Aliases for PLCB4 Gene
- Phospholipase C, Beta 4 2 3
- Phosphoinositide Phospholipase C-Beta-4 3 4
- EC 220.127.116.11 4 64
- PLC-Beta-4 3 4
- ARCND2 3 6
- DJ1119D9.2 (Phopholipase C, Beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4)) 3
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 3
- 1-Phosphatidyl-D-Myo-Inositol-4,5-Bisphosphate 3
External Ids for PLCB4 Gene
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
GeneCards Summary for PLCB4 Gene
PLCB4 (Phospholipase C, Beta 4) is a Protein Coding gene. Diseases associated with PLCB4 include auriculocondylar syndrome 2 and auriculo-condylar syndrome. Among its related pathways are GPCR Pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding and phosphatidylinositol phospholipase C activity. An important paralog of this gene is PLCH1.
UniProtKB/Swiss-Prot for PLCB4 Gene
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.