Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLD2 Gene

protein-coding   GIFtS: 72
GCID: GC17P004710

Phospholipase D2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase D21 2     hPLD22 3
Choline Phosphatase 21 2 3     EC 3.1.4.43 8
Phosphatidylcholine-Hydrolyzing Phospholipase D22 3     PLD 23
PLD1C2 3     

External Ids:    HGNC: 90681   Entrez Gene: 53382   Ensembl: ENSG000001292197   OMIM: 6023845   UniProtKB: O149393   

Export aliases for PLD2 gene to outside databases

Previous GC identifers: GC17P005137 GC17P004661 GC17P004917 GC17P004657 GC17P004598


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLD2 Gene:
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline.
The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation
factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization,
cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding
different isoforms have been found for this gene.(provided by RefSeq, Jul 2011)

GeneCards Summary for PLD2 Gene: 
PLD2 (phospholipase D2) is a protein-coding gene. Diseases associated with PLD2 include stomach cancer, and lung adenocarcinoma, and among its related super-pathways are Glycerophospholipid biosynthesis and Metabolic pathways. GO annotations related to this gene include NAPE-specific phospholipase D activity and phosphatidylinositol binding. An important paralog of this gene is PLD1.

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939
Function: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity)

summary for PLD2 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLD2 gene promoter:
         STAT1   Sp1   AP-1   ATF-2   Lmo2   STAT1beta   STAT1alpha   E47   Hand1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

PLD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLD2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004710:  view genomic region     (about GC identifiers)

Start:
4,710,391 bp from pter      End:
4,726,729 bp from pter
Size:
16,339 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939 (See protein sequence)
Recommended Name: Phospholipase D2  
Size: 933 amino acids; 105987 Da
Subunit: Interacts with EGFR (By similarity). Interacts with PIP5K1B
Subcellular location: Membrane; Peripheral membrane protein (By similarity)
Secondary accessions: O43540 O43579 O43580 Q6PGR0 Q96BY3
Alternative splicing: 3 isoforms:  O14939-1   O14939-2   O14939-3   

Explore the universe of human proteins at neXtProt for PLD2: NX_O14939

Explore proteomics data for PLD2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by FGR (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14939

  • 4/20 DME Specific Peptides for PLD2 (O14939) (see all 20)
     KDWVQLD  DFIDRET  IGSANIN  INSGYSK 

    PLD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLD2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001230037.1  NP_002654.3  

    ENSEMBL proteins: 
     ENSP00000263088   ENSP00000459571   ENSP00000459304   ENSP00000458795   ENSP00000461459  
     ENSP00000460250   ENSP00000460477  
    Reactome Protein details: O14939
    Human Recombinant Protein Products for PLD2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PLD2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PLD2
    GenScript Custom Purified and Recombinant Proteins Services for PLD2
    Novus Biologicals PLD2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLD2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0031526brush border membrane IEA--

    PLD2 for ontologies           About GeneDecksing



    PLD2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PLD2
    GenScript Custom Superior Antibodies Services for PLD2
    Novus Biologicals PLD2 Antibodies
    Abcam antibodies for PLD2
    Cloud-Clone Corp. Antibodies for PLD2 
    ThermoFisher Antibodies for PLD2
    LSBio Antibodies in human, mouse, rat for PLD2 

    Assay Products for PLD2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PLD2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PLD2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PLD2 
    Cloud-Clone Corp. CLIAs for PLD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: PLD2 
    Phosphatidylcholine-specific phospholipase D

    5/7 InterPro protein domains (see all 7):
     IPR016555 PLipase_D_euk
     IPR001683 Phox
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR025202 PLD-like_dom

    Graphical View of Domain Structure for InterPro Entry O14939

    ProtoNet protein and cluster: O14939

    3 Blocks protein domains:
    IPB001683 Phox-like
    IPB001736 Phospholipase D/Transphosphatidylase
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939
    Similarity: Belongs to the phospholipase D family
    Similarity: Contains 1 PH domain
    Similarity: Contains 2 PLD phosphodiesterase domains
    Similarity: Contains 1 PX (phox homology) domain


    PLD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLD2_HUMAN, O14939
    Function: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity)
    Catalytic activity: A phosphatidylcholine + H(2)O = choline + a phosphatidate
    Enzyme regulation: Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation
    factor-1 (ARF-1)

         Genatlas biochemistry entry for PLD2:
    phospholipase D2,106kDa,phosphatidylcholine specific,widely expressed,involved in metabolic regulation,cardiac and
    brain function,senescence regulated secretion,mitogenesis and cytoskeletal changes

         Enzyme Number (IUBMB): EC 3.1.4.41 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004630phospholipase D activity IEA--
    GO:0005515protein binding IPI16407827
    GO:0005543phospholipid binding ----
    GO:0035091phosphatidylinositol binding IEA--
         
    PLD2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PLD2:
     Decreased focal adhesion (FA)   Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pld2):
     behavior/neurological  homeostasis/metabolism  immune system  nervous system  normal 
     tumorigenesis 

    PLD2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PLD2: Pld2tm1Yaka Pld2tm1.1Mjow

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLD2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLD2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLD2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLD2
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PLD2:
    hsa-miR-203 hsa-miR-4291 hsa-miR-214 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidPLD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLD2
    Sirion Biotech Customized adenovirus for overexpression of PLD2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PLD2 (see all 7)
    OriGene ORF clones in mouse, rat for PLD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLD2 (NM_002663)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLD2
    Sirion Biotech Customized lentivirus for stable overexpression of PLD2 
                         Customized lentivirus expression plasmids for stable overexpression of PLD2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLD2
    Search LifeMap BioReagents cell lines for PLD2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLD2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLD2 About   (see all 32)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3Acyl chain remodelling of PE
    Ether lipid metabolism0.46
    Synthesis of PA0.41
    4choline biosynthesis III
    choline biosynthesis III0.42
    Synthesis of PG0.42
    5Immune System
    Immune System0.56
    Innate Immune System0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PLD2
        Translation Translation regulation by Alpha-1 adrenergic receptors

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLD2 (see all 8)
        FGF Pathway
    Endothelin-1 Signaling Pathway
    Antioxidant Action of Vitamin-C
    Sperm Motility
    Phospholipase-C Pathway

    1 GeneGo (Thomson Reuters) Pathway for PLD2
        Translation Translation regulation by Alpha-1 adrenergic receptors

    5/13 BioSystems Pathways for PLD2 (see all 13)
        EGFR1 Signaling Pathway
    mTOR signaling pathway
    Fc-epsilon receptor I signaling in mast cells
    Arf6 downstream pathway
    ErbB1 downstream signaling

    5/10        Reactome Pathways for PLD2 (see all 10)
        Synthesis of PA
    Metabolism
    Fcgamma receptor (FCGR) dependent phagocytosis
    Phospholipid metabolism
    Synthesis of PG


    5/7         Kegg Pathways  (Kegg details for PLD2) (see all 7):
        Glycerophospholipid metabolism
    Ether lipid metabolism
    Metabolic pathways
    Endocytosis
    Fc gamma R-mediated phagocytosis


    PLD2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/110 Interacting proteins for PLD2 (O149391, 2, 3 ENSP000002630884) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-1053996,EBI-401755 MINT-8036231 MINT-8033164 I2D: score=2 STRING: ENSP00000339007
    CFL1P235282, 3, ENSP000003096294MINT-6173922 MINT-6173944 I2D: score=1 STRING: ENSP00000309629
    PTPN1P180312, 3, ENSP000003606834MINT-6796688 MINT-6796717 I2D: score=1 STRING: ENSP00000360683
    ACTBP607093, ENSP000003499604I2D: score=3 STRING: ENSP00000349960
    BIN1O004993, ENSP000003167794I2D: score=3 STRING: ENSP00000316779
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002031G-protein coupled receptor internalization IEA--
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0006655phosphatidylglycerol biosynthetic process TAS--
    GO:0006898receptor-mediated endocytosis ----

    PLD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLD2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PLD2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    10/2232 HMDB Compounds for PLD2 (see all 2232)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--
    Ethanolamine1-Amino-2-hydroxyethane (see all 28)141-43-5--
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----

    1 DrugBank Compound for PLD2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CholineBilineurine (see all 7)62-49-7targetproduct of16921342 16878701 16459925 16179605 17627030

    4 IUPHAR Ligands for PLD2 (PLD2)    About this table 
    LigandTypeActionAffinityPubmed IDs
    VU0364739
    InhibitorInhibition7.720735042
    PIP2
    ActivatorActivation7.79582313
    ADP-ribosylation factor 1
    ActivatorActivation7.7--
    oleic acid
    ActivatorActivation7.712374567

    10/32 Novoseek inferred chemical compound relationships for PLD2 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butanol 79.3 7 15722202 (1), 16236484 (1), 16964281 (1), 15919668 (1) (see all 7)
    phosphatidylcholine 67.6 3 10852916 (1), 11734063 (1), 19855431 (1)
    rottlerin 66.3 2 11058804 (1), 15031293 (1)
    tert-butyl alcohol 64.7 1 15919668 (1)
    choline 50.6 2 11734063 (1)
    pip2 50.5 8 11551222 (5), 10413092 (2), 11706993 (1)
    tyrosine 48.7 32 9837959 (3), 15282299 (3), 15896299 (3), 11459228 (2) (see all 17)
    sphingosine 47.3 5 15081395 (1), 18296444 (1), 11719383 (1), 19519662 (1) (see all 5)
    fenoldopam 43.3 1 15598876 (1)
    gf 109203x 37.9 1 15031293 (1)

    Search CenterWatch for drugs/clinical trials and news about PLD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLD2 gene (2 alternative transcripts): 
    NM_001243108.1  NM_002663.4  

    Unigene Cluster for PLD2:

    Phospholipase D2
    Hs.104519  [show with all ESTs]
    Unigene Representative Sequence: NM_002663
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263088(uc002fzd.3 uc002fzc.3) ENST00000572940 ENST00000575246(uc010vsj.2)
    ENST00000574268 ENST00000575316 ENST00000575813 ENST00000574796 ENST00000576329
    ENST00000573258 ENST00000572199 ENST00000576983 ENST00000571273 ENST00000572127
    ENST00000576864 ENST00000575945
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLD2
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PLD2:
    hsa-miR-203 hsa-miR-4291 hsa-miR-214 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidPLD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLD2
    Clone
    Products:
         
    OriGene clones in human, mouse for PLD2 (see all 7)
    OriGene ORF clones in mouse, rat for PLD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLD2 (NM_002663)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLD2
    Sirion Biotech Customized lentivirus for stable overexpression of PLD2 
                         Customized lentivirus expression plasmids for stable overexpression of PLD2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PLD2
    OriGene qSTAR qPCR primer pairs in human, mouse for PLD2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLD2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLD2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLD2

    Additional mRNA sequence: 

    AF033850.1 AF035483.1 AF038440.1 AF038441.1 AK304246.1 AK314797.1 AY178289.1 BC015033.1 
    BC056871.1 

    13 DOTS entries:

    DT.113677  DT.75102977  DT.100711879  DT.100785448  DT.120900261  DT.75102978  DT.91647319  DT.99944047 
    DT.99977013  DT.100757001  DT.91741670  DT.97814044  DT.97762903 

    24/155 AceView cDNA sequences (see all 155):

    AW337325 CN481406 AI361359 BQ614352 CR600915 AI867089 BQ575318 BX412656 
    BM807149 BE887047 BU624336 NM_002663 AI049997 BX283768 BE855751 AL711408 
    BC015033 BU630203 BX115919 AL524142 BM700601 BC056871 CK826333 BM666553 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PLD2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:                                                                          -                                               -                 -           -   
    SP2:                                                                          -                                               -                 -           -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b
    SP1:                                                            
    SP2:                                      -                     
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for PLD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLD2 expression in normal human tissues (normalized intensities)      PLD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCAAAGGA
    PLD2 Expression
    About this image


    PLD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See PLD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLD2

    SOURCE GeneReport for Unigene cluster: Hs.104519

    UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including PLD2: 
              mTOR Signaling in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PLD2
    OriGene qSTAR qPCR primer pairs in human, mouse for PLD2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLD2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLD2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PLD2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pld21 , 5 phospholipase D21, 5 87.17(n)1
    90.03(a)1
      11 (42.99 cM)5
    188061  NM_008876.21  NP_032902.11 
     705400645 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    46(a)
    possible ortholog
    AAWZ02040726(1639-6496)
    zebrafish
    (Danio rerio)
    Actinopterygii pld21 phospholipase D2 61.15(n)
    61.56(a)
      565743  XM_689557.4  XP_694649.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pld3 phospholipase D 47(a)   42A15   --
    worm
    (Caenorhabditis elegans)
    Secernentea pld-13 phospholipase D 47(a)   II(5084210-5091623)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPO14(YKR031C)4 Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, more   --   11(506395-501344) 853902  NP_012956.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.20782 Transcribed sequence with moderate similarity to protein more 74.28(n)    BQ465002.1 


    ENSEMBL Gene Tree for PLD2 (if available)
    TreeFam Gene Tree for PLD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLD2 gene
    PLD12  
    1 SIMAP similar gene for PLD2 using alignment to 8 protein entries:     PLD2_HUMAN (see all proteins):
    PLD1

    PLD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/619 SNPs in PLD2 are shown (see all 619)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365034
    A breast cancer sample4--see VAR_0365032 Q E mis40--------
    rs1880636701,2
    --4695072(+) AGACCA/GGGTGC 2 -- us2k10--------
    rs1168472621,2
    F--4695074(+) ACCGGG/CTGCGG 2 -- us2k11Minor allele frequency- C:0.08EA 120
    rs1809253741,2
    --4695122(+) AGGGCA/GGATCA 2 -- us2k10--------
    rs1471139661,2
    C--4695296(+) AGATCA/GCGCCA 2 -- us2k10--------
    rs1861175161,2
    --4695418(+) GAGGGC/TGGATC 2 -- us2k10--------
    rs1385461641,2
    --4695674(+) GACCAC/TCCTGG 2 -- us2k10--------
    rs1909254781,2
    --4695733(+) TGGGCC/GTGGTG 2 -- us2k10--------
    rs1424887281,2
    --4695987(+) GCCAAG/TCAGCA 2 -- us2k10--------
    rs47907071,2
    C,H--4696212(+) AAACAT/CACACT 2 -- us2k11Minor allele frequency- C:0.00NS 226

    HapMap Linkage Disequilibrium report for PLD2 (4710391 - 4726729 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833346CNV Loss17160897
    nsv833347CNV Loss17160897
    nsv820043CNV Loss19587683


    Human Gene Mutation Database (HGMD): PLD2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PLD2
    DNA2.0 Custom Variant and Variant Library Synthesis for PLD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602384    OMIM disorders: --

    17 diseases for PLD2:    About MalaCards
    stomach cancer    lung adenocarcinoma    pertussis    pheochromocytoma
    colorectal cancer    sarcoma    hypoxia    neuroblastoma
    ischemia    alcoholism    endotheliitis    hypertension
    asthma    adenocarcinoma    breast cancer    ovarian cancer
    neuronitis


    PLD2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for PLD2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 15.6 1 17640750 (1)
    ewings sarcoma 13.2 4 16964281 (2), 15919668 (2)
    ischemia 0 4 17393174 (2)
    hypertrophy 0 2 16113073 (2)
    breast cancer 0 5 20188462 (2), 15798205 (1), 19478552 (1), 20176813 (1)
    cardiac hypertrophy 0 1 15988127 (1)
    colorectal cancer 0 8 14552589 (5), 16824927 (1)
    tumors 0 8 14552589 (2), 15919668 (1), 18523140 (1), 18006275 (1)
    alzheimers disease 0 2 11080196 (1)
    cancer 0 4 14552589 (1), 19903073 (1), 11741292 (1), 20176813 (1)

    Genetic Association Database (GAD): PLD2
    Human Genome Epidemiology (HuGE) Navigator: PLD2 (8 documents)

    Export disorders for PLD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLD2 gene, integrated from 9 sources (see all 239):
    (articles sorted by number of sources associating them with PLD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. (PubMed id 9582313)1, 2, 3, 9 Lopez I.... Lambeth J.D. (1998)
    2. Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. (PubMed id 11032811)1, 2, 9 Divecha N.... D'Santos C. (2000)
    3. Characterization of human PLD2 and the analysis of PLD isoform splice variants. (PubMed id 9761774)1, 2, 9 Steed P.M.... Lasala D.J. (1998)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Non-synonymous single-nucleotide polymorphisms associ ated with blood pressure and hypertension. (PubMed id 20147969)1, 4 Hong K.W....Oh B. (2010)
    6. Association of genetic variants with chronic kidney d isease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (2009)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    8. CCR5 signaling through phospholipase D involves p44/42 MAP-kinases and promotes HIV-1 LTR-directed gene expression. (PubMed id 17627030)1, 7 Paruch S....Perianin A. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer. (PubMed id 12601529)1, 4 Yamada Y....Nozawa Y. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5338 HGNC: 9068 AceView: PLD2 Ensembl:ENSG00000129219 euGenes: HUgn5338
    ECgene: PLD2 Kegg: 5338 H-InvDB: PLD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLD2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Phospholipase_D

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLD2 gene:
    Search GeneIP for patents involving PLD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PLD2  
     OriGene qPCR primer pairs and template standards for PLD2   OriGene Protein Over-expression Lysate for PLD2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PLD2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PLD2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PLD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PLD2   OriGene Custom Protein Services for PLD2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLD2
     QIAGEN SeqTarget long-range PCR primers for resequencing PLD2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLD2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLD2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLD2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLD2
     GenScript Custom Purified and Recombinant Proteins Services for PLD2 GenScript cDNA clones with any tag delivered in your preferred vector for PLD2
     GenScript Custom Assay Services for PLD2 GenScript Custom Superior Antibodies Services for PLD2
     GenScript Custom overexpressing Cell Line Services for PLD2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PLD2 promoter
     Search Chromatin IP Primers for PLD2
     RT2 qPCR Primer Assay in human, mouse, rat PLD2
     GNC Network for PLD2
     SABiosciences PCR Arrays including human, mouse, rat PLD2
     Tocris compounds for PLD2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PLD2 antibodies
     PLD2 proteins
     Antibodies for PLD2
     See all of Abcam's Antibodies, Kits and Proteins for PLD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PLD2
     Antibodies for PLD2
     ELISAs for PLD2
     CLIAs for PLD2
     Search LifeMap BioReagents cell lines for PLD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLD2
     SwitchGear 3'UTR luciferase reporter plasmids for PLD2
     SwitchGear Promoter luciferase reporter plasmids for PLD2
     ThermoFisher Antibodies for PLD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLD2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PLD2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLD2
    Customized:
     lentivirus for stable overexpression of PLD2
     lentivirus expression plasmids for stable overexpression of PLD2
     adenovirus for overexpression of PLD2
     LSBio Antibodies in human, mouse, rat for PLD2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PLD2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4