Aliases for PLCH2 Gene
External Ids for PLCH2 Gene
Previous HGNC Symbols for PLCH2 Gene
Previous GeneCards Identifiers for PLCH2 Gene
PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
GeneCards Summary for PLCH2 Gene
PLCH2 (Phospholipase C, Eta 2) is a Protein Coding gene. Among its related pathways are Phospholipase-C Pathway and Metabolism. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCH1.
UniProtKB/Swiss-Prot for PLCH2 Gene
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.