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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLCZ1 Gene

protein-coding   GIFtS: 62
GCID: GC12M018736

Phospholipase C, Zeta 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase C, Zeta 11 2     PLCzeta2
Phosphoinositide Phospholipase C-Zeta-12 3     PI-Phospholipase C Zeta 12
PLC-zeta-12 3     Testis-Development Related NYD-SP272
EC 3.1.4.113 8     Phospholipase C-Zeta-13
1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Zeta-12     Testis-Development Protein NYD-SP273
NYD-SP272     

External Ids:    HGNC: 192181   Entrez Gene: 898692   Ensembl: ENSG000001391517   OMIM: 6080755   UniProtKB: Q86YW03   

Export aliases for PLCZ1 gene to outside databases

Previous GC identifers: GC12M018980 GC12M018727 GC12M018604


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLCZ1 Gene:
The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in
this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol
4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This
protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during
fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for PLCZ1 Gene: 
PLCZ1 (phospholipase C, zeta 1) is a protein-coding gene. Diseases associated with PLCZ1 include male infertility, and infertility, and among its related super-pathways are D-myo-inositol (1,4,5)-trisphosphate biosynthesis and Phosphatidylinositol signaling system. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and calcium ion binding. An important paralog of this gene is PLCD4.

UniProtKB/Swiss-Prot: PLCZ1_HUMAN, Q86YW0
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
(IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes
PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M
phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst
stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the
sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on
phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking
and function

summary for PLCZ1 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLCZ1 gene promoter:
         AML1a   Nkx2-2   Cdc5   NF-AT   NF-AT2   FOXJ2 (long isoform)   FOXJ2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCZ1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLCZ1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p13.31

PLCZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCZ1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M018736:  view genomic region     (about GC identifiers)

Start:
18,836,103 bp from pter      End:
18,890,991 bp from pter
Size:
54,889 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLCZ1_HUMAN, Q86YW0 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1  
Size: 608 amino acids; 70411 Da
Cofactor: Calcium (By similarity)
Subunit: Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Exhibits
alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm
upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis
and mitosis (By similarity)
Secondary accessions: Q08AQ7 Q96J70
Alternative splicing: 3 isoforms:  Q86YW0-1   Q86YW0-2   Q86YW0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLCZ1: NX_Q86YW0

Explore proteomics data for PLCZ1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86YW0

  • 4/15 DME Specific Peptides for PLCZ1 (Q86YW0) (see all 15)
     LSDLVIY  WNETFTF  VALNFQT  KGCRCLE 

    PLCZ1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLCZ1 Protein Expression
    REFSEQ proteins: NP_149114.2  
    ENSEMBL proteins: 
     ENSP00000438679   ENSP00000326397   ENSP00000438826   ENSP00000445287   ENSP00000445880  
     ENSP00000443320   ENSP00000266505   ENSP00000445026   ENSP00000445889   ENSP00000443762  
     ENSP00000438629   ENSP00000444611   ENSP00000440781   ENSP00000444383   ENSP00000402358  
     ENSP00000400504   ENSP00000443349  
    Reactome Protein details: Q86YW0
    Human Recombinant Protein Products for PLCZ1: 
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    OriGene Custom MassSpec 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0048471perinuclear region of cytoplasm IEA--

    PLCZ1 for ontologies           About GeneDecksing



    PLCZ1 Antibody Products: 
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    Novus Biologicals PLCZ1 Antibody
    Abcam antibodies for PLCZ1
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    LSBio Antibodies in human, mouse, rat for PLCZ1 

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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: PLCζ1 
    Phosphoinositide-specific phospholipase C

    5/10 InterPro protein domains (see all 10):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR001192 Pinositol_PLipase_C
     IPR018029 C2_membr_targeting

    Graphical View of Domain Structure for InterPro Entry Q86YW0

    ProtoNet protein and cluster: Q86YW0

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C


    UniProtKB/Swiss-Prot: PLCZ1_HUMAN, Q86YW0
    Domain: The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of
    PLCZ1 enzyme activity (By similarity)
    Domain: The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play
    an important regulatory role during fertilization (By similarity)
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain


    PLCZ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCZ1_HUMAN, Q86YW0
    Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
    (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes
    PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M
    phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst
    stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the
    sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on
    phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking
    and function
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
    + diacylglycerol

         Enzyme Number (IUBMB): EC 3.1.4.111 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IEA--
    GO:0004629phospholipase C activity ----
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    PLCZ1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PLCZ1:
     Decreased Salmonella enterica   Decreased Salmonella-containin  Lamellipodia and high actin ra 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLCZ1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLCZ1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLCZ1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLCZ1 

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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCZ1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLCZ1 About   (see all 29)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Anandamide biosynthesis and metabolism
    D-myo-inositol-5-phosphate metabolism0.50
    Anandamide biosynthesis and metabolism0.34
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.50
    phospholipases0.34
    2Inositol phosphate metabolism
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Cellular Effects of Sildenafil0.46
    Melatonin Signaling0.72
    Sperm Motility0.37
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PLCZ1
        Anandamide biosynthesis and metabolism

    5/35 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLCZ1 (see all 35)
        Antioxidant Action of Vitamin-C
    Aldosterone Signaling in Epithelial Cells
    UVA-Induced MAPK Signaling
    PACAP Signaling
    P2Y Receptor Signaling

    1 GeneGo (Thomson Reuters) Pathway for PLCZ1
        Anandamide biosynthesis and metabolism

    4 BioSystems Pathways for PLCZ1
        D-myo-inositol-5-phosphate metabolism
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis
    phospholipases
    superpathway of inositol phosphate compounds

    3        Reactome Pathways for PLCZ1
        Metabolism
    Inositol phosphate metabolism
    Synthesis of IP3 and IP4 in the cytosol

    1 PharmGKB Pathway for PLCZ1
        Proton Pump Inhibitor Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for PLCZ1):
        Inositol phosphate metabolism
    Metabolic pathways
    Calcium signaling pathway
    Phosphatidylinositol signaling system
    Oocyte meiosis


    PLCZ1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLCZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for PLCZ1 (ENSP000002665054) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITPR1ENSP000004059344STRING: ENSP00000405934
    ITPR3ENSP000003634354STRING: ENSP00000363435
    PIK3C2GENSP000004048454STRING: ENSP00000404845
    PIK3C3ENSP000002620394STRING: ENSP00000262039
    PLCB1ENSP000003381854STRING: ENSP00000338185
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006816calcium ion transport IEA--
    GO:0007165signal transduction ----
    GO:0007275multicellular organismal development IEA--
    GO:0007343egg activation IEA--

    PLCZ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PLCZ1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PLCZ1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    10/1223 HMDB Compounds for PLCZ1 (see all 1223)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----

    Search CenterWatch for drugs/clinical trials and news about PLCZ1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLCZ1 gene: 
    NM_033123.3  

    Unigene Cluster for PLCZ1:

    Phospholipase C, zeta 1
    Hs.97542  [show with all ESTs]
    Unigene Representative Sequence: NR_073075
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000536023 ENST00000318197(uc001rdv.4) ENST00000534932 ENST00000543219
    ENST00000538330(uc001rdu.1) ENST00000540270 ENST00000266505 ENST00000539875
    ENST00000540421 ENST00000542762 ENST00000540515 ENST00000543242 ENST00000539072
    ENST00000539207 ENST00000545129 ENST00000535429 ENST00000541966 ENST00000541109

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCZ1

    Additional mRNA sequence: 

    AF532185.1 AK097555.1 AK292279.1 AK314516.1 AY035866.1 BC125067.1 NR_073075.1 

    7 DOTS entries:

    DT.411348  DT.99959022  DT.121197007  DT.95363660  DT.99987281  DT.92016368  DT.95365026 

    24/37 AceView cDNA sequences (see all 37):

    CD634758 AK097555 NM_033123 BM554092 AA872105 AA398866 AA620685 CD634760 
    AA781805 CD634756 AF532185 AA435866 AA824315 BG719385 BU567536 BI458829 
    BQ435684 AY035866 BX110570 BU188037 BU568375 AI935040 AA933697 AA707583 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PLCZ1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:                                                  -                                   -                             -                                   -   
    SP2:                                                  -                                   -                             -                                   -   
    SP3:                                                                                      -                             -                                       
    SP4:                                -     -           -     -     -     -     -     -     -     -     -                 -                                       
    SP5:                                                  -                                                                                                         

    ExUns: 16 ^ 17
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for PLCZ1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLCZ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAAAGGTT
    PLCZ1 Expression
    About this image


    See PLCZ1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLCZ1

    SOURCE GeneReport for Unigene cluster: Hs.97542

    UniProtKB/Swiss-Prot: PLCZ1_HUMAN, Q86YW0
    Tissue specificity: Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in
    pancreatic-duct cells from patients with cystic fibrosis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PLCZ1 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcz11 , 5 phospholipase C, zeta 11, 5 78.9(n)1
    75.7(a)1
      6 (69.77 cM)5
    1148751  NM_054066.41  NP_473407.21 
     1399896765 
    chicken
    (Gallus gallus)
    Aves PLCZ11 phospholipase C, zeta 1 67.77(n)
    62.81(a)
      418182  NM_001039273.1  NP_001034362.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    PLCZ16
    Uncharacterized protein
    55(a)
    53(a)
    possible ortholog
    1 ↔ 1
    5(9527995-9578971)
    5(9439658-9502081)


    ENSEMBL Gene Tree for PLCZ1 (if available)
    TreeFam Gene Tree for PLCZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLCZ1 gene
    PLCD42  PLCD12  PLCE12  PLCB22  PLCH12  PLCB32  PLCD32  PLCH22  
    PLCB12  PLCB42  PLCL12  PLCL22  
    11 SIMAP similar genes for PLCZ1 using alignment to 15 protein entries:     PLCZ1_HUMAN (see all proteins):
    PLCG2    PLCL1    PLCD4    PLCL2    DKFZp686K101    PLCD1
    PLCD3    PLCG1 variant protein    PLCB1    PLCB2    PLCH2

    PLCZ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1198 SNPs in PLCZ1 are shown (see all 1198)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901615291,2
    --18835615(+) CAAATC/GAATTT 2 -- ds50010--------
    rs1180325181,2
    F--18835632(+) CACTCG/ATAAAA 2 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1157383951,2
    C,F--18835671(+) CCAGTG/ACACAG 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1151374411,2
    C--18835760(+) ATTCCG/TTCCCA 2 -- ds50010--------
    rs79585791,2
    C,F,A,H--18835774(+) AAATAC/TGCAGT 2 -- ds500114Minor allele frequency- T:0.02NS EA NA CSA WA 1626
    rs14870681,2
    C,F,A,H--18835880(+) AAAAGC/TTTATA 2 -- ds500110Minor allele frequency- T:0.38NS EA NA CSA 804
    rs1816198811,2
    --18836019(+) ACTGAA/TTTATT 2 -- ds50010--------
    rs1502061031,2
    --18836144(+) GCATAA/GCTAAT 2 -- ut31 nc-transcript-variant0--------
    rs2007356651,2
    C--18836159(+) TGTCAT/CTTATC 2 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.00EU 1321
    rs1129862981,2
    C,F--18836172(+) TAGCTG/ATTATC 2 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.01CSA NA 4544

    HapMap Linkage Disequilibrium report for PLCZ1 (18836103 - 18890991 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PLCZ1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898837CNV Gain21882294


    Human Gene Mutation Database (HGMD): PLCZ1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PLCZ1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608075    OMIM disorders: --

    9 diseases for PLCZ1:    About MalaCards
    male infertility    infertility    epididymitis    cystic fibrosis
    huntington's disease    glioblastoma    pancreatitis    breast cancer
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PLCZ1:
    Male infertility

    PLCZ1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLCZ1
    Human Genome Epidemiology (HuGE) Navigator: PLCZ1 (3 documents)

    Export disorders for PLCZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLCZ1 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with PLCZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C. (PubMed id 14697805)1, 2 Zhu H.... Chang Chan H. (2003)
    4. Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes. (PubMed id 12416999)1, 2 Cox L.J....Lai F.A. (2002)
    5. NYD-SP27, a novel intrinsic decapacitation factor in sperm. (PubMed id 19252507)1, 9 Bi Y....Sha J.H. (2009)
    6. The testicular and epididymal expression profile of PL Cz in mouse and human does not support its role as a sperm-borne oocyte activati ng factor. (PubMed id 22428063)1 Aarabi M....Oko R. (2012)
    7. Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospho lipase C with implications for male infertility. (PubMed id 22086556)1 Nomikos M....Lai F.A. (2012)
    8. Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCz) from an infertile man by us e of minisequencing of individual sperm and expression in somatic cells. (PubMed id 22633260)1 Kashir J....Coward K. (2012)
    9. Motile sperm organelle morphology evaluation-selected globozoospermic human sperm with an acrosomal bud exhibits novel patterns and hi gher levels of phospholipase C zeta. (PubMed id 22940771)1 Kashir J....Coward K. (2012)
    10. Phospholipase C-z-induced Ca2+ oscillations cause coin cident cytoplasmic movements in human oocytes that failed to fertilize after int racytoplasmic sperm injection. (PubMed id 22217962)1 Swann K....Graham C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 89869 HGNC: 19218 AceView: PLCZ1 Ensembl:ENSG00000139151 euGenes: HUgn89869
    ECgene: PLCZ1 Kegg: 89869 H-InvDB: PLCZ1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLCZ1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLCZ1 gene:
    Search GeneIP for patents involving PLCZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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