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Aliases for PLCD3 Gene

Aliases for PLCD3 Gene

  • Phospholipase C Delta 3 2 3 5
  • Phosphoinositide Phospholipase C-Delta-3 3 4
  • PLC-Delta-3 3 4
  • EC 3.1.4.11 4 56
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3 3
  • 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Delta-3 3
  • Phospholipase C, Delta 3 2
  • Phospholipase C-Delta-3 4
  • PLC Delta3 3
  • KIAA1964 4

External Ids for PLCD3 Gene

Previous GeneCards Identifiers for PLCD3 Gene

  • GC17U990190
  • GC17P045239
  • GC17M043197
  • GC17M043664
  • GC17M040544
  • GC17M038952
  • GC17M043186

Summaries for PLCD3 Gene

Entrez Gene Summary for PLCD3 Gene

  • This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLCD3 Gene

PLCD3 (Phospholipase C Delta 3) is a Protein Coding gene. Among its related pathways are NFAT and Cardiac Hypertrophy and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCD1.

UniProtKB/Swiss-Prot for PLCD3 Gene

  • Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.

Tocris Summary for PLCD3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCD3 Gene

Additional gene information for PLCD3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCD3 Gene

Genomics for PLCD3 Gene

GeneHancer (GH) Regulatory Elements for PLCD3 Gene

Promoters and enhancers for PLCD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I045126 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 559.5 +3.3 3252 7 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ACBD4 PLCD3 ENSG00000262372 ASB16-AS1 UBTF TMUB2 LINC02210 ENSG00000224505 DCAKD GPATCH8
GH17I045089 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.2 +41.1 41148 4.6 FOXA2 ZSCAN4 ARID4B SIN3A RAD21 RARA YY1 ZNF121 FOS ZNF362 DCAKD PLCD3 GFAP NMT1 ACBD4 HEXIM1 HIGD1B ADAM11 MIR6784 ENSG00000200888
GH17I045157 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.3 -27.1 -27094 5.4 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ENSG00000224505 HEXIM2 ENSG00000262372 UBTF TMUB2 ASB16-AS1 MAP3K14-AS1 EFTUD2 ACBD4 PLCD3
GH17I045059 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.3 +71.6 71608 4.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DCAKD PIR53442 NMT1 ENSG00000262372 ASB16-AS1 TMUB2 UBTF C17orf53 MAP3K14-AS1 LSM12
GH17I045196 Enhancer 1.3 Ensembl ENCODE 12.7 -64.4 -64390 1.9 HDGF MLX ARNT ARID4B SIN3A ZNF2 ZNF207 ZNF143 DEK SP3 ENSG00000262372 UBTF HEXIM1 PLCD3 ACBD4 ENSG00000224505 DCAKD ENSG00000233483 ENSG00000267405 GC17P045196
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLCD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLCD3 gene promoter:

Genomic Locations for PLCD3 Gene

Genomic Locations for PLCD3 Gene
chr17:45,108,967-45,133,354
(GRCh38/hg38)
Size:
24,388 bases
Orientation:
Minus strand
chr17:43,186,335-43,210,721
(GRCh37/hg19)

Genomic View for PLCD3 Gene

Genes around PLCD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCD3 Gene

Proteins for PLCD3 Gene

  • Protein details for PLCD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3E9-PLCD3_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
    Protein Accession:
    Q8N3E9
    Secondary Accessions:
    • Q8TEC1
    • Q8TF37
    • Q96FL6

    Protein attributes for PLCD3 Gene

    Size:
    789 amino acids
    Molecular mass:
    89258 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLCD3 Gene

Selected DME Specific Peptides for PLCD3 Gene

Q8N3E9:
  • GCRCVELD
  • GYRHIHLLS
  • CGYVLKP
  • SIVDPLV
  • SSHNTYL
  • VALNFQT
  • YPVILSLE
  • LVRFVVEDYD
  • YHGHTLT

Post-translational modifications for PLCD3 Gene

No Post-translational modifications

Other Protein References for PLCD3 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for PLCD3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PLCD3

Domains & Families for PLCD3 Gene

Gene Families for PLCD3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PLCD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N3E9

UniProtKB/Swiss-Prot:

PLCD3_HUMAN :
  • The C2 domain is a Ca(2+)-dependent membrane-targeting module.
Domain:
  • The C2 domain is a Ca(2+)-dependent membrane-targeting module.
  • The PH domain mediates interaction with the surface membrane by binding to PIP2.
genes like me logo Genes that share domains with PLCD3: view

Function for PLCD3 Gene

Molecular function for PLCD3 Gene

GENATLAS Biochemistry:
phospholipase C,delta 3,involved in signal transduction
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=105.3 uM for PIP2 {ECO:0000269 PubMed:10336610}; Vmax=28.5 umol/min/mg enzyme {ECO:0000269 PubMed:10336610};
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer).
UniProtKB/Swiss-Prot Function:
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
UniProtKB/Swiss-Prot Induction:
Down-regulated by Ca(2+) and cAMP.

Enzyme Numbers (IUBMB) for PLCD3 Gene

Phenotypes From GWAS Catalog for PLCD3 Gene

Gene Ontology (GO) - Molecular Function for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS,IEA --
GO:0004871 signal transducer activity IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLCD3: view
genes like me logo Genes that share phenotypes with PLCD3: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCD3 Gene

Localization for PLCD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCD3 Gene

Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCD3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLCD3: view

Pathways & Interactions for PLCD3 Gene

genes like me logo Genes that share pathways with PLCD3: view

Interacting Proteins for PLCD3 Gene

Gene Ontology (GO) - Biological Process for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0016042 lipid catabolic process IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PLCD3: view

No data available for SIGNOR curated interactions for PLCD3 Gene

Drugs & Compounds for PLCD3 Gene

(5) Drugs for PLCD3 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Diltiazem Approved, Investigational Pharma Channel blocker 78
Water Approved Pharma 0
cyclic amp Experimental Pharma 0

(566) Additional Compounds for PLCD3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-sn-glycerol
  • DAG(14:0/15:0)
  • DAG(29:0)
  • DG(14:0/15:0)
  • DG(29:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonoyl-sn-glycerol
  • DAG(16:1/20:4)
  • DAG(16:1n7/20:4n6)
  • DAG(16:1w7/20:4w6)
  • DAG(36:5)
Diglycerides Group C
  • 1-Pentadecanoyl-3-behenoyl-sn-glycerol
  • 1-Pentadecanoyl-3-docosanoyl-sn-glycerol
  • DAG(15:0/0:0/22:0)
  • DAG(37:0)
  • DG(37:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PLCD3 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCD3: view

Transcripts for PLCD3 Gene

Unigene Clusters for PLCD3 Gene

Phospholipase C, delta 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: -
SP6: -
SP7:

Relevant External Links for PLCD3 Gene

GeneLoc Exon Structure for
PLCD3
ECgene alternative splicing isoforms for
PLCD3

Expression for PLCD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLCD3 Gene

Protein differential expression in normal tissues from HIPED for PLCD3 Gene

This gene is overexpressed in Spinal cord (24.6), Amniocyte (16.5), and Brain (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLCD3 Gene



NURSA nuclear receptor signaling pathways regulating expression of PLCD3 Gene:

PLCD3

SOURCE GeneReport for Unigene cluster for PLCD3 Gene:

Hs.380094

mRNA Expression by UniProt/SwissProt for PLCD3 Gene:

Q8N3E9-PLCD3_HUMAN
Tissue specificity: Present in corneal epithelial cells (at protein level).

Evidence on tissue expression from TISSUES for PLCD3 Gene

  • Nervous system(4.6)
  • Intestine(4.3)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with PLCD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCD3 Gene

Orthologs for PLCD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCD3 33
  • 95.85 (n)
cow
(Bos Taurus)
Mammalia PLCD3 33 34
  • 87.94 (n)
dog
(Canis familiaris)
Mammalia PLCD3 33 34
  • 86.74 (n)
mouse
(Mus musculus)
Mammalia Plcd3 34 16 33
  • 85.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcd3 33
  • 85.14 (n)
oppossum
(Monodelphis domestica)
Mammalia PLCD3 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLCD3 34 33
  • 71.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCD3 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plcd3 33
  • 64.07 (n)
zebrafish
(Danio rerio)
Actinopterygii plcd3a 33 34
  • 60.19 (n)
plcd3b 34
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea plc-4 33
  • 46.8 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PLC1 33
  • 44.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToMany
Species where no ortholog for PLCD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCD3 Gene

ENSEMBL:
Gene Tree for PLCD3 (if available)
TreeFam:
Gene Tree for PLCD3 (if available)

Paralogs for PLCD3 Gene

Paralogs for PLCD3 Gene

genes like me logo Genes that share paralogs with PLCD3: view

Variants for PLCD3 Gene

Sequence variations from dbSNP and Humsavar for PLCD3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000037052 -- 45,132,545(-) G/C upstream_transcript_variant
rs1000499129 -- 45,130,704(-) C/T intron_variant
rs1000555930 -- 45,126,303(-) C/T intron_variant
rs1000576053 -- 45,111,717(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000920141 -- 45,126,230(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLCD3 Gene

Variant ID Type Subtype PubMed ID
dgv926e212 CNV loss 25503493
nsv1146669 OTHER inversion 26484159
nsv522514 CNV loss 19592680
nsv527788 CNV loss 19592680
nsv953903 CNV deletion 24416366

Variation tolerance for PLCD3 Gene

Gene Damage Index Score: 1.92; 35.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLCD3 Gene

Human Gene Mutation Database (HGMD)
PLCD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLCD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCD3 Gene

Disorders for PLCD3 Gene

Additional Disease Information for PLCD3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLCD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCD3 Gene

Publications for PLCD3 Gene

  1. Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization. (PMID: 10702670) Kim H … Park SH (Cytogenetics and cell genetics 1999) 2 3 4 22 58
  2. Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium. (PMID: 9799116) Pawelczyk T … Matecki A (European journal of biochemistry 1998) 3 4 22 58
  3. Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties. (PMID: 9056492) Ghosh S … Lowenstein JM (Protein expression and purification 1997) 2 3 4 58
  4. Expression, purification and kinetic properties of human recombinant phospholipase C delta 3. (PMID: 9360711) Pawełczyk T … Matecki A (Acta biochimica Polonica 1997) 3 4 22 58
  5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58

Products for PLCD3 Gene