Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PLCB1 Gene

protein-coding   GIFtS: 70
GCID: GC20P008061

Phospholipase C, Beta 1 (Phosphoinositide-Specific)

  See PLCB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
Phospholipase C, Beta 1 (Phosphoinositide-Specific)1 2     1-phosphatidyl-D-myo-inositol-4,5-bisphosphate2
Phospholipase C-I2 3     1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-12
PLC-1542 3     PI-PLC2
PLC-I2 3     PLC1542
PLC-beta-12 3     inositoltrisphosphohydrolase2
EC 3.1.4.113 8     Monophosphatidylinositol Phosphodiesterase2
EIEE122 5     Phosphoinositidase C2
PLCB1A2 5     Triphosphoinositide Phosphodiesterase2
PLCB1B2 5     Phosphoinositide Phospholipase C-Beta-13
KIAA05813 5     Phospholipase C-Beta-13

External Ids:    HGNC: 159171   Entrez Gene: 232362   Ensembl: ENSG000001826217   OMIM: 6071205   UniProtKB: Q9NQ663   

Export aliases for PLCB1 gene to outside databases

Previous GC identifiers: GC20P008101 GC20P008108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section


Entrez Gene summary for PLCB1 Gene:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from
phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in
the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha
subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PLCB1 Gene:
PLCB1 (phospholipase C, beta 1 (phosphoinositide-specific)) is a protein-coding gene. Diseases associated with PLCB1 include epileptic encephalopathy, early infantile, 12, and epileptic encephalopathy, early infantile, 2. GO annotations related to this gene include signal transducer activity and calcium ion binding. An important paralog of this gene is PLCD4.

UniProtKB/Swiss-Prot: PLCB1_HUMAN, Q9NQ66
Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
(IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes

summary for PLCB1 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLC is subdivided into beta, gamma, delta, epsilon, zeta and eta subtypes, which catalyze the
hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and
1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions. PLC-beta is primarily
activated by Gq/11 proteins and PLC-gamma is activated by phosphorylation in response to a variety of growth
factor and immune system signals. Phospholipases are ubiquitously expressed and have diverse biological
functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane
phospholipids.

Gene Wiki entry for PLCB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLCB1 gene promoter:
         CBF-B   CBF-A   Pax-5   GATA-3   CP1A   NF-Y   CBF(2)   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PLCB1 promoter sequence
   Search Chromatin IP Primers for PLCB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p12

PLCB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLCB1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P008061:  view genomic region     (about GC identifiers)

Start:
8,112,824 bp from pter      End:
8,949,003 bp from pter
Size:
836,180 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section


UniProtKB/Swiss-Prot: PLCB1_HUMAN, Q9NQ66 (See protein sequence)
Recommended Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1  
Size: 1216 amino acids; 138567 Da
Cofactor: Calcium
Subunit: Interacts with DGKQ
Miscellaneous: The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q
and alpha-11
Sequence caution: Sequence=BAA25507.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14641.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: D3DW12 D3DW13 O60325 Q17RQ6 Q5TFF7 Q5TGC9 Q8IV93 Q9BQW2 Q9H4H2 Q9H8H5
Q9NQ65 Q9NQH9 Q9NTH4 Q9UJP6 Q9UM26
Alternative splicing: 2 isoforms:  Q9NQ66-1   Q9NQ66-2   

Explore the universe of human proteins at neXtProt for PLCB1: NX_Q9NQ66

Explore proteomics data for PLCB1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PLCB1 (Q9NQ66) (see all 32)
     EFVEYNK  KRVETAL  GHRILPV  QLSRIYP 


    See PLCB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056007.1  NP_877398.1  

    ENSEMBL proteins: 
     ENSP00000367908   ENSP00000338185   ENSP00000367904   ENSP00000384001   ENSP00000431704  
     ENSP00000391162   ENSP00000389911  
    Reactome Protein details: Q9NQ66

    PLCB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for PLCB1
    OriGene Protein Over-expression Lysate for PLCB1
    OriGene MassSpec for PLCB1
    OriGene Custom Protein Services for PLCB1
    GenScript Custom Purified and Recombinant Proteins Services for PLCB1
    Novus Biologicals PLCB1 Protein
    Novus Biologicals PLCB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PLCB1 

     
    antibodies-online proteins for PLCB1 (2 products) 

     
    antibodies-online peptides for PLCB1

     
    Search GeneTex for Proteins for PLCB1 

    PLCB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PLCB1
    R&D Systems Antibodies for PLCB1 (PLC-beta 1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PLCB1
    Novus Biologicals PLCB1 Antibodies
    Abcam antibodies for PLCB1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PLCB1
    antibodies-online antibodies for PLCB1 (43 products) 

     
    GeneTex Antibodies for PLCB1:  
                        PLCB1 Antibodies

    PLCB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PLCB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PLCB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PLCB1 
    antibodies-online kits for PLCB1 (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    IUPHAR Guide to PHARMACOLOGY protein family classification: PLCbeta1
    Phosphoinositide-specific phospholipase C

    Selected InterPro protein domains (see all 10):
     IPR015359 PLipase_C_EF-hand-like
     IPR011992 EF-hand-dom_pair
     IPR001192 PI-PLC_fam
     IPR016280 PLC-beta
     IPR014815 PLC-beta_C

    Graphical View of Domain Structure for InterPro Entry Q9NQ66

    ProtoNet protein and cluster: Q9NQ66

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB000909 Phosphatidylinositol-specific phospholipase C


    UniProtKB/Swiss-Prot: PLCB1_HUMAN, Q9NQ66
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PI-PLC X-box domain
    Similarity: Contains 1 PI-PLC Y-box domain


    Find genes that share domains with PLCB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLCB1_HUMAN, Q9NQ66
    Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate
    (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate
    + diacylglycerol

         Genatlas biochemistry entry for PLCB1:
    phospholipase C,beta 1,phosphatidylinositol specific,involved in signal transduction

         Enzyme Number (IUBMB): EC 3.1.4.111 2

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity NAS11118617
    GO:0004871signal transducer activity IEA--
    GO:0005096GTPase activator activity IDA1322796
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PLCB1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PLCB1:
     Increased cilium length after   Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plcb1):
     behavior/neurological  growth/size/body  mortality/aging  nervous system 

    Find genes that share phenotypes with PLCB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Plcb1tm1Hssh for PLCB1

       genOway: Develop your customized and physiologically relevant rodent model for PLCB1

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for PLCB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLCB1:
    hsa-mir-30c-5p (MIRT047991), hsa-mir-423-5p (MIRT038084)

    Block miRNA regulation of human, mouse, rat PLCB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLCB1 (see all 46):
    hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-183* hsa-miR-124 hsa-miR-3658 hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLCB1
    Predesigned siRNA for gene silencing in human, mouse, rat PLCB1

    Clone
    Products:
         
    OriGene clones in human, mouse for PLCB1 (see all 13)
    OriGene ORF clones in mouse, rat for PLCB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLCB1 (NM_182734)
    Browse Sino Biological Human cDNA Clones
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCB1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLCB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PLCB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Subcellular locations from UniProtKB/Swiss-Prot
    PLCB1_HUMAN, Q9NQ66: Nucleus membrane (By similarity). Cytoplasm (By similarity). Note=Colocalizes with the
    adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin ISS--
    GO:0005634nucleus NAS10760467
    GO:0005737cytoplasm IDA11118617
    GO:0005829cytosol TAS--
    GO:0016607nuclear speck IDA12799190

    Find genes that share ontologies with PLCB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section






    SuperPaths for PLCB1 About   (see all 79)  
    See pathways by source

          Powered
    by
         
    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    G-protein beta-gamma signalling0.90
    Activation of Kainate Receptors upon glutamate binding0.68
    G beta-gamma signalling through PLC beta0.79
    G-Protein Signaling through Tubby Protein0.35
    Presynaptic function of Kainate receptors0.76
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    2Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.36
    Phosphatidylinositol signaling system0.61
    D-myo-inositol-5-phosphate metabolism0.00
    superpathway of inositol phosphate compounds0.60
    3fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    CXCR4 Pathway0.39
    fMLP Pathway0.43
    Huntington's Disease Pathway0.30
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    4Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA transactivation of EGFR0.41
    Inflammatory mediator regulation of TRP channels0.37
    Cytoskeleton remodeling FAK signaling0.41
    Estrogen signaling pathway0.34
    GnRH signaling pathway0.38
    5Ca-dependent events
    PLC beta mediated events0.67
    Opioid Signalling0.54
    G-protein mediated events0.65
    Signal transduction Calcium signaling0.35


    Find genes that share SuperPaths with PLCB1           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PLCB1
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLCB1 (see all 55)
        Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    Aldosterone Signaling in Epithelial Cells

    Selected GeneGo (Thomson Reuters) Pathways for PLCB1 (see all 22)
        Anandamide biosynthesis and metabolism
    Development Endothelin-1/EDNRA transactivation of EGFR
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Development Angiotensin signaling via PYK2
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    Selected BioSystems Pathways for PLCB1 (see all 12)
        Signal Transduction of S1P Receptor
    AMPK signaling
    D-myo-inositol-5-phosphate metabolism
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis
    Alzheimers Disease

    Selected Reactome Pathways for PLCB1 (see all 8)
        Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
    Presynaptic function of Kainate receptors
    Synthesis of IP3 and IP4 in the cytosol
    Acetylcholine regulates insulin secretion
    PLC beta mediated events

    4 PharmGKB Pathways for PLCB1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PLCB1) (see all 35):
        Inositol phosphate metabolism
    Metabolic pathways
    Rap1 signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLCB1: 
              GABA & Glutamate in human mouse rat
              Huntington's Disease in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLCB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLCB1 (Q9NQ663 ENSP000003381854) via UniProtKB, MINT, STRING, and/or I2D (see all 293)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAQP501483, ENSP000002865484I2D: score=2 STRING: ENSP00000286548
    PARD3Q8TEW03, ENSP000003639214I2D: score=2 STRING: ENSP00000363921
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    MAPK1P284823, ENSP000002158324I2D: score=1 STRING: ENSP00000215832
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle ISS--
    GO:0006629lipid metabolic process ----
    GO:0007165signal transduction NAS11118617
    GO:0007213G-protein coupled acetylcholine receptor signaling pathway ISS--
    GO:0007215glutamate receptor signaling pathway ISS--

    Find genes that share ontologies with PLCB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PLCB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLCB1 (see all 1226)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----

    Selected Novoseek inferred chemical compound relationships for PLCB1 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pip2 79.1 19 8872139 (4), 11880496 (4), 9020783 (3), 17981726 (1) (see all 6)
    pl-cs 78.5 3 8081249 (1), 7893368 (1), 11606452 (1)
    inositol 1,4,5 trisphosphate 74.2 10 1341877 (1), 9003025 (1), 12773638 (1), 16885398 (1) (see all 10)
    phosphoinositide 72.3 31 7728419 (3), 11790517 (2), 15554872 (2), 9053741 (2) (see all 17)
    phosphatidylinositol 70.3 62 7589147 (3), 16216883 (3), 1327153 (3), 8897825 (2) (see all 29)
    inositol 55.8 7 1313004 (1), 16216883 (1), 12451591 (1), 1688588 (1) (see all 6)
    gtp 54.3 9 9053741 (1), 10391901 (1), 16216883 (1), 7762157 (1) (see all 8)
    guanosine 5'-o-(3-thiotriphosphate) 50.5 2 9053741 (1), 8415674 (1)
    carbachol 47.5 3 19818737 (1), 9875470 (1), 11377826 (1)
    phospholipid 46.4 10 9020783 (1), 8223634 (1), 8994965 (1), 12578375 (1) (see all 9)



    Find genes that share compounds with PLCB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section


    REFSEQ mRNAs for PLCB1 gene (4 alternative transcripts): 
    NM_015192.3  NM_182734.2  XM_005260681.2  XM_006723555.1  

    Unigene Cluster for PLCB1:

    Phospholipase C, beta 1 (phosphoinositide-specific)
    Hs.431173  [show with all ESTs]
    Unigene Representative Sequence: NM_182734
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378641(uc002wna.3) ENST00000338037(uc002wnb.3) ENST00000378637(uc010gbv.1 uc010zrb.1 uc002wnc.1)
    ENST00000404098(uc002wmz.1) ENST00000475958 ENST00000487210 ENST00000494924(uc002wnd.1)
    ENST00000439627 ENST00000437439
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PLCB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLCB1 (see all 46):
    hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-183* hsa-miR-124 hsa-miR-3658 hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PLCB1
    Predesigned siRNA for gene silencing in human, mouse, rat PLCB1
    Clone
    Products:
         
    OriGene clones in human, mouse for PLCB1 (see all 13)
    OriGene ORF clones in mouse, rat for PLCB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLCB1 (NM_182734)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCB1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PLCB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCB1
      QuantiTect SYBR Green Assays in human, mouse, rat PLCB1
      QuantiFast Probe-based Assays in human, mouse, rat PLCB1

    Additional mRNA sequence: 

    AB011153.3 AJ278313.1 AJ278314.1 AK127693.1 AK299195.1 AK310597.1 AL137267.1 AY004175.1 
    BC069420.1 BC117231.1 

    9 DOTS entries:

    DT.92424266  DT.99933444  DT.95163124  DT.70103970  DT.100667819  DT.100747119  DT.120796192  DT.97838383 
    DT.40310532 

    Selected AceView cDNA sequences (see all 103):

    AL138266 BG623122 AI935790 CK902057 AI637950 F05349 F06554 AK023689 
    NM_182734 BM684706 BM930856 AJ278314 AA854470 AV645592 NM_015192 H88361 
    BX379154 BC069420 BG210746 H88421 AB011153 BG614437 AW088707 BG529189 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PLCB1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                -                                                                           
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36
    SP1:                                            -                                 
    SP2:                                                  -     -                     
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for PLCB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLCB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PLCB1 Expression
    About this image


    PLCB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    PLCB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLCB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.431173
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLCB1: 
              GABA & Glutamate in human mouse rat
              Huntington's Disease in human mouse rat
              Gap Junctions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PLCB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCB1
    QuantiTect SYBR Green Assays in human, mouse, rat PLCB1
    QuantiFast Probe-based Assays in human, mouse, rat PLCB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section


    This gene was present in the common ancestor of animals.

    Orthologs for PLCB1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plcb11 , 5 phospholipase C, beta 11, 5 89.14(n)1
    97.37(a)1
      2 (65.66 cM)5
    187951  NM_001145830.11  NP_001139302.11 
     1347861595 
    chicken
    (Gallus gallus)
    Aves PLCB11 phospholipase C, beta 1 (phosphoinositide-specific) 82.19(n)
    92.06(a)
      427687  XM_425261.4  XP_425261.3 
    lizard
    (Anolis carolinensis)
    Reptilia PLCB16
    phospholipase C, beta 1 (phosphoinositide-specific...
    86(a)
    1 ↔ 1
    1(135261541-135829867)
    zebrafish
    (Danio rerio)
    Actinopterygii PLCB1 (2 of 2)6
    PLCB1 (1 of 2)6
    phospholipase C, beta 1 (phosphoinositide-specific...
    phospholipase C, beta 1 (phosphoinositide-specific...
    72(a)
    64(a)
    1 ↔ many
    1 ↔ many
    17(3432607-3454633) ENSDARG00000090084
    20(55131760-55147092) ENSDARG00000068594
    fruit fly
    (Drosophila melanogaster)
    Insecta Plc21C1 Phospholipase C at 21C 56.68(n)
    55.15(a)
      33204  NM_205882.2  NP_995604.2 


    ENSEMBL Gene Tree for PLCB1 (if available)
    TreeFam Gene Tree for PLCB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for PLCB1 gene
    PLCD42  PLCD12  PLCB22  PLCZ12  PLCH12  PLCB32  PLCD32  PLCH22  
    PLCB42  PLCL22  PLCL12  
    9 SIMAP similar genes for PLCB1 using alignment to 5 protein entries:     PLCB1_HUMAN (see all proteins):
    PLCB2    PLCB3    PLCB4    DKFZp686K101    PLCD1    PLCD4
    PLCZ1    PLCL2    PLCD3

    Find genes that share paralogs with PLCB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Selected SNPs for PLCB1 (see all 15980)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365474
    A breast cancer sample4--see VAR_0365472 A P mis40--------
    rs1476482271,2
    Cuntested18586220(+) AGCCTC/TGCCAG 4 L syn10--------
    rs9324911,2
    C,F,A,H--8058192(-) ACTACG/ATTCTC 2 -- us2k134Minor allele frequency- A:0.28NS EA NA WA CSA 3192
    rs1817965621,2
    --8058266(+) ATAATC/TTATTT 2 -- us2k10--------
    rs9324901,2
    C,F,A,H--8058329(-) tgTGTG/ATGTTT 2 -- us2k1 tfbs39Minor allele frequency- A:0.09NS EA NA CSA WA 760
    rs1480719221,2
    --8058363(+) CTCATC/TAGGTG 2 -- us2k10--------
    rs1861518821,2
    --8058446(+) TGCCTA/GTTCTG 2 -- us2k10--------
    rs1174846351,2
    F--8058570(+) GAATAG/ATATTC 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs124812471,2
    C,F,H--8058631(+) atttgC/Taggct 2 -- us2k1 tfbs37Minor allele frequency- T:0.17NA WA EA 366
    rs730782371,2
    C--8058678(+) CCTGCA/GGACTT 2 -- us2k13Minor allele frequency- G:0.10NA EA 242

    HapMap Linkage Disequilibrium report for PLCB1 (8112824 - 8362824 bp, first 250kb of PLCB1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PLCB1 (see all 58):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722159CNV Deletion23290073
    esv2665461CNV Deletion23128226
    esv2722158CNV Deletion23290073
    esv2722156CNV Deletion23290073
    esv2656531CNV Deletion23128226
    esv2722154CNV Deletion23290073
    esv2742905CNV Deletion23290073
    esv2660358CNV Deletion23128226
    esv2295237CNV Deletion18987734
    esv2722157CNV Deletion23290073

    Human Gene Mutation Database (HGMD): PLCB1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLCB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 607120   
    OMIM disorders: 613722  
    UniProtKB/Swiss-Prot: PLCB1_HUMAN, Q9NQ66
  • Epileptic encephalopathy, early infantile, 12 (EIEE12) [MIM:613722]: A form of epilepsy characterized by
    frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns,
    characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to
    West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and
    hypsarrhythmia on EEG. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 2 diseases for PLCB1:    
    About MalaCards
    epileptic encephalopathy, early infantile, 12    epileptic encephalopathy, early infantile, 2


    Find genes that share disorders with PLCB1           About GenesLikeMe

    9 Novoseek inferred disease relationships for PLCB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 47.9 15 9823310 (4), 7606713 (2), 17022104 (1), 1703925 (1) (see all 6)
    osteosarcoma 14.8 2 8872139 (2)
    leukemia t-cell 11.2 1 1703925 (1)
    tumors 1.33 1 1703925 (1)
    cholera 0 4 16085656 (2), 8389133 (1)
    mood disorders 0 1 11790517 (1)
    glioma 0 2 9053741 (2)
    major depression 0 1 11790517 (1)
    heart failure 0 1 10728414 (1)

    Genetic Association Database (GAD): PLCB1
    Human Genome Epidemiology (HuGE) Navigator: PLCB1 (7 documents)

    Export disorders for PLCB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for PLCB1 gene, integrated from 10 sources (see all 262):
    (articles sorted by number of sources associating them with PLCB1)

    1. Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCbeta1). (PubMed id 11118617)1, 2, 3, 9 Caricasole A.... Terstappen G.C. (Biochim. Biophys. Acta 2000)
    2. Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta 1. (PubMed id 10760467)1, 2, 3, 9 Peruzzi D.... Cocco L. (Biochim. Biophys. Acta 2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Common genetic variation and performance on standardized cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (Eur. J. Hum. Genet. 2010)
    5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    6. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
    7. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    8. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PubMed id 18649358)1, 4 Ng D....Taylor P.R. (Int. J. Cancer 2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23236 HGNC: 15917 AceView: PLCB1 Ensembl:ENSG00000182621 euGenes: HUgn23236
    ECgene: PLCB1 Kegg: 23236 H-InvDB: PLCB1

    (According to HUGE)
    About This Section
    HUGE: KIAA0581

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLCB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLCB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLCB1 gene:
    Search GeneIP for patents involving PLCB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway and/or Taconic Biosciences,
    CRISPR knockouts from OriGene)
    About This Section


     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PLCB1
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for PLCB1 (PLC-beta 1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PLCB1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PLCB1  
     OriGene MassSpec for PLCB1   OriGene clones in human, mouse for PLCB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PLCB1   OriGene Purified Protein for PLCB1  
     OriGene ORF clones in mouse, rat for PLCB1   OriGene CRISPR knockouts for PLCB1
      
     OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling   OriGene Custom Antibody Services for PLCB1  
     OriGene Custom Protein Services for PLCB1  

     
     
     Block miRNA regulation of human, mouse, rat PLCB1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PLCB1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLCB1 Predesigned siRNA for gene silencing in human, mouse, rat PLCB1
     QuantiFast Probe-based Assays in human, mouse, rat PLCB1 QuantiTect SYBR Green Assays in human, mouse, rat PLCB1
     PCR Arrays including human, mouse, rat PLCB1 Search Chromatin IP Primers for PLCB1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLCB1  GeneGlobe Interaction Network for PLCB1
     Regulatory tfbs in PLCB1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PLCB1 GenScript cDNA clones with any tag delivered in your preferred vector for PLCB1
     GenScript Custom Assay Services for PLCB1 GenScript Custom overexpressing Cell Line Services for PLCB1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for PLCB1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PLCB1 antibodies
     PLCB1 proteins
     PLCB1 lysates
     Antibodies for PLCB1
     See all of Abcam's Antibodies, Kits and Proteins for PLCB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PLCB1
      Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLCB1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PLCB1
     SwitchGear Promoter luciferase reporter plasmids for PLCB1
     ThermoFisher Antibodies for PLCB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLCB1
     Browse compounds at ApexBio
     Search Addgene for plasmids for PLCB1
      Search eBioscience for proteins for PLCB1
      Search eBioscience for elisas for PLCB1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PLCB1
     antibodies-online antibodies for PLCB1 (43 products)
     antibodies-online kits for PLCB1 (13 products)
     antibodies-online peptides for PLCB1
     antibodies-online proteins for PLCB1 (2 products)
      GeneTex Antibodies for PLCB1: PLCB1 Antibodies
      Search GeneTex for Proteins for PLCB1
           
    GeneCards Home - Full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015 , 3 Feb 2015 , 31 Mar 2015

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science
    This site does not provide medical advice and is for research use only
    Hot genes      Disease genes      PLCB1 gene at Home site.
    Version: 3.12.396 26 May 2015
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4