Aliases for PLCH1 Gene
External Ids for PLCH1 Gene
Previous HGNC Symbols for PLCH1 Gene
Previous GeneCards Identifiers for PLCH1 Gene
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
GeneCards Summary for PLCH1 Gene
PLCH1 (Phospholipase C Eta 1) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Inositol phosphate metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCH2.
UniProtKB/Swiss-Prot for PLCH1 Gene
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.