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Aliases for PLCXD2 Gene

Aliases for PLCXD2 Gene

  • Phosphatidylinositol Specific Phospholipase C X Domain Containing 2 2 3 5
  • Phosphatidylinositol-Specific Phospholipase C, X Domain Containing 2 2

External Ids for PLCXD2 Gene

Previous GeneCards Identifiers for PLCXD2 Gene

  • GC03P112876
  • GC03P111393
  • GC03P108768

Summaries for PLCXD2 Gene

GeneCards Summary for PLCXD2 Gene

PLCXD2 (Phosphatidylinositol Specific Phospholipase C X Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and phosphoric diester hydrolase activity. An important paralog of this gene is PLCXD3.

Tocris Summary for PLCXD2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLCXD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCXD2 Gene

Genomics for PLCXD2 Gene

Regulatory Elements for PLCXD2 Gene

Enhancers for PLCXD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H111759 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +87.9 87934 5.7 ELF3 TBP RAD21 RARA YY1 FOS ATF7 CREM IKZF2 THAP11 PLCXD2 PHLDB2 LOC105374040
GH03H111858 1.7 FANTOM5 ENCODE dbSUPER 10.3 +187.9 187934 8.6 SIN3A FEZF1 BRCA1 ZNF2 YY1 GLIS2 ATF7 RUNX3 SP3 SP5 ABHD10 PLCXD2 TAGLN3 PLCXD2-AS1 PHLDB2 SLC9C1 LOC105374040 GC03P111896
GH03H111799 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +127.6 127644 4.7 TBP PKNOX1 JUN SIN3A MAX BRCA1 RAD21 RFX5 GATA3 POLR2A PLCXD2 PHLDB2 LOC105374040
GH03H111931 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +260.1 260092 7.2 TBP FOXA2 JUN FEZF1 ZNF664 HIC1 POLR2A FOS MAFK TCF7L2 ABHD10 PLCXD2 PLCXD2-AS1 SLC35A5 PHLDB2 GC03P111896
GH03H111965 1.3 Ensembl ENCODE dbSUPER 10.4 +292.5 292498 2.5 ELF3 CTCF ZSCAN4 MAX ZNF384 RAD21 ZNF7 ZNF664 ZNF366 SCRT2 ABHD10 PLCXD2 GC03P111896
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLCXD2 on UCSC Golden Path with GeneCards custom track

Promoters for PLCXD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000156449 924 401 SCRT2 ZNF398

Genomic Locations for PLCXD2 Gene

Genomic Locations for PLCXD2 Gene
171,772 bases
Plus strand

Genomic View for PLCXD2 Gene

Genes around PLCXD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCXD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCXD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCXD2 Gene

Proteins for PLCXD2 Gene

  • Protein details for PLCXD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PI-PLC X domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q96N12

    Protein attributes for PLCXD2 Gene

    305 amino acids
    Molecular mass:
    34777 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLCXD2 Gene


neXtProt entry for PLCXD2 Gene

Post-translational modifications for PLCXD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCXD2 Gene

No data available for DME Specific Peptides for PLCXD2 Gene

Domains & Families for PLCXD2 Gene

Gene Families for PLCXD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PLCXD2 Gene

Suggested Antigen Peptide Sequences for PLCXD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLCXD2: view

No data available for UniProtKB/Swiss-Prot for PLCXD2 Gene

Function for PLCXD2 Gene

Phenotypes From GWAS Catalog for PLCXD2 Gene

Gene Ontology (GO) - Molecular Function for PLCXD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCXD2: view
genes like me logo Genes that share phenotypes with PLCXD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCXD2 Gene

Localization for PLCXD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCXD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCXD2 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLCXD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PLCXD2: view

Pathways & Interactions for PLCXD2 Gene

SuperPathways for PLCXD2 Gene

No Data Available

Interacting Proteins for PLCXD2 Gene

Selected Interacting proteins: Q0VAA5-PLCX2_HUMAN for PLCXD2 Gene via IID

Gene Ontology (GO) - Biological Process for PLCXD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLCXD2: view

No data available for Pathways by source and SIGNOR curated interactions for PLCXD2 Gene

Drugs & Compounds for PLCXD2 Gene

(1) Drugs for PLCXD2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D609 Pharma PC-PLC inhibitor 0

(381) Additional Compounds for PLCXD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)

(5) Tocris Compounds for PLCXD2 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7

(1) ApexBio Compounds for PLCXD2 Gene

Compound Action Cas Number
D609 PC-PLC inhibitor 83373-60-8
genes like me logo Genes that share compounds with PLCXD2: view

Drug Products

Transcripts for PLCXD2 Gene

Unigene Clusters for PLCXD2 Gene

Phosphatidylinositol-specific phospholipase C, X domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCXD2 Gene

No ASD Table

Relevant External Links for PLCXD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLCXD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLCXD2 Gene

Protein differential expression in normal tissues from HIPED for PLCXD2 Gene

This gene is overexpressed in Liver (48.3) and Kidney (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLCXD2 Gene

Protein tissue co-expression partners for PLCXD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLCXD2 Gene:


SOURCE GeneReport for Unigene cluster for PLCXD2 Gene:


mRNA Expression by UniProt/SwissProt for PLCXD2 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PLCXD2 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with PLCXD2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCXD2 Gene

Orthologs for PLCXD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCXD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLCXD2 33 34
  • 99.54 (n)
(Canis familiaris)
Mammalia PLCXD2 33 34
  • 91.95 (n)
(Bos Taurus)
Mammalia PLCXD2 33 34
  • 89.85 (n)
(Mus musculus)
Mammalia Plcxd2 33 16 34
  • 89.54 (n)
(Rattus norvegicus)
Mammalia Plcxd2 33
  • 89.54 (n)
(Monodelphis domestica)
Mammalia PLCXD2 34
  • 73 (a)
(Gallus gallus)
Aves PLCXD2 33 34
  • 71.81 (n)
(Anolis carolinensis)
Reptilia PLCXD2 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496710 33
  • 67.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53544 33
(Danio rerio)
Actinopterygii LOC559936 33
  • 64.04 (n)
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10747 33 34
  • 48.15 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010008 33
  • 46.48 (n)
(Caenorhabditis elegans)
Secernentea F38E9.1 33 34
  • 43.27 (n)
Species where no ortholog for PLCXD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCXD2 Gene

Gene Tree for PLCXD2 (if available)
Gene Tree for PLCXD2 (if available)

Paralogs for PLCXD2 Gene

Paralogs for PLCXD2 Gene

(2) SIMAP similar genes for PLCXD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLCXD2: view

Variants for PLCXD2 Gene

Sequence variations from dbSNP and Humsavar for PLCXD2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000026746 -- 111,840,439(+) TAATG(G/T)GGTGT intron-variant
rs1000027355 -- 111,810,073(+) GTTAT(A/G)GTTAA intron-variant
rs1000049064 -- 111,721,398(+) GATTG(C/T)TGGAT intron-variant
rs1000066133 -- 111,818,607(+) TGGGT(C/G)TTACA intron-variant
rs1000083114 -- 111,715,528(+) ACTAA(C/T)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCXD2 Gene

Variant ID Type Subtype PubMed ID
nsv829676 CNV gain 17160897
nsv591290 CNV gain 21841781
nsv591275 CNV gain 21841781
nsv460821 CNV gain 19166990
nsv3947 CNV insertion 18451855
nsv1150720 CNV deletion 26484159
nsv1140345 OTHER inversion 24896259
nsv1132924 CNV insertion 24896259
nsv1129236 CNV insertion 24896259
nsv1074616 CNV deletion 25765185
esv3597399 CNV loss 21293372
esv2725777 CNV deletion 23290073
esv2725776 CNV deletion 23290073
esv2725775 CNV deletion 23290073
esv2668352 CNV deletion 23128226
esv2635192 CNV insertion 19546169
esv1055295 CNV deletion 17803354

Variation tolerance for PLCXD2 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLCXD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCXD2 Gene

Disorders for PLCXD2 Gene

Relevant External Links for PLCXD2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLCXD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCXD2 Gene

Publications for PLCXD2 Gene

  1. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli ET … Goldstein DB (European journal of human genetics : EJHG 2010) 3 45 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for PLCXD2 Gene

Sources for PLCXD2 Gene

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