Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLCL2 Gene

Aliases for PLCL2 Gene

  • Phospholipase C Like 2 2 3 5
  • Phospholipase C, Epsilon 2 2 3
  • Phospholipase C-Epsilon-2 3 4
  • Phospholipase C-Like 2 2 3
  • Phospholipase C-L2 3 4
  • PLC-Epsilon-2 3 4
  • PLC-L(2) 3 4
  • PLC-L2 3 4
  • PLCE2 3 4
  • EC 63
  • KIAA1092 4

External Ids for PLCL2 Gene

Previous HGNC Symbols for PLCL2 Gene

  • PLCE2

Previous GeneCards Identifiers for PLCL2 Gene

  • GC03P016855

Summaries for PLCL2 Gene

GeneCards Summary for PLCL2 Gene

PLCL2 (Phospholipase C Like 2) is a Protein Coding gene. Among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCB3.

UniProtKB/Swiss-Prot for PLCL2 Gene

  • May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCL2 Gene

Genomics for PLCL2 Gene

Regulatory Elements for PLCL2 Gene

Enhancers for PLCL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLCL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCL2 Gene

16,802,651 bp from pter
17,090,606 bp from pter
287,956 bases
Plus strand

Genomic View for PLCL2 Gene

Genes around PLCL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCL2 Gene

Proteins for PLCL2 Gene

  • Protein details for PLCL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive phospholipase C-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K5V4
    • Q8N498
    • Q9H8L0
    • Q9UFP9

    Protein attributes for PLCL2 Gene

    1127 amino acids
    Molecular mass:
    125866 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA83044.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14606.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLCL2 Gene


neXtProt entry for PLCL2 Gene

Proteomics data for PLCL2 Gene at MOPED

Selected DME Specific Peptides for PLCL2 Gene

Post-translational modifications for PLCL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCL2 Gene

Domains & Families for PLCL2 Gene

Gene Families for PLCL2 Gene

Suggested Antigen Peptide Sequences for PLCL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
  • Contains 1 PH domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCL2: view

Function for PLCL2 Gene

Molecular function for PLCL2 Gene

UniProtKB/Swiss-Prot Function:
May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for PLCL2 Gene

Gene Ontology (GO) - Molecular Function for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050811 GABA receptor binding IDA 16754670
genes like me logo Genes that share ontologies with PLCL2: view
genes like me logo Genes that share phenotypes with PLCL2: view

Animal Models for PLCL2 Gene

MGI Knock Outs for PLCL2:

Animal Model Products

miRNA for PLCL2 Gene

miRTarBase miRNAs that target PLCL2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLCL2 Gene

Localization for PLCL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCL2 Gene

Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PLCL2 Gene COMPARTMENTS Subcellular localization image for PLCL2 gene
Compartment Confidence
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for PLCL2 Gene

Pathways & Interactions for PLCL2 Gene

genes like me logo Genes that share pathways with PLCL2: view

Pathways by source for PLCL2 Gene

1 GeneTex pathway for PLCL2 Gene
1 PharmGKB pathway for PLCL2 Gene

Interacting Proteins for PLCL2 Gene

Selected Interacting proteins: Q9UPR0-PLCL2_HUMAN for PLCL2 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002337 B-1a B cell differentiation IEA --
GO:0007165 signal transduction IEA --
GO:0016042 lipid catabolic process IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0050859 negative regulation of B cell receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PLCL2: view

No data available for SIGNOR curated interactions for PLCL2 Gene

Drugs & Compounds for PLCL2 Gene

No Compound Related Data Available

Transcripts for PLCL2 Gene

Unigene Clusters for PLCL2 Gene

Phospholipase C-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCL2 Gene

No ASD Table

Relevant External Links for PLCL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLCL2 Gene

mRNA expression in normal human tissues for PLCL2 Gene

Protein differential expression in normal tissues from HIPED for PLCL2 Gene

This gene is overexpressed in Frontal cortex (9.0), Heart (7.2), Pancreatic juice (6.8), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PLCL2 Gene

SOURCE GeneReport for Unigene cluster for PLCL2 Gene Hs.741267

genes like me logo Genes that share expression patterns with PLCL2: view

Protein tissue co-expression partners for PLCL2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLCL2 Gene

Orthologs for PLCL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLCL2 35
  • 84.44 (n)
  • 95.08 (a)
PLCL2 36
  • 88 (a)
(Canis familiaris)
Mammalia PLCL2 35
  • 92.43 (n)
  • 97.43 (a)
PLCL2 36
  • 99 (a)
(Mus musculus)
Mammalia Plcl2 35
  • 89.05 (n)
  • 96.63 (a)
Plcl2 16
Plcl2 36
  • 87 (a)
(Pan troglodytes)
Mammalia PLCL2 35
  • 99.62 (n)
  • 100 (a)
PLCL2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Plcl2 35
  • 90.38 (n)
  • 97.7 (a)
(Monodelphis domestica)
Mammalia PLCL2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia PLCL2 36
  • 93 (a)
(Gallus gallus)
Aves PLCL2 35
  • 80.96 (n)
  • 88.76 (a)
PLCL2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia PLCL2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plcl2 35
  • 77.23 (n)
  • 85.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12143 35
(Danio rerio)
Actinopterygii plcl2 35
  • 71.93 (n)
  • 79.36 (a)
PLCL2 36
  • 73 (a)
(Caenorhabditis elegans)
Secernentea pll-1 35
  • 49.38 (n)
  • 43.36 (a)
plc-4 36
  • 32 (a)
pll-1 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for PLCL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCL2 Gene

Gene Tree for PLCL2 (if available)
Gene Tree for PLCL2 (if available)

Paralogs for PLCL2 Gene

Paralogs for PLCL2 Gene

(10) SIMAP similar genes for PLCL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLCL2: view

Variants for PLCL2 Gene

Sequence variations from dbSNP and Humsavar for PLCL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17853614 - 17,009,978(+) TGACC(A/G)GATAT reference, missense
rs17857109 - 17,011,249(+) TTCAG(A/G/T)TGTCG reference, missense
rs17857110 - 17,011,571(+) CAGCG(C/T)CAATA reference, missense
rs17853612 - 17,011,772(+) CGCTC(A/C)CATTT reference, missense
rs17853613 - 17,012,015(+) GCCTC(A/G)TAAAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLCL2 Gene

Variant ID Type Subtype PubMed ID
esv2675677 CNV Deletion 23128226
esv2676563 CNV Deletion 23128226
esv2424217 CNV Insertion 19546169
nsv819815 CNV Loss 19587683

Variation tolerance for PLCL2 Gene

Residual Variation Intolerance Score: 3.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLCL2 Gene

Disorders for PLCL2 Gene

Relevant External Links for PLCL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLCL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCL2 Gene

Publications for PLCL2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Identification and characterization of a new phospholipase C-like protein, PLC-L(2). (PMID: 10581172) Otsuki M. … Takenawa T. (Biochem. Biophys. Res. Commun. 1999) 3 23
  3. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. (PMID: 24916648) Hirokawa M. … Kubo M. (Eur. J. Hum. Genet. 2015) 3
  4. Identification of NF-I_B and PLCL2 as new susceptibility genes and highlights on a potential role of IRF8 through interferon signature modulation in systemic sclerosis. (PMID: 25880423) Arismendi M. … Allanore Y. (Arthritis Res. Ther. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PLCL2 Gene

Sources for PLCL2 Gene