Aliases for PLCB2 Gene
External Ids for PLCB2 Gene
Previous GeneCards Identifiers for PLCB2 Gene
GeneCards Summary for PLCB2 Gene
PLCB2 (Phospholipase C, Beta 2) is a Protein Coding gene. Diseases associated with PLCB2 include prostate leiomyosarcoma. Among its related pathways are GPCR Pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding and phosphatidylinositol phospholipase C activity. An important paralog of this gene is PLCH1.
UniProtKB/Swiss-Prot for PLCB2 Gene
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.