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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLD2 Gene

protein-coding GIFtS: 70
GCID: GC17P004710

phospholipase D2

Explore 17 diseases affiliated with
PLD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase D2¹ ²		HPLD2¹
Choline Phosphatase 2² ³		EC 3.1.4.4³ ⁸
Phosphatidylcholine-Hydrolyzing Phospholipase D2² ³		PLD 2³
PLD1C² ³

External Ids:	HGNC: 9068¹	Entrez Gene: 5338²	Ensembl: ENSG00000129219⁷	OMIM: 602384⁵	UniProtKB: O14939³

Export aliases for PLD2 gene to outside databases

Previous GC identifers: GC17P005137 GC17P004661 GC17P004917 GC17P004657 GC17P004598

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLD2:

The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The

activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1.

This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle

control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms

have been found for this gene.(provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939

Function: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity)

summary for PLD2:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the

hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and

1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily

activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth

factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological

functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane

phospholipids.

Gene Wiki entry for PLD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLD2 gene promoter:
STAT1 Sp1 AP-1 ATF-2 Lmo2 STAT1beta STAT1alpha E47 Hand1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLD2 promoter sequence

Search SABiosciences Chromatin IP Primers for PLD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3

PLD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLD2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P004710: view genomic region (about GC identifiers)

Start:	4,710,391 bp from pter	End:	4,726,729 bp from pter
Size:	16,339 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939 (See protein sequence)

Recommended Name: Phospholipase D2

Size: 933 amino acids; 105987 Da

Subunit: Interacts with EGFR (By similarity). Interacts with PIP5K1B

Subcellular location: Membrane; Peripheral membrane protein (By similarity)

Secondary accessions: O43540 O43579 O43580 Q6PGR0 Q96BY3

Alternative splicing: 3 isoforms: O14939-1 O14939-2 O14939-3

Explore the universe of human proteins at neXtProt for PLD2: NX_O14939

Post-translational modifications:

Phosphorylated by FGR (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14939

4/20 DME Specific Peptides for PLD2 (O14939) (see all 20)

KDWVQLD

DFIDRET

IGSANIN

INSGYSK

PLD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001230037.1 NP_002654.3

ENSEMBL proteins:

ENSP00000263088 ENSP00000459571 ENSP00000459304 ENSP00000458795 ENSP00000461459

ENSP00000460250 ENSP00000460477

Reactome Protein details: O14939
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PLD2

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005794	Golgi apparatus	--	--
GO:0005886	plasma membrane	TAS	9395408
GO:0005901	caveola	--	--

PLD2 for ontologies About GeneDecksing

PLD2 Antibody Products:

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	Uscn ELISAs and CLIAs for PLD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLD2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR016555 PLipase_D_euk

IPR001683 Phox

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

IPR025202 PLD-like_dom

Graphical View of Domain Structure for InterPro Entry O14939

ProtoNet protein and cluster: O14939

3 Blocks protein families:

IPB001683 Phox-like

IPB001736 Phospholipase D/Transphosphatidylase

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939

Similarity: Belongs to the phospholipase D family

Similarity: Contains 1 PH domain

Similarity: Contains 2 PLD phosphodiesterase domains

Similarity: Contains 1 PX (phox homology) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939

Function: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity)

Catalytic activity: A phosphatidylcholine + H(2)O = choline + a phosphatidate

Enzyme regulation: Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation factor-1

(ARF-1)

Genatlas biochemistry entry for PLD2:

phospholipase D2,106kDa,phosphatidylcholine specific,widely expressed,involved in metabolic regulation,cardiac and

brain function,senescence regulated secretion,mitogenesis and cytoskeletal changes

Enzyme Number (IUBMB): EC 3.1.4.4¹ ²

miRNA Products:		OriGene 3'-UTR Clone: PLD2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLD2
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate PLD2:
		hsa-miR-203 hsa-miR-4291 hsa-miR-214 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: PLD2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLD2 (see all 7) OriGene shRNA RFP: PLD2 OriGene siRNA: PLD2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLD2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PLD2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: PLD2 (NM_002663)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PLD2
		Search LifeMap BioReagents cell lines for PLD2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLD2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004630	phospholipase D activity	IEA	--
GO:0005080	protein kinase C binding	--	--
GO:0005515	protein binding	IPI	17276458
GO:0035091	phosphatidylinositol binding	IEA	--

PLD2 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for PLD2:

Decreased focal adhesion (FA)

Decreased influenza A H1N1 (A/

Decreased influenza A/WSN/33 r

Animal Models:
Mouse knock-out Pld2^tm1.1Mjow for PLD2
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pld2):

behavior/neurological

homeostasis/metabolism

immune system

nervous system

PLD2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glycerophospholipid biosynthesis

	Glycerophospholipid biosynthesis	1.00			Glycerophospholipid metabolism	0.54
	Phospholipid metabolism	0.64

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Translation_Translation regulation by Alpha-1 adrenergic receptors

Translation_Translation regulation by Alpha-1 adrenergic receptors

1.00

Translation Translation regulation by Alpha-1 adrenergic receptors

1.00

Immune System

Immune System

1.00

Innate Immune System

0.46

choline biosynthesis III

choline biosynthesis III

1.00

Synthesis of PG

0.45

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PLD2

Translation Translation regulation by Alpha-1 adrenergic receptors

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLD2 (see all 8)

	FGF Pathway
	Endothelin-1 Signaling Pathway
	Antioxidant Action of Vitamin-C
	Sperm Motility
	Phospholipase-C Pathway

1 GeneGo (Thomson Reuters) Pathway for PLD2

Translation Translation regulation by Alpha-1 adrenergic receptors

5/13 BioSystems Pathways for PLD2 (see all 13)

	EGFR1 Signaling Pathway
	ErbB1 downstream signaling
	Arf6 downstream pathway
	LPA receptor mediated events
	Fc-epsilon receptor I signaling in mast cells

5/10 Reactome Pathways for PLD2 (see all 10)

	Synthesis of PA
	Metabolism
	Fcgamma receptor (FCGR) dependent phagocytosis
	Phospholipid metabolism
	Synthesis of PG

5/7 Kegg Pathways (Kegg details for PLD2) (see all 7):

	Glycerophospholipid metabolism
	Ether lipid metabolism
	Metabolic pathways
	Endocytosis
	Fc gamma R-mediated phagocytosis

PLD2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PLD2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/110 Interacting proteins for PLD2 (O14939^{1, 2, 3} ENSP00000263088⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 110)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993¹^,²^,³, ENSP00000339007⁴	EBI-1053996,EBI-401755 MINT-8036231 MINT-8033164 I2D: score=2 STRING: ENSP00000339007
CFL1	P23528²^,³, ENSP00000309629⁴	MINT-6173922 MINT-6173944 I2D: score=1 STRING: ENSP00000309629
PTPN1	P18031²^,³, ENSP00000360683⁴	MINT-6796688 MINT-6796717 I2D: score=1 STRING: ENSP00000360683
ACTB	P60709³, ENSP00000349960⁴	I2D: score=3 STRING: ENSP00000349960
BIN1	O00499³, ENSP00000316779⁴	I2D: score=3 STRING: ENSP00000316779

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	--	--
GO:0002031	G-protein coupled receptor internalization	IEA	--
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006654	phosphatidic acid biosynthetic process	TAS	--
GO:0006655	phosphatidylglycerol biosynthetic process	TAS	--

PLD2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PLD2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLD2 available from Tocris Bioscience About this table

Compound	Action	CAS #
VU 0364739 hydrochloride	Potent and selective PLD2 inhibitor	[1244639-78-8]

10/2232 HMDB Compounds for PLD2 (see all 2232) About this table

Compound	Synonyms	CAS #	PubMed Ids
PC(O-16:0/18:2(9Z,12Z))	1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)	88542-95-4	12486725
PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)	--	12486725
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)	103597-60-0	12486725
PE(P-16:0e/0:0)	2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e)	--	12486725
PE(P-16:0e/18:1(9Z))	2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine	--	12486725
Choline	(2-Hydroxyethyl)trimethyl ammonium (see all 19)	62-49-7	--
Ethanolamine	1-Amino-2-hydroxyethane (see all 28)	141-43-5	--
LPA(0:0/16:0)	Lysophosphatidic acid(16:0) (see all 6)	--	--
LPA(0:0/18:0)	2-octadecanoyl-phosphatidic acid (see all 6)	--	--
LPA(0:0/18:1(9Z))	LPA(18:1) (see all 10)	--	--

1 DrugBank Compound for PLD2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Choline	Bilineurine (see all 7)	62-49-7	target	product of	16921342 16878701 16459925 16179605 17627030

10/32 Novoseek chemical compound relationships for PLD2 gene (see all 32) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
butanol	79.3	7	15722202 (1), 16236484 (1), 16964281 (1), 15919668 (1) (see all 7)
phosphatidylcholine	67.6	3	10852916 (1), 11734063 (1), 19855431 (1)
rottlerin	66.3	2	11058804 (1), 15031293 (1)
tert-butyl alcohol	64.7	1	15919668 (1)
choline	50.6	2	11734063 (1)
pip2	50.5	8	11551222 (5), 10413092 (2), 11706993 (1)
tyrosine	48.7	32	9837959 (3), 15282299 (3), 15896299 (3), 11459228 (2) (see all 17)
sphingosine	47.3	5	15081395 (1), 18296444 (1), 11719383 (1), 19519662 (1) (see all 5)
fenoldopam	43.3	1	15598876 (1)
gf 109203x	37.9	1	15031293 (1)

Search CenterWatch for drugs/clinical trials and news about PLD2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLD2 gene (2 alternative transcripts):

NM_001243108.1 NM_002663.4

Unigene Cluster for PLD2:

Phospholipase D2

Hs.104519 [show with all ESTs]

Unigene Representative Sequence: NM_002663

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263088(uc002fzd.3 uc002fzc.3) ENST00000572940 ENST00000575246(uc010vsj.2)

ENST00000574268 ENST00000575316 ENST00000575813 ENST00000574796 ENST00000576329

ENST00000573258 ENST00000572199 ENST00000576983 ENST00000571273 ENST00000572127

ENST00000576864 ENST00000575945

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate PLD2:
		hsa-miR-203 hsa-miR-4291 hsa-miR-214 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: PLD2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLD2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLD2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLD2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLD2 (NM_002663)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLD2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLD2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLD2

Additional cDNA sequence:

AF033850.1 AF035483.1 AF038440.1 AF038441.1 AK304246.1 AK314797.1 AY178289.1 BC015033.1

BC056871.1

13 DOTS entries:

DT.113677 DT.75102977 DT.100711879 DT.100785448 DT.120900261 DT.75102978 DT.91647319 DT.99944047

DT.99977013 DT.100757001 DT.91741670 DT.97814044 DT.97762903

24/155 AceView cDNA sequences (see all 155):

NM_002663 AW337325 BC056871 AI049997 CK826333 CR600915 BC015033 BE887047

AI361359 BU624336 BQ575318 AL524142 BM807149 BQ614352 BX412656 BX115919

BX283768 AL711408 CN481406 BE855751 BM666553 BM700601 BU630203 AI867089

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PLD2 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	^	16	^	17a	·	17b	^	18	^	19a	·
SP1:																									-																-						-				-
SP2:																									-																-						-				-
SP3:
SP4:
SP5:

ExUns:	19b	^	20	^	21	^	22	^	23a	·	23b	·	23c	^	24	^	25a	·	25b
SP1:
SP2:													-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PLD2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCAAAGGA

About this image

PLD2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PLD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLD2

SOURCE GeneReport for Unigene cluster: Hs.104519

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939

Tissue specificity: Ubiquitous

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mTOR Signaling in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLD2 gene from 5/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	pld2¹	phospholipase D2	61.15(n) 61.56(a)		565743 XM_689557.4 XP_694649.3
fruit fly (Drosophila melanogaster)	Insecta	Pld³	phospholipase D	47(a)		42A15 --
worm (Caenorhabditis elegans)	Secernentea	pld-1³	phospholipase D	47(a)		II(5084210-5091623) --
thale cress (Arabidopsis thaliana)	eudicotyledons	PLDZETA2⁶ PLDZETA1⁶ (see all 12)	phospholipase D P1 (see all 12)	30(a) 29(a) (see all 12)	many ↔ many many ↔ many (see all 12)	3(1635200-1640348) 3(5711082-5719023)
rice (Oryza sativa)	Liliopsida	-- -- (see all 16)	phospholipase D p1, putative, expressed (see all 16)	28(a) 28(a) (see all 16)	many ↔ many many ↔ many (see all 16)	1(11624632-11636050) 5(16991055-17002359)

ENSEMBL Gene Tree for PLD2 (if available)
TreeFam Gene Tree for PLD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PLD2 gene

PLD1²

1 SIMAP similar gene for PLD2 using alignment to 8 protein entries: PLD2_HUMAN (see all proteins):

PLD1

PLD2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188063670^1,2		--	4708448(+)	`AGACCA/GGGTGC`	2	--	us2k¹		0	--	--	--	--
rs116847262^1,2	F,	--	4708450(+)	`ACCGGG/CTGCGG`	2	--	us2k¹		1		EA	120
rs180925374^1,2		--	4708498(+)	`AGGGCA/GGATCA`	2	--	us2k¹		0	--	--	--	--
rs147113966^1,2		--	4708672(+)	`AGATCA/GCGCCA`	2	--	us2k¹		0	--	--	--	--
rs186117516^1,2		--	4708794(+)	`GAGGGC/TGGATC`	2	--	us2k¹		0	--	--	--	--
rs138546164^1,2		--	4709050(+)	`GACCAC/TCCTGG`	2	--	us2k¹		0	--	--	--	--
rs190925478^1,2		--	4709109(+)	`TGGGCC/GTGGTG`	2	--	us2k¹		0	--	--	--	--
rs142488728^1,2		--	4709363(+)	`GCCAAG/TCAGCA`	2	--	us2k¹		0	--	--	--	--
rs4790707^1,2	C,H,	--	4709588(+)	`AAACAT/CACACT`	2	--	us2k¹		1		NS	226
rs182594385^1,2		--	4709593(+)	`CACACA/TGATAT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLD2 (4710391 - 4726729 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PLD2
3 CNVs: 4986 4985 58795
Human Gene Mutation Database (HGMD): PLD2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLD2 for disorders           About GeneDecksing

OMIM gene information: 602384    OMIM disorders: --

17 diseases for PLD2:    About MalaCards

stomach cancer colorectal cancer astrocytoma breast cancer

lung adenocarcinoma pheochromocytoma sarcoma pertussis

seizures ovarian cancer adenocarcinoma hypertension

hypoxia neuroblastoma neuronitis carcinoma

alcoholism

10 Novoseek disease relationships for PLD2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma	15.6	1	17640750 (1)
ewings sarcoma	13.2	4	16964281 (2), 15919668 (2)
ischemia	0	4	17393174 (2)
hypertrophy	0	2	16113073 (2)
breast cancer	0	5	20188462 (2), 15798205 (1), 19478552 (1), 20176813 (1)
cardiac hypertrophy	0	1	15988127 (1)
colorectal cancer	0	8	14552589 (5), 16824927 (1)
tumors	0	8	14552589 (2), 15919668 (1), 18523140 (1), 18006275 (1)
alzheimers disease	0	2	11080196 (1)
cancer	0	4	14552589 (1), 19903073 (1), 11741292 (1), 20176813 (1)

Genetic Association Database (GAD): PLD2
Human Genome Epidemiology (HuGE) Navigator: PLD2 (8 documents)

Export disorders for PLD2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLD2 gene, integrated from 9 sources (see all 233):
(articles sorted by number of sources associating them with PLD2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. (PubMed id 9582313)^{1, 2, 3, 9} Lopez I.... Lambeth J.D. (1998)
Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. (PubMed id 11032811)^{1, 2, 9} Divecha N.... D'Santos C. (2000)
Characterization of human PLD2 and the analysis of PLD isoform splice variants. (PubMed id 9761774)^{1, 2, 9} Steed P.M.... Lasala D.J. (1998)
CCR5 signaling through phospholipase D involves p44/42 MAP-kinases and promotes HIV-1 LTR-directed gene expression. (PubMed id 17627030)^{1, 7} Paruch S....Perianin A. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer. (PubMed id 12601529)^{1, 4} Yamada Y....Nozawa Y. (2003)
Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization. (PubMed id 9858823)^{1, 3} Park S.H....Kim H. (1998)
Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells. (PubMed id 18523140)^{1, 9} Knoepp S.M....Meier K.E. (2008)
Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. (PubMed id 15282299)^{1, 9} Choi W.S....Beaven M.A. (2004)
Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells. (PubMed id 12753082)^{1, 9} Kim J.H....Ryu S.H. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5338	HGNC: 9068	AceView: PLD2	Ensembl:ENSG00000129219	euGenes: HUgn5338
ECgene: PLD2	Kegg: 5338	H-InvDB: PLD2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PLD2	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Phospholipase_D

Intellectual Property for PLD2 gene
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Patent Information for PLD2 gene:
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GeneCards and IP:
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