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Aliases for PLCB3 Gene

Aliases for PLCB3 Gene

  • Phospholipase C Beta 3 2 3 5
  • Phospholipase C, Beta 3 (Phosphatidylinositol-Specific) 2 3
  • Phosphoinositide Phospholipase C-Beta-3 3 4
  • EC 4 63
  • PLC-Beta-3 3 4
  • Phospholipase C-Beta-3 4
  • PLC Beta 3 3

External Ids for PLCB3 Gene

Previous GeneCards Identifiers for PLCB3 Gene

  • GC11P066534
  • GC11P065700
  • GC11P064269
  • GC11P063794
  • GC11P063775
  • GC11P064019
  • GC11P060321

Summaries for PLCB3 Gene

Entrez Gene Summary for PLCB3 Gene

  • This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for PLCB3 Gene

PLCB3 (Phospholipase C Beta 3) is a Protein Coding gene. Diseases associated with PLCB3 include Multiple Endocrine Neoplasia 1. Among its related pathways are Platelet activation and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is PLCH1.

UniProtKB/Swiss-Prot for PLCB3 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Tocris Summary for PLCB3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCB3 Gene

Genomics for PLCB3 Gene

Regulatory Elements for PLCB3 Gene

Enhancers for PLCB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLCB3 on UCSC Golden Path with GeneCards custom track

Promoters for PLCB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLCB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCB3 Gene

64,251,523 bp from pter
64,269,452 bp from pter
17,930 bases
Plus strand

Genomic View for PLCB3 Gene

Genes around PLCB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCB3 Gene

Proteins for PLCB3 Gene

  • Protein details for PLCB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
    Protein Accession:
    Secondary Accessions:
    • A5PKZ6
    • G5E960
    • Q8N1A4

    Protein attributes for PLCB3 Gene

    1234 amino acids
    Molecular mass:
    138799 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with SHANK2 (By similarity). Interacts with LPAR2.
    • Sequence=AAH32659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLCB3 Gene

    Alternative splice isoforms for PLCB3 Gene


neXtProt entry for PLCB3 Gene

Proteomics data for PLCB3 Gene at MOPED

Post-translational modifications for PLCB3 Gene

  • Ubiquitination at Lys 804
  • Modification sites at PhosphoSitePlus

Other Protein References for PLCB3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLCB3 (PLCB3)

Domains & Families for PLCB3 Gene

Gene Families for PLCB3 Gene

Suggested Antigen Peptide Sequences for PLCB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCB3: view

Function for PLCB3 Gene

Molecular function for PLCB3 Gene

GENATLAS Biochemistry:
phospholipase C,beta 3,phosphatidyl inositol specific,involved in signal transduction,excluded as a candidate in the tumorigenesis of endocrine tumor (see MEN1)
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Enzyme Numbers (IUBMB) for PLCB3 Gene

Gene Ontology (GO) - Molecular Function for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IPI 12821674
genes like me logo Genes that share ontologies with PLCB3: view
genes like me logo Genes that share phenotypes with PLCB3: view

Animal Models for PLCB3 Gene

MGI Knock Outs for PLCB3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCB3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLCB3 Gene

Localization for PLCB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCB3 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for PLCB3 Gene COMPARTMENTS Subcellular localization image for PLCB3 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 3
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for PLCB3 Gene

Pathways & Interactions for PLCB3 Gene

genes like me logo Genes that share pathways with PLCB3: view

Pathways by source for PLCB3 Gene

SIGNOR curated interactions for PLCB3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003073 regulation of systemic arterial blood pressure IDA 18468998
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission IEA,TAS --
genes like me logo Genes that share ontologies with PLCB3: view

Drugs & Compounds for PLCB3 Gene

(5) Drugs for PLCB3 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
D609 Pharma PC-PLC inhibitor, Selective PC-PLC inhibitor 0

(394) Additional Compounds for PLCB3 Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PLCB3 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
RHC 80267 Diacylglycerol lipase inhibitor 83654-05-1
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCB3: view

Transcripts for PLCB3 Gene

Unigene Clusters for PLCB3 Gene

Phospholipase C, beta 3 (phosphatidylinositol-specific):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCB3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
SP6: -
SP7: -
SP10: - - -

ExUns: 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30

Relevant External Links for PLCB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLCB3 Gene

mRNA expression in normal human tissues for PLCB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCB3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x4.4).

Protein differential expression in normal tissues from HIPED for PLCB3 Gene

This gene is overexpressed in Fetal gut (14.1) and Stomach (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLCB3 Gene

SOURCE GeneReport for Unigene cluster for PLCB3 Gene Hs.523761

genes like me logo Genes that share expression patterns with PLCB3: view

Protein tissue co-expression partners for PLCB3 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PLCB3 Gene

Orthologs for PLCB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLCB3 35
  • 89.59 (n)
  • 92.68 (a)
PLCB3 36
  • 93 (a)
(Canis familiaris)
Mammalia PLCB3 35
  • 89.24 (n)
  • 93.33 (a)
PLCB3 36
  • 94 (a)
(Mus musculus)
Mammalia Plcb3 35
  • 86.81 (n)
  • 92.3 (a)
Plcb3 16
Plcb3 36
  • 92 (a)
(Pan troglodytes)
Mammalia PLCB3 35
  • 99.32 (n)
  • 99.68 (a)
PLCB3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Plcb3 35
  • 87.03 (n)
  • 93.03 (a)
(Monodelphis domestica)
Mammalia PLCB3 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia PLCB3 36
  • 81 (a)
(Anolis carolinensis)
Reptilia PLCB3 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plcb3 35
  • 64.92 (n)
  • 69.31 (a)
Str.18841 35
African clawed frog
(Xenopus laevis)
Amphibia PLC1 35
(Danio rerio)
Actinopterygii plcb3 35
  • 62.49 (n)
  • 61.64 (a)
plcb3 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Plc21C 37
  • 47 (a)
Plc21C 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for PLCB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLCB3 Gene

Gene Tree for PLCB3 (if available)
Gene Tree for PLCB3 (if available)

Paralogs for PLCB3 Gene

Paralogs for PLCB3 Gene

(3) SIMAP similar genes for PLCB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLCB3: view

Variants for PLCB3 Gene

Sequence variations from dbSNP and Humsavar for PLCB3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12146487 - 64,259,167(+) CGGGC(A/G)CAAGC reference, missense
rs588177 -- 64,256,584(-) GCTGG(G/T)GTCCC intron-variant
rs589030 -- 64,264,326(-) CCACT(C/G)CAAGC intron-variant
rs599908 -- 64,256,280(-) GCCTG(C/G)CCCTG intron-variant
rs632439 -- 64,254,987(-) TTCAC(C/T)GGGTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PLCB3 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294