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PLCD4 Gene

protein-coding   GIFtS: 60
GCID: GC02P219473

Phospholipase C, Delta 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase C, Delta 41 2     PLC Delta42
Phosphoinositide Phospholipase C-Delta-42 3     PLC-delta-43
EC 3.1.4.113 8     hPLCD43
1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-42     Phospholipase C-Delta-43
1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Delta-42     

External Ids:    HGNC: 90621   Entrez Gene: 848122   Ensembl: ENSG000001155567   OMIM: 6059395   UniProtKB: Q9BRC73   

Export aliases for PLCD4 gene to outside databases

Previous GC identifers: GC02U990230 GC02P218193 GC02P219436 GC02P219675 GC02P219298 GC02P219180 GC02P211325


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLCD4 Gene:
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical
role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular
second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for
cancer. (provided by RefSeq, Jan 2011)

GeneCards Summary for PLCD4 Gene:
PLCD4 (phospholipase C, delta 4) is a protein-coding gene. GO annotations related to this gene include signal transducer activity and calcium ion binding. An important paralog of this gene is PLCD1.

UniProtKB/Swiss-Prot: PLCD4_HUMAN, Q9BRC7
Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules
diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C
(PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during
fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona
pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in
cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation

summary for PLCD4 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLCD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLCD4 gene promoter:
         c-Fos   AP-1   STAT5A   c-Jun   ATF6   C/EBPalpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCD4 promoter sequence
   Search Chromatin IP Primers for PLCD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

PLCD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCD4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219473:  view genomic region     (about GC identifiers)

Start:
219,472,488 bp from pter      End:
219,501,909 bp from pter
Size:
29,422 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLCD4_HUMAN, Q9BRC7 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4  
Size: 762 amino acids; 87585 Da
Cofactor: Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain (By similarity)
Subunit: Interacts with GRIP1 (By similarity)
Secondary accessions: Q53FS8
Alternative splicing: 2 isoforms:  Q9BRC7-1   Q9BRC7-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for PLCD4: NX_Q9BRC7

Explore proteomics data for PLCD4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PLCD4 (Q9BRC7) (see all 32)
     SIVDPLV  DTARQET  NQDGKMS  VDPLVKV 


    See PLCD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116115.1  
    ENSEMBL proteins: 
     ENSP00000388631   ENSP00000415725   ENSP00000406040   ENSP00000396942   ENSP00000391850  
     ENSP00000396185   ENSP00000403935   ENSP00000404481  

    PLCD4 Human Recombinant Protein Products:

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    Novus Biologicals PLCD4 Proteins
    Novus Biologicals PLCD4 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PLCD4 

     
    antibodies-online proteins for PLCD4 (7 products) 

     
    antibodies-online peptides for PLCD4

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    antibodies-online antibodies for PLCD4 (9 products) 

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    antibodies-online kits for PLCD4 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: PLCdelta4
    Phosphoinositide-specific phospholipase C

    Selected InterPro protein domains (see all 12):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR001192 PI-PLC_fam
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q9BRC7

    ProtoNet protein and cluster: Q9BRC7

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PLCD4_HUMAN, Q9BRC7
    Domain: The PDZ-binding motif mediates the interaction with GRIP1
    Domain: The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective
    Ca(2+)-mediated targeting to various cellular membranes
    Domain: The PH domain is not a critical determinant of the membrane localization
    Similarity: Contains 1 C2 domain
    Similarity: Contains 3 EF-hand domains
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain


    Find genes that share domains with PLCD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCD4_HUMAN, Q9BRC7
    Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules
    diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C
    (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during
    fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona
    pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in
    cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
    + diacylglycerol

         Genatlas biochemistry entry for PLCD4:
    phospholipase C,delta 4,involved in signal transduction

         Enzyme Number (IUBMB): EC 3.1.4.111 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IEA--
    GO:0004629phospholipase C activity ----
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PLCD4           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Plcd4):
     reproductive system 

    Find genes that share phenotypes with PLCD4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Plcd4tm1Kfu for PLCD4

       genOway: Develop your customized and physiologically relevant rodent model for PLCD4

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate PLCD4:
    hsa-miR-623 hsa-miR-2117 hsa-miR-3915 hsa-miR-143* hsa-miR-1224-5p hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLCD4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLCD4

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCD4

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLCD4_HUMAN, Q9BRC7: Membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Cytoplasm.
    Endoplasmic reticulum (By similarity). Note=Localizes primarily to intracellular membranes mostly to the
    endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endoplasmic reticulum2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with PLCD4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLCD4 About   (see all 29)  
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.36
    Phosphatidylinositol signaling system0.61
    D-myo-inositol-5-phosphate metabolism0.00
    superpathway of inositol phosphate compounds0.60
    2phospholipases
    phospholipases0.34
    Anandamide biosynthesis and metabolism0.34
    3Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Cellular Effects of Sildenafil0.46
    Melatonin Signaling0.72
    Sperm Motility0.37
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    5CREB Pathway
    CREB Pathway0.68
    Activation of PKC through GPCR0.63
    IP3 Pathway0.68
    Intracellular Calcium Signaling0.50


    Find genes that share SuperPaths with PLCD4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLCD4 (see all 38)
        Antioxidant Action of Vitamin-C
    Intracellular Calcium Signaling
    Aldosterone Signaling in Epithelial Cells
    UVA-Induced MAPK Signaling
    PACAP Signaling

    1 GeneGo (Thomson Reuters) Pathway for PLCD4
        Anandamide biosynthesis and metabolism

    4 BioSystems Pathways for PLCD4
        D-myo-inositol-5-phosphate metabolism
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis
    phospholipases
    superpathway of inositol phosphate compounds

    1 PharmGKB Pathway for PLCD4
        Proton Pump Inhibitor Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for PLCD4):
        Inositol phosphate metabolism
    Metabolic pathways
    Calcium signaling pathway
    Phosphatidylinositol signaling system
    Thyroid hormone signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLCD4
    Interactions:

        Search GeneGlobe Interaction Network for PLCD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLCD4 (Q9BRC72, 3 ENSP000003886314) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224994Q9HCM92, 3, ENSP000004119494MINT-67359 I2D: score=5 STRING: ENSP00000411949
    ENSG00000232839Q9HCM92, 3, ENSP000003983554MINT-67359 I2D: score=5 STRING: ENSP00000398355
    ENSG00000206495Q9HCM92, 3MINT-67359 I2D: score=5 
    ENSG00000226437Q9HCM92, 3MINT-67359 I2D: score=5 
    ENSG00000229929Q9HCM92, 3MINT-67359 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0007165signal transduction ----
    GO:0007340acrosome reaction IEA--
    GO:0016042lipid catabolic process IEA--
    GO:0035556intracellular signal transduction IEA--

    Find genes that share ontologies with PLCD4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for PLCD4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLCD4 (see all 1226)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLCD4 gene: 
    NM_032726.3  

    Unigene Cluster for PLCD4:

    Phospholipase C, delta 4
    Hs.632528  [show with all ESTs]
    Unigene Representative Sequence: NM_032726
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450993(uc021vww.1 uc021vwx.1) ENST00000483685(uc010zkk.1)
    ENST00000444453 ENST00000446503 ENST00000469493 ENST00000473443 ENST00000465713
    ENST00000417849 ENST00000415854 ENST00000432688 ENST00000459791(uc002vik.1)
    ENST00000497482 ENST00000458239 ENST00000484718 ENST00000457773
    miRNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PLCD4
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      QuantiFast Probe-based Assays in human, mouse, rat PLCD4

    Additional mRNA sequence: 

    AK057186.1 AK223203.1 AK297808.1 AK299458.1 BC006355.2 

    9 DOTS entries:

    DT.70104504  DT.95348745  DT.432767  DT.40232417  DT.120959240  DT.100759729  DT.97768474  DT.92419730 
    DT.95362506 

    Selected AceView cDNA sequences (see all 43):

    AU130385 BE046870 AW594023 AI968895 BC006355 AY512961 NM_032726 BQ640540 
    AL712992 BX491275 BP341990 AK023083 AL712977 BF206866 BP361394 BQ640339 
    BQ638864 AI914254 AI366170 AA359449 AI203283 AL706730 BF310672 AK057186 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLCD4 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a ·
    SP1:                    -     -                                         -                       -     -                                         -               
    SP2:                    -     -                 -                             -                 -     -                                                         
    SP3:                    -     -                                         -                 -     -     -     -     -                                             
    SP4:                    -     -                                         -                                                                                       
    SP5:                                                                                                                          -     -     -     -               

    ExUns: 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
    SP1:        -                 -               
    SP2:        -                 -               
    SP3:        -                 -               
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for PLCD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PLCD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACAAGGTT
    PLCD4 Expression
    About this image


    PLCD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Thalamus
     
     Neural Tube (Nervous System)
             Diencephalon
     
     Skeletal Muscle (Muscoskeletal System)
    PLCD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLCD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632528

    UniProtKB/Swiss-Prot: PLCD4_HUMAN, Q9BRC7
    Tissue specificity: Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal
    tissue. Expressed in corneal epithelial cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PLCD4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcd41 , 5 phospholipase C, delta 41, 5 79.15(n)1
    74.51(a)1
      1 (38.54 cM)5
    188021  NM_001081456.11  NP_001074925.11 
     745428885 
    chicken
    (Gallus gallus)
    Aves LOC4242141 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase more 67.12(n)
    61.59(a)
      424214  XM_004942870.1  XP_004942927.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLCD46
    phospholipase C, delta 4
    58(a)
    1 ↔ 1
    1(88390812-88412477)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia plcd41 phospholipase C, delta 4 63.64(n)
    60.08(a)
      100379715  XM_004917630.1  XP_004917687.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plcd4a1 phospholipase C, delta 4a 61.99(n)
    58.76(a)
      565669  XM_688936.4  XP_694028.4 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PLC11 PLC1 43.92(n)
    35.59(a)
      855860   NP_015055.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PLC41 PLC4 45.12(n)
    36.51(a)
      835984  NM_125257.2  NP_200678.2 


    ENSEMBL Gene Tree for PLCD4 (if available)
    TreeFam Gene Tree for PLCD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLCD4 gene
    PLCD12  PLCB22  PLCZ12  PLCH12  PLCB32  PLCD32  PLCH22  PLCB12  
    PLCB42  PLCL22  PLCL12  
    12 SIMAP similar genes for PLCD4 using alignment to 6 protein entries:     PLCD4_HUMAN (see all proteins):
    DKFZp686K101    PLCD1    PLCD3    PLCZ1    PLCL1    PLCL2
    PLCH2    FLJ00414    PLCB1    PLCB4    PLCH1    PLCB2

    Find genes that share paralogs with PLCD4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLCD4 (see all 576)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420398451,2
    C--219470515(+) CCTCC-/CTCT  
            
    GTTTC
    1 -- us2k10--------
    rs1151195501,2
    F--219470619(+) TATGGG/ACTGAA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1830695351,2
    --219470858(+) GTTGGA/GGAAGT 1 -- us2k10--------
    rs1498292311,2
    --219470895(+) TAAAAC/TAGGGC 1 -- us2k10--------
    rs75625881,2
    C,F--219471094(+) GACCTT/CAGGAT 1 -- us2k13Minor allele frequency- C:0.21WA CSA 122
    rs1866781621,2
    --219471113(+) TAAAAA/TATTAT 1 -- us2k10--------
    rs1914453401,2
    --219471135(+) TGGGTA/GCAGTG 1 -- us2k10--------
    rs75752491,2
    C,F,A,H--219471284(+) CATGCG/ACCTGT 1 -- us2k16Minor allele frequency- A:0.17NA WA CSA 12
    rs96790181,2
    C,F--219471351(+) ggttgC/Tagtaa 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1847596931,2
    --219471367(+) GATCAC/TGCCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLCD4 (219472488 - 219501909 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PLCD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875862CNV Gain21882294

    Human Gene Mutation Database (HGMD): PLCD4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLCD4
    DNA2.0 Custom Variant and Variant Library Synthesis for PLCD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605939    OMIM disorders: --


    Find genes that share disorders with PLCD4           About GenesLikeMe

    Genetic Association Database (GAD): PLCD4
    Human Genome Epidemiology (HuGE) Navigator: PLCD4 (6 documents)

    Export disorders for PLCD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLCD4 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with PLCD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization. (PubMed id 10702683)1, 2, 3, 9 Kim H.... Park S.H. (Cytogenet. Cell Genet. 1999)
    2. Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells. (PubMed id 15140260)1, 2, 9 Leung D.W.... Singer J.W. (Mol. Cancer 2004)
    3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. The ins and outs of HIV-1 Tat. (PubMed id 21951552)1 Debaisieux S....Beaumelle B. (Traffic 2012)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    9. Identification and analysis of the promoter region of the human PLC-delta4 gene. (PubMed id 17394098)1 Chae S.W....Rha H.K. (Mol. Biol. Rep. 2007)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84812 HGNC: 9062 AceView: PLCD4 Ensembl:ENSG00000115556 euGenes: HUgn84812
    ECgene: PLCD4 Kegg: 84812 H-InvDB: PLCD4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLCD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLCD4 gene:
    Search GeneIP for patents involving PLCD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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