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Aliases for PLCL2 Gene

Aliases for PLCL2 Gene

  • Phospholipase C Like 2 2 3 5
  • Phospholipase C-Epsilon-2 3 4
  • Phospholipase C-L2 3 4
  • PLC-Epsilon-2 3 4
  • PLC-L(2) 3 4
  • PLC-L2 3 4
  • PLCE2 3 4
  • Inactive Phospholipase C-Like Protein 2 3
  • Phospholipase C, Epsilon 2 2
  • Phospholipase C-Like 2 2
  • EC 61
  • KIAA1092 4

External Ids for PLCL2 Gene

Previous HGNC Symbols for PLCL2 Gene

  • PLCE2

Previous GeneCards Identifiers for PLCL2 Gene

  • GC03P016855

Summaries for PLCL2 Gene

GeneCards Summary for PLCL2 Gene

PLCL2 (Phospholipase C Like 2) is a Protein Coding gene. Among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCL1.

UniProtKB/Swiss-Prot for PLCL2 Gene

  • May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCL2 Gene

Genomics for PLCL2 Gene

Regulatory Elements for PLCL2 Gene

Enhancers for PLCL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F016840 1 FANTOM5 Ensembl ENCODE 21.3 +41.5 41451 6.6 SIN3A YY1 ZNF121 GLIS2 ZNF143 ZNF207 ZNF263 ZNF202 JUNB TBX21 PLCL2 ENSG00000271964 RFTN1 LOC105376972 MIR3714
GH03F016823 0.8 Ensembl ENCODE 18.8 +21.7 21732 1.2 IKZF1 PLCL2 MIR3714 LOC105376972
GH03F016848 1 FANTOM5 Ensembl ENCODE 16.9 +46.8 46750 2.8 SCRT1 RFX1 JUN JUNB BMI1 ZIC2 ZNF664 SMARCA4 SCRT2 EED PLCL2 LOC105376972 MIR3714
GH03F016828 1 Ensembl ENCODE 16.7 +26.4 26350 0.4 CTCF ZNF654 ESRRA SMC3 TRIM22 ZNF384 RAD21 PLCL2 MIR3714 LOC105376972
GH03F016869 0.9 Ensembl 13.1 +67.3 67250 0.2 WT1 PLCL2 LOC105376972 MIR3714
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PLCL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCL2 Gene

16,802,651 bp from pter
17,090,606 bp from pter
287,956 bases
Plus strand

Genomic View for PLCL2 Gene

Genes around PLCL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCL2 Gene

Proteins for PLCL2 Gene

  • Protein details for PLCL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive phospholipase C-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K5V4
    • Q8N498
    • Q9H8L0
    • Q9UFP9

    Protein attributes for PLCL2 Gene

    1127 amino acids
    Molecular mass:
    125866 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA83044.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14606.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLCL2 Gene


neXtProt entry for PLCL2 Gene

Selected DME Specific Peptides for PLCL2 Gene


Post-translational modifications for PLCL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PLCL2 Gene

Gene Families for PLCL2 Gene

Suggested Antigen Peptide Sequences for PLCL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
  • Contains 1 PH domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCL2: view

Function for PLCL2 Gene

Molecular function for PLCL2 Gene

UniProtKB/Swiss-Prot Function:
May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for PLCL2 Gene

Gene Ontology (GO) - Molecular Function for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0050811 GABA receptor binding IDA 16754670
genes like me logo Genes that share ontologies with PLCL2: view
genes like me logo Genes that share phenotypes with PLCL2: view

Animal Models for PLCL2 Gene

MGI Knock Outs for PLCL2:

Animal Model Products

miRNA for PLCL2 Gene

miRTarBase miRNAs that target PLCL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLCL2 Gene

Localization for PLCL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCL2 Gene

Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PLCL2 Gene COMPARTMENTS Subcellular localization image for PLCL2 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PLCL2: view

Pathways & Interactions for PLCL2 Gene

genes like me logo Genes that share pathways with PLCL2: view

Pathways by source for PLCL2 Gene

1 GeneTex pathway for PLCL2 Gene
1 PharmGKB pathway for PLCL2 Gene

Interacting Proteins for PLCL2 Gene

Gene Ontology (GO) - Biological Process for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002322 B cell proliferation involved in immune response IEA --
GO:0002337 B-1a B cell differentiation IEA --
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007214 gamma-aminobutyric acid signaling pathway IEA --
genes like me logo Genes that share ontologies with PLCL2: view

No data available for SIGNOR curated interactions for PLCL2 Gene

Transcripts for PLCL2 Gene

Unigene Clusters for PLCL2 Gene

Phospholipase C-like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCL2 Gene

No ASD Table

Relevant External Links for PLCL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLCL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLCL2 Gene

Protein differential expression in normal tissues from HIPED for PLCL2 Gene

This gene is overexpressed in Frontal cortex (9.0), Heart (7.2), Pancreatic juice (6.8), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLCL2 Gene

Protein tissue co-expression partners for PLCL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLCL2 Gene:


SOURCE GeneReport for Unigene cluster for PLCL2 Gene:

genes like me logo Genes that share expression patterns with PLCL2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLCL2 Gene

Orthologs for PLCL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLCL2 34 35
  • 99.62 (n)
(Ornithorhynchus anatinus)
Mammalia PLCL2 35
  • 93 (a)
(Canis familiaris)
Mammalia PLCL2 34 35
  • 92.43 (n)
(Rattus norvegicus)
Mammalia Plcl2 34
  • 90.38 (n)
(Mus musculus)
Mammalia Plcl2 34 16 35
  • 89.05 (n)
(Bos Taurus)
Mammalia PLCL2 34 35
  • 84.44 (n)
(Monodelphis domestica)
Mammalia PLCL2 35
  • 84 (a)
(Gallus gallus)
Aves PLCL2 34 35
  • 80.96 (n)
(Anolis carolinensis)
Reptilia PLCL2 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plcl2 34
  • 77.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12143 34
(Danio rerio)
Actinopterygii PLCL2 35
  • 73 (a)
plcl2 34
  • 71.93 (n)
(Caenorhabditis elegans)
Secernentea pll-1 34 35
  • 49.38 (n)
plc-4 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
Species where no ortholog for PLCL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCL2 Gene

Gene Tree for PLCL2 (if available)
Gene Tree for PLCL2 (if available)

Paralogs for PLCL2 Gene

Paralogs for PLCL2 Gene

(10) SIMAP similar genes for PLCL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLCL2: view

Variants for PLCL2 Gene

Sequence variations from dbSNP and Humsavar for PLCL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10084658 -- 17,022,984(+) TCCCC(C/T)TCTTC intron-variant
rs1025818 -- 16,923,529(-) AAAGA(A/G)TAGAA intron-variant
rs1031300 -- 16,837,707(+) TTATA(A/G)ATGAG intron-variant
rs1036732 -- 16,907,377(+) TTGTG(A/T)GCACA intron-variant
rs1036733 -- 16,878,330(+) ACAAA(C/T)GCCAA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCL2 Gene

Variant ID Type Subtype PubMed ID
dgv289e215 CNV deletion 23714750
esv2424217 CNV insertion 19546169
esv2675677 CNV deletion 23128226
esv2676563 CNV deletion 23128226
esv3400051 CNV duplication 20981092
esv3595410 CNV loss 21293372
esv3595411 CNV loss 21293372
nsv1127943 CNV deletion 24896259
nsv477499 CNV novel sequence insertion 20440878
nsv819815 CNV loss 19587683
nsv955321 CNV duplication 24416366

Variation tolerance for PLCL2 Gene

Residual Variation Intolerance Score: 3.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLCL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCL2 Gene

Disorders for PLCL2 Gene

Relevant External Links for PLCL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLCL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCL2 Gene

Publications for PLCL2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells G.F. … Anderson C.A. (Nat. Genet. 2011) 3 46 64
  3. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PMID: 19898481) Raychaudhuri S. … Plenge R.M. (Nat. Genet. 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Identification and characterization of a new phospholipase C-like protein, PLC-L(2). (PMID: 10581172) Otsuki M. … Takenawa T. (Biochem. Biophys. Res. Commun. 1999) 3 22 64

Products for PLCL2 Gene

Sources for PLCL2 Gene

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