Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PLCXD1 Gene

protein-coding   GIFtS: 48
GCID: GC0XP000192

Phosphatidylinositol-Specific Phospholipase C, X Domain...

  Search for PLCXD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phosphatidylinositol-Specific Phospholipase C, X Domain Containing
11 2
PI-PLC X Domain-Containing Protein 12

External Ids:    HGNC: 231481   Entrez Gene: 553442   Ensembl: ENSG000001823787   UniProtKB: Q9NUJ73   

Export aliases for PLCXD1 gene to outside databases

Previous GC identifers: GC0YP000133 GC0XP000132


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PLCXD1 Gene:
This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y.
Alternate splicing results in multiple transcript variants. (provided by RefSeq, Mar 2010)

GeneCards Summary for PLCXD1 Gene:
PLCXD1 (phosphatidylinositol-specific phospholipase C, X domain containing 1) is a protein-coding gene. GO annotations related to this gene include phosphoric diester hydrolase activity. An important paralog of this gene is PLCXD3.

summary for PLCXD1 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLCXD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_187358.1  NC_000024.9  NT_167201.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLCXD1 gene promoter:
         AREB6   NF-kappaB2   MyoD   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCXD1 promoter sequence
   Search Chromatin IP Primers for PLCXD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCXD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33; Yp11.32   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.33 and Yp11.32

PLCXD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCXD1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP000192:  view genomic region     (about GC identifiers)

Start:
192,989 bp from pter      End:
220,023 bp from pter
Size:
27,035 bases      Orientation:
plus strand

1 alternative location:
ChrY+ 142,991-170,023     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PLCX1_HUMAN, Q9NUJ7 (See protein sequence)
Recommended Name: PI-PLC X domain-containing protein 1  
Size: 323 amino acids; 36668 Da
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Sequence caution: Sequence=CAM28359.1; Type=Erroneous gene model prediction; Sequence=CAM28360.1; Type=Erroneous
gene model prediction;
Secondary accessions: A2BH51 A2BH52

Explore the universe of human proteins at neXtProt for PLCXD1: NX_Q9NUJ7

Explore proteomics data for PLCXD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys227
  • Modification sites at PhosphoSitePlus

  • See PLCXD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060860.1  
    ENSEMBL proteins: 
     ENSP00000381976   ENSP00000394848   ENSP00000412018   ENSP00000371073   ENSP00000400904  
     ENSP00000408558   ENSP00000399510   ENSP00000405307   ENSP00000414181   ENSP00000371079  

    PLCXD1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PLCXD1
    OriGene Protein Over-expression Lysate for PLCXD1
    OriGene MassSpec for PLCXD1
    OriGene Custom Protein Services for PLCXD1
    GenScript Custom Purified and Recombinant Proteins Services for PLCXD1
    Novus Biologicals PLCXD1 Protein
    Novus Biologicals PLCXD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLCXD1

     
    Search eBioscience for Proteins for PLCXD1 

    PLCXD1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PLCXD1
    OriGene Custom Antibody Services for PLCXD1
    Novus Biologicals PLCXD1 Antibodies
    Abcam antibodies for PLCXD1
    Cloud-Clone Corp. Antibodies for PLCXD1
    Search ThermoFisher Antibodies for PLCXD1
    LSBio Antibodies in human, mouse, rat for PLCXD1

    PLCXD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PLCXD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PLCXD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PLCXD1
    Cloud-Clone Corp. CLIAs for PLCXD1
    Search eBioscience for ELISAs for PLCXD1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PAR1: Pseudoautosomal regions / PAR1

    2 InterPro protein domains:
     IPR000909 PLipase_C_PInositol-sp_X_dom
     IPR017946 PLC-like_Pdiesterase_TIM-brl

    Graphical View of Domain Structure for InterPro Entry Q9NUJ7

    ProtoNet protein and cluster: Q9NUJ7

    UniProtKB/Swiss-Prot: PLCX1_HUMAN, Q9NUJ7
    Similarity: Contains 1 PI-PLC X-box domain


    Find genes that share domains with PLCXD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008081phosphoric diester hydrolase activity IEA--
         
    Find genes that share ontologies with PLCXD1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PLCXD1:
     Decreased melanin production 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLCXD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLCXD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLCXD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLCXD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLCXD1:
    hsa-let-7e-5p (MIRT051669), hsa-mir-98-5p (MIRT027825), hsa-mir-296-3p (MIRT038343)

    Block miRNA regulation of human, mouse, rat PLCXD1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PLCXD1
    SwitchGear 3'UTR luciferase reporter plasmidPLCXD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLCXD1
    Predesigned siRNA for gene silencing in human, mouse, rat PLCXD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLCXD1

    Clone
    Products:
         
    OriGene clones in human, mouse for PLCXD1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLCXD1 (NM_018390)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCXD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCXD1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLCXD1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PLCXD1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCXD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular1
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLCXD1
    Interactions:

        Search GeneGlobe Interaction Network for PLCXD1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PLCXD1 (ENSP000003710734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process IEA--

    Find genes that share ontologies with PLCXD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PLCXD1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLCXD1 (see all 379)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----
    PI(16:0/20:0)PI(16:0/20:0) (see all 8)----
    PI(16:0/20:2(11Z,14Z))Phosphatidylinositol(16:0/20:2n6) (see all 14)----
    PI(16:0/20:3(5Z,8Z,11Z))Phosphatidylinositol(36:3) (see all 14)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PLCXD1 gene: 
    NM_018390.3  

    Unigene Cluster for PLCXD1:

    Phosphatidylinositol-specific phospholipase C, X domain containing 1
    Hs.522568  [show with all ESTs]
    Unigene Representative Sequence: NM_018390
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399012(uc011mgx.2) ENST00000484611 ENST00000430923 ENST00000445062
    ENST00000381657(uc004cpc.3) ENST00000429181 ENST00000443019 ENST00000415337
    ENST00000447472 ENST00000448477 ENST00000381663
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PLCXD1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PLCXD1
    SwitchGear 3'UTR luciferase reporter plasmidPLCXD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PLCXD1
    Predesigned siRNA for gene silencing in human, mouse, rat PLCXD1
    Clone
    Products:
         
    OriGene clones in human, mouse for PLCXD1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLCXD1 (NM_018390)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCXD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCXD1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PLCXD1
    OriGene qSTAR qPCR primer pairs in human, mouse for PLCXD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCXD1
      QuantiTect SYBR Green Assays in human, mouse, rat PLCXD1
      QuantiFast Probe-based Assays in human, mouse, rat PLCXD1

    Additional mRNA sequence: 

    AK091006.1 AK097346.1 BC000888.1 BC032072.1 BC033659.1 BC064136.1 NR_028057.1 

    22 DOTS entries:

    DT.100017065  DT.100746978  DT.109707  DT.92425363  DT.91745747  DT.92425362  DT.92425365  DT.95135750 
    DT.120651324  DT.121280248  DT.121280268  DT.95262939  DT.100746979  DT.120651283  DT.120651285  DT.121280225 
    DT.121280240  DT.121280257  DT.121280267  DT.305610  DT.95303162  DT.99971132 

    Selected AceView cDNA sequences (see all 99):

    BC064136 AA904871 CA425577 AA922254 AI858768 AW576173 BE882372 BC005028 
    AI632862 AI972002 AA972177 AI266721 AI668812 AI688268 AA975847 AA894521 
    BU189701 AK002185 AI742342 AA905820 CK429341 AI810122 AW016907 BQ882958 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PLCXD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCAATAGG
    PLCXD1 Expression
    About this image


    PLCXD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Trachea
             Alveolar type II cells
     
     Kidney (Urinary System)
             Ureteric Bud
    PLCXD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLCXD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522568
        Custom PCR Arrays for PLCXD1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PLCXD1
    OriGene qSTAR qPCR primer pairs in human, mouse for PLCXD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCXD1
    QuantiTect SYBR Green Assays in human, mouse, rat PLCXD1
    QuantiFast Probe-based Assays in human, mouse, rat PLCXD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCXD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PLCXD1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PLCXD11 phosphatidylinositol-specific phospholipase C, X domain more 61.92(n)
    61.17(a)
      418673  NM_001128637.1  NP_001122109.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLCXD16
    phosphatidylinositol-specific phospholipase C, X d...
    52(a)
    1 ↔ 1
    3(112157063-112171512)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia plcxd11 phosphatidylinositol-specific phospholipase C, X domain more 55.52(n)
    50(a)
      100488047  XM_002936983.2  XP_002937029.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5634891 PI-PLC X domain-containing protein 1-like 55.56(n)
    51(a)
      563489  XM_686850.3  XP_691942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG107476
    --
    26(a)
    1 → many
    2L(20089636-20091348)
    worm
    (Caenorhabditis elegans)
    Secernentea F38E9.16
    Protein F38E9.1 (F38E9.1) mRNA, complete cds
    13(a)
    1 → many
    X(16471058-16474664) WBGene00018184
            Species with no ortholog for PLCXD1

    ENSEMBL Gene Tree for PLCXD1 (if available)
    TreeFam Gene Tree for PLCXD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PLCXD1 gene
    PLCXD32  PLCXD22  
    2 SIMAP similar genes for PLCXD1 using alignment to 3 protein entries:     PLCX1_HUMAN (see all proteins):
    PLCXD3    PLCXD2

    Find genes that share paralogs with PLCXD1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PLCXD1
    PGOHUM00000249154


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PLCXD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1006189CNV Deletion20482838
    esv2663649CNV Deletion23128226
    esv2658490CNV Deletion23128226
    esv27600CNV Gain+Loss19812545

    Locus Specific Mutation Databases (LSDB): PLCXD1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLCXD1
    DNA2.0 Custom Variant and Variant Library Synthesis for PLCXD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PLCXD1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with PLCXD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Characterization of the bovine pseudoautosomal region and comparison with sheep, goat, and other mammalian pseudoautosomal regions. (PubMed id 20016163)1 Das P.J....Raudsepp T. (Cytogenet. Genome Res. 2009)
    9. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PubMed id 19377476)1 Tarpey P.S.... Stratton M.R. (Nat. Genet. 2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55344 HGNC: 23148 AceView: PLCXD1 Ensembl:ENSG00000182378 euGenes: HUgn55344
    ECgene: PLCXD1 H-InvDB: PLCXD1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PLCXD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PLCXD1 gene:
    Search GeneIP for patents involving PLCXD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PLCXD1   OriGene RNAi products in human, mouse, rat for PLCXD1  
     OriGene qPCR primer pairs and template standards for PLCXD1   OriGene Protein Over-expression Lysate for PLCXD1  
     OriGene MassSpec something-or-other for PLCXD1   OriGene clones in human, mouse for PLCXD1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PLCXD1   OriGene Purified Protein for PLCXD1  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PLCXD1   OriGene Custom Protein Services for PLCXD1  

     
     
     Block miRNA regulation of human, mouse, rat PLCXD1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PLCXD1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCXD1 Predesigned siRNA for gene silencing in human, mouse, rat PLCXD1
     QuantiFast Probe-based Assays in human, mouse, rat PLCXD1 QuantiTect SYBR Green Assays in human, mouse, rat PLCXD1
     Custom PCR Arrays for PLCXD1 Search Chromatin IP Primers for PLCXD1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCXD1  Search GeneGlobe Interaction Network for PLCXD1
     Regulatory tfbs in PLCXD1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PLCXD1 GenScript cDNA clones with any tag delivered in your preferred vector for PLCXD1
     GenScript Custom Assay Services for PLCXD1 GenScript Custom overexpressing Cell Line Services for PLCXD1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for PLCXD1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PLCXD1 antibodies
     PLCXD1 proteins
     PLCXD1 lysates
     Antibodies for PLCXD1
     See all of Abcam's Antibodies, Kits and Proteins for PLCXD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PLCXD1
     Antibodies for PLCXD1
     ELISAs for PLCXD1
     CLIAs for PLCXD1



     Browse ESI BIO Cell Lines and PureStem Progenitors for PLCXD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCXD1
     SwitchGear 3'UTR luciferase reporter plasmids for PLCXD1
     SwitchGear Promoter luciferase reporter plasmids for PLCXD1
     Search ThermoFisher Antibodies for PLCXD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCXD1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLCXD1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLCXD1
     LSBio Antibodies in human, mouse, rat for PLCXD1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PLCXD1
      Search eBioscience for proteins for PLCXD1
      Search eBioscience for elisas for PLCXD1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PLCXD1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4