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Aliases for PLBD1 Gene

Aliases for PLBD1 Gene

  • Phospholipase B Domain Containing 1 2 3 5
  • Phospholipase B Domain-Containing Protein 1 4
  • PLB Homolog 1 (Dictyostelium) 2
  • Lamina Ancestor Homolog 1 4
  • LAMA-Like Protein 1 4
  • EC 3.1.1.- 4
  • EC 3.1.1 63

External Ids for PLBD1 Gene

Previous GeneCards Identifiers for PLBD1 Gene

  • GC12M014548
  • GC12M014657
  • GC12M014425

Summaries for PLBD1 Gene

GeneCards Summary for PLBD1 Gene

PLBD1 (Phospholipase B Domain Containing 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is PLBD2.

UniProtKB/Swiss-Prot for PLBD1 Gene

  • In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLBD1 Gene

Genomics for PLBD1 Gene

Regulatory Elements for PLBD1 Gene

Promoters for PLBD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLBD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLBD1 Gene

Chromosome:
12
Start:
14,503,661 bp from pter
End:
14,568,349 bp from pter
Size:
64,689 bases
Orientation:
Minus strand

Genomic View for PLBD1 Gene

Genes around PLBD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLBD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLBD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLBD1 Gene

Proteins for PLBD1 Gene

  • Protein details for PLBD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4A8-PLBL1_HUMAN
    Recommended name:
    Phospholipase B-like 1
    Protein Accession:
    Q6P4A8
    Secondary Accessions:
    • A8K4E9
    • Q9BVV3
    • Q9H625

    Protein attributes for PLBD1 Gene

    Size:
    553 amino acids
    Molecular mass:
    63255 Da
    Quaternary structure:
    • May form a homodimer, each monomer is composed of a chain A and a chain B.
    SequenceCaution:
    • Sequence=AAH00909.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15442.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PLBD1 Gene

Proteomics data for PLBD1 Gene at MOPED

Selected DME Specific Peptides for PLBD1 Gene

Post-translational modifications for PLBD1 Gene

  • The maturation cleavages that produces chains A and B are required to open the putative substrate binding pocket. Both chains A and B remain associated in the mature protein.
  • Glycosylation at Asn 71, Asn 308, Asn 366, Asn 411, and Asn 526
  • Modification sites at PhosphoSitePlus

Other Protein References for PLBD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PLBD1 Gene

Protein Domains for PLBD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLBD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P4A8

UniProtKB/Swiss-Prot:

PLBL1_HUMAN :
  • Belongs to the phospholipase B-like family.
Family:
  • Belongs to the phospholipase B-like family.
genes like me logo Genes that share domains with PLBD1: view

No data available for Gene Families for PLBD1 Gene

Function for PLBD1 Gene

Molecular function for PLBD1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.4. {ECO:0000269 PubMed:19019078};
UniProtKB/Swiss-Prot Function:
In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.

Enzyme Numbers (IUBMB) for PLBD1 Gene

Phenotypes for PLBD1 Gene

genes like me logo Genes that share phenotypes with PLBD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLBD1 Gene

Localization for PLBD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLBD1 Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLBD1 Gene COMPARTMENTS Subcellular localization image for PLBD1 gene
Compartment Confidence
extracellular 5
cytosol 4
lysosome 4
vacuole 4
golgi apparatus 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for PLBD1 Gene

Pathways & Interactions for PLBD1 Gene

genes like me logo Genes that share pathways with PLBD1: view

Interacting Proteins for PLBD1 Gene

Gene Ontology (GO) - Biological Process for PLBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036149 phosphatidylinositol acyl-chain remodeling TAS --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PLBD1: view

No data available for SIGNOR curated interactions for PLBD1 Gene

Drugs & Compounds for PLBD1 Gene

No Compound Related Data Available

Transcripts for PLBD1 Gene

Unigene Clusters for PLBD1 Gene

Phospholipase B domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLBD1 Gene

No ASD Table

Relevant External Links for PLBD1 Gene

GeneLoc Exon Structure for
PLBD1
ECgene alternative splicing isoforms for
PLBD1

Expression for PLBD1 Gene

mRNA expression in normal human tissues for PLBD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLBD1 Gene

This gene is overexpressed in Whole Blood (x30.8).

Protein differential expression in normal tissues from HIPED for PLBD1 Gene

This gene is overexpressed in Neutrophil (24.0), Monocytes (11.5), and Spleen (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLBD1 Gene



SOURCE GeneReport for Unigene cluster for PLBD1 Gene Hs.131933

mRNA Expression by UniProt/SwissProt for PLBD1 Gene

Q6P4A8-PLBL1_HUMAN
Tissue specificity: Expressed in neutrophils and monocytes.
genes like me logo Genes that share expression patterns with PLBD1: view

Protein tissue co-expression partners for PLBD1 Gene

Primer Products

In Situ Assay Products

Orthologs for PLBD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLBD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLBD1 36
  • 99 (a)
OneToOne
PLBD1 35
  • 99.43 (n)
  • 99.24 (a)
cow
(Bos Taurus)
Mammalia PLBD1 36
  • 83 (a)
OneToOne
PLBD1 35
  • 88.13 (n)
  • 85.32 (a)
dog
(Canis familiaris)
Mammalia PLBD1 35
  • 89.81 (n)
  • 85.58 (a)
PLBD1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plbd1 16
Plbd1 35
  • 80.95 (n)
  • 80.5 (a)
Plbd1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLBD1 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLBD1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plbd1 35
  • 80.18 (n)
  • 79.15 (a)
chicken
(Gallus gallus)
Aves PLBD1 35
  • 70.84 (n)
  • 70.84 (a)
PLBD1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLBD1 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.844 35
zebrafish
(Danio rerio)
Actinopterygii plbd1 36
  • 55 (a)
OneToMany
PLBD1 (2 of 2) 36
  • 54 (a)
OneToMany
plbd1 35
  • 60.41 (n)
  • 58.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta lama 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F09B12.3 36
  • 29 (a)
ManyToMany
Y37D8A.2 36
  • 31 (a)
ManyToMany
Y54F10AM.8 36
  • 28 (a)
ManyToMany
Species with no ortholog for PLBD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLBD1 Gene

ENSEMBL:
Gene Tree for PLBD1 (if available)
TreeFam:
Gene Tree for PLBD1 (if available)

Paralogs for PLBD1 Gene

Paralogs for PLBD1 Gene

genes like me logo Genes that share paralogs with PLBD1: view

Variants for PLBD1 Gene

Sequence variations from dbSNP and Humsavar for PLBD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_032072 -
rs2287541 - 14,511,316(+) GCTCC(A/G)CAATG reference, missense
rs1600 - 14,503,834(+) CTCTG(C/G)CATGC reference, missense
rs1344558 -- 14,508,794(+) GAGCa(A/G)cttgt intron-variant
rs1344559 -- 14,509,031(+) ATATG(A/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLBD1 Gene

Variant ID Type Subtype PubMed ID
nsv469119 CNV Gain 19166990
nsv470269 CNV Gain 18288195
nsv618 CNV Loss 18451855

Variation tolerance for PLBD1 Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.99; 80.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLBD1 Gene

HapMap Linkage Disequilibrium report
PLBD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLBD1 Gene

Disorders for PLBD1 Gene

Relevant External Links for PLBD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLBD1

No disorders were found for PLBD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLBD1 Gene

Publications for PLBD1 Gene

  1. The identification of a phospholipase B precursor in human neutrophils. (PMID: 19019078) Xu S. … Venge P. (FEBS J. 2009) 2 3 4 67
  2. Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast. (PMID: 15193148) Morgan C.P. … Cockcroft S. (Biochem. J. 2004) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. (PMID: 25645918) Thaysen-Andersen M. … Packer N.H. (J. Biol. Chem. 2015) 3
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3

Products for PLBD1 Gene

Sources for PLBD1 Gene

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