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Aliases for PLCL2 Gene

Aliases for PLCL2 Gene

  • Phospholipase C-Like 2 2 3
  • Phospholipase C, Epsilon 2 2 3
  • Phospholipase C-Epsilon-2 3 4
  • Phospholipase C-L2 3 4
  • PLC-Epsilon-2 3 4
  • PLC-L(2) 3 4
  • KIAA1092 4 6
  • PLC-L2 3 4
  • PLCE2 3 4
  • Inactive Phospholipase C-Like Protein 2 3
  • EC 63

External Ids for PLCL2 Gene

Previous HGNC Symbols for PLCL2 Gene

  • PLCE2

Previous GeneCards Identifiers for PLCL2 Gene

  • GC03P016855

Summaries for PLCL2 Gene

GeneCards Summary for PLCL2 Gene

PLCL2 (Phospholipase C-Like 2) is a Protein Coding gene. Among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics. GO annotations related to this gene include calcium ion binding and signal transducer activity. An important paralog of this gene is PLCH1.

UniProtKB/Swiss-Prot for PLCL2 Gene

  • May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCL2 Gene

Genomics for PLCL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLCL2 Gene

16,802,651 bp from pter
17,090,606 bp from pter
287,956 bases
Plus strand

Genomic View for PLCL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCL2 Gene

Proteins for PLCL2 Gene

  • Protein details for PLCL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive phospholipase C-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K5V4
    • Q8N498
    • Q9H8L0
    • Q9UFP9

    Protein attributes for PLCL2 Gene

    1127 amino acids
    Molecular mass:
    125866 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA83044.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14606.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLCL2 Gene


neXtProt entry for PLCL2 Gene

Proteomics data for PLCL2 Gene at MOPED

Selected DME Specific Peptides for PLCL2 Gene

Post-translational modifications for PLCL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCL2 Gene

Antibody Products

Domains for PLCL2 Gene

Gene Families for PLCL2 Gene

Suggested Antigen Peptide Sequences for PLCL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
  • Contains 1 PH domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCL2: view

Function for PLCL2 Gene

Molecular function for PLCL2 Gene

UniProtKB/Swiss-Prot Function:
May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for PLCL2 Gene

Gene Ontology (GO) - Molecular Function for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding --
GO:0005515 protein binding --
GO:0008081 phosphoric diester hydrolase activity --
genes like me logo Genes that share ontologies with PLCL2: view

Phenotypes for PLCL2 Gene

genes like me logo Genes that share phenotypes with PLCL2: view

Animal Models for PLCL2 Gene

MGI Knock Outs for PLCL2:

Animal Model Products

miRNA for PLCL2 Gene

miRTarBase miRNAs that target PLCL2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLCL2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PLCL2 Gene

Localization for PLCL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCL2 Gene

Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PLCL2 Gene COMPARTMENTS Subcellular localization image for PLCL2 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PLCL2: view

Pathways for PLCL2 Gene

genes like me logo Genes that share pathways with PLCL2: view

Pathways by source for PLCL2 Gene

1 PharmGKB pathway for PLCL2 Gene

Interacting Proteins for PLCL2 Gene

Selected Interacting proteins: Q9UPR0-PLCL2_HUMAN for PLCL2 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002322 B cell proliferation involved in immune response IEA --
GO:0002337 B-1a B cell differentiation IEA --
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction --
GO:0007214 gamma-aminobutyric acid signaling pathway IEA --
genes like me logo Genes that share ontologies with PLCL2: view

Transcripts for PLCL2 Gene

Unigene Clusters for PLCL2 Gene

Phospholipase C-like 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLCL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCL2 Gene

No ASD Table

Relevant External Links for PLCL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLCL2 Gene

mRNA expression in normal human tissues for PLCL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PLCL2 Gene

This gene is overexpressed in Frontal cortex (9.0), Heart (7.2), Pancreatic juice (6.8), and Lymph node (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PLCL2 Gene

SOURCE GeneReport for Unigene cluster for PLCL2 Gene Hs.741267

genes like me logo Genes that share expressions with PLCL2: view

Expression partners for PLCL2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLCL2 Gene

Orthologs for PLCL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLCL2 35
  • 84.44 (n)
  • 95.08 (a)
PLCL2 36
  • 88 (a)
(Canis familiaris)
Mammalia PLCL2 35
  • 92.43 (n)
  • 97.43 (a)
PLCL2 36
  • 99 (a)
(Mus musculus)
Mammalia Plcl2 35
  • 89.05 (n)
  • 96.63 (a)
Plcl2 16
Plcl2 36
  • 87 (a)
(Pan troglodytes)
Mammalia PLCL2 35
  • 99.62 (n)
  • 100 (a)
PLCL2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Plcl2 35
  • 90.38 (n)
  • 97.7 (a)
(Monodelphis domestica)
Mammalia PLCL2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia PLCL2 36
  • 93 (a)
(Gallus gallus)
Aves PLCL2 35
  • 80.96 (n)
  • 88.76 (a)
PLCL2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia PLCL2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plcl2 35
  • 77.23 (n)
  • 85.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12143 35
(Danio rerio)
Actinopterygii plcl2 35
  • 71.93 (n)
  • 79.36 (a)
PLCL2 36
  • 73 (a)
(Caenorhabditis elegans)
Secernentea pll-1 35
  • 49.38 (n)
  • 43.36 (a)
plc-4 36
  • 32 (a)
pll-1 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for PLCL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCL2 Gene

Gene Tree for PLCL2 (if available)
Gene Tree for PLCL2 (if available)

Paralogs for PLCL2 Gene

Paralogs for PLCL2 Gene

(10) SIMAP similar genes for PLCL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLCL2: view

Variants for PLCL2 Gene

Sequence variations from dbSNP and Humsavar for PLCL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8895 -- 17,090,414(-) GACCC(C/T)GGGGA utr-variant-3-prime
rs894098 -- 16,883,554(+) CTGTA(A/G)CGCTG upstream-variant-2KB
rs964576 -- 16,960,613(+) TTCAC(C/T)CCATT intron-variant
rs977477 -- 16,906,609(+) GTATT(C/T)GCAAT intron-variant
rs983545 -- 16,918,160(-) TCTTA(C/T)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCL2 Gene

Variant ID Type Subtype PubMed ID
esv2675677 CNV Deletion 23128226
esv2676563 CNV Deletion 23128226
esv2424217 CNV Insertion 19546169
nsv819815 CNV Loss 19587683

Relevant External Links for PLCL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCL2 Gene

Disorders for PLCL2 Gene

Relevant External Links for PLCL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PLCL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PLCL2 Gene

Publications for PLCL2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification and characterization of a new phospholipase C-like protein, PLC-L(2). (PMID: 10581172) Otsuki M. … Takenawa T. (Biochem. Biophys. Res. Commun. 1999) 3 23
  4. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PMID: 19898481) Raychaudhuri S. … Plenge R.M. (Nat. Genet. 2009) 3 48
  5. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells G.F. … Anderson C.A. (Nat. Genet. 2011) 3 48

Products for PLCL2 Gene

Sources for PLCL2 Gene

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