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Aliases for PLCB2 Gene

Aliases for PLCB2 Gene

  • Phospholipase C Beta 2 2 3 5
  • Phosphoinositide Phospholipase C-Beta-2 3 4
  • EC 3.1.4.11 4 61
  • PLC-Beta-2 3 4
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-2 3
  • Phospholipase C, Beta 2 2
  • Phospholipase C-Beta-2 4

External Ids for PLCB2 Gene

Previous GeneCards Identifiers for PLCB2 Gene

  • GC15M035947
  • GC15M033475
  • GC15M038159
  • GC15M038296
  • GC15M038367
  • GC15M040580
  • GC15M017423

Summaries for PLCB2 Gene

Entrez Gene Summary for PLCB2 Gene

  • The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]

GeneCards Summary for PLCB2 Gene

PLCB2 (Phospholipase C Beta 2) is a Protein Coding gene. Diseases associated with PLCB2 include Prostate Leiomyosarcoma. Among its related pathways are Signaling in Gap Junctions and Serotonergic synapse. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCB1.

UniProtKB/Swiss-Prot for PLCB2 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Tocris Summary for PLCB2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCB2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCB2 Gene

Genomics for PLCB2 Gene

Regulatory Elements for PLCB2 Gene

Enhancers for PLCB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G040090 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 14.5 +207.6 207615 18.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 DNAJC17 ENSG00000259211 BMF CHST14 SRP14-AS1 SRP14 RAD51-AS1 PLCB2 BUB1B EIF2AK4
GH15G040306 1.2 FANTOM5 ENCODE 27.4 -0.1 -50 3.9 PKNOX1 FOXA2 ZNF121 KDM4B ZBTB11 CEBPB ELF1 ZNF589 SMARCA4 ZNF341 PLCB2 C15orf57 BAHD1 BMF ENSG00000259198
GH15G040044 2 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +257.6 257557 12.1 HDGF FOXA2 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 BMF PLCB2 EIF2AK4 SRP14 PAK6 ANKRD63 C15orf56 RPLP0P10 SRP14-AS1 GC15M040064
GH15G040080 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 +225.9 225857 3.5 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 ZNF766 SP5 MXD4 NFYC SRP14 SRP14-AS1 BMF EIF2AK4 ANKRD63 PAK6 C15orf56 PLCB2 RPLP0P10 SPINT1
GH15G040326 1.6 Ensembl ENCODE dbSUPER 11.5 -33.1 -33091 28.7 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF766 CBX5 KNSTRN DISP2 IVD ENSG00000259211 DNAJC17 BAHD1 ANKRD63 RPLP0P10 PLCB2 C15orf56
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLCB2 on UCSC Golden Path with GeneCards custom track

Promoters for PLCB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075493 373 2001 CTCF PKNOX1 MAX FEZF1 ZIC2 RELA ZNF121 POLR2A KDM5B KDM4B

Genomic Location for PLCB2 Gene

Chromosome:
15
Start:
40,278,176 bp from pter
End:
40,307,973 bp from pter
Size:
29,798 bases
Orientation:
Minus strand

Genomic View for PLCB2 Gene

Genes around PLCB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCB2 Gene

Proteins for PLCB2 Gene

  • Protein details for PLCB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00722-PLCB2_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
    Protein Accession:
    Q00722
    Secondary Accessions:
    • A8K6J2
    • B9EGH5

    Protein attributes for PLCB2 Gene

    Size:
    1185 amino acids
    Molecular mass:
    134024 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with RAC1.
    Miscellaneous:
    • The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.

    Three dimensional structures from OCA and Proteopedia for PLCB2 Gene

    Alternative splice isoforms for PLCB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCB2 Gene

Selected DME Specific Peptides for PLCB2 Gene

Q00722:
  • GCRCVELD
  • PLNHYFI
  • LCPRPEID
  • EFMRRPDK
  • ITHGFTMTT
  • RIYPKGTR
  • QQAKMAEYCR
  • ISGQFLS
  • SSHNTYL
  • VALNFQT
  • LSFENHVDS
  • DSSNYMPQ
  • EAIAESAFKTS
  • YNKRQMSR

Post-translational modifications for PLCB2 Gene

  • Ubiquitination at posLast=761761
  • Modification sites at PhosphoSitePlus

Domains & Families for PLCB2 Gene

Gene Families for PLCB2 Gene

Suggested Antigen Peptide Sequences for PLCB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLCB2: view

No data available for UniProtKB/Swiss-Prot for PLCB2 Gene

Function for PLCB2 Gene

Molecular function for PLCB2 Gene

GENATLAS Biochemistry:
phospholipase C,beta 2,predominantly expressed in hematopoietic cells,critical to many chemoattractant elicited responses,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Enzyme Numbers (IUBMB) for PLCB2 Gene

Gene Ontology (GO) - Molecular Function for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS --
GO:0004629 phospholipase C activity TAS,IEA 7649993
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCB2: view
genes like me logo Genes that share phenotypes with PLCB2: view

Animal Models for PLCB2 Gene

MGI Knock Outs for PLCB2:

Animal Model Products

miRNA for PLCB2 Gene

miRTarBase miRNAs that target PLCB2

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLCB2 Gene

Localization for PLCB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCB2 gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PLCB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLCB2 Gene

Pathways & Interactions for PLCB2 Gene

genes like me logo Genes that share pathways with PLCB2: view

Pathways by source for PLCB2 Gene

SIGNOR curated interactions for PLCB2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 1644792
GO:0007165 signal transduction IEA --
GO:0007202 activation of phospholipase C activity TAS 7649993
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
genes like me logo Genes that share ontologies with PLCB2: view

Drugs & Compounds for PLCB2 Gene

(3) Drugs for PLCB2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
calcium Nutra 0

(393) Additional Compounds for PLCB2 Gene - From: HMDB, Novoseek, and Tocris