Aliases for PLCB4 Gene
- Phospholipase C Beta 4 2 3 5
- Phosphoinositide Phospholipase C-Beta-4 3 4
- Phospholipase C, Beta 4 2 3
- EC 220.127.116.11 4 63
- PLC-Beta-4 3 4
- DJ1119D9.2 (Phopholipase C, Beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4)) 3
- 1-Phosphatidyl-D-Myo-Inositol-4,5-Bisphosphate 3
- Monophosphatidylinositol Phosphodiesterase 3
External Ids for PLCB4 Gene
Previous GeneCards Identifiers for PLCB4 Gene
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
GeneCards Summary for PLCB4 Gene
PLCB4 (Phospholipase C Beta 4) is a Protein Coding gene. Diseases associated with PLCB4 include Auriculocondylar Syndrome 2 and Auriculo-Condylar Syndrome. Among its related pathways are Platelet activation and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCB3.
UniProtKB/Swiss-Prot for PLCB4 Gene
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.