Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PLCG1 Gene

protein-coding   GIFtS: 71
GCID: GC20P039765

Phospholipase C, Gamma 1

(Previous names: phospholipase C, gamma 1 (formerly subtype 148))
(Previous symbol: PLC1)
  See PLCG1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phospholipase C, Gamma 11 2     1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma 12
PLC11 2 3 5     1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma-12
Phospholipase C, Gamma 1 (Formerly Subtype 148)1 2     NCKAP32
Phosphoinositide Phospholipase C-Gamma-12 3     PLC1482
Phospholipase C-Gamma-12 3     PLCgamma12
Phospholipase C-II2 3     inositoltrisphosphohydrolase2
PLC-1482 3     Monophosphatidylinositol Phosphodiesterase2
PLC-II2 3     Phosphatidylinositol Phospholipase C2
PLC-gamma-12 3     Phosphoinositidase C2
EC 3.1.4.113 8     Phosphoinositide Phospholipase C2
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate2     Phospholipase C-1482
1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-12     Triphosphoinositide Phosphodiesterase2

External Ids:    HGNC: 90651   Entrez Gene: 53352   Ensembl: ENSG000001241817   OMIM: 1724205   UniProtKB: P191743   

Export aliases for PLCG1 gene to outside databases

Previous GC identifers: GC20P039494 GC20P040404 GC20P040451 GC20P039199 GC20P036506


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PLCG1 Gene:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from
phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in
the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by
SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi,
where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth
factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PLCG1 Gene:
PLCG1 (phospholipase C, gamma 1) is a protein-coding gene. Diseases associated with PLCG1 include mycobacterium kansasii. GO annotations related to this gene include receptor signaling protein activity and calcium ion binding. An important paralog of this gene is PLCG2.

UniProtKB/Swiss-Prot: PLCG1_HUMAN, P19174
Function: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol
1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes
activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB,
FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration

summary for PLCG1 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLCG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLCG1 gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PLCG1 promoter sequence
   Search Chromatin IP Primers for PLCG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.1   Ensembl cytogenetic band:  20q12   HGNC cytogenetic band: 20q12-q13.1

PLCG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCG1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P039765:  view genomic region     (about GC identifiers)

Start:
39,765,600 bp from pter      End:
39,811,629 bp from pter
Size:
46,030 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PLCG1_HUMAN, P19174 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1  
Size: 1290 amino acids; 148532 Da
Cofactor: Calcium
Subunit: Interacts with AGAP2 via its SH3 domain. Interacts (via SH2 domain) with RET. Interacts with FLT1
(tyrosine-phosphorylated) (By similarity). Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4
(phosphorylated). Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the
Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent
fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts
(via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively
regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK (By similarity).
Interacts with AXL, FLT4 and KIT. Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein.
Interacts (via the SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites).
Interacts (via SH2 domain) with PDGFRA and PDGFRB (tyrosine phosphorylated). Interacts with PIP5K1C (By
similarity). Interacts with NTRK1 and NTRK2 (phosphorylated upon ligand-binding). Interacts with SYK; activates
PLCG1. Interacts with GRB2, LAT and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with
TESPA1; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the
LAT signalosome
4 PDB 3D structures from and Proteopedia for PLCG1:
1HSQ (3D)        2HSP (3D)        4EY0 (3D)        4FBN (3D)    
Secondary accessions: B7ZLY7 B9EGH4 E1P5W4 Q2V575
Alternative splicing: 2 isoforms:  P19174-1   P19174-2   (Contains a phosphoserine at position 1222)

Explore the universe of human proteins at neXtProt for PLCG1: NX_P19174

Explore proteomics data for PLCG1 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine
    phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR.
    Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its
    phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune
    system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell
    receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in
    T-cells1
  • Ubiquitinated by CBLB in activated T-cells (By similarity)1
  • Ubiquitination2 at Lys178, Lys226, Lys431, Lys440, Lys941
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PLCG1 (P19174) (see all 13)
     QLSRIYP  VALNFQT  YHGHTLT  SSHNTYL 


    See PLCG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002651.2  NP_877963.1  

    ENSEMBL proteins: 
     ENSP00000244007   ENSP00000362368   ENSP00000468958   ENSP00000476432   ENSP00000476757  
     ENSP00000476454   ENSP00000362369  
    Reactome Protein details: P19174

    PLCG1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PLCG1
    OriGene Protein Over-expression Lysate for PLCG1
    OriGene MassSpec for PLCG1
    OriGene Custom Protein Services for PLCG1
    GenScript Custom Purified and Recombinant Proteins Services for PLCG1
    Novus Biologicals PLCG1 Protein
    Novus Biologicals PLCG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PLCG1 

    PLCG1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PLCG1
    R&D Systems Antibodies for PLCG1 (PLC-gamma 1)
    Cell Signaling Technology (CST) Antibodies for PLCG1 
    OriGene Antibodies for PLCG1
    OriGene Custom Antibody Services for PLCG1
    Novus Biologicals PLCG1 Antibodies
    Abcam antibodies for PLCG1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PLCG1
    LSBio Antibodies in human, mouse, rat for PLCG1

    PLCG1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PLCG1
    R&D Systems Proteome Profiler Antibody Arrays for PLCG1 (PLC-gamma 1)
    GenScript Custom Assay Services for PLCG1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PLCG1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing
    EFHAND: EF-hand domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: PLCgamma1
    Phosphoinositide-specific phospholipase C

    Selected InterPro protein domains (see all 15):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR001192 PI-PLC_fam
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry P19174

    ProtoNet protein and cluster: P19174

    5 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PLCG1_HUMAN, P19174
    Domain: The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction
    with RALGPS1
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 2 PH domains
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain
    Similarity: Contains 2 SH2 domains
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with PLCG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCG1_HUMAN, P19174
    Function: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol
    1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes
    activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB,
    FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
    + diacylglycerol
    Enzyme regulation: Activated by phosphorylation on tyrosine residues

         Genatlas biochemistry entry for PLCG1:
    phospholipase C,gamma 1 (subtype 148),phosphatidylinositol specific,involved in signal transduction,directly
    interacting with phosphorylated PTK2 to promote adhesion-dependent association of the two molecules and increase
    inositol-phosphate production (mouse fibroblasts)

         Enzyme Number (IUBMB): EC 3.1.4.111 2

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS--
    GO:0004629phospholipase C activity TAS--
    GO:0004871signal transducer activity ----
    GO:0005057receptor signaling protein activity NAS7681365
    GO:0005168neurotrophin TRKA receptor binding IPI15488758
         
    Find genes that share ontologies with PLCG1           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Plcg1):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size/body 
     hearing/vestibular/ear  hematopoietic system  immune system  integument  mortality/aging 

    Find genes that share phenotypes with PLCG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PLCG1: Plcg1tm1Ine Plcg1tm1Gcrp

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLCG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLCG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLCG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLCG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLCG1:
    hsa-mir-92a-3p (MIRT049488), hsa-mir-744-3p (MIRT037381), hsa-mir-1914-3p (MIRT035779), hsa-mir-34a-5p (MIRT025369)

    Block miRNA regulation of human, mouse, rat PLCG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLCG1 (see all 46):
    hsa-miR-429 hsa-miR-4328 hsa-miR-938 hsa-miR-30d hsa-miR-449a hsa-miR-218 hsa-miR-30a hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidPLCG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLCG1
    Predesigned siRNA for gene silencing in human, mouse, rat PLCG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLCG1

    Clone
    Products:
         
    OriGene clones in human, mouse for PLCG1 (see all 13)
    OriGene ORF clones in mouse, rat for PLCG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLCG1 (NM_182811)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCG1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLCG1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PLCG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PLCG1_HUMAN, P19174: Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to
    ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    plasma membrane5
    cytoskeleton2
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA17229814
    GO:0005737cytoplasm IDA15702972
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0008180COP9 signalosome IDA--

    Find genes that share ontologies with PLCG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PLCG1 About   (see all 125)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    Fc-epsilon receptor I signaling in mast cells0.34
    2ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    3Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.92
    EGFR interacts with phospholipase C-gamma0.94
    Phospholipase C-mediated cascade0.59
    PLC-gamma1 signalling0.94
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    4Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    GDNF-Family Ligands and Receptor Interactions0.41
    Development ERBB family signaling0.57
    EGF Pathway0.39
    Development GDNF family signaling0.45
    BDNF Pathway0.39
    5Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.36
    Phosphatidylinositol signaling system0.61
    D-myo-inositol-5-phosphate metabolism0.00
    superpathway of inositol phosphate compounds0.60


    Find genes that share SuperPaths with PLCG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PLCG1
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLCG1 (see all 86)
        Fc-GammaR Pathway
    Intracellular Calcium Signaling
    UVA-Induced MAPK Signaling
    PACAP Signaling
    ITK and TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for PLCG1
        Ca, cAMP and Lipid Signaling

    Selected GeneGo (Thomson Reuters) Pathways for PLCG1 (see all 32)
        Anandamide biosynthesis and metabolism
    Development FGF-family signaling
    Development EGFR signaling pathway
    Immune response CD28 signaling
    Immune response CD16 signaling in NK cells

    Selected BioSystems Pathways for PLCG1 (see all 41)
        Myometrial Relaxation and Contraction Pathways
    Angiogenesis
    EGFR1 Signaling Pathway
    ErbB signaling pathway
    BDNF signaling pathway

    Selected Reactome Pathways for PLCG1 (see all 20)
        FCERI mediated MAPK activation
    Downstream signal transduction
    DAP12 signaling
    Role of second messengers in netrin-1 signaling
    Role of phospholipids in phagocytosis

    3 PharmGKB Pathways for PLCG1
        EGFR Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for PLCG1) (see all 26):
        Inositol phosphate metabolism
    Metabolic pathways
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLCG1: 
              Hypertension in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Synaptic Plasticity in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLCG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLCG1 (P191741, 2, 3 ENSP000002440074) via UniProtKB, MINT, STRING, and/or I2D (see all 444)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INSRP062131, 2, 3, ENSP000003038304EBI-79387,EBI-475899 MINT-6805867 MINT-6805048 MINT-6805152 MINT-6805846 MINT-6805776 MINT-6805101 MINT-6805266 MINT-6805899 MINT-6805199 I2D: score=2 STRING: ENSP00000303830
    AKT1P317491, 2, 3, ENSP000002702024EBI-79387,EBI-296087 MINT-7146749 MINT-7146647 MINT-7146716 MINT-7146688 MINT-7146767 MINT-7146702 MINT-7146731 MINT-7146657 MINT-7146671 I2D: score=1 STRING: ENSP00000270202
    RAC1P630001, 2, 3, ENSP000003484614EBI-79387,EBI-413628 MINT-7230055 MINT-7229970 MINT-7230002 MINT-7230027 MINT-7229927 MINT-7229937 MINT-7229952 I2D: score=1 STRING: ENSP00000348461
    EGFRP005331, 2, 3, ENSP000002754934EBI-79387,EBI-297353 MINT-74678 MINT-8029276 MINT-6805660 MINT-6805366 MINT-6805629 MINT-8038519 I2D: score=5 STRING: ENSP00000275493
    SYKP434051, 2, 3, ENSP000003648984EBI-79387,EBI-78302 MINT-8035261 MINT-7301369 MINT-8028953 MINT-8028938 MINT-8035276 I2D: score=6 STRING: ENSP00000364898
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity TAS--
    GO:0001701in utero embryonic development IEA--
    GO:0006629lipid metabolic process ----
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with PLCG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PLCG1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLCG1 (see all 1226)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    Selected Novoseek inferred chemical compound relationships for PLCG1 gene (see all 83)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,2-cyclic phosphate 83.4 4 12630878 (1), 2175645 (1), 9003188 (1), 19663462 (1)
    phosphatidylinositol 83.3 242 1814635 (3), 1657936 (3), 1789410 (3), 9136078 (3) (see all 99)
    tyrosine 82 532 9570517 (7), 1533389 (6), 1372020 (6), 11502583 (6) (see all 99)
    inositol 1,4,5 trisphosphate 71.4 45 8327490 (3), 1380035 (1), 8717070 (1), 19179337 (1) (see all 35)
    phosphotyrosine 69.8 22 19955438 (2), 8555205 (1), 10987838 (1), 11208605 (1) (see all 17)
    pp36 68.5 1 7544353 (1)
    phosphoinositide 66.3 23 8653074 (2), 9148771 (2), 17558519 (2), 8641669 (1) (see all 16)
    herbimycin a 66.1 7 11208605 (1), 10100621 (1), 8334306 (1), 7534790 (1) (see all 6)
    u 73122 64.5 5 17962359 (1), 11370672 (1), 14500405 (1), 15182730 (1) (see all 5)
    inositol 64.4 16 16000869 (2), 2173922 (2), 1814635 (1), 8386017 (1) (see all 14)



    Find genes that share compounds with PLCG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PLCG1 gene (2 alternative transcripts): 
    NM_002660.2  NM_182811.1  

    Unigene Cluster for PLCG1:

    Phospholipase C, gamma 1
    Hs.268177  [show with all ESTs]
    Unigene Representative Sequence: AB210028
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000244007(uc010ggf.3 uc002xjo.1 uc010zwe.1) ENST00000373271(uc002xjp.1)
    ENST00000490253 ENST00000483646 ENST00000492148 ENST00000470528 ENST00000473632
    ENST00000465571 ENST00000477870 ENST00000483175 ENST00000599785 ENST00000461641
    ENST00000608689 ENST00000608885 ENST00000609821 ENST00000609257 ENST00000607954
    ENST00000373272
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PLCG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLCG1 (see all 46):
    hsa-miR-429 hsa-miR-4328 hsa-miR-938 hsa-miR-30d hsa-miR-449a hsa-miR-218 hsa-miR-30a hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidPLCG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PLCG1
    Predesigned siRNA for gene silencing in human, mouse, rat PLCG1
    Clone
    Products:
         
    OriGene clones in human, mouse for PLCG1 (see all 13)
    OriGene ORF clones in mouse, rat for PLCG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLCG1 (NM_182811)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCG1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PLCG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCG1
      QuantiTect SYBR Green Assays in human, mouse, rat PLCG1
      QuantiFast Probe-based Assays in human, mouse, rat PLCG1

    Additional mRNA sequence: 

    AB210028.1 AF147391.1 AK098745.1 AK297370.1 AK309606.1 AL110247.1 BC131750.1 BC136466.1 
    BC144136.1 HQ013235.1 M34667.1 

    20 DOTS entries:

    DT.86842930  DT.100646071  DT.102842995  DT.86844955  DT.100657845  DT.91918243  DT.95345097  DT.120819530 
    DT.92010662  DT.92433180  DT.95291216  DT.120819556  DT.92034936  DT.92433177  DT.95353236  DT.95353248 
    DT.97820201  DT.100708296  DT.100893975  DT.95253741 

    Selected AceView cDNA sequences (see all 183):

    BM711309 BQ440546 AA778686 AA902444 BM557119 NM_182811 NM_002660 BM561485 
    BF060861 AA641649 BU164407 BU726000 BQ069687 AA441941 CD672666 BE350139 
    AW851295 BQ900599 AL708196 BQ882869 AL110247 BM450712 BU741495 BP368124 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLCG1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
    SP1:                                      -                 -                             -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:        -                             -                                                                                                                     
    SP5:                                      -                                                                                                                     

    ExUns: 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b
    SP1:  -                             -                             -           -                                                                           
    SP2:                                                              -           -                                                                           
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for PLCG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PLCG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTAAAAA
    PLCG1 Expression
    About this image


    PLCG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Somite (Muscoskeletal System)    fully expand to see all 5 entries
             Sacral Somite Cells Sacral Somite
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Ovary (Reproductive System)
     
     Uterus (Reproductive System)
    PLCG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLCG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268177
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLCG1: 
              Hypertension in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Synaptic Plasticity in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PLCG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCG1
    QuantiTect SYBR Green Assays in human, mouse, rat PLCG1
    QuantiFast Probe-based Assays in human, mouse, rat PLCG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PLCG1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcg11 , 5 phospholipase C, gamma 11, 5 90.36(n)1
    96.94(a)1
      2 (80.97 cM)5
    188031  NM_021280.31  NP_067255.21 
     1607313005 
    chicken
    (Gallus gallus)
    Aves PLCG11 phospholipase C, gamma 1 81.64(n)
    88.69(a)
      419175  XM_004947012.1  XP_004947069.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLCG16
    phospholipase C, gamma 1
    86(a)
    1 ↔ 1
    GL343291.1(861895-948856)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF090112.12   -- 77.79(n)    AF090112.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY163168.12   -- 78.57(n)   373867  AY163168.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sl1 , 3
    1-phosphatidylinositol-4,5-bisphosphate
    phosphodiesterase3
    small wing1
    41(a)3
    52.75(n)1
    44.76(a)1
      326011  NM_057378.21  NP_476726.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T01E8.33
    plc-31
    1-phosphatidylinositol-4,5-bisphosphate
    phosphodiesterase3
    plc-31
    38(a)3
    47(n)1
    39.73(a)1
      II(10222786-10228975)3
    1745861  NM_063804.41  NP_496205.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PLC16
    Phospholipase C, hydrolyzes phosphatidylinositol 4...
    25(a)
    1 → many
    XVI(35236-37845) YPL268W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G559401 AT3G55940 44.98(n)
    36.48(a)
      824760  NM_115452.1  NP_191153.1 


    ENSEMBL Gene Tree for PLCG1 (if available)
    TreeFam Gene Tree for PLCG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PLCG1 gene
    PLCG22  PLCE12  
    3 SIMAP similar genes for PLCG1 using alignment to 5 protein entries:     PLCG1_HUMAN (see all proteins):
    DKFZp434N101    PLCG1 variant protein    PLCG2

    Find genes that share paralogs with PLCG1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PLCG1 (see all 1023)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774197051,2
    C--39764374(+) GTGCCA/TGGCAG 2 -- us2k10--------
    rs1404326291,2
    --39764385(+) CCGACC/TCACTG 2 -- us2k10--------
    rs1893232911,2
    --39764442(+) TCAATA/TTTGGC 2 -- us2k10--------
    rs342556991,2
    C,F--39764595(+) AACTGG/ATGAGA 2 -- us2k15Minor allele frequency- A:0.01NS 190
    rs352873681,2
    C,F,H--39764681(+) TTTAGC/TCTGGA 2 -- us2k19Minor allele frequency- T:0.01EA NS NA 362
    rs354813641,2
    C,F--39764702(+) CATGAT/CTTAAT 2 -- us2k17Minor allele frequency- C:0.07NS WA NA 428
    rs1817478971,2
    --39764725(+) ATTTAA/GAGCAT 2 -- us2k10--------
    rs1867742271,2
    --39764773(+) AAAACC/GAAACA 2 -- us2k10--------
    rs1403814771,2
    C--39764926(+) GCCGCA/G/TTTCTG 2 -- us2k10--------
    rs346216041,2
    C,F--39764972(+) GGGAAG/AGCGAG 2 -- us2k15Minor allele frequency- A:0.01NS 174

    HapMap Linkage Disequilibrium report for PLCG1 (39765600 - 39811629 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PLCG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833983CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLCG1
    DNA2.0 Custom Variant and Variant Library Synthesis for PLCG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 172420    OMIM disorders: --

    1 disease for PLCG1:    
    About MalaCards
    mycobacterium kansasii

    1 disease from the University of Copenhagen DISEASES database for PLCG1:
    Cancer

    Find genes that share disorders with PLCG1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PLCG1 gene (see all 37)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paroxysmal hemoglobinuria nocturnal 50.8 1 2141043 (1)
    tangier disease 31.9 1 9888863 (1)
    leukemia t-cell 22.5 1 18687687 (1)
    pheochromocytoma 20.8 1 19657563 (1)
    astrocytoma 10 2 15317582 (1), 10800962 (1)
    leukemia 6.45 1 9157328 (1)
    tumors 6.18 30 14500405 (4), 7812955 (3), 9136078 (3), 16093435 (2) (see all 18)
    niddm 4.09 3 1639386 (1), 9285775 (1)
    virus infection 3.06 1 7886947 (1)
    alzheimers disease 2.3 1 1628221 (1)

    Genetic Association Database (GAD): PLCG1
    Human Genome Epidemiology (HuGE) Navigator: PLCG1 (12 documents)

    Export disorders for PLCG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PLCG1 gene, integrated from 10 sources (see all 1031):
    (articles sorted by number of sources associating them with PLCG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. (PubMed id 2167438)1, 2, 3 Burgess W.H.... Jaye M. (Mol. Cell. Biol. 1990)
    2. Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. (PubMed id 8657103)1, 2, 9 Law C.L.... Clark E.A. (Mol. Cell. Biol. 1996)
    3. Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration. (PubMed id 17229814)1, 2, 9 Wang Y.... Khurana S. (Am. J. Physiol. 2007)
    4. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. (PubMed id 11259588)1, 2, 9 Baker J.E.... Weiss A. (Mol. Cell. Biol. 2001)
    5. Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. (PubMed id 10488157)1, 2, 9 Lindholm C.K.... Welsh M. (J. Biol. Chem. 1999)
    6. Identification of three polymorphisms in the translated region of PLC-gamma1 and their investigation in lithium responsive bipolar disorder. (PubMed id 11353454)1, 4, 9 Ftouhi-Paquin N....Turecki G. (Am. J. Med. Genet. 2001)
    7. The phospholipase C-gamma1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism. (PubMed id 11409699)1, 4, 9 LA...Steen V.M. (Psychiatr. Genet. 2001)
    8. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5335 HGNC: 9065 AceView: PLCG1 Ensembl:ENSG00000124181 euGenes: HUgn5335
    ECgene: PLCG1 Kegg: 5335 H-InvDB: PLCG1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PLCG1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/plcg1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PLCG1 gene:
    Search GeneIP for patents involving PLCG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PLCG1
     
     EMD Millipore genomic analysis products

      
     Antibodies for PLCG1 (PLC-gamma 1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for PLCG1 (PLC-gamma 1)  
     OriGene Antibodies for PLCG1   OriGene RNAi products in human, mouse, rat for PLCG1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PLCG1  
     OriGene MassSpec something-or-other for PLCG1   OriGene clones in human, mouse for PLCG1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PLCG1   OriGene Purified Protein for PLCG1  
     OriGene ORF clones in mouse, rat for PLCG1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PLCG1   OriGene Custom Protein Services for PLCG1  

     
     
     Block miRNA regulation of human, mouse, rat PLCG1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PLCG1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCG1 Predesigned siRNA for gene silencing in human, mouse, rat PLCG1
     QuantiFast Probe-based Assays in human, mouse, rat PLCG1 QuantiTect SYBR Green Assays in human, mouse, rat PLCG1
     PCR Arrays including human, mouse, rat PLCG1 Search Chromatin IP Primers for PLCG1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCG1  GeneGlobe Interaction Network for PLCG1
     Regulatory tfbs in PLCG1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PLCG1 GenScript cDNA clones with any tag delivered in your preferred vector for PLCG1
     GenScript Custom Assay Services for PLCG1 GenScript Custom overexpressing Cell Line Services for PLCG1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for PLCG1 

     Tocris compounds for PLCG1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PLCG1 antibodies
     PLCG1 proteins
     PLCG1 lysates
     Antibodies for PLCG1
     See all of Abcam's Antibodies, Kits and Proteins for PLCG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PLCG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCG1
     SwitchGear 3'UTR luciferase reporter plasmids for PLCG1
     SwitchGear Promoter luciferase reporter plasmids for PLCG1
     ThermoFisher Antibodies for PLCG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCG1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLCG1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLCG1
     LSBio Antibodies in human, mouse, rat for PLCG1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PLCG1
      Search eBioscience for proteins for PLCG1
      Search eBioscience for elisas for PLCG1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PLCG1 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4