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Aliases for PLCD3 Gene

Aliases for PLCD3 Gene

  • Phospholipase C Delta 3 2 3 5
  • Phosphoinositide Phospholipase C-Delta-3 3 4
  • Phospholipase C, Delta 3 2 3
  • PLC-Delta-3 3 4
  • EC 3.1.4.11 4 63
  • 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Delta-3 3
  • Phospholipase C-Delta-3 4
  • PLC Delta3 3
  • KIAA1964 4

External Ids for PLCD3 Gene

Previous GeneCards Identifiers for PLCD3 Gene

  • GC17U990190
  • GC17P045239
  • GC17M043197
  • GC17M043664
  • GC17M040544
  • GC17M038952
  • GC17M043186

Summaries for PLCD3 Gene

Entrez Gene Summary for PLCD3 Gene

  • This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLCD3 Gene

PLCD3 (Phospholipase C Delta 3) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Thyroid hormone signaling pathway. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCB3.

UniProtKB/Swiss-Prot for PLCD3 Gene

  • Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.

Tocris Summary for PLCD3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCD3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCD3 Gene

Genomics for PLCD3 Gene

Regulatory Elements for PLCD3 Gene

Enhancers for PLCD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLCD3 on UCSC Golden Path with GeneCards custom track

Promoters for PLCD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLCD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCD3 Gene

Chromosome:
17
Start:
45,108,967 bp from pter
End:
45,133,354 bp from pter
Size:
24,388 bases
Orientation:
Minus strand

Genomic View for PLCD3 Gene

Genes around PLCD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCD3 Gene

Proteins for PLCD3 Gene

  • Protein details for PLCD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3E9-PLCD3_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
    Protein Accession:
    Q8N3E9
    Secondary Accessions:
    • Q8TEC1
    • Q8TF37
    • Q96FL6

    Protein attributes for PLCD3 Gene

    Size:
    789 amino acids
    Molecular mass:
    89258 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLCD3 Gene

Proteomics data for PLCD3 Gene at MOPED

Selected DME Specific Peptides for PLCD3 Gene

Post-translational modifications for PLCD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCD3 Gene

Antibody Products

Domains & Families for PLCD3 Gene

Gene Families for PLCD3 Gene

Suggested Antigen Peptide Sequences for PLCD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N3E9

UniProtKB/Swiss-Prot:

PLCD3_HUMAN :
  • The C2 domain is a Ca(2+)-dependent membrane-targeting module.
Domain:
  • The C2 domain is a Ca(2+)-dependent membrane-targeting module.
  • The PH domain mediates interaction with the surface membrane by binding to PIP2.
  • Contains 1 C2 domain.
  • Contains 3 EF-hand domains.
  • Contains 1 PH domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCD3: view

Function for PLCD3 Gene

Molecular function for PLCD3 Gene

GENATLAS Biochemistry:
phospholipase C,delta 3,involved in signal transduction
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=105.3 uM for PIP2 {ECO:0000269 PubMed:10336610}; Vmax=28.5 umol/min/mg enzyme {ECO:0000269 PubMed:10336610};
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer).
UniProtKB/Swiss-Prot Function:
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
UniProtKB/Swiss-Prot Induction:
Down-regulated by Ca(2+) and cAMP.

Enzyme Numbers (IUBMB) for PLCD3 Gene

Gene Ontology (GO) - Molecular Function for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA,TAS --
genes like me logo Genes that share ontologies with PLCD3: view
genes like me logo Genes that share phenotypes with PLCD3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCD3

miRNA for PLCD3 Gene

miRTarBase miRNAs that target PLCD3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCD3 Gene

Localization for PLCD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCD3 Gene

Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCD3 Gene COMPARTMENTS Subcellular localization image for PLCD3 gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 3

No data available for Gene Ontology (GO) - Cellular Components for PLCD3 Gene

Pathways & Interactions for PLCD3 Gene

genes like me logo Genes that share pathways with PLCD3: view

Interacting Proteins for PLCD3 Gene

Selected Interacting proteins: Q8N3E9-PLCD3_HUMAN for PLCD3 Gene via MINT I2D

Symbol External ID(s) Details
SKIL

Gene Ontology (GO) - Biological Process for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0042127 regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with PLCD3: view

No data available for SIGNOR curated interactions for PLCD3 Gene

Drugs & Compounds for PLCD3 Gene

(5) Drugs for PLCD3 Gene - From: PharmGKB, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diltiazem Approved Pharma Channel blocker 72
cyclic amp Experimental Pharma 0
calcium Nutra 0
D609 Pharma PC-PLC inhibitor, Selective PC-PLC inhibitor 0

(569) Additional Compounds for PLCD3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PLCD3 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
RHC 80267 Diacylglycerol lipase inhibitor 83654-05-1
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCD3: view

Transcripts for PLCD3 Gene

Unigene Clusters for PLCD3 Gene

Phospholipase C, delta 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: -
SP6: -
SP7:

Relevant External Links for PLCD3 Gene

GeneLoc Exon Structure for
PLCD3
ECgene alternative splicing isoforms for
PLCD3

Expression for PLCD3 Gene

mRNA expression in normal human tissues for PLCD3 Gene

Protein differential expression in normal tissues from HIPED for PLCD3 Gene

This gene is overexpressed in Spinal cord (24.6), Amniocyte (16.5), and Brain (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PLCD3 Gene



SOURCE GeneReport for Unigene cluster for PLCD3 Gene Hs.380094

mRNA Expression by UniProt/SwissProt for PLCD3 Gene

Q8N3E9-PLCD3_HUMAN
Tissue specificity: Present in corneal epithelial cells (at protein level).
genes like me logo Genes that share expression patterns with PLCD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for PLCD3 Gene

Orthologs for PLCD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLCD3 35
  • 87.94 (n)
  • 88.49 (a)
PLCD3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCD3 35
  • 86.74 (n)
  • 87.83 (a)
PLCD3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcd3 35
  • 85.77 (n)
  • 88.41 (a)
Plcd3 16
Plcd3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLCD3 35
  • 95.85 (n)
  • 95.35 (a)
rat
(Rattus norvegicus)
Mammalia Plcd3 35
  • 85.14 (n)
  • 87.9 (a)
oppossum
(Monodelphis domestica)
Mammalia PLCD3 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLCD3 35
  • 71.54 (n)
  • 66.21 (a)
PLCD3 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCD3 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plcd3 35
  • 64.07 (n)
  • 64.5 (a)
zebrafish
(Danio rerio)
Actinopterygii plcd3a 35
  • 60.19 (n)
  • 53.94 (a)
plcd3a 36
  • 50 (a)
OneToMany
plcd3b 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea plc-4 35
  • 46.8 (n)
  • 40.72 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PLC1 35
  • 44.7 (n)
  • 35.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for PLCD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCD3 Gene

ENSEMBL:
Gene Tree for PLCD3 (if available)
TreeFam:
Gene Tree for PLCD3 (if available)

Paralogs for PLCD3 Gene

Paralogs for PLCD3 Gene

genes like me logo Genes that share paralogs with PLCD3: view

Variants for PLCD3 Gene

Sequence variations from dbSNP and Humsavar for PLCD3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs734921 - 45,113,478(+) TACTC(A/G)GGGTC reference, synonymous-codon
rs739454 -- 45,117,838(-) GGGGT(A/G)GCATA intron-variant
rs1052169 -- 45,111,681(-) CTATC(G/T)AGTTT utr-variant-3-prime
rs2129731 -- 45,120,243(-) ATCAG(C/T)TCCCC intron-variant
rs2129732 -- 45,120,226(-) CTCCA(C/T)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLCD3 Gene

Variant ID Type Subtype PubMed ID
nsv527788 CNV Loss 19592680
dgv3178n71 CNV Loss 21882294
nsv908297 CNV Loss 21882294
dgv3179n71 CNV Loss 21882294
nsv908300 CNV Loss 21882294
nsv522514 CNV Loss 19592680

Variation tolerance for PLCD3 Gene

Gene Damage Index Score: 1.92; 35.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLCD3 Gene

Disorders for PLCD3 Gene

Relevant External Links for PLCD3

Genetic Association Database (GAD)
PLCD3
Human Genome Epidemiology (HuGE) Navigator
PLCD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLCD3

No disorders were found for PLCD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCD3 Gene

Publications for PLCD3 Gene

  1. Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization. (PMID: 10702670) Kim H. … Park S.H. (Cytogenet. Cell Genet. 1999) 2 3 4 23 67
  2. Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium. (PMID: 9799116) Pawelczyk T. … Matecki A. (Eur. J. Biochem. 1998) 3 23
  3. Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties. (PMID: 9056492) Ghosh S. … Lowenstein J.M. (Protein Expr. Purif. 1997) 2 3
  4. Expression, purification and kinetic properties of human recombinant phospholipase C delta 3. (PMID: 9360711) Pawelczyk T. … Matecki A. (Acta Biochim. Pol. 1997) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PLCD3 Gene

Sources for PLCD3 Gene

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