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Aliases for PLCB2 Gene

Aliases for PLCB2 Gene

  • Phospholipase C, Beta 2 2 3
  • Phosphoinositide Phospholipase C-Beta-2 3 4
  • EC 3.1.4.11 4 63
  • PLC-Beta-2 3 4
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-2 3
  • Phospholipase C-Beta-2 4

External Ids for PLCB2 Gene

Previous GeneCards Identifiers for PLCB2 Gene

  • GC15M035947
  • GC15M033475
  • GC15M038159
  • GC15M038296
  • GC15M038367
  • GC15M040580
  • GC15M017423

Summaries for PLCB2 Gene

GeneCards Summary for PLCB2 Gene

PLCB2 (Phospholipase C, Beta 2) is a Protein Coding gene. Diseases associated with PLCB2 include prostate leiomyosarcoma. Among its related pathways are GPCR Pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding and phosphatidylinositol phospholipase C activity. An important paralog of this gene is PLCH1.

UniProtKB/Swiss-Prot for PLCB2 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes

Tocris Summary for PLCB2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLCB2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCB2 Gene

Genomics for PLCB2 Gene

Regulatory Elements for PLCB2 Gene

Genomic Location for PLCB2 Gene

Start:
40,278,176 bp from pter
End:
40,307,973 bp from pter
Size:
29,798 bases
Orientation:
Minus strand

Genomic View for PLCB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLCB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCB2 Gene

Proteins for PLCB2 Gene

  • Protein details for PLCB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00722-PLCB2_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
    Protein Accession:
    Q00722
    Secondary Accessions:
    • A8K6J2
    • B9EGH5

    Protein attributes for PLCB2 Gene

    Size:
    1185 amino acids
    Molecular mass:
    134024 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    • Interacts with RAC1
    Miscellaneous:
    • The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16

    Three dimensional structures from OCA and Proteopedia for PLCB2 Gene

    Alternative splice isoforms for PLCB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCB2 Gene

Proteomics data for PLCB2 Gene at MOPED

Post-translational modifications for PLCB2 Gene

  • Ubiquitination at Lys761
  • Modification sites at PhosphoSitePlus

Other Protein References for PLCB2 Gene

Domains for PLCB2 Gene

Gene Families for PLCB2 Gene

Suggested Antigen Peptide Sequences for PLCB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00722

UniProtKB/Swiss-Prot:

PLCB2_HUMAN :
  • Q00722
Domain:
  • Contains 1 C2 domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCB2: view

Function for PLCB2 Gene

Molecular function for PLCB2 Gene

GENATLAS Biochemistry: phospholipase C,beta 2,predominantly expressed in hematopoietic cells,critical to many chemoattractant elicited responses,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
UniProtKB/Swiss-Prot Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes

Enzyme Numbers (IUBMB) for PLCB2 Gene

Gene Ontology (GO) - Molecular Function for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IMP 8519600
GO:0004629 phospholipase C activity TAS 7649993
GO:0004871 signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PLCB2: view
genes like me logo Genes that share phenotypes with PLCB2: view

Animal Models for PLCB2 Gene

MGI Knock Outs for PLCB2:

Animal Model Products

CRISPR Products

miRNA for PLCB2 Gene

miRTarBase miRNAs that target PLCB2

No data available for Transcription Factor Targeting and HOMER Transcription for PLCB2 Gene

Localization for PLCB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCB2 Gene COMPARTMENTS Subcellular localization image for PLCB2 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PLCB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLCB2 Gene

Pathways for PLCB2 Gene

genes like me logo Genes that share pathways with PLCB2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006644 phospholipid metabolic process TAS 1644792
GO:0007165 signal transduction --
GO:0007202 activation of phospholipase C activity TAS 7649993
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with PLCB2: view

Compounds for PLCB2 Gene

(5) Tocris Compounds for PLCB2 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]
VU 0155069 Potent and selective PLD1 inhibitor [1130067-06-9]
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor [1244640-48-9]

(1226) HMDB Compounds for PLCB2 Gene

Compound Synonyms Cas Number PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available

(8) Novoseek inferred chemical compound relationships for PLCB2 Gene

Compound -log(P) Hits PubMed IDs
guanosine 5-o-(3-thiotriphosphate) 44.1 2
phosphatidylinositol 40.8 3
leukotriene b4 40.1 1
fmlp 29.7 1
phosphoinositide 18.9 2
genes like me logo Genes that share compounds with PLCB2: view

Transcripts for PLCB2 Gene

Unigene Clusters for PLCB2 Gene

Phospholipase C, beta 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLCB2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PLCB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1: - - - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b
SP1: - - - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - -
SP8: -
SP9:
SP10:
SP11:
SP12: - - -
SP13: - - -
SP14:
SP15:

Relevant External Links for PLCB2 Gene

GeneLoc Exon Structure for
PLCB2
ECgene alternative splicing isoforms for
PLCB2

Expression for PLCB2 Gene

mRNA expression in normal human tissues for PLCB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCB2 Gene

This gene is overexpressed in Whole Blood (16.9) and Spleen (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLCB2 Gene

SOURCE GeneReport for Unigene cluster for PLCB2 Gene Hs.355888

genes like me logo Genes that share expressions with PLCB2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PLCB2 Gene

Orthologs for PLCB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCB2 35
  • 99.57 (n)
  • 99.66 (a)
PLCB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLCB2 35
  • 89.3 (n)
  • 90.23 (a)
PLCB2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCB2 35
  • 89.8 (n)
  • 91.97 (a)
PLCB2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcb2 35
  • 85.57 (n)
  • 86.68 (a)
Plcb2 16
Plcb2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLCB2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcb2 35
  • 85.25 (n)
  • 86.68 (a)
chicken
(Gallus gallus)
Aves PLCB2 35
  • 72.14 (n)
  • 73 (a)
PLCB2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCB2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plcb2 35
  • 68.16 (n)
  • 70.13 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11385 35
PLCB2 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Plc21C 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y75B12B.6 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for PLCB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCB2 Gene

ENSEMBL:
Gene Tree for PLCB2 (if available)
TreeFam:
Gene Tree for PLCB2 (if available)

Paralogs for PLCB2 Gene

Paralogs for PLCB2 Gene

Selected SIMAP similar genes for PLCB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PLCB2: view

Variants for PLCB2 Gene

Sequence variations from dbSNP and Humsavar for PLCB2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs936209 -- 40,291,257(-) AAGGC(C/T)CGTGG intron-variant
rs936210 -- 40,290,446(-) ATCCC(A/C)CCTGT intron-variant
rs936211 -- 40,290,298(-) TCCCA(A/C)GGAAG intron-variant
rs936212 - 40,289,342(-) CTTGG(A/G)GAGGC reference, missense, utr-variant-3-prime, nc-transcript-variant
rs936213 -- 40,289,144(-) GGTCC(A/C/G/T)GAGGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PLCB2 Gene

Variant ID Type Subtype PubMed ID
nsv904095 CNV Loss 21882294
nsv471240 CNV Loss 18288195
esv34145 CNV Loss 18971310
dgv2359n71 CNV Loss 21882294
nsv510660 CNV Loss 20534489
nsv517541 CNV Loss 19592680
nsv904098 CNV Loss 21882294
nsv457118 CNV Loss 19166990
esv22666 CNV Loss 19812545
nsv827305 CNV Gain 20364138

Relevant External Links for PLCB2 Gene

HapMap Linkage Disequilibrium report
PLCB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCB2 Gene

Disorders for PLCB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PLCB2 Gene including...

Search for PLCB2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PLCB2 Gene

(1) Novoseek inferred disease relationships for PLCB2 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for PLCB2

Genetic Association Database (GAD)
PLCB2
Human Genome Epidemiology (HuGE) Navigator
PLCB2
genes like me logo Genes that share disorders with PLCB2: view

No data available for UniProtKB/Swiss-Prot for PLCB2 Gene

Publications for PLCB2 Gene

  1. Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. (PMID: 15274049) Morris D.W. … O'Donovan M.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004) 3 23 48
  2. Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2. (PMID: 1644792) Park D. … Rhee S.G. (J. Biol. Chem. 1992) 2 3 4
  3. Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization. (PMID: 9925923) Park S.H. … Kim H. (Cytogenet. Cell Genet. 1998) 2 3
  4. Phospholipase Cbeta2 binds to and inhibits phospholipase Cdelta1. (PMID: 15509571) Guo Y. … Scarlata S. (J. Biol. Chem. 2005) 3 23
  5. Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2. (PMID: 15611108) Bonacci T.M. … Smrcka A.V. (J. Biol. Chem. 2005) 3 23

Products for PLCB2 Gene

Sources for PLCB2 Gene

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