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Aliases for PLCE1 Gene

Aliases for PLCE1 Gene

  • Phospholipase C Epsilon 1 2 3 5
  • Phosphoinositide Phospholipase C-Epsilon-1 3 4
  • Pancreas-Enriched Phospholipase C 3 4
  • Phosphoinositide Phospholipase C 2 3
  • Phospholipase C-Epsilon-1 3 4
  • PLC-Epsilon-1 3 4
  • EC 3.1.4.11 4 61
  • PLCE 3 4
  • PPLC 3 4
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Epsilon-1 3
  • Phosphoinositide-Specific Phospholipase C Epsilon-1 3
  • Phospholipase C, Epsilon 1 2
  • Nephrosis Type 3 2
  • KIAA1516 4
  • NPHS3 3

External Ids for PLCE1 Gene

Previous GeneCards Identifiers for PLCE1 Gene

  • GC10P094683
  • GC10P095024
  • GC10P095921
  • GC10P095455
  • GC10P095743
  • GC10P089380
  • GC10P095753

Summaries for PLCE1 Gene

Entrez Gene Summary for PLCE1 Gene

  • This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

GeneCards Summary for PLCE1 Gene

PLCE1 (Phospholipase C Epsilon 1) is a Protein Coding gene. Diseases associated with PLCE1 include Nephrotic Syndrome, Type 3 and Sporadic Idiopathic Steroid-Resistant Nephrotic Syndrome With Diffuse Mesangial Sclerosis. Among its related pathways are NFAT and Cardiac Hypertrophy and CREB Pathway. GO annotations related to this gene include calcium ion binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLCG1.

UniProtKB/Swiss-Prot for PLCE1 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.

Tocris Summary for PLCE1 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCE1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCE1 Gene

Genomics for PLCE1 Gene

Regulatory Elements for PLCE1 Gene

Enhancers for PLCE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PLCE1 on UCSC Golden Path with GeneCards custom track

Promoters for PLCE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PLCE1 Gene

Chromosome:
10
Start:
93,993,989 bp from pter
End:
94,332,823 bp from pter
Size:
338,835 bases
Orientation:
Plus strand

Genomic View for PLCE1 Gene

Genes around PLCE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCE1 Gene

Proteins for PLCE1 Gene

  • Protein details for PLCE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P212-PLCE1_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
    Protein Accession:
    Q9P212
    Secondary Accessions:
    • A6NGW0
    • A6NLA1
    • A7MBN7
    • A8K1D7
    • B9EIJ6
    • Q1X6H8
    • Q5VWL4
    • Q5VWL5
    • Q9H9X8
    • Q9HBX6
    • Q9HC53
    • Q9UHV3

    Protein attributes for PLCE1 Gene

    Size:
    2302 amino acids
    Molecular mass:
    258715 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with RHOA (By similarity). Interacts with IQGAP1, HRAS, RAP1A, RAP2A, RAP2B and RRAS.
    SequenceCaution:
    • Sequence=AAF22005.1; Type=Frameshift; Positions=1131; Evidence={ECO:0000305}; Sequence=AAG17145.2; Type=Frameshift; Positions=2296; Evidence={ECO:0000305}; Sequence=BAA96040.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14090.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70739.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73288.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73757.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16674.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLCE1 Gene

    Alternative splice isoforms for PLCE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCE1 Gene

Selected DME Specific Peptides for PLCE1 Gene

Post-translational modifications for PLCE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCE1 Gene

Domains & Families for PLCE1 Gene

Suggested Antigen Peptide Sequences for PLCE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P212

UniProtKB/Swiss-Prot:

PLCE1_HUMAN :
  • The Ras-associating domain 1 is degenerated and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane.
Domain:
  • The Ras-associating domain 1 is degenerated and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane.
  • The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway.
  • Contains 1 C2 domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
  • Contains 2 Ras-associating domains.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with PLCE1: view

Function for PLCE1 Gene

Molecular function for PLCE1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by the heterotrimeric G-protein subunits GNA12, GNA13 and GNB1-GNG2. Activated by HRAS, RAP1A, RHOA, RHOB, RHOC, RRAS and RRAS2. Activated by the G(s)-coupled GPCRs ADRB2, PTGER1 and CHRM3 through cyclic-AMP formation and RAP2B activation. Inhibited by G(i)-coupled GPCRs.
UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.
UniProtKB/Swiss-Prot Induction:
Overexpressed during heart failure.

Enzyme Numbers (IUBMB) for PLCE1 Gene

Gene Ontology (GO) - Molecular Function for PLCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS --
GO:0004629 phospholipase C activity IDA 11022047
GO:0005057 receptor signaling protein activity TAS 11022048
GO:0005085 guanyl-nucleotide exchange factor activity TAS 11022047
GO:0005515 protein binding IPI 11022048
genes like me logo Genes that share ontologies with PLCE1: view
genes like me logo Genes that share phenotypes with PLCE1: view

Human Phenotype Ontology for PLCE1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLCE1 Gene

MGI Knock Outs for PLCE1:

Animal Model Products

CRISPR Products

miRNA for PLCE1 Gene

miRTarBase miRNAs that target PLCE1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PLCE1 Gene

Localization for PLCE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCE1 Gene

Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCE1 Gene COMPARTMENTS Subcellular localization image for PLCE1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
plasma membrane 5
nucleus 3
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 11022048
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PLCE1: view

Pathways & Interactions for PLCE1 Gene

genes like me logo Genes that share pathways with PLCE1: view

Interacting Proteins for PLCE1 Gene

SIGNOR curated interactions for PLCE1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PLCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 11022047
GO:0001558 regulation of cell growth TAS 11022047
GO:0006644 phospholipid metabolic process IC 11022048
GO:0006651 diacylglycerol biosynthetic process TAS 11022047
GO:0006940 regulation of smooth muscle contraction TAS 11022047
genes like me logo Genes that share ontologies with PLCE1: view

Drugs & Compounds for PLCE1 Gene

(3) Drugs for PLCE1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Guanosine triphosphate Experimental Pharma 0
calcium Nutra 0

(386) Additional Compounds for PLCE1 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
Inositol 1,4,5-trisphosphate
  • 1D-Myo-Inositol 1,4,5-trisphosphate
  • D-Myo-Inositol 1,4,5-trisphosphate
  • Inositol 1,4,5-trisphosphate
88269-39-0

(2) Tocris Compounds for PLCE1 Gene

Compound Action Cas Number
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCE1: view

Transcripts for PLCE1 Gene

Unigene Clusters for PLCE1 Gene

Phospholipase C, epsilon 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCE1 Gene

No ASD Table

Relevant External Links for PLCE1 Gene

GeneLoc Exon Structure for
PLCE1
ECgene alternative splicing isoforms for
PLCE1

Expression for PLCE1 Gene

mRNA expression in normal human tissues for PLCE1 Gene

mRNA differential expression in normal tissues according to GTEx for PLCE1 Gene

This gene is overexpressed in Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for PLCE1 Gene

This gene is overexpressed in Adipocyte (47.2) and Heart (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLCE1 Gene



Protein tissue co-expression partners for PLCE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLCE1 Gene:

PLCE1

SOURCE GeneReport for Unigene cluster for PLCE1 Gene:

Hs.655033

mRNA Expression by UniProt/SwissProt for PLCE1 Gene:

Q9P212-PLCE1_HUMAN
Tissue specificity: Widely expressed. Isoform 1 is broadly expressed and only absent in peripheral blood leukocytes. Isoform 2 is specifically expressed in placenta, lung and spleen.
genes like me logo Genes that share expression patterns with PLCE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PLCE1 Gene

Orthologs for PLCE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLCE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLCE1 34
  • 88.85 (n)
  • 89.59 (a)
PLCE1 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCE1 34
  • 88.56 (n)
  • 90.33 (a)
PLCE1 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plce1 34
  • 84.79 (n)
  • 85.62 (a)
Plce1 16
Plce1 35
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLCE1 34
  • 99.45 (n)
  • 99.3 (a)
PLCE1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plce1 34
  • 84.66 (n)
  • 85.13 (a)
oppossum
(Monodelphis domestica)
Mammalia PLCE1 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 20 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 28 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
-- 35
  • 13 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC425224 34
  • 73.67 (n)
  • 73.85 (a)
PLCE1 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCE1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plce1 34
  • 73.69 (n)
  • 79.52 (a)
zebrafish
(Danio rerio)
Actinopterygii plce1 34
  • 65.67 (n)
  • 66.86 (a)
PLCE1 35
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea plc-1 34
  • 46.35 (n)
  • 35.88 (a)
plc-1 35
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLC1 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToOne
Species where no ortholog for PLCE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCE1 Gene

ENSEMBL:
Gene Tree for PLCE1 (if available)
TreeFam:
Gene Tree for PLCE1 (if available)

Paralogs for PLCE1 Gene

Paralogs for PLCE1 Gene

Pseudogenes.org Pseudogenes for PLCE1 Gene

genes like me logo Genes that share paralogs with PLCE1: view

Variants for PLCE1 Gene

Sequence variations from dbSNP and Humsavar for PLCE1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs121912605 Nephrotic syndrome 3 (NPHS3) 94,270,547(+) CATAT(C/T)GATTG reference, missense
rs17508082 - 94,132,372(+) CCGGT(A/T)CTCTC reference, missense
rs17417407 - 94,171,330(+) TTACC(A/G/T)CAGGG reference, missense
VAR_031845 -
rs3765524 - 94,298,541(+) ACTGA(C/T)CCAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLCE1 Gene

Variant ID Type Subtype PubMed ID
dgv485e59 CNV tandem duplication 20981092
esv1967938 CNV deletion 18987734
esv275010 CNV gain+loss 21479260
esv2761616 CNV gain 21179565
esv3415964 CNV duplication 20981092
esv3624247 CNV loss 21293372
esv3624248 CNV loss 21293372
esv3624249 CNV loss 21293372
nsv1127133 CNV deletion 24896259
nsv825525 CNV loss 20364138
nsv831946 CNV loss 17160897

Variation tolerance for PLCE1 Gene

Residual Variation Intolerance Score: 5.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.42; 99.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLCE1 Gene

Human Gene Mutation Database (HGMD)
PLCE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLCE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCE1 Gene

Disorders for PLCE1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for PLCE1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PLCE1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PLCE1_HUMAN
  • Nephrotic syndrome 3 (NPHS3) [MIM:610725]: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Most patients with NPHS3 show diffuse mesangial sclerosis on renal biopsy, which is a pathologic entity characterized by mesangial matrix expansion with no mesangial hypercellularity, hypertrophy of the podocytes, vacuolized podocytes, thickened basement membranes, and diminished patency of the capillary lumen. {ECO:0000269 PubMed:17086182}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PLCE1

Genetic Association Database (GAD)
PLCE1
Human Genome Epidemiology (HuGE) Navigator
PLCE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLCE1
genes like me logo Genes that share disorders with PLCE1: view

No data available for Genatlas for PLCE1 Gene

Publications for PLCE1 Gene

  1. A novel bifunctional phospholipase C that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway. (PMID: 11022047) Lopez I. … Lomasney J.W. (J. Biol. Chem. 2001) 2 3 4 65
  2. Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. (PMID: 11022048) Song C. … Kataoka T. (J. Biol. Chem. 2001) 2 3 4 65
  3. Genome-wide association study of personality traits in bipolar patients. (PMID: 21368711) Alliey-Rodriguez N. … Gershon E.S. (Psychiatr. Genet. 2011) 3 46 65
  4. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PMID: 21642993) Wu C. … Lin D. (Nat. Genet. 2011) 3 46 65
  5. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 46 65

Products for PLCE1 Gene

Sources for PLCE1 Gene