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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLCD1 Gene

protein-coding GIFtS: 67
GCID: GC03M038023

phospholipase C, delta 1

Explore 17 diseases affiliated with
PLCD1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Phospholipase C, Delta 1¹ ²		EC 3.1.4.11³ ⁸
Phosphoinositide Phospholipase C-Delta-1² ³		1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-1²
Phospholipase C-III² ³		1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Delta-1²
PLC-III² ³		NDNC3²
PLC-Delta-1¹		Phospholipase C-Delta-1³

External Ids:	HGNC: 9060¹	Entrez Gene: 5333²	Ensembl: ENSG00000187091⁷	OMIM: 602142⁵	UniProtKB: P51178³

ORGUL members:
	NONCODE:n406564

Export aliases for PLCD1 gene to outside databases

Previous GC identifers: GC03M037350 GC03U900338 GC03M038009

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLCD1:

This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular

signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second

messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor

in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced

transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: PLCD1_HUMAN, P51178

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and

placental development

summary for PLCD1:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the

hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and

1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily

activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth

factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological

functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane

phospholipids.

Gene Wiki entry for PLCD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLCD1 gene promoter:
p53 RelA NF-kappaB1 NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLCD1 promoter sequence

Search SABiosciences Chromatin IP Primers for PLCD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22-p21.3 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p22-p21.3

PLCD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCD1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M038023: view genomic region (about GC identifiers)

Start:	38,048,987 bp from pter	End:	38,071,253 bp from pter
Size:	22,267 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLCD1_HUMAN, P51178 (See protein sequence)

Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Size: 756 amino acids; 85665 Da

Cofactor: Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain (By similarity)

Secondary accessions: B3KR14 Q86VN8

Alternative splicing: 2 isoforms: P51178-1 P51178-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLCD1: NX_P51178

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51178

4/9 DME Specific Peptides for PLCD1 (P51178) (see all 9)

VALNFQT

KGCRCLE

CGYVLKP

SSHNTYL

PLCD1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001124436.1 NP_006216.2

ENSEMBL proteins:

ENSP00000430344 ENSP00000335600

Reactome Protein details: P51178
Human Recombinant Protein Products for PLCD1:

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	Novus Biologicals PLCD1 Protein Novus Biologicals PLCD1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	15702972
GO:0005829	cytosol	IEA	--

PLCD1 for ontologies About GeneDecksing

PLCD1 Antibody Products:

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	Novus Biologicals PLCD1 Antibodies
	Abcam antibodies for PLCD1
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for PLCD1

Assay Products for PLCD1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PLCD1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLCD1 for domains About GeneDecksing

5/13 InterPro domains/families (see all 13):

IPR015359 PLipase_C_EF-hand-like

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR001192 Pinositol_PLipase_C

IPR001849 Pleckstrin_homology

Graphical View of Domain Structure for InterPro Entry P51178

ProtoNet protein and cluster: P51178

3 Blocks protein families:

IPB000008 C2 domain

IPB000909 Phosphatidylinositol-specific phospholipase C

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: PLCD1_HUMAN, P51178

Similarity: Contains 1 C2 domain

Similarity: Contains 2 EF-hand domains

Similarity: Contains 1 PH domain

Similarity: Contains 1 PI-PLC X-box domain

Similarity: Contains 1 PI-PLC Y-box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PLCD1_HUMAN, P51178

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and

placental development

Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate +

diacylglycerol

Genatlas biochemistry entry for PLCD1:

phospholipase C,delta 1,involved in signal transduction

Enzyme Number (IUBMB): EC 3.1.4.11¹ ²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphatidylinositol phospholipase C activity	IEA	--
GO:0004871	signal transducer activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005543	phospholipid binding	IEA	--
GO:0032794	GTPase activating protein binding	IPI	18434237

PLCD1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PLCD1:

Increased G2M DNA content

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Plcd1):

cellular	endocrine/exocrine gland	growth/size	integument	reproductive system
tumorigenesis

PLCD1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Plcd1^tm1Tta for PLCD1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PLCD1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PLCD1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCD1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCD1:
		hsa-miR-191 hsa-miR-15a hsa-miR-497 hsa-miR-424 hsa-miR-195 hsa-miR-16 hsa-miR-1827 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: PLCD1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLCD1 (see all 7) OriGene shRNA RFP: PLCD1 OriGene siRNA: PLCD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCD1
		Sirion Biotech Custom design and validation of potent shRNA sequences against PLCD1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PLCD1
			Sirion Biotech Customized adenovirus for overexpression of PLCD1 Sirion Biotech Customized adenovirus for potent knockdown of PLCD1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLCD1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLCD1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PLCD1 (NM_001130964)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCD1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PLCD1
		Search LifeMap BioReagents cell lines for PLCD1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCD1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/34 super-pathways (see all 34) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sweet Taste Signaling

	Sweet Taste Signaling	1.00			Cellular Effects of Sildenafil	0.46
	Melatonin Signaling	0.72			Sperm Motility	0.36

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

CREB Pathway

	CREB Pathway	1.00			Activation of PKC through GPCR	0.63
	IP3 Pathway	0.68			Intracellular Calcium Signaling	0.50

NFAT and Cardiac Hypertrophy

	NFAT and Cardiac Hypertrophy	1.00			IGF1R Signaling	0.37
	Signaling Involved in Cardiac Hypertrophy	0.42

Inositol phosphate metabolism

	Inositol phosphate metabolism	1.00			Phosphatidylinositol signaling system	0.59
	superpathway of inositol phosphate compounds	0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for PLCD1

	Development Activation of ERK by Alpha-1 adrenergic receptors
	Cytoskeleton remodeling RalB regulation pathway
	Anandamide biosynthesis and metabolism
	G-protein signaling Rap1A regulation pathway

5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLCD1 (see all 38)

	Antioxidant Action of Vitamin-C
	Intracellular Calcium Signaling
	Aldosterone Signaling in Epithelial Cells
	UVA-Induced MAPK Signaling
	PACAP Signaling

4 GeneGo (Thomson Reuters) Pathways for PLCD1

	Anandamide biosynthesis and metabolism
	G-protein signaling Rap1A regulation pathway
	Cytoskeleton remodeling RalB regulation pathway
	Development Activation of ERK by Alpha-1 adrenergic receptors

5 BioSystems Pathways for PLCD1

	Myometrial Relaxation and Contraction Pathways
	D-myo-inositol-5-phosphate metabolism
	D-myo-inositol (1,4,5)-trisphosphate biosynthesis
	phospholipases
	superpathway of inositol phosphate compounds

3 Reactome Pathways for PLCD1

	Metabolism
	Inositol phosphate metabolism
	Synthesis of IP3 and IP4 in the cytosol

1 PharmGKB Pathway for PLCD1

Proton Pump Inhibitor Pathway, Pharmacodynamics

4 Kegg Pathways (Kegg details for PLCD1):

	Inositol phosphate metabolism
	Metabolic pathways
	Calcium signaling pathway
	Phosphatidylinositol signaling system

PLCD1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PLCD1

5/9 Interacting proteins for PLCD1 (P51178^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KPNB1	Q14974²^,³	MINT-62860 MINT-62861 MINT-62859 MINT-62862 I2D: score=2
TGM2	P21980²^,³	MINT-15193 I2D: score=4
CALM1	P62158³	I2D: score=2
CALM2	P62158³	I2D: score=2
CALM3	P62158³	I2D: score=2

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0006644	phospholipid metabolic process	TAS	9588182
GO:0016042	lipid catabolic process	IEA	--
GO:0035556	intracellular signal transduction	IEA	--
GO:0042127	regulation of cell proliferation	IEA	--

PLCD1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PLCD1 for compounds About GeneDecksing

EMD Millipore small molecules for PLCD1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLCD1 available from Tocris Bioscience About this table

Compound	Action	CAS #
m-3M3FBS	Phospholipase C activator	[200933-14-8]
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
U 73122	Phospholipase C inhibitor	[112648-68-7]
D609	Selective PC-PLC inhibitor	[83373-60-8]

10/1223 HMDB Compounds for PLCD1 (see all 1223) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--

2 DrugBank Compounds for PLCD1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
D-Myo-Inositol-1,4,5-Triphosphate	--	--	target	--	17139284 17016423 10592235
D-Myo-Inositol-2,4,5-Trisphosphate	--	--	target	--	17139284 17016423 10592235

10/16 Novoseek chemical compound relationships for PLCD1 gene (see all 16) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pip2	80.2	14	7890667 (3), 8810295 (2), 8798711 (2), 1334430 (1)
pl-cs	77.6	1	7893368 (1)
inositol 1,4,5 trisphosphate	70.7	7	18665913 (1), 16246104 (1), 8294445 (1), 7479822 (1) (see all 7)
phosphatidylinositol	52.6	7	8810295 (2), 8798711 (2), 12761218 (1)
inositol	49.2	2	9417098 (1), 10785396 (1)
phospholipid	47.1	9	18359940 (2), 8387776 (2), 8942652 (1), 8519781 (1) (see all 6)
phosphatidylcholine	47	8	10419523 (3), 12576304 (1), 1334430 (1)
phosphoinositide	46.1	4	9920735 (1), 12576304 (1), 12771127 (1)
spermine	35.9	7	9251249 (4), 8435099 (1), 9360711 (1)
phosphatidylserine	35.9	6	10419523 (4), 1334430 (1)

Search CenterWatch for drugs/clinical trials and news about PLCD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLCD1 gene (2 alternative transcripts):

NM_001130964.1 NM_006225.3

Unigene Cluster for PLCD1:

Phospholipase C, delta 1

Hs.80776 [show with all ESTs]

Unigene Representative Sequence: NR_024071

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000417185 ENST00000461445 ENST00000463876(uc003chm.3) ENST00000334661(uc003chn.3)

ENST00000495395 ENST00000484829 ENST00000495367 ENST00000479619 ENST00000473834

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PLCD1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCD1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCD1:
		hsa-miR-191 hsa-miR-15a hsa-miR-497 hsa-miR-424 hsa-miR-195 hsa-miR-16 hsa-miR-1827 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: PLCD1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLCD1 (see all 7) OriGene shRNA RFP: PLCD1 OriGene siRNA: PLCD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCD1
		Sirion Biotech Custom design and validation of potent shRNA sequences against PLCD1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLCD1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLCD1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PLCD1 (NM_001130964)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCD1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLCD1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PLCD1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLCD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCD1

Additional cDNA sequence:

AB209862.1 AK090774.1 AK098690.1 AK127813.1 AK292324.1 BC050382.1 NR_024071.1 U09117.1

10 DOTS entries:

DT.100778614 DT.313996 DT.97772899 DT.100778609 DT.91923269 DT.100657786 DT.97842902 DT.100733962

DT.120876807 DT.120876812

24/131 AceView cDNA sequences (see all 131):

BI753236 BX647927 BQ001499 CD368470 CR613815 BM720447 BU625195 AL705006

BQ647520 BC050382 BE884735 AI473335 BI769983 AK090774 AX746610 BU740372

BQ277711 BI489731 AI082772 BQ890375 BU859101 BI828021 BX103148 BP364646

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PLCD1 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	^	8	^	9	^	10	^	11	^	12	^	13	^
SP1:							-		-		-										-
SP2:											-										-
SP3:
SP4:							-		-		-										-		-
SP5:

ExUns:	14a	·	14b	^	15a	·	15b	^	16a	·	16b	^	17	^	18
SP1:					-
SP2:					-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PLCD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLCD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGGACAGG

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PLCD1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Thoracic Rib

Bone

Kidney

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See PLCD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLCD1

SOURCE GeneReport for Unigene cluster: Hs.80776

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCD1 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLCD1¹	phospholipase C, delta 1	68.65(n) 68.65(a)		420416 XM_418522.3 XP_418522.2
lizard (Anolis carolinensis)	Reptilia	PLCD1⁶	--	68(a)	1 ↔ 1	6(1089644-1127886)
zebrafish (Danio rerio)	Actinopterygii	wufj78d10²	wufj78d10	76.27(n)		337489 BC051157.1
worm (Caenorhabditis elegans)	Secernentea	plc-4⁶	PhosphoLipase C family member (plc-4)	32(a)	possible ortholog	IV(7509454-7512662)
thale cress (Arabidopsis thaliana)	eudicotyledons	PLC5¹	phosphoinositide phospholipase C 5	42.82(n) 32.83(a)		835983 NM_125256.2 NP_200677.2
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	phospholipase C, putative, expressed (see all 4)	26(a) 25(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(10024184-10026867) 12(23015165-23019784)

ENSEMBL Gene Tree for PLCD1 (if available)
TreeFam Gene Tree for PLCD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PLCD1 gene

PLCG2² PLCD4² PLCG1² PLCB2² PLCZ1² PLCB3² PLCH1² PLCD3²

PLCB1² PLCB4² PLCH2² PLCL1² PLCL2²

9 SIMAP similar genes for PLCD1 using alignment to 1 protein entry: PLCD1_HUMAN:

DKFZp686K101 PLCD3 PLCD4 PLCL2 PLCZ1 PLCL1

PLCB1 PLCB2 PLCB4

PLCD1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73825459^1,2	C,F	--	37991363(+)	`CCATAC/GGAGCT`	3	--	ds500¹		3		WA CSA	122
rs2364785^1,2	A	--	37992874(+)	`GGCCTA/TAGAGC`	3	--	int¹		0	--	--	--	--
rs73060833^1,2	C,F	--	37993010(+)	`TCCTGG/CTGTGA`	3	--	int¹		4		NA CSA WA	242
rs4679014^1,2	C,H	--	37993229(+)	`CCATAC/ACGATC`	3	--	spd¹ spl³		4		NS EA	418
rs113896726^1,2	C,F	--	37993309(+)	`ATTCTG/ACTCAG`	5	/S	syn¹		2		NA	4510
rs111762793^1,2	F	--	37993415(+)	`CCAATG/TCTCTC`	3	--	int¹		2		CSA	4
rs9842880^1,2	C,F	--	37995310(+)	`CTCCGG/CTTCCC`	3	--	int¹		8		WA NA CSA EA	369
rs12491220^1,2	H	--	37995902(+)	`GGAACC/TTACCA`	3	--	int¹		0	--	--	--	--
rs76520765^1,2		--	37995978(+)	`CTGACT/CTACTA`	3	--	int¹		1		EA	120
rs76329266^1,2	C	--	37996250(+)	`TCACTC/TTGTCG`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLCD1 (38048987 - 38071253 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PLCD1
1 CNV: 3425
Human Gene Mutation Database (HGMD): PLCD1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLCD1 for disorders About GeneDecksing

OMIM gene information: 602142 OMIM disorders: --

UniProtKB/Swiss-Prot: PLCD1_HUMAN, P51178

Defects in PLCD1 are the cause of nail disorder non-syndromic congenital type 3 (NDNC3) [MIM:151600]. NDNC3 is

a nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed

(pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis)

or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata)

or white spots (leukonychia punctata)

17 diseases for PLCD1: About MalaCards

leukonychia totalis esophageal squamous cell carcinoma squamous cell carcinoma neurologic diseases

insulinoma colon carcinoma alzheimer's disease esophagitis

gastric cancer carcinoma breast carcinoma breast cancer

hypertension immunodeficiency neuronitis huntington's disease

glioblastoma

1 disease from the University of Copenhagen DISEASES database for PLCD1:

Nail disease

1 Novoseek disease relationship for PLCD1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	3.79	2	8435099 (1), 19448674 (1)

Human Genome Epidemiology (HuGE) Navigator: PLCD1 (8 documents)

Export disorders for PLCD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLCD1 gene, integrated from 9 sources (see all 130):
(articles sorted by number of sources associating them with PLCD1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis. (PubMed id 7890667)^{1, 2, 9} Cheng H.F....King K. (1995)
Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22-->p21.3. (PubMed id 9345909)^{1, 3, 9} Ishikawa S....Nakamura Y. (1997)
Hereditary leukonychia, or porcelain nails, resulting from mutations in PLCD1. (PubMed id 21665001)^{1, 2} Kiuru M....Christiano A.M. (2011)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site. (PubMed id 12761218)^{1, 9} Guo Y....Scarlata S. (2003)
Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site. (PubMed id 14550290)^{1, 9} Kim J.Y....Rha H.K. (2003)
Interactions of G(h)/transglutaminase with phospholipase Cdelta1 and with GTP. (PubMed id 10518533)^{1, 9} Murthy S.N....Lorand L. (1999)
Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin. (PubMed id 15817490)^{1, 9} Sidhu R.S....Bhullar R.P. (2005)
Phospholipase Cdelta1 associates with importin beta1 and translocates into the nucleus in a Ca2+-dependent manner. (PubMed id 16115628)^{1, 9} Okada M....Yagisawa H. (2005)
Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension. (PubMed id 18434237)^{1, 9} Ochocka A.M....Pawelczyk T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5333	HGNC: 9060	AceView: PLCD1	Ensembl:ENSG00000187091	euGenes: HUgn5333
ECgene: PLCD1	Kegg: 5333	H-InvDB: PLCD1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PLCD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PLCD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PLCD1 gene:
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GeneCards and IP:
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phospholipase C, delta 1

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PLCD1 Gene

phospholipase C, delta 1

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