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PLCB3 Gene

protein-coding   GIFtS: 72
GCID: GC11P064019

Phospholipase C, Beta 3 (Phosphatidylinositol-Specific)

  See PLCB3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase C, Beta 3 (Phosphatidylinositol-Specific)1 2     1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-32
Phosphoinositide Phospholipase C-Beta-32 3     PLC Beta 32
PLC-beta-32 3     Phospholipase C-Beta-33
EC 3.1.4.113 8     

External Ids:    HGNC: 90561   Entrez Gene: 53312   Ensembl: ENSG000001497827   OMIM: 6002305   UniProtKB: Q019703   

Export aliases for PLCB3 gene to outside databases

Previous GC identifers: GC11P066534 GC11P065700 GC11P064269 GC11P063794 GC11P063775 GC11P060321


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLCB3 Gene:
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production
of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in
G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript
variants.(provided by RefSeq, May 2010)

GeneCards Summary for PLCB3 Gene:
PLCB3 (phospholipase C, beta 3 (phosphatidylinositol-specific)) is a protein-coding gene. Diseases associated with PLCB3 include wermer syndrome. GO annotations related to this gene include calmodulin binding and calcium ion binding. An important paralog of this gene is PLCD4.

UniProtKB/Swiss-Prot: PLCB3_HUMAN, Q01970
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
(IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes

summary for PLCB3 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLCB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLCB3 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   E2F   E2F-1   SEF-1 (1)   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCB3 promoter sequence
   Search Chromatin IP Primers for PLCB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

PLCB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCB3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064019:  view genomic region     (about GC identifiers)

Start:
64,018,995 bp from pter      End:
64,036,924 bp from pter
Size:
17,930 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLCB3_HUMAN, Q01970 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3  
Size: 1234 amino acids; 138799 Da
Cofactor: Calcium
Subunit: Interacts with SHANK2 (By similarity). Interacts with LPAR2
Sequence caution: Sequence=AAH32659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for PLCB3:
3OHM (3D)        4GNK (3D)    
Secondary accessions: A5PKZ6 G5E960 Q8N1A4
Alternative splicing: 2 isoforms:  Q01970-1   Q01970-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PLCB3: NX_Q01970

Explore proteomics data for PLCB3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys804
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PLCB3 (Q01970) (see all 24)
     RVDSSNY  EFVEYNK  KRVETAL  VALNFQT 


    See PLCB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000923.1  NP_001171812.1  

    ENSEMBL proteins: 
     ENSP00000279230   ENSP00000443631   ENSP00000324660  
    Reactome Protein details: Q01970

    PLCB3 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online antibodies for PLCB3 (80 products) 

    PLCB3 Assay Products:

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    antibodies-online kits for PLCB3 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: PLCbeta3
    Phosphoinositide-specific phospholipase C

    Selected InterPro protein domains (see all 12):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-dom_pair
     IPR001192 PI-PLC_fam
     IPR011993 PH_like_dom
     IPR016280 PLC-beta

    Graphical View of Domain Structure for InterPro Entry Q01970

    ProtoNet protein and cluster: Q01970

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C


    UniProtKB/Swiss-Prot: PLCB3_HUMAN, Q01970
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain


    Find genes that share domains with PLCB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCB3_HUMAN, Q01970
    Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
    (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
    + diacylglycerol

         Genatlas biochemistry entry for PLCB3:
    phospholipase C,beta 3,phosphatidyl inositol specific,involved in signal transduction,excluded as a candidate in
    the tumorigenesis of endocrine tumor (see MEN1)

         Enzyme Number (IUBMB): EC 3.1.4.111 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IEA--
    GO:0004629phospholipase C activity TAS7607669
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PLCB3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PLCB3:
     Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Plcb3):
     behavior/neurological  embryogenesis  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging 

    Find genes that share phenotypes with PLCB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PLCB3: Plcb3tm1Dwu Plcb3tm1Sko

       genOway: Develop your customized and physiologically relevant rodent model for PLCB3

    miRNA
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    miRTarBase miRNAs that target PLCB3:
    hsa-mir-1 (MIRT023858), hsa-let-7b-5p (MIRT032418), hsa-mir-197-3p (MIRT048057)

    Block miRNA regulation of human, mouse, rat PLCB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLCB3 (see all 25):
    hsa-miR-485-5p hsa-miR-3607-3p hsa-miR-513a-5p hsa-miR-765 hsa-miR-134 hsa-miR-575 hsa-miR-3074-3p hsa-miR-486-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLCB3

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCB3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLCB3_HUMAN, Q01970: Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--
    GO:0043234protein complex IDA18468998

    Find genes that share ontologies with PLCB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLCB3 About   (see all 80)  
    See pathways by source

    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    Activation of Kainate Receptors upon glutamate binding0.68
    G beta-gamma signalling through PLC beta0.79
    G-Protein Signaling through Tubby Protein0.35
    Presynaptic function of Kainate receptors0.76
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    2Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin 1 EDNRA transactivation of EGFR0.41
    Inflammatory mediator regulation of TRP channels0.37
    Cytoskeleton remodeling FAK signaling0.41
    Estrogen signaling pathway0.34
    3Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.36
    Phosphatidylinositol signaling system0.61
    D-myo-inositol-5-phosphate metabolism0.00
    superpathway of inositol phosphate compounds0.60
    4fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    5Ca-dependent events
    PLC beta mediated events0.67
    Opioid Signalling0.54
    G-protein mediated events0.65
    Signal transduction Calcium signaling0.35


    Find genes that share SuperPaths with PLCB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PLCB3
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLCB3 (see all 55)
        Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for PLCB3
        Ca, cAMP and Lipid Signaling

    Selected GeneGo (Thomson Reuters) Pathways for PLCB3 (see all 23)
        Anandamide biosynthesis and metabolism
    Development Endothelin-1/EDNRA transactivation of EGFR
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation

    Selected BioSystems Pathways for PLCB3 (see all 14)
        Myometrial Relaxation and Contraction Pathways
    Signal Transduction of S1P Receptor
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    MAPK Cascade

    Selected Reactome Pathways for PLCB3 (see all 8)
        Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
    Presynaptic function of Kainate receptors
    Synthesis of IP3 and IP4 in the cytosol
    Acetylcholine regulates insulin secretion
    PLC beta mediated events

    3 PharmGKB Pathways for PLCB3
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PLCB3) (see all 35):
        Inositol phosphate metabolism
    Metabolic pathways
    Rap1 signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLCB3
    Interactions:

        Search GeneGlobe Interaction Network for PLCB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLCB3 (Q019702, 3 ENSP000002792304) via UniProtKB, MINT, STRING, and/or I2D (see all 279)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3, ENSP000003639214MINT-62362 MINT-62354 MINT-62363 MINT-62358 MINT-62361 I2D: score=3 STRING: ENSP00000363921
    EZRP153112, 3, ENSP000003389344MINT-73254 I2D: score=1 STRING: ENSP00000338934
    SLC9A3R1O147452, 3, ENSP000002626134MINT-73251 I2D: score=1 STRING: ENSP00000262613
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    PARD6AQ9NPB62, 3, ENSP000002192554MINT-62359 MINT-62355 I2D: score=3 STRING: ENSP00000219255
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003073regulation of systemic arterial blood pressure IDA18468998
    GO:0006629lipid metabolic process ----
    GO:0007165signal transduction ----
    GO:0007268synaptic transmission TAS--
    GO:0016042lipid catabolic process IEA--

    Find genes that share ontologies with PLCB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for PLCB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLCB3 (see all 1226)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    8 Novoseek inferred chemical compound relationships for PLCB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pl-cs 74.6 1 11606452 (1)
    inositol 1,4,5 trisphosphate 65.9 2 18450967 (1), 16314422 (1)
    phosphoinositide 63.8 7 16314422 (3), 9468531 (2), 10859228 (1)
    dpdpe 48.2 10 9614207 (7)
    fmlp 47.8 4 9556582 (3)
    calcium 37.2 10 11325525 (1), 17118346 (1), 20348095 (1), 18411281 (1) (see all 8)
    inositol 21 1 15075212 (1)
    tyrosine 7.67 1 8663010 (1)



    Find genes that share compounds with PLCB3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLCB3 gene (2 alternative transcripts): 
    NM_000932.2  NM_001184883.1  

    Unigene Cluster for PLCB3:

    Phospholipase C, beta 3 (phosphatidylinositol-specific)
    Hs.523761  [show with all ESTs]
    Unigene Representative Sequence: NM_000932
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279230 ENST00000540288(uc009ypi.3 uc009ypg.2 uc009yph.2)
    ENST00000325234 ENST00000536243
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PLCB3 (see all 25):
    hsa-miR-485-5p hsa-miR-3607-3p hsa-miR-513a-5p hsa-miR-765 hsa-miR-134 hsa-miR-575 hsa-miR-3074-3p hsa-miR-486-3p
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      QuantiFast Probe-based Assays in human, mouse, rat PLCB3

    Additional mRNA sequence: 

    BC032659.1 BC041625.1 BC142681.1 BC146645.1 Z16411.1 Z26649.1 

    7 DOTS entries:

    DT.311011  DT.100776623  DT.92424080  DT.75102703  DT.92424078  DT.92424079  DT.91975386 

    Selected AceView cDNA sequences (see all 92):

    BE870344 BM912164 BM552621 BM915329 BM559276 BC041625 BM765893 BQ434725 
    CA446700 BM810759 Z16411 CF125604 BQ923679 BM562757 BM470727 NM_000932 
    BM810177 BM912079 BU170609 BM808620 BM561351 BG327142 BC032659 BM913217 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLCB3 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                                                                                                      
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for PLCB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PLCB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAAGTG
    PLCB3 Expression
    About this image


    PLCB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Kidney (Urinary System)
             Metanephros
    PLCB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLCB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523761
        Custom PCR Arrays for PLCB3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLCB3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcb31 , 5 phospholipase C, beta 31, 5 86.81(n)1
    92.3(a)1
      19 (5.10 cM)5
    187971  NM_008874.31  NP_032900.21 
     69537135 
    lizard
    (Anolis carolinensis)
    Reptilia PLCB36
    phospholipase C, beta 3 (phosphatidylinositol-spec...
    72(a)
    1 ↔ 1
    GL343898.1(18599-81386)
    African clawed frog
    (Xenopus laevis)
    Amphibia PLC12 phospholipase C beta type 75.49(n)    L20816.1 
    zebrafish
    (Danio rerio)
    Actinopterygii plcb31 phospholipase C, beta 3 (phosphatidylinositol-specific) 62.49(n)
    61.64(a)
      100001532  NM_001122773.1  NP_001116245.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Plc21C3 diacylglycerol biosynthesis
    1-phosphatidylinositol-4,5-bisphosphate
    more
    47(a)     --


    ENSEMBL Gene Tree for PLCB3 (if available)
    TreeFam Gene Tree for PLCB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLCB3 gene
    PLCD42  PLCD12  PLCB22  PLCZ12  PLCH12  PLCD32  PLCH22  PLCB12  
    PLCB42  PLCL22  PLCL12  
    3 SIMAP similar genes for PLCB3 using alignment to 1 protein entry:     PLCB3_HUMAN:
    PLCB1    PLCB2    PLCB4

    Find genes that share paralogs with PLCB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLCB3 (see all 970)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6335611,2
    C,F,A,H--60325220(-) ATCTCC/TGCACG 2 -- int127Minor allele frequency- T:0.06MN NS EA NA WA CSA EU 8179
    rs6335571,2
    C,F,H--60325229(-) TCTCGG/AGCAAT 2 -- int124Minor allele frequency- A:0.05NS EA NA WA CSA EU 7118
    rs783096451,2
    C,F--60326050(+) ACGCGG/AGTCTG 2 -- int11Minor allele frequency- A:0.02NA 120
    rs800581871,2
    C--60326105(+) CCTTTG/ACAGAA 2 -- int13Minor allele frequency- A:0.03NA EA 242
    rs157061,2
    C,H--60326130(-) CAGAGG/AGAAGG 2 -- int14Minor allele frequency- A:0.00MN NS NA 412
    rs1873252261,2
    --60326402(+) GCTCCC/TAGGTT 2 -- int10--------
    rs1177143041,2
    C,F--60326434(+) TCCCTG/ACTGAG 2 -- int11Minor allele frequency- A:0.02NA 120
    rs778293661,2
    C,F--60326518(+) AAACCG/CAACGC 2 -- int11Minor allele frequency- C:0.50WA 2
    rs1434477231,2
    --60326522(+) CCAACC/GCTCTT 2 -- int10--------
    rs791587951,2
    F--60326525(+) ACGCTC/TTTACC 2 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for PLCB3 (64018995 - 64036924 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PLCB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1156n71CNV Loss21882294
    dgv1167n71CNV Loss21882294
    dgv1165n71CNV Loss21882294
    dgv1164n71CNV Loss21882294
    nsv832186CNV Loss17160897
    dgv1166n71CNV Loss21882294
    dgv1163n71CNV Loss21882294
    nsv469961CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600230    OMIM disorders: --

    1 disease for PLCB3:    
    About MalaCards
    wermer syndrome

    1 disease from the University of Copenhagen DISEASES database for PLCB3:
    Wermer syndrome

    Find genes that share disorders with PLCB3           About GenesLikeMe

    4 Novoseek inferred disease relationships for PLCB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple endocrine neoplasia type 1 76 14 9003511 (6), 7491535 (4)
    multiple endocrine neoplasia 51.9 1 11178984 (1)
    pancreatic tumor 29.9 3 7491535 (1)
    tumors 0 1 9003511 (1)

    Genetic Association Database (GAD): PLCB3
    Human Genome Epidemiology (HuGE) Navigator: PLCB3 (6 documents)

    Export disorders for PLCB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLCB3 gene, integrated from 10 sources (see all 121):
    (articles sorted by number of sources associating them with PLCB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3). (PubMed id 7607669)1, 2, 9 Lagercrantz J.... Weber G. (Genomics 1995)
    2. The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours. (PubMed id 7849701)1, 3, 9 Weber G....Teh B.T. (Hum. Mol. Genet. 1994)
    3. Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene. (PubMed id 7612006)1, 2, 9 Mazuruk K.... Rodriguez I.R. (Biochem. Biophys. Res. Commun. 1995)
    4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily. (PubMed id 1333955)1, 2 Carozzi A.J.... Parker P.J. (Eur. J. Biochem. 1992)
    7. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. (PubMed id 18411281)1, 9 Roach T.I....Seaman W.E. (J. Biol. Chem. 2008)
    8. KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser. (PubMed id 11325525)1, 9 Yue C. and Sanborn B.M. (Mol. Cell. Endocrinol. 2001)
    9. Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases. (PubMed id 11278298)1, 9 Xia C....Liu M. (J. Biol. Chem. 2001)
    10. Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13. (PubMed id 7789993)1, 9 Sinke R.J. and Geurts van Kessel A.G. (Genomics 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5331 HGNC: 9056 AceView: PLCB3 Ensembl:ENSG00000149782 euGenes: HUgn5331
    ECgene: PLCB3 Kegg: 5331 H-InvDB: PLCB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLCB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLCB3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLCB3 gene:
    Search GeneIP for patents involving PLCB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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