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Aliases for PLCXD3 Gene

Aliases for PLCXD3 Gene

  • Phosphatidylinositol Specific Phospholipase C X Domain Containing 3 2 3
  • Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 3 2 5

External Ids for PLCXD3 Gene

Summaries for PLCXD3 Gene

GeneCards Summary for PLCXD3 Gene

PLCXD3 (Phosphatidylinositol Specific Phospholipase C X Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and phosphoric diester hydrolase activity. An important paralog of this gene is PLCXD2.

Tocris Summary for PLCXD3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCXD3 Gene

Genomics for PLCXD3 Gene

Regulatory Elements for PLCXD3 Gene

Promoters for PLCXD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLCXD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCXD3 Gene

Chromosome:
5
Start:
41,306,946 bp from pter
End:
41,510,628 bp from pter
Size:
203,683 bases
Orientation:
Minus strand

Genomic View for PLCXD3 Gene

Genes around PLCXD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCXD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCXD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCXD3 Gene

Proteins for PLCXD3 Gene

  • Protein details for PLCXD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HM9-PLCX3_HUMAN
    Recommended name:
    PI-PLC X domain-containing protein 3
    Protein Accession:
    Q63HM9
    Secondary Accessions:
    • A6NL04

    Protein attributes for PLCXD3 Gene

    Size:
    321 amino acids
    Molecular mass:
    36313 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLCXD3 Gene

Proteomics data for PLCXD3 Gene at MOPED

Post-translational modifications for PLCXD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCXD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLCXD3 Gene

Domains & Families for PLCXD3 Gene

Protein Domains for PLCXD3 Gene

Suggested Antigen Peptide Sequences for PLCXD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q63HM9

UniProtKB/Swiss-Prot:

PLCX3_HUMAN :
  • Contains 1 PI-PLC X-box domain.
Domain:
  • Contains 1 PI-PLC X-box domain.
genes like me logo Genes that share domains with PLCXD3: view

No data available for Gene Families for PLCXD3 Gene

Function for PLCXD3 Gene

genes like me logo Genes that share phenotypes with PLCXD3: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCXD3 Gene

Localization for PLCXD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCXD3 Gene COMPARTMENTS Subcellular localization image for PLCXD3 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLCXD3 Gene

Pathways & Interactions for PLCXD3 Gene

SuperPathways for PLCXD3 Gene

No Data Available

Interacting Proteins for PLCXD3 Gene

Selected Interacting proteins: Q63HM9-PLCX3_HUMAN for PLCXD3 Gene via I2D

Symbol External ID(s) Details
PRKAR1A

Gene Ontology (GO) - Biological Process for PLCXD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with PLCXD3: view

No data available for Pathways by source and SIGNOR curated interactions for PLCXD3 Gene

Drugs & Compounds for PLCXD3 Gene

(1) Drugs for PLCXD3 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D609 Pharma PC-PLC inhibitor, Selective PC-PLC inhibitor 0

(383) Additional Compounds for PLCXD3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with PLCXD3: view

Transcripts for PLCXD3 Gene

mRNA/cDNA for PLCXD3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLCXD3 Gene

Phosphatidylinositol-specific phospholipase C, X domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCXD3 Gene

No ASD Table

Relevant External Links for PLCXD3 Gene

GeneLoc Exon Structure for
PLCXD3
ECgene alternative splicing isoforms for
PLCXD3

Expression for PLCXD3 Gene

mRNA expression in normal human tissues for PLCXD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCXD3 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.1), Brain - Cerebellar Hemisphere (x5.1), and Heart - Atrial Appendage (x5.1).

Protein differential expression in normal tissues from HIPED for PLCXD3 Gene

This gene is overexpressed in Testis (21.9), Ovary (9.5), Fetal heart (8.7), Islet of Langerhans (8.5), and Brain (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLCXD3 Gene



SOURCE GeneReport for Unigene cluster for PLCXD3 Gene Hs.145404

genes like me logo Genes that share expression patterns with PLCXD3: view

Protein tissue co-expression partners for PLCXD3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PLCXD3 Gene

Orthologs for PLCXD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCXD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCXD3 35
  • 99.9 (n)
  • 100 (a)
PLCXD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLCXD3 36
  • 99 (a)
OneToOne
PLCXD3 35
  • 94.7 (n)
  • 98.75 (a)
dog
(Canis familiaris)
Mammalia PLCXD3 35
  • 94.5 (n)
  • 98.44 (a)
PLCXD3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcxd3 16
Plcxd3 35
  • 91.69 (n)
  • 98.44 (a)
Plcxd3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLCXD3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLCXD3 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcxd3 35
  • 92.83 (n)
  • 98.44 (a)
chicken
(Gallus gallus)
Aves LOC100857889 35
  • 82.87 (n)
  • 92.52 (a)
PLCXD3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCXD3 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plcxd3 35
  • 80.89 (n)
  • 88.47 (a)
zebrafish
(Danio rerio)
Actinopterygii plcxd3 36
  • 81 (a)
OneToOne
plcxd3 35
  • 74.79 (n)
  • 81.56 (a)
wufc10h08 35
fruit fly
(Drosophila melanogaster)
Insecta CG10747 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F38E9.1 36
  • 14 (a)
OneToMany
Species with no ortholog for PLCXD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCXD3 Gene

ENSEMBL:
Gene Tree for PLCXD3 (if available)
TreeFam:
Gene Tree for PLCXD3 (if available)

Paralogs for PLCXD3 Gene

Paralogs for PLCXD3 Gene

(2) SIMAP similar genes for PLCXD3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PLCXD3 Gene

genes like me logo Genes that share paralogs with PLCXD3: view

Variants for PLCXD3 Gene

Sequence variations from dbSNP and Humsavar for PLCXD3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs161087 -- 41,366,776(+) cagca(A/T)gcatt intron-variant
rs161088 -- 41,368,378(+) gcaca(A/T)taatt intron-variant
rs178466 -- 41,418,817(+) AGAAG(A/G)GTGTG intron-variant
rs191162 -- 41,473,490(+) TGAGA(C/T)GAGTC intron-variant
rs172753 -- 41,473,763(+) CATTA(C/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCXD3 Gene

Variant ID Type Subtype PubMed ID
nsv482997 CNV Loss 15286789
nsv830269 CNV Gain 17160897
esv2730123 CNV Deletion 23290073
esv1936194 CNV Deletion 18987734
nsv327751 CNV Loss 16902084
esv2730124 CNV Deletion 23290073
esv1001467 CNV Deletion 20482838
esv1518058 CNV Deletion 17803354
nsv328702 CNV Loss 16902084
esv2675815 CNV Deletion 23128226
esv2730125 CNV Deletion 23290073

Variation tolerance for PLCXD3 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLCXD3 Gene

HapMap Linkage Disequilibrium report
PLCXD3
Human Gene Mutation Database (HGMD)
PLCXD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCXD3 Gene

Disorders for PLCXD3 Gene

Relevant External Links for PLCXD3

Genetic Association Database (GAD)
PLCXD3
Human Genome Epidemiology (HuGE) Navigator
PLCXD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLCXD3

No disorders were found for PLCXD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCXD3 Gene

Publications for PLCXD3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67

Products for PLCXD3 Gene

Sources for PLCXD3 Gene

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