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Aliases for PLCH2 Gene

Aliases for PLCH2 Gene

  • Phospholipase C, Eta 2 2 3
  • PLCL4 3 4 6
  • Phosphoinositide Phospholipase C-Like 4 3 4
  • Phosphoinositide Phospholipase C-Eta-2 3 4
  • Phospholipase C-Like Protein 4 3 4
  • Phospholipase C-Like 4 2 3
  • EC 3.1.4.11 4 64
  • PLC-Eta2 3 4
  • PLC-L4 3 4
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Eta-2 3
  • Phospholipase C-Eta-2 4
  • Phospholipase C-Eta2 3
  • KIAA0450 4
  • PLCeta2 3

External Ids for PLCH2 Gene

Previous Symbols for PLCH2 Gene

  • PLCL4

Summaries for PLCH2 Gene

Entrez Gene Summary for PLCH2 Gene

  • PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]

GeneCards Summary for PLCH2 Gene

PLCH2 (Phospholipase C, Eta 2) is a Protein Coding gene. Among its related pathways are Phospholipase-C Pathway and Metabolism. GO annotations related to this gene include calcium ion binding and signal transducer activity. An important paralog of this gene is PLCH1.

UniProtKB/Swiss-Prot for PLCH2 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).

Tocris Summary for PLCH2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCH2 Gene

Genomics for PLCH2 Gene

Genomic Location for PLCH2 Gene

Start:
2,425,980 bp from pter
End:
2,505,532 bp from pter
Size:
79,553 bases
Orientation:
Plus strand

Genomic View for PLCH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCH2 Gene

Regulatory Elements for PLCH2 Gene

Proteins for PLCH2 Gene

  • Protein details for PLCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75038-PLCH2_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
    Protein Accession:
    O75038
    Secondary Accessions:
    • A2VCM3
    • B9DI80
    • Q3LUA8
    • Q86XJ2
    • Q86XU1
    • Q86YU7
    • Q8TEH5
    • Q8WUS6

    Protein attributes for PLCH2 Gene

    Size:
    1416 amino acids
    Molecular mass:
    154668 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH43358.1; Type=Frameshift; Positions=172; Evidence={ECO:0000305}; Sequence=BAA32295.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC56932.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLCH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCH2 Gene

Proteomics data for PLCH2 Gene at MOPED

Selected DME Specific Peptides for PLCH2 Gene

Post-translational modifications for PLCH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCH2 Gene

Domains for PLCH2 Gene

Gene Families for PLCH2 Gene

HGNC:
  • EFHAND :EF-hand domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

PLCH2_HUMAN
Domain:
  • Contains 1 C2 domain.:
    • O75038
  • Contains 2 EF-hand domains.:
    • O75038
  • Contains 1 PH domain.:
    • O75038
  • Contains 1 PI-PLC X-box domain.:
    • O75038
  • Contains 1 PI-PLC Y-box domain.:
    • O75038
genes like me logo Genes that share domains with PLCH2: view

Function for PLCH2 Gene

Molecular function for PLCH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
UniProtKB/Swiss-Prot Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).

Enzyme Numbers (IUBMB) for PLCH2 Gene

Gene Ontology (GO) - Molecular Function for PLCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004629 phospholipase C activity --
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PLCH2: view

Phenotypes for PLCH2 Gene

MGI mutant phenotypes for PLCH2:
inferred from 1 alleles
GenomeRNAi human phenotypes for PLCH2:
genes like me logo Genes that share phenotypes with PLCH2: view

miRNA for PLCH2 Gene

miRTarBase miRNAs that target PLCH2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PLCH2 Gene

Localization for PLCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCH2 Gene

Cytoplasm. Cell membrane. Note=Localized predominantly at the plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCH2 Gene COMPARTMENTS Subcellular localization image for PLCH2 gene
Compartment Confidence
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PLCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PLCH2: view

Pathways for PLCH2 Gene

genes like me logo Genes that share pathways with PLCH2: view

Pathways by source for PLCH2 Gene

1 Qiagen pathway for PLCH2 Gene
1 PharmGKB pathway for PLCH2 Gene

Interacting Proteins for PLCH2 Gene

Gene Ontology (GO) - Biological Process for PLCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0007165 signal transduction --
GO:0008150 biological_process ND --
GO:0008152 metabolic process --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLCH2: view

Compounds for PLCH2 Gene

(5) Tocris Compounds for PLCH2 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
FIPI Phospholipase D inhibitor [939055-18-2]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]

(1223) HMDB Compounds for PLCH2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
genes like me logo Genes that share compounds with PLCH2: view

Transcripts for PLCH2 Gene

Unigene Clusters for PLCH2 Gene

Phospholipase C, eta 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: - - - - - - - - - - - - - - - - - - - -
SP6: - -
SP7:

ExUns: 24a · 24b ^ 25 ^ 26a · 26b
SP1:
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for PLCH2 Gene

GeneLoc Exon Structure for
PLCH2
ECgene alternative splicing isoforms for
PLCH2

Expression for PLCH2 Gene

mRNA expression in normal human tissues for PLCH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCH2 Gene

This gene is overexpressed in Brain - Cerebellum (5.9), Skin - Not Sun Exposed (Suprapubic) (5.5), Brain - Cerebellar Hemisphere (5.3), and Skin - Sun Exposed (Lower leg) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLCH2 Gene

SOURCE GeneReport for Unigene cluster for PLCH2 Gene Hs.170156

mRNA Expression by UniProt/SwissProt for PLCH2 Gene

O75038-PLCH2_HUMAN
Tissue specificity: Expressed in retina and kidney.
genes like me logo Genes that share expressions with PLCH2: view

Orthologs for PLCH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCH2 36
  • 98.99 (n)
  • 98.94 (a)
PLCH2 37
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLCH2 36
  • 85.32 (n)
  • 83.48 (a)
PLCH2 37
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCH2 36
  • 86.18 (n)
  • 87.46 (a)
PLCH2 37
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plch2 36
  • 83.55 (n)
  • 83.64 (a)
Plch2 16
Plch2 37
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLCH2 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLCH2 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plch2 36
  • 83.38 (n)
  • 84.38 (a)
chicken
(Gallus gallus)
Aves PLCH2 36
  • 68.98 (n)
  • 73.72 (a)
PLCH2 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCH2 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487353 36
  • 71.58 (n)
  • 81.13 (a)
Str.19342 36
zebrafish
(Danio rerio)
Actinopterygii plch2 36
  • 67.43 (n)
  • 69.85 (a)
PLCH2 (1 of 2) 37
  • 69 (a)
OneToMany
plch2a 37
  • 68 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40116 36
  • 43.21 (n)
  • 37.57 (a)
rice
(Oryza sativa)
Liliopsida Os07g0694000 36
  • 46.73 (n)
  • 35.25 (a)
Species with no ortholog for PLCH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLCH2 Gene

ENSEMBL:
Gene Tree for PLCH2 (if available)
TreeFam:
Gene Tree for PLCH2 (if available)

Paralogs for PLCH2 Gene

Paralogs for PLCH2 Gene

Selected SIMAP similar genes for PLCH2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PLCH2: view

Variants for PLCH2 Gene

Sequence variations from dbSNP and Humsavar for PLCH2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12219 -- 2,505,339(+) CCTCC(A/G)CCCCT utr-variant-3-prime
rs749719 -- 2,457,996(-) GGCCT(C/T)CTTGG intron-variant
rs749720 -- 2,458,263(-) GTCCC(A/G)TCCTC intron-variant
rs867809 -- 2,450,183(+) CCTCG(A/G)CGGGG intron-variant
rs867810 -- 2,450,129(+) CAGGC(A/G)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCH2 Gene

Variant ID Type Subtype PubMed ID
dgv64n71 CNV Loss 21882294
dgv69n71 CNV Loss 21882294
dgv71n71 CNV Loss 21882294
dgv72n71 CNV Loss 21882294
dgv74n71 CNV Loss 21882294
dgv75n71 CNV Loss 21882294
nsv470684 CNV Loss 18288195
dgv76n71 CNV Loss 21882294
dgv1n27 CNV Loss 19166990
dgv77n71 CNV Gain 21882294
dgv78n71 CNV Gain+Loss 21882294
dgv79n71 CNV Loss 21882294
nsv470685 CNV Gain 18288195
dgv80n71 CNV Loss 21882294
dgv81n71 CNV Loss 21882294
nsv871726 CNV Loss 21882294
nsv870655 CNV Loss 21882294
nsv871912 CNV Gain 21882294
nsv871255 CNV Loss 21882294
nsv823920 CNV Gain 20364138
esv2719473 CNV Deletion 23290073
nsv818222 CNV Loss 17921354
esv2719584 CNV Deletion 23290073

Relevant External Links for PLCH2 Gene

HapMap Linkage Disequilibrium report
PLCH2

Disorders for PLCH2 Gene

No disorders were found for PLCH2 Gene.

No data available for UniProtKB/Swiss-Prot for PLCH2 Gene

Publications for PLCH2 Gene

  1. A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme. (PMID: 15899900) Nakahara M. … Fukami K. (J. Biol. Chem. 2005) 2 3 23
  2. Activation of human phospholipase C-eta2 by Gbetagamma. (PMID: 18361507) Zhou Y. … Harden T.K. (Biochemistry 2008) 3 23
  3. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4
  4. Molecular cloning and characterization of PLC-eta2. (PMID: 16107206) Zhou Y. … Harden T.K. (Biochem. J. 2005) 3 4
  5. Investigating SNPs flanking the D1S80 locus in a Tamil population from India. (PMID: 20649401) Balamurugan K. … Tracey M. (Hum. Biol. 2010) 3

Products for PLCH2 Gene

Sources for PLCH2 Gene

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