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PLCB2 Gene

protein-coding GIFtS: 69

GC15M038367

phospholipase C, beta 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.4.11 ^³
FLJ38135 ^¹, ²
PLC-beta-2 ^³

Descriptions
Phosphoinositide phospholipase C ^³
Phospholipase C-beta-2 ^³
phospholipase C, beta 2 ^²

External Ids
HGNC: 9055¹
Entrez Gene: 5330²
UniProtKB: Q00722³
Ensembl: ENSG00000137841⁷

Search outside databases for aliases for PLCB2 gene

Previous GC identifers: GC15M035947 GC15M033475 GC15M038159 GC15M038296

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol

1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C

enzymes

Gene Wiki entry for PLCB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PLCB2 gene

Entrez Gene cytogenetic band: 15q15 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q15

PLCB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M038367: (about GC identifiers)

Start:	38,367,390 bp from pter
End:	38,387,466 bp from pter
Size:	20,077 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722 (See protein sequence)

Recommended Name: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2

Size: 1185 amino acids; 134024 Da

Cofactor: Binds 1 calcium ion per subunit

Subunit: Interacts with RAC1

Miscellaneous: The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one

G-protein alpha subunit, alpha-16

PDB structure from and Proteopedia :

2FJU (3D)

2ZKM (3D)

Secondary accessions: A8K6J2

Alternative splicing: 2 isoforms: Q00722-1 Q00722-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004564.2

ENSEMBL proteins:

ENSP00000374462 ENSP00000260402

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PLCB2
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (PLCB2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for PLCB2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PLCB2
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (PLCB2)
	Novus Biologicals Antibody for PLCB2

Assays for PLCB2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q00722

ProtoNet protein and cluster: Q00722

2 Blocks protein families:

IPB000008 C2 domain

IPB000909 Phosphatidylinositol-specific phospholipase C

UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722

Similarity: Contains 1 C2 domain

Similarity: Contains 1 PI-PLC X-box domain

Similarity: Contains 1 PI-PLC Y-box domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PLCB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PLCB2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004573

Applied Biosystems Silencer® siRNAs for PLCB2

Sigma-Aldrich siRNA and siRNA Panels for PLCB2

Sigma-Aldrich shRNA for PLCB2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PLCB2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004573
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004573
untagged cDNA clones in CMV expression vector (see all 2): NM_004573

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004573

UniProtKB/Swiss-Prot: PLCB2_HUMAN, Q00722

Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol

1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C

enzymes

Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol

1,4,5-trisphosphate + diacylglycerol

Enzyme Number (IUBMB): EC 3.1.4.11

Genatlas biochemistry entry for PLCB2:

phospholipase C,beta 2,predominantly expressed in hematopoietic cells,critical to many

chemoattractant elicited responses,involved in signal transduction

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Plcb2):

immune system

taste/olfaction

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphoinositide phospholipase C activity	TAS	1644792
GO:0004871	signal transducer activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/28 Sigma-Aldrich "Your Favorite Gene" Pathways for PLCB2 (Your Favorite Gene powered by Ingenuity) (see all 28 )

Cholecystokinin/Gastrin-mediated Signaling
CCR3 Signaling in Eosinophils
Role of NFAT in Regulation of the Immune Response
CXCR4 Signaling
Endothelin-1 Signaling

GeneDecks PLCB2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PLCB2

5/125 Interacting proteins for PLCB2 (Q00722² ENSP00000260402³) via UniProtKB, MINT, and/or STRING (see all 125 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAQ	ENSP00000286548³	STRING (score=.988)
ITPR3	ENSP00000363435³	STRING (score=.969)
SUCLG2	ENSP00000307432³	STRING (score=.965)
MAPK14	ENSP00000229794³	STRING (score=.959)
GNB3	ENSP00000229264³	STRING (score=.955)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	1644792
GO:0007202	activation of phospholipase C activity	TAS	7649993
GO:0007242	intracellular signaling cascade	IEA	--
GO:0016042	lipid catabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for PLCB2 available from Tocris Bioscience

Compound	Action	CAS number
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
U 73122	Phospholipase C inhibitor	[112648-68-7]
D609	Selective PC-PLC inhibitor	[83373-60-8]

About this table

7 Novoseek chemical compound relationships for PLCB2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
guanosine 5'-o-(3-thiotriphosphate)	44.79	3	9799233 (2)
phosphatidylinositol	42.05	3	9020783 (1), 12761218 (1), 8132501 (1)
leukotriene b4	41.01	1	11806993 (1)
fmlp	30.51	1	11806993 (1)
phosphoinositide	20.52	2	17478077 (2)
calcium	19.62	4	8223634 (1), 11806993 (1)
phospholipid	14.69	4	9020783 (1), 8223634 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PLCB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PLCB2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004573

Sigma-Aldrich siRNA and siRNA Panels for PLCB2

Sigma-Aldrich shRNA for PLCB2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004573

REFSEQ mRNAs for PLCB2 gene:

NM_004573.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004573

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004573
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004573
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004573

Additional cDNA sequence:

AB209583.1 AK095454.1 AK130831.1 AK291657.1 BC000939.3 BC009009.1 BC136467.1 BT006905.1

CR601877.1 M95678.1

13 DOTS entries:

DT.112491 DT.86857819 DT.121039156 DT.91717568 DT.95215191 DT.95278919 DT.121039181 DT.91956934

DT.95169486 DT.100775471 DT.455229 DT.86839669 DT.91717581

24/125 AceView cDNA sequences (see all 125 ):

AI655426 AW630959 CB126410 CD369500 AW294690 BC009009 AW402206 CR601877

F12578 T28538 T89023 BX099469 CF136301 BM667278 AA310466 BF902936

AK130831 F04675 AA464970 BE242666 BG258587 AW292822 BI909727 AW950600

highest scoring ESTs for PLCB2:

M95678 BC000939 BC009009 BE242666 BE539724 BE540889 BF899548 BF922182 BM147371 BM148103

Unigene Cluster for PLCB2:

Phospholipase C, beta 2

Hs.355888 [show with all ESTs]

Unigene Representative Sequence: NM_004573

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for PLCB2 (see all 15 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19a	·	19b	^
SP1:																																	-								-		-		-		-		-		-
SP2:							-
SP3:
SP4:
SP5:

ExUns:	20a	·	20b	^	21	^	22a	·	22b	^	23	^	24	^	25a	·	25b	·	25c	·	25d	^	26a	·	26b	·	26c	^	27	^	28	^	29	^	30a	·	30b	^	31	^	32a	·	32b
SP1:	-		-		-		-		-		-		-		-		-		-		-		-														-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PLCB2

2 Ensembl transcripts including schematic representations:

ENST00000389812 ENST00000260402

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PLCB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PLCB2

¹ / ² / ³

5 probe-sets matching PLCB2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
210_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M95678	1.00	1.00	1.00	1
210388_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000939	0.80	1.00	0.91	1
204046_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004573	0.60	1.00	0.82	1
210388_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204046_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACCCCTCTC

SOURCE GeneReport for Unigene cluster: Hs.355888
Expression variation in blood from EXPOLDB for PLCB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PLCB2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PLCB2¹	--	phospholipase C, beta 2	89.79(n) 91.81(a)	487491 XM_544615.2 XP_544615.2
chimpanzee (Pan troglodytes)	PLCB2¹	--	phospholipase C, beta 2	99.58(n) 99.66(a)	453330 XM_001141721.1 XP_001141721.1
rat (Rattus norvegicus)	Plcb2¹	--	phospholipase C, beta 2	85.07(n) 86.34(a)	85240 NM_053478.1 NP_445930.1
mouse (Mus musculus)	Plcb2^{1, 5}	2 (67.00 cM)⁵	phospholipase C, beta 2^{1, 5}	85.72(n)¹ 86.51(a)¹	18796¹ NM_177568.2¹ NP_808236.2¹ AF022802⁵ AI550384⁵ (see all 20)
chicken (Gallus gallus)	PLCB2¹	--	phospholipase C, beta 2	71.86(n) 72.32(a)	423014 XM_420945.2 XP_420945.2

About this table Species with no ortholog for PLCB2

ENSEMBL Gene Tree for PLCB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PLCB2 gene

PLCB3² PLCB4² PLCB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/176 NCBI SNPs in PLCB2 are shown (see all 176 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 74)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs936212^1,2	A,C,F,H	38368835(-)	`CTTGGA/GGAGGC`	1	E/G	mis¹		12		MN EU EA WA	1164
	rs3784400^1,2	C,F,H	38387490(+)	`CCCCAC/GCCCCA`	1	--	ng3¹		4		EU EA WA	414
--	rs6492942^1,2	C	38388915(+)	`TCTTCC/TTCCTC`	1	--	ng3¹ trp³		0	--	--	--	--
--	rs28395835^1,2	F	38373145(-)	`TTCCTG/AGGGAC`	1	R/G	mis¹		1		--	64
	rs4923861^1,2	C	38389369(+)	`GGACCA/CCAACT`	1	--	ng3¹		0	--	--	--	--
	rs9972332^1,2	H	38373829(+)	`TGTCCG/AGCCGG`	1	L/P	mis¹ ese³		4		EU EA WA	420
--	rs4923860^1,2	C	38387949(+)	`aatccC/Tagcac`	1	--	ng3¹		0	--	--	--	--
--	rs45628633^1,2	F	38378081(-)	`CATCAA/TCTCGT`	1	N/I	mis¹		1		--	58
	rs8025153^1,2	H	38374542(+)	`TCTGGC/TGCTTG`	1	R/H	mis¹ ese³		4		EU EA WA	406
	rs2229691^1,2	C,F,H	38376294(-)	`GATACC/TGGTGG`	1	T/T	syn¹		9		MN EA NA EU WA	2096

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HapMap Linkage Disequilibrium images for PLCB2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604114

1 Novoseek disease relationship for PLCB2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0.00	1	16525635 (1)

About this table

Genetic Association Database: PLCB2
Human Genome Epidemiology Navigator: PLCB2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/84 PubMed articles for PLCB2 gene (see all 84 ):

Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2. (PubMed id 1644792)^{2, 3, 4} Park D.... Rhee S.G. (1992)
Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. (PubMed id 15274049)^{1, 3, 6} Morris D.W....O'Donovan M.C. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization. (PubMed id 9925923)^{2, 3} Park S.H....Kim H. (1998)
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays. (PubMed id 16525635)^{1, 3} Bertagnolo V....Capitani S. (2006)
Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2. (PubMed id 15611108)^{1, 3} Bonacci T.M....Smrcka A.V. (2005)
PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors. (PubMed id 17478077)^{1, 3} Brugnoli F....Bertagnolo V. (2007)
Crystal structure of Rac1 bound to its effector phospholipase C- beta2. (PubMed id 17115053)^{1, 4} Jezyk M.R....Sondek J. (2006)
Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization. (PubMed id 17497434)^{1, 3} Sun L....Rao A.K. (2007)
The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site. (PubMed id 12761218)^{1, 3} Guo Y....Scarlata S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5330	HGNC: 9055	AceView: PLCB2	Ensembl:ENSG00000137841	euGenes: HUgn5330
ECgene: PLCB2	H-InvDB: PLCB2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PLCB2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PLCB2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PLCB2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PLCB2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PLCB2		Antibodies for PLCB2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PLCB2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PLCB2)
	Antibodies (PLCB2)
	Chimera RNAi (PLCB2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for PLCB2

Tocris compounds for PLCB2

	Proteins for PLCB2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PLCB2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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PLCB2 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for PLCB2

Summaries
for PLCB2

Genomic Location
for PLCB2

Proteins
for PLCB2

Protein Domains/
Families
for PLCB2

Gene Function
for PLCB2

Pathways & Interactions
for PLCB2

Drugs & Compounds
for PLCB2

Transcripts
for PLCB2

Expression
for PLCB2

Orthologs
for PLCB2

Paralogs
for PLCB2

SNPs/Variants
for PLCB2

Disorders & Mutations
for PLCB2

Medical News
for PLCB2

Publications
for PLCB2

Search for PLCB2

Genome Databases showing PLCB2

Other Databases showing PLCB2

Specialized Databases showing PLCB2

Licensable Technologies
for PLCB2

Services
for PLCB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PLCB2 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor PLCB2

Summariesfor PLCB2

Genomic Locationfor PLCB2

Proteinsfor PLCB2

Protein Domains/Familiesfor PLCB2

Gene Functionfor PLCB2

Pathways & Interactionsfor PLCB2

Drugs & Compoundsfor PLCB2

Transcriptsfor PLCB2

Expression for PLCB2

Orthologsfor PLCB2

Paralogsfor PLCB2

SNPs/Variantsfor PLCB2

Disorders & Mutationsfor PLCB2

Medical Newsfor PLCB2

Publicationsfor PLCB2

Search for PLCB2

Genome Databases showing PLCB2

Other Databases showing PLCB2

Specialized Databases showing PLCB2

Licensable Technologiesfor PLCB2

Servicesfor PLCB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PLCB2

Summaries
for PLCB2

Genomic Location
for PLCB2

Proteins
for PLCB2

Protein Domains/
Families
for PLCB2

Gene Function
for PLCB2

Pathways & Interactions
for PLCB2

Drugs & Compounds
for PLCB2

Transcripts
for PLCB2

Expression
for PLCB2

Orthologs
for PLCB2

Paralogs
for PLCB2

SNPs/Variants
for PLCB2

Disorders & Mutations
for PLCB2

Medical News
for PLCB2

Publications
for PLCB2

Licensable Technologies
for PLCB2

Services
for PLCB2