    • O43580
    • Q6PGR0
    • Q96BY3

    Protein attributes for PLD2 Gene

    Size:
    933 amino acids
    Molecular mass:
    105987 Da
    Quaternary structure:
    • Interacts with EGFR (By similarity). Interacts with PIP5K1B.

    Alternative splice isoforms for PLD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLD2 Gene

Selected DME Specific Peptides for PLD2 Gene

O14939:
  • IGSANIN
  • EYQAGRFA
  • INSGYSK
  • KEVELAL
  • YIENQFF
  • ARHFIQRWNFTK
  • LGKRDSE
  • EEIFITDWWLSPE
  • DFIDRET
  • KDWVQLD
  • LPGFEGDISTGGGN
  • DLAYGRWDD
  • VKDSFLLYM
  • LHPNIKVMRHPD
  • ASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPD
  • EGEDPADRMHP
  • AQVVGTERYTSGSKVGTCTLYSVRLTHGDF
  • LWAHHEKL
  • HPLVFAPGVPV
  • CYRWSKRWL

Post-translational modifications for PLD2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLD2 (PLD2)

Domains & Families for PLD2 Gene

Gene Families for PLD2 Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for PLD2 Gene

Graphical View of Domain Structure for InterPro Entry

O14939

UniProtKB/Swiss-Prot:

PLD2_HUMAN :
  • Contains 1 PH domain.
  • Belongs to the phospholipase D family.
Domain:
  • Contains 1 PH domain.
  • Contains 2 PLD phosphodiesterase domains.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the phospholipase D family.
genes like me logo Genes that share domains with PLD2: view

Function for PLD2 Gene

Molecular function for PLD2 Gene

GENATLAS Biochemistry:
phospholipase D2,106kDa,phosphatidylcholine specific,widely expressed,involved in metabolic regulation,cardiac and brain function,senescence regulated secretion,mitogenesis and cytoskeletal changes
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphatidylcholine + H(2)O = choline + a phosphatidate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation factor-1 (ARF-1).
UniProtKB/Swiss-Prot Function:
May have a role in signal-induced cytoskeletal regulation and/or endocytosis.

Enzyme Numbers (IUBMB) for PLD2 Gene

Gene Ontology (GO) - Molecular Function for PLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004630 phospholipase D activity IEA,TAS --
GO:0005515 protein binding IPI 16407827
GO:0016787 hydrolase activity IEA --
GO:0035091 phosphatidylinositol binding IEA --
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity IEA --
genes like me logo Genes that share ontologies with PLD2: view
genes like me logo Genes that share phenotypes with PLD2: view

Animal Models for PLD2 Gene

MGI Knock Outs for PLD2:

Animal Model Products

miRNA for PLD2 Gene

miRTarBase miRNAs that target PLD2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLD2 Gene

Localization for PLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLD2 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLD2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
nucleus 4
cytosol 4
golgi apparatus 4
extracellular 1
cytoskeleton 1
mitochondrion 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for PLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IBA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with PLD2: view

Pathways & Interactions for PLD2 Gene

genes like me logo Genes that share pathways with PLD2: view

SIGNOR curated interactions for PLD2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process IEA,TAS --
GO:0007010 cytoskeleton organization TAS 9395408
GO:0007264 small GTPase mediated signal transduction TAS 9582313
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLD2: view

Drugs & Compounds for PLD2 Gene

(24) Drugs for PLD2 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
Choline Approved Nutra Target, product of 148
Water Approved Pharma 0
Zinc Approved Pharma 2231
Ethanolamine Experimental Pharma 0

(45) Additional Compounds for PLD2 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
LPA(16:0/0:0)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate

(5) Tocris Compounds for PLD2 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
U 73343 Analog of U 73122 (Cat. No. 1268) 142878-12-4
VU 0155069 Potent and selective PLD1 inhibitor 1130067-06-9
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor 1244640-48-9
genes like me logo Genes that share compounds with PLD2: view

Transcripts for PLD2 Gene

Unigene Clusters for PLD2 Gene

Phospholipase D2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for PLD2 Gene

GeneLoc Exon Structure for
PLD2
ECgene alternative splicing isoforms for
PLD2

Expression for PLD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLD2 Gene

mRNA differential expression in normal tissues according to GTEx for PLD2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for PLD2 Gene

This gene is overexpressed in Platelet (25.7), Cervix (19.1), and Liver, secretome (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of PLD2 Gene:

PLD2

SOURCE GeneReport for Unigene cluster for PLD2 Gene:

Hs.104519

mRNA Expression by UniProt/SwissProt for PLD2 Gene:

O14939-PLD2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PLD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for PLD2 Gene

Orthologs for PLD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLD2 34 35
  • 98.71 (n)
cow
(Bos Taurus)
Mammalia PLD2 34 35
  • 90.35 (n)
rat
(Rattus norvegicus)
Mammalia Pld2 34
  • 87.5 (n)
mouse
(Mus musculus)
Mammalia Pld2 34 16 35
  • 87.17 (n)
dog
(Canis familiaris)
Mammalia PLD2 34 35
  • 84.82 (n)
oppossum
(Monodelphis domestica)
Mammalia PLD2 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLD2 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pld2 34
  • 64 (n)
zebrafish
(Danio rerio)
Actinopterygii pld2 34 35
  • 61.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pld 36 35
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea pld-1 36 35
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPO14 35 37
  • 18 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2078 34
corn
(Zea mays)
Liliopsida Zm.50 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for PLD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLD2 Gene

ENSEMBL:
Gene Tree for PLD2 (if available)
TreeFam:
Gene Tree for PLD2 (if available)

Paralogs for PLD2 Gene

Paralogs for PLD2 Gene

(1) SIMAP similar genes for PLD2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PLD2: view

Variants for PLD2 Gene

Sequence variations from dbSNP and Humsavar for PLD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_036503 A breast cancer sample
rs386352350 Uncertain significance 4,817,011(+) CGGCC(C/T)GGGAC intron-variant, nc-transcript-variant, reference, missense
rs1052742 -- 4,807,177(+) CCGTC(C/T)GCTCT intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1052746 -- 4,810,871(+) CTGGC(A/G)CAGGG nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1052748 -- 4,817,174(+) TCCCA(C/T)ATACC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLD2 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV loss 17160897
nsv833347 CNV loss 17160897
nsv820043 CNV loss 19587683
nsv574273 CNV gain 21841781
esv3639795 CNV loss 21293372

Variation tolerance for PLD2 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.96; 95.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLD2 Gene

Human Gene Mutation Database (HGMD)
PLD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLD2 Gene

Disorders for PLD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLD2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tooth agenesis
  • familial tooth agenesis
- elite association - COSMIC cancer census association via MalaCards
Search PLD2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLD2

Genetic Association Database (GAD)
PLD2
Human Genome Epidemiology (HuGE) Navigator
PLD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLD2
genes like me logo Genes that share disorders with PLD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLD2 Gene

Publications for PLD2 Gene

  1. Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. (PMID: 9582313) Lopez I. … Lambeth J.D. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. (PMID: 11032811) Divecha N. … D'Santos C. (EMBO J. 2000) 3 4 22 64
  3. Characterization of human PLD2 and the analysis of PLD isoform splice variants. (PMID: 9761774) Steed P.M. … Lasala D.J. (FASEB J. 1998) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Epidermal growth factor increases lysophosphatidic acid production in human ovarian cancer cells: roles for phospholipase D2 and receptor transactivation. (PMID: 19864325) Snider A.J. … Meier K.E. (Am. J. Physiol., Cell Physiol. 2010) 3 22 64

Products for PLD2 Gene

Sources for PLD2 Gene

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