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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLCD4 Gene

protein-coding GIFtS: 59
GCID: GC02P219436

phospholipase C, delta 4

Explore 6 diseases affiliated with
PLCD4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase C, Delta 4¹ ²		PLC Delta4²
Phosphoinositide Phospholipase C-Delta-4² ³		PLC-Delta-4¹
EC 3.1.4.11³ ⁸		HPLCD4¹
1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-4²		Phospholipase C-Delta-4³
1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Delta-4²

External Ids:	HGNC: 9062¹	Entrez Gene: 84812²	Ensembl: ENSG00000115556⁷	OMIM: 605939⁵	UniProtKB: Q9BRC7³

Export aliases for PLCD4 gene to outside databases

Previous GC identifers: GC02U990230 GC02P218193 GC02P219675 GC02P219298 GC02P219180 GC02P211325

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLCD4:

This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role

in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second

messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer.

(provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: PLCD4_HUMAN, Q9BRC7

Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules

diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC),

while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization,

probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome

reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC.

Overexpression up-regulates the Erk signaling pathway and proliferation

summary for PLCD4:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the

hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and

1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily

activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth

factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological

functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane

phospholipids.

Gene Wiki entry for PLCD4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLCD4 gene promoter:
c-Fos AP-1 STAT5A c-Jun ATF6 C/EBPalpha GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLCD4 promoter sequence

Search SABiosciences Chromatin IP Primers for PLCD4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCD4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35

PLCD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCD4 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P219436: view genomic region (about GC identifiers)

Start:	219,472,488 bp from pter	End:	219,501,907 bp from pter
Size:	29,420 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLCD4_HUMAN, Q9BRC7 (See protein sequence)

Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

Size: 762 amino acids; 87585 Da

Cofactor: Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain (By similarity)

Subunit: Interacts with GRIP1 (By similarity)

Subcellular location: Membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Cytoplasm.

Endoplasmic reticulum (By similarity). Note=Localizes primarily to intracellular membranes mostly to the endoplasmic

reticulum

Secondary accessions: Q53FS8

Alternative splicing: 2 isoforms: Q9BRC7-1 Q9BRC7-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for PLCD4: NX_Q9BRC7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BRC7

4/32 DME Specific Peptides for PLCD4 (Q9BRC7) (see all 32)

SIVDPLV

DTARQET

NQDGKMS

VDPLVKV

PLCD4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_116115.1

ENSEMBL proteins:

ENSP00000388631 ENSP00000415725 ENSP00000406040 ENSP00000396942 ENSP00000391850

ENSP00000396185 ENSP00000403935 ENSP00000404481

Human Recombinant Protein Products:

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	Novus Biologicals PLCD4 Proteins Novus Biologicals PLCD4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0016020	membrane	IEA	--

PLCD4 for ontologies About GeneDecksing

PLCD4 Antibody Products:

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	Novus Biologicals PLCD4 Antibodies
	Search for Antibodies for PLCD4 at Abcam
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Assay Products for PLCD4:

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	GenScript Custom Assay Services for PLCD4
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLCD4 for domains About GeneDecksing

5/13 InterPro domains/families (see all 13):

IPR015359 PLipase_C_EF-hand-like

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR001192 Pinositol_PLipase_C

IPR001849 Pleckstrin_homology

Graphical View of Domain Structure for InterPro Entry Q9BRC7

ProtoNet protein and cluster: Q9BRC7

3 Blocks protein families:

IPB000008 C2 domain

IPB000909 Phosphatidylinositol-specific phospholipase C

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: PLCD4_HUMAN, Q9BRC7

Domain: The PDZ-binding motif mediates the interaction with GRIP1

Domain: The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective

Ca(2+)-mediated targeting to various cellular membranes

Domain: The PH domain is not a critical determinant of the membrane localization

Similarity: Contains 1 C2 domain

Similarity: Contains 3 EF-hand domains

Similarity: Contains 1 PH domain

Similarity: Contains 1 PI-PLC X-box domain

Similarity: Contains 1 PI-PLC Y-box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PLCD4_HUMAN, Q9BRC7

Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules

diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC),

while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization,

probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome

reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC.

Overexpression up-regulates the Erk signaling pathway and proliferation

Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate +

diacylglycerol

Genatlas biochemistry entry for PLCD4:

phospholipase C,delta 4,involved in signal transduction

Enzyme Number (IUBMB): EC 3.1.4.11¹ ²

miRNA Products:		OriGene 3'-UTR Clone: PLCD4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCD4
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCD4:
		hsa-miR-623 hsa-miR-2117 hsa-miR-3915 hsa-miR-143* hsa-miR-1224-5p hsa-miR-455-3p
		SwitchGear 3'UTR luciferase reporter plasmid: PLCD4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for PLCD4

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCD4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphatidylinositol phospholipase C activity	IEA	--
GO:0004871	signal transducer activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005543	phospholipid binding	IEA	--

PLCD4 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Plcd4^tm1Kfu for PLCD4
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Plcd4):

reproductive system

PLCD4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sweet Taste Signaling

	Sweet Taste Signaling	1.00			Cellular Effects of Sildenafil	0.46
	Melatonin Signaling	0.72			Sperm Motility	0.36

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

CREB Pathway

	CREB Pathway	1.00			Activation of PKC through GPCR	0.63
	IP3 Pathway	0.68			Intracellular Calcium Signaling	0.50

NFAT and Cardiac Hypertrophy

	NFAT and Cardiac Hypertrophy	1.00			IGF1R Signaling	0.37
	Signaling Involved in Cardiac Hypertrophy	0.42

Inositol phosphate metabolism

	Inositol phosphate metabolism	1.00			Phosphatidylinositol signaling system	0.59
	superpathway of inositol phosphate compounds	0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PLCD4

Anandamide biosynthesis and metabolism

5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLCD4 (see all 38)

	Antioxidant Action of Vitamin-C
	Intracellular Calcium Signaling
	Aldosterone Signaling in Epithelial Cells
	UVA-Induced MAPK Signaling
	PACAP Signaling

1 GeneGo (Thomson Reuters) Pathway for PLCD4

Anandamide biosynthesis and metabolism

4 BioSystems Pathways for PLCD4

	D-myo-inositol-5-phosphate metabolism
	D-myo-inositol (1,4,5)-trisphosphate biosynthesis
	phospholipases
	superpathway of inositol phosphate compounds

1 PharmGKB Pathway for PLCD4

Proton Pump Inhibitor Pathway, Pharmacodynamics

4 Kegg Pathways (Kegg details for PLCD4):

	Inositol phosphate metabolism
	Metabolic pathways
	Calcium signaling pathway
	Phosphatidylinositol signaling system

PLCD4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PLCD4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/71 Interacting proteins for PLCD4 (Q9BRC7^{2, 3} ENSP00000388631⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 71)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IPO11	Q9UI26²^,³, ENSP00000386992⁴	MINT-67854 I2D: score=5 STRING: ENSP00000386992
TRIM39	Q9HCM9²^,³, ENSP00000365844⁴	MINT-67359 I2D: score=5 STRING: ENSP00000365844
IPMK	ENSP00000363046⁴	STRING: ENSP00000363046
ITPR3	ENSP00000363435⁴	STRING: ENSP00000363435
PI4KB	ENSP00000271657⁴	STRING: ENSP00000271657

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	--	--
GO:0007340	acrosome reaction	IEA	--
GO:0016042	lipid catabolic process	IEA	--
GO:0035556	intracellular signal transduction	IEA	--

PLCD4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for PLCD4:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLCD4 available from Tocris Bioscience About this table

Compound	Action	CAS #
m-3M3FBS	Phospholipase C activator	[200933-14-8]
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
U 73122	Phospholipase C inhibitor	[112648-68-7]
D609	Selective PC-PLC inhibitor	[83373-60-8]

10/1226 HMDB Compounds for PLCD4 (see all 1226) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
1-Phosphatidyl-D-myo-inositol	1-Phosphatidyl-1D-myo-inositol (see all 6)	--	--
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--

Search CenterWatch for drugs/clinical trials and news about PLCD4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLCD4 gene:

NM_032726.3

Unigene Cluster for PLCD4:

Phospholipase C, delta 4

Hs.632528 [show with all ESTs]

Unigene Representative Sequence: NM_032726

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000450993(uc021vww.1 uc021vwx.1) ENST00000483685(uc010zkk.1)

ENST00000444453 ENST00000446503 ENST00000469493 ENST00000473443 ENST00000465713

ENST00000417849 ENST00000415854 ENST00000432688 ENST00000459791(uc002vik.1)

ENST00000497482 ENST00000458239 ENST00000484718 ENST00000457773

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCD4
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCD4:
		hsa-miR-623 hsa-miR-2117 hsa-miR-3915 hsa-miR-143* hsa-miR-1224-5p hsa-miR-455-3p
		SwitchGear 3'UTR luciferase reporter plasmid: PLCD4 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCD4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLCD4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLCD4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCD4

Additional cDNA sequence:

AK057186.1 AK223203.1 AK297808.1 AK299458.1 BC006355.2

9 DOTS entries:

DT.70104504 DT.95348745 DT.432767 DT.40232417 DT.120959240 DT.100759729 DT.97768474 DT.92419730

DT.95362506

24/43 AceView cDNA sequences (see all 43):

BC006355 NM_032726 BE046870 AW594023 AY512961 AU130385 AI968895 BQ640540

BF206866 BP361394 AK023083 BP341990 AI203283 BQ638864 AL712992 AL712977

AI366170 BX491275 BQ640339 AI914254 AA359449 BF310672 AL706730 AK057186

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PLCD4 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	·	13c	·	13d	^	14	^	15a	·
SP1:							-		-														-								-		-														-
SP2:							-		-						-										-						-		-
SP3:							-		-														-						-		-		-		-		-
SP4:							-		-														-
SP5:																																									-		-		-		-

ExUns:	15b	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b
SP1:			-						-
SP2:			-						-
SP3:			-						-
SP4:
SP5:

ECgene alternative splicing isoforms for PLCD4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLCD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACAAGGTT

About this image
See PLCD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLCD4

SOURCE GeneReport for Unigene cluster: Hs.632528

UniProtKB/Swiss-Prot: PLCD4_HUMAN, Q9BRC7

Tissue specificity: Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue.

Expressed in corneal epithelial cells

SABiosciences Custom PCR Arrays for PLCD4

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCD4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCD4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCD4 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC424214¹	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase more	67.67(n) 62.7(a)		424214 XM_422063.3 XP_422063.3
lizard (Anolis carolinensis)	Reptilia	PLCD4⁶	--	58(a)	1 ↔ 1	1(88393446-88412336)
zebrafish (Danio rerio)	Actinopterygii	plcd4a¹	phospholipase C, delta 4a	62.34(n) 59.13(a)		565669 XM_688936.3 XP_694028.3
worm (Caenorhabditis elegans)	Secernentea	plc-4⁶	PhosphoLipase C family member (plc-4)	30(a)	possible ortholog	IV(7509454-7512662)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	PLC1¹	Plc1p	43.9(n) 35.9(a)		855860 NP_015055.1
thale cress (Arabidopsis thaliana)	eudicotyledons	ATPLC1⁶ ATPLC2⁶ (see all 9)	phosphoinositide phospholipase C 2 (see all 9)	26(a) 26(a) (see all 9)	many ↔ many many ↔ many (see all 9)	5(23704231-23706800) 3(2582362-2585851)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	phospholipase C, putative, expressed (see all 4)	27(a) 25(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(10024184-10026867) 12(23015165-23019784)

ENSEMBL Gene Tree for PLCD4 (if available)
TreeFam Gene Tree for PLCD4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PLCD4 gene

PLCG2² PLCD1² PLCG1² PLCB2² PLCZ1² PLCB3² PLCH1² PLCD3²

PLCB1² PLCB4² PLCH2² PLCL1² PLCL2²

12 SIMAP similar genes for PLCD4 using alignment to 6 protein entries: PLCD4_HUMAN (see all proteins):

DKFZp686K101 PLCD1 PLCD3 PLCZ1 PLCL1 PLCL2

PLCH2 FLJ00414 PLCB1 PLCB4 PLCH1 PLCB2

PLCD4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142039845^1,2		--	219470515(+)	`CCTCC-/CTCT GTTTC`	1	--	us2k¹		0	--	--	--	--
rs115119550^1,2		--	219470619(+)	`TATGGG/ACTGAA`	1	--	us2k¹		1		WA	118
rs183069535^1,2		--	219470858(+)	`GTTGGA/GGAAGT`	1	--	us2k¹		0	--	--	--	--
rs149829231^1,2		--	219470895(+)	`TAAAAC/TAGGGC`	1	--	us2k¹		0	--	--	--	--
rs7562588^1,2	C,F,	--	219471094(+)	`GACCTT/CAGGAT`	1	--	us2k¹		3		WA CSA	122
rs186678162^1,2		--	219471113(+)	`TAAAAA/TATTAT`	1	--	us2k¹		0	--	--	--	--
rs191445340^1,2		--	219471135(+)	`TGGGTA/GCAGTG`	1	--	us2k¹		0	--	--	--	--
rs7575249^1,2	C,F,A,H,	--	219471284(+)	`CATGCG/ACCTGT`	1	--	us2k¹		6		NA WA CSA	12
rs9679018^1,2	C,	--	219471351(+)	`ggttgC/Tagtaa`	1	--	us2k¹		1		WA	2
rs184759693^1,2		--	219471367(+)	`GATCAC/TGCCAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLCD4 (219472488 - 219501907 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PLCD4: --
Human Gene Mutation Database (HGMD): PLCD4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLCD4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLCD4 for disorders           About GeneDecksing

OMIM gene information: 605939    OMIM disorders: --

6 diseases for PLCD4:    About MalaCards

neurologic diseases immunodeficiency neuronitis huntington's disease

glioblastoma breast cancer

Human Genome Epidemiology (HuGE) Navigator: PLCD4 (6 documents)

Export disorders for PLCD4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLCD4 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with PLCD4)

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Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization. (PubMed id 10702683)^{1, 2, 3, 9} Kim H.... Park S.H. (1999)
Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells. (PubMed id 15140260)^{1, 2, 9} Leung D.W.... Singer J.W. (2004)
The ins and outs of HIV-1 Tat. (PubMed id 21951552)¹ Debaisieux S....Beaumelle B. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)¹ Segat L....Crovella S. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)¹ GratacA^s M....Carracedo A. (2008)
Identification and analysis of the promoter region of the human PLC-delta4 gene. (PubMed id 17394098)¹ Chae S.W....Rha H.K. (2007)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84812	HGNC: 9062	AceView: PLCD4	Ensembl:ENSG00000115556	euGenes: HUgn84812
ECgene: PLCD4	Kegg: 84812	H-InvDB: PLCD4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PLCD4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PLCD4 gene
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Patent Information for PLCD4 gene:
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phospholipase C, delta 4

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