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Aliases for PLCZ1 Gene

Aliases for PLCZ1 Gene

  • Phospholipase C Zeta 1 2 3 5
  • Phosphoinositide Phospholipase C-Zeta-1 3 4
  • Phospholipase C, Zeta 1 2 3
  • EC 3.1.4.11 4 63
  • PLC-Zeta-1 3 4
  • Testis-Development Related NYD-SP27 3
  • Testis-Development Protein NYD-SP27 4
  • Testicular Tissue Protein Li 145 3
  • PI-Phospholipase C Zeta 1 3
  • Phospholipase C-Zeta-1 4
  • NYD-SP27 3
  • PLCzeta 3

External Ids for PLCZ1 Gene

Previous GeneCards Identifiers for PLCZ1 Gene

  • GC12M018980
  • GC12M018736
  • GC12M018727

Summaries for PLCZ1 Gene

Entrez Gene Summary for PLCZ1 Gene

  • The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for PLCZ1 Gene

PLCZ1 (Phospholipase C Zeta 1) is a Protein Coding gene. Diseases associated with PLCZ1 include male reproductive system disease and cystic fibrosis. Among its related pathways are Calcium signaling pathway and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCB3.

UniProtKB/Swiss-Prot for PLCZ1 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Tocris Summary for PLCZ1 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCZ1 Gene

Genomics for PLCZ1 Gene

Regulatory Elements for PLCZ1 Gene

Enhancers for PLCZ1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLCZ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCZ1 Gene

Chromosome:
12
Start:
18,641,990 bp from pter
End:
18,738,059 bp from pter
Size:
96,070 bases
Orientation:
Minus strand

Genomic View for PLCZ1 Gene

Genes around PLCZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCZ1 Gene

Proteins for PLCZ1 Gene

  • Protein details for PLCZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YW0-PLCZ1_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
    Protein Accession:
    Q86YW0
    Secondary Accessions:
    • Q08AQ7
    • Q96J70

    Protein attributes for PLCZ1 Gene

    Size:
    608 amino acids
    Molecular mass:
    70411 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.

    Alternative splice isoforms for PLCZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCZ1 Gene

Proteomics data for PLCZ1 Gene at MOPED

Post-translational modifications for PLCZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PLCZ1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YW0

UniProtKB/Swiss-Prot:

PLCZ1_HUMAN :
  • The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.
Domain:
  • The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.
  • The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.
  • Contains 1 C2 domain.
  • Contains 1 EF-hand domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCZ1: view

Function for PLCZ1 Gene

Molecular function for PLCZ1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Enzyme Numbers (IUBMB) for PLCZ1 Gene

Gene Ontology (GO) - Molecular Function for PLCZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS --
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCZ1: view
genes like me logo Genes that share phenotypes with PLCZ1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCZ1

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLCZ1 Gene

Localization for PLCZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCZ1 Gene

Nucleus. Cytoplasm, perinuclear region. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250 UniProtKB:Q8K4D7}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCZ1 Gene COMPARTMENTS Subcellular localization image for PLCZ1 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for PLCZ1 Gene

Pathways & Interactions for PLCZ1 Gene

genes like me logo Genes that share pathways with PLCZ1: view

Interacting Proteins for PLCZ1 Gene

Gene Ontology (GO) - Biological Process for PLCZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0007343 egg activation IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PLCZ1: view

No data available for SIGNOR curated interactions for PLCZ1 Gene

Drugs & Compounds for PLCZ1 Gene

(2) Drugs for PLCZ1 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
D609 Pharma PC-PLC inhibitor, Selective PC-PLC inhibitor 0

(389) Additional Compounds for PLCZ1 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
Inositol 1,4,5-trisphosphate
  • 1D-Myo-Inositol 1,4,5-trisphosphate
  • D-Myo-Inositol 1,4,5-trisphosphate
  • Inositol 1,4,5-trisphosphate
88269-39-0

(5) Tocris Compounds for PLCZ1 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
RHC 80267 Diacylglycerol lipase inhibitor 83654-05-1
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCZ1: view

Transcripts for PLCZ1 Gene

Unigene Clusters for PLCZ1 Gene

Phospholipase C, zeta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCZ1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - - - - - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: - - -
SP9: - -
SP10: - -
SP11:
SP12:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PLCZ1 Gene

GeneLoc Exon Structure for
PLCZ1
ECgene alternative splicing isoforms for
PLCZ1

Expression for PLCZ1 Gene

mRNA expression in normal human tissues for PLCZ1 Gene

mRNA differential expression in normal tissues according to GTEx for PLCZ1 Gene

This gene is overexpressed in Testis (x50.4).

Protein differential expression in normal tissues from HIPED for PLCZ1 Gene

This gene is overexpressed in Pancreatic juice (63.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLCZ1 Gene



SOURCE GeneReport for Unigene cluster for PLCZ1 Gene Hs.97542

mRNA Expression by UniProt/SwissProt for PLCZ1 Gene

Q86YW0-PLCZ1_HUMAN
Tissue specificity: Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis.
genes like me logo Genes that share expression patterns with PLCZ1: view

Protein tissue co-expression partners for PLCZ1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PLCZ1 Gene

Orthologs for PLCZ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLCZ1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLCZ1 35
  • 85.46 (n)
  • 78.44 (a)
PLCZ1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCZ1 35
  • 87.88 (n)
  • 81.98 (a)
PLCZ1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcz1 35
  • 78.68 (n)
  • 75.7 (a)
Plcz1 16
Plcz1 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLCZ1 35
  • 99.51 (n)
  • 99.51 (a)
PLCZ1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcz1 35
  • 78.13 (n)
  • 75.21 (a)
oppossum
(Monodelphis domestica)
Mammalia PLCZ1 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLCZ1 35
  • 67.83 (n)
  • 62.75 (a)
PLCZ1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCZ1 36
  • 53 (a)
OneToOne
Species with no ortholog for PLCZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLCZ1 Gene

ENSEMBL:
Gene Tree for PLCZ1 (if available)
TreeFam:
Gene Tree for PLCZ1 (if available)

Paralogs for PLCZ1 Gene

Paralogs for PLCZ1 Gene

genes like me logo Genes that share paralogs with PLCZ1: view

Variants for PLCZ1 Gene

Sequence variations from dbSNP and Humsavar for PLCZ1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_050542 -
rs2035623 -- 18,711,603(+) GGGGA(C/T)TGAGA intron-variant
rs2035624 -- 18,711,619(+) agaag(A/T)aggtt intron-variant
rs7133505 -- 18,700,369(+) CCAAG(G/T)TTTGT intron-variant
rs7134412 -- 18,734,414(+) ggcgc(A/C)atctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCZ1 Gene

Variant ID Type Subtype PubMed ID
nsv898837 CNV Gain 21882294

Variation tolerance for PLCZ1 Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLCZ1 Gene

HapMap Linkage Disequilibrium report
PLCZ1
Human Gene Mutation Database (HGMD)
PLCZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCZ1 Gene

Disorders for PLCZ1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLCZ1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
male reproductive system disease
  • genital diseases, male
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
reproductive system disease
  • genital system disease
- elite association - COSMIC cancer census association via MalaCards
Search PLCZ1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLCZ1

Genetic Association Database (GAD)
PLCZ1
Human Genome Epidemiology (HuGE) Navigator
PLCZ1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLCZ1
genes like me logo Genes that share disorders with PLCZ1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLCZ1 Gene

Publications for PLCZ1 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. NYD-SP27, a novel intrinsic decapacitation factor in sperm. (PMID: 19252507) Bi Y. … Sha J.H. (Asian J. Androl. 2009) 3 23
  3. PLCIP or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis. (PMID: 25722320) Kashir J. … Lai F.A. (Mol. Hum. Reprod. 2015) 3
  4. Novel signalling mechanism and clinical applications of sperm-specific PLCIP. (PMID: 26009178) Nomikos M. (Biochem. Soc. Trans. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PLCZ1 Gene

Sources for PLCZ1 Gene

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