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PLCZ1 Gene

protein-coding   GIFtS: 60
GCID: GC12M018736

Phospholipase C, Zeta 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase C, Zeta 11 2     PLCzeta2
Phosphoinositide Phospholipase C-Zeta-12 3     PI-Phospholipase C Zeta 12
PLC-zeta-12 3     Testis-Development Related NYD-SP272
EC 3.1.4.113 8     Phospholipase C-Zeta-13
1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Zeta-12     Testis-Development Protein NYD-SP273
NYD-SP272     

External Ids:    HGNC: 192181   Entrez Gene: 898692   Ensembl: ENSG000001391517   OMIM: 6080755   UniProtKB: Q86YW03   

Export aliases for PLCZ1 gene to outside databases

Previous GC identifers: GC12M018980 GC12M018727 GC12M018604


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLCZ1 Gene:
The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in
this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol
4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This
protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during
fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for PLCZ1 Gene:
PLCZ1 (phospholipase C, zeta 1) is a protein-coding gene. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and calcium ion binding. An important paralog of this gene is PLCD4.

UniProtKB/Swiss-Prot: PLCZ1_HUMAN, Q86YW0
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
(IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes
PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M
phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst
stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the
sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on
phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking
and function

summary for PLCZ1 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLCZ1 gene promoter:
         AML1a   Nkx2-2   Cdc5   NF-AT   NF-AT2   FOXJ2 (long isoform)   FOXJ2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCZ1 promoter sequence
   Search Chromatin IP Primers for PLCZ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p13.31

PLCZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCZ1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M018736:  view genomic region     (about GC identifiers)

Start:
18,836,103 bp from pter      End:
18,890,991 bp from pter
Size:
54,889 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLCZ1_HUMAN, Q86YW0 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1  
Size: 608 amino acids; 70411 Da
Cofactor: Calcium (By similarity)
Subunit: Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro (By similarity)
Secondary accessions: Q08AQ7 Q96J70
Alternative splicing: 3 isoforms:  Q86YW0-1   Q86YW0-2   Q86YW0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLCZ1: NX_Q86YW0

Explore proteomics data for PLCZ1 at MOPED

Selected DME Specific Peptides for PLCZ1 (Q86YW0) (see all 15)
 LSDLVIY  WNETFTF  VALNFQT  KGCRCLE 


See PLCZ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_149114.2  
ENSEMBL proteins: 
 ENSP00000438679   ENSP00000326397   ENSP00000438826   ENSP00000445287   ENSP00000445880  
 ENSP00000443320   ENSP00000266505   ENSP00000445026   ENSP00000445889   ENSP00000443762  
 ENSP00000438629   ENSP00000444611   ENSP00000440781   ENSP00000444383   ENSP00000402358  
 ENSP00000400504   ENSP00000443349  
Reactome Protein details: Q86YW0

PLCZ1 Human Recombinant Protein Products:

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Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
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antibodies-online proteins for PLCZ1 (3 products) 

 
antibodies-online peptides for PLCZ1

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antibodies-online antibodies for PLCZ1 (26 products) 

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antibodies-online kits for PLCZ1 (12 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
EFHAND: EF-hand domain containing

IUPHAR Guide to PHARMACOLOGY protein family classification: PLCzeta1
Phosphoinositide-specific phospholipase C

Selected InterPro protein domains (see all 9):
 IPR015359 PLipase_C_EF-hand-like
 IPR011992 EF-hand-dom_pair
 IPR002048 EF_hand_dom
 IPR001192 PI-PLC_fam
 IPR000909 PLipase_C_PInositol-sp_X_dom

Graphical View of Domain Structure for InterPro Entry Q86YW0

ProtoNet protein and cluster: Q86YW0

2 Blocks protein domains:
IPB000008 C2 domain
IPB000909 Phosphatidylinositol-specific phospholipase C


UniProtKB/Swiss-Prot: PLCZ1_HUMAN, Q86YW0
Domain: The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of
PLCZ1 enzyme activity (By similarity)
Domain: The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play
an important regulatory role during fertilization (By similarity)
Similarity: Contains 1 C2 domain
Similarity: Contains 1 EF-hand domain
Similarity: Contains 1 PI-PLC X-box domain
Similarity: Contains 1 PI-PLC Y-box domain


Find genes that share domains with PLCZ1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: PLCZ1_HUMAN, Q86YW0
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
(IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes
PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M
phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst
stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the
sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on
phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking
and function
Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
+ diacylglycerol

     Enzyme Number (IUBMB): EC 3.1.4.111 2

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004435phosphatidylinositol phospholipase C activity IEA--
GO:0004629phospholipase C activity ----
GO:0004871signal transducer activity IEA--
GO:0005509calcium ion binding IEA--
GO:0005515protein binding ----
     
Find genes that share ontologies with PLCZ1           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for PLCZ1:
 Decreased Salmonella enterica   Decreased Salmonella-containin  Lamellipodia and high actin ra 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for PLCZ1

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat PLCZ1

Gene Editing
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DNA2.0 Custom Protein Engineering Service for PLCZ1

Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PLCZ1 (NM_033123)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCZ1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCZ1

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCZ1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
PLCZ1_HUMAN, Q86YW0: Nucleus (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Exhibits
alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm
upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis
and mitosis (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
nucleus2
plasma membrane2
endoplasmic reticulum1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005829cytosol TAS--
GO:0048471perinuclear region of cytoplasm IEA--

Find genes that share ontologies with PLCZ1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for PLCZ1 About   (see all 30)  
See pathways by source

SuperPathContained pathways About
1Inositol phosphate metabolism (KEGG)
Inositol phosphate metabolism0.61
D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.36
Phosphatidylinositol signaling system0.61
D-myo-inositol-5-phosphate metabolism0.00
superpathway of inositol phosphate compounds0.60
2Metabolism
Metabolism0.38
Metabolic pathways0.38
3phospholipases
phospholipases0.34
Anandamide biosynthesis and metabolism0.34
4Sweet Taste Signaling
Sweet Taste Signaling0.72
Cellular Effects of Sildenafil0.46
Melatonin Signaling0.72
Sperm Motility0.37
5Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
Activation of PKA through GPCR0.71
cAMP Pathway0.77
PKA Signaling0.56


Find genes that share SuperPaths with PLCZ1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLCZ1 (see all 35)
    Antioxidant Action of Vitamin-C
Aldosterone Signaling in Epithelial Cells
UVA-Induced MAPK Signaling
PACAP Signaling
P2Y Receptor Signaling

1 GeneGo (Thomson Reuters) Pathway for PLCZ1
    Anandamide biosynthesis and metabolism

4 BioSystems Pathways for PLCZ1
    D-myo-inositol-5-phosphate metabolism
D-myo-inositol (1,4,5)-trisphosphate biosynthesis
phospholipases
superpathway of inositol phosphate compounds

1 Reactome Pathway for PLCZ1
    Synthesis of IP3 and IP4 in the cytosol

1 PharmGKB Pathway for PLCZ1
    Proton Pump Inhibitor Pathway, Pharmacodynamics

Selected Kegg Pathways  (Kegg details for PLCZ1) (see all 6):
    Inositol phosphate metabolism
Metabolic pathways
Calcium signaling pathway
Phosphatidylinositol signaling system
Oocyte meiosis

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLCZ1
Interactions:

    Search GeneGlobe Interaction Network for PLCZ1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for PLCZ1 (ENSP000002665054) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
InteractantInteraction Details
GeneCardExternal ID(s)
CDIPTENSP000002197894STRING: ENSP00000219789
IMPA1ENSP000004085264STRING: ENSP00000408526
IMPA2ENSP000002691594STRING: ENSP00000269159
INPP5BENSP000003621154STRING: ENSP00000362115
INPP5EENSP000003607774STRING: ENSP00000360777
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Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006629lipid metabolic process ----
GO:0006816calcium ion transport IEA--
GO:0007165signal transduction ----
GO:0007275multicellular organismal development IEA--
GO:0007343egg activation IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for PLCZ1 available from Tocris Bioscience    About this table
CompoundAction CAS #
FIPIPhospholipase D inhibitor[939055-18-2]
m-3M3FBSPhospholipase C activator[200933-14-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
D609Selective PC-PLC inhibitor[83373-60-8]

Selected HMDB Compounds for PLCZ1 (see all 1223)    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PLCZ1 gene: 
NM_033123.3  

Unigene Cluster for PLCZ1:

Phospholipase C, zeta 1
Hs.97542  [show with all ESTs]
Unigene Representative Sequence: NR_073075
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
ENST00000536023 ENST00000318197(uc001rdv.4) ENST00000534932 ENST00000543219
ENST00000538330(uc001rdu.1) ENST00000540270 ENST00000266505 ENST00000539875
ENST00000540421 ENST00000542762 ENST00000540515 ENST00000543242 ENST00000539072
ENST00000539207 ENST00000545129 ENST00000535429 ENST00000541966 ENST00000541109

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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat PLCZ1
Clone
Products:
     
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OriGene ORF clones in mouse, rat for PLCZ1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PLCZ1 (NM_033123)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCZ1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCZ1
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCZ1
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  QuantiFast Probe-based Assays in human, mouse, rat PLCZ1

Additional mRNA sequence: 

AF532185.1 AK097555.1 AK292279.1 AK314516.1 AY035866.1 BC125067.1 NR_073075.1 

7 DOTS entries:

DT.411348  DT.99959022  DT.121197007  DT.95363660  DT.99987281  DT.92016368  DT.95365026 

Selected AceView cDNA sequences (see all 37):

CD634758 CD634756 AK097555 AA435866 CD634760 AA781805 AA398866 AF532185 
NM_033123 AA620685 AA872105 BM554092 CD634752 BU567536 BQ435684 AA861064 
BU188037 BG719590 AA609626 AI935040 BU568375 AY035866 AA707583 BG719385 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLCZ1 (see all 12)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1:                                                  -                                   -                             -                                   -   
SP2:                                                  -                                   -                             -                                   -   
SP3:                                                                                      -                             -                                       
SP4:                                -     -           -     -     -     -     -     -     -     -     -                 -                                       
SP5:                                                  -                                                                                                         

ExUns: 16 ^ 17
SP1:            
SP2:            
SP3:            
SP4:            
SP5:            


ECgene alternative splicing isoforms for PLCZ1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PLCZ1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AACAAAGGTT
PLCZ1 Expression
About this image

PLCZ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PLCZ1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.97542

UniProtKB/Swiss-Prot: PLCZ1_HUMAN, Q86YW0
Tissue specificity: Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in
pancreatic-duct cells from patients with cystic fibrosis

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for PLCZ1 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Plcz11 , 5 phospholipase C, zeta 11, 5 78.68(n)1
75.7(a)1
  6 (69.77 cM)5
1148751  NM_054066.41  NP_473407.21 
 1399896765 
chicken
(Gallus gallus)
Aves PLCZ11 phospholipase C, zeta 1 67.83(n)
62.75(a)
  418182  NM_001039273.1  NP_001034362.1 
lizard
(Anolis carolinensis)
Reptilia PLCZ16
phospholipase C, zeta 1
53(a)
1 ↔ 1
5(9439658-9502081)


ENSEMBL Gene Tree for PLCZ1 (if available)
TreeFam Gene Tree for PLCZ1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PLCZ1 gene
PLCD42  PLCD12  PLCB22  PLCH12  PLCB32  PLCD32  PLCH22  PLCB12  
PLCB42  PLCL22  PLCL12  
11 SIMAP similar genes for PLCZ1 using alignment to 15 protein entries:     PLCZ1_HUMAN (see all proteins):
PLCG2    PLCL1    PLCD4    PLCL2    DKFZp686K101    PLCD1
PLCD3    PLCG1 variant protein    PLCH2    PLCB1    PLCB2

Find genes that share paralogs with PLCZ1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PLCZ1 (see all 1198)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1901615291,2
--18835615(+) CAAATC/GAATTT 2 -- ds50010--------
rs1180325181,2
F--18835632(+) CACTCG/ATAAAA 2 -- ds50011Minor allele frequency- A:0.01EA 120
rs1157383951,2
C,F--18835671(+) CCAGTG/ACACAG 2 -- ds50011Minor allele frequency- A:0.03WA 118
rs1151374411,2
C--18835760(+) ATTCCG/TTCCCA 2 -- ds50010--------
rs79585791,2
C,F,A,H--18835774(+) AAATAC/TGCAGT 2 -- ds500114Minor allele frequency- T:0.02NS EA NA CSA WA 1626
rs14870681,2
C,F,A,H--18835880(+) AAAAGC/TTTATA 2 -- ds500110Minor allele frequency- T:0.38NS EA NA CSA 804
rs1816198811,2
--18836019(+) ACTGAA/TTTATT 2 -- ds50010--------
rs1502061031,2
--18836144(+) GCATAA/GCTAAT 2 -- ut31 nc-transcript-variant0--------
rs2007356651,2
C--18836159(+) TGTCAT/CTTATC 2 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.00EU 1321
rs1129862981,2
C,F--18836172(+) TAGCTG/ATTATC 2 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.01CSA NA 4544

HapMap Linkage Disequilibrium report for PLCZ1 (18836103 - 18890991 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for PLCZ1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv898837CNV Gain21882294

Human Gene Mutation Database (HGMD): PLCZ1
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608075    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for PLCZ1:
Male infertility

Find genes that share disorders with PLCZ1           About GenesLikeMe

Genetic Association Database (GAD): PLCZ1
Human Genome Epidemiology (HuGE) Navigator: PLCZ1 (3 documents)

Export disorders for PLCZ1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PLCZ1 gene, integrated from 10 sources (see all 30):
(articles sorted by number of sources associating them with PLCZ1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C. (PubMed id 14697805)1, 2 Zhu H.... Chang Chan H. (Lancet 2003)
  4. Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes. (PubMed id 12416999)1, 2 Cox L.J....Lai F.A. (Reproduction 2002)
  5. NYD-SP27, a novel intrinsic decapacitation factor in sperm. (PubMed id 19252507)1, 9 Bi Y....Sha J.H. (Asian J. Androl. 2009)
  6. Sperm PLCIP: from structure to Ca2+ oscillations, egg activation and therapeutic potential. (PubMed id 24157362)1 Nomikos M....Lai F.A. (FEBS Lett. 2013)
  7. The testicular and epididymal expression profile of PLCIP in mouse and human does not support its role as a sperm-borne oocyte activating factor. (PubMed id 22428063)1 Aarabi M....Oko R. (PLoS ONE 2012)
  8. Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility. (PubMed id 22086556)1 Nomikos M....Lai F.A. (Bioessays 2012)
  9. Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCIP) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells. (PubMed id 22633260)1 Kashir J....Coward K. (Fertil. Steril. 2012)
  10. Motile sperm organelle morphology evaluation-selected globozoospermic human sperm with an acrosomal bud exhibits novel patterns and higher levels of phospholipase C zeta. (PubMed id 22940771)1 Kashir J....Coward K. (Hum. Reprod. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89869 HGNC: 19218 AceView: PLCZ1 Ensembl:ENSG00000139151 euGenes: HUgn89869
ECgene: PLCZ1 Kegg: 89869 H-InvDB: PLCZ1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PLCZ1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PLCZ1 gene:
Search GeneIP for patents involving PLCZ1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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