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Aliases for PLCD4 Gene

Aliases for PLCD4 Gene

  • Phospholipase C, Delta 4 2 3
  • EC 3.1.4.11 4 64
  • Phosphoinositide Phospholipase C-Delta-4 4
  • Phospholipase C-Delta-4 4
  • PLC-Delta-4 4
  • HPLCD4 4

External Ids for PLCD4 Gene

Summaries for PLCD4 Gene

Entrez Gene Summary for PLCD4 Gene

  • This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]

GeneCards Summary for PLCD4 Gene

PLCD4 (Phospholipase C, Delta 4) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include calcium ion binding and signal transducer activity. An important paralog of this gene is PLCH1.

UniProtKB/Swiss-Prot for PLCD4 Gene

  • Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Tocris Summary for PLCD4 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLCD4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCD4 Gene

Genomics for PLCD4 Gene

Genomic Location for PLCD4 Gene

Start:
218,607,765 bp from pter
End:
218,637,186 bp from pter
Size:
29,422 bases
Orientation:
Plus strand

Genomic View for PLCD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLCD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCD4 Gene

Regulatory Elements for PLCD4 Gene

Proteins for PLCD4 Gene

  • Protein details for PLCD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRC7-PLCD4_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
    Protein Accession:
    Q9BRC7
    Secondary Accessions:
    • Q53FS8

    Protein attributes for PLCD4 Gene

    Size:
    762 amino acids
    Molecular mass:
    87585 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.;
    Quaternary structure:
    • Interacts with GRIP1.

    Alternative splice isoforms for PLCD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCD4 Gene

Proteomics data for PLCD4 Gene at MOPED

Post-translational modifications for PLCD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PLCD4 Gene

Gene Families for PLCD4 Gene

HGNC:
  • EFHAND :EF-hand domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

PLCD4_HUMAN
Domain:
  • The PDZ-binding motif mediates the interaction with GRIP1:
    • Q9BRC7
  • The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes:
    • Q9BRC7
  • The PH domain is not a critical determinant of the membrane localization:
    • Q9BRC7
  • Contains 1 C2 domain.:
    • Q9BRC7
  • Contains 3 EF-hand domains.:
    • Q9BRC7
  • Contains 1 PH domain.:
    • Q9BRC7
  • Contains 1 PI-PLC X-box domain.:
    • Q9BRC7
  • Contains 1 PI-PLC Y-box domain.:
    • Q9BRC7
genes like me logo Genes that share domains with PLCD4: view

Function for PLCD4 Gene

Molecular function for PLCD4 Gene

GENATLAS Biochemistry: phospholipase C,delta 4,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
UniProtKB/Swiss-Prot Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Enzyme Numbers (IUBMB) for PLCD4 Gene

Gene Ontology (GO) - Molecular Function for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004629 phospholipase C activity --
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PLCD4: view

Phenotypes for PLCD4 Gene

MGI mutant phenotypes for PLCD4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PLCD4: view

Animal Models for PLCD4 Gene

MGI Knock Outs for PLCD4:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PLCD4 Gene

Localization for PLCD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCD4 Gene

Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCD4 Gene COMPARTMENTS Subcellular localization image for PLCD4 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with PLCD4: view

Pathways for PLCD4 Gene

genes like me logo Genes that share pathways with PLCD4: view

Gene Ontology (GO) - Biological Process for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0007165 signal transduction --
GO:0007340 acrosome reaction IEA --
GO:0016042 lipid catabolic process IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PLCD4: view

Compounds for PLCD4 Gene

(5) Tocris Compounds for PLCD4 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
FIPI Phospholipase D inhibitor [939055-18-2]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]

(1226) HMDB Compounds for PLCD4 Gene

Compound Synonyms Cas Number PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
genes like me logo Genes that share compounds with PLCD4: view

Transcripts for PLCD4 Gene

Unigene Clusters for PLCD4 Gene

Phospholipase C, delta 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6:
SP7: -
SP8:
SP9: -
SP10:

ExUns: 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PLCD4 Gene

GeneLoc Exon Structure for
PLCD4
ECgene alternative splicing isoforms for
PLCD4

Expression for PLCD4 Gene

mRNA expression in normal human tissues for PLCD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCD4 Gene

This gene is overexpressed in Muscle - Skeletal (13.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLCD4 Gene

SOURCE GeneReport for Unigene cluster for PLCD4 Gene Hs.632528

mRNA Expression by UniProt/SwissProt for PLCD4 Gene

Q9BRC7-PLCD4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells.
genes like me logo Genes that share expressions with PLCD4: view

Orthologs for PLCD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCD4 36
  • 99.39 (n)
  • 99.21 (a)
PLCD4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLCD4 36
  • 85.72 (n)
  • 82.39 (a)
PLCD4 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCD4 36
  • 86.47 (n)
  • 84.1 (a)
PLCD4 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcd4 36
  • 79.15 (n)
  • 74.51 (a)
Plcd4 16
Plcd4 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLCD4 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcd4 36
  • 79.59 (n)
  • 73.59 (a)
chicken
(Gallus gallus)
Aves LOC424214 36
  • 67.12 (n)
  • 61.59 (a)
PLCD4 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCD4 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plcd4 36
  • 63.64 (n)
  • 60.08 (a)
zebrafish
(Danio rerio)
Actinopterygii plcd4a 36
  • 61.99 (n)
  • 58.76 (a)
plcd4a 37
  • 58 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR024W 36
  • 45.14 (n)
  • 33.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLC1 36
  • 43.92 (n)
  • 35.59 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D00638g 36
  • 46.26 (n)
  • 35.69 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PLC4 36
  • 45.12 (n)
  • 36.51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01266 36
  • 46.89 (n)
  • 40.3 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes plc1 36
  • 44.49 (n)
  • 35.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToMany
Species with no ortholog for PLCD4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLCD4 Gene

ENSEMBL:
Gene Tree for PLCD4 (if available)
TreeFam:
Gene Tree for PLCD4 (if available)

Paralogs for PLCD4 Gene

Paralogs for PLCD4 Gene

Selected SIMAP similar genes for PLCD4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PLCD4: view

Variants for PLCD4 Gene

Sequence variations from dbSNP and Humsavar for PLCD4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs485765 -- 218,616,081(+) ATAGT(C/G)GGGGG intron-variant
rs489321 -- 218,621,904(+) GAAAC(A/C)CCCGT intron-variant
rs591573 -- 218,613,470(+) ATATA(C/T)TTCTA intron-variant
rs611203 -- 218,607,602(+) CAGCC(A/G)TATTA upstream-variant-2KB
rs658378 -- 218,619,158(+) TGATA(A/T)AAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCD4 Gene

Variant ID Type Subtype PubMed ID
nsv875862 CNV Gain 21882294

Relevant External Links for PLCD4 Gene

HapMap Linkage Disequilibrium report
PLCD4
Human Gene Mutation Database (HGMD)
PLCD4

Disorders for PLCD4 Gene

Relevant External Links for PLCD4

Genetic Association Database (GAD)
PLCD4
Human Genome Epidemiology (HuGE) Navigator
PLCD4
genes like me logo Genes that share disorders with PLCD4: view

No data available for UniProtKB/Swiss-Prot for PLCD4 Gene

Publications for PLCD4 Gene

  1. Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization. (PMID: 10702683) Kim H. … Park S.H. (Cytogenet. Cell Genet. 1999) 2 3 4 23
  2. Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells. (PMID: 15140260) Leung D.W. … Singer J.W. (Mol. Cancer 2004) 3 4 23
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 49
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 49
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49

Products for PLCD4 Gene

Sources for PLCD4 Gene

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