V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

PLD2 Gene

protein-coding GIFtS: 71

GC17P004657

phospholipase D2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.4.4 ^³
PLD1C ^³
hPLD2 ^³

Descriptions
Choline phosphatase 2 ^², ³
PLD 2 ^³
Phosphatidylcholine-hydrolyzing phospholipase D2 ^³
phospholipase D2 ^²

External Ids
HGNC: 9068¹
Entrez Gene: 5338²
UniProtKB: O14939³
Ensembl: ENSG00000129219⁷

Search outside databases for aliases for PLD2 gene

Previous GC identifers: GC17P005137 GC17P004661 GC17P004917

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PLD2:

Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC

to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence

of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs

have been proposed to function in regulated secretion, cytoskeletal reorganization,

transcriptional regulation, and cell cycle control.[supplied by OMIM]

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939

Function: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By

similarity)

Gene Wiki entry for PLD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PLD2 gene

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3

PLD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P004657: (about GC identifiers)

Start:	4,657,378 bp from pter
End:	4,673,694 bp from pter
Size:	16,317 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939 (See protein sequence)

Recommended Name: Phospholipase D2

Size: 933 amino acids; 105987 Da

Subunit: Interacts with EGFR (By similarity). Interacts with PIP5K1A

Subcellular location: Membrane; Peripheral membrane protein (By similarity)

Secondary accessions: O43540 O43579 O43580 Q96BY3

Alternative splicing: 3 isoforms: O14939-1 O14939-2 O14939-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002654.3

ENSEMBL proteins:

ENSP00000263088

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PLD2
	Recombinant Proteins from Abcam (Phospholipase D2, Phospholipase D1 and Phospholipase D2)
	Human Recombinant Proteins from Abnova (PLD2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	9395408
GO:0031526	brush border membrane	IEA	--

About this table

Antibodies for PLD2:

	Invitrogen Antibodies for PLD2
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PLD2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Phospholipase D2, Phospholipase D1 and Phospholipase D2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PLD2)
	Novus Biologicals Antibodies for PLD2

Assays for PLD2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O14939

ProtoNet protein and cluster: O14939

3 Blocks protein families:

IPB001683 Phox-like

IPB001736 Phospholipase D/Transphosphatidylase

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939

Similarity: Belongs to the phospholipase D family

Similarity: Contains 1 PH domain

Similarity: Contains 2 PLD phosphodiesterase domains

Similarity: Contains 1 PX (phox homology) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PLD2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PLD2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002663

Applied Biosystems Silencer® siRNAs for PLD2

Sigma-Aldrich siRNA for PLD2

Sigma-Aldrich shRNA for PLD2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PLD2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002663
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002663
untagged cDNA clones in CMV expression vector (see all 2): NM_002663

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002663

UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939

Function: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By

similarity)

Catalytic activity: A phosphatidylcholine + H(2)O = choline + a phosphatidate

Enzyme regulation: Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the

ADP-ribosylation factor-1 (ARF-1)

Enzyme Number (IUBMB): EC 3.1.4.4

Genatlas biochemistry entry for PLD2:

phospholipase D2,106kDa,phosphatidylcholine specific,widely expressed,involved in metabolic

regulation,cardiac and brain function,senescence regulated secretion,mitogenesis and cytoskeletal

changes

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004630	phospholipase D activity	TAS	9582313
GO:0005515	protein binding	IPI	17276458
GO:0016787	hydrolase activity	IEA	--
GO:0035091	phosphoinositide binding	IEA	--
GO:0070290	NAPE-specific phospholipase D activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for PLD2 (Your Favorite Gene powered by Ingenuity)

Glycerophospholipid Metabolism
IL-8 Signaling
Fc&gamma
Endothelin-1 Signaling
Phospholipid Degradation

GeneDecks PLD2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PLD2

5/96 Interacting proteins for PLD2 (ENSP00000263088³ O14939^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 96 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993¹	STRING (score=.953) EBI-1053996, EBI-401755
PTPN1	P18031²	STRING (score=.741) MINT-6796688 MINT-6796717
CFL1	P23528²	MINT-6173922 MINT-6173944
ARF1	ENSP00000272102³	STRING (score=.999)
PRKCA	ENSP00000284384³	STRING (score=.997)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002031	G-protein coupled receptor internalization	IEA	--
GO:0006898	receptor-mediated endocytosis	IEA	--
GO:0007010	cytoskeleton organization	TAS	9395408
GO:0007154	cell communication	IEA	--
GO:0007264	small GTPase mediated signal transduction	TAS	9582313

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PLD2

Sigma-Aldrich Small Molecules for PLD2:

Agonist Inhibitor

Browse Tocris compounds for PLD2
10/19 Novoseek chemical compound relationships for PLD2 gene (see all 19 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
butanol	80.87	7	15722202 (1), 16236484 (1), 16964281 (1), 15919668 (1) (see all 7)
tert-butyl alcohol	57.48	1	15919668 (1)
pip2	52.26	8	11551222 (5), 10413092 (2), 11706993 (1)
tyrosine	47.52	31	9837959 (3), 15282299 (3), 15896299 (3), 11459228 (2) (see all 16)
sphingosine	44.88	4	15081395 (1), 18296444 (1), 11719383 (1), 18424723 (1)
oleic acid	33.98	15	12374567 (6), 10413092 (3)
lipid	32.91	6	11032811 (2), 18946083 (1), 17597824 (1), 11706993 (1)
ceramides	31.39	5	11551222 (4), 12829737 (1)
phosphatidylinositol	30.49	1	16179605 (1)
threonine	19.21	4	12014986 (1), 15031293 (1), 16520553 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PLD2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PLD2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002663

Sigma-Aldrich siRNA for PLD2

Sigma-Aldrich shRNA for PLD2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002663

REFSEQ mRNAs for PLD2 gene:

NM_002663.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002663

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002663
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002663
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002663

Additional cDNA sequence:

AB209374.1 AF033850.1 AF035483.1 AF038440.1 AF038441.1 AK304246.1 AK314797.1 AY178289.1

BC015033.1 BC056871.1 CR600915.1

13 DOTS entries:

DT.113677 DT.75102977 DT.100711879 DT.120900261 DT.100785448 DT.75102978 DT.91647319 DT.99944047

DT.99977013 DT.100757001 DT.91741670 DT.97814044 DT.97762903

24/155 AceView cDNA sequences (see all 155 ):

BX283768 AI867089 AI361359 BC015033 BE855751 AL711408 BM807149 BM700601

BQ614352 NM_002663 AI049997 BX115919 AL524142 BX412656 BU624336 BQ575318

BC056871 CR600915 BE887047 BM666553 BU630203 AW337325 CN481406 CK826333

highest scoring ESTs for PLD2:

AF038440 AA302751 AA302752 AA418524 AA418601 AA428742 AA476855 AA632736 AA678646 AA968501

Unigene Cluster for PLD2:

Phospholipase D2

Hs.104519 [show with all ESTs]

Unigene Representative Sequence: AB209374

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PLD2 (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	^	16	^	17a	·	17b	^	18	^	19a	·
SP1:																									-																-						-				-
SP2:																									-																-						-				-
SP3:
SP4:
SP5:

ExUns:	19b	^	20	^	21	^	22	^	23a	·	23b	·	23c	^	24	^	25a	·	25b
SP1:
SP2:													-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PLD2

1 Ensembl transcript including schematic representation:

ENST00000263088

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PLD2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PLD2

¹ / ² / ³

3 probe-sets matching PLD2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41394_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF038440	1.00	1.00	1.00	1
209643_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF033850	0.80	1.00	0.91	1
209643_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGCAAAGGA

SOURCE GeneReport for Unigene cluster: Hs.104519
Expression variation in blood from EXPOLDB for PLD2
UniProtKB/Swiss-Prot: PLD2_HUMAN, O14939
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PLD2 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PLD2¹	--	phospholipase D2	88.78(n) 92.06(a)	479473 XM_536610.2 XP_536610.2
chimpanzee (Pan troglodytes)	PLD2¹	--	phospholipase D2	97.51(n) 97.29(a)	454454 XM_511291.2 XP_511291.2
cow (Bos taurus)	PLD2¹	--	phospholipase D2	90.32(n) 92.28(a)	522159 NM_001075827.1 NP_001069295.1
rat (Rattus norvegicus)	Pld2¹	--	phospholipase D2	87.53(n) 90.46(a)	25097 NM_033299.2 NP_150641.2
mouse (Mus musculus)	Pld2^{1, 5}	11 (39.00 cM)⁵	phospholipase D2^{1, 5}	87.21(n)¹ 90.03(a)¹	18806¹ NM_008876.2¹ NP_032902.1¹ AF052291⁵ AF052292⁵ (see all 15)

About this table Species with no ortholog for PLD2

ENSEMBL Gene Tree for PLD2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PLD2 gene

PLD1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/105 NCBI SNPs in PLD2 are shown (see all 105 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 46)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3764897^1,2	A,C,F,H	4669842(-)	`CTACCC/TGAAGC`	1	G/S	mis¹		12		EA EU WA NA	2436
	rs1052748^1,2	A,C,F,H	4667435(+)	`TCCCAC/TATACC`	1	T/I	mis¹		8		EU EA WA	838
	rs11545163^1,2	C,F,H	4669791(+)	`ATGGGG/ACAGAG`	1	T/A	mis¹		12		EU EA WA	1208
	rs2286672^1,2	C,F,H	4659581(-)	`GAGACG/AGTTGA`	1	C/R	mis¹		13		EA EU WA	2736
	rs2302323^1,2	H	4673026(-)	`GGTGGC/TCCTGG`	1	G/D	mis¹ ese³		5		EA EU WA	1146
--	rs4790707^1,2	C	4656545(+)	`AAACAC/TACACT`	1	--	ng5¹		0	--	--	--	--
	rs1052742^1,2	C	4657429(+)	`CCGTCC/TGCTCT`	1	--	ut5¹		0	--	--	--	--
	rs1132448^1,2	C,F,H	4665742(+)	`GAGGAA/GGGTGT`	1	E/E	syn¹		7		EA NA EU WA	468
	rs1052751^1,2	C,F,H	4669751(+)	`GTGCTG/AATCGA`	1	L/L	syn¹		13		EA EU WA NA	2526
--	rs1132446^1,2	C	4659359(+)	`CACAGA/TTTTGC`	1	R/R	syn¹		4		EU EA WA	412

About this table

HapMap Linkage Disequilibrium images for PLD2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602384

10 Novoseek disease relationships for PLD2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma	18.22	1	17640750 (1)
ewings sarcoma	16.33	4	16964281 (2), 15919668 (2)
tumors	2.83	8	14552589 (2), 15919668 (1), 18523140 (1), 18006275 (1)
cardiac hypertrophy	2.55	1	15988127 (1)
cancer	0.00	2	14552589 (1), 11741292 (1)
hypertrophy	0.00	2	16113073 (2)
breast cancer	0.00	1	15798205 (1)
alzheimers disease	0.00	2	11080196 (1)
ischemia	0.00	4	17393174 (2)
colorectal cancer	0.00	8	14552589 (5), 16824927 (1)

About this table

Human Gene Mutation Database: PLD2
Genetic Association Database: PLD2
Human Genome Epidemiology Navigator: PLD2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/190 PubMed articles for PLD2 gene (see all 190 ):

Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. (PubMed id 9582313)^{1, 2, 3, 4} Lopez I....Lambeth J.D. (1998)
Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. (PubMed id 11032811)^{1, 3, 4} Divecha N.... D'Santos C. (2000)
Characterization of human PLD2 and the analysis of PLD isoform splice variants. (PubMed id 9761774)^{1, 3, 4} Steed P.M.... Lasala D.J. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer. (PubMed id 12601529)^{3, 6} Yamada Y....Nozawa Y. (2003)
Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization. (PubMed id 9858823)^{2, 3} Park S.H....Kim H. (1998)
Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells. (PubMed id 18523140)^{1, 3} Knoepp S.M....Meier K.E. (2008)
Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. (PubMed id 15282299)^{1, 3} Choi W.S....Beaven M.A. (2004)
Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells. (PubMed id 12753082)^{1, 3} Kim J.H....Ryu S.H. (2003)
Inhibition of muscarinic receptor-linked phospholipase D activation by association with tubulin. (PubMed id 15548524)^{1, 3} Chae Y.C....Ryu S.H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5338	HGNC: 9068	AceView: PLD2	Ensembl:ENSG00000129219	euGenes: HUgn5338
ECgene: PLD2	H-InvDB: PLD2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Phospholipase_D

Licensable Technologies for PLD2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PLD2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PLD2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PLD2		Antibodies for PLD2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PLD2		Small molecules for PLD2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PLD2)
	Antibodies (PLD2)
	Chimera RNAi (PLD2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Phospholipase D2, Phospholipase D1 and Phospholipase D2)
	Antibodies (Phospholipase D2, Phospholipase D1 and Phospholipase D2)

Search OriGene for PLD2

Search Tocris compounds for PLD2

	Drugs/Proteins for PLD2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PLD2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PLD2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

PLD2 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for PLD2

Summaries
for PLD2

Genomic Location
for PLD2

Proteins
for PLD2

Protein Domains/
Families
for PLD2

Gene Function
for PLD2

Pathways & Interactions
for PLD2

Drugs & Compounds
for PLD2

Transcripts
for PLD2

Expression
for PLD2

Orthologs
for PLD2

Paralogs
for PLD2

SNPs/Variants
for PLD2

Disorders & Mutations
for PLD2

Medical News
for PLD2

Publications
for PLD2

Search for PLD2

Genome Databases showing PLD2

Other Databases showing PLD2

Specialized Databases showing PLD2

Licensable Technologies
for PLD2

Services
for PLD2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PLD2 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor PLD2

Summariesfor PLD2

Genomic Locationfor PLD2

Proteinsfor PLD2

Protein Domains/Familiesfor PLD2

Gene Functionfor PLD2

Pathways & Interactionsfor PLD2

Drugs & Compoundsfor PLD2

Transcriptsfor PLD2

Expression for PLD2

Orthologsfor PLD2

Paralogsfor PLD2

SNPs/Variantsfor PLD2

Disorders & Mutationsfor PLD2

Medical Newsfor PLD2

Publicationsfor PLD2

Search for PLD2

Genome Databases showing PLD2

Other Databases showing PLD2

Specialized Databases showing PLD2

Licensable Technologiesfor PLD2

Servicesfor PLD2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PLD2

Summaries
for PLD2

Genomic Location
for PLD2

Proteins
for PLD2

Protein Domains/
Families
for PLD2

Gene Function
for PLD2

Pathways & Interactions
for PLD2

Drugs & Compounds
for PLD2

Transcripts
for PLD2

Expression
for PLD2

Orthologs
for PLD2

Paralogs
for PLD2

SNPs/Variants
for PLD2

Disorders & Mutations
for PLD2

Medical News
for PLD2

Publications
for PLD2

Licensable Technologies
for PLD2

Services
for PLD2