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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLCD3 Gene

protein-coding   GIFtS: 66
GCID: GC17M043197

Phospholipase C, Delta 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase C, Delta 31 2     1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-32
Phosphoinositide Phospholipase C-Delta-32 3     1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Delta-32
Phospholipase C-Delta-32 3     PLC Delta32
PLC-delta-32 3     KIAA19643
EC 3.1.4.113 8     

External Ids:    HGNC: 90611   Entrez Gene: 1130262   Ensembl: ENSG000001617147   OMIM: 6087955   UniProtKB: Q8N3E93   

Export aliases for PLCD3 gene to outside databases

Previous GC identifers: GC17U990190 GC17P045239 GC17M043664 GC17M040544 GC17M038952


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLCD3 Gene:
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol
4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3).
Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein
kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and
requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PLCD3 Gene: 
PLCD3 (phospholipase C, delta 3) is a protein-coding gene. Diseases associated with PLCD3 include neurologic diseases, and huntington's disease, and among its related super-pathways are D-myo-inositol (1,4,5)-trisphosphate biosynthesis and Phosphatidylinositol signaling system. GO annotations related to this gene include signal transducer activity and calcium ion binding. An important paralog of this gene is PLCD4.

UniProtKB/Swiss-Prot: PLCD3_HUMAN, Q8N3E9
Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules
diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C
(PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development.
May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow

summary for PLCD3 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLCD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLCD3 gene promoter:
         E2F-4   E2F-3a   E2F-5   STAT5A   E2F-2   Nkx2-5   C/EBPalpha   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLCD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

PLCD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCD3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M043197:  view genomic region     (about GC identifiers)

Start:
43,186,335 bp from pter      End:
43,210,721 bp from pter
Size:
24,387 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLCD3_HUMAN, Q8N3E9 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3  
Size: 789 amino acids; 89258 Da
Cofactor: Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain (Probable)
Subcellular location: Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the
cleavage furrow during cytokinesis
Secondary accessions: Q8TEC1 Q8TF37 Q96FL6

Explore the universe of human proteins at neXtProt for PLCD3: NX_Q8N3E9

Explore proteomics data for PLCD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N3E9

  • 4/9 DME Specific Peptides for PLCD3 (Q8N3E9) (see all 9)
     SIVDPLV  VALNFQT  YHGHTLT  CGYVLKP 

    PLCD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLCD3 Protein Expression
    REFSEQ proteins: NP_588614.1  
    ENSEMBL proteins: 
     ENSP00000443079   ENSP00000466517   ENSP00000465643   ENSP00000467800   ENSP00000440378  
     ENSP00000313731  
    Reactome Protein details: Q8N3E9
    Human Recombinant Protein Products for PLCD3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals PLCD3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0032154cleavage furrow IEA--

    PLCD3 for ontologies           About GeneDecksing



    PLCD3 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: PLCδ3 
    Phosphoinositide-specific phospholipase C

    5/12 InterPro protein domains (see all 12):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-like_dom
     IPR001192 Pinositol_PLipase_C
     IPR001849 Pleckstrin_homology
     IPR018029 C2_membr_targeting

    Graphical View of Domain Structure for InterPro Entry Q8N3E9

    ProtoNet protein and cluster: Q8N3E9

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PLCD3_HUMAN, Q8N3E9
    Domain: The C2 domain is a Ca(2+)-dependent membrane-targeting module
    Domain: The PH domain mediates interaction with the surface membrane by binding to PIP2
    Similarity: Contains 1 C2 domain
    Similarity: Contains 3 EF-hand domains
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain


    PLCD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCD3_HUMAN, Q8N3E9
    Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules
    diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C
    (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development.
    May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
    + diacylglycerol
    Enzyme regulation: Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn),
    phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer)
    Biophysicochemical properties: Kinetic parameters: KM=105.3 uM for PIP2; Vmax=28.5 umol/min/mg enzyme;
    Induction: Down-regulated by Ca(2+) and cAMP

         Genatlas biochemistry entry for PLCD3:
    phospholipase C,delta 3,involved in signal transduction

         Enzyme Number (IUBMB): EC 3.1.4.111 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    PLCD3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Plcd3 (no phenotypes)

    PLCD3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLCD3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLCD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLCD3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLCD3 

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCD3:
    hsa-miR-221* hsa-miR-485-5p hsa-miR-185* hsa-miR-654-5p hsa-miR-541
    SwitchGear 3'UTR luciferase reporter plasmidPLCD3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLCD3 About   (see all 29)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Anandamide biosynthesis and metabolism
    D-myo-inositol-5-phosphate metabolism0.50
    Anandamide biosynthesis and metabolism0.34
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.50
    phospholipases0.34
    2Inositol phosphate metabolism
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Cellular Effects of Sildenafil0.46
    Melatonin Signaling0.72
    Sperm Motility0.37
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PLCD3
        Anandamide biosynthesis and metabolism

    5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLCD3 (see all 38)
        Antioxidant Action of Vitamin-C
    Intracellular Calcium Signaling
    Aldosterone Signaling in Epithelial Cells
    UVA-Induced MAPK Signaling
    PACAP Signaling

    1 GeneGo (Thomson Reuters) Pathway for PLCD3
        Anandamide biosynthesis and metabolism

    4 BioSystems Pathways for PLCD3
        D-myo-inositol-5-phosphate metabolism
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis
    phospholipases
    superpathway of inositol phosphate compounds

    3        Reactome Pathways for PLCD3
        Metabolism
    Inositol phosphate metabolism
    Synthesis of IP3 and IP4 in the cytosol

    1 PharmGKB Pathway for PLCD3
        Proton Pump Inhibitor Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for PLCD3):
        Inositol phosphate metabolism
    Metabolic pathways
    Calcium signaling pathway
    Phosphatidylinositol signaling system


    PLCD3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLCD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/69 Interacting proteins for PLCD3 (Q8N3E92, 3 ENSP000003137314) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61689 I2D: score=3 
    DGKEENSP000002840614STRING: ENSP00000284061
    ITPR1ENSP000004059344STRING: ENSP00000405934
    ITPR3ENSP000003634354STRING: ENSP00000363435
    PIK3C3ENSP000002620394STRING: ENSP00000262039
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006629lipid metabolic process ----
    GO:0007165signal transduction ----
    GO:0016042lipid catabolic process IEA--
    GO:0035556intracellular signal transduction IEA--

    PLCD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLCD3 for compounds           About GeneDecksing

    EMD Millipore small molecules for PLCD3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PLCD3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    10/2478 HMDB Compounds for PLCD3 (see all 2478)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    2 Novoseek inferred chemical compound relationships for PLCD3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spermine 64.3 2 9799116 (2)
    calcium 12.6 3 9799116 (3)

    Search CenterWatch for drugs/clinical trials and news about PLCD3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLCD3 gene: 
    NM_133373.3  

    Unigene Cluster for PLCD3:

    Phospholipase C, delta 3
    Hs.380094  [show with all ESTs]
    Unigene Representative Sequence: AB075844
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540511 ENST00000539433 ENST00000543623 ENST00000544333 ENST00000545702
    ENST00000412978 ENST00000546350 ENST00000542173 ENST00000538988 ENST00000590644
    ENST00000538093 ENST00000544446 ENST00000322765(uc002iib.3)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCD3

    Additional mRNA sequence: 

    AB075844.1 AK074240.1 AL834392.1 BC010668.1 BC072384.1 

    11 DOTS entries:

    DT.100745002  DT.453507  DT.305818  DT.100751218  DT.100751220  DT.120953503  DT.100751217  DT.120953427 
    DT.95303308  DT.95303309  DT.40118642 

    24/211 AceView cDNA sequences (see all 211):

    BM752424 BF527922 AI799721 BU175788 BG831190 BP369723 BU159278 BU727979 
    BM744722 AL834392 F10653 BC072384 BM450532 NM_133373 AW297986 BE875430 
    BX331744 BI335227 AI419598 BM741682 BU538117 BF727195 BQ278137 BU552479 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PLCD3 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                            -                       -                                                                                       
    SP2:                                                                                                              -                                             
    SP3:        -     -                                                                                                                                             
    SP4:                                                                    -                                                                                       
    SP5:                                                                                                                                      -                     


    ECgene alternative splicing isoforms for PLCD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLCD3 expression in normal human tissues (normalized intensities)      PLCD3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PLCD3 Expression
    About this image


    PLCD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   
     
     Lower Urinary Tract (Urinary System)
             visceral organ   

    See PLCD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLCD3

    SOURCE GeneReport for Unigene cluster: Hs.380094

    UniProtKB/Swiss-Prot: PLCD3_HUMAN, Q8N3E9
    Tissue specificity: Present in corneal epithelial cells (at protein level)

        SABiosciences Custom PCR Arrays for PLCD3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PLCD3 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcd31 , 5 phospholipase C, delta 31, 5 85.65(n)1
    88.54(a)1
      11 (66.71 cM)5
    724691  NM_152813.31  NP_690026.21 
     1030703045 
    chicken
    (Gallus gallus)
    Aves PLCD31 phospholipase C, delta 3 71.5(n)
    65.92(a)
      428279  XM_425839.3  XP_425839.3 
    lizard
    (Anolis carolinensis)
    Reptilia PLCD36
    phospholipase C, delta 3
    63(a)
    1 ↔ 1
    6(64798969-64875323)
    zebrafish
    (Danio rerio)
    Actinopterygii plcd3a1 phospholipase C, delta 3a 60.19(n)
    53.94(a)
      569040  NM_001099423.1  NP_001092893.1 
    worm
    (Caenorhabditis elegans)
    Secernentea plc-41 Protein PLC-4 46(n)
    39.85(a)
      177525  NM_068812.2  NP_501213.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PLC11 phosphoinositide phospholipase C 3 45.34(n)
    36.2(a)
      830010  NM_120014.4  NP_195565.2 


    ENSEMBL Gene Tree for PLCD3 (if available)
    TreeFam Gene Tree for PLCD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLCD3 gene
    PLCD42  PLCD12  PLCE12  PLCB22  PLCZ12  PLCH12  PLCB32  PLCH22  
    PLCB12  PLCB42  PLCL12  PLCL22  
    12 SIMAP similar genes for PLCD3 using alignment to 7 protein entries:     PLCD3_HUMAN (see all proteins):
    DKFZp686K101    PLCD1    PLCD4    PLCL2    PLCZ1    PLCL1
    PLCB2    PLCH2    PLCB4    FLJ00414    PLCH1    PLCB1

    PLCD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/351 SNPs in PLCD3 are shown (see all 351)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849351951,2
    C--38974870(+) AGACTA/CCGTCT 1 -- int10--------
    rs1877976971,2
    --43188564(+) AGCAGC/TGTTTC 1 -- ds50010--------
    rs728328581,2
    C--43188723(+) CAAGGC/TCCCTC 1 -- ds50010--------
    rs1408435441,2
    C--43188742(+) TGTGA-/GTGTGTG 1 -- ds50010--------
    rs728328591,2
    C--43188891(+) GCCACC/GCCCTG 1 -- ds50012Minor allele frequency- G:0.16NA 122
    rs1494920051,2
    --43188907(+) CTTAGC/TCAAGT 1 -- ds50010--------
    rs739843241,2
    C,F--43188953(+) ATCCAG/TCCCTG 1 -- ds50012Minor allele frequency- T:0.07WA 120
    rs1459654711,2
    C--43188978(+) CCTGTC/GGGGGT 1 -- ds50010--------
    rs1443971371,2
    --43189032(+) GTGCTG/TCTTTA 1 -- ut310--------
    rs10521691,2
    C,F,A,H--43189049(-) CTATCT/GAGTTT 1 -- ut3126Minor allele frequency- G:0.13MN NS EA NA CSA 2938

    HapMap Linkage Disequilibrium report for PLCD3 (43186335 - 43210721 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PLCD3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv527788CNV Loss19592680
    nsv522514CNV Loss19592680
    nsv908300CNV Loss21882294
    nsv908297CNV Loss21882294
    dgv3178n71CNV Loss21882294
    dgv3179n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608795    OMIM disorders: --

    7 diseases for PLCD3:    About MalaCards
    neurologic diseases    huntington's disease    cholera    glioblastoma
    hypertension    breast cancer    neuronitis


    PLCD3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLCD3
    Human Genome Epidemiology (HuGE) Navigator: PLCD3 (8 documents)

    Export disorders for PLCD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLCD3 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with PLCD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization. (PubMed id 10702670)1, 2, 3, 9 Kim H.... Park S.H. (1999)
    2. Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties. (PubMed id 9056492)1, 2, 3 Ghosh S.... Lowenstein J.M. (1997)
    3. Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium. (PubMed id 9799116)1, 2, 9 Pawelczyk T. and Matecki A. (1998)
    4. Expression, purification and kinetic properties of human recombinant phospholipase C delta 3. (PubMed id 9360711)1, 2, 9 Pawelczyk T. and Matecki A. (1997)
    5. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (2009)
    8. Phosphoinositide cycle gene polymorphisms affect the plasma lipid profile in the Quebec Family Study. (PubMed id 19329342)1, 4 Dolley G....Vohl M.C. (2009)
    9. Membrane targeting of C2 domains of phospholipase C-delta isoforms. (PubMed id 11706040)1, 2 Ananthanarayanan B.... Cho W. (2002)
    10. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113026 HGNC: 9061 AceView: PLCD3 Ensembl:ENSG00000161714 euGenes: HUgn113026
    ECgene: PLCD3 Kegg: 113026 H-InvDB: PLCD3

    (According to HUGE)
    About This Section
    HUGE: KIAA1964

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLCD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLCD3 gene:
    Search GeneIP for patents involving PLCD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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