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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLCB3 Gene

protein-coding   GIFtS: 71
GCID: GC11P064019

Phospholipase C, Beta 3 (Phosphatidylinositol-Specific)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase C, Beta 3 (Phosphatidylinositol-Specific)1 2     1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-32
Phosphoinositide Phospholipase C-Beta-32 3     PLC Beta 32
PLC-beta-32 3     Phospholipase C-Beta-33
EC 3.1.4.113 8     

External Ids:    HGNC: 90561   Entrez Gene: 53312   Ensembl: ENSG000001497827   OMIM: 6002305   UniProtKB: Q019703   

Export aliases for PLCB3 gene to outside databases

Previous GC identifers: GC11P066534 GC11P065700 GC11P064269 GC11P063794 GC11P063775 GC11P060321


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLCB3 Gene:
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production
of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in
G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript
variants.(provided by RefSeq, May 2010)

GeneCards Summary for PLCB3 Gene: 
PLCB3 (phospholipase C, beta 3 (phosphatidylinositol-specific)) is a protein-coding gene. Diseases associated with PLCB3 include wermer syndrome, and multiple endocrine neoplasia, and among its related super-pathways are fMLP Pathway and Prostacyclin signalling through prostacyclin receptor. GO annotations related to this gene include calmodulin binding and calcium ion binding. An important paralog of this gene is PLCD4.

UniProtKB/Swiss-Prot: PLCB3_HUMAN, Q01970
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
(IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes

summary for PLCB3 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLCB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLCB3 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   E2F   E2F-1   SEF-1 (1)   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLCB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

PLCB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCB3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064019:  view genomic region     (about GC identifiers)

Start:
64,018,995 bp from pter      End:
64,036,924 bp from pter
Size:
17,930 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLCB3_HUMAN, Q01970 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3  
Size: 1234 amino acids; 138799 Da
Cofactor: Calcium
Subunit: Interacts with SHANK2 (By similarity). Interacts with LPAR2
Subcellular location: Membrane; Peripheral membrane protein
Sequence caution: Sequence=AAH32659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for PLCB3:
3OHM (3D)        4GNK (3D)    
Secondary accessions: A5PKZ6 G5E960 Q8N1A4
Alternative splicing: 2 isoforms:  Q01970-1   Q01970-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLCB3: NX_Q01970

Explore proteomics data for PLCB3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01970

  • 4/24 DME Specific Peptides for PLCB3 (Q01970) (see all 24)
     RVDSSNY  EFVEYNK  KRVETAL  VALNFQT 

    PLCB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLCB3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000923.1  NP_001171812.1  

    ENSEMBL proteins: 
     ENSP00000279230   ENSP00000443631   ENSP00000324660  
    Reactome Protein details: Q01970
    Human Recombinant Protein Products for PLCB3: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--
    GO:0043234protein complex IDA18468998

    PLCB3 for ontologies           About GeneDecksing



    PLCB3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: PLCβ3 
    Phosphoinositide-specific phospholipase C

    5/13 InterPro protein domains (see all 13):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-like_dom
     IPR001192 Pinositol_PLipase_C
     IPR018029 C2_membr_targeting
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q01970

    ProtoNet protein and cluster: Q01970

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C


    UniProtKB/Swiss-Prot: PLCB3_HUMAN, Q01970
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain


    PLCB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCB3_HUMAN, Q01970
    Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
    (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
    + diacylglycerol

         Genatlas biochemistry entry for PLCB3:
    phospholipase C,beta 3,phosphatidyl inositol specific,involved in signal transduction,excluded as a candidate in
    the tumorigenesis of endocrine tumor (see MEN1)

         Enzyme Number (IUBMB): EC 3.1.4.111 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IEA--
    GO:0004629phospholipase C activity TAS7607669
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    PLCB3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PLCB3:
     Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Plcb3):
     behavior/neurological  embryogenesis  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging 

    PLCB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PLCB3: Plcb3tm1Dwu Plcb3tm1Sko

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLCB3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLCB3 
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLCB3 About   (see all 76)                                                                                              See pathways by source

    SuperPathContained pathways About
    1fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    2Prostacyclin signalling through prostacyclin receptor
    G-protein beta:gamma signalling0.89
    Activation of Kainate Receptors upon glutamate binding0.70
    G beta:gamma signalling through PLC beta0.77
    G-Protein Signaling through Tubby Protein0.38
    Presynaptic function of Kainate receptors0.74
    3Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin-1/EDNRA transactivation of EGFR0.41
    Estrogen signaling pathway0.34
    Cytoskeleton remodeling FAK signaling0.41
    4Ca-dependent events
    PLC beta mediated events0.65
    Opioid Signalling0.55
    G-protein mediated events0.64
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    5Anandamide biosynthesis and metabolism
    D-myo-inositol-5-phosphate metabolism0.50
    Anandamide biosynthesis and metabolism0.34
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.50
    phospholipases0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/22 EMD Millipore Pathways for PLCB3 (see all 22)
        Transcription Transcription factor Tubby signaling pathways
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling
    Cytoskeleton remodeling FAK signaling
    Signal transduction IP3 signaling

    1 R&D Systems Pathway for PLCB3
        Wnt Signaling Pathway

    5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLCB3 (see all 55)
        Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for PLCB3
        Ca, cAMP and Lipid Signaling

    5/23 GeneGo (Thomson Reuters) Pathways for PLCB3 (see all 23)
        Anandamide biosynthesis and metabolism
    Development Endothelin-1/EDNRA transactivation of EGFR
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation

    5/14 BioSystems Pathways for PLCB3 (see all 14)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Signal Transduction of S1P Receptor
    Calcium Regulation in the Cardiac Cell
    MAPK Cascade

    5/23        Reactome Pathways for PLCB3 (see all 23)
        Activation of Kainate Receptors upon glutamate binding
    Transmission across Chemical Synapses
    Metabolism
    Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
    Regulation of Insulin Secretion

    3 PharmGKB Pathways for PLCB3
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/30         Kegg Pathways  (Kegg details for PLCB3) (see all 30):
        Inositol phosphate metabolism
    Metabolic pathways
    Calcium signaling pathway
    Chemokine signaling pathway
    Phosphatidylinositol signaling system


    PLCB3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLCB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/250 Interacting proteins for PLCB3 (Q019702, 3 ENSP000002792304) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3, ENSP000003639214MINT-62362 MINT-62354 MINT-62363 MINT-62358 MINT-62361 I2D: score=3 STRING: ENSP00000363921
    EZRP153112, 3, ENSP000003389344MINT-73254 I2D: score=1 STRING: ENSP00000338934
    SLC9A3R1O147452, 3, ENSP000002626134MINT-73251 I2D: score=1 STRING: ENSP00000262613
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    PARD6AQ9NPB62, 3, ENSP000002192554MINT-62359 MINT-62355 I2D: score=3 STRING: ENSP00000219255
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003073regulation of systemic arterial blood pressure IDA18468998
    GO:0006629lipid metabolic process ----
    GO:0007165signal transduction ----
    GO:0007268synaptic transmission TAS--
    GO:0016042lipid catabolic process IEA--

    PLCB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLCB3 for compounds           About GeneDecksing

    EMD Millipore small molecules for PLCB3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PLCB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    10/1226 HMDB Compounds for PLCB3 (see all 1226)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    8 Novoseek inferred chemical compound relationships for PLCB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pl-cs 74.6 1 11606452 (1)
    inositol 1,4,5 trisphosphate 65.9 2 18450967 (1), 16314422 (1)
    phosphoinositide 63.8 7 16314422 (3), 9468531 (2), 10859228 (1)
    dpdpe 48.2 10 9614207 (7)
    fmlp 47.8 4 9556582 (3)
    calcium 37.2 10 11325525 (1), 17118346 (1), 20348095 (1), 18411281 (1) (see all 8)
    inositol 21 1 15075212 (1)
    tyrosine 7.67 1 8663010 (1)

    Search CenterWatch for drugs/clinical trials and news about PLCB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLCB3 gene (2 alternative transcripts): 
    NM_000932.2  NM_001184883.1  

    Unigene Cluster for PLCB3:

    Phospholipase C, beta 3 (phosphatidylinositol-specific)
    Hs.523761  [show with all ESTs]
    Unigene Representative Sequence: NM_000932
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279230 ENST00000540288(uc009ypi.3 uc009ypg.2 uc009yph.2)
    ENST00000325234 ENST00000536243
    miRNA
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    Additional mRNA sequence: 

    BC032659.1 BC041625.1 BC142681.1 BC146645.1 Z16411.1 Z26649.1 

    7 DOTS entries:

    DT.311011  DT.100776623  DT.92424080  DT.75102703  DT.92424078  DT.92424079  DT.91975386 

    24/92 AceView cDNA sequences (see all 92):

    BC041625 BM810177 NM_000932 BM912164 BM915329 BM810759 BM470727 BE870344 
    Z16411 BU170609 BQ923679 BM559276 BQ434725 CA446700 BM552621 BM765893 
    BM562757 BM912079 BM561351 CF125604 BM808620 BU162830 BV203085 BQ428483 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PLCB3 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                                                                                                      
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for PLCB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLCB3 expression in normal human tissues (normalized intensities)      PLCB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAAGTG
    PLCB3 Expression
    About this image


    PLCB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             ganglion/cranial   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             Ureter
             visceral organ   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   

    See PLCB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLCB3

    SOURCE GeneReport for Unigene cluster: Hs.523761
        SABiosciences Custom PCR Arrays for PLCB3
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PLCB3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcb31 , 5 phospholipase C, beta 31, 5 86.81(n)1
    92.3(a)1
      19 (5.10 cM)5
    187971  NM_008874.31  NP_032900.21 
     69537135 
    lizard
    (Anolis carolinensis)
    Reptilia PLCB36
    phospholipase C, beta 3 (phosphatidylinositol-spec...
    71(a)
    1 ↔ 1
    GL343898.1(18599-81386)
    African clawed frog
    (Xenopus laevis)
    Amphibia PLC12 phospholipase C beta type 75.49(n)    L20816.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plcb31 phospholipase C, beta 3 (phosphatidylinositol-specific) 62.48(n)
    61.57(a)
      100001532  NM_001122773.1  NP_001116245.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Plc21C3 diacylglycerol biosynthesis
    1-phosphatidylinositol-4,5-bisphosphate
    more
    47(a)     --


    ENSEMBL Gene Tree for PLCB3 (if available)
    TreeFam Gene Tree for PLCB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLCB3 gene
    PLCD42  PLCD12  PLCE12  PLCB22  PLCZ12  PLCH12  PLCD32  PLCH22  
    PLCB12  PLCB42  PLCL12  PLCL22  
    3 SIMAP similar genes for PLCB3 using alignment to 1 protein entry:     PLCB3_HUMAN:
    PLCB1    PLCB2    PLCB4

    PLCB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/970 SNPs in PLCB3 are shown (see all 970)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6335611,2
    C,F,A,H--60325220(-) ATCTCC/TGCACG 2 -- int127Minor allele frequency- T:0.06MN NS EA NA WA CSA EU 8179
    rs6335571,2
    C,F,H--60325229(-) TCTCGG/AGCAAT 2 -- int124Minor allele frequency- A:0.05NS EA NA WA CSA EU 7118
    rs783096451,2
    C,F--60326050(+) ACGCGG/AGTCTG 2 -- int11Minor allele frequency- A:0.02NA 120
    rs800581871,2
    C--60326105(+) CCTTTG/ACAGAA 2 -- int13Minor allele frequency- A:0.03NA EA 242
    rs157061,2
    C,H--60326130(-) CAGAGG/AGAAGG 2 -- int14Minor allele frequency- A:0.00MN NS NA 412
    rs1873252261,2
    --60326402(+) GCTCCC/TAGGTT 2 -- int10--------
    rs1177143041,2
    C,F--60326434(+) TCCCTG/ACTGAG 2 -- int11Minor allele frequency- A:0.02NA 120
    rs778293661,2
    C,F--60326518(+) AAACCG/CAACGC 2 -- int11Minor allele frequency- C:0.50WA 2
    rs1434477231,2
    --60326522(+) CCAACC/GCTCTT 2 -- int10--------
    rs791587951,2
    F--60326525(+) ACGCTC/TTTACC 2 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for PLCB3 (64018995 - 64036924 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PLCB3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1156n71CNV Loss21882294
    dgv1167n71CNV Loss21882294
    dgv1165n71CNV Loss21882294
    dgv1164n71CNV Loss21882294
    nsv832186CNV Loss17160897
    dgv1166n71CNV Loss21882294
    dgv1163n71CNV Loss21882294
    nsv469961CNV Loss18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600230    OMIM disorders: --

    20/21 diseases for PLCB3 (see all 21):    About MalaCards
    wermer syndrome    multiple endocrine neoplasia    trypanosomiasis    neurologic diseases
    chagas disease    hiv type 1    ichthyosis    hyperparathyroidism
    pertussis    huntington's disease    cystic fibrosis    cholera
    myocardial infarction    glioblastoma    retinitis    pancreatitis
    endotheliitis    alzheimer's disease    neuronitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for PLCB3:
    Wermer syndrome

    PLCB3 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PLCB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple endocrine neoplasia type 1 76 14 9003511 (6), 7491535 (4)
    multiple endocrine neoplasia 51.9 1 11178984 (1)
    pancreatic tumor 29.9 3 7491535 (1)
    tumors 0 1 9003511 (1)

    Genetic Association Database (GAD): PLCB3
    Human Genome Epidemiology (HuGE) Navigator: PLCB3 (6 documents)

    Export disorders for PLCB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLCB3 gene, integrated from 9 sources (see all 121):
    (articles sorted by number of sources associating them with PLCB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3). (PubMed id 7607669)1, 2, 9 Lagercrantz J.... Weber G. (1995)
    2. The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours. (PubMed id 7849701)1, 3, 9 Weber G....Teh B.T. (1994)
    3. Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene. (PubMed id 7612006)1, 2, 9 Mazuruk K.... Rodriguez I.R. (1995)
    4. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily. (PubMed id 1333955)1, 2 Carozzi A.J.... Parker P.J. (1992)
    7. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. (PubMed id 18411281)1, 9 Roach T.I....Seaman W.E. (2008)
    8. KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser. (PubMed id 11325525)1, 9 Yue C. and Sanborn B.M. (2001)
    9. Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases. (PubMed id 11278298)1, 9 Xia C....Liu M. (2001)
    10. Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13. (PubMed id 7789993)1, 9 Sinke R.J. and Geurts van Kessel A.G. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5331 HGNC: 9056 AceView: PLCB3 Ensembl:ENSG00000149782 euGenes: HUgn5331
    ECgene: PLCB3 Kegg: 5331 H-InvDB: PLCB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLCB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLCB3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLCB3 gene:
    Search GeneIP for patents involving PLCB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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