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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLCG1 Gene

protein-coding   GIFtS: 70
GCID: GC20P039765

Phospholipase C, Gamma 1

(Previous names: phospholipase C, gamma 1 (formerly subtype 148))
(Previous symbol: PLC1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase C, Gamma 11 2     1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma 12
PLC11 2 3 5     1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma-12
Phospholipase C, Gamma 1 (Formerly Subtype 148)1 2     NCKAP32
Phosphoinositide Phospholipase C-Gamma-12 3     PLC1482
Phospholipase C-Gamma-12 3     PLCgamma12
Phospholipase C-II2 3     inositoltrisphosphohydrolase2
PLC-1482 3     Monophosphatidylinositol Phosphodiesterase2
PLC-II2 3     Phosphatidylinositol Phospholipase C2
PLC-gamma-12 3     Phosphoinositidase C2
EC 3.1.4.113 8     Phosphoinositide Phospholipase C2
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate2     Phospholipase C-1482
1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-12     Triphosphoinositide Phosphodiesterase2

External Ids:    HGNC: 90651   Entrez Gene: 53352   Ensembl: ENSG000001241817   OMIM: 1724205   UniProtKB: P191743   

Export aliases for PLCG1 gene to outside databases

Previous GC identifers: GC20P039494 GC20P040404 GC20P040451 GC20P039199 GC20P036506


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLCG1 Gene:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from
phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in
the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by
SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi,
where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth
factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PLCG1 Gene: 
PLCG1 (phospholipase C, gamma 1) is a protein-coding gene. Diseases associated with PLCG1 include mycobacterium kansasii, and alexia, and among its related super-pathways are Fc epsilon RI signaling pathway and Development HGF signaling pathway. GO annotations related to this gene include receptor signaling protein activity and calcium ion binding. An important paralog of this gene is PLCG2.

UniProtKB/Swiss-Prot: PLCG1_HUMAN, P19174
Function: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol
1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes
activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB,
FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration

summary for PLCG1 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLCG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLCG1 gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PLCG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLCG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.1   Ensembl cytogenetic band:  20q12   HGNC cytogenetic band: 20q12-q13.1

PLCG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCG1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P039765:  view genomic region     (about GC identifiers)

Start:
39,765,600 bp from pter      End:
39,811,629 bp from pter
Size:
46,030 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLCG1_HUMAN, P19174 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1  
Size: 1290 amino acids; 148532 Da
Cofactor: Calcium
Subunit: Interacts with AGAP2 via its SH3 domain. Interacts (via SH2 domain) with RET. Interacts with FLT1
(tyrosine-phosphorylated) (By similarity). Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4
(phosphorylated). Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the
Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent
fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts
(via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively
regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK (By similarity).
Interacts with AXL, FLT4 and KIT. Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein.
Interacts (via the SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites).
Interacts (via SH2 domain) with PDGFRA and PDGFRB (tyrosine phosphorylated). Interacts with PIP5K1C (By
similarity). Interacts with NTRK1 and NTRK2 (phosphorylated upon ligand-binding). Interacts with SYK; activates
PLCG1. Interacts with GRB2, LAT and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with
TESPA1; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the
LAT signalosome
Subcellular location: Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to
ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment
4 PDB 3D structures from and Proteopedia for PLCG1:
1HSQ (3D)        2HSP (3D)        4EY0 (3D)        4FBN (3D)    
Secondary accessions: B7ZLY7 B9EGH4 E1P5W4 Q2V575
Alternative splicing: 2 isoforms:  P19174-1   P19174-2   (Contains a phosphoserine at position 1222)

Explore the universe of human proteins at neXtProt for PLCG1: NX_P19174

Explore proteomics data for PLCG1 at MOPED 

Post-translational modifications:

  • UniProtKB: Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine
    phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR.
    Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its
    phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune
    system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell
    receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in
    T-cells
  • UniProtKB: Ubiquitinated by CBLB in activated T-cells (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P19174

  • 4/13 DME Specific Peptides for PLCG1 (P19174) (see all 13)
     QLSRIYP  VALNFQT  YHGHTLT  SSHNTYL 

    PLCG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLCG1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002651.2  NP_877963.1  

    ENSEMBL proteins: 
     ENSP00000244007   ENSP00000362368   ENSP00000468958   ENSP00000362369  
    Reactome Protein details: P19174
    Human Recombinant Protein Products for PLCG1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PLCG1
    OriGene Protein Over-expression Lysate for PLCG1
    OriGene MassSpec for PLCG1 
    OriGene Custom Protein Services for PLCG1
    GenScript Custom Purified and Recombinant Proteins Services for PLCG1
    Novus Biologicals PLCG1 Protein
    Novus Biologicals PLCG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA17229814
    GO:0005737cytoplasm IDA15702972
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0008180COP9 signalosome IDA--

    PLCG1 for ontologies           About GeneDecksing



    PLCG1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PLCG1
    R&D Systems Antibodies for PLCG1 (PLC-gamma 1)
    Cell Signaling Technology (CST) Antibodies for PLCG1 
    OriGene Antibodies for PLCG1
    OriGene Custom Antibody Services for PLCG1
    GenScript Custom Superior Antibodies Services for PLCG1
    Novus Biologicals PLCG1 Antibodies
    Abcam antibodies for PLCG1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PLCG1
    LSBio Antibodies in human, mouse, rat for PLCG1 

    Assay Products for PLCG1: 
    EMD Millipore Kits and Assays for the Analysis of PLCG1
    OriGene Custom Assay Services for PLCG1
    R&D Systems Proteome Profiler Antibody Arrays for PLCG1 (PLC-gamma 1)
    GenScript Custom Assay Services for PLCG1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing
    EFHAND: EF-hand domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: PLCγ1 
    Phosphoinositide-specific phospholipase C

    5/16 InterPro protein domains (see all 16):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR001192 Pinositol_PLipase_C
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry P19174

    ProtoNet protein and cluster: P19174

    5 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PLCG1_HUMAN, P19174
    Domain: The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction
    with RALGPS1
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 2 PH domains
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain
    Similarity: Contains 2 SH2 domains
    Similarity: Contains 1 SH3 domain


    PLCG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCG1_HUMAN, P19174
    Function: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol
    1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes
    activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB,
    FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
    + diacylglycerol
    Enzyme regulation: Activated by phosphorylation on tyrosine residues

         Genatlas biochemistry entry for PLCG1:
    phospholipase C,gamma 1 (subtype 148),phosphatidylinositol specific,involved in signal transduction,directly
    interacting with phosphorylated PTK2 to promote adhesion-dependent association of the two molecules and increase
    inositol-phosphate production (mouse fibroblasts)

         Enzyme Number (IUBMB): EC 3.1.4.111 2

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS--
    GO:0004629phospholipase C activity TAS--
    GO:0004871signal transducer activity ----
    GO:0005057receptor signaling protein activity NAS7681365
    GO:0005168neurotrophin TRKA receptor binding IPI15488758
         
    PLCG1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Plcg1):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     hearing/vestibular/ear  hematopoietic system  immune system  integument  mortality/aging 

    PLCG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PLCG1: Plcg1tm1Ine Plcg1tm1Gcrp

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLCG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLCG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLCG1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLCG1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCG1
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCG1 (see all 46):
    hsa-miR-429 hsa-miR-4328 hsa-miR-938 hsa-miR-30d hsa-miR-449a hsa-miR-218 hsa-miR-30a hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidPLCG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLCG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLCG1
    Sirion Biotech Customized adenovirus for overexpression of PLCG1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PLCG1 (see all 11)
    OriGene ORF clones in mouse, rat for PLCG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLCG1 (NM_182811)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCG1
    Sirion Biotech Customized lentivirus for stable overexpression of PLCG1 
                         Customized lentivirus expression plasmids for stable overexpression of PLCG1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLCG1
    Search LifeMap BioReagents cell lines for PLCG1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCG1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLCG1 About   (see all 129)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Fc-epsilon receptor I signaling in mast cells0.33
    Immune response BCR pathway0.45
    Immune response CD16 signaling in NK cells0.32
    Fc epsilon RI signaling pathway0.40
    Immune response Role of DAP12 receptors in NK cells0.32
    VEGF signaling pathway0.39
    Natural killer cell mediated cytotoxicity0.31
    2Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Neurotrophin signaling pathway0.36
    Development PDGF signaling via MAPK cascades0.41
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    Apoptosis and survival NGF signaling pathway0.36
    3ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    4Development EGFR signaling pathway
    Development EGFR signaling pathway0.87
    GDNF-Family Ligands and Receptor Interactions0.41
    Development ERBB-family signaling0.57
    EGF Pathway0.41
    Development GDNF family signaling0.45
    BDNF Pathway0.39
    5Anandamide biosynthesis and metabolism
    D-myo-inositol-5-phosphate metabolism0.50
    Anandamide biosynthesis and metabolism0.34
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.50
    phospholipases0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/31 EMD Millipore Pathways for PLCG1 (see all 31)
        Transcription Transcription factor Tubby signaling pathways
    Development VEGF signaling and activation
    Apoptosis and survival NGF signaling pathway
    Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells

    1 R&D Systems Pathway for PLCG1
        VEGF - VEGF R2 Signaling Pathways

    5/86 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLCG1 (see all 86)
        Fc-GammaR Pathway
    Intracellular Calcium Signaling
    UVA-Induced MAPK Signaling
    PACAP Signaling
    ITK and TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for PLCG1
        Ca, cAMP and Lipid Signaling

    5/32 GeneGo (Thomson Reuters) Pathways for PLCG1 (see all 32)
        Anandamide biosynthesis and metabolism
    Development FGF-family signaling
    Development EGFR signaling pathway
    Immune response CD28 signaling
    Immune response CD16 signaling in NK cells

    5/40 BioSystems Pathways for PLCG1 (see all 40)
        Angiogenesis
    Myometrial Relaxation and Contraction Pathways
    EGFR1 Signaling Pathway
    ErbB signaling pathway
    Signaling Pathways in Glioblastoma

    5/52        Reactome Pathways for PLCG1 (see all 52)
        FCERI mediated MAPK activation
    Signaling by EGFR in Cancer
    Inositol phosphate metabolism
    Downstream signal transduction
    Signal Transduction

    3 PharmGKB Pathways for PLCG1
        EGFR Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/22         Kegg Pathways  (Kegg details for PLCG1) (see all 22):
        Inositol phosphate metabolism
    Metabolic pathways
    ErbB signaling pathway
    Calcium signaling pathway
    NF-kappa B signaling pathway


    PLCG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLCG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/428 Interacting proteins for PLCG1 (P191741, 2, 3 ENSP000002440074) via UniProtKB, MINT, STRING, and/or I2D (see all 428)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INSRP062132, 3, ENSP000003038304MINT-6805867 MINT-6805048 MINT-6805152 MINT-6805846 MINT-6805776 MINT-6805101 MINT-6805266 MINT-6805899 MINT-6805199 I2D: score=2 STRING: ENSP00000303830
    AKT1P317492, 3, ENSP000002702024MINT-7146749 MINT-7146647 MINT-7146716 MINT-7146688 MINT-7146767 MINT-7146702 MINT-7146731 MINT-7146671 MINT-7146657 I2D: score=1 STRING: ENSP00000270202
    LATO435611, 2, 3, ENSP000003541194EBI-79387,EBI-1222766 MINT-8032266 MINT-8033981 MINT-8027843 MINT-8027828 I2D: score=6 STRING: ENSP00000354119
    SOS1Q078891, 2, 3, ENSP000003846754EBI-79387,EBI-297487 MINT-6805677 MINT-8112795 I2D: score=7 STRING: ENSP00000384675
    DUSP15Q9H1R21, 2, 3, ENSP000003416584EBI-79387,EBI-1752795 MINT-8112495 I2D: score=3 STRING: ENSP00000341658
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity TAS--
    GO:0001701in utero embryonic development IEA--
    GO:0006629lipid metabolic process ----
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    PLCG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLCG1 for compounds           About GeneDecksing

    EMD Millipore small molecules for PLCG1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PLCG1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    10/1226 HMDB Compounds for PLCG1 (see all 1226)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    10/83 Novoseek inferred chemical compound relationships for PLCG1 gene (see all 83)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,2-cyclic phosphate 83.4 4 12630878 (1), 2175645 (1), 9003188 (1), 19663462 (1)
    phosphatidylinositol 83.3 242 1814635 (3), 1657936 (3), 1789410 (3), 9136078 (3) (see all 99)
    tyrosine 82 532 9570517 (7), 1533389 (6), 1372020 (6), 11502583 (6) (see all 99)
    inositol 1,4,5 trisphosphate 71.4 45 8327490 (3), 1380035 (1), 8717070 (1), 19179337 (1) (see all 35)
    phosphotyrosine 69.8 22 19955438 (2), 8555205 (1), 10987838 (1), 11208605 (1) (see all 17)
    pp36 68.5 1 7544353 (1)
    phosphoinositide 66.3 23 8653074 (2), 9148771 (2), 17558519 (2), 8641669 (1) (see all 16)
    herbimycin a 66.1 7 11208605 (1), 10100621 (1), 8334306 (1), 7534790 (1) (see all 6)
    u 73122 64.5 5 17962359 (1), 11370672 (1), 14500405 (1), 15182730 (1) (see all 5)
    inositol 64.4 16 16000869 (2), 2173922 (2), 1814635 (1), 8386017 (1) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about PLCG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLCG1 gene (2 alternative transcripts): 
    NM_002660.2  NM_182811.1  

    Unigene Cluster for PLCG1:

    Phospholipase C, gamma 1
    Hs.268177  [show with all ESTs]
    Unigene Representative Sequence: AB210028
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000244007(uc010ggf.3 uc002xjo.1 uc010zwe.1) ENST00000373271(uc002xjp.1)
    ENST00000490253 ENST00000483646 ENST00000492148 ENST00000470528 ENST00000473632
    ENST00000465571 ENST00000477870 ENST00000483175 ENST00000599785 ENST00000461641
    ENST00000373272

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    hsa-miR-429 hsa-miR-4328 hsa-miR-938 hsa-miR-30d hsa-miR-449a hsa-miR-218 hsa-miR-30a hsa-miR-3116
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    Additional mRNA sequence: 

    AB210028.1 AF147391.1 AK098745.1 AK297370.1 AK309606.1 AL110247.1 BC131750.1 BC136466.1 
    BC144136.1 HQ013235.1 M34667.1 

    20 DOTS entries:

    DT.86842930  DT.100646071  DT.102842995  DT.86844955  DT.100657845  DT.91918243  DT.95345097  DT.120819530 
    DT.92010662  DT.92433180  DT.95291216  DT.120819556  DT.92034936  DT.92433177  DT.95353236  DT.95353248 
    DT.97820201  DT.100708296  DT.100893975  DT.95253741 

    24/183 AceView cDNA sequences (see all 183):

    BQ015238 AA641649 BQ440546 BM724867 AI832699 CB215471 AA441941 BU508191 
    AI187110 BU164407 BU194657 AL041726 BX458827 AW851295 BM450712 BX280811 
    BE383104 BQ069687 NM_182811 BU726000 AL708196 BQ946547 BM557119 BU741495 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PLCG1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
    SP1:                                      -                 -                             -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:        -                             -                                                                                                                     
    SP5:                                      -                                                                                                                     

    ExUns: 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b
    SP1:  -                             -                             -           -                                                                           
    SP2:                                                              -           -                                                                           
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for PLCG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLCG1 expression in normal human tissues (normalized intensities)      PLCG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTAAAAA
    PLCG1 Expression
    About this image


    PLCG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Somite (Muscoskeletal System)    fully expand to see all 5 entries
             Thoracic Somite Cells Thoracic Somites
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             brain/midbrain   
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Lung (Respiratory System)

    See PLCG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLCG1

    SOURCE GeneReport for Unigene cluster: Hs.268177
        SABiosciences Expression via Pathway-Focused PCR Arrays including PLCG1: 
              Hypertension in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              VEGF Signaling in human mouse rat
              Synaptic Plasticity in human mouse rat
              Cell Motility in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PLCG1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcg11 , 5 phospholipase C, gamma 11, 5 90.36(n)1
    96.94(a)1
      2 (80.97 cM)5
    188031  NM_021280.31  NP_067255.21 
     1607313005 
    chicken
    (Gallus gallus)
    Aves PLCG11 phospholipase C, gamma 1 81.69(n)
    88.75(a)
      419175  XM_003642501.1  XP_003642549.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLCG16
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    86(a)
    72(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    GL343291.1(861895-948856)
    GL344060.1(29211-78448)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF090112.12   -- 77.79(n)    AF090112.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY163168.12   -- 78.57(n)   373867  AY163168.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sl3
    1-phosphatidylinositol-4,5-bisphosphate
    phosphodiesterase
    41(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea T01E8.33 1-phosphatidylinositol-4,5-bisphosphate
    phosphodiesterase
    38(a)   II(10222786-10228975)   --


    ENSEMBL Gene Tree for PLCG1 (if available)
    TreeFam Gene Tree for PLCG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLCG1 gene
    PLCG22  
    3 SIMAP similar genes for PLCG1 using alignment to 2 protein entries:     PLCG1_HUMAN (see all proteins):
    DKFZp434N101    PLCG1 variant protein    PLCG2

    PLCG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1023 SNPs in PLCG1 are shown (see all 1023)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774197051,2
    C--39764374(+) GTGCCA/TGGCAG 2 -- us2k10--------
    rs1404326291,2
    --39764385(+) CCGACC/TCACTG 2 -- us2k10--------
    rs1893232911,2
    --39764442(+) TCAATA/TTTGGC 2 -- us2k10--------
    rs342556991,2
    C,F--39764595(+) AACTGG/ATGAGA 2 -- us2k15Minor allele frequency- A:0.01NS 190
    rs352873681,2
    C,F,H--39764681(+) TTTAGC/TCTGGA 2 -- us2k19Minor allele frequency- T:0.01EA NS NA 362
    rs354813641,2
    C,F--39764702(+) CATGAT/CTTAAT 2 -- us2k17Minor allele frequency- C:0.07NS WA NA 428
    rs1817478971,2
    --39764725(+) ATTTAA/GAGCAT 2 -- us2k10--------
    rs1867742271,2
    --39764773(+) AAAACC/GAAACA 2 -- us2k10--------
    rs1403814771,2
    C--39764926(+) GCCGCA/G/TTTCTG 2 -- us2k10--------
    rs346216041,2
    C,F--39764972(+) GGGAAG/AGCGAG 2 -- us2k15Minor allele frequency- A:0.01NS 174

    HapMap Linkage Disequilibrium report for PLCG1 (39765600 - 39811629 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PLCG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833983CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 172420    OMIM disorders: --

    20/62 diseases for PLCG1 (see all 62):    About MalaCards
    mycobacterium kansasii    alexia    hemoglobinuria    craniosynostosis, syndromic
    tangier disease    paroxysmal nocturnal hemoglobinuria    hepatitis e    craniosynostosis
    wiskott-aldrich syndrome    phaeochromocytoma    t cell deficiency    dwarfism
    bipolar disorder    pemphigus    neurologic diseases    burkitt's lymphoma
    protein s deficiency    meningioma    pheochromocytoma    gout

    1 disease from the University of Copenhagen DISEASES database for PLCG1:
    Cancer

    PLCG1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/37 Novoseek inferred disease relationships for PLCG1 gene (see all 37)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paroxysmal hemoglobinuria nocturnal 50.8 1 2141043 (1)
    tangier disease 31.9 1 9888863 (1)
    leukemia t-cell 22.5 1 18687687 (1)
    pheochromocytoma 20.8 1 19657563 (1)
    astrocytoma 10 2 15317582 (1), 10800962 (1)
    leukemia 6.45 1 9157328 (1)
    tumors 6.18 30 14500405 (4), 7812955 (3), 9136078 (3), 16093435 (2) (see all 18)
    niddm 4.09 3 1639386 (1), 9285775 (1)
    virus infection 3.06 1 7886947 (1)
    alzheimers disease 2.3 1 1628221 (1)

    Genetic Association Database (GAD): PLCG1
    Human Genome Epidemiology (HuGE) Navigator: PLCG1 (12 documents)

    Export disorders for PLCG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLCG1 gene, integrated from 9 sources (see all 1028):
    (articles sorted by number of sources associating them with PLCG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. (PubMed id 2167438)1, 2, 3 Burgess W.H.... Jaye M. (1990)
    2. Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. (PubMed id 8657103)1, 2, 9 Law C.L....Clark E.A. (1996)
    3. Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration. (PubMed id 17229814)1, 2, 9 Wang Y....Khurana S. (2007)
    4. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. (PubMed id 11259588)1, 2, 9 Baker J.E....Weiss A. (2001)
    5. Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. (PubMed id 10488157)1, 2, 9 Lindholm C.K.... Welsh M. (1999)
    6. Identification of three polymorphisms in the translated region of PLC-gamma1 and their investigation in lithium responsive bipolar disorder. (PubMed id 11353454)1, 4, 9 Ftouhi-Paquin N....Turecki G. (2001)
    7. The phospholipase C-gamma1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism. (PubMed id 11409699)1, 4, 9 Lovlie R....Steen V.M. (2001)
    8. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5335 HGNC: 9065 AceView: PLCG1 Ensembl:ENSG00000124181 euGenes: HUgn5335
    ECgene: PLCG1 Kegg: 5335 H-InvDB: PLCG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLCG1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/plcg1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLCG1 gene:
    Search GeneIP for patents involving PLCG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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