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Aliases for PLCL1 Gene

Aliases for PLCL1 Gene

  • Phospholipase C-Like 1 2 3
  • Phospholipase C-Related But Catalytically Inactive Protein 3 4
  • Phospholipase C-Deleted In Lung Carcinoma 3 4
  • Phospholipase C, Epsilon 2 3
  • PLC-L1 3 4
  • PRIP 3 4
  • Phospholipase C Related, But Catalytically Inactive Protein 3
  • Protein Phosphatase 1, Regulatory Subunit 127 3
  • But Catalytically Inactive Protein 2
  • Phospholipase C Related 2
  • Regulatory Subunit 127 2
  • Protein Phosphatase 1 2
  • PPP1R127 3
  • PLDL1 3
  • PLCL 3
  • PLCE 3

External Ids for PLCL1 Gene

Previous HGNC Symbols for PLCL1 Gene

  • PLCE

Previous GeneCards Identifiers for PLCL1 Gene

  • GC02P197147
  • GC02P197661
  • GC02P198912
  • GC02P199151
  • GC02P199033
  • GC02P198774
  • GC02P198523
  • GC02P198377
  • GC02P198669
  • GC02P190521

Summaries for PLCL1 Gene

GeneCards Summary for PLCL1 Gene

PLCL1 (Phospholipase C-Like 1) is a Protein Coding gene. Among its related pathways are Circadian entrainment and Proton Pump Inhibitor Pathway, Pharmacodynamics. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCH1.

UniProtKB/Swiss-Prot for PLCL1 Gene

  • Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCL1 Gene

Genomics for PLCL1 Gene

Regulatory Elements for PLCL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLCL1 Gene

Chromosome:
2
Start:
197,804,602 bp from pter
End:
198,572,581 bp from pter
Size:
767,980 bases
Orientation:
Plus strand

Genomic View for PLCL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCL1 Gene

Proteins for PLCL1 Gene

  • Protein details for PLCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15111-PLCL1_HUMAN
    Recommended name:
    Inactive phospholipase C-like protein 1
    Protein Accession:
    Q15111
    Secondary Accessions:
    • Q3MJ90
    • Q53SD3
    • Q7Z3S3

    Protein attributes for PLCL1 Gene

    Size:
    1095 amino acids
    Molecular mass:
    122728 Da
    Quaternary structure:
    • Interacts with PPP2CA (By similarity). Interacts with Ins(1,4,5)P3, Ins(1,4,5,6)P4, GABARAP, GABA receptor beta subunits, GABA receptor gamma-2 subunits and PPP1C. May form a ternary complex with GABA receptor beta subunit and GABARAP. The formation of a ternary complex with GABA receptor beta subunit and GABARAP could be the key step for facilitating the association of GABARAP with the GABA receptor gamma-2 subunit and to allow it to be transported at the right destination.

    Alternative splice isoforms for PLCL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCL1 Gene

Proteomics data for PLCL1 Gene at MOPED

Post-translational modifications for PLCL1 Gene

  • Phosphorylated by the catalytic subunit of PKA. Phosphorylation of Thr-93 resulted in dissociation of PPP1C from PRIP1 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCL1 Gene

No data available for DME Specific Peptides for PLCL1 Gene

Domains & Families for PLCL1 Gene

Suggested Antigen Peptide Sequences for PLCL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15111

UniProtKB/Swiss-Prot:

PLCL1_HUMAN :
  • Contains 1 C2 domain.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 PH domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCL1: view

Function for PLCL1 Gene

Molecular function for PLCL1 Gene

UniProtKB/Swiss-Prot Function:
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.

Gene Ontology (GO) - Molecular Function for PLCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004629 phospholipase C activity TAS 7633416
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding --
GO:0008081 phosphoric diester hydrolase activity --
genes like me logo Genes that share ontologies with PLCL1: view
genes like me logo Genes that share phenotypes with PLCL1: view

Animal Models for PLCL1 Gene

MGI Knock Outs for PLCL1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLCL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLCL1 Gene

Localization for PLCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCL1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCL1 Gene COMPARTMENTS Subcellular localization image for PLCL1 gene
Compartment Confidence
plasma membrane 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PLCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PLCL1: view

Pathways & Interactions for PLCL1 Gene

genes like me logo Genes that share pathways with PLCL1: view

Pathways by source for PLCL1 Gene

1 PharmGKB pathway for PLCL1 Gene
1 KEGG pathway for PLCL1 Gene

Interacting Proteins for PLCL1 Gene

Gene Ontology (GO) - Biological Process for PLCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction --
GO:0007214 gamma-aminobutyric acid signaling pathway IEA --
GO:0016042 lipid catabolic process --
GO:0032228 regulation of synaptic transmission, GABAergic IEA --
genes like me logo Genes that share ontologies with PLCL1: view

No data available for SIGNOR curated interactions for PLCL1 Gene

Drugs & Compounds for PLCL1 Gene

(4) Drugs for PLCL1 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Quinacrine Approved Pharma Target, inhibitor 6
cyclic amp Experimental Pharma 0
Calcium Nutra 0
tyrosine Nutra 547

(1) Additional Compounds for PLCL1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phospholipid
genes like me logo Genes that share compounds with PLCL1: view

Transcripts for PLCL1 Gene

Unigene Clusters for PLCL1 Gene

Phospholipase C-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLCL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCL1 Gene

No ASD Table

Relevant External Links for PLCL1 Gene

GeneLoc Exon Structure for
PLCL1
ECgene alternative splicing isoforms for
PLCL1

Expression for PLCL1 Gene

mRNA expression in normal human tissues for PLCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCL1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.5) and Heart - Left Ventricle (x5.1).

Protein differential expression in normal tissues from HIPED for PLCL1 Gene

This gene is overexpressed in Spinal cord (15.3), Prostate (10.8), Frontal cortex (9.0), and Heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLCL1 Gene



SOURCE GeneReport for Unigene cluster for PLCL1 Gene Hs.153322

mRNA Expression by UniProt/SwissProt for PLCL1 Gene

Q15111-PLCL1_HUMAN
Tissue specificity: Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.
genes like me logo Genes that share expression patterns with PLCL1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for PLCL1 Gene

Orthologs for PLCL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLCL1 35
  • 91.93 (n)
  • 96.16 (a)
PLCL1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCL1 35
  • 92.36 (n)
  • 96.26 (a)
PLCL1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcl1 35
  • 88.07 (n)
  • 94.52 (a)
Plcl1 16
Plcl1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLCL1 35
  • 99.85 (n)
  • 99.91 (a)
PLCL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcl1 35
  • 88.13 (n)
  • 94.25 (a)
oppossum
(Monodelphis domestica)
Mammalia PLCL1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLCL1 35
  • 79.07 (n)
  • 86.7 (a)
PLCL1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCL1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plcl1 35
  • 74.77 (n)
  • 82.43 (a)
zebrafish
(Danio rerio)
Actinopterygii plcl1 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea plc-4 36
  • 32 (a)
ManyToMany
pll-1 36
  • 40 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for PLCL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCL1 Gene

ENSEMBL:
Gene Tree for PLCL1 (if available)
TreeFam:
Gene Tree for PLCL1 (if available)

Paralogs for PLCL1 Gene

Paralogs for PLCL1 Gene

(8) SIMAP similar genes for PLCL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLCL1: view

Variants for PLCL1 Gene

Sequence variations from dbSNP and Humsavar for PLCL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs696814 -- 197,823,175(-) CAGTG(C/G)TACAT intron-variant
rs696815 -- 197,823,360(-) ATATA(G/T)AGAGA intron-variant
rs696816 -- 197,824,465(-) AAGTG(C/T)TTGGA intron-variant
rs696817 -- 197,857,501(+) CAAAT(A/G)ATCAG intron-variant
rs700667 -- 197,812,784(-) ACATC(A/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCL1 Gene

Variant ID Type Subtype PubMed ID
nsv834506 CNV Gain 17160897
nsv875698 CNV Gain 21882294
nsv460016 CNV Gain 19166990
esv2632650 CNV Deletion 19546169
esv2721338 CNV Deletion 23290073
esv2671075 CNV Deletion 23128226
esv2572769 CNV Insertion 19546169
esv268161 CNV Insertion 20981092
esv272349 CNV Insertion 20981092
esv1252338 CNV Insertion 17803354
esv1623532 CNV Insertion 17803354
nsv507059 CNV Insertion 20534489
nsv3100 CNV Insertion 18451855
nsv834507 CNV Gain 17160897
esv2721340 CNV Deletion 23290073
esv2721341 CNV Deletion 23290073
esv2659675 CNV Deletion 23128226
esv2721342 CNV Deletion 23290073
esv2008876 CNV Deletion 18987734
esv988447 CNV Deletion 20482838
nsv3101 CNV Loss 18451855
esv2576992 CNV Deletion 19546169

Variation tolerance for PLCL1 Gene

Residual Variation Intolerance Score: 5.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.72; 95.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLCL1 Gene

HapMap Linkage Disequilibrium report
PLCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCL1 Gene

Disorders for PLCL1 Gene

Relevant External Links for PLCL1

Genetic Association Database (GAD)
PLCL1
Human Genome Epidemiology (HuGE) Navigator
PLCL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLCL1
genes like me logo Genes that share disorders with PLCL1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCL1 Gene

Publications for PLCL1 Gene

  1. PLCL1 rs7595412 variation is not associated with hip bone size variation in postmenopausal Danish women. (PMID: 20030815) Cauchi S. … Froguel P. (BMC Med. Genet. 2009) 23 67
  2. Dual activation of phospholipase C-epsilon by Rho and Ras GTPases. (PMID: 18765661) Seifert J.P. … Harden T.K. (J. Biol. Chem. 2008) 23 67
  3. Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. (PMID: 18776929) Liu Y.Z. … Deng H.W. (PLoS ONE 2008) 23 67
  4. Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi. (PMID: 17098795) Eungdamrong N.J. … Iyengar R. (Biophys. J. 2007) 23 67
  5. Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells. (PMID: 16565089) Bourguignon L.Y. … Singleton P. (J. Biol. Chem. 2006) 23 67

Products for PLCL1 Gene

Sources for PLCL1 Gene

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