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Aliases for PLCD3 Gene

Aliases for PLCD3 Gene

  • Phospholipase C Delta 3 2 3 5
  • Phosphoinositide Phospholipase C-Delta-3 3 4
  • PLC-Delta-3 3 4
  • EC 3.1.4.11 4 61
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3 3
  • 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Delta-3 3
  • Phospholipase C, Delta 3 2
  • Phospholipase C-Delta-3 4
  • PLC Delta3 3
  • KIAA1964 4

External Ids for PLCD3 Gene

Previous GeneCards Identifiers for PLCD3 Gene

  • GC17U990190
  • GC17P045239
  • GC17M043197
  • GC17M043664
  • GC17M040544
  • GC17M038952
  • GC17M043186

Summaries for PLCD3 Gene

Entrez Gene Summary for PLCD3 Gene

  • This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLCD3 Gene

PLCD3 (Phospholipase C Delta 3) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and G-Beta Gamma Signaling. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCD1.

UniProtKB/Swiss-Prot for PLCD3 Gene

  • Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.

Tocris Summary for PLCD3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCD3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCD3 Gene

Genomics for PLCD3 Gene

Regulatory Elements for PLCD3 Gene

Enhancers for PLCD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F045089 1.8 FANTOM5 Ensembl ENCODE 23.2 +41.1 41149 4.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 DCAKD PLCD3 GFAP NMT1 ACBD4 HEXIM1 GPATCH8 ENSG00000224911 LOC102724391 EFTUD2
GH17F045196 1.3 Ensembl ENCODE 12.7 -64.4 -64439 2.0 HDGF MLX WRNIP1 ARID4B SIN3A ZNF2 ZNF207 ZNF143 DEK ZNF263 HEXIM1 PLCD3 ACBD4 DCAKD ENSG00000233483 ENSG00000267405 GC17P045196 FMNL1
GH17F045200 1.2 Ensembl ENCODE 12.7 -68.2 -68241 2.1 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 SP5 NFYC MIER2 HEXIM1 PLCD3 ACBD4 DCAKD LRRC37A4P ENSG00000233483 DND1P1 ENSG00000233175 CRHR1-IT1 ENSG00000267405
GH17F045121 1.6 FANTOM5 Ensembl ENCODE 9.3 +9.4 9402 4.0 HDGF ZFP64 ARID4B DMAP1 FOS ZNF263 SP5 JUNB REST KAT8 ACBD4 ENSG00000224505 HEXIM2 DCAKD PLCD3 SLC25A39 MIR6784
GH17F045157 1.2 ENCODE 12.3 -27.1 -27094 5.4 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ENSG00000267788 RN7SL405P SMCO4P1 LINC01180 ENSG00000265547 ENSG00000265964 RN7SL507P LOC102724391 PLCD3 ACBD4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLCD3 on UCSC Golden Path with GeneCards custom track

Promoters for PLCD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001347321 754 2001 HDGF ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 ZNF263 SP3 REST

Genomic Location for PLCD3 Gene

Chromosome:
17
Start:
45,108,967 bp from pter
End:
45,133,354 bp from pter
Size:
24,388 bases
Orientation:
Minus strand

Genomic View for PLCD3 Gene

Genes around PLCD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCD3 Gene

Proteins for PLCD3 Gene

  • Protein details for PLCD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3E9-PLCD3_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
    Protein Accession:
    Q8N3E9
    Secondary Accessions:
    • Q8TEC1
    • Q8TF37
    • Q96FL6

    Protein attributes for PLCD3 Gene

    Size:
    789 amino acids
    Molecular mass:
    89258 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLCD3 Gene

Selected DME Specific Peptides for PLCD3 Gene

Q8N3E9:
  • GCRCVELD
  • GYRHIHLLS
  • CGYVLKP
  • SIVDPLV
  • SSHNTYL
  • VALNFQT
  • YPVILSLE
  • LVRFVVEDYD
  • YHGHTLT

Post-translational modifications for PLCD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCD3 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for PLCD3

Domains & Families for PLCD3 Gene

Gene Families for PLCD3 Gene

Suggested Antigen Peptide Sequences for PLCD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N3E9

UniProtKB/Swiss-Prot:

PLCD3_HUMAN :
  • The C2 domain is a Ca(2+)-dependent membrane-targeting module.
Domain:
  • The C2 domain is a Ca(2+)-dependent membrane-targeting module.
  • The PH domain mediates interaction with the surface membrane by binding to PIP2.
  • Contains 1 C2 domain.
  • Contains 3 EF-hand domains.
  • Contains 1 PH domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCD3: view

Function for PLCD3 Gene

Molecular function for PLCD3 Gene

GENATLAS Biochemistry:
phospholipase C,delta 3,involved in signal transduction
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=105.3 uM for PIP2 {ECO:0000269 PubMed:10336610}; Vmax=28.5 umol/min/mg enzyme {ECO:0000269 PubMed:10336610};
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer).
UniProtKB/Swiss-Prot Function:
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
UniProtKB/Swiss-Prot Induction:
Down-regulated by Ca(2+) and cAMP.

Enzyme Numbers (IUBMB) for PLCD3 Gene

Gene Ontology (GO) - Molecular Function for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA,TAS --
GO:0004871 signal transducer activity IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLCD3: view
genes like me logo Genes that share phenotypes with PLCD3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCD3

miRNA for PLCD3 Gene

miRTarBase miRNAs that target PLCD3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCD3 Gene

Localization for PLCD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCD3 Gene

Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCD3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
cytosol 3

Gene Ontology (GO) - Cellular Components for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLCD3: view

Pathways & Interactions for PLCD3 Gene

genes like me logo Genes that share pathways with PLCD3: view

Interacting Proteins for PLCD3 Gene

Gene Ontology (GO) - Biological Process for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0016042 lipid catabolic process IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PLCD3: view

No data available for SIGNOR curated interactions for PLCD3 Gene

Drugs & Compounds for PLCD3 Gene

(5) Drugs for PLCD3 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diltiazem Approved Pharma Channel blocker 75
Water Approved Pharma 0
cyclic amp Experimental Pharma 0
calcium Nutra 0

(566) Additional Compounds for PLCD3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for PLCD3 Gene

Compound Action Cas Number
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCD3: view

Transcripts for PLCD3 Gene

Unigene Clusters for PLCD3 Gene

Phospholipase C, delta 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products