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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLCB2 Gene

protein-coding GIFtS: 68
GCID: GC15M040580

phospholipase C, beta 2

Explore 21 diseases affiliated with
PLCB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase C, Beta 2¹ ²		EC 3.1.4.11³ ⁸
Phosphoinositide Phospholipase C-Beta-2² ³		FLJ38135¹
Phospholipase C-Beta-2² ³		1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-2²
PLC-Beta-2¹		1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta-2²

External Ids:	HGNC: 9055¹	Entrez Gene: 5330²	Ensembl: ENSG00000137841⁷	OMIM: 604114⁵	UniProtKB: Q00722³

Export aliases for PLCB2 gene to outside databases

Previous GC identifers: GC15M035947 GC15M033475 GC15M038159 GC15M038296 GC15M038367 GC15M017423

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

is mediated by activated phosphatidylinositol-specific phospholipase C enzymes

summary for PLCB2:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the

hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and

1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily

activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth

factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological

functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane

phospholipids.

Gene Wiki entry for PLCB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLCB2 gene promoter:
ER-alpha Tal-1 p53 Nkx2-5 E47 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLCB2 promoter sequence

Search SABiosciences Chromatin IP Primers for PLCB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLCB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q15.1

PLCB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCB2 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M040580: view genomic region (about GC identifiers)

Start:	40,570,377 bp from pter	End:	40,600,174 bp from pter
Size:	29,798 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722 (See protein sequence)

Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Size: 1185 amino acids; 134024 Da

Cofactor: Binds 1 calcium ion per subunit

Subunit: Interacts with RAC1

Miscellaneous: The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha

subunit, alpha-16

2 PDB 3D structures from and Proteopedia for PLCB2:

2FJU (3D)

2ZKM (3D)

Secondary accessions: A8K6J2

Alternative splicing: 2 isoforms: Q00722-1 Q00722-2

Explore the universe of human proteins at neXtProt for PLCB2: NX_Q00722

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q00722

4/14 DME Specific Peptides for PLCB2 (Q00722) (see all 14)

VALNFQT

PLNHYFI

ISGQFLS

SSHNTYL

PLCB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004564.2

ENSEMBL proteins:

ENSP00000452916 ENSP00000260402 ENSP00000454025 ENSP00000452642 ENSP00000453975

ENSP00000411991 ENSP00000444652

Reactome Protein details: Q00722
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for PLCB2
	Novus Biologicals PLCB2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005794	Golgi apparatus	--	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	--	--
GO:0031680	G-protein beta/gamma-subunit complex	--	--

PLCB2 for ontologies About GeneDecksing

PLCB2 Antibody Products:

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	Novus Biologicals PLCB2 Antibody
	Search for Antibodies for PLCB2 at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibody for PLCB2

Assay Products for PLCB2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PLCB2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLCB2 for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR015359 PLipase_C_EF-hand-like

IPR011992 EF-hand-like_dom

IPR001192 Pinositol_PLipase_C

IPR018029 C2_membr_targeting

IPR016280 PLC-beta

Graphical View of Domain Structure for InterPro Entry Q00722

ProtoNet protein and cluster: Q00722

2 Blocks protein families:

IPB000008 C2 domain

IPB000909 Phosphatidylinositol-specific phospholipase C

UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722

Similarity: Contains 1 C2 domain

Similarity: Contains 1 PI-PLC X-box domain

Similarity: Contains 1 PI-PLC Y-box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

is mediated by activated phosphatidylinositol-specific phospholipase C enzymes

Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate +

diacylglycerol

Genatlas biochemistry entry for PLCB2:

phospholipase C,beta 2,predominantly expressed in hematopoietic cells,critical to many chemoattractant elicited

responses,involved in signal transduction

Enzyme Number (IUBMB): EC 3.1.4.11¹ ²

miRNA Products:		OriGene 3'-UTR Clone: PLCB2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCB2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCB2:
		hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3065-5p hsa-miR-628-5p
		SwitchGear 3'UTR luciferase reporter plasmid: PLCB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLCB2 (see all 7) OriGene shRNA RFP: PLCB2 OriGene siRNA: PLCB2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCB2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PLCB2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLCB2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLCB2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLCB2 (NM_004573)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCB2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCB2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PLCB2
		Search LifeMap BioReagents cell lines for PLCB2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCB2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphatidylinositol phospholipase C activity	IEA	--
GO:0004629	phospholipase C activity	TAS	7649993
GO:0004871	signal transducer activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005543	phospholipid binding	--	--

PLCB2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PLCB2:

Increased cilium length after

Animal Models:
Mouse knock-out Plcb2^tm1Dwu for PLCB2
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Plcb2):

hematopoietic system

homeostasis/metabolism

immune system

integument

taste/olfaction

PLCB2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/85 super-pathways (see all 85) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development Angiotensin activation of ERK

8/9 pathways (see all 9)
Development Angiotensin activation of ERK	1.00	Development G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_Angiotensin activation of ERK	0.98	Development_EDNRB signaling	0.54
Development_ACM2 and ACM4 activation of ERK	0.74	Development EDNRB signaling	0.54
Development ACM2 and ACM4 activation of ERK	0.74	Cholinergic synapse	0.30

G beta:gamma signalling through PLC beta

G beta:gamma signalling through PLC beta	1.00	G-Protein Signaling through Tubby Protein	0.38
Presynaptic function of Kainate receptors	0.95	Transcription_Transcription factor Tubby signaling pathways	0.07
G-protein beta:gamma signalling	0.71	Transcription Transcription factor Tubby signaling pathways	0.07
Activation of Kainate Receptors upon glutamate binding	0.67

Opioid Signalling

Opioid Signalling	1.00	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics	0.35
G-protein mediated events	0.55	Glutamatergic synapse	0.31
PLC beta mediated events	0.54

Sweet Taste Signaling

Sweet Taste Signaling	1.00	Bitter Taste Signaling	0.44
Melatonin Signaling	0.72	Sperm Motility	0.36
Cellular Effects of Sildenafil	0.46

Development_A3 receptor signaling

	Development A3 receptor signaling	1.00			G-protein signaling_G-Protein alpha-q signaling cascades	0.53
	Development_A3 receptor signaling	1.00			G-protein signaling G-Protein alpha-q signaling cascades	0.53

Pathway sources
See GeneCards unified pathways
Show all pathways

5/23 EMD Millipore Pathways for PLCB2 (see all 23)

	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
	Transcription Transcription factor Tubby signaling pathways
	Cytoskeleton remodeling FAK signaling
	Signal transduction IP3 signaling
	Immune response CCR3 signaling in eosinophils

1 R&D Systems Pathway for PLCB2

Wnt Signaling Pathway

5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLCB2 (see all 56)

	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Intracellular Calcium Signaling
	Visual Cycle in Retinal Rods
	Aldosterone Signaling in Epithelial Cells

5/25 GeneGo (Thomson Reuters) Pathways for PLCB2 (see all 25)

	Anandamide biosynthesis and metabolism
	Development Endothelin-1/EDNRA transactivation of EGFR
	G-protein signaling Rac2 regulation pathway
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	Development Angiotensin signaling via PYK2

5/14 BioSystems Pathways for PLCB2 (see all 14)

	Signal Transduction of S1P Receptor
	MicroRNAs in cardiomyocyte hypertrophy
	D-myo-inositol (1,4,5)-trisphosphate biosynthesis
	D-myo-inositol-5-phosphate metabolism
	Alzheimers Disease

5/23 Reactome Pathways for PLCB2 (see all 23)

	Activation of Kainate Receptors upon glutamate binding
	Transmission across Chemical Synapses
	Metabolism
	Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
	Regulation of Insulin Secretion

3 PharmGKB Pathways for PLCB2

	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
	Proton Pump Inhibitor Pathway, Pharmacodynamics
	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

5/25 Kegg Pathways (Kegg details for PLCB2) (see all 25):

	Inositol phosphate metabolism
	Metabolic pathways
	Calcium signaling pathway
	Chemokine signaling pathway
	Phosphatidylinositol signaling system

PLCB2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PLCB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/254 Interacting proteins for PLCB2 (Q00722^{2, 3} ENSP00000260402⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 254)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAQ	P50148³, ENSP00000286548⁴	I2D: score=2 STRING: ENSP00000286548
SLC9A3R1	O14745³, ENSP00000262613⁴	I2D: score=2 STRING: ENSP00000262613
ALK	Q9UM73³, ENSP00000373700⁴	I2D: score=1 STRING: ENSP00000373700
TRPC3	Q13507³, ENSP00000368966⁴	I2D: score=1 STRING: ENSP00000368966
MAP2K3	P46734³, ENSP00000345083⁴	I2D: score=2 STRING: ENSP00000345083

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	--	--
GO:0006629	lipid metabolic process	--	--
GO:0006644	phospholipid metabolic process	TAS	1644792
GO:0007202	activation of phospholipase C activity	TAS	7649993
GO:0007268	synaptic transmission	TAS	--

PLCB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PLCB2 for compounds About GeneDecksing

EMD Millipore small molecules for PLCB2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLCB2 available from Tocris Bioscience About this table

Compound	Action	CAS #
m-3M3FBS	Phospholipase C activator	[200933-14-8]
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
U 73122	Phospholipase C inhibitor	[112648-68-7]
D609	Selective PC-PLC inhibitor	[83373-60-8]

10/1226 HMDB Compounds for PLCB2 (see all 1226) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
1-Phosphatidyl-D-myo-inositol	1-Phosphatidyl-1D-myo-inositol (see all 6)	--	--
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--

8 Novoseek chemical compound relationships for PLCB2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
guanosine 5'-o-(3-thiotriphosphate)	44.1	3	9799233 (2)
phosphatidylinositol	40.8	3	9020783 (1), 12761218 (1), 8132501 (1)
leukotriene b4	40.1	1	11806993 (1)
fmlp	29.7	1	11806993 (1)
phosphoinositide	18.9	2	17478077 (2)
calcium	18.4	4	8223634 (1), 11806993 (1)
phospholipid	13.4	4	9020783 (1), 8223634 (1)
retinoic acid	4.86	10	16408290 (3), 17478077 (1)

Search CenterWatch for drugs/clinical trials and news about PLCB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLCB2 gene:

NM_004573.2

Unigene Cluster for PLCB2:

Phospholipase C, beta 2

Hs.355888 [show with all ESTs]

Unigene Representative Sequence: NM_004573

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000560009 ENST00000559671 ENST00000260402(uc001zld.3 uc010bbo.3 uc010ucm.2)

ENST00000559381(uc001zlc.3) ENST00000559618 ENST00000558588 ENST00000557821

ENST00000456256 ENST00000558505 ENST00000560701 ENST00000561378 ENST00000558409

ENST00000560093 ENST00000543785(uc001zle.4) ENST00000559634

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLCB2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate PLCB2:
		hsa-miR-7-1* hsa-miR-7-2* hsa-miR-3065-5p hsa-miR-628-5p
		SwitchGear 3'UTR luciferase reporter plasmid: PLCB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLCB2 (see all 7) OriGene shRNA RFP: PLCB2 OriGene siRNA: PLCB2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLCB2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLCB2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLCB2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PLCB2 (NM_004573)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLCB2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCB2

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PLCB2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLCB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLCB2

Additional cDNA sequence:

AB209583.1 AK095454.1 AK130831.1 AK291657.1 BC000939.3 BC009009.1 BC136467.1 BT006905.1

M95678.1

13 DOTS entries:

DT.112491 DT.86857819 DT.121039156 DT.91717568 DT.95215191 DT.95278919 DT.95169486 DT.100775471

DT.121039181 DT.455229 DT.86839669 DT.91956934 DT.91717581

24/125 AceView cDNA sequences (see all 125):

F04675 AA310466 CF136301 T89023 BX099469 AW630959 AK130831 BM667278

BC009009 BF902936 AW402206 CB126410 AW294690 F12578 T28538 AI655426

CR601877 CD369500 AI982938 BE540889 AW408049 BE536627 BU728127 BF896493

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for PLCB2 (see all 15) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19a	·	19b	^
SP1:																																	-								-		-		-		-		-		-
SP2:							-
SP3:
SP4:
SP5:

ExUns:	20a	·	20b	^	21	^	22a	·	22b	^	23	^	24	^	25a	·	25b	·	25c	·	25d	^	26a	·	26b	·	26c	^	27	^	28	^	29	^	30a	·	30b	^	31	^	32a	·	32b
SP1:	-		-		-		-		-		-		-		-		-		-		-		-														-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PLCB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLCB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCCCTCTC

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PLCB2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PLCB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLCB2

SOURCE GeneReport for Unigene cluster: Hs.355888

SABiosciences Expression via Pathway-Focused PCR Array including PLCB2:

Gap Junctions in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCB2 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLCB2¹	phospholipase C, beta 2	72(n) 72.47(a)		423014 XM_420945.3 XP_420945.3
lizard (Anolis carolinensis)	Reptilia	PLCB2⁶	--	70(a)	1 ↔ 1	GL343264.1(1295531-1363849)
zebrafish (Danio rerio)	Actinopterygii	Dr.11385²	Transcribed sequence with weak similarity to protein more	73.38(n)		BG305203.1
fruit fly (Drosophila melanogaster)	Insecta	Plc21C⁶	Phospholipase C at 21C	32(a)	1 → many	2L(305935-347927)
worm (Caenorhabditis elegans)	Secernentea	Y75B12B.6³	Phosphatidylinositol-specific phospholipase C, more	30(a)		V(15195318-15200165) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ATPLC1⁶ PLC5⁶ (see all 9)	phosphoinositide phospholipase C 5 (see all 9)	24(a) 24(a) (see all 9)	many ↔ many many ↔ many (see all 9)	4(18020674-18022985) 5(23709529-23712131)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	phospholipase C, putative, expressed (see all 4)	26(a) 23(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(10024184-10026867) 12(23015165-23019784)

ENSEMBL Gene Tree for PLCB2 (if available)
TreeFam Gene Tree for PLCB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PLCB2 gene

PLCG2² PLCD4² PLCD1² PLCG1² PLCZ1² PLCH1² PLCB3² PLCD3²

PLCB1² PLCB4² PLCH2² PLCL1² PLCL2²

8 SIMAP similar genes for PLCB2 using alignment to 6 protein entries: PLCB2_HUMAN (see all proteins):

PLCB1 PLCB3 PLCB4 PLCD3 PLCZ1 DKFZp686K101

PLCD1 PLCD4

PLCB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184618732^1,2		--	40579797(+)	`TAAAAC/TAGGGG`	1	--	int¹		0	--	--	--	--
rs143812421^1,2		--	40579818(+)	`ACTCAA/GCTCTT`	1	--	int¹		0	--	--	--	--
rs189793530^1,2		--	40580042(+)	`TCATTG/TCAGGG`	1	--	int¹		0	--	--	--	--
rs147992902^1,2		--	40580356(+)	`CCTCCC/TGTTCC`	1	--	ut3¹		0	--	--	--	--
rs141629967^1,2		--	40580448(+)	`TCAAGA/GAGTGG`	1	--	ut3¹		0	--	--	--	--
rs73391372^1,2	C,	--	40580476(+)	`CAGGCC/GTGATG`	1	--	ut3¹		2		WA	120
rs145926038^1,2		--	40580524(+)	`AGTGGA/GGGTGA`	1	--	ut3¹		0	--	--	--	--
rs41277676^1,2	C,F,	--	40580654(+)	`AATATA/GTGACA`	1	--	ut3¹		1		NA	120
rs138602044^1,2		--	40580667(+)	`TATCTA/GGAGAT`	1	--	ut3¹		0	--	--	--	--
rs181845158^1,2		--	40580738(+)	`GAGGGA/TGCCTG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLCB2 (40570377 - 40600174 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for PLCB2
5 CNVs: 49550 47928 49551 49549 49552
1 Indel: 66775

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLCB2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLCB2 for disorders           About GeneDecksing

OMIM gene information: 604114    OMIM disorders: --

20/21 diseases for PLCB2 (see all 21):    About MalaCards

platelet plc beta-2 deficiency leiomyosarcoma prostate leiomyosarcoma balanitis

chagas disease neurologic diseases trypanosomiasis endocarditis

huntington's disease pertussis osteosarcoma breast cancer

sarcoma prostatitis immunodeficiency pancreatitis

malaria leukemia neuronitis glioblastoma

1 disease from the University of Copenhagen DISEASES database for PLCB2:

Prostate leiomyosarcoma

1 Novoseek disease relationship for PLCB2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0	1	16525635 (1)

Genetic Association Database (GAD): PLCB2
Human Genome Epidemiology (HuGE) Navigator: PLCB2 (9 documents)

Export disorders for PLCB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLCB2 gene, integrated from 9 sources (see all 107):
(articles sorted by number of sources associating them with PLCB2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2. (PubMed id 1644792)^{1, 2, 3} Park D.... Rhee S.G. (1992)
Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. (PubMed id 15274049)^{1, 4, 9} Morris D.W....O'Donovan M.C. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization. (PubMed id 9925923)^{1, 3} Park S.H....Kim H. (1998)
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays. (PubMed id 16525635)^{1, 9} Bertagnolo V....Capitani S. (2006)
Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2. (PubMed id 15611108)^{1, 9} Bonacci T.M....Smrcka A.V. (2005)
PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors. (PubMed id 17478077)^{1, 9} Brugnoli F....Bertagnolo V. (2007)
Crystal structure of Rac1 bound to its effector phospholipase C- beta2. (PubMed id 17115053)^{2, 9} Jezyk M.R....Sondek J. (2006)
Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization. (PubMed id 17497434)^{1, 9} Sun L....Rao A.K. (2007)
Fluorescence studies suggest a role for alpha-synuclein in the phosphatidylinositol lipid signaling pathway. (PubMed id 15641770)^{1, 9} Narayanan V....Scarlata S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5330	HGNC: 9055	AceView: PLCB2	Ensembl:ENSG00000137841	euGenes: HUgn5330
ECgene: PLCB2	Kegg: 5330	H-InvDB: PLCB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PLCB2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PLCB2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PLCB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PLCB2 gene:
Search GeneIP for patents involving PLCB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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phospholipase C, beta 2

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PLCB2 Gene

phospholipase C, beta 2

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