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Aliases for PLCZ1 Gene

Aliases for PLCZ1 Gene

  • Phospholipase C, Zeta 1 2 3
  • Phosphoinositide Phospholipase C-Zeta-1 3 4
  • EC 3.1.4.11 4 64
  • PLC-Zeta-1 3 4
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Zeta-1 3
  • Testis-Development Related NYD-SP27 3
  • Testis-Development Protein NYD-SP27 4
  • PI-Phospholipase C Zeta 1 3
  • Phospholipase C-Zeta-1 4
  • NYD-SP27 3
  • PLCzeta 3

External Ids for PLCZ1 Gene

Summaries for PLCZ1 Gene

Entrez Gene Summary for PLCZ1 Gene

  • The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for PLCZ1 Gene

PLCZ1 (Phospholipase C, Zeta 1) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include calcium ion binding and phosphatidylinositol phospholipase C activity. An important paralog of this gene is PLCH1.

UniProtKB/Swiss-Prot for PLCZ1 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Tocris Summary for PLCZ1 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCZ1 Gene

Genomics for PLCZ1 Gene

Genomic Location for PLCZ1 Gene

Start:
18,683,169 bp from pter
End:
18,738,086 bp from pter
Size:
54,918 bases
Orientation:
Minus strand

Genomic View for PLCZ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLCZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCZ1 Gene

Regulatory Elements for PLCZ1 Gene

Proteins for PLCZ1 Gene

  • Protein details for PLCZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YW0-PLCZ1_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
    Protein Accession:
    Q86YW0
    Secondary Accessions:
    • Q08AQ7
    • Q96J70

    Protein attributes for PLCZ1 Gene

    Size:
    608 amino acids
    Molecular mass:
    70411 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.

    Alternative splice isoforms for PLCZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCZ1 Gene

Proteomics data for PLCZ1 Gene at MOPED

Post-translational modifications for PLCZ1 Gene

No Post-translational modifications

Domains for PLCZ1 Gene

Gene Families for PLCZ1 Gene

HGNC:
  • EFHAND :EF-hand domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

PLCZ1_HUMAN
Domain:
  • The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.:
    • Q86YW0
  • The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.:
    • Q86YW0
  • Contains 1 C2 domain.:
    • Q86YW0
  • Contains 1 EF-hand domain.:
    • Q86YW0
  • Contains 1 PI-PLC X-box domain.:
    • Q86YW0
  • Contains 1 PI-PLC Y-box domain.:
    • Q86YW0
genes like me logo Genes that share domains with PLCZ1: view

Function for PLCZ1 Gene

Molecular function for PLCZ1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Enzyme Numbers (IUBMB) for PLCZ1 Gene

Gene Ontology (GO) - Molecular Function for PLCZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004629 phospholipase C activity --
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PLCZ1: view
genes like me logo Genes that share phenotypes with PLCZ1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLCZ1 Gene

Localization for PLCZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCZ1 Gene

Nucleus. Cytoplasm, perinuclear region. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250 UniProtKB:Q8K4D7}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCZ1 Gene COMPARTMENTS Subcellular localization image for PLCZ1 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PLCZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PLCZ1: view

Pathways for PLCZ1 Gene

genes like me logo Genes that share pathways with PLCZ1: view

Interacting Proteins for PLCZ1 Gene

Gene Ontology (GO) - Biological Process for PLCZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006816 calcium ion transport IEA --
GO:0007165 signal transduction --
GO:0007275 multicellular organismal development IEA --
GO:0007343 egg activation IEA --
genes like me logo Genes that share ontologies with PLCZ1: view

Compounds for PLCZ1 Gene

(5) Tocris Compounds for PLCZ1 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
FIPI Phospholipase D inhibitor [939055-18-2]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]

(1223) HMDB Compounds for PLCZ1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
genes like me logo Genes that share compounds with PLCZ1: view

Transcripts for PLCZ1 Gene

Unigene Clusters for PLCZ1 Gene

Phospholipase C, zeta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCZ1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - - - - - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: - - -
SP9: - -
SP10: - -
SP11:
SP12:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PLCZ1 Gene

GeneLoc Exon Structure for
PLCZ1
ECgene alternative splicing isoforms for
PLCZ1

Expression for PLCZ1 Gene

mRNA expression in normal human tissues for PLCZ1 Gene

mRNA differential expression in normal tissues according to GTEx for PLCZ1 Gene

This gene is overexpressed in Testis (50.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLCZ1 Gene

SOURCE GeneReport for Unigene cluster for PLCZ1 Gene Hs.97542

mRNA Expression by UniProt/SwissProt for PLCZ1 Gene

Q86YW0-PLCZ1_HUMAN
Tissue specificity: Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis.
genes like me logo Genes that share expressions with PLCZ1: view

Orthologs for PLCZ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLCZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCZ1 36
  • 99.51 (n)
  • 99.51 (a)
PLCZ1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLCZ1 36
  • 85.46 (n)
  • 78.44 (a)
PLCZ1 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCZ1 36
  • 87.88 (n)
  • 81.98 (a)
PLCZ1 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcz1 36
  • 78.68 (n)
  • 75.7 (a)
Plcz1 16
Plcz1 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLCZ1 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcz1 36
  • 78.13 (n)
  • 75.21 (a)
chicken
(Gallus gallus)
Aves PLCZ1 36
  • 67.83 (n)
  • 62.75 (a)
PLCZ1 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCZ1 37
  • 53 (a)
OneToOne
Species with no ortholog for PLCZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLCZ1 Gene

ENSEMBL:
Gene Tree for PLCZ1 (if available)
TreeFam:
Gene Tree for PLCZ1 (if available)

Paralogs for PLCZ1 Gene

Paralogs for PLCZ1 Gene

genes like me logo Genes that share paralogs with PLCZ1: view

Variants for PLCZ1 Gene

Sequence variations from dbSNP and Humsavar for PLCZ1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs901528 -- 18,703,890(+) GAGGG(A/C)AATAC intron-variant
rs1021266 -- 18,723,001(+) ATAGG(A/G)TACAT intron-variant
rs1021267 -- 18,723,067(+) GATAC(A/G)TGGAA intron-variant
rs1027032 -- 18,728,720(+) TTTTC(A/G)AGATA intron-variant
rs1386397 -- 18,686,506(+) TTTTA(A/G)GACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCZ1 Gene

Variant ID Type Subtype PubMed ID
nsv898837 CNV Gain 21882294

Relevant External Links for PLCZ1 Gene

HapMap Linkage Disequilibrium report
PLCZ1
Human Gene Mutation Database (HGMD)
PLCZ1

Disorders for PLCZ1 Gene

(1) University of Copenhagen DISEASES for PLCZ1 Gene

Relevant External Links for PLCZ1

Genetic Association Database (GAD)
PLCZ1
Human Genome Epidemiology (HuGE) Navigator
PLCZ1
genes like me logo Genes that share disorders with PLCZ1: view

No data available for UniProtKB/Swiss-Prot for PLCZ1 Gene

Publications for PLCZ1 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  2. Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C. (PMID: 14697805) Zhu H. … Chang Chan H. (Lancet 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. NYD-SP27, a novel intrinsic decapacitation factor in sperm. (PMID: 19252507) Bi Y. … Sha J.H. (Asian J. Androl. 2009) 3 23
  5. Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes. (PMID: 12416999) Cox L.J. … Lai F.A. (Reproduction 2002) 3 4

Products for PLCZ1 Gene

Sources for PLCZ1 Gene

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