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Aliases for PLCG2 Gene

Aliases for PLCG2 Gene

  • Phospholipase C Gamma 2 2 3 5
  • Phospholipase C, Gamma 2 (Phosphatidylinositol-Specific) 2 3
  • Phosphoinositide Phospholipase C-Gamma-2 3 4
  • Phospholipase C-IV 3 4
  • PLC-Gamma-2 3 4
  • EC 3.1.4.11 4 61
  • PLC-IV 3 4
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2 3
  • Phospholipase C-Gamma-2 4
  • APLAID 3
  • FCAS3 3

External Ids for PLCG2 Gene

Previous GeneCards Identifiers for PLCG2 Gene

  • GC16P072654
  • GC16P082773
  • GC16P081551
  • GC16P081593
  • GC16P081569
  • GC16P080370
  • GC16P081812
  • GC16P067566

Summaries for PLCG2 Gene

Entrez Gene Summary for PLCG2 Gene

  • The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]

GeneCards Summary for PLCG2 Gene

PLCG2 (Phospholipase C Gamma 2) is a Protein Coding gene. Diseases associated with PLCG2 include Autoinflammation, Antibody Deficiency, And Immune Dysregulation Syndrome and Familial Cold Autoinflammatory Syndrome 3. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Proton Pump Inhibitor Pathway, Pharmacodynamics. GO annotations related to this gene include signal transducer activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is PLCG1.

UniProtKB/Swiss-Prot for PLCG2 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Tocris Summary for PLCG2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCG2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCG2 Gene

Genomics for PLCG2 Gene

Regulatory Elements for PLCG2 Gene

Enhancers for PLCG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G081829 1.8 FANTOM5 Ensembl ENCODE dbSUPER 37.6 +93.4 93404 5.6 PKNOX1 WRNIP1 RAD21 EGR1 ZNF143 RELB ETV6 IKZF2 CREM SMAD5 PLCG2 CMIP GC16M081818 GC16P081959
GH16G081841 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.4 +103.0 103003 1.9 HDGF ZFP64 RELB ETV6 IKZF2 EGR2 CBFB ZNF426 JUNB GATAD2B PLCG2 ENSG00000261141 ENSG00000260213 C16orf46 ENSG00000260495 CMIP GC16M081818 GC16P081959
GH16G081813 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.5 +80.0 80004 12.2 HDGF PKNOX1 ZNF133 WRNIP1 SIN3A FEZF1 GATA2 ELK1 ZNF143 JUNB PLCG2 ENSG00000260495 ENSG00000261141 GAN CMIP GC16M081818 GC16P081959
GH16G081835 1.3 Ensembl ENCODE dbSUPER 27.4 +97.5 97525 2.0 HDGF FOXA2 EBF1 RELA POLR2A EED SCRT2 ETV6 IKZF2 CREM PLCG2 GC16M081818 GC16P081959
GH16G081795 1.4 Ensembl ENCODE dbSUPER 20.8 +58.9 58872 4.2 HDGF PKNOX1 WRNIP1 SIN3A ZNF766 ELK1 ZNF143 ZNF207 JUNB TBX21 PLCG2 GC16M081818
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLCG2 on UCSC Golden Path with GeneCards custom track

Promoters for PLCG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088530 242 1401 PKNOX1 CREB3L1 SIN3A GLIS2 ZNF207 SP3 REST TBX21 SMARCB1 ZNF579

Genomic Location for PLCG2 Gene

Chromosome:
16
Start:
81,739,097 bp from pter
End:
81,962,693 bp from pter
Size:
223,597 bases
Orientation:
Plus strand

Genomic View for PLCG2 Gene

Genes around PLCG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCG2 Gene

Proteins for PLCG2 Gene

  • Protein details for PLCG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16885-PLCG2_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    Protein Accession:
    P16885
    Secondary Accessions:
    • D3DUL3
    • Q3ZTS2
    • Q59H45
    • Q969T5

    Protein attributes for PLCG2 Gene

    Size:
    1265 amino acids
    Molecular mass:
    147870 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated).
    SequenceCaution:
    • Sequence=AAA60112.1; Type=Frameshift; Positions=1242; Evidence={ECO:0000305}; Sequence=AAQ76815.1; Type=Frameshift; Positions=1242; Evidence={ECO:0000305}; Sequence=BAD92151.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA32194.1; Type=Frameshift; Positions=1242; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLCG2 Gene

neXtProt entry for PLCG2 Gene

Selected DME Specific Peptides for PLCG2 Gene

P16885:
  • RVDSSNY
  • VYEEDMFSD
  • HCSVEQQ
  • GCRCIELDCWDGPDG
  • VLGARHLPK
  • SSHNTYL
  • DYTLSFWR
  • ELSDLVVY
  • VALNFQT
  • EIKEIRPGK

Post-translational modifications for PLCG2 Gene

  • Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCG2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLCG2 (PLCG2)
  • Cloud-Clone Corp. Antibodies for PLCG2

Domains & Families for PLCG2 Gene

Suggested Antigen Peptide Sequences for PLCG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLCG2: view

No data available for UniProtKB/Swiss-Prot for PLCG2 Gene

Function for PLCG2 Gene

Molecular function for PLCG2 Gene

GENATLAS Biochemistry:
phospholipase C,gamma 2,phosphatidylinositol specific,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Enzyme Numbers (IUBMB) for PLCG2 Gene

Gene Ontology (GO) - Molecular Function for PLCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IPI 20624904
GO:0004435 phosphatidylinositol phospholipase C activity IEA,TAS --
GO:0004629 phospholipase C activity TAS --
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 15644415
genes like me logo Genes that share ontologies with PLCG2: view
genes like me logo Genes that share phenotypes with PLCG2: view

Human Phenotype Ontology for PLCG2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLCG2 Gene

MGI Knock Outs for PLCG2:

Animal Model Products

miRNA for PLCG2 Gene

miRTarBase miRNAs that target PLCG2

Inhibitory RNA Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for PLCG2 Gene

Localization for PLCG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCG2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PLCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PLCG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLCG2 Gene

Pathways & Interactions for PLCG2 Gene

genes like me logo Genes that share pathways with PLCG2: view

Pathways by source for PLCG2 Gene

SIGNOR curated interactions for PLCG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002316 follicular B cell differentiation IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006661 phosphatidylinositol biosynthetic process IDA 11606584
genes like me logo Genes that share ontologies with PLCG2: view

Drugs & Compounds for PLCG2 Gene

(17) Drugs for PLCG2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
calcium Nutra 0

(403) Additional Compounds for PLCG2 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)

(2) Tocris Compounds for PLCG2 Gene

Compound Action Cas Number
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCG2: view

Transcripts for PLCG2 Gene

Unigene Clusters for PLCG2 Gene

Phospholipase C, gamma 2 (phosphatidylinositol-specific):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCG2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6:
SP7:
SP8:

ExUns: 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b ^ 34
SP1: - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PLCG2 Gene

GeneLoc Exon Structure for
PLCG2
ECgene alternative splicing isoforms for
PLCG2

Expression for PLCG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLCG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PL