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PLCL2 Gene

protein-coding   GIFtS: 57
GCID: GC03P016901

Phospholipase C-Like 2

(Previous names: phospholipase C, epsilon 2)
(Previous symbol: PLCE2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase C-Like 21 2     PLC-L22 3
PLCE21 2 3     PLC-epsilon-22 3
Phospholipase C, Epsilon 21 2     KIAA10923 5
Phospholipase C-Epsilon-22 3     Inactive Phospholipase C-Like Protein 22
Phospholipase C-L22 3     EC 3.1.4.118
PLC-L(2)2 3     

External Ids:    HGNC: 90641   Entrez Gene: 232282   Ensembl: ENSG000001548227   OMIM: 6142765   UniProtKB: Q9UPR03   

Export aliases for PLCL2 gene to outside databases

Previous GC identifer: GC03P016855


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLCL2 Gene:
PLCL2 (phospholipase C-like 2) is a protein-coding gene. GO annotations related to this gene include signal transducer activity and calcium ion binding. An important paralog of this gene is PLCD4.

UniProtKB/Swiss-Prot: PLCL2_HUMAN, Q9UPR0
Function: May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PLCL2 gene promoter:
         C/EBPbeta   Nkx2-2   POU6F1 (c2)   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   HNF-3beta   Evi-1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCL2 promoter sequence
   Search Chromatin IP Primers for PLCL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p25.3-p25.1

PLCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCL2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P016901:  view genomic region     (about GC identifiers)

Start:
16,844,159 bp from pter      End:
17,132,098 bp from pter
Size:
287,940 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLCL2_HUMAN, Q9UPR0 (See protein sequence)
Recommended Name: Inactive phospholipase C-like protein 2  
Size: 1127 amino acids; 125866 Da
Caution: In the PI-PLC X-box Thr-486 is present instead of the conserved His which is one of the active site
residues. It is therefore expected that this protein lacks catalytic activity
Sequence caution: Sequence=BAA83044.1; Type=Erroneous initiation; Sequence=BAB14606.1; Type=Erroneous initiation;
Secondary accessions: A8K5V4 Q8N498 Q9H8L0 Q9UFP9
Alternative splicing: 3 isoforms:  Q9UPR0-1   Q9UPR0-2   Q9UPR0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLCL2: NX_Q9UPR0

Explore proteomics data for PLCL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for PLCL2 (Q9UPR0)
     SSHNTYL  PLSHYFI 


    See PLCL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137854.1  NP_055999.2  

    ENSEMBL proteins: 
     ENSP00000409637   ENSP00000412836   ENSP00000404433   ENSP00000379979  

    PLCL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for PLCL2
    OriGene Protein Over-expression Lysate for PLCL2
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    Novus Biologicals PLCL2 Proteins
    Novus Biologicals PLCL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLCL2

     
    Search eBioscience for Proteins for PLCL2 

     
    antibodies-online proteins for PLCL2 (4 products) 

     
    antibodies-online peptides for PLCL2

    PLCL2 Antibody Products:

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    Abcam antibodies for PLCL2
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    ThermoFisher Antibodies for PLCL2
    antibodies-online antibodies for PLCL2 (17 products) 

    PLCL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PLCL2
    Cloud-Clone Corp. CLIAs for PLCL2
    Search eBioscience for ELISAs for PLCL2 
    antibodies-online kits for PLCL2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-dom_pair
     IPR001192 PI-PLC_fam
     IPR028383 PLCL2
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q9UPR0

    ProtoNet protein and cluster: Q9UPR0

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PLCL2_HUMAN, Q9UPR0
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain


    Find genes that share domains with PLCL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCL2_HUMAN, Q9UPR0
    Function: May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum (By similarity)

         Enzyme Number (IUBMB): EC 3.1.4.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0008081phosphoric diester hydrolase activity ----
         
    Find genes that share ontologies with PLCL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PLCL2:
     Decreased Wnt reporter activit 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plcl2):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with PLCL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Plcl2tm1Tta for PLCL2

       genOway: Develop your customized and physiologically relevant rodent model for PLCL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLCL2:
    hsa-mir-181a-5p (MIRT025184)

    Block miRNA regulation of human, mouse, rat PLCL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLCL2 (see all 28):
    hsa-miR-181c hsa-miR-513a-5p hsa-miR-128 hsa-miR-301a hsa-miR-221 hsa-miR-218 hsa-miR-330-3p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidPLCL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLCL2
    Predesigned siRNA for gene silencing in human, mouse, rat PLCL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLCL2

    Clone
    Products:
         
    OriGene clones in human, mouse for PLCL2 (see all 11)
    OriGene ORF clones in mouse, rat for PLCL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLCL2 (NM_015184)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCL2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PLCL2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLCL2_HUMAN, Q9UPR0: Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube
    C2C12 cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with PLCL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLCL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Proton Pump Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics


    1 PharmGKB Pathway for PLCL2
        Proton Pump Inhibitor Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLCL2
    Interactions:

        Search GeneGlobe Interaction Network for PLCL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLCL2 (Q9UPR02, 3 ENSP000004096374) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621362, 3MINT-62200 I2D: score=3 
    DSCAML1Q8TD843, ENSP000003154654I2D: score=3 STRING: ENSP00000315465
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    CCNCENSP000003582224STRING: ENSP00000358222
    MTORENSP000003545584STRING: ENSP00000354558
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process IEA--
    GO:0007165signal transduction ----
    GO:0035556intracellular signal transduction IEA--

    Find genes that share ontologies with PLCL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLCL2

    Selected HMDB Compounds for PLCL2 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLCL2 gene (2 alternative transcripts): 
    NM_001144382.1  NM_015184.5  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460467(uc010het.1) ENST00000418129(uc011awc.2) ENST00000432376(uc011awd.2)
    ENST00000419842 ENST00000396755
    miRNA
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    Block miRNA regulation of human, mouse, rat PLCL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLCL2 (see all 28):
    hsa-miR-181c hsa-miR-513a-5p hsa-miR-128 hsa-miR-301a hsa-miR-221 hsa-miR-218 hsa-miR-330-3p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidPLCL2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLCL2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLCL2 (NM_015184)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCL2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PLCL2
    OriGene qSTAR qPCR primer pairs in human, mouse for PLCL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCL2
      QuantiTect SYBR Green Assays in human, mouse, rat PLCL2
      QuantiFast Probe-based Assays in human, mouse, rat PLCL2

    Selected AceView cDNA sequences (see all 82):

    AI824936 AK125854 AU136265 CR601279 AI167717 AA677432 AL117515 BP379000 
    AA766113 AA236094 AW500653 W21387 F23263 BP364770 AA748606 CB134591 
    AI633685 BE220932 BP343381 AI953642 BC036392 AI248377 AI632741 CD103486 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLCL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAGAGATG
    PLCL2 Expression
    About this image


    PLCL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
    PLCL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLCL2 Protein Expression
        Custom PCR Arrays for PLCL2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLCL2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcl21 , 5 phospholipase C-like 21, 5 89.05(n)1
    96.63(a)1
      17 (25.86 cM)5
    2248601  NM_013880.31  NP_038908.21 
     505095475 
    chicken
    (Gallus gallus)
    Aves PLCL21 phospholipase C-like 2 80.96(n)
    88.76(a)
      420645  XM_418744.4  XP_418744.3 
    lizard
    (Anolis carolinensis)
    Reptilia PLCL26
    phospholipase C-like 2
    81(a)
    1 ↔ 1
    6(34681018-34783485)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.121432 Xenopus laevis transcribed sequence with moderate similarity more 75.22(n)    BJ074920.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plcl21 phospholipase C-like 2 71.93(n)
    79.36(a)
      100334276  XM_002667679.2  XP_002667725.2 
    worm
    (Caenorhabditis elegans)
    Secernentea pll-11 pll-1 49.38(n)
    43.36(a)
      187273  NM_171059.4  NP_741067.1 


    ENSEMBL Gene Tree for PLCL2 (if available)
    TreeFam Gene Tree for PLCL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLCL2 gene
    PLCD42  PLCD12  PLCB22  PLCZ12  PLCH12  PLCB32  PLCD32  PLCH22  
    PLCB12  PLCB42  PLCL12  
    10 SIMAP similar genes for PLCL2 using alignment to 2 protein entries:     PLCL2_HUMAN (see all proteins):
    PLCL1    DKFZp686K101    PLCD1    PLCZ1    PLCD3    PLCD4
    FLJ00414    PLCH2    PLCB1    PLCB4

    Find genes that share paralogs with PLCL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLCL2 (see all 3806)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774169481,2
    Cuntested116987360(+) AACAGA/GAAAAA 2 E G mis10--------
    rs1466582521,2
    --16860447(+) CCCAGG/TTTGGA 1 -- us2k10--------
    rs1864001041,2
    --16860556(+) AGTATA/GTATAT 1 -- us2k10--------
    rs22520861,2
    C,F,A,H--16860581(+) TTCCTT/CAGAGG 1 -- us2k122Minor allele frequency- C:0.21EA NS NA WA 3842
    rs1402527051,2
    --16860645(+) CACCCC/GGCCTC 1 -- us2k10--------
    rs1916083421,2
    --16860714(+) CACGAA/GTTGGG 1 -- us2k10--------
    rs1147470871,2
    C,F--16860830(+) GGGGTC/TTCACC 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs64426531,2
    C,F,A,H--16860864(+) GGCTCC/TAGGGA 1 -- us2k110Minor allele frequency- T:0.10NS EA WA NA 1000
    rs1144869631,2
    F--16860879(+) GATCCA/GGGGGA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1452604361,2
    --16860916(+) TCAGCC/TTGGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLCL2 (16844159 - 17094159 bp, first 250kb of PLCL2)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PLCL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675677CNV Deletion23128226
    esv2676563CNV Deletion23128226
    esv2424217CNV Insertion19546169
    nsv819815CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614276    OMIM disorders: --


    Find genes that share disorders with PLCL2           About GenesLikeMe

    Genetic Association Database (GAD): PLCL2
    Human Genome Epidemiology (HuGE) Navigator: PLCL2 (1 document)

    Export disorders for PLCL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLCL2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with PLCL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R.... Ohara O. (DNA Res. 1999)
    2. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1, 4 Mells G.F....Anderson C.A. (Nat. Genet. 2011)
    3. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Identification and characterization of a new phospholipase C-like protein, PLC-L(2). (PubMed id 10581172)1, 9 Otsuki M....Takenawa T. (Biochem. Biophys. Res. Commun. 1999)
    6. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (Nature 2011)
    7. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (Nat. Genet. 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23228 HGNC: 9064 AceView: PLCL2 Ensembl:ENSG00000154822 euGenes: HUgn23228
    ECgene: PLCL2 H-InvDB: PLCL2

    (According to HUGE)
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    HUGE: KIAA1092

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLCL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLCL2 gene:
    Search GeneIP for patents involving PLCL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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