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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLCG2 Gene

protein-coding GIFtS: 70
GCID: GC16P081773

phospholipase C, gamma 2 (phosphatidylinositol-specific)

Explore 35 diseases affiliated with
PLCG2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase C, Gamma 2 (Phosphatidylinositol-Specific)¹ ²		EC 3.1.4.11³ ⁸
Phosphoinositide Phospholipase C-Gamma-2² ³		1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2²
Phospholipase C-IV² ³		APLAID²
PLC-IV² ³		FCAS3²
PLC-Gamma-2¹		Phospholipase C-Gamma-2³

External Ids:	HGNC: 9066¹	Entrez Gene: 5336²	Ensembl: ENSG00000197943⁷	OMIM: 600220⁵	UniProtKB: P16885³

Export aliases for PLCG2 gene to outside databases

Previous GC identifers: GC16P072654 GC16P082773 GC16P081551 GC16P081593 GC16P081569 GC16P080370 GC16P081812 GC16P067566

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLCG2:

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG),

using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth

factor receptors and immune system receptors across the cell membrane. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: PLCG2_HUMAN, P16885

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in

transmembrane signaling

summary for PLCG2:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the

hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and

1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily

activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth

factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological

functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane

phospholipids.

Gene Wiki entry for PLCG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLCG2 gene promoter:
AP-1 ATF-2 Lmo2 Olf-1 NF-kappaB FOXL1 CRE-BP1 Sox9 NF-kappaB1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLCG2 promoter sequence

Search SABiosciences Chromatin IP Primers for PLCG2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCG2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1 Ensembl cytogenetic band: 16q23.3 HGNC cytogenetic band: 16q24.1

PLCG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCG2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P081773: view genomic region (about GC identifiers)

Start:	81,772,702 bp from pter	End:	81,991,899 bp from pter
Size:	219,198 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLCG2_HUMAN, P16885 (See protein sequence)

Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Size: 1265 amino acids; 147870 Da

Cofactor: Calcium

Subunit: Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity)

Sequence caution: Sequence=AAA60112.1; Type=Frameshift; Positions=1242; Sequence=AAQ76815.1; Type=Frameshift;

Positions=1242; Sequence=BAD92151.1; Type=Erroneous initiation; Sequence=CAA32194.1; Type=Frameshift; Positions=1242;

3 PDB 3D structures from and Proteopedia for PLCG2:

2K2J (3D)

2W2W (3D)

2W2X (3D)

Secondary accessions: D3DUL3 Q3ZTS2 Q59H45 Q969T5

Explore the universe of human proteins at neXtProt for PLCG2: NX_P16885

Post-translational modifications:

Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon

ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads

to increased phospholipase activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P16885

4/10 DME Specific Peptides for PLCG2 (P16885) (see all 10)

RVDSSNY

VALNFQT

HCSVEQQ

SSHNTYL

PLCG2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002652.2

ENSEMBL proteins:

ENSP00000455956 ENSP00000352336 ENSP00000455533 ENSP00000454536

Reactome Protein details: P16885
Human Recombinant Protein Products:

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	Novus Biologicals PLCG2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--

PLCG2 for ontologies About GeneDecksing

PLCG2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for PLCG2 (PLC-gamma 2)
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	GenScript Custom Superior Antibodies Services for PLCG2
	Novus Biologicals PLCG2 Antibodies
	Abcam antibodies for PLCG2
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	ThermoFisher Antibodies for PLCG2

Assay Products for PLCG2:

	EMD Millipore Kits and Assays for the Analysis of PLCG2
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PLCG2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLCG2 for domains About GeneDecksing

5/13 InterPro domains/families (see all 13):

IPR015359 PLipase_C_EF-hand-like

IPR001192 Pinositol_PLipase_C

IPR001849 Pleckstrin_homology

IPR001452 SH3_domain

IPR018029 C2_membr_targeting

Graphical View of Domain Structure for InterPro Entry P16885

ProtoNet protein and cluster: P16885

5 Blocks protein families:

IPB000008 C2 domain

IPB000909 Phosphatidylinositol-specific phospholipase C

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: PLCG2_HUMAN, P16885

Similarity: Contains 1 C2 domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 PI-PLC X-box domain

Similarity: Contains 1 PI-PLC Y-box domain

Similarity: Contains 2 SH2 domains

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PLCG2_HUMAN, P16885

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in

transmembrane signaling

Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate +

diacylglycerol

Genatlas biochemistry entry for PLCG2:

phospholipase C,gamma 2,phosphatidylinositol specific,involved in signal transduction

Enzyme Number (IUBMB): EC 3.1.4.11¹ ²

miRNA Products:		OriGene 3'-UTR Clone: PLCG2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCG2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate PLCG2:
		hsa-miR-3658
		SwitchGear 3'UTR luciferase reporter plasmid: PLCG2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLCG2 (see all 7) OriGene shRNA RFP: PLCG2 OriGene siRNA: PLCG2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCG2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PLCG2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLCG2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLCG2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLCG2 (NM_002661)
		Browse Sino Biological Human cDNA Clones
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCG2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PLCG2
		Search LifeMap BioReagents cell lines for PLCG2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCG2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphatidylinositol phospholipase C activity	IDA	12181444
GO:0004629	phospholipase C activity	TAS	--
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IPI	15644415
GO:0005543	phospholipid binding	IEA	--

PLCG2 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for PLCG2:

Decreased focal adhesion (FA)

G0/1 arrest

Increased G1 DNA content

Increased cell size

Animal Models:
Mouse knock-out Plcg2^tm1Jni for PLCG2
12 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Plcg2):

cardiovascular system	cellular	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	limbs/digits/tail	mortality/aging	renal/urinary system
skeleton	tumorigenesis

PLCG2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/83 super-pathways (see all 83) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

ErbB4 Pathway

8/10 pathways (see all 10)
ErbB Family Pathway	0.59	LPS Stimulated MAPK Signaling	0.36
Prolactin Signaling	0.54	VEGF Signaling Pathway	0.35
ErbB2-ErbB3 Heterodimers	0.47	TREM1 Pathway	0.32
IL-2 Pathway	0.46	Growth Hormone Signaling	0.32

VEGF Family Ligands and Receptor Interactions

	VEGF Family Ligands and Receptor Interactions	1.00			Development_VEGF-family signaling	0.36
	VEGF Pathway	0.66			Development VEGF-family signaling	0.36

Immune response CD16 signaling in NK cells

	Immune response CD16 signaling in NK cells	1.00			Immune response_Role of DAP12 receptors in NK cells	0.32
	Immune response_CD16 signaling in NK cells	0.99			Immune response Role of DAP12 receptors in NK cells	0.32

Sweet Taste Signaling

	Sweet Taste Signaling	1.00			Cellular Effects of Sildenafil	0.46
	Melatonin Signaling	0.72			Sperm Motility	0.36

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 EMD Millipore Pathways for PLCG2 (see all 15)

	Transcription Transcription factor Tubby signaling pathways
	Immune response CD16 signaling in NK cells
	Immune response Role of DAP12 receptors in NK cells
	Development GDNF family signaling
	G-protein signaling G-Protein alpha-12 signaling pathway

5/77 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLCG2 (see all 77)

	Fc-GammaR Pathway
	Intracellular Calcium Signaling
	UVA-Induced MAPK Signaling
	PACAP Signaling
	ErbB Family Pathway

2 Cell Signaling Technology (CST) Pathways for PLCG2

	Ca, cAMP and Lipid Signaling
	Lymphocyte Signaling

5/15 GeneGo (Thomson Reuters) Pathways for PLCG2 (see all 15)

	Anandamide biosynthesis and metabolism
	Development EPO-induced MAPK pathway
	Immune response CD16 signaling in NK cells
	Immune response BCR pathway
	G-protein signaling G-Protein alpha-12 signaling pathway

5/11 BioSystems Pathways for PLCG2 (see all 11)

	Signaling Pathways in Glioblastoma
	EGFR1 Signaling Pathway
	Myometrial Relaxation and Contraction Pathways
	D-myo-inositol-5-phosphate metabolism
	B Cell Receptor Signaling Pathway

5/18 Reactome Pathways for PLCG2 (see all 18)

	Metabolism
	Inositol phosphate metabolism
	DAP12 interactions
	DAP12 signaling
	Role of phospholipids in phagocytosis

4 PharmGKB Pathways for PLCG2

	EGFR Inhibitor Pathway, Pharmacodynamics
	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
	Proton Pump Inhibitor Pathway, Pharmacodynamics
	VEGF Signaling Pathway

5/18 Kegg Pathways (Kegg details for PLCG2) (see all 18):

	Inositol phosphate metabolism
	Metabolic pathways
	ErbB signaling pathway
	Calcium signaling pathway
	Phosphatidylinositol signaling system

PLCG2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PLCG2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/209 Interacting proteins for PLCG2 (P16885^{1, 2, 3} ENSP00000352336⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 209)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB2	P04626²^,³, ENSP00000269571⁴	MINT-74684 MINT-74686 I2D: score=2 STRING: ENSP00000269571
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-8112159 I2D: score=3 STRING: ENSP00000274335
MED28	Q9H204²^,³, ENSP00000237380⁴	MINT-7041747 I2D: score=1 STRING: ENSP00000237380
ZNF512B	Q96KM6²^,³	MINT-60791 I2D: score=2
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-74685 MINT-74683 I2D: score=2 STRING: ENSP00000275493

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002316	follicular B cell differentiation	IEA	--
GO:0006661	phosphatidylinositol biosynthetic process	IDA	12181444
GO:0007204	elevation of cytosolic calcium ion concentration	--	--
GO:0007596	blood coagulation	TAS	--
GO:0009395	phospholipid catabolic process	IEA	--

PLCG2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PLCG2 for compounds About GeneDecksing

EMD Millipore small molecules for PLCG2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLCG2 available from Tocris Bioscience About this table

Compound	Action	CAS #
U 73343	Inactive analog of U 73122 (Cat. No. 1268)	[142878-12-4]
m-3M3FBS	Phospholipase C activator	[200933-14-8]
U 73122	Phospholipase C inhibitor	[112648-68-7]
Edelfosine	Selective PI-PLC inhibitor, also PAF receptor agonist	[77286-66-9]

10/1226 HMDB Compounds for PLCG2 (see all 1226) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
1-Phosphatidyl-D-myo-inositol	1-Phosphatidyl-1D-myo-inositol (see all 6)	--	--
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--

10/33 Novoseek chemical compound relationships for PLCG2 gene (see all 33) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
convulxin	88.9	13	10217417 (3), 9637734 (2), 9670039 (2), 16198316 (1) (see all 6)
tyrosine	80.4	282	12181444 (7), 10348703 (6), 7862136 (5), 14656219 (4) (see all 99)
phosphatidylinositol-3,4,5-trisphosphate	71.5	3	16172125 (1), 11071639 (1), 16115811 (1)
inositol 1,4,5 trisphosphate	65.3	9	15474558 (1), 17229422 (1), 15184383 (1), 11389024 (1) (see all 9)
piceatannol	64.8	4	8900143 (2), 11344169 (1), 17063483 (1)
phosphoinositide	62.9	6	12023895 (1), 7517665 (1), 11339363 (1), 18313326 (1)
phosphatidylinositol	62.8	27	7507510 (2), 12215216 (2), 8395016 (2), 12504103 (2) (see all 13)
thromboxane a2	59.8	2	17063483 (2)
wortmannin	54.7	9	9450969 (2), 10432314 (1), 10217417 (1), 9733717 (1) (see all 7)
calcium	54.4	69	12970180 (5), 1499719 (4), 11434777 (3), 15474558 (2) (see all 32)

Search CenterWatch for drugs/clinical trials and news about PLCG2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLCG2 gene:

NM_002661.3

Unigene Cluster for PLCG2:

Phospholipase C, gamma 2 (phosphatidylinositol-specific)

Hs.413111 [show with all ESTs]

Unigene Representative Sequence: NM_002661

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000565054 ENST00000359376(uc002fgt.3) ENST00000569929 ENST00000567980(uc010chg.1)

ENST00000565400 ENST00000569523 ENST00000565020 ENST00000563193 ENST00000562605

ENST00000563375 ENST00000570198 ENST00000570196 ENST00000563269 ENST00000567373

ENST00000563834 ENST00000567356

miRNA Products:		OriGene 3'-UTR Clone: PLCG2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCG2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate PLCG2:
		hsa-miR-3658
		SwitchGear 3'UTR luciferase reporter plasmid: PLCG2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLCG2 (see all 7) OriGene shRNA RFP: PLCG2 OriGene siRNA: PLCG2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCG2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLCG2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLCG2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLCG2 (NM_002661)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCG2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCG2

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PLCG2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLCG2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCG2

Additional cDNA sequence:

AB208914.1 AK304722.1 AK310042.1 AY364256.1 BC007565.1 BC011772.2 BC014561.2 BC018646.2

M37238.1 X14034.1

9 DOTS entries:

DT.413573 DT.100757376 DT.100757372 DT.40132617 DT.97842900 DT.100738986 DT.120661917 DT.40248859

DT.86995022

24/184 AceView cDNA sequences (see all 184):

BG391985 BQ049718 BQ058829 BF901674 BM989096 CA407891 BQ883965 T28753

AW835206 AW835220 AA744504 AW835208 AA360675 AW576414 AU157364 AW575652

BX105088 AW015904 AW835209 CA439295 BM773235 BM564033 BQ217070 BM478107

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PLCG2 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^
SP1:					-																		-								-				-
SP2:					-						-
SP3:																							-								-
SP4:
SP5:																																			-

ExUns:	22	^	23a	·	23b	^	24	^	25a	·	25b	^	26a	·	26b	^	27	^	28a	·	28b	^	29	^	30a	·	30b	^	31	^	32	^	33a	·	33b	^	34
SP1:			-								-		-												-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PLCG2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLCG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCAAACCT

About this image

PLCG2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Definitive endoderm-like cells (A scalable, suspensi...)

See PLCG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLCG2

SOURCE GeneReport for Unigene cluster: Hs.413111

SABiosciences Expression via Pathway-Focused PCR Arrays including PLCG2:

Hypertension in human mouse rat

VEGF Signaling in human mouse rat

Antifungal Response in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCG2 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLCG2¹	phospholipase C, gamma 2 (phosphatidylinositol-specific)	75.13(n) 83.17(a)		415805 XM_414166.3 XP_414166.3
lizard (Anolis carolinensis)	Reptilia	PLCG2⁶	--	80(a)	1 ↔ 1	LGc(6057436-6100308)
zebrafish (Danio rerio)	Actinopterygii	plcg2¹	phospholipase C, gamma 2	63.89(n) 60.92(a)		561747 NM_001044968.1 NP_001038433.1
fruit fly (Drosophila melanogaster)	Insecta	sl³	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase	37(a)		--
worm (Caenorhabditis elegans)	Secernentea	T01E8.3³	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase	35(a)		II(10222786-10228975) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ATPLC1⁶ ATPLC1⁶ (see all 9)	phosphoinositide phospholipase C 3 (see all 9)	25(a) 25(a) (see all 9)	many ↔ many many ↔ many (see all 9)	5(23704231-23706800) 4(18020674-18022985)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	phospholipase C, putative, expressed (see all 4)	28(a) 24(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(10024184-10026867) 7(29544833-29547989)

ENSEMBL Gene Tree for PLCG2 (if available)
TreeFam Gene Tree for PLCG2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PLCG2 gene

PLCD4² PLCD1² PLCG1² PLCB2² PLCZ1² PLCH1² PLCB3² PLCD3²

PLCB1² PLCB4² PLCH2² PLCL1² PLCL2²

5 SIMAP similar genes for PLCG2 using alignment to 4 protein entries: PLCG2_HUMAN (see all proteins):

PLCG1 PLCG1 variant protein PLCZ1 DKFZp434N101 ARHGEF7

PLCG2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7194672^1,2	C,F,	--	67564809(+)	`TATATA/GTGACT`	1	--	us2k¹ tfbs³		1		WA	118
rs75693931^1,2		--	67565124(+)	`AGTCAC/GAAACG`	1	--	us2k¹		0	--	--	--	--
rs113211084^1,2	C,	--	67566080(+)	`AATTGT/CCTGGG`	1	--	us2k¹		2		CSA WA	120
rs76594819^1,2	F,	--	67566131(+)	`GATCAC/GGTTTT`	1	--	us2k¹		1		NA	120
rs5818351^1,2	C,	--	67566297(+)	`TAAttTTTA/- tttat`	1	--	us2k¹ tfbs³		1		CSA	2
rs62046429^1,2		--	67566936(+)	`CAGGCA/GGGGCG`	1	--	int¹		3		NA WA EA	240
rs62046430^1,2	C,	--	67566973(+)	`CGGCTC/TCCAGG`	1	--	int¹		4		NA EA	244
rs79341966^1,2	C,	--	67567382(+)	`TTCCCG/CGAGAC`	1	--	int¹		2		NA	122
rs4073313^1,2	C,A,	--	67567589(-)	`CAAGAG/CAGCCC`	1	--	int¹		4		WA NA EA	360
rs77214275^1,2		--	67567684(+)	`TGCCCA/GTCGGA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLCG2 (81772702 - 81991899 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for PLCG2
4 CNVs: 67062 37696 72632 77440
3 Indels: 88248 25690 77439
Human Gene Mutation Database (HGMD): PLCG2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PLCG2 for disorders About GeneDecksing

OMIM gene information: 600220 OMIM disorders: --

UniProtKB/Swiss-Prot: PLCG2_HUMAN, P16885

Defects in PLCG2 are the cause of familial cold autoinflammatory syndrome type 3 (FCAS3) [MIM:614468]. An

autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritis in

response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody

deficiency, decreased numbers of B cells, defective B cells, increased susceptibility to infection, and increased risk

of autoimmune disorders

20/35 diseases for PLCG2 (see all 35): About MalaCards

diffuse large b-cell lymphoma b-cell lymphomas retinal vein occlusion wegener's granulomatosis

agammaglobulinemia systemic lupus erythematosus lupus erythematosus acute lymphoblastic leukemia

chronic lymphocytic leukemia lymphoblastic leukemia lymphocytic leukemia wilms tumor

bipolar disorder mediastinitis urticaria neurologic diseases

thrombocytopenia leukemia cholera thrombosis

1 disease from the University of Copenhagen DISEASES database for PLCG2:

Birt-Hogg-Dube syndrome

7 Novoseek disease relationships for PLCG2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
x-linked agammaglobulinemia	51.9	1	17239630 (1)
lymphoma b-cell	31	3	9575194 (1), 9865907 (1)
lymphoma	11.9	3	18596745 (1)
inflammation	0	3	15703080 (1), 15845450 (1)
autoimmunity	0	1	15845450 (1)
tumors	0	1	12881301 (1)
immunodeficiency	0	1	17239630 (1)

Human Genome Epidemiology (HuGE) Navigator: PLCG2 (7 documents)

Export disorders for PLCG2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PLCG2 gene, integrated from 9 sources (see all 261):
(articles sorted by number of sources associating them with PLCG2)

Utopia: connect your pdf to the dynamic
world of online information

Activation of phospholipase Cgamma2 by tyrosine phosphorylation. (PubMed id 12181444)^{1, 2, 9} Ozdener F.... Daniel J.L. (2002)
Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. (PubMed id 11606584)^{1, 2, 9} Rodriguez R....Katan M. (2001)
Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse. (PubMed id 7835906)^{1, 3, 9} Hernandez D....Fisher E.M. (1994)
Cold urticaria, immunodeficiency, and autoimmunity re lated to PLCG2 deletions. (PubMed id 22236196)^{1, 2} Ombrello M.J....Milner J.D. (2012)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes. (PubMed id 2849563)^{1, 2} Ohta S.... Kagawa Y. (1988)
Roles of PLC-gamma2 and PKCalpha in TPA-induced apoptosis of gastric cancer cells. (PubMed id 14606067)^{1, 9} Zhang B....Chen M.C. (2003)
Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets. (PubMed id 10469124)^{1, 9} Gross B.S....Watson S.P. (1999)
Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases. (PubMed id 16172125)^{1, 9} Piechulek T....Gierschik P. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5336	HGNC: 9066	AceView: PLCG2	Ensembl:ENSG00000197943	euGenes: HUgn5336
ECgene: PLCG2	Kegg: 5336	H-InvDB: PLCG2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PLCG2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PLCG2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PLCG2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PLCG2 gene:
Search GeneIP for patents involving PLCG2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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PLCG2 Gene

phospholipase C, gamma 2 (phosphatidylinositol-specific)

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PLCG2 Gene

phospholipase C, gamma 2 (phosphatidylinositol-specific)

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