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Aliases for PLCD4 Gene

Aliases for PLCD4 Gene

  • Phospholipase C Delta 4 2 3 5
  • EC 3.1.4.11 4 61
  • Phosphoinositide Phospholipase C-Delta-4 4
  • Phospholipase C, Delta 4 2
  • Phospholipase C-Delta-4 4
  • PLC-Delta-4 4
  • HPLCD4 4

External Ids for PLCD4 Gene

Previous GeneCards Identifiers for PLCD4 Gene

  • GC02U990230
  • GC02P218193
  • GC02P219436
  • GC02P219675
  • GC02P219298
  • GC02P219180
  • GC02P211325
  • GC02P219473

Summaries for PLCD4 Gene

Entrez Gene Summary for PLCD4 Gene

  • This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]

GeneCards Summary for PLCD4 Gene

PLCD4 (Phospholipase C Delta 4) is a Protein Coding gene. Among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics and Phospholipase-C Pathway. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCD3.

UniProtKB/Swiss-Prot for PLCD4 Gene

  • Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Tocris Summary for PLCD4 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCD4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCD4 Gene

Genomics for PLCD4 Gene

Regulatory Elements for PLCD4 Gene

Enhancers for PLCD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G218566 1.8 FANTOM5 ENCODE dbSUPER 21.5 -38.4 -38448 4.7 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC CNOT9 PLCD4 BCS1L USP37 SLC23A3 NHEJ1 AAMP ZNF142 RNF25 CNPPD1
GH02G218730 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.4 +124.9 124925 4.6 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SLC11A1 CYP27A1 PLCD4 USP37 NHEJ1 RNF25 BCS1L ZNF142 AAMP PNKD
GH02G218743 1.5 Ensembl ENCODE dbSUPER 19.2 +137.3 137319 3.6 HDGF PKNOX1 ATF1 CREB3L1 ARNT ARID4B DMAP1 NCOA1 JUNB MIER2 CYP27A1 PLCD4 TTLL4 PRKAG3 STK36 RNF25 GC02P218766
GH02G218781 1.6 FANTOM5 Ensembl ENCODE 17.2 +175.8 175849 6.0 ATF1 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 FOS CYP27A1 PLCD4 TTLL4 PRKAG3 PNKD SLC11A1 RNF25 TMBIM1 ENSG00000272555
GH02G218443 1.1 ENCODE 21.5 -161.9 -161930 4.1 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 CNOT9 PLCD4 RETREG2 USP37 VIL1 RN7SKP38
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLCD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCD4 Gene

Chromosome:
2
Start:
218,607,765 bp from pter
End:
218,637,186 bp from pter
Size:
29,422 bases
Orientation:
Plus strand

Genomic View for PLCD4 Gene

Genes around PLCD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCD4 Gene

Proteins for PLCD4 Gene

  • Protein details for PLCD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRC7-PLCD4_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
    Protein Accession:
    Q9BRC7
    Secondary Accessions:
    • Q53FS8

    Protein attributes for PLCD4 Gene

    Size:
    762 amino acids
    Molecular mass:
    87585 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with GRIP1.

    Alternative splice isoforms for PLCD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCD4 Gene

Selected DME Specific Peptides for PLCD4 Gene

Q9BRC7:
  • FYEISSFSE
  • SSFSETKA
  • PLNHYFI
  • GYRHIHLLS
  • DTARQET
  • NQDGKMS
  • GYVLKPDFLRD
  • AKPSFSISDV
  • DGFLSYLCS
  • QERLDQWLSDWFQRGDKNQDG
  • HLTEILGEQLLSTTLDG
  • CGYVLKP
  • CLPIYQDMTQPL
  • SIVDPLV
  • TDQDLLLMQEG
  • DYDWKSRNDF
  • GCQMVAMNMQTAG
  • SGTLEGEEFV
  • LMNVEMD
  • MRKVRSKSWKKLR
  • DGMTVWH
  • SSHNTYL
  • EGYIRALKRGCRCVEVD
  • SGKLRHVLSMDGFL
  • VDPLVKV
  • EYAFSLFQ
  • YPVILSLE
  • LTKRAEVQELFE
  • RVYPSGLRTDSSN
  • YHGHTLT
  • SSVEGYIR
  • ILCPALS

Post-translational modifications for PLCD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PLCD4 Gene

Suggested Antigen Peptide Sequences for PLCD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRC7

UniProtKB/Swiss-Prot:

PLCD4_HUMAN :
  • The PDZ-binding motif mediates the interaction with GRIP1.
Domain:
  • The PDZ-binding motif mediates the interaction with GRIP1.
  • The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.
  • The PH domain is not a critical determinant of the membrane localization.
genes like me logo Genes that share domains with PLCD4: view

Function for PLCD4 Gene

Molecular function for PLCD4 Gene

GENATLAS Biochemistry:
phospholipase C,delta 4,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot Function:
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Enzyme Numbers (IUBMB) for PLCD4 Gene

Gene Ontology (GO) - Molecular Function for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS --
GO:0004629 phospholipase C activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCD4: view
genes like me logo Genes that share phenotypes with PLCD4: view

Animal Models for PLCD4 Gene

MGI Knock Outs for PLCD4:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCD4

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLCD4 Gene

Localization for PLCD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCD4 Gene

Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCD4 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PLCD4: view

Pathways & Interactions for PLCD4 Gene

genes like me logo Genes that share pathways with PLCD4: view

Gene Ontology (GO) - Biological Process for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007340 acrosome reaction IEA --
GO:0016042 lipid catabolic process IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PLCD4: view

No data available for SIGNOR curated interactions for PLCD4 Gene

Drugs & Compounds for PLCD4 Gene

(2) Drugs for PLCD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
calcium Nutra 0

(387) Additional Compounds for PLCD4 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for PLCD4 Gene

Compound Action Cas Number
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCD4: view

Transcripts for PLCD4 Gene

Unigene Clusters for PLCD4 Gene

Phospholipase C, delta 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: