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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLCH1 Gene

protein-coding GIFtS: 57
GCID: GC03M155094

phospholipase C, eta 1

(Previous name: phospholipase C-like 3 )
(Previous symbol: PLCL3)

Explore 1 disease affiliated with
PLCH1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase C, Eta 1¹ ²		EC 3.1.4.11³ ⁸
PLCL3¹ ² ³ ⁵		DKFZp434C1372¹
KIAA1069¹ ³ ⁵		MGC117152¹
Phospholipase C-Like 3¹ ²		PLCeta1¹
Phosphoinositide Phospholipase C-Eta-1² ³		1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Eta-1²
Phospholipase C-Eta-1² ³		1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Eta-1²
Phospholipase C-Like Protein 3² ³		Phospholipase C-Eta1a²
PLC-L3² ³		Phospholipase C-Eta1b²
PLC-Eta-1¹		PLC Eta 1²

External Ids:	HGNC: 29185¹	Entrez Gene: 23007²	Ensembl: ENSG00000114805⁷	OMIM: 612835⁵	UniProtKB: Q4KWH8³

Export aliases for PLCH1 gene to outside databases

Previous GC identifers: GC03M156577 GC03M156680 GC03M152592

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLCH1:

PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes

that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol

1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 (PubMed 15702972)).(supplied by OMIM, Jun 2009)

UniProtKB/Swiss-Prot: PLCH1_HUMAN, Q4KWH8

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes

summary for PLCH1:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the

hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and

1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily

activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth

factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological

functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane

phospholipids.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLCH1 gene promoter:
c-Fos AP-1 POU6F1 (c2) CUTL1 C/EBPalpha AREB6 FOXO4 FOXO1a c-Jun FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLCH1 promoter sequence

Search SABiosciences Chromatin IP Primers for PLCH1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCH1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.31 Ensembl cytogenetic band: 3q25.31 HGNC cytogenetic band: 3q25

PLCH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCH1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M155094: view genomic region (about GC identifiers)

Start:	155,093,369 bp from pter	End:	155,462,856 bp from pter
Size:	369,488 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLCH1_HUMAN, Q4KWH8 (See protein sequence)

Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

Size: 1693 amino acids; 189223 Da

Cofactor: Calcium

Subcellular location: Cytoplasm. Membrane

Sequence caution: Sequence=BAB14129.1; Type=Erroneous initiation;

Secondary accessions: Q29RV9 Q4KWH9 Q68CN0 Q86XK4 Q9H9U2 Q9UPT3

Alternative splicing: 4 isoforms: Q4KWH8-1 Q4KWH8-2 Q4KWH8-3 Q4KWH8-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLCH1: NX_Q4KWH8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q4KWH8

4 DME Specific Peptides for PLCH1 (Q4KWH8)

CGYVLKP

SSHNTYL

HGYTLTSK

ELSDLVVY

PLCH1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001124432.1 NP_001124433.1 NP_055811.1

ENSEMBL proteins:

ENSP00000419100 ENSP00000417502 ENSP00000402759 ENSP00000345988 ENSP00000335469

ENSP00000412977

Reactome Protein details: Q4KWH8
Human Recombinant Protein Products for PLCH1:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	IDA	15702972
GO:0005829	cytosol	IEA	--
GO:0031965	nuclear membrane	IDA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

PLCH1 for ontologies About GeneDecksing

PLCH1 Antibody Products:

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	Novus Biologicals PLCH1 Antibodies
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Assay Products for PLCH1:

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	GenScript Custom Assay Services for PLCH1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLCH1 for domains About GeneDecksing

5/13 InterPro domains/families (see all 13):

IPR015359 PLipase_C_EF-hand-like

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR001192 Pinositol_PLipase_C

IPR001849 Pleckstrin_homology

Graphical View of Domain Structure for InterPro Entry Q4KWH8

ProtoNet protein and cluster: Q4KWH8

2 Blocks protein families:

IPB000008 C2 domain

IPB000909 Phosphatidylinositol-specific phospholipase C

UniProtKB/Swiss-Prot: PLCH1_HUMAN, Q4KWH8

Similarity: Contains 1 C2 domain

Similarity: Contains 2 EF-hand domains

Similarity: Contains 1 PH domain

Similarity: Contains 1 PI-PLC X-box domain

Similarity: Contains 1 PI-PLC Y-box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PLCH1_HUMAN, Q4KWH8

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes

Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate +

diacylglycerol

Enzyme Number (IUBMB): EC 3.1.4.11¹ ²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphatidylinositol phospholipase C activity	IEA	--
GO:0004871	signal transducer activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005543	phospholipid binding	IEA	--
GO:0050429	calcium-dependent phospholipase C activity	IDA	15702972

PLCH1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PLCH1:

Synthetic lethal with c-Myc af

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PLCH1

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PLCH1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCH1
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCH1 (see all 25):
		hsa-miR-411* hsa-miR-3685 hsa-miR-495 hsa-miR-379* hsa-miR-520d-5p hsa-miR-2110 hsa-miR-128 hsa-miR-944

		SwitchGear 3'UTR luciferase reporter plasmid: PLCH1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PLCH1

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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLCH1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLCH1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): PLCH1 (NM_014996)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCH1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of IP3 and IP4 in the cytosol

Synthesis of IP3 and IP4 in the cytosol

1.00

Inositol phosphate metabolism

0.57

D-myo-inositol-5-phosphate metabolism

D-myo-inositol-5-phosphate metabolism

1.00

D-myo-inositol (1,4,5)-trisphosphate biosynthesis

0.50

Metabolism

Metabolism

1.00

Proton Pump Inhibitor Pathway, Pharmacodynamics

Proton Pump Inhibitor Pathway, Pharmacodynamics

1.00

Inositol phosphate metabolism

superpathway of inositol phosphate compounds

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

4 BioSystems Pathways for PLCH1

	D-myo-inositol-5-phosphate metabolism
	D-myo-inositol (1,4,5)-trisphosphate biosynthesis
	phospholipases
	superpathway of inositol phosphate compounds

3 Reactome Pathways for PLCH1

	Metabolism
	Inositol phosphate metabolism
	Synthesis of IP3 and IP4 in the cytosol

1 PharmGKB Pathway for PLCH1

Proton Pump Inhibitor Pathway, Pharmacodynamics

PLCH1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PLCH1

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/11 Interacting proteins for PLCH1 (Q4KWH8³ ENSP00000345988⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EGFR	P00533³, ENSP00000275493⁴	I2D: score=1 STRING: ENSP00000275493
IPMK	ENSP00000363046⁴	STRING: ENSP00000363046
ITPKA	ENSP00000260386⁴	STRING: ENSP00000260386
ITPKB	ENSP00000272117⁴	STRING: ENSP00000272117
ITPKC	ENSP00000263370⁴	STRING: ENSP00000263370

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016042	lipid catabolic process	IEA	--
GO:0048015	phosphatidylinositol-mediated signaling	IDA	15702972

PLCH1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLCH1 available from Tocris Bioscience About this table

Compound	Action	CAS #
m-3M3FBS	Phospholipase C activator	[200933-14-8]
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
U 73122	Phospholipase C inhibitor	[112648-68-7]
D609	Selective PC-PLC inhibitor	[83373-60-8]

10/1223 HMDB Compounds for PLCH1 (see all 1223) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--

Search CenterWatch for drugs/clinical trials and news about PLCH1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLCH1 gene (3 alternative transcripts):

NM_001130960.1 NM_001130961.1 NM_014996.2

Unigene Cluster for PLCH1:

Phospholipase C, eta 1

Hs.567423 [show with all ESTs]

Unigene Representative Sequence: NM_001130961

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000494598 ENST00000460012 ENST00000447496 ENST00000340059 ENST00000469040

ENST00000334686(uc021xgf.1) ENST00000414191(uc021xgd.1 uc021xge.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCH1
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCH1 (see all 25):
		hsa-miR-411* hsa-miR-3685 hsa-miR-495 hsa-miR-379* hsa-miR-520d-5p hsa-miR-2110 hsa-miR-128 hsa-miR-944

		SwitchGear 3'UTR luciferase reporter plasmid: PLCH1 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against PLCH1

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		GenScript: all cDNA clones in your preferred vector (see all 3): PLCH1 (NM_014996)
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Additional cDNA sequence:

AB028992.1 AK022610.1 AK093601.1 AK096620.1 AY691170.1 AY691171.1 BC043248.2 BC113950.1

CR749869.1

8 DOTS entries:

DT.210190 DT.91980796 DT.100745056 DT.95267141 DT.120856176 DT.99927687 DT.40293616 DT.95255241

24/47 AceView cDNA sequences (see all 47):

CD243832 CR749869 AK022610 AK093601 AA912422 AB028992 BC043248 BM925474

BM722602 AI860667 AA629266 AU124862 AW955365 AW665865 CD642760 Z42548

AK096620 BM682185 AW969480 BM975788 BM729274 BU742547 BI828261 Z45541

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PLCH1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22
SP1:
SP2:																																									-
SP3:																																					-				-		-

ECgene alternative splicing isoforms for PLCH1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLCH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATATAAT

About this image

PLCH1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PLCH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLCH1

SOURCE GeneReport for Unigene cluster: Hs.567423

UniProtKB/Swiss-Prot: PLCH1_HUMAN, Q4KWH8

Tissue specificity: Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and

spinal cord

SABiosciences Custom PCR Arrays for PLCH1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLCH1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLCH1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCH1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCH1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCH1 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLCH1¹	phospholipase C, eta 1	68.56(n) 69.03(a)		425030 XM_422832.3 XP_422832.3
lizard (Anolis carolinensis)	Reptilia	-- --	--	89(a) 58(a)	1 ↔ many 1 ↔ many	3(15966446-15991014) 3(16000184-16048765)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.18757²	Transcribed sequence with weak similarity to protein more	79.81(n)		AL885390.2
zebrafish (Danio rerio)	Actinopterygii	LOC566479¹	novel protein similar to H.sapiens PLCH1, phospholipase more	62.84(n) 63.72(a)		566479 XM_689749.4 XP_694841.4
worm (Caenorhabditis elegans)	Secernentea	plc-4⁶	PhosphoLipase C family member (plc-4)	29(a)	possible ortholog	IV(7509454-7512662)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATPLC1⁶ AT3G55940⁶ (see all 9)	phosphoinositide phospholipase C 7 (see all 9)	25(a) 24(a) (see all 9)	many ↔ many many ↔ many (see all 9)	5(23704231-23706800) 3(20747787-20750184)
rice (Oryza sativa)	Liliopsida	Os05g0127200¹	hypothetical protein	45.62(n) 36.87(a)		4337686 NM_001061066.1 NP_001054531.1

ENSEMBL Gene Tree for PLCH1 (if available)
TreeFam Gene Tree for PLCH1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PLCH1 gene

PLCG2² PLCD4² PLCD1² PLCG1² PLCB2² PLCZ1² PLCB3² PLCD3²

PLCB1² PLCB4² PLCH2² PLCL1² PLCL2²

5 SIMAP similar genes for PLCH1 using alignment to 1 protein entry: PLCH1_HUMAN:

FLJ00414 PLCH2 PLCD4 PLCD3 PLCZ1

PLCH1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78298969^1,2	F	--	155197196(+)	`ACCCCC/GAACCT`	3	--	ds500¹		1		WA	118
rs150545378^1,2		--	155197276(+)	`ACATTA/GCAAAG`	3	--	ds500¹		0	--	--	--	--
rs190171689^1,2		--	155197342(+)	`TCCCCC/GACCCA`	3	--	ds500¹		0	--	--	--	--
rs73874814^1,2	C	--	155197407(+)	`CAACCA/GGTTCA`	3	--	ds500¹		2		WA	120
rs182769683^1,2		--	155197582(+)	`TTGTCA/GCAAAC`	3	--	ds500¹		0	--	--	--	--
rs115973142^1,2	C,F	--	155197614(+)	`GCTGAG/CTGCTT`	3	--	ds500¹		1		NA	120
rs186775636^1,2	C	--	155197626(+)	`AACTCA/GATAGT`	3	--	ds500¹		0	--	--	--	--
rs139504829^1,2		--	155197722(+)	`CATCAG/TTGCAG`	3	--	ut3¹		0	--	--	--	--
rs35240379^1,2	C	--	155197738(+)	`AAAAA-/ACAAAG`	3	--	ut3¹		1		NA	2
rs149684895^1,2		--	155197760(+)	`AGGGAC/TATCTG`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLCH1 (155093369 - 155343369 bp, first 250kb of PLCH1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for PLCH1
2 CNVs: 98495 98494
4 Indels: 46313 27191 62116 40573

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLCH1 for disorders           About GeneDecksing

OMIM gene information: 612835    OMIM disorders: --

1 disease for PLCH1:    About MalaCards

immunodeficiency

Human Genome Epidemiology (HuGE) Navigator: PLCH1 (3 documents)

Export disorders for PLCH1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLCH1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with PLCH1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and characterization of a novel phospholipase C, PLC-eta. (PubMed id 15702972)^{1, 2, 3} Hwang J.-I.... Suh P.-G. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{1, 2} Kikuno R....Ohara O. (1999)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C sign aling cascade. (PubMed id 20336759)¹ Yang Y....Lu Y. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23007	HGNC: 29185	AceView: PLCL3	Ensembl:ENSG00000114805	euGenes: HUgn23007
ECgene: PLCH1	H-InvDB: PLCH1

(According to HUGE)
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HUGE: KIAA1069

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PLCH1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PLCH1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PLCH1 gene:
Search GeneIP for patents involving PLCH1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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phospholipase C, eta 1

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