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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLCL1 Gene

protein-coding GIFtS: 54
GCID: GC02P198669

phospholipase C-like 1

(Previous names: phospholipase C, epsilon )
(Previous symbol: PLCE)

Explore 7 diseases affiliated with
PLCL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase C-Like 1¹ ²		Phospholipase C-Related But Catalytically Inactive Protein² ³
PRIP¹ ² ³		PLC-L1² ³
PLCE¹ ² ⁵		PLDL1² ⁵
PLCL¹ ² ⁵		PLC-L¹
Phospholipase C, Epsilon¹ ²		Inactive Phospholipase C-Like Protein 1²
Phospholipase C-Deleted In Lung Carcinoma² ³		Phospholipase C Related, But Catalytically Inactive Protein²

External Ids:	HGNC: 9063¹	Entrez Gene: 5334²	Ensembl: ENSG00000115896⁷	OMIM: 600597⁵	UniProtKB: Q15111³

Export aliases for PLCL1 gene to outside databases

Previous GC identifers: GC02P197147 GC02P197661 GC02P198912 GC02P199151 GC02P199033 GC02P198774 GC02P198523 GC02P198377 GC02P190521

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PLCL1_HUMAN, Q15111

Function: Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to

phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process

of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of

GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung

carcinoma. Acts as a inhibitor of PPP1C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLCL1 gene promoter:
AhR Pax-6 MIF-1 NF-kappaB Cdc5 Arnt AREB6 SRY Ik-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLCL1 promoter sequence

Search SABiosciences Chromatin IP Primers for PLCL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33

PLCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCL1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P198669: view genomic region (about GC identifiers)

Start:	198,669,426 bp from pter	End:	199,437,305 bp from pter
Size:	767,880 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLCL1_HUMAN, Q15111 (See protein sequence)

Recommended Name: Inactive phospholipase C-like protein 1

Size: 1095 amino acids; 122728 Da

Subunit: Interacts with PPP2CA (By similarity). Interacts with Ins(1,4,5)P3, Ins(1,4,5,6)P4, GABARAP, GABA receptor

beta subunits, GABA receptor gamma-2 subunits and PPP1C. May form a ternary complex with GABA receptor beta subunit

and GABARAP. The formation of a ternary complex with GABA receptor beta subunit and GABARAP could be the key step for

facilitating the association of GABARAP with the GABA receptor gamma-2 subunit and to allow it to be transported at

the right destination

Subcellular location: Cytoplasm (By similarity)

Caution: In the PI-PLC X-box Asn-458 is present instead of the conserved His which is one of the active site residues.

It is therefore expected that this protein lacks catalytic activity

Secondary accessions: Q3MJ90 Q53SD3 Q7Z3S3

Alternative splicing: 2 isoforms: Q15111-1 Q15111-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLCL1: NX_Q15111

Post-translational modifications:

Phosphorylated by the catalytic subunit of PKA. Phosphorylation of Thr-93 resulted in dissociation of PPP1C from PRIP1

(By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15111

PLCL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006217.3

ENSEMBL proteins:

ENSP00000402861 ENSP00000410488 ENSP00000457588 ENSP00000414138

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PLCL1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IEA	--

PLCL1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PLCL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLCL1 for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR015359 PLipase_C_EF-hand-like

IPR011992 EF-hand-like_dom

IPR001192 Pinositol_PLipase_C

IPR001849 Pleckstrin_homology

IPR018029 C2_membr_targeting

Graphical View of Domain Structure for InterPro Entry Q15111

ProtoNet protein and cluster: Q15111

3 Blocks protein families:

IPB000008 C2 domain

IPB000909 Phosphatidylinositol-specific phospholipase C

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: PLCL1_HUMAN, Q15111

Similarity: Contains 1 C2 domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 PI-PLC X-box domain

Similarity: Contains 1 PI-PLC Y-box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PLCL1_HUMAN, Q15111

Function: Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to

phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process

of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of

GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung

carcinoma. Acts as a inhibitor of PPP1C

miRNA Products:		OriGene 3'-UTR Clone: PLCL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCL1
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCL1 (see all 64):
		hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-3653 hsa-miR-519a hsa-miR-10b* hsa-miR-1273d

		SwitchGear 3'UTR luciferase reporter plasmid: PLCL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLCL1 (see all 7) OriGene shRNA RFP: PLCL1 OriGene siRNA: PLCL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PLCL1

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLCL1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLCL1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLCL1 (NM_006226)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PLCL1
		Search LifeMap BioReagents cell lines for PLCL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCL1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphatidylinositol phospholipase C activity	IEA	--
GO:0004629	phospholipase C activity	TAS	7633416
GO:0004871	signal transducer activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005543	phospholipid binding	IEA	--

PLCL1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PLCL1:

Decreased POU5F1-GFP protein e

Animal Models:
Mouse knock-out Plcl1^tm1Mh for PLCL1
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Plcl1):

behavior/neurological

homeostasis/metabolism

mortality/aging

nervous system

PLCL1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Proton Pump Inhibitor Pathway, Pharmacodynamics

Proton Pump Inhibitor Pathway, Pharmacodynamics

1.00

1 PharmGKB Pathway for PLCL1

Proton Pump Inhibitor Pathway, Pharmacodynamics

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PLCL1

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	IEA	--
GO:0007610	behavior	IEA	--
GO:0035556	intracellular signal transduction	IEA	--

PLCL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PLCL1 for compounds About GeneDecksing

EMD Millipore small molecules for PLCL1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PLCL1

10/843 HMDB Compounds for PLCL1 (see all 843) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--
DG(14:0/18:2(9Z,12Z)/0:0)	DAG(14:0/18:2n6) (see all 15)	--	--

1 DrugBank Compound for PLCL1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Quinacrine	--	83-89-6	target	inhibitor	8469910 11207202 1860838 2551803 7573467

4 Novoseek chemical compound relationships for PLCL1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phospholipid	35.3	2	16472663 (2)
calcium	25.7	3	15319437 (1), 17098795 (1)
cyclic amp	23.5	1	11877431 (1)
tyrosine	0	1	15143162 (1)

Search CenterWatch for drugs/clinical trials and news about PLCL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLCL1 gene:

NM_006226.3

Unigene Cluster for PLCL1:

Phospholipase C-like 1

Hs.153322 [show with all ESTs]

Unigene Representative Sequence: NM_006226

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000428675 ENST00000435320(uc010fsp.3 uc002uuv.4) ENST00000487695

ENST00000472193 ENST00000437704

miRNA Products:		OriGene 3'-UTR Clone: PLCL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCL1
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCL1 (see all 64):
		hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-3653 hsa-miR-519a hsa-miR-10b* hsa-miR-1273d

		SwitchGear 3'UTR luciferase reporter plasmid: PLCL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLCL1 (see all 7) OriGene shRNA RFP: PLCL1 OriGene siRNA: PLCL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLCL1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLCL1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLCL1 (NM_006226)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCL1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLCL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat PLCL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLCL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCL1

Additional cDNA sequence:

AK127514.1 AK302673.1 BC101531.1 BC111985.1 BX537442.1 D42108.1

4 DOTS entries:

DT.211899 DT.310474 DT.99979575 DT.120960310

24/40 AceView cDNA sequences (see all 40):

AI332504 BQ128361 AA411387 AA232250 BX118228 AA232851 AI804172 AI091851

AA233025 AK127514 AA911491 BX502013 Z44551 BU753689 D42108 BX537442

AA232745 BF526498 BP340710 BX502097 BG206188 AI983538 AA406325 BV183429

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLCL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAAAAGAAA

About this image

PLCL1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Fetal cardiomyocytes (20 weeks) (Primary Cell)

Heart, Myocardium

Nkx2-1 GFP+ cells (Efficient derivation...)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PLCL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLCL1

SOURCE GeneReport for Unigene cluster: Hs.153322

UniProtKB/Swiss-Prot: PLCL1_HUMAN, Q15111

Tissue specificity: Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression

was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain

SABiosciences Custom PCR Arrays for PLCL1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCL1 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLCL1¹	phospholipase C-like 1	79.07(n) 86.7(a)		424060 XM_421916.3 XP_421916.3
lizard (Anolis carolinensis)	Reptilia	PLCL1⁶	--	83(a)	1 ↔ 1	GL343436.1(288853-303195)
zebrafish (Danio rerio)	Actinopterygii	plce1⁶	phospholipase C, epsilon 1	7(a)	possible ortholog	12(5497166-5606348)
worm (Caenorhabditis elegans)	Secernentea	pll-1⁶ plc-4⁶	PhosphoLipase C family member (plc-4)	35(a) 28(a)	1 ↔ many possible ortholog	III(365948-377557) IV(7509454-7512662)
thale cress (Arabidopsis thaliana)	eudicotyledons	PLC5⁶ ATPLC1⁶ (see all 9)	phosphoinositide phospholipase C 1 (see all 9)	24(a) 24(a) (see all 9)	many ↔ many many ↔ many (see all 9)	5(23709529-23712131) 5(23704231-23706800)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	phospholipase C, putative, expressed (see all 4)	26(a) 23(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(10024184-10026867) 12(23015165-23019784)

ENSEMBL Gene Tree for PLCL1 (if available)
TreeFam Gene Tree for PLCL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PLCL1 gene

PLCG2² PLCD4² PLCD1² PLCG1² PLCB2² PLCZ1² PLCB3² PLCH1²

PLCD3² PLCB1² PLCB4² PLCH2² PLCL2²

8 SIMAP similar genes for PLCL1 using alignment to 3 protein entries: PLCL1_HUMAN (see all proteins):

PLCL2 PLCZ1 PLCD4 DKFZp686K101 PLCD1 PLCH2

FLJ00414 PLCD3

PLCL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60867126^1,2	C,	--	198667474(+)	`CAAGAT/CAATGA`	1	--	us2k¹		2		WA	120
rs145785826^1,2		--	198667722(+)	`ACATGG/TATGGT`	1	--	us2k¹		0	--	--	--	--
rs139318877^1,2		--	198667882(+)	`CTCAGA/GATCTC`	1	--	us2k¹		0	--	--	--	--
rs75547965^1,2	F,	--	198667934(+)	`ACTCTC/GTACAG`	1	--	us2k¹		1		WA	118
rs60810555^1,2	C,	--	198668005(+)	`ATTCCC/TTAGTA`	1	--	us2k¹		2		WA	120
rs149432100^1,2		--	198668025(+)	`TGTCAA/GATCTG`	1	--	us2k¹		0	--	--	--	--
rs144764984^1,2		--	198668026(+)	`GTCAAA/GTCTGA`	1	--	us2k¹		0	--	--	--	--
rs77803264^1,2	F,	--	198668203(+)	`TGATGT/CCCTAG`	1	--	us2k¹		1		NA	120
rs771015^1,2	C,F,A,	--	198668294(-)	`GCTAAC/TAGCAT`	1	--	us2k¹		8		NA WA CSA EA	367
rs148558832^1,2		--	198668339(+)	`AATTAC/TTAATA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLCL1 (198669426 - 198919426 bp, first 250kb of PLCL1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PLCL1
2 CNVs: 98099 98100

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLCL1 for disorders           About GeneDecksing

OMIM gene information: 600597    OMIM disorders: --

7 diseases for PLCL1:    About MalaCards

lung carcinoma non-small cell lung carcinoma carcinoma intracranial aneurysm

squamous cell carcinoma crohn's disease leukemia

1 Novoseek disease relationship for PLCL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	15558028 (1)

Human Genome Epidemiology (HuGE) Navigator: PLCL1 (6 documents)

Export disorders for PLCL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLCL1 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with PLCL1)

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Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma. (PubMed id 7633416)^{1, 2, 3} Kohno T....Yokota J. (1995)
Characterization of the human PRIP-1 gene structure and transcriptional regulation. (PubMed id 16952428)^{1, 2} Murakami A.... Hirata M. (2006)
PLCL1 rs7595412 variation is not associated with hip bone size variation in postmenopausal Danish women. (PubMed id 20030815)^{1, 9} Cauchi S....Froguel P. (2009)
Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. (PubMed id 18776929)^{1, 9} Liu Y.Z....Deng H.W. (2008)
A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)¹ Tao S....Sun J. (2012)
Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype. (PubMed id 22128345)¹ Zhu G....Okada M. (2012)
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922)¹ Ramsuran V....Ndung'u T. (2011)
Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)¹ Elks C.E....Murray A. (2010)
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)¹ Franke A....Parkes M. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5334	HGNC: 9063	AceView: PLCL1	Ensembl:ENSG00000115896	euGenes: HUgn5334
ECgene: PLCL1	H-InvDB: PLCL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PLCL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PLCL1 gene
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Patent Information for PLCL1 gene:
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phospholipase C-like 1

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phospholipase C-like 1

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