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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLCB2 Gene

protein-coding   GIFtS: 70
GCID: GC15M040580

Phospholipase C, Beta 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase C, Beta 21 2
Phosphoinositide Phospholipase C-Beta-22 3
PLC-beta-22 3
EC 3.1.4.113 8
1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-22
Phospholipase C-Beta-23

External Ids:    HGNC: 90551   Entrez Gene: 53302   Ensembl: ENSG000001378417   OMIM: 6041145   UniProtKB: Q007223   

Export aliases for PLCB2 gene to outside databases

Previous GC identifers: GC15M035947 GC15M033475 GC15M038159 GC15M038296 GC15M038367 GC15M017423


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PLCB2 Gene: 
PLCB2 (phospholipase C, beta 2) is a protein-coding gene. Diseases associated with PLCB2 include prostate leiomyosarcoma, and balanitis, and among its related super-pathways are fMLP Pathway and Prostacyclin signalling through prostacyclin receptor. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and calcium ion binding. An important paralog of this gene is PLCD4.

UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
(IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes

summary for PLCB2 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLCB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLCB2 gene promoter:
         ER-alpha   Tal-1   p53   Nkx2-5   E47   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLCB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLCB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.1

PLCB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCB2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M040580:  view genomic region     (about GC identifiers)

Start:
40,570,377 bp from pter      End:
40,600,174 bp from pter
Size:
29,798 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2  
Size: 1185 amino acids; 134024 Da
Cofactor: Binds 1 calcium ion per subunit
Subunit: Interacts with RAC1
Miscellaneous: The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha
subunit, alpha-16
2 PDB 3D structures from and Proteopedia for PLCB2:
2FJU (3D)        2ZKM (3D)    
Secondary accessions: A8K6J2
Alternative splicing: 2 isoforms:  Q00722-1   Q00722-2   

Explore the universe of human proteins at neXtProt for PLCB2: NX_Q00722

Explore proteomics data for PLCB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q00722

  • 4/14 DME Specific Peptides for PLCB2 (Q00722) (see all 14)
     VALNFQT  PLNHYFI  ISGQFLS  SSHNTYL 

    PLCB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLCB2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001271226.1  NP_001271227.1  NP_001271228.1  NP_004564.2  

    ENSEMBL proteins: 
     ENSP00000452916   ENSP00000260402   ENSP00000454025   ENSP00000452642   ENSP00000453975  
     ENSP00000411991   ENSP00000444652  
    Reactome Protein details: Q00722
    Human Recombinant Protein Products for PLCB2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PLCB2
    GenScript Custom Purified and Recombinant Proteins Services for PLCB2
    Novus Biologicals PLCB2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0044444cytoplasmic part ----

    PLCB2 for ontologies           About GeneDecksing



    PLCB2 Antibody Products: 
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    Novus Biologicals PLCB2 Antibody
    Abcam antibodies for PLCB2
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    LSBio Antibodies in human, mouse, rat for PLCB2 

    Assay Products for PLCB2: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: PLCβ2 
    Phosphoinositide-specific phospholipase C

    5/11 InterPro protein domains (see all 11):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-like_dom
     IPR001192 Pinositol_PLipase_C
     IPR018029 C2_membr_targeting
     IPR016280 PLC-beta

    Graphical View of Domain Structure for InterPro Entry Q00722

    ProtoNet protein and cluster: Q00722

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C


    UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain


    PLCB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCB2_HUMAN, Q00722
    Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
    (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
    + diacylglycerol

         Genatlas biochemistry entry for PLCB2:
    phospholipase C,beta 2,predominantly expressed in hematopoietic cells,critical to many chemoattractant elicited
    responses,involved in signal transduction

         Enzyme Number (IUBMB): EC 3.1.4.111 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IEA--
    GO:0004629phospholipase C activity TAS7649993
    GO:0004871signal transducer activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    PLCB2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PLCB2:
     Increased cilium length after  

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plcb2):
     hematopoietic system  homeostasis/metabolism  immune system  integument  taste/olfaction 

    PLCB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Plcb2tm1Dwu for PLCB2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLCB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLCB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLCB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLCB2 

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCB2:
    hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3065-5p hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidPLCB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLCB2
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    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of PLCB2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PLCB2 (see all 5)
    OriGene ORF clones in mouse, rat for PLCB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLCB2 (NM_004573)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCB2
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                         Customized lentivirus expression plasmids for stable overexpression of PLCB2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLCB2 About   (see all 82)                                                                                              See pathways by source

    SuperPathContained pathways About
    1fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    Huntington's Disease Pathway0.30
    2Prostacyclin signalling through prostacyclin receptor
    G-protein beta:gamma signalling0.89
    Activation of Kainate Receptors upon glutamate binding0.70
    G beta:gamma signalling through PLC beta0.77
    G-Protein Signaling through Tubby Protein0.38
    Presynaptic function of Kainate receptors0.74
    3Ca-dependent events
    PLC beta mediated events0.65
    Opioid Signalling0.55
    G-protein mediated events0.64
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    4Anandamide biosynthesis and metabolism
    D-myo-inositol-5-phosphate metabolism0.50
    Anandamide biosynthesis and metabolism0.34
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.50
    phospholipases0.34
    5Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA transactivation of EGFR0.41
    GnRH signaling pathway0.38
    Cytoskeleton remodeling FAK signaling0.41
    Estrogen signaling pathway0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/23 EMD Millipore Pathways for PLCB2 (see all 23)
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Transcription Transcription factor Tubby signaling pathways
    Cytoskeleton remodeling FAK signaling
    Signal transduction IP3 signaling
    Immune response CCR3 signaling in eosinophils

    1 R&D Systems Pathway for PLCB2
        Wnt Signaling Pathway

    5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLCB2 (see all 56)
        Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    Aldosterone Signaling in Epithelial Cells

    5/25 GeneGo (Thomson Reuters) Pathways for PLCB2 (see all 25)
        Anandamide biosynthesis and metabolism
    Development Endothelin-1/EDNRA transactivation of EGFR
    G-protein signaling Rac2 regulation pathway
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Development Angiotensin signaling via PYK2

    5/14 BioSystems Pathways for PLCB2 (see all 14)
        MicroRNAs in cardiomyocyte hypertrophy
    Signal Transduction of S1P Receptor
    D-myo-inositol-5-phosphate metabolism
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis
    Alzheimers Disease

    5/23        Reactome Pathways for PLCB2 (see all 23)
        Activation of Kainate Receptors upon glutamate binding
    Transmission across Chemical Synapses
    Metabolism
    Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
    Regulation of Insulin Secretion

    3 PharmGKB Pathways for PLCB2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/32         Kegg Pathways  (Kegg details for PLCB2) (see all 32):
        Inositol phosphate metabolism
    Metabolic pathways
    Calcium signaling pathway
    Chemokine signaling pathway
    Phosphatidylinositol signaling system


    PLCB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLCB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/254 Interacting proteins for PLCB2 (Q007222, 3 ENSP000002604024) via UniProtKB, MINT, STRING, and/or I2D (see all 254)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAQP501483, ENSP000002865484I2D: score=2 STRING: ENSP00000286548
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    TRPC3Q135073, ENSP000003689664I2D: score=1 STRING: ENSP00000368966
    MAP2K3P467343, ENSP000003450834I2D: score=2 STRING: ENSP00000345083
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006644phospholipid metabolic process TAS1644792
    GO:0007165signal transduction ----
    GO:0007202activation of phospholipase C activity TAS7649993
    GO:0007268synaptic transmission TAS--

    PLCB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLCB2 for compounds           About GeneDecksing

    EMD Millipore small molecules for PLCB2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PLCB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    10/1226 HMDB Compounds for PLCB2 (see all 1226)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    8 Novoseek inferred chemical compound relationships for PLCB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanosine 5'-o-(3-thiotriphosphate) 44.1 3 9799233 (2)
    phosphatidylinositol 40.8 3 9020783 (1), 12761218 (1), 8132501 (1)
    leukotriene b4 40.1 1 11806993 (1)
    fmlp 29.7 1 11806993 (1)
    phosphoinositide 18.9 2 17478077 (2)
    calcium 18.4 4 8223634 (1), 11806993 (1)
    phospholipid 13.4 4 9020783 (1), 8223634 (1)
    retinoic acid 4.86 10 16408290 (3), 17478077 (1)

    Search CenterWatch for drugs/clinical trials and news about PLCB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLCB2 gene (4 alternative transcripts): 
    NM_001284297.1  NM_001284298.1  NM_001284299.1  NM_004573.2  

    Unigene Cluster for PLCB2:

    Phospholipase C, beta 2
    Hs.355888  [show with all ESTs]
    Unigene Representative Sequence: NM_004573
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560009 ENST00000559671 ENST00000260402(uc001zld.3 uc010bbo.3 uc010ucm.2)
    ENST00000559381(uc001zlc.3) ENST00000559618 ENST00000558588 ENST00000557821
    ENST00000456256 ENST00000558505 ENST00000560701 ENST00000561378 ENST00000558409
    ENST00000560093 ENST00000543785(uc001zle.4) ENST00000559634
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCB2:
    hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3065-5p hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidPLCB2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLCB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCB2
    Clone
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    OriGene clones in human, mouse for PLCB2 (see all 5)
    OriGene ORF clones in mouse, rat for PLCB2
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    GenScript: all cDNA clones in your preferred vector: PLCB2 (NM_004573)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCB2
    Sirion Biotech Customized lentivirus for stable overexpression of PLCB2 
                         Customized lentivirus expression plasmids for stable overexpression of PLCB2 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCB2

    Additional mRNA sequence: 

    AB209583.1 AK095454.1 AK130831.1 AK291657.1 BC000939.3 BC009009.1 BC136467.1 BT006905.1 
    M95678.1 

    13 DOTS entries:

    DT.112491  DT.86857819  DT.121039156  DT.91717568  DT.95215191  DT.95278919  DT.95169486  DT.100775471 
    DT.121039181  DT.455229  DT.86839669  DT.91956934  DT.91717581 

    24/125 AceView cDNA sequences (see all 125):

    AW294690 CD369500 F04675 AI655426 CR601877 AA310466 AW630959 AW402206 
    CB126410 BC009009 T89023 F12578 BF902936 BM667278 AK130831 BX099469 
    T28538 CF136301 CA438632 BE540889 BF899548 BI910963 BP368174 BG258587 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for PLCB2 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^
    SP1:                                                                                                  -                       -     -     -     -     -     -   
    SP2:                    -                                                                                                                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b
    SP1:  -     -     -     -     -     -     -     -     -     -     -     -                                         -                     
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for PLCB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLCB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCCCTCTC
    PLCB2 Expression
    About this image


    See PLCB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLCB2

    SOURCE GeneReport for Unigene cluster: Hs.355888
        SABiosciences Expression via Pathway-Focused PCR Array including PLCB2: 
              Gap Junctions in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PLCB2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcb21 , 5 phospholipase C, beta 21, 5 85.72(n)1
    86.51(a)1
      2 (59.43 cM)5
    187961  NM_177568.21  NP_808236.21 
     1187075175 
    chicken
    (Gallus gallus)
    Aves PLCB21 phospholipase C, beta 2 72(n)
    72.47(a)
      423014  XM_420945.3  XP_420945.3 
    lizard
    (Anolis carolinensis)
    Reptilia PLCB26
    phospholipase C, beta 2
    69(a)
    1 ↔ 1
    GL343264.1(1295155-1364273)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.113852 Transcribed sequence with weak similarity to protein more 73.38(n)    BG305203.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Plc21C6
    Phospholipase C at 21C
    32(a)
    1 → many
    2L(305935-347927)


    ENSEMBL Gene Tree for PLCB2 (if available)
    TreeFam Gene Tree for PLCB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLCB2 gene
    PLCD42  PLCD12  PLCE12  PLCZ12  PLCH12  PLCB32  PLCD32  PLCH22  
    PLCB12  PLCB42  PLCL12  PLCL22  
    8 SIMAP similar genes for PLCB2 using alignment to 6 protein entries:     PLCB2_HUMAN (see all proteins):
    PLCB1    PLCB3    PLCB4    PLCD3    PLCZ1    DKFZp686K101
    PLCD1    PLCD4

    PLCB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/646 SNPs in PLCB2 are shown (see all 646)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846187321,2
    --40579797(+) TAAAAC/TAGGGG 1 -- int10--------
    rs1438124211,2
    C--40579818(+) ACTCAA/GCTCTT 1 -- int10--------
    rs1897935301,2
    --40580042(+) TCATTG/TCAGGG 1 -- int10--------
    rs1479929021,2
    --40580356(+) CCTCCC/TGTTCC 1 -- ut310--------
    rs1416299671,2
    C--40580448(+) TCAAGA/GAGTGG 1 -- ut310--------
    rs733913721,2
    C,F--40580476(+) CAGGCC/GTGATG 1 -- ut312Minor allele frequency- G:0.06WA 120
    rs1459260381,2
    C--40580524(+) AGTGGA/GGGTGA 1 -- ut310--------
    rs412776761,2
    C,F--40580654(+) AATATA/GTGACA 1 -- ut311Minor allele frequency- G:0.05NA 120
    rs1386020441,2
    --40580667(+) TATCTA/GGAGAT 1 -- ut310--------
    rs1818451581,2
    --40580738(+) GAGGGA/TGCCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PLCB2 (40570377 - 40600174 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for PLCB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv22666CNV Loss19812545
    nsv904098CNV Loss21882294
    nsv904095CNV Loss21882294
    dgv2359n71CNV Loss21882294
    nsv510660CNV Loss20534489
    nsv457118CNV Loss19166990
    esv34145CNV Loss18971310
    nsv517541CNV Loss19592680
    nsv471240CNV Loss18288195
    nsv827305CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604114    OMIM disorders: --

    20/22 diseases for PLCB2 (see all 22):    About MalaCards
    prostate leiomyosarcoma    balanitis    leiomyosarcoma    neurologic diseases
    trypanosomiasis    chagas disease    endocarditis    narcolepsy
    pertussis    huntington's disease    cholera    osteosarcoma
    glioblastoma    retinitis    sarcoma    alzheimer's disease
    breast cancer    prostatitis    endotheliitis    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for PLCB2:
    Prostate leiomyosarcoma

    PLCB2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PLCB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 16525635 (1)

    Genetic Association Database (GAD): PLCB2
    Human Genome Epidemiology (HuGE) Navigator: PLCB2 (9 documents)

    Export disorders for PLCB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLCB2 gene, integrated from 9 sources (see all 111):
    (articles sorted by number of sources associating them with PLCB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2. (PubMed id 1644792)1, 2, 3 Park D.... Rhee S.G. (1992)
    2. Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. (PubMed id 15274049)1, 4, 9 Morris D.W....O'Donovan M.C. (2004)
    3. Genome-wide association study identifies five new schi zophrenia loci. (PubMed id 21926974)1, 4 (2011)
    4. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization. (PubMed id 9925923)1, 3 Park S.H....Kim H. (1998)
    9. PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays. (PubMed id 16525635)1, 9 Bertagnolo V....Capitani S. (2006)
    10. Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2. (PubMed id 15611108)1, 9 Bonacci T.M....Smrcka A.V. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5330 HGNC: 9055 AceView: PLCB2 Ensembl:ENSG00000137841 euGenes: HUgn5330
    ECgene: PLCB2 Kegg: 5330 H-InvDB: PLCB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLCB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLCB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLCB2 gene:
    Search GeneIP for patents involving PLCB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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