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Aliases for PLCD4 Gene

Aliases for PLCD4 Gene

  • Phospholipase C Delta 4 2 3 5
  • EC 3.1.4.11 4 61
  • Phosphoinositide Phospholipase C-Delta-4 4
  • Phospholipase C, Delta 4 2
  • Phospholipase C-Delta-4 4
  • PLC-Delta-4 4
  • HPLCD4 4

External Ids for PLCD4 Gene

Previous GeneCards Identifiers for PLCD4 Gene

  • GC02U990230
  • GC02P218193
  • GC02P219436
  • GC02P219675
  • GC02P219298
  • GC02P219180
  • GC02P211325
  • GC02P219473

Summaries for PLCD4 Gene

Entrez Gene Summary for PLCD4 Gene

  • This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]

GeneCards Summary for PLCD4 Gene

PLCD4 (Phospholipase C Delta 4) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and G-Beta Gamma Signaling. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCD3.

UniProtKB/Swiss-Prot for PLCD4 Gene

  • Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Tocris Summary for PLCD4 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCD4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCD4 Gene

Genomics for PLCD4 Gene

Regulatory Elements for PLCD4 Gene

Enhancers for PLCD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F218566 1.6 FANTOM5 ENCODE 21.4 -38.4 -38448 4.7 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CNOT9 PLCD4 BCS1L STK36 USP37 SLC23A3 NHEJ1 AAMP ENSG00000269068 ZNF142
GH02F218730 1.8 FANTOM5 Ensembl ENCODE 18.4 +124.9 124937 4.6 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 SLC11A1 CYP27A1 PLCD4 USP37 NHEJ1 RNF25 ZNF142 BCS1L AAMP PNKD
GH02F218781 1.4 FANTOM5 ENCODE 17.2 +175.7 175657 5.6 ATF1 PKNOX1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 FOS ZNF263 CYP27A1 PLCD4 TTLL4 PRKAG3 PNKD SLC11A1 RNF25 TMBIM1 ENSG00000272555
GH02F218443 1.1 ENCODE 21.5 -161.9 -161930 4.1 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS CNOT9 PLCD4 FAM134A USP37 VIL1 RN7SKP38
GH02F218743 1.2 Ensembl ENCODE 19.2 +137.3 137319 3.6 PKNOX1 ARID4B DMAP1 JUNB NCOA1 MIER2 PPARG KAT8 CREB3 MEF2D CYP27A1 PLCD4 TTLL4 PRKAG3 STK36 RNF25 GC02P218766
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLCD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCD4 Gene

Chromosome:
2
Start:
218,607,765 bp from pter
End:
218,637,186 bp from pter
Size:
29,422 bases
Orientation:
Plus strand

Genomic View for PLCD4 Gene

Genes around PLCD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCD4 Gene

Proteins for PLCD4 Gene

  • Protein details for PLCD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRC7-PLCD4_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
    Protein Accession:
    Q9BRC7
    Secondary Accessions:
    • Q53FS8

    Protein attributes for PLCD4 Gene

    Size:
    762 amino acids
    Molecular mass:
    87585 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with GRIP1.

    Alternative splice isoforms for PLCD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCD4 Gene

Selected DME Specific Peptides for PLCD4 Gene

Q9BRC7:
  • FYEISSFSE
  • SSFSETKA
  • PLNHYFI
  • GYRHIHLLS
  • DTARQET
  • NQDGKMS
  • GYVLKPDFLRD
  • AKPSFSISDV
  • DGFLSYLCS
  • QERLDQWLSDWFQRGDKNQDG
  • HLTEILGEQLLSTTLDG
  • CGYVLKP
  • CLPIYQDMTQPL
  • SIVDPLV
  • TDQDLLLMQEG
  • DYDWKSRNDF
  • GCQMVAMNMQTAG
  • SGTLEGEEFV
  • LMNVEMD
  • MRKVRSKSWKKLR
  • DGMTVWH
  • SSHNTYL
  • EGYIRALKRGCRCVEVD
  • SGKLRHVLSMDGFL
  • VDPLVKV
  • EYAFSLFQ
  • YPVILSLE
  • LTKRAEVQELFE
  • RVYPSGLRTDSSN
  • YHGHTLT
  • SSVEGYIR
  • ILCPALS

Post-translational modifications for PLCD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PLCD4 Gene

Suggested Antigen Peptide Sequences for PLCD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRC7

UniProtKB/Swiss-Prot:

PLCD4_HUMAN :
  • The PDZ-binding motif mediates the interaction with GRIP1.
Domain:
  • The PDZ-binding motif mediates the interaction with GRIP1.
  • The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.
  • The PH domain is not a critical determinant of the membrane localization.
  • Contains 1 C2 domain.
  • Contains 3 EF-hand domains.
  • Contains 1 PH domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCD4: view

Function for PLCD4 Gene

Molecular function for PLCD4 Gene

GENATLAS Biochemistry:
phospholipase C,delta 4,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot Function:
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

Enzyme Numbers (IUBMB) for PLCD4 Gene

Gene Ontology (GO) - Molecular Function for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004629 phospholipase C activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCD4: view
genes like me logo Genes that share phenotypes with PLCD4: view

Animal Models for PLCD4 Gene

MGI Knock Outs for PLCD4:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCD4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLCD4 Gene

Localization for PLCD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCD4 Gene

Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCD4 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with PLCD4: view

Pathways & Interactions for PLCD4 Gene

genes like me logo Genes that share pathways with PLCD4: view

Gene Ontology (GO) - Biological Process for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007340 acrosome reaction IEA --
GO:0016042 lipid catabolic process IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PLCD4: view

No data available for SIGNOR curated interactions for PLCD4 Gene

Drugs & Compounds for PLCD4 Gene

(2) Drugs for PLCD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
calcium Nutra 0

(387) Additional Compounds for PLCD4 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for PLCD4 Gene

Compound Action Cas Number
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCD4: view

Transcripts for PLCD4 Gene

Unigene Clusters for PLCD4 Gene

Phospholipase C, delta 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6:
SP7: -
SP8:
SP9: -
SP10:

ExUns: 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PLCD4 Gene

GeneLoc Exon Structure for
PLCD4
ECgene alternative splicing isoforms for
PLCD4

Expression for PLCD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLCD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery