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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLCL2 Gene

protein-coding   GIFtS: 60
GCID: GC03P016901

Phospholipase C-Like 2

(Previous names: phospholipase C, epsilon 2)
(Previous symbol: PLCE2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase C-Like 21 2     PLC-L22 3
PLCE21 2 3     PLC-epsilon-22 3
Phospholipase C, Epsilon 21 2     Inactive Phospholipase C-Like Protein 22
Phospholipase C-Epsilon-22 3     KIAA10923
Phospholipase C-L22 3     EC 3.1.4.118
PLC-L(2)2 3     

External Ids:    HGNC: 90641   Entrez Gene: 232282   Ensembl: ENSG000001548227   OMIM: 6142765   UniProtKB: Q9UPR03   

Export aliases for PLCL2 gene to outside databases

Previous GC identifer: GC03P016855


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PLCL2 Gene: 
PLCL2 (phospholipase C-like 2) is a protein-coding gene. Diseases associated with PLCL2 include primary biliary cirrhosis, and multiple sclerosis. GO annotations related to this gene include signal transducer activity and calcium ion binding. An important paralog of this gene is PLCD4.

UniProtKB/Swiss-Prot: PLCL2_HUMAN, Q9UPR0
Function: May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLCL2 gene promoter:
         C/EBPbeta   Nkx2-2   POU6F1 (c2)   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   HNF-3beta   Evi-1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLCL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p25.3-p25.1

PLCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCL2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P016901:  view genomic region     (about GC identifiers)

Start:
16,844,159 bp from pter      End:
17,132,098 bp from pter
Size:
287,940 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLCL2_HUMAN, Q9UPR0 (See protein sequence)
Recommended Name: Inactive phospholipase C-like protein 2  
Size: 1127 amino acids; 125866 Da
Subcellular location: Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube
C2C12 cells (By similarity)
Caution: In the PI-PLC X-box Thr-486 is present instead of the conserved His which is one of the active site
residues. It is therefore expected that this protein lacks catalytic activity
Sequence caution: Sequence=BAA83044.1; Type=Erroneous initiation; Sequence=BAB14606.1; Type=Erroneous initiation;
Secondary accessions: A8K5V4 Q8N498 Q9H8L0 Q9UFP9
Alternative splicing: 3 isoforms:  Q9UPR0-1   Q9UPR0-2   Q9UPR0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLCL2: NX_Q9UPR0

Explore proteomics data for PLCL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPR0

  • 2 DME Specific Peptides for PLCL2 (Q9UPR0)
     SSHNTYL  PLSHYFI 

    PLCL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLCL2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137854.1  NP_055999.2  

    ENSEMBL proteins: 
     ENSP00000409637   ENSP00000412836   ENSP00000404433   ENSP00000379979  

    Human Recombinant Protein Products for PLCL2: 
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    OriGene Purified Protein for PLCL2
    OriGene Protein Over-expression Lysate for PLCL2
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    Novus Biologicals PLCL2 Proteins
    Novus Biologicals PLCL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLCL2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    PLCL2 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for PLCL2 

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    Cloud-Clone Corp. ELISAs for PLCL2 
    Cloud-Clone Corp. CLIAs for PLCL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/11 InterPro protein domains (see all 11):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-like_dom
     IPR001192 Pinositol_PLipase_C
     IPR001849 Pleckstrin_homology
     IPR018029 C2_membr_targeting

    Graphical View of Domain Structure for InterPro Entry Q9UPR0

    ProtoNet protein and cluster: Q9UPR0

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PLCL2_HUMAN, Q9UPR0
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain


    PLCL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCL2_HUMAN, Q9UPR0
    Function: May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum (By similarity)

         Enzyme Number (IUBMB): EC 3.1.4.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    PLCL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PLCL2:
     Decreased Wnt reporter activit 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plcl2):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    PLCL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Plcl2tm1Tta for PLCL2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLCL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLCL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLCL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLCL2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCL2
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCL2 (see all 28):
    hsa-miR-181c hsa-miR-513a-5p hsa-miR-128 hsa-miR-301a hsa-miR-221 hsa-miR-218 hsa-miR-330-3p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidPLCL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLCL2
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLCL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Proton Pump Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics


    1 PharmGKB Pathway for PLCL2
        Proton Pump Inhibitor Pathway, Pharmacodynamics

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLCL2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for PLCL2 (Q9UPR02, 3 ENSP000004096374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621362, 3MINT-62200 I2D: score=3 
    DSCAML1Q8TD843, ENSP000003154654I2D: score=3 STRING: ENSP00000315465
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process IEA--
    GO:0007165signal transduction ----
    GO:0035556intracellular signal transduction IEA--

    PLCL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PLCL2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLCL2

    10/843 HMDB Compounds for PLCL2 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----

    Search CenterWatch for drugs/clinical trials and news about PLCL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLCL2 gene (2 alternative transcripts): 
    NM_001144382.1  NM_015184.5  

    Unigene Cluster for PLCL2:

    Phospholipase C-like 2
    Hs.741267  [show with all ESTs]
    Unigene Representative Sequence: NM_001144382
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460467(uc010het.1) ENST00000418129(uc011awc.2) ENST00000432376(uc011awd.2)
    ENST00000419842 ENST00000396755
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCL2
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCL2 (see all 28):
    hsa-miR-181c hsa-miR-513a-5p hsa-miR-128 hsa-miR-301a hsa-miR-221 hsa-miR-218 hsa-miR-330-3p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidPLCL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLCL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCL2
    Clone
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    OriGene clones in human, mouse for PLCL2 (see all 11)
    OriGene ORF clones in mouse, rat for PLCL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLCL2 (NM_015184)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCL2
    Sirion Biotech Customized lentivirus for stable overexpression of PLCL2 
                         Customized lentivirus expression plasmids for stable overexpression of PLCL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PLCL2
    OriGene qSTAR qPCR primer pairs in human, mouse for PLCL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLCL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLCL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCL2

    Additional mRNA sequence: 

    AB029015.1 AK023546.1 AK125854.1 AK291419.1 AL117515.1 BC036392.2 

    6 DOTS entries:

    DT.211488  DT.100009199  DT.91800744  DT.65286166  DT.40194930  DT.40299314 

    24/82 AceView cDNA sequences (see all 82):

    AW500653 AI167717 AI633685 BP379000 AU136265 AK125854 AA236094 BP364770 
    BP343381 BE220932 AA766113 CB134591 CR601279 AL117515 F23263 W21387 
    AA748606 AA677432 AI824936 AK023546 BQ004926 BF793905 AL526158 AA805400 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLCL2 expression in normal human tissues (normalized intensities)      PLCL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAGAGATG
    PLCL2 Expression
    About this image


    PLCL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Superior Cervical Ganglion   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             Retina

    See PLCL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLCL2

    SOURCE GeneReport for Unigene cluster: Hs.741267
        SABiosciences Custom PCR Arrays for PLCL2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PLCL2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcl21 , 5 phospholipase C-like 21, 5 89.19(n)1
    96.89(a)1
      17 (25.86 cM)5
    2248601  NM_013880.31  NP_038908.21 
     505095475 
    chicken
    (Gallus gallus)
    Aves PLCL21 phospholipase C-like 2 80.97(n)
    88.6(a)
      420645  XM_418744.3  XP_418744.3 
    lizard
    (Anolis carolinensis)
    Reptilia PLCL26
    phospholipase C-like 2
    81(a)
    1 ↔ 1
    6(34681018-34783485)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.121432 Xenopus laevis transcribed sequence with moderate similarity more 75.22(n)    BJ074920.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plcl21 phospholipase C-like 2 71.51(n)
    78.86(a)
      100334276  XM_002667679.1  XP_002667725.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pll-11 Protein PLL-1 49.27(n)
    43.36(a)
      187273  NM_171059.3  NP_741067.1 


    ENSEMBL Gene Tree for PLCL2 (if available)
    TreeFam Gene Tree for PLCL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLCL2 gene
    PLCD42  PLCD12  PLCE12  PLCB22  PLCZ12  PLCH12  PLCB32  PLCD32  
    PLCH22  PLCB12  PLCB42  PLCL12  
    10 SIMAP similar genes for PLCL2 using alignment to 2 protein entries:     PLCL2_HUMAN (see all proteins):
    PLCL1    DKFZp686K101    PLCD1    PLCZ1    PLCD3    PLCD4
    PLCH2    FLJ00414    PLCB1    PLCB4

    PLCL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3806 SNPs in PLCL2 are shown (see all 3806)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774169481,2
    Cuntested116987360(+) AACAGA/GAAAAA 2 E G mis10--------
    rs1466582521,2
    --16860447(+) CCCAGG/TTTGGA 1 -- us2k10--------
    rs1864001041,2
    --16860556(+) AGTATA/GTATAT 1 -- us2k10--------
    rs22520861,2
    C,F,A,H--16860581(+) TTCCTT/CAGAGG 1 -- us2k122Minor allele frequency- C:0.21EA NS NA WA 3842
    rs1402527051,2
    --16860645(+) CACCCC/GGCCTC 1 -- us2k10--------
    rs1916083421,2
    --16860714(+) CACGAA/GTTGGG 1 -- us2k10--------
    rs1147470871,2
    C,F--16860830(+) GGGGTC/TTCACC 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs64426531,2
    C,F,A,H--16860864(+) GGCTCC/TAGGGA 1 -- us2k110Minor allele frequency- T:0.10NS EA WA NA 1000
    rs1144869631,2
    F--16860879(+) GATCCA/GGGGGA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1452604361,2
    --16860916(+) TCAGCC/TTGGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLCL2 (16844159 - 17094159 bp, first 250kb of PLCL2)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PLCL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675677CNV Deletion23128226
    esv2676563CNV Deletion23128226
    esv2424217CNV Insertion19546169
    nsv819815CNV Loss19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614276    OMIM disorders: --

    5 diseases for PLCL2:    About MalaCards
    primary biliary cirrhosis    multiple sclerosis    rheumatoid arthritis    schizophrenia
    arthritis


    PLCL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLCL2
    Human Genome Epidemiology (HuGE) Navigator: PLCL2 (1 document)

    Export disorders for PLCL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLCL2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with PLCL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
    2. Genome-wide association study identifies 12 new susce ptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1, 4 Mells G.F....Anderson C.A. (2011)
    3. Genetic variants at CD28, PRDM1 and CD2/CD58 are asso ciated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Identification and characterization of a new phospholipase C-like protein, PLC-L(2). (PubMed id 10581172)1, 9 Otsuki M....Takenawa T. (1999)
    6. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (2011)
    7. Exome sequencing supports a de novo mutational paradi gm for schizophrenia. (PubMed id 21822266)1 Xu B....Karayiorgou M. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23228 HGNC: 9064 AceView: PLCL2 Ensembl:ENSG00000154822 euGenes: HUgn23228
    ECgene: PLCL2 H-InvDB: PLCL2

    (According to HUGE)
    About This Section
    HUGE: KIAA1092

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLCL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLCL2 gene:
    Search GeneIP for patents involving PLCL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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