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PLD2 Gene

protein-coding   GIFtS: 71
GCID: GC17P004710

Phospholipase D2

  See PLD2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase D21 2     hPLD22 3
Choline Phosphatase 21 2 3     EC 3.1.4.43 8
Phosphatidylcholine-Hydrolyzing Phospholipase D22 3     PLD 23
PLD1C2 3     

External Ids:    HGNC: 90681   Entrez Gene: 53382   Ensembl: ENSG000001292197   OMIM: 6023845   UniProtKB: O149393   

Export aliases for PLD2 gene to outside databases

Previous GC identifers: GC17P005137 GC17P004661 GC17P004917 GC17P004657 GC17P004598


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLD2 Gene:
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline.
The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation
factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization,
cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding
different isoforms have been found for this gene.(provided by RefSeq, Jul 2011)

GeneCards Summary for PLD2 Gene:
PLD2 (phospholipase D2) is a protein-coding gene. Diseases associated with PLD2 include colorectal cancer. GO annotations related to this gene include NAPE-specific phospholipase D activity and phosphatidylinositol binding. An important paralog of this gene is PLD1.

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939
Function: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity)

summary for PLD2 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLD2 gene promoter:
         STAT1   Sp1   AP-1   ATF-2   Lmo2   STAT1beta   STAT1alpha   E47   Hand1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLD2 promoter sequence
   Search Chromatin IP Primers for PLD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

PLD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLD2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004710:  view genomic region     (about GC identifiers)

Start:
4,710,391 bp from pter      End:
4,726,729 bp from pter
Size:
16,339 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939 (See protein sequence)
Recommended Name: Phospholipase D2  
Size: 933 amino acids; 105987 Da
Subunit: Interacts with EGFR (By similarity). Interacts with PIP5K1B
Secondary accessions: O43540 O43579 O43580 Q6PGR0 Q96BY3
Alternative splicing: 3 isoforms:  O14939-1   O14939-2   O14939-3   

Explore the universe of human proteins at neXtProt for PLD2: NX_O14939

Explore proteomics data for PLD2 at MOPED

Post-translational modifications: 

  • Phosphorylated by FGR (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PLD2 (O14939) (see all 20)
     KDWVQLD  DFIDRET  IGSANIN  INSGYSK 


    See PLD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230037.1  NP_002654.3  

    ENSEMBL proteins: 
     ENSP00000263088   ENSP00000459571   ENSP00000459304   ENSP00000458795   ENSP00000461459  
     ENSP00000460250   ENSP00000460477  
    Reactome Protein details: O14939

    PLD2 Human Recombinant Protein Products:

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    Novus Biologicals PLD2 Proteins
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    Cloud-Clone Corp. Proteins for PLD2

     
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    Search eBioscience for ELISAs for PLD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: PLD2
    Phosphatidylcholine-specific phospholipase D

    Selected InterPro protein domains (see all 7):
     IPR016555 PLipase_D_euk
     IPR001683 Phox
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR025202 PLD-like_dom

    Graphical View of Domain Structure for InterPro Entry O14939

    ProtoNet protein and cluster: O14939

    3 Blocks protein domains:
    IPB001683 Phox-like
    IPB001736 Phospholipase D/Transphosphatidylase
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939
    Similarity: Belongs to the phospholipase D family
    Similarity: Contains 1 PH domain
    Similarity: Contains 2 PLD phosphodiesterase domains
    Similarity: Contains 1 PX (phox homology) domain


    Find genes that share domains with PLD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLD2_HUMAN, O14939
    Function: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity)
    Catalytic activity: A phosphatidylcholine + H(2)O = choline + a phosphatidate
    Enzyme regulation: Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation
    factor-1 (ARF-1)

         Genatlas biochemistry entry for PLD2:
    phospholipase D2,106kDa,phosphatidylcholine specific,widely expressed,involved in metabolic regulation,cardiac and
    brain function,senescence regulated secretion,mitogenesis and cytoskeletal changes

         Enzyme Number (IUBMB): EC 3.1.4.41 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004630phospholipase D activity IEA--
    GO:0005515protein binding IPI16407827
    GO:0035091phosphatidylinositol binding IEA--
    GO:0070290NAPE-specific phospholipase D activity IEA--
         
    Find genes that share ontologies with PLD2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PLD2:
     Decreased focal adhesion (FA)   Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pld2):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     normal  tumorigenesis 

    Find genes that share phenotypes with PLD2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PLD2: Pld2tm1Yaka Pld2tm1.1Mjow

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLD2
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    hsa-miR-203 hsa-miR-4291 hsa-miR-214 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidPLD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLD2

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    GenScript: all cDNA clones in your preferred vector: PLD2 (NM_002663)
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12244) for PLD2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLD2_HUMAN, O14939: Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane4
    cytosol3
    nucleus3
    endosome2
    golgi apparatus2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0031526brush border membrane IEA--

    Find genes that share ontologies with PLD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLD2 About   (see all 31)  
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Synthesis of PA0.33
    Phospholipid metabolism0.64
    Synthesis of PG0.00
    Glycerophospholipid metabolism0.62
    choline biosynthesis III0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Fcgamma receptor (FCGR) dependent phagocytosis
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    4GPCR Pathway
    Ras Pathway0.73
    5Translation Translation regulation by Alpha 1 adrenergic receptors
    Translation Translation regulation by Alpha 1 adrenergic receptors0.64


    Find genes that share SuperPaths with PLD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLD2 (see all 8)
        FGF Pathway
    Endothelin-1 Signaling Pathway
    Antioxidant Action of Vitamin-C
    Sperm Motility
    Phospholipase-C Pathway

    1 GeneGo (Thomson Reuters) Pathway for PLD2
        Translation Translation regulation by Alpha-1 adrenergic receptors

    Selected BioSystems Pathways for PLD2 (see all 13)
        EGFR1 Signaling Pathway
    LPA receptor mediated events
    Arf1 pathway
    mTOR signaling pathway
    Arf6 trafficking events

    3 Reactome Pathways for PLD2
        Synthesis of PA
    Synthesis of PG
    Role of phospholipids in phagocytosis


    Selected Kegg Pathways  (Kegg details for PLD2) (see all 8):
        Glycerophospholipid metabolism
    Ether lipid metabolism
    Metabolic pathways
    Ras signaling pathway
    Endocytosis

        Pathway & Disease-focused RT2 Profiler PCR Array including PLD2: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLD2 (O149391, 2, 3 ENSP000002630884) via UniProtKB, MINT, STRING, and/or I2D (see all 168)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-1053996,EBI-401755 MINT-8036231 MINT-8033164 I2D: score=2 STRING: ENSP00000339007
    CFL1P235281, 2, 3, ENSP000003096294EBI-1053996,EBI-352733 MINT-6173922 MINT-6173944 I2D: score=1 STRING: ENSP00000309629
    PTPN1P180312, 3, ENSP000003606834MINT-6796688 MINT-6796717 I2D: score=1 STRING: ENSP00000360683
    ACTBP607093, ENSP000003499604I2D: score=3 STRING: ENSP00000349960
    BIN1O004993, ENSP000003167794I2D: score=3 STRING: ENSP00000316779
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    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002031G-protein coupled receptor internalization IEA--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0006655phosphatidylglycerol biosynthetic process TAS--
    GO:0006898receptor-mediated endocytosis ----

    Find genes that share ontologies with PLD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for PLD2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLD2 (see all 2232)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--
    Ethanolamine1-Amino-2-hydroxyethane (see all 28)141-43-5--
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----

    1 DrugBank Compound for PLD2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CholineBilineurine (see all 7)62-49-7targetproduct of16921342 16878701 16459925 16179605 17627030

    4 IUPHAR Ligands for PLD2 (PLD2)    About this table
    LigandTypeActionAffinityPubmed IDs
    VU0364739
    InhibitorInhibition7.720735042
    PIP2
    ActivatorActivation7.79582313
    ADP-ribosylation factor 1
    ActivatorActivation7.7--
    oleic acid
    ActivatorActivation7.712374567

    Selected Novoseek inferred chemical compound relationships for PLD2 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butanol 79.3 7 15722202 (1), 16236484 (1), 16964281 (1), 15919668 (1) (see all 7)
    phosphatidylcholine 67.6 3 10852916 (1), 11734063 (1), 19855431 (1)
    rottlerin 66.3 2 11058804 (1), 15031293 (1)
    tert-butyl alcohol 64.7 1 15919668 (1)
    choline 50.6 2 11734063 (1)
    pip2 50.5 8 11551222 (5), 10413092 (2), 11706993 (1)
    tyrosine 48.7 32 9837959 (3), 15282299 (3), 15896299 (3), 11459228 (2) (see all 17)
    sphingosine 47.3 5 15081395 (1), 18296444 (1), 11719383 (1), 19519662 (1) (see all 5)
    fenoldopam 43.3 1 15598876 (1)
    gf 109203x 37.9 1 15031293 (1)



    Find genes that share compounds with PLD2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLD2 gene (2 alternative transcripts): 
    NM_001243108.1  NM_002663.4  

    Unigene Cluster for PLD2:

    Phospholipase D2
    Hs.104519  [show with all ESTs]
    Unigene Representative Sequence: NM_002663
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263088(uc002fzd.3 uc002fzc.3) ENST00000572940 ENST00000575246(uc010vsj.2)
    ENST00000574268 ENST00000575316 ENST00000575813 ENST00000574796 ENST00000576329
    ENST00000573258 ENST00000572199 ENST00000576983 ENST00000571273 ENST00000572127
    ENST00000576864 ENST00000575945
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate PLD2:
    hsa-miR-203 hsa-miR-4291 hsa-miR-214 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidPLD2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: PLD2 (NM_002663)
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    eBioscience FlowRNA Probe Sets ( VA1-12244) for PLD2 

    Additional mRNA sequence: 

    AF033850.1 AF035483.1 AF038440.1 AF038441.1 AK304246.1 AK314797.1 AY178289.1 BC015033.1 
    BC056871.1 

    13 DOTS entries:

    DT.113677  DT.75102977  DT.100711879  DT.100785448  DT.120900261  DT.75102978  DT.91647319  DT.99944047 
    DT.99977013  DT.100757001  DT.91741670  DT.97814044  DT.97762903 

    Selected AceView cDNA sequences (see all 155):

    CK826333 AI361359 BX115919 BX283768 AI049997 CN481406 BM666553 AI867089 
    AW337325 BQ614352 BE855751 AL711408 CR600915 AL524142 BU630203 NM_002663 
    BQ575318 BU624336 BX412656 BE887047 BC015033 BM807149 BC056871 BM700601 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLD2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:                                                                          -                                               -                 -           -   
    SP2:                                                                          -                                               -                 -           -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b
    SP1:                                                            
    SP2:                                      -                     
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for PLD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCAAAGGA
    PLD2 Expression
    About this image


    PLD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PLD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104519

    UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including PLD2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PLD2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pld21 , 5 phospholipase D21, 5 87.17(n)1
    90.03(a)1
      11 (42.99 cM)5
    188061  NM_008876.21  NP_032902.11 
     705400645 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    49(a)
    many ↔ many
    3(6855765-6972425)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pld21 phospholipase D2 64(n)
    63.35(a)
      100216200  NM_001142169.1  NP_001135641.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pld21 phospholipase D2 61.35(n)
    62.39(a)
      565743  XM_689557.5  XP_694649.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pld3 phospholipase D 47(a)   42A15   --
    worm
    (Caenorhabditis elegans)
    Secernentea pld-13 phospholipase D 47(a)   II(5084210-5091623)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPO14(YKR031C)4 Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, more   --   11(506395-501344) 853902  NP_012956.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.20782 Transcribed sequence with moderate similarity to protein more 74.28(n)    BQ465002.1 


    ENSEMBL Gene Tree for PLD2 (if available)
    TreeFam Gene Tree for PLD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLD2 gene
    PLD12  
    1 SIMAP similar gene for PLD2 using alignment to 8 protein entries:     PLD2_HUMAN (see all proteins):
    PLD1

    Find genes that share paralogs with PLD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLD2 (see all 619)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365034
    A breast cancer sample4--see VAR_0365032 Q E mis40--------
    rs1880636701,2
    --4695072(+) AGACCA/GGGTGC 2 -- us2k10--------
    rs1168472621,2
    F--4695074(+) ACCGGG/CTGCGG 2 -- us2k11Minor allele frequency- C:0.08EA 120
    rs1809253741,2
    --4695122(+) AGGGCA/GGATCA 2 -- us2k10--------
    rs1471139661,2
    C--4695296(+) AGATCA/GCGCCA 2 -- us2k10--------
    rs1861175161,2
    --4695418(+) GAGGGC/TGGATC 2 -- us2k10--------
    rs1385461641,2
    --4695674(+) GACCAC/TCCTGG 2 -- us2k10--------
    rs1909254781,2
    --4695733(+) TGGGCC/GTGGTG 2 -- us2k10--------
    rs1424887281,2
    --4695987(+) GCCAAG/TCAGCA 2 -- us2k10--------
    rs47907071,2
    C,H--4696212(+) AAACAT/CACACT 2 -- us2k11Minor allele frequency- C:0.00NS 226

    HapMap Linkage Disequilibrium report for PLD2 (4710391 - 4726729 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833346CNV Loss17160897
    nsv833347CNV Loss17160897
    nsv820043CNV Loss19587683

    Human Gene Mutation Database (HGMD): PLD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLD2
    DNA2.0 Custom Variant and Variant Library Synthesis for PLD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602384    OMIM disorders: --

    1 disease for PLD2:    
    About MalaCards
    colorectal cancer


    Find genes that share disorders with PLD2           About GenesLikeMe

    10 Novoseek inferred disease relationships for PLD2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 15.6 1 17640750 (1)
    ewings sarcoma 13.2 4 16964281 (2), 15919668 (2)
    ischemia 0 4 17393174 (2)
    hypertrophy 0 2 16113073 (2)
    breast cancer 0 5 20188462 (2), 15798205 (1), 19478552 (1), 20176813 (1)
    cardiac hypertrophy 0 1 15988127 (1)
    colorectal cancer 0 8 14552589 (5), 16824927 (1)
    tumors 0 8 14552589 (2), 15919668 (1), 18523140 (1), 18006275 (1)
    alzheimers disease 0 2 11080196 (1)
    cancer 0 4 14552589 (1), 19903073 (1), 11741292 (1), 20176813 (1)

    Genetic Association Database (GAD): PLD2
    Human Genome Epidemiology (HuGE) Navigator: PLD2 (8 documents)

    Export disorders for PLD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLD2 gene, integrated from 10 sources (see all 242):
    (articles sorted by number of sources associating them with PLD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. (PubMed id 9582313)1, 2, 3, 9 Lopez I.... Lambeth J.D. (J. Biol. Chem. 1998)
    2. Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. (PubMed id 11032811)1, 2, 9 Divecha N.... D'Santos C. (EMBO J. 2000)
    3. Characterization of human PLD2 and the analysis of PLD isoform splice variants. (PubMed id 9761774)1, 2, 9 Steed P.M.... Lasala D.J. (FASEB J. 1998)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension. (PubMed id 20147969)1, 4 Hong K.W....Oh B. (J Hum Hypertens 2010)
    6. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    8. CCR5 signaling through phospholipase D involves p44/42 MAP-kinases and promotes HIV-1 LTR-directed gene expression. (PubMed id 17627030)1, 7 Paruch S....PAcrianin A. (FASEB J. 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer. (PubMed id 12601529)1, 4 Yamada Y....Nozawa Y. (J. Mol. Med. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5338 HGNC: 9068 AceView: PLD2 Ensembl:ENSG00000129219 euGenes: HUgn5338
    ECgene: PLD2 Kegg: 5338 H-InvDB: PLD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLD2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Phospholipase_D

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLD2 gene:
    Search GeneIP for patents involving PLD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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