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Aliases for PLCXD3 Gene

Aliases for PLCXD3 Gene

  • Phosphatidylinositol Specific Phospholipase C X Domain Containing 3 2 3 5
  • Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 3 2

External Ids for PLCXD3 Gene

Summaries for PLCXD3 Gene

GeneCards Summary for PLCXD3 Gene

PLCXD3 (Phosphatidylinositol Specific Phospholipase C X Domain Containing 3) is a Protein Coding gene. Diseases associated with PLCXD3 include Creutzfeldt-Jakob Disease. Among its related pathways are Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include signal transducer activity and phosphoric diester hydrolase activity. An important paralog of this gene is PLCXD2.

Tocris Summary for PLCXD3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLCXD3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCXD3 Gene

Genomics for PLCXD3 Gene

GeneHancer (GH) Regulatory Elements for PLCXD3 Gene

Promoters and enhancers for PLCXD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I041510 Promoter/Enhancer 1 EPDnew ENCODE 550.8 +0.0 34 0.2 ZNF335 MXI1 FOXA2 SUZ12 KLF17 PRDM10 EZH2 PLCXD3 LOC105374740 GC05P041223
GH05I041509 Enhancer 0.3 FANTOM5 556.5 +0.9 901 0.1 EZH2 PLCXD3 LOC105374740 GC05P041223
GH05I040840 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 6.3 +668.8 668794 2 PKNOX1 FOXA2 FEZF1 ZNF2 YY1 ZNF766 ZNF213 FOS ATF7 REST CARD6 PRKAA1 PLCXD3 C7
GH05I040832 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.8 +676.1 676149 4.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GC05M040833 RPL37 SNORD72 PRKAA1 CARD6 TTC33 PLCXD3
GH05I041465 Enhancer 0.3 FANTOM5 14.3 +45.4 45361 0.2 PLCXD3 LOC105374740 GC05P041223
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLCXD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLCXD3 gene promoter:

Genomic Locations for PLCXD3 Gene

Genomic Locations for PLCXD3 Gene
chr5:41,306,946-41,510,628
(GRCh38/hg38)
Size:
203,683 bases
Orientation:
Minus strand
chr5:41,307,048-41,510,730
(GRCh37/hg19)

Genomic View for PLCXD3 Gene

Genes around PLCXD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCXD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCXD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCXD3 Gene

Proteins for PLCXD3 Gene

  • Protein details for PLCXD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HM9-PLCX3_HUMAN
    Recommended name:
    PI-PLC X domain-containing protein 3
    Protein Accession:
    Q63HM9
    Secondary Accessions:
    • A6NL04

    Protein attributes for PLCXD3 Gene

    Size:
    321 amino acids
    Molecular mass:
    36313 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLCXD3 Gene

Post-translational modifications for PLCXD3 Gene

No Post-translational modifications

Other Protein References for PLCXD3 Gene

No data available for DME Specific Peptides for PLCXD3 Gene

Domains & Families for PLCXD3 Gene

Gene Families for PLCXD3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PLCXD3 Gene

Suggested Antigen Peptide Sequences for PLCXD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLCXD3: view

No data available for UniProtKB/Swiss-Prot for PLCXD3 Gene

Function for PLCXD3 Gene

Phenotypes From GWAS Catalog for PLCXD3 Gene

Gene Ontology (GO) - Molecular Function for PLCXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCXD3: view
genes like me logo Genes that share phenotypes with PLCXD3: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCXD3 Gene

Localization for PLCXD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCXD3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCXD3 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLCXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PLCXD3: view

Pathways & Interactions for PLCXD3 Gene

SuperPathways for PLCXD3 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with PLCXD3: view

Pathways by source for PLCXD3 Gene

1 BioSystems pathway for PLCXD3 Gene

Interacting Proteins for PLCXD3 Gene

Selected Interacting proteins: Q63HM9-PLCX3_HUMAN for PLCXD3 Gene via IID

Symbol External ID(s) Details
PLCXD2
YWHAE

Gene Ontology (GO) - Biological Process for PLCXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLCXD3: view

No data available for SIGNOR curated interactions for PLCXD3 Gene

Drugs & Compounds for PLCXD3 Gene

(381) Additional Compounds for PLCXD3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)

(5) Tocris Compounds for PLCXD3 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCXD3: view

Transcripts for PLCXD3 Gene

mRNA/cDNA for PLCXD3 Gene

Unigene Clusters for PLCXD3 Gene

Phosphatidylinositol-specific phospholipase C, X domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCXD3 Gene

No ASD Table

Relevant External Links for PLCXD3 Gene

GeneLoc Exon Structure for
PLCXD3
ECgene alternative splicing isoforms for
PLCXD3

Expression for PLCXD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLCXD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCXD3 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.1), Brain - Cerebellar Hemisphere (x5.1), and Heart - Atrial Appendage (x5.1).

Protein differential expression in normal tissues from HIPED for PLCXD3 Gene

This gene is overexpressed in Testis (21.9), Ovary (9.5), Fetal heart (8.7), Islet of Langerhans (8.5), and Brain (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLCXD3 Gene



Protein tissue co-expression partners for PLCXD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLCXD3 Gene:

PLCXD3

SOURCE GeneReport for Unigene cluster for PLCXD3 Gene:

Hs.145404

mRNA Expression by UniProt/SwissProt for PLCXD3 Gene:

Q63HM9-PLCX3_HUMAN
Tissue specificity: Expressed at highest levels in heart. Also detected in kidney, lung, small intestine and colon. Expressed at very low levels, if any, in leukocytes, thymus and skeletal muscle.
genes like me logo Genes that share expression patterns with PLCXD3: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCXD3 Gene

Orthologs for PLCXD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCXD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCXD3 34 33
  • 99.9 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLCXD3 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLCXD3 33 34
  • 94.7 (n)
dog
(Canis familiaris)
Mammalia PLCXD3 33 34
  • 94.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PLCXD3 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcxd3 33
  • 92.83 (n)
mouse
(Mus musculus)
Mammalia Plcxd3 33 16 34
  • 91.69 (n)
chicken
(Gallus gallus)
Aves PLCXD3 34
  • 92 (a)
OneToOne
LOC100857889 33
  • 82.87 (n)
lizard
(Anolis carolinensis)
Reptilia PLCXD3 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plcxd3 33
  • 80.89 (n)
zebrafish
(Danio rerio)
Actinopterygii plcxd3 33 34
  • 74.79 (n)
wufc10h08 33
fruit fly
(Drosophila melanogaster)
Insecta CG10747 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F38E9.1 34
  • 14 (a)
OneToMany
Species where no ortholog for PLCXD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCXD3 Gene

ENSEMBL:
Gene Tree for PLCXD3 (if available)
TreeFam:
Gene Tree for PLCXD3 (if available)

Paralogs for PLCXD3 Gene

Paralogs for PLCXD3 Gene

(2) SIMAP similar genes for PLCXD3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PLCXD3 Gene

genes like me logo Genes that share paralogs with PLCXD3: view

Variants for PLCXD3 Gene

Sequence variations from dbSNP and Humsavar for PLCXD3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000048819 -- 41,320,996(-) T/C intron_variant
rs1000049801 -- 41,343,132(-) T/C intron_variant
rs1000054698 -- 41,487,453(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000068085 -- 41,423,026(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000072783 -- 41,406,576(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLCXD3 Gene

Variant ID Type Subtype PubMed ID
esv1001467 CNV deletion 20482838
esv1518058 CNV deletion 17803354
esv1936194 CNV deletion 18987734
esv2675815 CNV deletion 23128226
esv2730123 CNV deletion 23290073
esv2730124 CNV deletion 23290073
esv2730125 CNV deletion 23290073
esv3604839 CNV gain 21293372
esv3604840 CNV gain 21293372
esv3604841 CNV loss 21293372
esv3604844 CNV loss 21293372
esv3604845 CNV gain 21293372
nsv1074828 CNV deletion 25765185
nsv1140536 CNV deletion 24896259
nsv327751 CNV deletion 16902084
nsv328702 CNV deletion 16902084
nsv474969 CNV novel sequence insertion 20440878
nsv476576 CNV novel sequence insertion 20440878
nsv482997 CNV loss 15286789
nsv830269 CNV gain 17160897
nsv955836 CNV deletion 24416366

Variation tolerance for PLCXD3 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLCXD3 Gene

Human Gene Mutation Database (HGMD)
PLCXD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLCXD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCXD3 Gene

Disorders for PLCXD3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLCXD3 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
creutzfeldt-jakob disease
  • cjd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLCXD3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLCXD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLCXD3 Gene

Publications for PLCXD3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Variants of PLCXD3 are not associated with variant or sporadic Creutzfeldt-Jakob disease in a large international study. (PMID: 27055460) Balendra R … Mead S (BMC medical genetics 2016) 3 58
  3. Cloning, tissue distribution and sub-cellular localisation of phospholipase C X-domain containing protein (PLCXD) isoforms. (PMID: 22732399) Gellatly SA … Cramb G (Biochemical and biophysical research communications 2012) 4 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs JB … Dupuis J (BMC medical genetics 2007) 44 58

Products for PLCXD3 Gene

Sources for PLCXD3 Gene

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