Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLCD4 Gene

Aliases for PLCD4 Gene

  • Phospholipase C Delta 4 2 3 5
  • EC 3.1.4.11 4 61
  • Phosphoinositide Phospholipase C-Delta-4 4
  • Phospholipase C, Delta 4 2
  • Phospholipase C-Delta-4 4
  • PLC-Delta-4 4
  • HPLCD4 4

External Ids for PLCD4 Gene

Previous GeneCards Identifiers for PLCD4 Gene

  • GC02U990230
  • GC02P218193
  • GC02P219436
  • GC02P219675
  • GC02P219298
  • GC02P219180
  • GC02P211325
  • GC02P219473

Summaries for PLCD4 Gene

Entrez Gene Summary for PLCD4 Gene

  • This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]

GeneCards Summary for PLCD4 Gene

PLCD4 (Phospholipase C Delta 4) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and G-Beta Gamma Signaling. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCD3.

UniProtKB/Swiss-Prot for PLCD4 Gene

  • Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Tocris Summary for PLCD4 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCD4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCD4 Gene

Genomics for PLCD4 Gene

Regulatory Elements for PLCD4 Gene

Enhancers for PLCD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F218581 0.4 ENCODE 21.9 -25.4 -25443 1.8 KLF1 RFX1 JUN JUNB RAD21 OSR2 JUND RFX3 IKZF1 FOS PLCD4 CNOT9 STK36 RNF25 GC02M218590 RNU6-136P
GH02F218443 0.7 ENCODE 21.5 -161.9 -161930 4.1 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS CNOT9 PLCD4 FAM134A USP37 VIL1 RN7SKP38
GH02F218566 1.4 FANTOM5 ENCODE 21.4 -38.4 -38448 4.7 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CNOT9 PLCD4 BCS1L STK36 USP37 SLC23A3 NHEJ1 AAMP ENSG00000269068 ZNF142
GH02F218743 1 Ensembl ENCODE 19.2 +137.3 137319 3.6 PKNOX1 ARID4B DMAP1 JUNB NCOA1 MIER2 PPARG KAT8 CREB3 MEF2D CYP27A1 PLCD4 TTLL4 PRKAG3 RNF25 STK36 GC02P218766
GH02F218730 1.6 FANTOM5 Ensembl ENCODE 18.4 +124.9 124937 4.6 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 SLC11A1 CYP27A1 PLCD4 USP37 NHEJ1 RNF25 BCS1L ZNF142 AAMP PNKD
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PLCD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCD4 Gene

Chromosome:
2
Start:
218,607,765 bp from pter
End:
218,637,186 bp from pter
Size:
29,422 bases
Orientation:
Plus strand

Genomic View for PLCD4 Gene

Genes around PLCD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCD4 Gene

Proteins for PLCD4 Gene

  • Protein details for PLCD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRC7-PLCD4_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
    Protein Accession:
    Q9BRC7
    Secondary Accessions:
    • Q53FS8

    Protein attributes for PLCD4 Gene

    Size:
    762 amino acids
    Molecular mass:
    87585 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with GRIP1.

    Alternative splice isoforms for PLCD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCD4 Gene

Post-translational modifications for PLCD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PLCD4 Gene

Suggested Antigen Peptide Sequences for PLCD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRC7

UniProtKB/Swiss-Prot:

PLCD4_HUMAN :
  • The PDZ-binding motif mediates the interaction with GRIP1.
Domain:
  • The PDZ-binding motif mediates the interaction with GRIP1.
  • The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.
  • The PH domain is not a critical determinant of the membrane localization.
  • Contains 1 C2 domain.
  • Contains 3 EF-hand domains.
  • Contains 1 PH domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCD4: view

Function for PLCD4 Gene

Molecular function for PLCD4 Gene

GENATLAS Biochemistry:
phospholipase C,delta 4,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot Function:
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Enzyme Numbers (IUBMB) for PLCD4 Gene

Gene Ontology (GO) - Molecular Function for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004629 phospholipase C activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCD4: view
genes like me logo Genes that share phenotypes with PLCD4: view

Animal Models for PLCD4 Gene

MGI Knock Outs for PLCD4:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCD4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLCD4 Gene

Localization for PLCD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCD4 Gene

Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCD4 Gene COMPARTMENTS Subcellular localization image for PLCD4 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with PLCD4: view

Pathways & Interactions for PLCD4 Gene

genes like me logo Genes that share pathways with PLCD4: view

Gene Ontology (GO) - Biological Process for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007340 acrosome reaction IEA --
GO:0016042 lipid catabolic process IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PLCD4: view

No data available for SIGNOR curated interactions for PLCD4 Gene

Drugs & Compounds for PLCD4 Gene

(2) Drugs for PLCD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
calcium Nutra 0

(387) Additional Compounds for PLCD4 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for PLCD4 Gene

Compound Action Cas Number
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCD4: view

Transcripts for PLCD4 Gene

Unigene Clusters for PLCD4 Gene

Phospholipase C, delta 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6:
SP7: -
SP8:
SP9: -
SP10:

ExUns: 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PLCD4 Gene

GeneLoc Exon Structure for
PLCD4
ECgene alternative splicing isoforms for
PLCD4

Expression for PLCD4 Gene

mRNA expression in normal human tissues for PLCD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCD4 Gene

This gene is overexpressed in Muscle - Skeletal (x13.1).

Protein differential expression in normal tissues from HIPED for PLCD4 Gene

This gene is overexpressed in Retina (39.6) and Tonsil (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLCD4 Gene



NURSA nuclear receptor signaling pathways regulating expression of PLCD4 Gene:

PLCD4

SOURCE GeneReport for Unigene cluster for PLCD4 Gene:

Hs.632528

mRNA Expression by UniProt/SwissProt for PLCD4 Gene:

Q9BRC7-PLCD4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells.
genes like me logo Genes that share expression patterns with PLCD4: view

Primer Products

No data available for Protein tissue co-expression partners for PLCD4 Gene

Orthologs for PLCD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCD4 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia PLCD4 34 35
  • 86.47 (n)
cow
(Bos Taurus)
Mammalia PLCD4 34 35
  • 85.72 (n)
rat
(Rattus norvegicus)
Mammalia Plcd4 34
  • 79.59 (n)
mouse
(Mus musculus)
Mammalia Plcd4 34 16 35
  • 79.15 (n)
oppossum
(Monodelphis domestica)
Mammalia PLCD4 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC424214 34
  • 67.12 (n)
PLCD4 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCD4 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plcd4 34
  • 63.64 (n)
zebrafish
(Danio rerio)
Actinopterygii plcd4a 34 35
  • 61.99 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D00638g 34
  • 46.26 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR024W 34
  • 45.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLC1 34
  • 43.92 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PLC4 34
  • 45.12 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01266 34
  • 46.89 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes plc1 34
  • 44.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
Species where no ortholog for PLCD4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLCD4 Gene

ENSEMBL:
Gene Tree for PLCD4 (if available)
TreeFam:
Gene Tree for PLCD4 (if available)

Paralogs for PLCD4 Gene

Paralogs for PLCD4 Gene

genes like me logo Genes that share paralogs with PLCD4: view

Variants for PLCD4 Gene

Sequence variations from dbSNP and Humsavar for PLCD4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10173864 -- 218,609,277(+) TTCTT(G/T)CTTGC intron-variant, upstream-variant-2KB
rs1055816 -- 218,636,605(+) TTGGT(A/G)TGCTG intron-variant, utr-variant-3-prime
rs10616178 -- 218,626,273(+) AAAAA(-/AA)GGAAA intron-variant
rs111274966 -- 218,608,234(+) TCTAG(C/T)TTATC intron-variant, upstream-variant-2KB
rs111325451 -- 218,627,703(+) AGATG(-/GGGTTTCACC/GGTTTCACC)GGGTT