Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLBD1 Gene

protein-coding   GIFtS: 45
GCID: GC12M014657

Phospholipase B Domain Containing 1

  Search for PLBD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase B Domain Containing 11 2     Phospholipase B-Like 12
Lamina Ancestor Homolog 12 3     PLB Homolog 12
Phospholipase B Domain-Containing Protein 12 3     Putative Phospholipase B-Like 12
LAMA-Like Protein 12 3     EC 3.1.1.-3
PLB Homolog 1 (Dictyostelium)1     EC 3.1.18

External Ids:    HGNC: 262151   Entrez Gene: 798872   Ensembl: ENSG000001213167   UniProtKB: Q6P4A83   

Export aliases for PLBD1 gene to outside databases

Previous GC identifers: GC12M014548 GC12M014425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PLBD1 Gene: 
PLBD1 (phospholipase B domain containing 1) is a protein-coding gene. Among its related super-pathways are Acyl chain remodelling of PI and Glycerophospholipid biosynthesis. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is PLBD2.

UniProtKB/Swiss-Prot: PLBL1_HUMAN, Q6P4A8
Function: Phospholipase acting on various phospholipids including phosphatidylcholine, phosphatidylinositol,
phosphatidylethanolamine and lysophospholipids. May have a role in the defense against invading microorganisms
and in the generation of lipid mediators of inflammation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLBD1 gene promoter:
         c-Fos   USF1   AP-1   SREBP-1c   USF2   USF-1:USF-2   SREBP-1b   SREBP-1a   USF-1   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PLBD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLBD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p13.1

PLBD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLBD1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M014657:  view genomic region     (about GC identifiers)

Start:
14,656,595 bp from pter      End:
14,721,283 bp from pter
Size:
64,689 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLBL1_HUMAN, Q6P4A8 (See protein sequence)
Recommended Name: Phospholipase B-like 1 precursor  
Size: 553 amino acids; 63255 Da
Subunit: May exist as a non-covalently associated tetramer of two 22 kDa and two 42 kDa chains
Subcellular location: Cytoplasmic granule. Secreted
Sequence caution: Sequence=AAH00909.2; Type=Erroneous initiation; Sequence=BAB15442.1; Type=Erroneous initiation;
Secondary accessions: A8K4E9 Q9BVV3 Q9H625

Explore the universe of human proteins at neXtProt for PLBD1: NX_Q6P4A8

Explore proteomics data for PLBD1 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytic processing leading to a 22 kDa N-terminal and a 42 kDa C-terminal fragment appears necessary for
    activity, which seems to derive from the 42 kDa chain
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P4A8

  • 4/5 DME Specific Peptides for PLBD1 (Q6P4A8) (see all 5)
     GYWPSYN  NSGTYNN  LSNEIIMF  TNLYPQLI 

    PLBD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLBD1 Protein Expression
    REFSEQ proteins: NP_079105.4  
    ENSEMBL proteins: 
     ENSP00000240617   ENSP00000441278   ENSP00000438367  
    Reactome Protein details: Q6P4A8
    Human Recombinant Protein Products for PLBD1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PLBD1
    OriGene Protein Over-expression Lysate for PLBD1
    OriGene MassSpec for PLBD1 
    OriGene Custom Protein Services for PLBD1
    GenScript Custom Purified and Recombinant Proteins Services for PLBD1
    Novus Biologicals PLBD1 Protein
    Novus Biologicals PLBD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PLBD1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005829cytosol TAS--

    PLBD1 for ontologies           About GeneDecksing



    PLBD1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PLBD1
    GenScript Custom Superior Antibodies Services for PLBD1
    Novus Biologicals PLBD1 Antibodies
    Abcam antibodies for PLBD1
    Cloud-Clone Corp. Antibodies for PLBD1 
    Search ThermoFisher Antibodies for PLBD1
    Search LSBio for Antibodies for PLBD1 

    Assay Products for PLBD1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PLBD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PLBD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PLBD1 
    Cloud-Clone Corp. CLIAs for PLBD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007000 PLipase_B-like

    Graphical View of Domain Structure for InterPro Entry Q6P4A8

    ProtoNet protein and cluster: Q6P4A8

    UniProtKB/Swiss-Prot: PLBL1_HUMAN, Q6P4A8
    Similarity: Belongs to the phospholipase B-like family


    PLBD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLBL1_HUMAN, Q6P4A8
    Function: Phospholipase acting on various phospholipids including phosphatidylcholine, phosphatidylinositol,
    phosphatidylethanolamine and lysophospholipids. May have a role in the defense against invading microorganisms
    and in the generation of lipid mediators of inflammation
    Biophysicochemical properties: pH dependence: Optimum pH is 7.4;

         Enzyme Numbers (IUBMB): EC 3.1.12 EC 3.1.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    PLBD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PLBD1:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLBD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLBD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLBD1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLBD1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLBD1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PLBD1:
    hsa-miR-9
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLBD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLBD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLBD1
    Sirion Biotech Customized adenovirus for overexpression of PLBD1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PLBD1 (see all 7)
    OriGene ORF clones in mouse, rat for PLBD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLBD1 (NM_024829)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLBD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLBD1
    Sirion Biotech Customized lentivirus for stable overexpression of PLBD1 
                         Customized lentivirus expression plasmids for stable overexpression of PLBD1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLBD1
    Search LifeMap BioReagents cell lines for PLBD1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLBD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLBD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Acyl chain remodelling of PE
    Acyl chain remodelling of PE0.85
    Acyl chain remodelling of PI0.65
    Acyl chain remodelling of PC0.85
    Hydrolysis of LPC0.33
    2Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Phospholipid metabolism0.64
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for PLBD1 (see all 8)
        Acyl chain remodelling of PE
    Metabolism
    Acyl chain remodelling of PC
    Hydrolysis of LPC
    Phospholipid metabolism



    PLBD1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLBD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for PLBD1 (ENSP000002406174) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPCPD1ENSP000003683054STRING: ENSP00000368305
    LPCAT1ENSP000002834154STRING: ENSP00000283415
    LPCAT2ENSP000002621344STRING: ENSP00000262134
    LPCAT4ENSP000003173004STRING: ENSP00000317300
    MBOAT1ENSP000003249444STRING: ENSP00000324944
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0016042lipid catabolic process IEA--
    GO:0036149phosphatidylinositol acyl-chain remodeling TAS--
    GO:0036151phosphatidylcholine acyl-chain remodeling TAS--
    GO:0036152phosphatidylethanolamine acyl-chain remodeling TAS--

    PLBD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLBD1 (PLBL1)

    Search CenterWatch for drugs/clinical trials and news about PLBD1 / PLBL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLBD1 gene: 
    NM_024829.5  

    Unigene Cluster for PLBD1:

    Phospholipase B domain containing 1
    Hs.131933  [show with all ESTs]
    Unigene Representative Sequence: NM_024829
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240617(uc001rcc.1) ENST00000541800 ENST00000541618 ENST00000540572

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLBD1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PLBD1:
    hsa-miR-9
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLBD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLBD1
    Clone
    Products:
         
    OriGene clones in human, mouse for PLBD1 (see all 7)
    OriGene ORF clones in mouse, rat for PLBD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLBD1 (NM_024829)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLBD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLBD1
    Sirion Biotech Customized lentivirus for stable overexpression of PLBD1 
                         Customized lentivirus expression plasmids for stable overexpression of PLBD1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PLBD1
    OriGene qSTAR qPCR primer pairs in human, mouse for PLBD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLBD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLBD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLBD1

    Additional mRNA sequence: 

    AK026315.1 AK225458.1 AK290914.1 BC000909.2 BC063561.1 

    7 DOTS entries:

    DT.215545  DT.121150828  DT.75101935  DT.91734534  DT.121150822  DT.75102752  DT.91817248 

    24/194 AceView cDNA sequences (see all 194):

    BG110795 BX116782 CR602008 BQ101253 BG542885 AA669072 BM142639 AW169974 
    BM263066 BU736309 AA252038 CR598292 BU581527 AW629861 BG572884 AA931082 
    CR621086 CR615954 AA298290 BX643808 AA513409 AI439533 AI474721 AA862799 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLBD1 expression in normal human tissues (normalized intensities)      PLBD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACCAATTT
    PLBD1 Expression
    About this image


    PLBD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone Marrow CD33+ Cells   
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Placenta (Extraembryonic Tissues)

    See PLBD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLBD1

    SOURCE GeneReport for Unigene cluster: Hs.131933

    UniProtKB/Swiss-Prot: PLBL1_HUMAN, Q6P4A8
    Tissue specificity: Expressed in neutrophils and monocytes

        SABiosciences Custom PCR Arrays for PLBD1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PLBD1
    OriGene qSTAR qPCR primer pairs in human, mouse for PLBD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLBD1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLBD1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLBD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLBD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PLBD1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plbd11 , 5 phospholipase B domain containing 11, 5 80.38(n)1
    79.7(a)1
      6 (66.59 cM)5
    668571  NM_025806.21  NP_080082.11 
     1366120705 
    chicken
    (Gallus gallus)
    Aves PLBD11 phospholipase B domain containing 1 70.11(n)
    69.73(a)
      417967  XM_416206.3  XP_416206.2 
    lizard
    (Anolis carolinensis)
    Reptilia PLBD16
    phospholipase B domain containing 1
    67(a)
    1 ↔ 1
    GL343714.1(81017-108756)
    zebrafish
    (Danio rerio)
    Actinopterygii plbd11 phospholipase B domain containing 1 60.41(n)
    58.89(a)
      569736  NM_001130791.1  NP_001124263.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lama6
    lamina ancestor
    15(a)
    1 → many
    3L(5336719-5349023)
    worm
    (Caenorhabditis elegans)
    Secernentea Y37D8A.26
    F09B12.36
    (see all 3)
    Putative phospholipase B-like 2
    (see all 3)
    30(a)
    29(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(12820141-12825651)
    X(15095335-15097954)


    ENSEMBL Gene Tree for PLBD1 (if available)
    TreeFam Gene Tree for PLBD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLBD1 gene
    PLBD22  

    PLBD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1265 SNPs in PLBD1 are shown (see all 1265)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898658771,2
    --14656124(+) TGTATC/TGTATG 1 -- int10--------
    rs1829788121,2
    --14656340(+) CACTCG/TTCTCA 1 -- int10--------
    rs782049031,2
    C--14656507(+) TTAGTG/ATTATT 1 -- int12Minor allele frequency- A:0.21CSA WA 120
    rs38383511,2
    C--14656611(+) GACAA-/ATTAA 
            
    TATAT
    2 -- ut311Minor allele frequency- ATTAA:0.00NA 2
    rs1136733311,2
    C,F--14656732(+) AATTGG/ATTTCA 2 /P /S mis13Minor allele frequency- A:0.00CSA NA EU 5871
    rs16001,2,4
    C,F,O,A,H--14656768(+) CTCTGG/CCATGC 2 /P /A mis122Minor allele frequency- C:0.48MN NA EA NS WA CSA EU 8601
    rs1417676191,2
    C,F--14656783(+) ATGTAG/CAGTTT 2 /L /V mis11Minor allele frequency- C:0.00NA 4552
    rs1454133421,2
    C,F--14656797(+) TGAAAC/TGGTCC 2 H R mis11Minor allele frequency- T:0.01NA 4552
    rs1381535981,2
    C--14656911(+) GAGGAC/GATTTT 1 -- int10--------
    rs746224391,2
    C,F--14656931(+) TCGTTC/GAGCAA 1 -- int13Minor allele frequency- G:0.06WA NA EA 358

    HapMap Linkage Disequilibrium report for PLBD1 (14656595 - 14721283 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLBD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv618CNV Loss18451855
    nsv470269CNV Gain18288195
    nsv469119CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PLBD1
    DNA2.0 Custom Variant and Variant Library Synthesis for PLBD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLBD1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with PLBD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The identification of a phospholipase B precursor in human neutrophils. (PubMed id 19019078)1, 2, 3 Xu S....Venge P. (2009)
    2. Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast. (PubMed id 15193148)1, 3 Morgan C.P....Cockcroft S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Genome-wide association study of d-amphetamine respons e in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). (PubMed id 22952603)1 Hart A.B....Palmer A.A. (2012)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. ErbB2-associated changes in the lysosomal proteome. (PubMed id 21674799)1 Nylandsted J....Jaattela M. (2011)
    8. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    9. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79887 HGNC: 26215 AceView: FLJ22662 Ensembl:ENSG00000121316 euGenes: HUgn79887
    ECgene: PLBD1 H-InvDB: PLBD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLBD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLBD1 gene:
    Search GeneIP for patents involving PLBD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PLBD1  
     OriGene qPCR primer pairs and template standards for PLBD1   OriGene Protein Over-expression Lysate for PLBD1  
     OriGene MassSpec something-or-other for PLBD1   OriGene clones in human, mouse for PLBD1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PLBD1   OriGene Purified Protein for PLBD1  
     OriGene ORF clones in mouse, rat for PLBD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PLBD1   OriGene Custom Protein Services for PLBD1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLBD1
     QIAGEN SeqTarget long-range PCR primers for resequencing PLBD1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLBD1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLBD1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLBD1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLBD1
     GenScript Custom Purified and Recombinant Proteins Services for PLBD1 GenScript cDNA clones with any tag delivered in your preferred vector for PLBD1
     GenScript Custom Assay Services for PLBD1 GenScript Custom Superior Antibodies Services for PLBD1
     GenScript Custom overexpressing Cell Line Services for PLBD1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PLBD1 promoter
     Search Chromatin IP Primers for PLBD1
     RT2 qPCR Primer Assay in human, mouse, rat PLBD1
     Search GNC Networks for PLBD1
     SABiosciences Custom PCR Arrays for PLBD1
     Search Tocris compounds for PLBD1 (PLBL1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PLBD1 antibodies
     PLBD1 proteins
     PLBD1 lysates
     Antibodies for PLBD1
     See all of Abcam's Antibodies, Kits and Proteins for PLBD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PLBD1
     Antibodies for PLBD1
     ELISAs for PLBD1
     CLIAs for PLBD1
     Search LifeMap BioReagents cell lines for PLBD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLBD1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PLBD1
     Browse SwitchGear Promoter luciferase reporter plasmids for PLBD1
     Search ThermoFisher Antibodies for PLBD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLBD1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PLBD1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLBD1
    Customized:
     lentivirus for stable overexpression of PLBD1
     lentivirus expression plasmids for stable overexpression of PLBD1
     adenovirus for overexpression of PLBD1
     Search LSBio for Antibodies for PLBD1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PLBD1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4