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PLCG1 Gene

protein-coding GIFtS: 71

GC20P039199

phospholipase C, gamma 1
(Previous names: phospholipase C, gamma 1 (formerly subtype 148) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PLC1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate ^²
EC 3.1.4.11 ^³
OTTHUMP00000031787 ^²
OTTHUMP00000178982 ^²
PLC-148 ^³
PLC-II ^¹, ², ³
PLC-gamma-1 ^², ³
PLC1 ^², ³, ⁵
PLC148 ^¹, ²
PLCgamma1 ^¹, ²
inositoltrisphosphohydrolase ^²

Descriptions
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 ^²
Phosphoinositide phospholipase C ^², ³
Phospholipase C-gamma-1 ^³
monophosphatidylinositol phosphodiesterase ^²
phosphatidylinositol phospholipase C ^²
phosphoinositidase C ^²
phospholipase C, gamma 1 ^²
phospholipase C, gamma 1 (formerly subtype 148) ^¹, ²
phospholipase C-148 ^²
triphosphoinositide phosphodiesterase ^²

External Ids
HGNC: 9065¹
Entrez Gene: 5335²
UniProtKB: P19174³
Ensembl: ENSG00000124181⁷

Search outside databases for aliases for PLCG1 gene

Previous GC identifers: GC20P039494 GC20P040404 GC20P040451

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PLCG1:

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and

diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a

cofactor and plays an important role in the intracellular transduction of receptor-mediated

tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras

guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras.

Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1

(acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding

different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: PLCG1_HUMAN, P19174

Function: PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast

growth factor)-activated tyrosine kinase

Gene Wiki entry for PLCG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PLCG1 gene

Entrez Gene cytogenetic band: 20q12-q13.1 Ensembl cytogenetic band: 20q12 HGNC cytogenetic band: 20q12-q13.1

PLCG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P039199: (about GC identifiers)

Start:	39,199,014 bp from pter
End:	39,237,775 bp from pter
Size:	38,762 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PLCG1_HUMAN, P19174 (See protein sequence)

Recommended Name: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Size: 1290 amino acids; 148532 Da

Cofactor: Calcium

Subunit: Interacts with AGAP2 via its SH3 domain (By similarity). Interacts with phosphorylated LAT

upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates

with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB

in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3

domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is

selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 and

CLNK (By similarity). Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein

PDB structure from and Proteopedia :

1HSQ (3D)

2HSP (3D)

Secondary accessions: Q2V575

Post-translational modifications:

The receptor-mediated activation of PLC-gamma-1 and PLC-gamma-2 involves their phosphorylation by

tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system

receptors¹

Ubiquitinated by CBLB in activated T-cells (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002651.2 NP_877963.1

ENSEMBL proteins:

ENSP00000362368 ENSP00000244007 ENSP00000362369

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PLCG1
	Recombinant Proteins from Abcam (Phospholipase C gamma 1)
	Human Recombinant Proteins from Abnova (PLCG1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005737	cytoplasm	IDA	15702972
GO:0005829	cytosol	EXP	10350061 11048639
GO:0005886	plasma membrane	EXP	11048639

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Antibodies for PLCG1:

	Invitrogen Antibodies for PLCG1
	Millipore Mono- and Polyclonal Antibodies for the study of PLCG1
	Sigma-Aldrich Antibody Arrays and Antibodies for PLCG1
	R&D Systems Antibodies for PLCG1 (PLC-gamma 1)
	Cell Signaling Technology (CST) Antibodies for PLCG1
	Antibodies from Abcam (Phospholipase C gamma 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PLCG1)
	Novus Biologicals Antibodies for PLCG1

Assays for PLCG1:

	Invitrogen Assays for PLCG1
	Millipore Kits and Assays for the Analysis of PLCG1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P19174

ProtoNet protein and cluster: P19174

5 Blocks protein families:

IPB000008 C2 domain

IPB000909 Phosphatidylinositol-specific phospholipase C

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: PLCG1_HUMAN, P19174

Domain: The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates

interaction with RALGPS1

Similarity: Contains 1 C2 domain

Similarity: Contains 1 EF-hand domain

Similarity: Contains 2 PH domains

Similarity: Contains 1 PI-PLC X-box domain

Similarity: Contains 1 PI-PLC Y-box domain

Similarity: Contains 2 SH2 domains

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PLCG1)
		Millipore RNAi Products for the Analysis of PLCG1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PLCG1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_182811

Applied Biosystems Silencer® siRNAs for PLCG1

Sigma-Aldrich siRNA and siRNA Panels for PLCG1

Sigma-Aldrich shRNA for PLCG1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002660
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002660
untagged cDNA clones in CMV expression vector (see all 2): NM_002660

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002660

UniProtKB/Swiss-Prot: PLCG1_HUMAN, P19174

Function: PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast

growth factor)-activated tyrosine kinase

Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol

1,4,5-trisphosphate + diacylglycerol

Enzyme Number (IUBMB): EC 3.1.4.11

Genatlas biochemistry entry for PLCG1:

phospholipase C,gamma 1 (subtype 148),phosphatidylinositol specific,involved in signal

transduction,directly interacting with phosphorylated PTK2 to promote adhesion-dependent

association of the two molecules and increase inositol-phosphate production (mouse fibroblasts)

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Plcg1):

embryogenesis

growth/size

hematopoietic system

lethality-prenatal/perinatal

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphoinositide phospholipase C activity	NAS	--
GO:0005057	receptor signaling protein activity	NAS	7681365
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	10873601
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/50 Sigma-Aldrich "Your Favorite Gene" Pathways for PLCG1 (Your Favorite Gene powered by Ingenuity) (see all 50 )

Chemokine Signaling
Virus Entry via Endocytic Pathways
ERK/MAPK Signaling
Erythropoietin Signaling
CD28 Signaling in T Helper Cells

GeneDecks PLCG1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for PLCG1

5/347 Interacting proteins for PLCG1 (ENSP00000362369³ P19174^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 347 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹	STRING (score=.991) EBI-79387, EBI-375543
CD22	P20273¹	STRING (score=.786) EBI-79387, EBI-78277
GHR	P10912¹	STRING (score=.808) EBI-79387, EBI-286316
JAK2	O60674¹	STRING (score=.948) EBI-79387, EBI-518647
SOS1	Q07889¹	STRING (score=.98) EBI-79387, EBI-297487

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007242	intracellular signaling cascade	IEA	--
GO:0009395	phospholipid catabolic process	IEA	--
GO:0016042	lipid catabolic process	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for PLCG1 available from Tocris Bioscience

Compound	Action	CAS number
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
U 73122	Phospholipase C inhibitor	[112648-68-7]
D609	Selective PC-PLC inhibitor	[83373-60-8]

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10/29 Novoseek chemical compound relationships for PLCG1 gene (see all 29 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	83.85	242	1814635 (3), 1657936 (3), 1789410 (3), 9136078 (3) (see all 99)
inositol 1,2-cyclic phosphate	82.43	3	12630878 (1), 2175645 (1), 9003188 (1)
tyrosine	82.33	526	9570517 (7), 1533389 (6), 1372020 (6), 11502583 (6) (see all 99)
inositol 1,4,5 trisphosphate	70.74	45	8327490 (3), 1380035 (1), 8717070 (1), 19179337 (1) (see all 35)
phosphotyrosine	69.89	18	8555205 (1), 10987838 (1), 11208605 (1), 8943348 (1) (see all 16)
pp36	69.25	1	7544353 (1)
phosphoinositide	65.61	22	8653074 (2), 9148771 (2), 17558519 (2), 8641669 (1) (see all 15)
pip2	64.15	19	7673143 (3), 7487955 (2), 10085141 (2), 8641669 (1) (see all 11)
lysosulfatide	61.16	1	14511654 (1)
calcium	60.14	155	15872086 (4), 8940074 (4), 16973916 (4), 12632103 (4) (see all 90)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PLCG1)
		Millipore RNAi Products for the Analysis of PLCG1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PLCG1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_182811

Sigma-Aldrich siRNA and siRNA Panels for PLCG1

Sigma-Aldrich shRNA for PLCG1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002660 NM_182811

REFSEQ mRNAs for PLCG1 gene (2 alternative transcripts):

NM_002660.2 NM_182811.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002660 NM_182811

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002660
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002660
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002660

Additional cDNA sequence:

AB210028.1 AF147391.1 AK098745.1 AK297370.1 AK309606.1 AL110247.1 BC131750.1 BC136466.1

BC144136.1 M34667.1

21 DOTS entries:

DT.86842930 DT.100646071 DT.102842995 DT.86844955 DT.100657845 DT.91918243 DT.95345097 DT.120819530

DT.92010662 DT.95291216 DT.92433180 DT.97820201 DT.100649850 DT.120819556 DT.92034936 DT.92433177

DT.95253741 DT.95353236 DT.95353248 DT.100708296 DT.120819573

24/183 AceView cDNA sequences (see all 183 ):

AI832699 BU741495 BU164407 AA778686 AA441941 BM557119 BX458827 BQ882869

BE350139 AL110247 CD672666 BM450712 BM711309 AW851295 AA902444 BQ069687

AA641649 BM561485 NM_182811 AL708196 BQ440546 AI187110 BX280811 BF060861

highest scoring ESTs for PLCG1:

M34667 AA331680 AA385590 AA441941 AA442054 AA476669 AA641649 AA778686 AA852993 AA902444

Unigene Cluster for PLCG1:

Phospholipase C, gamma 1

Hs.268177 [show with all ESTs]

Unigene Representative Sequence: AB210028

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PLCG1 (see all 12 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	^	17	^	18a	·
SP1:													-						-										-
SP2:
SP3:
SP4:			-										-
SP5:													-

ExUns:	18b	^	19	^	20	^	21a	·	21b	^	22a	·	22b	^	23	^	24	^	25a	·	25b	^	26a	·	26b	^	27	^	28a	·	28b	·	28c	^	29	^	30	^	31	^	32	^	33a	·	33b	^	34a	·	34b
SP1:	-										-										-				-
SP2:																					-				-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PLCG1

3 Ensembl transcripts including schematic representations:

ENST00000373271 ENST00000244007 ENST00000373272

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PLCG1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PLCG1

¹ / ² / ³

6 probe-sets matching PLCG1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1082_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.86	M34667	1.00	1.00	1.00	1
34351_at²^{, 3}	U95-A	1	0.31	1.00	0.38	1.14	AL022394	0.20	1.00	0.72	1
216551_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL110247	0.80	1.00	0.91	1
202789_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AL022394	0.20	1.00	0.72	1
216551_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202789_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks PLCG1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCTTAAAAA

SOURCE GeneReport for Unigene cluster: Hs.268177
Expression variation in blood from EXPOLDB for PLCG1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PLCG1 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PLCG1¹	--	phospholipase C, gamma 1	91.48(n) 97.78(a)	485874 XM_542998.2 XP_542998.2
chimpanzee (Pan troglodytes)	PLCG1¹	--	phospholipase C, gamma 1	99.69(n) 99.84(a)	458253 XM_514650.2 XP_514650.2
cow (Bos taurus)	PLCG1¹	--	phospholipase C, gamma 1	90.73(n) 97.06(a)	281987 NM_174425.2 NP_776850.1
rat (Rattus norvegicus)	Plcg1¹	--	phospholipase C, gamma 1	90.13(n) 96.9(a)	25738 NM_013187.1 NP_037319.1
mouse (Mus musculus)	Plcg1^{1, 5}	2 (92.00 cM)⁵	phospholipase C, gamma 1^{1, 5}	90.36(n)¹ 96.94(a)¹	18803¹ NM_021280.3¹ NP_067255.2¹ AF027185⁵ AF027186⁵ (see all 20)

About this table Species with no ortholog for PLCG1

ENSEMBL Gene Tree for PLCG1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PLCG1 gene

PLCG2² PLCL2² PLCL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/343 NCBI SNPs in PLCG1 are shown (see all 343 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 205)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs753381^1,2	A,C,F,H	39230879(-)	`TCTTGA/GTGAAG`	2	I/T	mis¹ ese³		33		NA EA MN EU WA NS	3896
	rs2228246^1,2	C,F,H	39225477(+)	`TGCTCA/GGCTTC`	2	S/G	mis¹		19		MN EU NA EA WA NS	2189
	rs35481364^1,2	C,F	39198116(+)	`CATGAT/CTTAAT`	2	--	ng5¹		5		NS	190
	rs2229348^1,2	C,F	39224724(+)	`CATCAA/CCTACG`	2	T/N	mis¹		7		MN NA NS	300
	rs28362587^1,2	C,F	39199214(+)	`CGGCCG/TCCCGT`	2	--	ng5¹		5		NS	190
	rs34842000^1,2	F	39199197(+)	`GCGGGA/GCCGCG`	2	--	ng5¹		5		NS	190
--	rs35806184^1,2	F	39236638(+)	`GGAAG-/AGCAGCC`	2	--	ut3¹		5		NS	188
	rs35202283^1,2	F	39199161(+)	`CATGGG/TCGGTG`	2	--	ng5¹		5		NS	190
--	rs6029559^1,2	A	39238204(+)	`TCTTCC/TTGAAG`	2	--	ng3¹		0	--	--	--	--
--	rs35498383^1,2	F	39198428(+)	`TGGGA-/ATGCTG`	2	--	ng5¹		5		NS	190

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HapMap Linkage Disequilibrium images for PLCG1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 172420

10/35 Novoseek disease relationships for PLCG1 gene (see all 35 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
paroxysmal hemoglobinuria nocturnal	51.66	1	2141043 (1)
tangier disease	32.84	1	9888863 (1)
leukemia t-cell	23.39	1	18687687 (1)
astrocytoma	11.16	2	15317582 (1), 10800962 (1)
leukemia	7.67	1	9157328 (1)
tumors	5.62	30	14500405 (4), 7812955 (3), 9136078 (3), 16093435 (2) (see all 18)
niddm	4.19	3	1639386 (1), 9285775 (1)
virus infection	3.08	1	7886947 (1)
promyelocytic leukemia	3.01	1	2166587 (1)
alzheimers disease	2.41	1	1628221 (1)

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Genetic Association Database: PLCG1
Human Genome Epidemiology Navigator: PLCG1 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/869 PubMed articles for PLCG1 gene (see all 869 ):

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. (PubMed id 2167438)^{2, 3, 4} Burgess W.H.... Jaye M. (1990)
Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. (PubMed id 10488157)^{1, 3, 4} Lindholm C.K.... Welsh M. (1999)
Identification of three polymorphisms in the translated region of PLC-gamma1 and their investigation in lithium responsive bipolar disorder. (PubMed id 11353454)^{1, 3, 6} Ftouhi-Paquin N....Turecki G. (2001)
The phospholipase C-gamma1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism. (PubMed id 11409699)^{1, 3, 6} Lovlie R....Steen V.M. (2001)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)
Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells. (PubMed id 15270728)^{3, 4} Taguchi T.... Fujimoto J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. (PubMed id 10873601)^{3, 4} Felschow D.M.... Hoehn G.T. (2000)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5335	HGNC: 9065	AceView: PLCG1	Ensembl:ENSG00000124181	euGenes: HUgn5335
ECgene: PLCG1	H-InvDB: PLCG1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/plcg1/

Licensable Technologies for PLCG1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PLCG1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

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Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PLCG1-related products

	Millipore Custom Antibody & Bulk Services
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Antibodies & Assays for PLCG1

	Recombinant Proteins (Phospholipase C gamma 1)
	Antibodies (Phospholipase C gamma 1)

Search OriGene for PLCG1

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	Proteins for PLCG1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PLCG1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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PLCG1 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for PLCG1

Summaries
for PLCG1

Genomic Location
for PLCG1

Proteins
for PLCG1

Protein Domains/
Families
for PLCG1

Gene Function
for PLCG1

Pathways & Interactions
for PLCG1

Drugs & Compounds
for PLCG1

Transcripts
for PLCG1

Expression
for PLCG1

Orthologs
for PLCG1

Paralogs
for PLCG1

SNPs/Variants
for PLCG1

Disorders & Mutations
for PLCG1

Medical News
for PLCG1

Publications
for PLCG1

Search for PLCG1

Genome Databases showing PLCG1

Other Databases showing PLCG1

Specialized Databases showing PLCG1

Licensable Technologies
for PLCG1

Services
for PLCG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PLCG1 (Gene Symbol)
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
EC 3.1.4.11
OTTHUMP00000031787
OTTHUMP00000178982
PLC-148
PLC-II
PLC-gamma-1
PLC1
PLC148
PLCgamma1
inositoltrisphosphohydrolase
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
Phosphoinositide phospholipase C
Phospholipase C-gamma-1
monophosphatidylinositol phosphodiesterase
phosphatidylinositol phospholipase C
phosphoinositidase C
phospholipase C, gamma 1
phospholipase C, gamma 1 (formerly subtype 148)
phospholipase C-148
triphosphoinositide phosphodiesterase

PLCG1 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor PLCG1

Summariesfor PLCG1

Genomic Locationfor PLCG1

Proteinsfor PLCG1

Protein Domains/Familiesfor PLCG1

Gene Functionfor PLCG1

Pathways & Interactionsfor PLCG1

Drugs & Compoundsfor PLCG1

Transcriptsfor PLCG1

Expression for PLCG1

Orthologsfor PLCG1

Paralogsfor PLCG1

SNPs/Variantsfor PLCG1

Disorders & Mutationsfor PLCG1

Medical Newsfor PLCG1

Publicationsfor PLCG1

Search for PLCG1

Genome Databases showing PLCG1

Other Databases showing PLCG1

Specialized Databases showing PLCG1

Licensable Technologiesfor PLCG1

Servicesfor PLCG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PLCG1

Summaries
for PLCG1

Genomic Location
for PLCG1

Proteins
for PLCG1

Protein Domains/
Families
for PLCG1

Gene Function
for PLCG1

Pathways & Interactions
for PLCG1

Drugs & Compounds
for PLCG1

Transcripts
for PLCG1

Expression
for PLCG1

Orthologs
for PLCG1

Paralogs
for PLCG1

SNPs/Variants
for PLCG1

Disorders & Mutations
for PLCG1

Medical News
for PLCG1

Publications
for PLCG1

Licensable Technologies
for PLCG1

Services
for PLCG1