Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PLCG2 Gene

protein-coding   GIFtS: 72
GCID: GC16P081773

Phospholipase C, Gamma 2 (Phosphatidylinositol-Specific)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phospholipase C, Gamma 2 (Phosphatidylinositol-Specific)1 2     EC 3.1.4.113 8
Phosphoinositide Phospholipase C-Gamma-22 3     APLAID2 5
Phospholipase C-IV2 3     FCAS32 5
PLC-IV2 3     1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-22
PLC-gamma-22 3     Phospholipase C-Gamma-23

External Ids:    HGNC: 90661   Entrez Gene: 53362   Ensembl: ENSG000001979437   OMIM: 6002205   UniProtKB: P168853   

Export aliases for PLCG2 gene to outside databases

Previous GC identifers: GC16P072654 GC16P082773 GC16P081551 GC16P081593 GC16P081569 GC16P080370 GC16P081812 GC16P067566


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PLCG2 Gene:
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol
(DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals
from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have
been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold
autoinflammatory syndrome 3. (provided by RefSeq, Mar 2014)

GeneCards Summary for PLCG2 Gene:
PLCG2 (phospholipase C, gamma 2 (phosphatidylinositol-specific)) is a protein-coding gene. Diseases associated with PLCG2 include familial cold autoinflammatory syndrome 3, and autoinflammation, antibody deficiency, and immune dysregulation syndrome. GO annotations related to this gene include phospholipid binding and phosphatidylinositol phospholipase C activity. An important paralog of this gene is PLCG1.

UniProtKB/Swiss-Prot: PLCG2_HUMAN, P16885
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
(IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in
transmembrane signaling

summary for PLCG2 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLCG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLCG2 gene promoter:
         AP-1   ATF-2   Lmo2   Olf-1   NF-kappaB   FOXL1   CRE-BP1   Sox9   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCG2 promoter sequence
   Search Chromatin IP Primers for PLCG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q23.3   HGNC cytogenetic band: 16q24.1

PLCG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCG2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P081773:  view genomic region     (about GC identifiers)

Start:
81,772,702 bp from pter      End:
81,991,899 bp from pter
Size:
219,198 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PLCG2_HUMAN, P16885 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2  
Size: 1265 amino acids; 147870 Da
Cofactor: Calcium
Subunit: Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity)
Sequence caution: Sequence=AAA60112.1; Type=Frameshift; Positions=1242; Sequence=AAQ76815.1; Type=Frameshift;
Positions=1242; Sequence=BAD92151.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAA32194.1; Type=Frameshift; Positions=1242;
3 PDB 3D structures from and Proteopedia for PLCG2:
2K2J (3D)        2W2W (3D)        2W2X (3D)    
Secondary accessions: D3DUL3 Q3ZTS2 Q59H45 Q969T5

Explore the universe of human proteins at neXtProt for PLCG2: NX_P16885

Explore proteomics data for PLCG2 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK;
    upon ligand-induced activation of a variety of growth factor receptors and immune system receptors.
    Phosphorylation leads to increased phospholipase activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PLCG2 (P16885) (see all 10)
     RVDSSNY  VALNFQT  HCSVEQQ  SSHNTYL 


    See PLCG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002652.2  
    ENSEMBL proteins: 
     ENSP00000455956   ENSP00000352336   ENSP00000455533   ENSP00000454536  
    Reactome Protein details: P16885

    PLCG2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PLCG2
    OriGene Protein Over-expression Lysate for PLCG2
    OriGene MassSpec for PLCG2
    OriGene Custom Protein Services for PLCG2
    GenScript Custom Purified and Recombinant Proteins Services for PLCG2
    Novus Biologicals PLCG2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PLCG2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PLCG2 (PLC-gamma 2)
    Cell Signaling Technology (CST) Antibodies for PLCG2 
    OriGene Antibodies for PLCG2
    OriGene Custom Antibody Services for PLCG2
    Novus Biologicals PLCG2 Antibodies
    Abcam antibodies for PLCG2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PLCG2
    LSBio Antibodies in human, mouse, rat for PLCG2

    PLCG2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PLCG2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PLCG2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: PLCgamma2
    Phosphoinositide-specific phospholipase C

    Selected InterPro protein domains (see all 12):
     IPR015359 PLipase_C_EF-hand-like
     IPR001192 PI-PLC_fam
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry P16885

    ProtoNet protein and cluster: P16885

    5 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PLCG2_HUMAN, P16885
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain
    Similarity: Contains 2 SH2 domains
    Similarity: Contains 1 SH3 domain


    PLCG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCG2_HUMAN, P16885
    Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
    (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in
    transmembrane signaling
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
    + diacylglycerol

         Genatlas biochemistry entry for PLCG2:
    phospholipase C,gamma 2,phosphatidylinositol specific,involved in signal transduction

         Enzyme Number (IUBMB): EC 3.1.4.111 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS--
    GO:0004629phospholipase C activity TAS--
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI15644415
    GO:0008081phosphoric diester hydrolase activity ----
         
    PLCG2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PLCG2:
     Decreased focal adhesion (FA)   G0/1 arrest  Increased G1 DNA content  Increased cell size 

         12 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Plcg2):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  renal/urinary system 
     skeleton  tumorigenesis 

    PLCG2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Plcg2tm1Jni for PLCG2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLCG2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLCG2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLCG2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLCG2

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLCG2:
    hsa-mir-335-5p (MIRT019144)

    Block miRNA regulation of human, mouse, rat PLCG2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PLCG2:
    hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidPLCG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLCG2
    Predesigned siRNA for gene silencing in human, mouse, rat PLCG2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLCG2

    Clone
    Products:
         
    OriGene clones in human, mouse for PLCG2 (see all 7)
    OriGene ORF clones in mouse, rat for PLCG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLCG2 (NM_002661)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCG2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLCG2
    Browse ESI BIO Cell Lines and PureStem Progenitors for PLCG2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    extracellular2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0070062extracellular vesicular exosome IDA--

    PLCG2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PLCG2 About   (see all 90)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    2Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.36
    Phosphatidylinositol signaling system0.61
    D-myo-inositol-5-phosphate metabolism0.00
    superpathway of inositol phosphate compounds0.60
    3VEGF Pathway
    VEGF Family Ligands and Receptor Interactions0.66
    Development VEGF family signaling0.36
    VEGF Pathway0.66
    4Glioma
    Glioma0.51
    Signaling Pathways in Glioblastoma0.36
    Non-small cell lung cancer0.51
    5Development EGFR signaling pathway
    Development GDNF family signaling0.45
    BDNF Pathway0.39
    GDNF-Family Ligands and Receptor Interactions0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for PLCG2
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLCG2 (see all 77)
        Fc-GammaR Pathway
    Intracellular Calcium Signaling
    UVA-Induced MAPK Signaling
    PACAP Signaling
    ErbB Family Pathway

    2 Cell Signaling Technology (CST) Pathways for PLCG2
        Ca, cAMP and Lipid Signaling
    Lymphocyte Signaling

    Selected GeneGo (Thomson Reuters) Pathways for PLCG2 (see all 15)
        Anandamide biosynthesis and metabolism
    Development EPO-induced MAPK pathway
    Immune response CD16 signaling in NK cells
    Immune response BCR pathway
    G-protein signaling G-Protein alpha-12 signaling pathway

    Selected BioSystems Pathways for PLCG2 (see all 12)
        Myometrial Relaxation and Contraction Pathways
    EGFR1 Signaling Pathway
    Signaling Pathways in Glioblastoma
    B Cell Receptor Signaling Pathway
    D-myo-inositol-5-phosphate metabolism

    Selected Reactome Pathways for PLCG2 (see all 8)
        FCERI mediated MAPK activation
    Toll Like Receptor 4 (TLR4) Cascade
    GPVI-mediated activation cascade
    Synthesis of IP3 and IP4 in the cytosol
    DAP12 signaling

    4 PharmGKB Pathways for PLCG2
        EGFR Inhibitor Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for PLCG2) (see all 26):
        Inositol phosphate metabolism
    Metabolic pathways
    ErbB signaling pathway
    Ras signaling pathway
    Calcium signaling pathway


    PLCG2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLCG2: 
              Hypertension in human mouse rat
              VEGF Signaling in human mouse rat
              Antifungal Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLCG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLCG2 (P168851, 2, 3 ENSP000003523364) via UniProtKB, MINT, STRING, and/or I2D (see all 225)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-617403,EBI-641062 MINT-74684 MINT-74686 I2D: score=2 STRING: ENSP00000269571
    PIK3R1P279862, 3, ENSP000002743354MINT-8112159 I2D: score=3 STRING: ENSP00000274335
    MED28Q9H2042, 3, ENSP000002373804MINT-7041747 I2D: score=1 STRING: ENSP00000237380
    ENSG00000215641P143733I2D: score=2 
    ENSG00000229006P143733I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002316follicular B cell differentiation IEA--
    GO:0006629lipid metabolic process ----
    GO:0006661phosphatidylinositol biosynthetic process IDA11606584
    GO:0007165signal transduction ----
    GO:0007596blood coagulation TAS--

    PLCG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PLCG2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLCG2 (see all 1226)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    Selected Novoseek inferred chemical compound relationships for PLCG2 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    convulxin 88.9 13 10217417 (3), 9637734 (2), 9670039 (2), 16198316 (1) (see all 6)
    tyrosine 80.4 282 12181444 (7), 10348703 (6), 7862136 (5), 14656219 (4) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 71.5 3 16172125 (1), 11071639 (1), 16115811 (1)
    inositol 1,4,5 trisphosphate 65.3 9 15474558 (1), 17229422 (1), 15184383 (1), 11389024 (1) (see all 9)
    piceatannol 64.8 4 8900143 (2), 11344169 (1), 17063483 (1)
    phosphoinositide 62.9 6 12023895 (1), 7517665 (1), 11339363 (1), 18313326 (1)
    phosphatidylinositol 62.8 27 7507510 (2), 12215216 (2), 8395016 (2), 12504103 (2) (see all 13)
    thromboxane a2 59.8 2 17063483 (2)
    wortmannin 54.7 9 9450969 (2), 10432314 (1), 10217417 (1), 9733717 (1) (see all 7)
    calcium 54.4 69 12970180 (5), 1499719 (4), 11434777 (3), 15474558 (2) (see all 32)



    PLCG2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PLCG2 gene: 
    NM_002661.4  

    Unigene Cluster for PLCG2:

    Phospholipase C, gamma 2 (phosphatidylinositol-specific)
    Hs.413111  [show with all ESTs]
    Unigene Representative Sequence: NM_002661
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565054 ENST00000359376(uc002fgt.3) ENST00000569929 ENST00000567980(uc010chg.1)
    ENST00000565400 ENST00000569523 ENST00000565020 ENST00000563193 ENST00000562605
    ENST00000563375 ENST00000570198 ENST00000570196 ENST00000563269 ENST00000567373
    ENST00000563834 ENST00000567356
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PLCG2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PLCG2:
    hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidPLCG2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PLCG2
    Predesigned siRNA for gene silencing in human, mouse, rat PLCG2
    Clone
    Products:
         
    OriGene clones in human, mouse for PLCG2 (see all 7)
    OriGene ORF clones in mouse, rat for PLCG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLCG2 (NM_002661)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCG2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PLCG2
    OriGene qSTAR qPCR primer pairs in human, mouse for PLCG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCG2
      QuantiTect SYBR Green Assays in human, mouse, rat PLCG2
      QuantiFast Probe-based Assays in human, mouse, rat PLCG2

    Additional mRNA sequence: 

    AB208914.1 AK304722.1 AK310042.1 AY364256.1 BC007565.1 BC011772.2 BC014561.2 BC018646.2 
    M37238.1 X14034.1 

    9 DOTS entries:

    DT.413573  DT.100757376  DT.100757372  DT.40132617  DT.97842900  DT.100738986  DT.120661917  DT.40248859 
    DT.86995022 

    Selected AceView cDNA sequences (see all 184):

    AW575652 CA435854 AW015904 BF901674 BQ058829 AA744504 CA439295 AW835209 
    T28753 BX105088 AW835208 CA407891 AW576414 BQ217070 AW835206 BQ883965 
    BM564033 BM989096 AA360675 BG391985 D54660 AW835220 BM478107 AU157364 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLCG2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:              -                                                     -                       -           -                                                   
    SP2:              -                 -                                                                                                                           
    SP3:                                                                    -                       -                                                               
    SP4:                                                                                                                                                            
    SP5:                                                                                                        -                                                   

    ExUns: 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b ^ 34
    SP1:        -                       -     -                                   -                                       
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for PLCG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PLCG2 expression in normal human tissues (normalized intensities)      PLCG2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCAAACCT
    PLCG2 Expression
    About this image


    PLCG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    PLCG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLCG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413111
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLCG2: 
              Hypertension in human mouse rat
              VEGF Signaling in human mouse rat
              Antifungal Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PLCG2
    OriGene qSTAR qPCR primer pairs in human, mouse for PLCG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCG2
    QuantiTect SYBR Green Assays in human, mouse, rat PLCG2
    QuantiFast Probe-based Assays in human, mouse, rat PLCG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PLCG2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcg21 , 5 phospholipase C, gamma 21, 5 86.56(n)1
    94.15(a)1
      8 (64.26 cM)5
    2347791  NM_172285.11  NP_758489.11 
     1174982915 
    chicken
    (Gallus gallus)
    Aves PLCG21 phospholipase C, gamma 2 (phosphatidylinositol-specific) 75.13(n)
    83.17(a)
      415805  XM_004944257.1  XP_004944314.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLCG26
    phospholipase C, gamma 2 (phosphatidylinositol-spe...
    80(a)
    1 ↔ 1
    LGc(6047640-6104245)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia plcg21 phospholipase C, gamma 2 (phosphatidylinositol-specific) 67.66(n)
    70.49(a)
      100496686  XM_002934948.2  XP_002934994.2 
    zebrafish
    (Danio rerio)
    Actinopterygii plcg21 phospholipase C, gamma 2 63.99(n)
    61.29(a)
      561747  NM_001044968.1  NP_001038433.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sl3
    1-phosphatidylinositol-4,5-bisphosphate
    phosphodiesterase
    37(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea T01E8.33 1-phosphatidylinositol-4,5-bisphosphate
    phosphodiesterase
    35(a)   II(10222786-10228975)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PLC16
    Phospholipase C, hydrolyzes phosphatidylinositol 4...
    24(a)
    1 → many
    XVI(35236-37845) YPL268W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PLC51 PLC5 47.28(n)
    35.62(a)
      835983  NM_125256.2  NP_200677.2 


    ENSEMBL Gene Tree for PLCG2 (if available)
    TreeFam Gene Tree for PLCG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PLCG2 gene
    PLCG12  PLCE12  
    6 SIMAP similar genes for PLCG2 using alignment to 4 protein entries:     PLCG2_HUMAN (see all proteins):
    PLCG1    PLCG1 variant protein    PLCZ1    DKFZp434N101    PLCH2    ARHGEF7

    PLCG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PLCG2 (see all 6465)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692114
    Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated (APLAID)4--see VAR_0692112 S Y mis40--------
    rs756939311,2
    --67565124(+) AGTCAC/GAAACG 1 -- us2k10--------
    rs351310991,2
    C--67566298(+) AATTT-/TTTA  
            
    TTATT
    1 -- us2k10--------
    rs1120073431,2
    C--67568509(+) TCAAGACAA/-  
            
    ACAAA
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2008532581,2
    C--67569718(+) AGAAAA/GANNNN 1 -- int10--------
    rs286396081,2
    C,F--67584301(+) AACTGT/GGAGAC 1 -- int13Minor allele frequency- G:0.17NA WA 6
    rs2017913431,2
    --67584301(+) AACTG-/TGAGAC 1 -- int10--------
    rs283762781,2
    C,F--67584302(+) ACTGTG/AAGACA 1 -- int13Minor allele frequency- A:0.17NA WA 6
    rs129330671,2
    H--67589550(+) CAGTCT/CTTTTT 1 -- int1 trp34Minor allele frequency- C:0.00NS EA 372
    rs1443116071,2
    C--67590985(+) TTTCC-/TTTCTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for PLCG2 (81772702 - 81991899 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PLCG2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv989873CNV Deletion20482838
    esv1122914CNV Deletion17803354
    esv2714793CNV Deletion23290073
    esv2714792CNV Deletion23290073
    dgv412e201CNV Deletion23290073
    esv2673687CNV Deletion23128226
    esv2665175CNV Deletion23128226
    esv2678204CNV Deletion23128226
    esv273451CNV Insertion20981092
    esv1008749CNV Insertion20482838

    Human Gene Mutation Database (HGMD): PLCG2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLCG2
    DNA2.0 Custom Variant and Variant Library Synthesis for PLCG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600220   
    OMIM disorders: 614468  614878  
    UniProtKB/Swiss-Prot: PLCG2_HUMAN, P16885
  • Familial cold autoinflammatory syndrome 3 (FCAS3) [MIM:614468]: An autosomal dominant immune disorder
    characterized by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure.
    Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased
    numbers of B cells, defective B cells, increased susceptibility to infection, and increased risk of autoimmune
    disorders. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated (APLAID) [MIM:614878]:
    An autosomal dominant systemic disorder characterized by recurrent blistering skin lesions with a dense
    inflammatory infiltrate and variable involvement of other tissues, including joints, the eye, and the
    gastrointestinal tract. Affected individuals have a mild humoral immune deficiency associated with recurrent
    sinopulmonary infections, but no evidence of circulating autoantibodies. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for PLCG2 (see all 35):    About MalaCards
    familial cold autoinflammatory syndrome 3    autoinflammation, antibody deficiency, and immune dysregulation syndrome    birt-hogg-dube syndrome    agammaglobulinemia
    retinal vein occlusion    mediastinitis    wegener's granulomatosis    urticaria
    neurologic diseases    thrombocytopenia    glioblastoma multiforme    wilms tumor
    b-cell lymphomas    diffuse large b-cell lymphoma    cholera    huntington's disease
    retinitis    influenza    lymphoblastic leukemia    chronic lymphocytic leukemia

    1 disease from the University of Copenhagen DISEASES database for PLCG2:
    Birt-Hogg-Dube syndrome

    PLCG2 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for PLCG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    x-linked agammaglobulinemia 51.9 1 17239630 (1)
    lymphoma b-cell 31 3 9575194 (1), 9865907 (1)
    lymphoma 11.9 3 18596745 (1)
    inflammation 0 3 15703080 (1), 15845450 (1)
    autoimmunity 0 1 15845450 (1)
    tumors 0 1 12881301 (1)
    immunodeficiency 0 1 17239630 (1)

    Genetic Association Database (GAD): PLCG2
    Human Genome Epidemiology (HuGE) Navigator: PLCG2 (7 documents)

    Export disorders for PLCG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PLCG2 gene, integrated from 10 sources (see all 273):
    (articles sorted by number of sources associating them with PLCG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of phospholipase Cgamma2 by tyrosine phosphorylation. (PubMed id 12181444)1, 2, 9 Ozdener F.... Daniel J.L. (Mol. Pharmacol. 2002)
    2. Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. (PubMed id 11606584)1, 2, 9 Rodriguez R.... Katan M. (J. Biol. Chem. 2001)
    3. Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse. (PubMed id 7835906)1, 3, 9 Hernandez D....Fisher E.M. (Genomics 1994)
    4. A hypermorphic missense mutation in PLCG2, encoding phospholipase Cgamma2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. (PubMed id 23000145)1, 2 Zhou Q.... Aksentijevich I. (Am. J. Hum. Genet. 2012)
    5. Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. (PubMed id 22236196)1, 2 Ombrello M.J.... Milner J.D. (N. Engl. J. Med. 2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    8. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PubMed id 19308021)1, 4 Ollila H.M....Paunio T. (Mol. Psychiatry 2009)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)1, 4 Walker L.C....Spurdle A.B. (Breast Cancer Res. Treat. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5336 HGNC: 9066 AceView: PLCG2 Ensembl:ENSG00000197943 euGenes: HUgn5336
    ECgene: PLCG2 Kegg: 5336 H-InvDB: PLCG2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PLCG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLCG2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PLCG2 gene:
    Search GeneIP for patents involving PLCG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for PLCG2 (PLC-gamma 2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PLCG2   OriGene RNAi products in human, mouse, rat for PLCG2  
     OriGene qPCR primer pairs and template standards for PLCG2   OriGene Protein Over-expression Lysate for PLCG2  
     OriGene MassSpec something-or-other for PLCG2   OriGene clones in human, mouse for PLCG2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PLCG2   OriGene Purified Protein for PLCG2  
     OriGene ORF clones in mouse, rat for PLCG2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PLCG2   OriGene Custom Protein Services for PLCG2  

     
     
     Block miRNA regulation of human, mouse, rat PLCG2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PLCG2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCG2 Predesigned siRNA for gene silencing in human, mouse, rat PLCG2
     QuantiFast Probe-based Assays in human, mouse, rat PLCG2 QuantiTect SYBR Green Assays in human, mouse, rat PLCG2
     PCR Arrays including human, mouse, rat PLCG2 Search Chromatin IP Primers for PLCG2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCG2  GeneGlobe Interaction Network for PLCG2
     Regulatory tfbs in PLCG2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PLCG2 GenScript cDNA clones with any tag delivered in your preferred vector for PLCG2
     GenScript Custom Assay Services for PLCG2 GenScript Custom overexpressing Cell Line Services for PLCG2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for PLCG2 

     Tocris compounds for PLCG2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PLCG2 antibodies
     PLCG2 lysates
     Antibodies for PLCG2
     See all of Abcam's Antibodies, Kits and Proteins for PLCG2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PLCG2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCG2
     SwitchGear 3'UTR luciferase reporter plasmids for PLCG2
     SwitchGear Promoter luciferase reporter plasmids for PLCG2
     ThermoFisher Antibody for PLCG2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCG2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLCG2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLCG2
     LSBio Antibodies in human, mouse, rat for PLCG2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PLCG2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4