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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLCH2 Gene

protein-coding GIFtS: 53
GCID: GC01P002397

phospholipase C, eta 2

(Previous name: phospholipase C-like 4 )
(Previous symbol: PLCL4)

Explore 2 diseases affiliated with
PLCH2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase C, Eta 2¹ ²		Phospholipase C-Eta-2² ³
PLCL4¹ ² ³ ⁵		Phospholipase C-Like Protein 4² ³
PLC-Eta2¹		PLC-L4² ³
PLCeta2¹ ²		EC 3.1.4.11³ ⁸
Phospholipase C-Like 4¹ ²		RP3-395M20.1¹
KIAA0450¹ ³		1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Eta-2²
Phosphoinositide Phospholipase C-Eta-2² ³		1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Eta-2²
Phosphoinositide Phospholipase C-Like 4² ³		Phospholipase C-Eta2²

External Ids:	HGNC: 29037¹	Entrez Gene: 9651²	Ensembl: ENSG00000149527⁷	OMIM: 612836⁵	UniProtKB: O75038³

Export aliases for PLCH2 gene to outside databases

Previous GC identifers: GC01P002347 GC01P001686

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLCH2:

PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes

that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al.,

2005 (PubMed 16107206)).(supplied by OMIM, Jun 2009)

UniProtKB/Swiss-Prot: PLCH2_HUMAN, O75038

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very

sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain

(By similarity)

summary for PLCH2:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the

hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and

1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily

activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth

factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological

functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane

phospholipids.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004350.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLCH2 gene promoter:
AML1a NRSF form 1 NRSF form 2 HEN1 RORalpha1 S8 PPAR-gamma1 HOXA5
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLCH2 promoter sequence

Search SABiosciences Chromatin IP Primers for PLCH2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCH2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.32 Ensembl cytogenetic band: 1p36.32 HGNC cytogenetic band: 1p36.32

PLCH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCH2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P002397: view genomic region (about GC identifiers)

Start:	2,398,898 bp from pter	End:	2,436,969 bp from pter
Size:	38,072 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLCH2_HUMAN, O75038 (See protein sequence)

Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

Size: 1416 amino acids; 154668 Da

Cofactor: Calcium (By similarity)

Subcellular location: Cytoplasm. Cell membrane. Note=Localized predominantly at the plasma membrane (By similarity)

Sequence caution: Sequence=AAH43358.1; Type=Frameshift; Positions=172; Sequence=BAA32295.3; Type=Erroneous initiation;

Note=Translation N-terminally shortened; Sequence=BAC56932.2; Type=Erroneous initiation; Note=Translation N-terminally

shortened;

Secondary accessions: A2VCM3 B9DI80 Q3LUA8 Q86XJ2 Q86XU1 Q86YU7 Q8TEH5 Q8WUS6

Alternative splicing: 5 isoforms: O75038-1 O75038-2 O75038-3 O75038-4 O75038-5 (No experimental confirmation available. Ref.2 (BAC56932) sequence is in conflict in position: 209:Q->L)

Explore the universe of human proteins at neXtProt for PLCH2: NX_O75038

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75038

4/7 DME Specific Peptides for PLCH2 (O75038) (see all 7)

RVDSSNY

QLSRIYP

CGYVLKP

SSHNTYL

PLCH2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055453.2

ENSEMBL proteins:

ENSP00000367744 ENSP00000341313 ENSP00000278878 ENSP00000389803 ENSP00000397289

ENSP00000367747 ENSP00000367749 ENSP00000288766

Reactome Protein details: O75038
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--

PLCH2 for ontologies About GeneDecksing

PLCH2 Antibody Products:

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	Novus Biologicals PLCH2 Antibody
	Search for Antibodies for PLCH2 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for PLCH2

Assay Products for PLCH2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PLCH2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLCH2 for domains About GeneDecksing

5/13 InterPro domains/families (see all 13):

IPR015359 PLipase_C_EF-hand-like

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR001192 Pinositol_PLipase_C

IPR001849 Pleckstrin_homology

Graphical View of Domain Structure for InterPro Entry O75038

ProtoNet protein and cluster: O75038

2 Blocks protein families:

IPB000008 C2 domain

IPB000909 Phosphatidylinositol-specific phospholipase C

UniProtKB/Swiss-Prot: PLCH2_HUMAN, O75038

Similarity: Contains 1 C2 domain

Similarity: Contains 2 EF-hand domains

Similarity: Contains 1 PH domain

Similarity: Contains 1 PI-PLC X-box domain

Similarity: Contains 1 PI-PLC Y-box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PLCH2_HUMAN, O75038

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very

sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain

(By similarity)

Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate +

diacylglycerol

Enzyme Number (IUBMB): EC 3.1.4.11¹ ²

miRNA Products:		OriGene 3'-UTR Clone: PLCH2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCH2
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLCH2 (see all 3) OriGene siRNA: PLCH2
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for PLCH2

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		GenScript: all cDNA clones in your preferred vector: PLCH2 (NM_014638)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PLCH2
		Search LifeMap BioReagents cell lines for PLCH2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCH2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0004435	phosphatidylinositol phospholipase C activity	IEA	--
GO:0004629	phospholipase C activity	--	--
GO:0004871	signal transducer activity	IEA	--
GO:0005509	calcium ion binding	IEA	--

PLCH2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PLCH2:

Decreased influenza A virus in

Increased gamma-H2AX phosphory

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Plch2):

normal

PLCH2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of IP3 and IP4 in the cytosol

Synthesis of IP3 and IP4 in the cytosol

1.00

Inositol phosphate metabolism

0.57

Metabolism

Metabolism

1.00

Proton Pump Inhibitor Pathway, Pharmacodynamics

Proton Pump Inhibitor Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for PLCH2

	Metabolism
	Inositol phosphate metabolism
	Synthesis of IP3 and IP4 in the cytosol

1 PharmGKB Pathway for PLCH2

Proton Pump Inhibitor Pathway, Pharmacodynamics

PLCH2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PLCH2

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/11 Interacting proteins for PLCH2 (ENSP00000367747⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IPMK	ENSP00000363046⁴	STRING: ENSP00000363046
ITPKA	ENSP00000260386⁴	STRING: ENSP00000260386
ITPKB	ENSP00000272117⁴	STRING: ENSP00000272117
ITPKC	ENSP00000263370⁴	STRING: ENSP00000263370
PIP4K2A	ENSP00000365757⁴	STRING: ENSP00000365757

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	--	--
GO:0008150	biological_process	ND	--
GO:0016042	lipid catabolic process	IEA	--
GO:0035556	intracellular signal transduction	IEA	--
GO:0046488	phosphatidylinositol metabolic process	IEA	--

PLCH2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for PLCH2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLCH2 available from Tocris Bioscience About this table

Compound	Action	CAS #
m-3M3FBS	Phospholipase C activator	[200933-14-8]
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
U 73122	Phospholipase C inhibitor	[112648-68-7]
D609	Selective PC-PLC inhibitor	[83373-60-8]

10/1223 HMDB Compounds for PLCH2 (see all 1223) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--

Search CenterWatch for drugs/clinical trials and news about PLCH2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLCH2 gene:

NM_014638.2

Unigene Cluster for PLCH2:

Phospholipase C, eta 2

Hs.170156 [show with all ESTs]

Unigene Representative Sequence: AK122589

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000498669 ENST00000378483 ENST00000343889(uc001ajk.1) ENST00000278878(uc009vle.1)

ENST00000419816 ENST00000473964 ENST00000462379(uc001ajl.1) ENST00000449969(uc001ajj.1)

ENST00000378486(uc010nyz.2 uc001aji.1) ENST00000378488 ENST00000288766

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		SwitchGear 3'UTR luciferase reporter plasmid: PLCH2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLCH2 (see all 3) OriGene siRNA: PLCH2
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		GenScript: all cDNA clones in your preferred vector: PLCH2 (NM_014638)
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		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PLCH2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCH2

Additional cDNA sequence:

AB007919.2 AK074149.1 AK122589.1 AK122591.2 BC019679.1 BC037356.1 BC043358.1 BC044630.1

BC050037.1 BC128207.1 BC128208.1 BC139747.1 BC144620.1 DQ176850.1

8 DOTS entries:

DT.306548 DT.97842876 DT.99948021 DT.100776121 DT.91937606 DT.100776122 DT.121425266 DT.75157885

24/61 AceView cDNA sequences (see all 61):

BC037356 BM310944 AL134214 BC044630 BF516265 AL118780 AB007919 BE858584

BC050037 BI791517 BM710160 BI712927 AK122589 BC019679 BM671796 BC043358

BX279976 BM701744 BM710378 CA777527 BE908459 CA312958 BF594783 AI273249

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PLCH2 (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:							-																														-
SP2:																																					-
SP3:																																					-						-
SP4:																																					-
SP5:			-		-		-						-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	24a	·	24b	^	25	^	26a	·	26b
SP1:
SP2:			-		-
SP3:			-		-
SP4:
SP5:

ECgene alternative splicing isoforms for PLCH2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLCH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACGCCTGC

About this image

PLCH2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Granulosa Cells

Ovary

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See PLCH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLCH2

SOURCE GeneReport for Unigene cluster: Hs.170156

UniProtKB/Swiss-Prot: PLCH2_HUMAN, O75038

Tissue specificity: Expressed in retina and kidney

SABiosciences Custom PCR Arrays for PLCH2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLCH2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCH2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCH2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCH2 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLCH2¹	phospholipase C, eta 2	69.32(n) 74.64(a)		428180 XM_425738.3 XP_425738.2
lizard (Anolis carolinensis)	Reptilia	PLCH2⁶	--	66(a)	1 ↔ 1	GL343848.1(38473-103113)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.19342²	Transcribed sequence with weak similarity to protein more	76.9(n)		AL878579.2
zebrafish (Danio rerio)	Actinopterygii	plch2¹	phospholipase C, eta 2	67.47(n) 69.94(a)		560919 XM_684319.5 XP_689411.5
worm (Caenorhabditis elegans)	Secernentea	plc-4⁶	PhosphoLipase C family member (plc-4)	29(a)	possible ortholog	IV(7509454-7512662)
thale cress (Arabidopsis thaliana)	eudicotyledons	PLC4¹	phosphoinositide phospholipase C 4	44.25(n) 37.26(a)		835984 NM_125257.2 NP_200678.2
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	phospholipase C, putative, expressed (see all 4)	27(a) 25(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(10024184-10026867) 5(1535692-1541555)

ENSEMBL Gene Tree for PLCH2 (if available)
TreeFam Gene Tree for PLCH2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PLCH2 gene

PLCG2² PLCD4² PLCD1² PLCG1² PLCB2² PLCZ1² PLCB3² PLCH1²

PLCD3² PLCB1² PLCB4² PLCL1² PLCL2²

7 SIMAP similar genes for PLCH2 using alignment to 6 protein entries: PLCH2_HUMAN (see all proteins):

FLJ00414 PLCH1 PLCL1 PLCD4 PLCL2 PLCD3

PLCZ1

PLCH2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs70956305^1,2	C,	--	2405835(+)	`AGGAA-/GGGGAT`	1	--	us2k¹		3		NA CSA	6
rs147635271^1,2		--	2405952(+)	`CCAGGA/CACTCT`	1	--	us2k¹		0	--	--	--	--
rs55817548^1,2	F,	--	2405997(+)	`GATGGC/TGGCCT`	1	--	us2k¹		1		WA	118
rs142307201^1,2		--	2406086(+)	`GCCTTA/GGGGAG`	1	--	us2k¹		0	--	--	--	--
rs114634746^1,2	F,	--	2406104(+)	`GAGGGA/TTGGGT`	1	--	us2k¹		1		NA	120
rs182588085^1,2		--	2406329(+)	`CCTGCA/GCTGCC`	1	--	us2k¹		0	--	--	--	--
rs188388511^1,2		--	2406343(+)	`TACACA/GGTGGC`	1	--	us2k¹		0	--	--	--	--
rs192879644^1,2		--	2406355(+)	`TTCCCC/TGAGGC`	1	--	us2k¹		0	--	--	--	--
rs13376340^1,2	C,F,H,	--	2406366(+)	`CCTGTC/GTTCCT`	1	--	us2k¹		5		NS EA WA	536
rs115702045^1,2	C,F,	--	2406472(+)	`CTTCCG/ACCGAG`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for PLCH2 (2398898 - 2436969 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for PLCH2
7 CNVs: 29819 53347 29815 29818 29820 9866 29817

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLCH2 for disorders           About GeneDecksing

OMIM gene information: 612836    OMIM disorders: --

2 diseases for PLCH2:    About MalaCards

immunodeficiency neuronitis

Export disorders for PLCH2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLCH2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with PLCH2)

Utopia: connect your pdf to the dynamic
world of online information

A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme. (PubMed id 15899900)^{1, 3, 9} Nakahara M....Fukami K. (2005)
Molecular cloning and characterization of PLC-eta2. (PubMed id 16107206)^{1, 2} Zhou Y.... Harden T.K. (2005)
Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)^{1, 2} Seki N.... Ohara O. (1997)
Activation of human phospholipase C-eta2 by Gbetagamma. (PubMed id 18361507)^{1, 9} Zhou Y....Harden T.K. (2008)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)¹ Anderson C.A....Rioux J.D. (2011)
Role of phosphoinositide-specific phospholipase C I^2 in isolated and syndromic mental retardation. (PubMed id 21474938)¹ Lo Vasco V.R. (2011)
Investigating SNPs flanking the D1S80 locus in a Tami l population from India. (PubMed id 20649401)¹ Balamurugan K....Tracey M. (2010)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes. (PubMed id 15583837)¹ Stewart A.J....Farquharson C. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9651	HGNC: 29037	AceView: PLCL4	Ensembl:ENSG00000149527	euGenes: HUgn9651
ECgene: PLCH2	H-InvDB: PLCH2

(According to HUGE)
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HUGE: KIAA0450

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PLCH2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PLCH2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PLCH2 gene:
Search GeneIP for patents involving PLCH2

GeneCards and IP:
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