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Aliases for PLBD1 Gene

Aliases for PLBD1 Gene

  • Phospholipase B Domain Containing 1 2 3
  • Phospholipase B Domain-Containing Protein 1 4
  • PLB Homolog 1 (Dictyostelium) 2
  • Lamina Ancestor Homolog 1 4
  • LAMA-Like Protein 1 4
  • EC 3.1.1.- 4
  • EC 3.1.1 64

External Ids for PLBD1 Gene

Summaries for PLBD1 Gene

GeneCards Summary for PLBD1 Gene

PLBD1 (Phospholipase B Domain Containing 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is PLBD2.

UniProtKB/Swiss-Prot for PLBD1 Gene

  • In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLBD1 Gene

Genomics for PLBD1 Gene

Genomic Location for PLBD1 Gene

Start:
14,503,661 bp from pter
End:
14,568,349 bp from pter
Size:
64,689 bases
Orientation:
Minus strand

Genomic View for PLBD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLBD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLBD1 Gene

Regulatory Elements for PLBD1 Gene

Proteins for PLBD1 Gene

  • Protein details for PLBD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4A8-PLBL1_HUMAN
    Recommended name:
    Phospholipase B-like 1
    Protein Accession:
    Q6P4A8
    Secondary Accessions:
    • A8K4E9
    • Q9BVV3
    • Q9H625

    Protein attributes for PLBD1 Gene

    Size:
    553 amino acids
    Molecular mass:
    63255 Da
    Quaternary structure:
    • May form a homodimer, each monomer is composed of a chain A and a chain B.
    SequenceCaution:
    • Sequence=AAH00909.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15442.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PLBD1 Gene

Proteomics data for PLBD1 Gene at MOPED

Selected DME Specific Peptides for PLBD1 Gene

Post-translational modifications for PLBD1 Gene

  • The maturation cleavages that produces chains A and B are required to open the putative substrate binding pocket. Both chains A and B remain associated in the mature protein.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn71, Asn308, Asn366, Asn411, and Asn526

Other Protein References for PLBD1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PLBD1 Gene

Protein Domains for PLBD1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PLBL1_HUMAN
Family:
  • Belongs to the phospholipase B-like family.:
    • Q6P4A8
genes like me logo Genes that share domains with PLBD1: view

No data available for Gene Families for PLBD1 Gene

Function for PLBD1 Gene

Molecular function for PLBD1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 7.4. {ECO:0000269 PubMed:19019078};
UniProtKB/Swiss-Prot Function: In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.

Enzyme Numbers (IUBMB) for PLBD1 Gene

Gene Ontology (GO) - Molecular Function for PLBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLBD1: view

Phenotypes for PLBD1 Gene

GenomeRNAi human phenotypes for PLBD1:
genes like me logo Genes that share phenotypes with PLBD1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLBD1 Gene

Localization for PLBD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLBD1 Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLBD1 Gene COMPARTMENTS Subcellular localization image for PLBD1 gene
Compartment Confidence
extracellular 5
cytosol 4
golgi apparatus 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PLBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PLBD1: view

Pathways for PLBD1 Gene

genes like me logo Genes that share pathways with PLBD1: view

Interacting Proteins for PLBD1 Gene

Gene Ontology (GO) - Biological Process for PLBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0016042 lipid catabolic process IEA --
GO:0036149 phosphatidylinositol acyl-chain remodeling TAS --
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with PLBD1: view

Transcripts for PLBD1 Gene

mRNA/cDNA for PLBD1 Gene

Unigene Clusters for PLBD1 Gene

Phospholipase B domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLBD1 Gene

No ASD Table

Relevant External Links for PLBD1 Gene

GeneLoc Exon Structure for
PLBD1
ECgene alternative splicing isoforms for
PLBD1

Expression for PLBD1 Gene

mRNA expression in normal human tissues for PLBD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLBD1 Gene

This gene is overexpressed in Whole Blood (30.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLBD1 Gene

SOURCE GeneReport for Unigene cluster for PLBD1 Gene Hs.131933

mRNA Expression by UniProt/SwissProt for PLBD1 Gene

Q6P4A8-PLBL1_HUMAN
Tissue specificity: Expressed in neutrophils and monocytes.
genes like me logo Genes that share expressions with PLBD1: view

Orthologs for PLBD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLBD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLBD1 36
  • 99.43 (n)
  • 99.24 (a)
PLBD1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLBD1 36
  • 88.13 (n)
  • 85.32 (a)
PLBD1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLBD1 36
  • 89.81 (n)
  • 85.58 (a)
PLBD1 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plbd1 36
  • 80.95 (n)
  • 80.5 (a)
Plbd1 16
Plbd1 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLBD1 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLBD1 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plbd1 36
  • 80.18 (n)
  • 79.15 (a)
chicken
(Gallus gallus)
Aves PLBD1 36
  • 70.84 (n)
  • 70.84 (a)
PLBD1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLBD1 37
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.844 36
zebrafish
(Danio rerio)
Actinopterygii plbd1 36
  • 60.41 (n)
  • 58.89 (a)
plbd1 37
  • 55 (a)
OneToMany
PLBD1 (2 of 2) 37
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta lama 37
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F09B12.3 37
  • 29 (a)
ManyToMany
Y37D8A.2 37
  • 31 (a)
ManyToMany
Y54F10AM.8 37
  • 28 (a)
ManyToMany
Species with no ortholog for PLBD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLBD1 Gene

ENSEMBL:
Gene Tree for PLBD1 (if available)
TreeFam:
Gene Tree for PLBD1 (if available)

Paralogs for PLBD1 Gene

Paralogs for PLBD1 Gene

genes like me logo Genes that share paralogs with PLBD1: view

Variants for PLBD1 Gene

Sequence variations from dbSNP and Humsavar for PLBD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1600 - 14,503,834(+) CTCTG(C/G)CATGC reference, missense
rs747527 -- 14,505,407(+) ATTCC(A/G)CCAAC intron-variant
rs747528 -- 14,506,507(-) TCTCT(C/T)TCCCA intron-variant
rs1344558 -- 14,508,794(+) GAGCa(A/G)cttgt intron-variant
rs1344559 -- 14,509,031(+) ATATG(A/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLBD1 Gene

Variant ID Type Subtype PubMed ID
nsv469119 CNV Gain 19166990
nsv470269 CNV Gain 18288195
nsv618 CNV Loss 18451855

Relevant External Links for PLBD1 Gene

HapMap Linkage Disequilibrium report
PLBD1

Disorders for PLBD1 Gene

No disorders were found for PLBD1 Gene.

No data available for UniProtKB/Swiss-Prot for PLBD1 Gene

Publications for PLBD1 Gene

  1. The identification of a phospholipase B precursor in human neutrophils. (PMID: 19019078) Xu S. … Venge P. (FEBS J. 2009) 2 3 4
  2. Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast. (PMID: 15193148) Morgan C.P. … Cockcroft S. (Biochem. J. 2004) 2 3
  3. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for PLBD1 Gene

Sources for PLBD1 Gene

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