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Aliases for PLCB3 Gene

Aliases for PLCB3 Gene

  • Phospholipase C, Beta 3 (Phosphatidylinositol-Specific) 2 3
  • Phosphoinositide Phospholipase C-Beta-3 3 4
  • EC 4 63
  • PLC-Beta-3 3 4
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 3
  • Phospholipase C-Beta-3 4
  • PLC Beta 3 3

External Ids for PLCB3 Gene

Summaries for PLCB3 Gene

Entrez Gene Summary for PLCB3 Gene

  • This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for PLCB3 Gene

PLCB3 (Phospholipase C, Beta 3 (Phosphatidylinositol-Specific)) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is PLCH1.

UniProtKB/Swiss-Prot for PLCB3 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes

Tocris Summary for PLCB3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLCB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCB3 Gene

Genomics for PLCB3 Gene

Genomic Location for PLCB3 Gene

64,251,523 bp from pter
64,269,452 bp from pter
17,930 bases
Plus strand

Genomic View for PLCB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLCB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCB3 Gene

Regulatory Elements for PLCB3 Gene

Proteins for PLCB3 Gene

  • Protein details for PLCB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
    Protein Accession:
    Secondary Accessions:
    • A5PKZ6
    • G5E960
    • Q8N1A4

    Protein attributes for PLCB3 Gene

    1234 amino acids
    Molecular mass:
    138799 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with SHANK2 (By similarity). Interacts with LPAR2.
    • Sequence=AAH32659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLCB3 Gene

    Alternative splice isoforms for PLCB3 Gene


neXtProt entry for PLCB3 Gene

Proteomics data for PLCB3 Gene at MOPED

Post-translational modifications for PLCB3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys804

Other Protein References for PLCB3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PLCB3 Gene

Gene Families for PLCB3 Gene

Suggested Antigen Peptide Sequences for PLCB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.:
    • Q01970
  • Contains 1 PI-PLC X-box domain.:
    • Q01970
  • Contains 1 PI-PLC Y-box domain.:
    • Q01970
genes like me logo Genes that share domains with PLCB3: view

Function for PLCB3 Gene

Molecular function for PLCB3 Gene

GENATLAS Biochemistry: phospholipase C,beta 3,phosphatidyl inositol specific,involved in signal transduction,excluded as a candidate in the tumorigenesis of endocrine tumor (see MEN1)
UniProtKB/Swiss-Prot CatalyticActivity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
UniProtKB/Swiss-Prot Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes

Enzyme Numbers (IUBMB) for PLCB3 Gene

Gene Ontology (GO) - Molecular Function for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004629 phospholipase C activity TAS 7607669
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PLCB3: view
genes like me logo Genes that share phenotypes with PLCB3: view

Animal Models for PLCB3 Gene

MGI Knock Outs for PLCB3:

miRNA for PLCB3 Gene

miRTarBase miRNAs that target PLCB3

No data available for Transcription Factor Targeting and HOMER Transcription for PLCB3 Gene

Localization for PLCB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCB3 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for PLCB3 Gene COMPARTMENTS Subcellular localization image for PLCB3 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0043234 protein complex IDA 18468998
genes like me logo Genes that share ontologies with PLCB3: view

Pathways for PLCB3 Gene

genes like me logo Genes that share pathways with PLCB3: view

Gene Ontology (GO) - Biological Process for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003073 regulation of systemic arterial blood pressure IDA 18468998
GO:0006629 lipid metabolic process --
GO:0007165 signal transduction --
GO:0007268 synaptic transmission TAS --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLCB3: view

Compounds for PLCB3 Gene

(5) Tocris Compounds for PLCB3 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
FIPI Phospholipase D inhibitor [939055-18-2]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]

(1226) HMDB Compounds for PLCB3 Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
  • Ca
  • DAG(14:0/14:0)
Not Available
  • DAG(14:0/14:1)
Not Available
  • Diacylglycerol(29:0)
Not Available

(8) Novoseek inferred chemical compound relationships for PLCB3 Gene

Compound -log(P) Hits PubMed IDs
pl-cs 74.6 1
inositol 1,4,5 trisphosphate 65.9 2
phosphoinositide 63.8 6
dpdpe 48.2 7
fmlp 47.8 3
genes like me logo Genes that share compounds with PLCB3: view

Transcripts for PLCB3 Gene

Unigene Clusters for PLCB3 Gene

Phospholipase C, beta 3 (phosphatidylinositol-specific):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCB3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
SP6: -
SP7: -
SP10: - - -

ExUns: 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30

Relevant External Links for PLCB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLCB3 Gene

mRNA expression in normal human tissues for PLCB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCB3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLCB3 Gene

SOURCE GeneReport for Unigene cluster for PLCB3 Gene Hs.523761

genes like me logo Genes that share expressions with PLCB3: view

No data available for mRNA Expression by UniProt/SwissProt for PLCB3 Gene

Orthologs for PLCB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLCB3 35
  • 99.32 (n)
  • 99.68 (a)
PLCB3 36
  • 100 (a)
(Bos Taurus)
Mammalia PLCB3 35
  • 89.59 (n)
  • 92.68 (a)
PLCB3 36
  • 93 (a)
(Canis familiaris)
Mammalia PLCB3 35
  • 89.24 (n)
  • 93.33 (a)
PLCB3 36
  • 94 (a)
(Mus musculus)
Mammalia Plcb3 35
  • 86.81 (n)
  • 92.3 (a)
Plcb3 16
Plcb3 36
  • 92 (a)
(Monodelphis domestica)
Mammalia PLCB3 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia PLCB3 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Plcb3 35
  • 87.03 (n)
  • 93.03 (a)
(Anolis carolinensis)
Reptilia PLCB3 36
  • 72 (a)
African clawed frog
(Xenopus laevis)
Amphibia PLC1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia plcb3 35
  • 64.92 (n)
  • 69.31 (a)
Str.18841 35
(Danio rerio)
Actinopterygii plcb3 35
  • 62.49 (n)
  • 61.64 (a)
plcb3 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Plc21C 36
  • 37 (a)
Plc21C 37
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for PLCB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLCB3 Gene

Gene Tree for PLCB3 (if available)
Gene Tree for PLCB3 (if available)

Paralogs for PLCB3 Gene

Paralogs for PLCB3 Gene

Selected SIMAP similar genes for PLCB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLCB3: view

Variants for PLCB3 Gene

Sequence variations from dbSNP and Humsavar for PLCB3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs588177 -- 64,256,584(-) GCTGG(G/T)GTCCC intron-variant
rs589030 -- 64,264,326(-) CCACT(C/G)CAAGC intron-variant
rs599908 -- 64,256,280(-) GCCTG(C/G)CCCTG intron-variant
rs621816 -- 64,268,255(-) AAGAT(A/G)CTAGG utr-variant-3-prime, intron-variant
rs632439 -- 64,254,987(-) TTCAC(C/T)GGGTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PLCB3 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
dgv1167n71 CNV Loss 21882294

Relevant External Links for PLCB3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCB3 Gene

Disorders for PLCB3 Gene

(1) University of Copenhagen DISEASES for PLCB3 Gene

(4) Novoseek inferred disease relationships for PLCB3 Gene

Disease -log(P) Hits PubMed IDs
multiple endocrine neoplasia type 1 76 10
multiple endocrine neoplasia 51.9 1
pancreatic tumor 29.9 1
tumors 0 1

Relevant External Links for PLCB3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PLCB3: view

No data available for UniProtKB/Swiss-Prot for PLCB3 Gene

Publications for PLCB3 Gene

  1. The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours. (PMID: 7849701) Weber G. … Teh B.T. (Hum. Mol. Genet. 1994) 2 3 23
  2. Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3). (PMID: 7607669) Lagercrantz J. … Weber G. (Genomics 1995) 3 4 23
  3. Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene. (PMID: 7612006) Mazuruk K. … Rodriguez I.R. (Biochem. Biophys. Res. Commun. 1995) 3 4 23
  4. Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene. (PMID: 11178984) StAYlberg P. … Skogseid B. (Biochem. Biophys. Res. Commun. 2001) 3 23
  5. Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases. (PMID: 11278298) Xia C. … Liu M. (J. Biol. Chem. 2001) 3 23

Products for PLCB3 Gene

Sources for PLCB3 Gene

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