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Aliases for PLCB3 Gene

Aliases for PLCB3 Gene

  • Phospholipase C Beta 3 2 3 5
  • EC 3.1.4.11 4 61
  • Phospholipase C, Beta 3 (Phosphatidylinositol-Specific) 2
  • Phosphoinositide Phospholipase C-Beta-3 4
  • Phospholipase C-Beta-3 4
  • PLC-Beta-3 4

External Ids for PLCB3 Gene

Previous GeneCards Identifiers for PLCB3 Gene

  • GC11P066534
  • GC11P065700
  • GC11P064269
  • GC11P063794
  • GC11P063775
  • GC11P064019
  • GC11P060321

Summaries for PLCB3 Gene

Entrez Gene Summary for PLCB3 Gene

  • This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for PLCB3 Gene

PLCB3 (Phospholipase C Beta 3) is a Protein Coding gene. Diseases associated with PLCB3 include Multiple Endocrine Neoplasia 1. Among its related pathways are Signaling by GPCR and Presynaptic function of Kainate receptors. GO annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is PLCB1.

UniProtKB/Swiss-Prot for PLCB3 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Tocris Summary for PLCB3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCB3 Gene

Genomics for PLCB3 Gene

Regulatory Elements for PLCB3 Gene

Enhancers for PLCB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F064354 1.4 FANTOM5 ENCODE 25.2 +106.5 106452 6.6 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A ZNF207 ZNF143 FOS PLCB3 LOC102723878 ZFPL1 ENSG00000257086 POLA2 VPS51 ATG2A CDC42BPG MRPL49 SNX15
GH11F064089 1.7 FANTOM5 Ensembl ENCODE 17.2 -158.5 -158523 6.4 PKNOX1 MLX ARID4B DMAP1 YY1 ZNF766 ZNF548 FOS SP5 NFYC PLCB3 ENSG00000256341 ZFPL1 C11orf84 TRPT1 CCDC88B VEGFB ENSG00000257086 LOC102723878 NRXN2
GH11F064267 1.2 ENCODE 22.9 +19.2 19177 7.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZFPL1 TRMT112 PLCB3 POLA2 LOC102723878 FAU MRPL49 TRPT1 ENSG00000257086 C11orf84
GH11F064320 0.9 ENCODE 28.3 +71.6 71597 5.3 HDAC1 KLF17 NFXL1 RAD21 ZNF366 SCRT2 EGR2 ZNF263 ZBTB2 CEBPB PLCB3 LOC102723878 TEX40 ENSG00000207024 KCNK4 KCNK4-TEX40 BAD GPR137 ENSG00000257086 TRMT112
GH11F064205 1.1 ENCODE 22.4 -43.9 -43928 4.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 TRPT1 PLCB3 TRMT112 ZFPL1 ENSG00000257086 GPR137 BAD KCNK4 KCNK4-TEX40 ENSG00000207024
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLCB3 on UCSC Golden Path with GeneCards custom track

Promoters for PLCB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000563589 377 2201 HDGF HDAC1 CBX3 INSM2 ZNF76 KLF17 SIN3A ZBTB40 RAD21 GLIS2

Genomic Location for PLCB3 Gene

Chromosome:
11
Start:
64,251,523 bp from pter
End:
64,269,452 bp from pter
Size:
17,930 bases
Orientation:
Plus strand

Genomic View for PLCB3 Gene

Genes around PLCB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCB3 Gene

Proteins for PLCB3 Gene

  • Protein details for PLCB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01970-PLCB3_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
    Protein Accession:
    Q01970
    Secondary Accessions:
    • A5PKZ6
    • G5E960
    • Q8N1A4

    Protein attributes for PLCB3 Gene

    Size:
    1234 amino acids
    Molecular mass:
    138799 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with SHANK2 (By similarity). Interacts with LPAR2.
    SequenceCaution:
    • Sequence=AAH32659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLCB3 Gene

    Alternative splice isoforms for PLCB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCB3 Gene

Selected DME Specific Peptides for PLCB3 Gene

Q01970:
  • KRVETAL
  • GCRCVELD
  • YVEVDMFGLPVDTRRK
  • FEMSSFVETK
  • KVVLPTLA
  • GHRILPV
  • EQLTKSP
  • RVDSSNY
  • EFMRRPDK
  • KAYTKLKLQV
  • IVDGIVAN
  • SSVEMYRQ
  • ITHGFTMTT
  • RIYPKGTR
  • QQAKMAEYCR
  • EFVEYNK
  • QLSRIYP
  • LKPEFMRR
  • ISGQFLS
  • SSHNTYL
  • VALNFQT
  • LSFENHVDS
  • DVLEAIAE
  • DSSNYMPQ

Post-translational modifications for PLCB3 Gene

  • Ubiquitination at Lys 804
  • Modification sites at PhosphoSitePlus

Other Protein References for PLCB3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLCB3 (PLCB3)
  • Cloud-Clone Corp. Antibodies for PLCB3

Domains & Families for PLCB3 Gene

Gene Families for PLCB3 Gene

Suggested Antigen Peptide Sequences for PLCB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01970

UniProtKB/Swiss-Prot:

PLCB3_HUMAN :
  • Contains 1 C2 domain.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCB3: view

Function for PLCB3 Gene

Molecular function for PLCB3 Gene

GENATLAS Biochemistry:
phospholipase C,beta 3,phosphatidyl inositol specific,involved in signal transduction,excluded as a candidate in the tumorigenesis of endocrine tumor (see MEN1)
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Enzyme Numbers (IUBMB) for PLCB3 Gene

Gene Ontology (GO) - Molecular Function for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS --
GO:0004629 phospholipase C activity TAS 7607669
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005516 calmodulin binding IPI 12821674
genes like me logo Genes that share ontologies with PLCB3: view
genes like me logo Genes that share phenotypes with PLCB3: view

Animal Models for PLCB3 Gene

MGI Knock Outs for PLCB3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCB3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLCB3 Gene

Localization for PLCB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCB3 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCB3 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0016020 membrane IEA --
GO:0043234 protein complex IDA 18468998
genes like me logo Genes that share ontologies with PLCB3: view

Pathways & Interactions for PLCB3 Gene

genes like me logo Genes that share pathways with PLCB3: view

Pathways by source for PLCB3 Gene

SIGNOR curated interactions for PLCB3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003073 regulation of systemic arterial blood pressure IDA 18468998
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
GO:0007268 chemical synaptic transmission IEA --
genes like me logo Genes that share ontologies with PLCB3: view

Drugs & Compounds for PLCB3 Gene

(5) Drugs for PLCB3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
calcium Nutra 0

(391) Additional Compounds for PLCB3 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for PLCB3 Gene

Compound Action Cas Number
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCB3: view