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Aliases for PLD1 Gene

Aliases for PLD1 Gene

  • Phospholipase D1 2 3 5
  • Choline Phosphatase 1 2 4
  • EC 4 63
  • Phosphatidylcholine-Hydrolyzing Phospholipase D1 4
  • Phospholipase D1, Phosphatidylcholine-Specific 2
  • PLD 1 4
  • HPLD1 4

External Ids for PLD1 Gene

Previous GeneCards Identifiers for PLD1 Gene

  • GC03M168371
  • GC03M172277
  • GC03M172722
  • GC03M172641
  • GC03M172636
  • GC03M172801
  • GC03M171318
  • GC03M168688

Summaries for PLD1 Gene

Entrez Gene Summary for PLD1 Gene

  • This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]

GeneCards Summary for PLD1 Gene

PLD1 (Phospholipase D1) is a Protein Coding gene. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Arf6 downstream pathway. GO annotations related to this gene include phosphatidylinositol binding and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD2.

UniProtKB/Swiss-Prot for PLD1 Gene

  • Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).

Tocris Summary for PLD1 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLD1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLD1 Gene

Genomics for PLD1 Gene

Regulatory Elements for PLD1 Gene

Enhancers for PLD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLD1 on UCSC Golden Path with GeneCards custom track

Promoters for PLD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLD1 Gene

171,600,405 bp from pter
171,810,950 bp from pter
210,546 bases
Minus strand

Genomic View for PLD1 Gene

Genes around PLD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLD1 Gene

Proteins for PLD1 Gene

  • Protein details for PLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipase D1
    Protein Accession:

    Protein attributes for PLD1 Gene

    1074 amino acids
    Molecular mass:
    124184 Da
    Quaternary structure:
    • Interacts with PIP5K1B.

    Alternative splice isoforms for PLD1 Gene


neXtProt entry for PLD1 Gene

Proteomics data for PLD1 Gene at MOPED

Post-translational modifications for PLD1 Gene

  • Ubiquitination at Lys 189
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLD1 (PLD1)

Domains & Families for PLD1 Gene

Gene Families for PLD1 Gene

Suggested Antigen Peptide Sequences for PLD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Belongs to the phospholipase D family.
  • Contains 1 PH domain.
  • Contains 2 PLD phosphodiesterase domains.
  • Contains 1 PX (phox homology) domain.
  • Belongs to the phospholipase D family.
genes like me logo Genes that share domains with PLD1: view

Function for PLD1 Gene

Molecular function for PLD1 Gene

GENATLAS Biochemistry:
phospholipase D1,phosphatidylcholine specific,membrane associated,activated by ADP-ribosylation factor 1 by protein kinase C alpha,and Rho A,involved in inflammation,metabolic regulation,oncogenesis,neural and cardiac stimulation
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphatidylcholine + H(2)O = choline + a phosphatidate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate.
UniProtKB/Swiss-Prot Function:
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).

Enzyme Numbers (IUBMB) for PLD1 Gene

genes like me logo Genes that share phenotypes with PLD1: view

Animal Models for PLD1 Gene

MGI Knock Outs for PLD1:

Animal Model Products

miRNA for PLD1 Gene

miRTarBase miRNAs that target PLD1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLD1 Gene

Localization for PLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLD1 Gene

Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Late endosome membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for PLD1 Gene COMPARTMENTS Subcellular localization image for PLD1 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
lysosome 5
plasma membrane 5
vacuole 5
cytosol 4
nucleus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome IDA 14718562
GO:0016324 apical plasma membrane IDA 22797597
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PLD1: view

Pathways & Interactions for PLD1 Gene

genes like me logo Genes that share pathways with PLD1: view

SIGNOR curated interactions for PLD1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006654 phosphatidic acid biosynthetic process IEA,TAS --
GO:0006655 phosphatidylglycerol biosynthetic process TAS --
GO:0007264 small GTPase mediated signal transduction TAS 8530346
GO:0016042 lipid catabolic process IEA --
GO:0030334 regulation of cell migration IEA --
genes like me logo Genes that share ontologies with PLD1: view

Drugs & Compounds for PLD1 Gene

(20) Drugs for PLD1 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Target, product of 139
Miltefosine Approved Pharma Enzyme, substrate PI3K/Akt inhibitor 33
Ethanolamine Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
LAX-101 Investigational Pharma Target 0

(36) Additional Compounds for PLD1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide hydroxide inner salt
  • (R)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]-3,5,9-Trioxa-4-phosphapentacosan-1-aminium 4-oxide inner salt
  • 1,2-Bis(hexadecanoyl)-sn-glycero-3-phosphocholine
  • 1,2-Bis(palmitoyl)-sn-glycero-3-phosphocholine
  • 1,2-Dihexadecanoyl-sn-glycerol-3-phosphorylcholine
63-89-8, 68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)

(5) Tocris Compounds for PLD1 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLD1: view

Transcripts for PLD1 Gene

Unigene Clusters for PLD1 Gene

Phospholipase D1, phosphatidylcholine-specific:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: - - -
SP2: - - - -

ExUns: 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b

Relevant External Links for PLD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLD1 Gene

mRNA expression in normal human tissues for PLD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLD1 Gene

This gene is overexpressed in Cervix (26.1) and Adrenal (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLD1 Gene

SOURCE GeneReport for Unigene cluster for PLD1 Gene Hs.382865

mRNA Expression by UniProt/SwissProt for PLD1 Gene

Tissue specificity: Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine.
genes like me logo Genes that share expression patterns with PLD1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PLD1 Gene

Orthologs for PLD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLD1 35
  • 91 (n)
  • 92.16 (a)
  • 92 (a)
(Canis familiaris)
Mammalia PLD1 35
  • 87.8 (n)
  • 89.11 (a)
PLD1 36
  • 90 (a)
(Mus musculus)
Mammalia Pld1 35
  • 84.68 (n)
  • 91.31 (a)
Pld1 16
Pld1 36
  • 91 (a)
(Pan troglodytes)
Mammalia PLD1 35
  • 99.41 (n)
  • 99.72 (a)
PLD1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pld1 35
  • 84.46 (n)
  • 90.53 (a)
(Monodelphis domestica)
Mammalia PLD1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 73 (a)
-- 36
  • 79 (a)
-- 36
  • 81 (a)
-- 36
  • 91 (a)
(Gallus gallus)
Aves PLD1 35
  • 74.54 (n)
  • 81.03 (a)
PLD1 36
  • 80 (a)
(Anolis carolinensis)
Reptilia PLD1 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pld1 35
  • 72.92 (n)
  • 78.72 (a)
(Danio rerio)
Actinopterygii pld1a 35
  • 67.07 (n)
  • 71.7 (a)
pld1a 36
  • 69 (a)
pld1b 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pld 37
  • 46 (a)
Pld 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea pld-1 37
  • 47 (a)
pld-1 35
  • 53.62 (n)
  • 47.7 (a)
pld-1 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPO14 36
  • 19 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PLDP1 35
  • 50.31 (n)
  • 41.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for PLD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLD1 Gene

Gene Tree for PLD1 (if available)
Gene Tree for PLD1 (if available)

Paralogs for PLD1 Gene

Paralogs for PLD1 Gene

(1) SIMAP similar genes for PLD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PLD1: view

Variants for PLD1 Gene

Sequence variations from dbSNP and Humsavar for PLD1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2290480 - 171,686,688(+) ACCAG(A/C)ATGAG intron-variant, nc-transcript-variant, reference, missense
rs2287579 - 171,644,995(+) TATCA(C/T)GACAT reference, missense
rs9819927 - 171,737,907(+) CTTGG(C/G)ATCGC nc-transcript-variant, reference, missense
rs9827333 - 171,603,233(+) TAATA(C/T)GGGCT reference, missense
rs705025 -- 171,630,162(+) aaatt(G/T)acaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLD1 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv877983 CNV Loss 21882294
esv268047 CNV Insertion 20981092
esv273728 CNV Insertion 20981092
esv2550334 CNV Deletion 19546169
nsv822343 CNV Loss 20364138
esv2424106 CNV Deletion 19546169
nsv877985 CNV Gain 21882294
esv2726206 CNV Deletion 23290073

Variation tolerance for PLD1 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLD1 Gene

Disorders for PLD1 Gene

Relevant External Links for PLD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLD1 Gene

Publications for PLD1 Gene

  1. Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. (PMID: 8530346) Hammond S.M. … Frohman M.A. (J. Biol. Chem. 1995) 2 3 4 67
  2. Platelet derived growth factor increases phospholipase D1 but not phospholipase D2 expression via NFkappaB signaling pathway and enhances invasion of breast cancer cells. (PMID: 20188462) Kang D.W. … Min d.o. .S. (Cancer Lett. 2010) 3 23
  3. Dependence of phospholipase D1 multi-monoubiquitination on its enzymatic activity and palmitoylation. (PMID: 20189990) Yin H. … Zheng X.L. (J. Biol. Chem. 2010) 3 23
  4. Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake. (PMID: 20231899) Kim J.H. … Ryu S.H. (PLoS ONE 2010) 3 23
  5. Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/beta-catenin/TCF signaling axis. (PMID: 20442281) Kang D.W. … Min d.o. .S. (Cancer Res. 2010) 3 23

Products for PLD1 Gene

Sources for PLD1 Gene