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Aliases for PLCG1 Gene

Aliases for PLCG1 Gene

  • Phospholipase C, Gamma 1 2 3
  • PLC1 3 4 6
  • Phospholipase C, Gamma 1 (Formerly Subtype 148) 2 3
  • Phosphoinositide Phospholipase C-Gamma-1 3 4
  • Phospholipase C-Gamma-1 3 4
  • Phospholipase C-II 3 4
  • PLC-Gamma-1 3 4
  • EC 3.1.4.11 4 63
  • PLC-148 3 4
  • PLC-II 3 4
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 3
  • 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma 1 3
  • 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma-1 3
  • 1-Phosphatidyl-D-Myo-Inositol-4,5-Bisphosphate 3
  • Monophosphatidylinositol Phosphodiesterase 3
  • Triphosphoinositide Phosphodiesterase 3
  • Phosphatidylinositol Phospholipase C 3
  • Phosphoinositide Phospholipase C 3
  • Inositoltrisphosphohydrolase 3
  • Phosphoinositidase C 3
  • Phospholipase C-148 3
  • PLCgamma1 3
  • NCKAP3 3
  • PLC148 3

External Ids for PLCG1 Gene

Previous HGNC Symbols for PLCG1 Gene

  • PLC1

Previous GeneCards Identifiers for PLCG1 Gene

  • GC20P039494
  • GC20P040404
  • GC20P040451
  • GC20P039199
  • GC20P039765
  • GC20P036506

Summaries for PLCG1 Gene

Entrez Gene Summary for PLCG1 Gene

  • The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLCG1 Gene

PLCG1 (Phospholipase C, Gamma 1) is a Protein Coding gene. Diseases associated with PLCG1 include mycobacterium kansasii. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include calcium ion binding and receptor signaling protein activity. An important paralog of this gene is PLCE1.

UniProtKB/Swiss-Prot for PLCG1 Gene

  • Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.

Tocris Summary for PLCG1 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLCG1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCG1 Gene

Genomics for PLCG1 Gene

Regulatory Elements for PLCG1 Gene

Genomic Location for PLCG1 Gene

Start:
41,136,960 bp from pter
End:
41,196,787 bp from pter
Size:
59,828 bases
Orientation:
Plus strand

Genomic View for PLCG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLCG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCG1 Gene

Proteins for PLCG1 Gene

  • Protein details for PLCG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19174-PLCG1_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
    Protein Accession:
    P19174
    Secondary Accessions:
    • B7ZLY7
    • B9EGH4
    • E1P5W4
    • Q2V575

    Protein attributes for PLCG1 Gene

    Size:
    1290 amino acids
    Molecular mass:
    148532 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with AGAP2 via its SH3 domain. Interacts (via SH2 domain) with RET. Interacts with FLT1 (tyrosine-phosphorylated) (By similarity). Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK (By similarity). Interacts with AXL, FLT4 and KIT. Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein. Interacts (via the SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites). Interacts (via SH2 domain) with PDGFRA and PDGFRB (tyrosine phosphorylated). Interacts with PIP5K1C (By similarity). Interacts with NTRK1 and NTRK2 (phosphorylated upon ligand-binding). Interacts with SYK; activates PLCG1. Interacts with GRB2, LAT and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with TESPA1; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the LAT signalosome.

    Three dimensional structures from OCA and Proteopedia for PLCG1 Gene

    Alternative splice isoforms for PLCG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCG1 Gene

Proteomics data for PLCG1 Gene at MOPED

Post-translational modifications for PLCG1 Gene

  • Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells.
  • Ubiquitinated by CBLB in activated T-cells.
  • Ubiquitination at Lys178, Lys226, Lys431, Lys440, and Lys941
  • Modification sites at PhosphoSitePlus

Other Protein References for PLCG1 Gene

Domains for PLCG1 Gene

Gene Families for PLCG1 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SH2D :SH2 domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for PLCG1 Gene

Graphical View of Domain Structure for InterPro Entry

P19174

UniProtKB/Swiss-Prot:

PLCG1_HUMAN :
  • P19174
Domain:
  • The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1.
  • Contains 1 C2 domain.
  • Contains 1 EF-hand domain.
  • Contains 2 PH domains.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
  • Contains 2 SH2 domains.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with PLCG1: view

Function for PLCG1 Gene

Molecular function for PLCG1 Gene

GENATLAS Biochemistry: phospholipase C,gamma 1 (subtype 148),phosphatidylinositol specific,involved in signal transduction,directly interacting with phosphorylated PTK2 to promote adhesion-dependent association of the two molecules and increase inositol-phosphate production (mouse fibroblasts)
UniProtKB/Swiss-Prot CatalyticActivity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on tyrosine residues
UniProtKB/Swiss-Prot Function: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.

Enzyme Numbers (IUBMB) for PLCG1 Gene

Gene Ontology (GO) - Molecular Function for PLCG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS --
GO:0004629 phospholipase C activity TAS --
GO:0004871 signal transducer activity --
GO:0005057 receptor signaling protein activity NAS 7681365
GO:0005168 neurotrophin TRKA receptor binding IPI 15488758
genes like me logo Genes that share ontologies with PLCG1: view
genes like me logo Genes that share phenotypes with PLCG1: view

Animal Models for PLCG1 Gene

MGI Knock Outs for PLCG1:

miRNA for PLCG1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for PLCG1 Gene

Localization for PLCG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCG1 Gene

Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCG1 Gene COMPARTMENTS Subcellular localization image for PLCG1 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PLCG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 17229814
GO:0005737 cytoplasm IDA 15702972
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with PLCG1: view

Pathways for PLCG1 Gene

genes like me logo Genes that share pathways with PLCG1: view

Gene Ontology (GO) - Biological Process for PLCG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0001701 in utero embryonic development IEA --
GO:0006629 lipid metabolic process --
GO:0007165 signal transduction TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with PLCG1: view

Compounds for PLCG1 Gene

(5) Tocris Compounds for PLCG1 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]
VU 0155069 Potent and selective PLD1 inhibitor [1130067-06-9]
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor [1244640-48-9]

(1226) HMDB Compounds for PLCG1 Gene

Compound Synonyms Cas Number PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available

(83) Novoseek inferred chemical compound relationships for PLCG1 Gene

Compound -log(P) Hits PubMed IDs
inositol 1,2-cyclic phosphate 83.4 4
phosphatidylinositol 83.3 137
tyrosine 82 228
inositol 1,4,5 trisphosphate 71.4 37
phosphotyrosine 69.8 18
genes like me logo Genes that share compounds with PLCG1: view

Transcripts for PLCG1 Gene

Unigene Clusters for PLCG1 Gene

Phospholipase C, gamma 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCG1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
SP1: - - -
SP2:
SP3:
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for PLCG1 Gene

GeneLoc Exon Structure for
PLCG1
ECgene alternative splicing isoforms for
PLCG1

Expression for PLCG1 Gene

mRNA expression in normal human tissues for PLCG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLCG1 Gene

SOURCE GeneReport for Unigene cluster for PLCG1 Gene Hs.268177

genes like me logo Genes that share expressions with PLCG1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLCG1 Gene

Orthologs for PLCG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCG1 35
  • 99.69 (n)
  • 99.85 (a)
PLCG1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLCG1 35
  • 90.73 (n)
  • 97.06 (a)
PLCG1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCG1 35
  • 91.56 (n)
  • 97.79 (a)
PLCG1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcg1 35
  • 90.36 (n)
  • 96.94 (a)
Plcg1 16
Plcg1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLCG1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLCG1 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcg1 35
  • 90.13 (n)
  • 96.9 (a)
chicken
(Gallus gallus)
Aves PLCG1 35
  • 81.64 (n)
  • 88.69 (a)
PLCG1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCG1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13513 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
plcg1 35
  • 73.21 (n)
  • 77.22 (a)
plcg1 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011152 35
  • 56.08 (n)
  • 49.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta sl 35
  • 52.75 (n)
  • 44.76 (a)
sl 36
  • 42 (a)
OneToMany
sl 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea plc-3 35
  • 47 (n)
  • 39.73 (a)
plc-3 36
  • 32 (a)
OneToMany
T01E8.3 37
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLC1 36
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G55940 35
  • 44.98 (n)
  • 36.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for PLCG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCG1 Gene

ENSEMBL:
Gene Tree for PLCG1 (if available)
TreeFam:
Gene Tree for PLCG1 (if available)

Paralogs for PLCG1 Gene

Paralogs for PLCG1 Gene

Selected SIMAP similar genes for PLCG1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PLCG1: view

Variants for PLCG1 Gene

Sequence variations from dbSNP and Humsavar for PLCG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs760762 -- 41,147,406(+) TACAC(A/C/T)GGAAG intron-variant
rs760763 -- 41,164,548(+) TCCCT(A/G)TGTCC intron-variant
rs760764 -- 41,171,166(+) CACCC(A/G)CAAGC intron-variant
rs926345 -- 41,143,307(+) TGGGA(C/T)GTGGC intron-variant
rs2072880 -- 41,170,433(+) CAGAC(A/T)CATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCG1 Gene

Variant ID Type Subtype PubMed ID
nsv833983 CNV Loss 17160897

Relevant External Links for PLCG1 Gene

HapMap Linkage Disequilibrium report
PLCG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCG1 Gene

Disorders for PLCG1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PLCG1 Gene including...

Search for PLCG1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PLCG1 Gene

(37) Novoseek inferred disease relationships for PLCG1 Gene

Disease -log(P) Hits PubMed IDs
paroxysmal hemoglobinuria nocturnal 50.8 1
tangier disease 31.9 1
leukemia t-cell 22.5 1
pheochromocytoma 20.8 1
astrocytoma 10 2

Relevant External Links for PLCG1

Genetic Association Database (GAD)
PLCG1
Human Genome Epidemiology (HuGE) Navigator
PLCG1
genes like me logo Genes that share disorders with PLCG1: view

No data available for UniProtKB/Swiss-Prot for PLCG1 Gene

Publications for PLCG1 Gene

  1. Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. (PMID: 8657103) Law C.L. … Clark E.A. (Mol. Cell. Biol. 1996) 3 4 23
  2. Identification of three polymorphisms in the translated region of PLC-gamma1 and their investigation in lithium responsive bipolar disorder. (PMID: 11353454) Ftouhi-Paquin N. … Turecki G. (Am. J. Med. Genet. 2001) 3 23 48
  3. The phospholipase C-gamma1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism. (PMID: 11409699) LA … Steen V.M. (Psychiatr. Genet. 2001) 3 23 48
  4. Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration. (PMID: 17229814) Wang Y. … Khurana S. (Am. J. Physiol. 2007) 3 4 23
  5. Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. (PMID: 2167438) Burgess W.H. … Jaye M. (Mol. Cell. Biol. 1990) 2 3 4

Products for PLCG1 Gene

Sources for PLCG1 Gene

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