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Aliases for PLCXD2 Gene

Aliases for PLCXD2 Gene

  • Phosphatidylinositol Specific Phospholipase C X Domain Containing 2 2 3
  • Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 2 2 5

External Ids for PLCXD2 Gene

Previous GeneCards Identifiers for PLCXD2 Gene

  • GC03P112876
  • GC03P111393
  • GC03P108768

Summaries for PLCXD2 Gene

GeneCards Summary for PLCXD2 Gene

PLCXD2 (Phosphatidylinositol Specific Phospholipase C X Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and phosphoric diester hydrolase activity. An important paralog of this gene is PLCXD1.

Tocris Summary for PLCXD2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCXD2 Gene

Genomics for PLCXD2 Gene

Regulatory Elements for PLCXD2 Gene

Promoters for PLCXD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLCXD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCXD2 Gene

Chromosome:
3
Start:
111,674,676 bp from pter
End:
111,846,447 bp from pter
Size:
171,772 bases
Orientation:
Plus strand

Genomic View for PLCXD2 Gene

Genes around PLCXD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCXD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCXD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCXD2 Gene

Proteins for PLCXD2 Gene

  • Protein details for PLCXD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VAA5-PLCX2_HUMAN
    Recommended name:
    PI-PLC X domain-containing protein 2
    Protein Accession:
    Q0VAA5
    Secondary Accessions:
    • Q96N12

    Protein attributes for PLCXD2 Gene

    Size:
    305 amino acids
    Molecular mass:
    34777 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLCXD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCXD2 Gene

Proteomics data for PLCXD2 Gene at MOPED

Post-translational modifications for PLCXD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCXD2 Gene

No data available for DME Specific Peptides for PLCXD2 Gene

Domains & Families for PLCXD2 Gene

Protein Domains for PLCXD2 Gene

Suggested Antigen Peptide Sequences for PLCXD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0VAA5

UniProtKB/Swiss-Prot:

PLCX2_HUMAN :
  • Contains 1 PI-PLC X-box domain.
Domain:
  • Contains 1 PI-PLC X-box domain.
genes like me logo Genes that share domains with PLCXD2: view

No data available for Gene Families for PLCXD2 Gene

Function for PLCXD2 Gene

genes like me logo Genes that share phenotypes with PLCXD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCXD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCXD2 Gene

Localization for PLCXD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCXD2 Gene COMPARTMENTS Subcellular localization image for PLCXD2 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLCXD2 Gene

Pathways & Interactions for PLCXD2 Gene

SuperPathways for PLCXD2 Gene

No Data Available

Interacting Proteins for PLCXD2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000420686%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000420686 for PLCXD2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for PLCXD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with PLCXD2: view

No data available for Pathways by source and SIGNOR curated interactions for PLCXD2 Gene

Drugs & Compounds for PLCXD2 Gene

(1) Drugs for PLCXD2 Gene - From: ApexBio and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D609 Pharma PC-PLC inhibitor, Selective PC-PLC inhibitor 0

(383) Additional Compounds for PLCXD2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)

(5) Tocris Compounds for PLCXD2 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
RHC 80267 Diacylglycerol lipase inhibitor 83654-05-1
U 73122 Phospholipase C inhibitor 112648-68-7

(1) ApexBio Compounds for PLCXD2 Gene

Compound Action Cas Number
D609 PC-PLC inhibitor 83373-60-8
genes like me logo Genes that share compounds with PLCXD2: view

Transcripts for PLCXD2 Gene

Unigene Clusters for PLCXD2 Gene

Phosphatidylinositol-specific phospholipase C, X domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCXD2 Gene

No ASD Table

Relevant External Links for PLCXD2 Gene

GeneLoc Exon Structure for
PLCXD2
ECgene alternative splicing isoforms for
PLCXD2

Expression for PLCXD2 Gene

mRNA expression in normal human tissues for PLCXD2 Gene

Protein differential expression in normal tissues from HIPED for PLCXD2 Gene

This gene is overexpressed in Liver (48.3) and Kidney (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLCXD2 Gene



SOURCE GeneReport for Unigene cluster for PLCXD2 Gene Hs.477114

genes like me logo Genes that share expression patterns with PLCXD2: view

Protein tissue co-expression partners for PLCXD2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLCXD2 Gene

Orthologs for PLCXD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCXD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLCXD2 35
  • 89.85 (n)
  • 91 (a)
PLCXD2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCXD2 35
  • 91.95 (n)
  • 94.48 (a)
PLCXD2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcxd2 35
  • 89.54 (n)
  • 94.14 (a)
Plcxd2 16
Plcxd2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLCXD2 35
  • 99.54 (n)
  • 99.31 (a)
PLCXD2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcxd2 35
  • 89.54 (n)
  • 95.17 (a)
oppossum
(Monodelphis domestica)
Mammalia PLCXD2 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLCXD2 35
  • 71.81 (n)
  • 77.61 (a)
PLCXD2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCXD2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496710 35
  • 67.56 (n)
  • 73.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53544 35
zebrafish
(Danio rerio)
Actinopterygii LOC559936 35
  • 64.04 (n)
  • 66.29 (a)
PLCXD2 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010008 35
  • 46.48 (n)
  • 36.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10747 35
  • 48.15 (n)
  • 40.74 (a)
CG10747 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F38E9.1 35
  • 43.27 (n)
  • 32.24 (a)
F38E9.1 36
  • 14 (a)
OneToMany
Species with no ortholog for PLCXD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCXD2 Gene

ENSEMBL:
Gene Tree for PLCXD2 (if available)
TreeFam:
Gene Tree for PLCXD2 (if available)

Paralogs for PLCXD2 Gene

Paralogs for PLCXD2 Gene

(2) SIMAP similar genes for PLCXD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLCXD2: view

Variants for PLCXD2 Gene

Sequence variations from dbSNP and Humsavar for PLCXD2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs867293 -- 111,681,651(+) TCCAC(C/T)GGGCC intron-variant
rs951338 -- 111,714,968(+) AGTTT(C/T)AGGTT intron-variant
rs882591 -- 111,729,437(-) ATCCA(A/G)GACAT intron-variant
rs1105448 -- 111,730,097(+) TGAGT(A/G)TAGAA intron-variant
rs938218 -- 111,684,981(+) GCATT(A/C)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCXD2 Gene

Variant ID Type Subtype PubMed ID
nsv460821 CNV Gain 19166990
nsv3947 CNV Insertion 18451855
nsv829676 CNV Gain 17160897
esv2635192 CNV Insertion 19546169
esv2668352 CNV Deletion 23128226
esv2725775 CNV Deletion 23290073
esv2725776 CNV Deletion 23290073
esv2725777 CNV Deletion 23290073
esv1055295 CNV Deletion 17803354

Variation tolerance for PLCXD2 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLCXD2 Gene

HapMap Linkage Disequilibrium report
PLCXD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCXD2 Gene

Disorders for PLCXD2 Gene

Relevant External Links for PLCXD2

Genetic Association Database (GAD)
PLCXD2
Human Genome Epidemiology (HuGE) Navigator
PLCXD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLCXD2

No disorders were found for PLCXD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCXD2 Gene

Publications for PLCXD2 Gene

  1. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 48 67
  2. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for PLCXD2 Gene

Sources for PLCXD2 Gene

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