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Aliases for PLCB2 Gene

Aliases for PLCB2 Gene

  • Phospholipase C Beta 2 2 3 5
  • Phosphoinositide Phospholipase C-Beta-2 3 4
  • Phospholipase C, Beta 2 2 3
  • EC 3.1.4.11 4 63
  • PLC-Beta-2 3 4
  • Phospholipase C-Beta-2 4

External Ids for PLCB2 Gene

Previous GeneCards Identifiers for PLCB2 Gene

  • GC15M035947
  • GC15M033475
  • GC15M038159
  • GC15M038296
  • GC15M038367
  • GC15M040580
  • GC15M017423

Summaries for PLCB2 Gene

GeneCards Summary for PLCB2 Gene

PLCB2 (Phospholipase C Beta 2) is a Protein Coding gene. Diseases associated with PLCB2 include Prostate Leiomyosarcoma. Among its related pathways are Platelet activation and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCB3.

UniProtKB/Swiss-Prot for PLCB2 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Tocris Summary for PLCB2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCB2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCB2 Gene

Genomics for PLCB2 Gene

Regulatory Elements for PLCB2 Gene

Enhancers for PLCB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLCB2 on UCSC Golden Path with GeneCards custom track

Promoters for PLCB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLCB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLCB2 Gene

Chromosome:
15
Start:
40,278,176 bp from pter
End:
40,307,973 bp from pter
Size:
29,798 bases
Orientation:
Minus strand

Genomic View for PLCB2 Gene

Genes around PLCB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCB2 Gene

Proteins for PLCB2 Gene

  • Protein details for PLCB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00722-PLCB2_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
    Protein Accession:
    Q00722
    Secondary Accessions:
    • A8K6J2
    • B9EGH5

    Protein attributes for PLCB2 Gene

    Size:
    1185 amino acids
    Molecular mass:
    134024 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with RAC1.
    Miscellaneous:
    • The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.

    Three dimensional structures from OCA and Proteopedia for PLCB2 Gene

    Alternative splice isoforms for PLCB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCB2 Gene

Proteomics data for PLCB2 Gene at MOPED

Post-translational modifications for PLCB2 Gene

  • Ubiquitination at Lys 761
  • Modification sites at PhosphoSitePlus

Domains & Families for PLCB2 Gene

Gene Families for PLCB2 Gene

Suggested Antigen Peptide Sequences for PLCB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00722

UniProtKB/Swiss-Prot:

PLCB2_HUMAN :
  • Contains 1 C2 domain.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with PLCB2: view

Function for PLCB2 Gene

Molecular function for PLCB2 Gene

GENATLAS Biochemistry:
phospholipase C,beta 2,predominantly expressed in hematopoietic cells,critical to many chemoattractant elicited responses,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Enzyme Numbers (IUBMB) for PLCB2 Gene

Gene Ontology (GO) - Molecular Function for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS --
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCB2: view
genes like me logo Genes that share phenotypes with PLCB2: view

Animal Models for PLCB2 Gene

MGI Knock Outs for PLCB2:

Animal Model Products

miRNA for PLCB2 Gene

miRTarBase miRNAs that target PLCB2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLCB2 Gene

Localization for PLCB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLCB2 Gene COMPARTMENTS Subcellular localization image for PLCB2 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 2
cytoskeleton 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLCB2 Gene

Pathways & Interactions for PLCB2 Gene

genes like me logo Genes that share pathways with PLCB2: view

Pathways by source for PLCB2 Gene

SIGNOR curated interactions for PLCB2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 1644792
GO:0007165 signal transduction IEA --
GO:0007202 activation of phospholipase C activity TAS 7649993
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with PLCB2: view

Drugs & Compounds for PLCB2 Gene

(2) Drugs for PLCB2 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
D609 Pharma PC-PLC inhibitor, Selective PC-PLC inhibitor 0

(397) Additional Compounds for PLCB2 Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PLCB2 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
RHC 80267 Diacylglycerol lipase inhibitor 83654-05-1
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCB2: view

Transcripts for PLCB2 Gene

Unigene Clusters for PLCB2 Gene

Phospholipase C, beta 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLCB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1: - - - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b
SP1: - - - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - -
SP8: -
SP9:
SP10:
SP11:
SP12: - - -
SP13: - - -
SP14:
SP15:

Relevant External Links for PLCB2 Gene

GeneLoc Exon Structure for
PLCB2
ECgene alternative splicing isoforms for
PLCB2

Expression for PLCB2 Gene

mRNA expression in normal human tissues for PLCB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCB2 Gene

This gene is overexpressed in Whole Blood (x16.9) and Spleen (x6.9).

Protein differential expression in normal tissues from HIPED for PLCB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.7) and Spleen (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLCB2 Gene



SOURCE GeneReport for Unigene cluster for PLCB2 Gene Hs.355888

genes like me logo Genes that share expression patterns with PLCB2: view

Protein tissue co-expression partners for PLCB2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PLCB2 Gene

Orthologs for PLCB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLCB2 35
  • 89.3 (n)
  • 90.23 (a)
PLCB2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCB2 35
  • 89.8 (n)
  • 91.97 (a)
PLCB2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcb2 35
  • 85.57 (n)
  • 86.68 (a)
Plcb2 16
Plcb2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLCB2 35
  • 99.57 (n)
  • 99.66 (a)
PLCB2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcb2 35
  • 85.25 (n)
  • 86.68 (a)
oppossum
(Monodelphis domestica)
Mammalia PLCB2 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLCB2 35
  • 72.14 (n)
  • 73 (a)
PLCB2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCB2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plcb2 35
  • 68.16 (n)
  • 70.13 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11385 35
PLCB2 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Plc21C 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y75B12B.6 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for PLCB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCB2 Gene

ENSEMBL:
Gene Tree for PLCB2 (if available)
TreeFam:
Gene Tree for PLCB2 (if available)

Paralogs for PLCB2 Gene

Paralogs for PLCB2 Gene

(8) SIMAP similar genes for PLCB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PLCB2: view

Variants for PLCB2 Gene

Sequence variations from dbSNP and Humsavar for PLCB2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs45628633 - 40,298,588(-) CATCA(A/T)CTCGT nc-transcript-variant, reference, missense
rs8025153 - 40,295,049(+) TCTGG(C/T)GCTTG nc-transcript-variant, reference, missense
rs9972332 - 40,294,336(+) TGTCC(A/G/T)GCCGG nc-transcript-variant, reference, missense
rs28395835 - 40,293,652(-) TTCCT(A/G)GGGAC nc-transcript-variant, reference, missense
rs936212 - 40,289,342(-) CTTGG(A/G)GAGGC nc-transcript-variant, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PLCB2 Gene

Variant ID Type Subtype PubMed ID
nsv904095 CNV Loss 21882294
nsv471240 CNV Loss 18288195
esv34145 CNV Loss 18971310
dgv2359n71 CNV Loss 21882294
nsv510660 CNV Loss 20534489
nsv517541 CNV Loss 19592680
nsv904098 CNV Loss 21882294
nsv457118 CNV Loss 19166990
esv22666 CNV Loss 19812545
nsv827305 CNV Gain 20364138

Variation tolerance for PLCB2 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.04; 80.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLCB2 Gene

Disorders for PLCB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLCB2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prostate leiomyosarcoma
  • leiomyosarcoma of the prostate
- elite association - COSMIC cancer census association via MalaCards
Search PLCB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLCB2

Genetic Association Database (GAD)
PLCB2
Human Genome Epidemiology (HuGE) Navigator
PLCB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLCB2
genes like me logo Genes that share disorders with PLCB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLCB2 Gene

Publications for PLCB2 Gene

  1. Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2. (PMID: 1644792) Park D. … Rhee S.G. (J. Biol. Chem. 1992) 2 3 4 67
  2. Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells. (PMID: 17429106) Bertagnolo V. … Capitani S. (Carcinogenesis 2007) 3 23
  3. PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors. (PMID: 17478077) Brugnoli F. … Bertagnolo V. (Cell. Signal. 2007) 3 23
  4. Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization. (PMID: 17497434) Sun L. … Rao A.K. (Platelets 2007) 3 23
  5. PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays. (PMID: 16525635) Bertagnolo V. … Capitani S. (Int. J. Oncol. 2006) 3 23

Products for PLCB2 Gene

Sources for PLCB2 Gene