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PLAUR Gene

protein-coding   GIFtS: 67
GCID: GC19M044150

Plasminogen Activator, Urokinase Receptor

  See PLAUR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Plasminogen Activator, Urokinase Receptor1 2     URKR2 5
Urokinase Plasminogen Activator Surface Receptor1 2     CD872
Urokinase-Type Plasminogen Activator (UPA) Receptor1 2     U-Plasminogen Activator Receptor Form 22
Monocyte Activation Antigen Mo32 3     MO33
U-PAR2 3     CD87 Antigen3
UPAR2 3     uPAR3

External Ids:    HGNC: 90531   Entrez Gene: 53292   Ensembl: ENSG000000114227   OMIM: 1733915   UniProtKB: Q034053   

Export aliases for PLAUR gene to outside databases

Previous GC identifers: GC19M044796 GC19M044542 GC19M048826 GC19M048844 GC19M048842 GC19M040580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLAUR Gene:
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting
plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen
activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms
of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The
protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a
glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its
carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in
multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational
cleavage reactions that have not yet been fully defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for PLAUR Gene:
PLAUR (plasminogen activator, urokinase receptor) is a protein-coding gene. Diseases associated with PLAUR include paranasal sinus disease, and aids dementia complex. GO annotations related to this gene include urokinase plasminogen activator receptor activity and enzyme binding.

UniProtKB/Swiss-Prot: UPAR_HUMAN, Q03405
Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin
formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to
negative-feedback regulation by U-PA which cleaves it into an inactive form

Gene Wiki entry for PLAUR (Urokinase receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLAUR gene promoter:
         STAT1   Sp1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PLAUR promoter sequence
   Search Chromatin IP Primers for PLAUR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLAUR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13

PLAUR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLAUR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044150:  view genomic region     (about GC identifiers)

Start:
44,150,247 bp from pter      End:
44,174,699 bp from pter
Size:
24,453 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UPAR_HUMAN, Q03405 (See protein sequence)
Recommended Name: Urokinase plasminogen activator surface receptor precursor  
Size: 335 amino acids; 36978 Da
Subunit: Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with
SORL1
Selected PDB 3D structures from and Proteopedia for PLAUR (see all 7):
1YWH (3D)        2FD6 (3D)        2I9B (3D)        3BT1 (3D)        3BT2 (3D)        3U73 (3D)    
Secondary accessions: A8K409 Q12876 Q15845 Q16887 Q6IB52 Q9BWT0 Q9NYC8 Q9UD69 Q9UEA6 Q9UM92
Q9UMV0
Alternative splicing: 3 isoforms:  Q03405-1   Q03405-2   Q03405-3   (Ref.3 (no nucleotide entry) sequence is in conflict in position: 158:V->I)

Explore the universe of human proteins at neXtProt for PLAUR: NX_Q03405

Explore proteomics data for PLAUR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn74, Asn184, Asn194, Asn222, Asn255

  • See PLAUR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001005376.1  NP_001005377.1  NP_002650.1  

    ENSEMBL proteins: 
     ENSP00000342049   ENSP00000470050   ENSP00000471881   ENSP00000339328   ENSP00000221264  
     ENSP00000473055   ENSP00000471525   ENSP00000470029   ENSP00000471307   ENSP00000471241  
     ENSP00000472511   ENSP00000468863  
    Reactome Protein details: Q03405

    PLAUR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PLAUR (uPAR)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for PLAUR
    OriGene Protein Over-expression Lysate for PLAUR
    OriGene MassSpec for PLAUR
    OriGene Custom Protein Services for PLAUR
    GenScript Custom Purified and Recombinant Proteins Services for PLAUR
    Novus Biologicals PLAUR Lysate
    Sino Biological Recombinant Protein for PLAUR
    Sino Biological Cell Lysate for PLAUR
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PLAUR 

     
    antibodies-online proteins for PLAUR (23 products) 

     
    antibodies-online peptides for PLAUR

    PLAUR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PLAUR (uPAR)
    Cell Signaling Technology (CST) Antibodies for PLAUR  (uPAR)
    OriGene Antibodies for PLAUR
    OriGene Custom Antibody Services for PLAUR
    Novus Biologicals PLAUR Antibodies
    Abcam antibodies for PLAUR
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PLAUR
    antibodies-online antibodies for PLAUR (64 products) 

    PLAUR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PLAUR
    R&D Systems ELISAs for PLAUR (uPAR)         (see all)
    GenScript Custom Assay Services for PLAUR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PLAUR 
    antibodies-online kits for PLAUR (39 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    3 InterPro protein domains:
     IPR018363 CD59_antigen_CS
     IPR016054 LY6_UPA_recep-like
     IPR001526 LY6_UPAR

    Graphical View of Domain Structure for InterPro Entry Q03405

    ProtoNet protein and cluster: Q03405

    2 Blocks protein domains:
    IPB001526 CD59 antigen
    IPB003631 Urokinase plasminogen activator surface receptor


    UniProtKB/Swiss-Prot: UPAR_HUMAN, Q03405
    Similarity: Contains 3 UPAR/Ly6 domains


    Find genes that share domains with PLAUR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UPAR_HUMAN, Q03405
    Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin
    formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to
    negative-feedback regulation by U-PA which cleaves it into an inactive form

         Genatlas biochemistry entry for PLAUR:
    plasminogen activator urokinase receptor,significantly diminished in diffuse type gastric carcinoma

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ----
    GO:0004872receptor activity NAS1689240
    GO:0005515protein binding IPI11290596
    GO:0008270zinc ion binding ----
    GO:0019899enzyme binding IPI14688365
         
    Find genes that share ontologies with PLAUR           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for PLAUR:
     Decreased G3BP1 protein expres  G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel 
     Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Plaur):
     behavior/neurological  cardiovascular system  cellular  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  muscle  nervous system 
     renal/urinary system  respiratory system 

    Find genes that share phenotypes with PLAUR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PLAUR: Plaurtm1Jld Plaurtm1Mlg

       genOway: Develop your customized and physiologically relevant rodent model for PLAUR

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLAUR:
    hsa-mir-16-5p (MIRT031606), hsa-mir-155-5p (MIRT020661), hsa-mir-204-5p (MIRT005839)

    Block miRNA regulation of human, mouse, rat PLAUR using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PLAUR:
    hsa-miR-3163 hsa-miR-4283 hsa-miR-544b hsa-miR-377 hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLAUR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLAUR
    Predesigned siRNA for gene silencing in human, mouse, rat PLAUR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLAUR

    Clone
    Products:
         
    OriGene clones in human, mouse for PLAUR (see all 18)
    OriGene ORF clones in mouse, rat for PLAUR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PLAUR (NM_002659)
    Sino Biological Human cDNA Clone for PLAUR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLAUR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAUR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLAUR
    Browse ESI BIO Cell Lines and PureStem Progenitors for PLAUR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAUR

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10025 VA6-13081) for PLAUR 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UPAR_HUMAN, Q03405: Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor
    UPAR_HUMAN, Q03405: Isoform 2: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    extracellular4
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus ----
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with PLAUR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLAUR About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    2Post-translational modification- synthesis of GPI-anchored proteins
    Post-translational modification- synthesis of GPI-anchored proteins0.76
    Attachment of GPI anchor to uPAR0.00
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    4Apoptotic Pathways in Synovial Fibroblasts
    Glioma Invasiveness0.64
    5Integrin Pathway
    UPA-UPAR Pathway0.56


    Find genes that share SuperPaths with PLAUR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLAUR
        Glioma Invasiveness
    UPA-UPAR Pathway
    WNT Signaling

    1 Cell Signaling Technology (CST) Pathway for PLAUR
        Adhesion

    3 GeneGo (Thomson Reuters) Pathways for PLAUR
        Development VEGF signaling via VEGFR2 - generic cascades
    Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling

    5 BioSystems Pathways for PLAUR
        Complement and Coagulation Cascades
    amb2 Integrin signaling
    FGF signaling pathway
    Arf6 downstream pathway
    Validated transcriptional targets of AP1 family members Fra1 and Fra2


    2 Reactome Pathways for PLAUR
        Attachment of GPI anchor to uPAR
    Dissolution of Fibrin Clot


    2 Kegg Pathways  (Kegg details for PLAUR):
        Complement and coagulation cascades
    Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLAUR: 
              WNT Signaling Targets in human mouse rat
              Wound Healing in human mouse rat
              Tumor Metastasis in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLAUR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLAUR (Q034052, 3 ENSP000003393284) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFN2P350802, 3MINT-64050 I2D: score=5 
    SURF2Q155272, 3, ENSP000003610324MINT-64051 I2D: score=4 STRING: ENSP00000361032
    TYK2P295973, ENSP000002648184I2D: score=4 STRING: ENSP00000264818
    IL6STP401893, ENSP000003387994I2D: score=3 STRING: ENSP00000338799
    LRP1Q079543, ENSP000002430774I2D: score=3 STRING: ENSP00000243077
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006928cellular component movement NAS1689240
    GO:0006935chemotaxis TAS10749881
    GO:0007165signal transduction TAS10749881

    Find genes that share ontologies with PLAUR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLAUR (UPAR)

    5 DrugBank Compounds for PLAUR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--14688365 12817472 17327908 12615913 14679304 14720519
    Tenecteplaset- PA (see all 4)191588-94-0target--12210068 11447759 15231724
    Alteplaset-PA (see all 4)105857-23-6target--17139284 17016423
    Anistreplaset- PA (see all 4)81669-57-0target--17139284 17016423
    Reteplaset- PA (see all 4)133652-38-7target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for PLAUR gene (see all 103)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 77.5 40 10599442 (5), 15302576 (2), 8187097 (2), 10591631 (1) (see all 25)
    kininogen 73.6 18 14764580 (2), 11414365 (1), 12944405 (1), 15044324 (1) (see all 13)
    serine 63.4 81 12790317 (2), 18508598 (2), 9191470 (1), 9198168 (1) (see all 62)
    aprotinin 51.5 11 11422178 (2), 7962113 (1), 8601593 (1), 11169951 (1) (see all 7)
    glycolipid 49 23 1325906 (3), 7615819 (1), 8392005 (1), 7548000 (1) (see all 10)
    p-amino benzamidine 47.9 3 9872599 (1), 11804183 (1)
    mannose 6-phosphate 47.8 17 12665524 (2), 18220730 (1), 15085180 (1), 9566979 (1) (see all 9)
    pimonidazole 46.3 4 14729600 (1), 15781654 (1), 11912164 (1)
    vegf 44.1 102 16810742 (7), 12708473 (5), 7730348 (4), 16088182 (4) (see all 35)
    epsilon aminocaproic acid 39 3 7962113 (1), 11169951 (1), 10090848 (1)



    Find genes that share compounds with PLAUR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLAUR gene (3 alternative transcripts): 
    NM_001005376.2  NM_001005377.2  NM_002659.3  

    Unigene Cluster for PLAUR:

    Plasminogen activator, urokinase receptor
    Hs.466871  [show with all ESTs]
    Unigene Representative Sequence: BM554045
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339082(uc002oxd.2) ENST00000593447 ENST00000601723 ENST00000340093(uc002oxf.2)
    ENST00000221264(uc002oxg.2) ENST00000595038 ENST00000594364 ENST00000593714
    ENST00000599892 ENST00000597107 ENST00000602141 ENST00000593939 ENST00000593396
    ENST00000598875 ENST00000599546 ENST00000601876
    miRNA
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    Block miRNA regulation of human, mouse, rat PLAUR using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PLAUR:
    hsa-miR-3163 hsa-miR-4283 hsa-miR-544b hsa-miR-377 hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLAUR 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PLAUR
    Predesigned siRNA for gene silencing in human, mouse, rat PLAUR
    Clone
    Products:
         
    OriGene clones in human, mouse for PLAUR (see all 18)
    OriGene ORF clones in mouse, rat for PLAUR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PLAUR (NM_002659)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLAUR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAUR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PLAUR
    OriGene qSTAR qPCR primer pairs in human, mouse for PLAUR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLAUR
      QuantiTect SYBR Green Assays in human, mouse, rat PLAUR
      QuantiFast Probe-based Assays in human, mouse, rat PLAUR
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10025 VA6-13081) for PLAUR 

    Additional mRNA sequence: 

    AF257789.1 AK290774.1 AY029180.1 BC002788.2 CR456952.1 M83246.1 U08839.1 U09347.1 
    X51675.1 X74039.1 

    14 DOTS entries:

    DT.454959  DT.99968496  DT.100797888  DT.97803353  DT.75101350  DT.95276935  DT.99930521  DT.121442407 
    DT.40228927  DT.91940708  DT.95257090  DT.75148085  DT.92431704  DT.95276939 

    Selected AceView cDNA sequences (see all 289):

    CA489863 BC002788 BM914922 BU687998 BI793096 AI570820 CK821016 BP354862 
    BU608773 AA337688 AJ712415 CB148651 CA308579 AI924885 CA307585 CD743102 
    AL710258 BQ647008 CD370071 U09347 AW351505 CD367492 T29574 CD672247 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLAUR (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
    SP1:                                -     -     -     -     -                       -     -                                                               
    SP2:                                -     -     -     -     -                       -     -                                   -     -     -               
    SP3:                                -     -     -     -     -                       -     -                 -                                             
    SP4:                                -     -     -     -     -                       -     -                       -     -                                 
    SP5:                                -     -     -     -     -           -     -     -     -                                   -     -     -               


    ECgene alternative splicing isoforms for PLAUR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PLAUR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCACATTG
    PLAUR Expression
    About this image


    PLAUR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Fibroblasts (Uncategorized)
     
     Gall Bladder (Hepatobiliary System)
    PLAUR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLAUR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466871

    UniProtKB/Swiss-Prot: UPAR_HUMAN, Q03405
    Tissue specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the
    brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLAUR: 
              WNT Signaling Targets in human mouse rat
              Wound Healing in human mouse rat
              Tumor Metastasis in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PLAUR gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plaur1 , 5 plasminogen activator, urokinase receptor1, 5 69.78(n)1
    63.23(a)1
      7 (10.92 cM)5
    187931  NM_011113.31  NP_035243.11 
     244625005 
    lizard
    (Anolis carolinensis)
    Reptilia PLAUR6
    plasminogen activator, urokinase receptor
    31(a)
    1 ↔ 1
    LGf(961232-973882)


    ENSEMBL Gene Tree for PLAUR (if available)
    TreeFam Gene Tree for PLAUR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PLAUR (see all 759)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402037481,2
    C--40584363(+) AAAGA-/AAAG  
            
    AAAGA
    3 -- int10--------
    rs2009264621,2
    --40584412(+) GGAAA-/GAAG  
            
    GAAGG
    3 -- int10--------
    rs42519181,2
    C,F--40585745(-) CGCCAG/CGCTAG 3 -- int12Minor allele frequency- C:0.01NS 86
    rs42519021,2
    C,F--40588565(-) ATTTTT/AAAAAC 3 -- int16Minor allele frequency- A:0.02NS NA 230
    rs719528791,2
    C--40596148(+) TTTTC-/T/T   
      TTTTTT
    TTTTT
    3 -- int10--------
    rs58281741,2
    C--44150963(+) TTTTTG/TGGGGA 1 -- int1 trp30--------
    rs42519301,2
    C,F--44152159(-) CATTCC/TGAACC 1 -- int12Minor allele frequency- T:0.01NS 90
    rs602206961,2
    C--44154171(+) TTTTT-/TGAGAT 3 -- int11Minor allele frequency- T:0.00CSA 2
    rs1139202061,2
    C--44155235(+) TATTTT/AATTTT 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs42519151,2
    C,F--44155607(-) TTTGTC/TTCAAA 3 -- int14Minor allele frequency- T:0.02NS NA EA 334

    HapMap Linkage Disequilibrium report for PLAUR (44150247 - 44174699 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PLAUR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2445332CNV Insertion19546169
    nsv833839CNV Loss17160897

    Human Gene Mutation Database (HGMD): PLAUR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLAUR
    DNA2.0 Custom Variant and Variant Library Synthesis for PLAUR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173391    OMIM disorders: --

    9 diseases for PLAUR:    
    About MalaCards
    paranasal sinus disease    aids dementia complex    hemoglobinuria    pemphigus foliaceus
    pemphigus    frontal lobe epilepsy    malaria    colon cancer
    pancreatic cancer


    Find genes that share disorders with PLAUR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PLAUR gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 73.6 353 19050704 (5), 18399120 (5), 17264329 (4), 11912164 (4) (see all 99)
    tumors 66.8 802 15172186 (7), 17549400 (6), 9102229 (6), 10090848 (6) (see all 99)
    cancer 66.3 398 14595671 (5), 9137501 (4), 11223863 (3), 15279614 (3) (see all 99)
    ureter carcinoma 63.3 2 15191676 (1), 14981816 (1)
    breast cancer 55.1 180 14527916 (5), 10934293 (5), 12967140 (5), 7768629 (4) (see all 86)
    glioblastoma 54.5 72 7747809 (5), 18819934 (5), 9219733 (4), 11234878 (3) (see all 23)
    colon cancer 48.5 65 14977859 (6), 9191056 (4), 15004225 (3), 19782465 (3) (see all 23)
    ovarian cancer 47.7 56 9581823 (3), 17891393 (3), 14563447 (3), 19395996 (3) (see all 24)
    cancer invasiveness 47 5 14977859 (2), 11079728 (1), 9794194 (1)
    paroxysmal hemoglobinuria nocturnal 45.1 12 9114600 (2), 1325906 (1), 15182554 (1), 18954937 (1) (see all 6)

    Genetic Association Database (GAD): PLAUR
    Human Genome Epidemiology (HuGE) Navigator: PLAUR (19 documents)

    Export disorders for PLAUR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLAUR gene, integrated from 10 sources (see all 1309):
    (articles sorted by number of sources associating them with PLAUR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator. (PubMed id 1316922)1, 2, 9 Min H.Y.... Liu D.Y. (J. Immunol. 1992)
    2. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. (PubMed id 19443020)1, 4, 9 Barton S.J....Sayers I. (J. Allergy Clin. Immunol. 2009)
    3. PLAUR polymorphisms and lung function in UK smokers. (PubMed id 19878584)1, 4, 9 Stewart C.E....Sayers I. (BMC Med. Genet. 2009)
    4. Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide. (PubMed id 15861141)1, 2, 9 Llinas P.... Menez A. (EMBO J. 2005)
    5. Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G. (PubMed id 14688365)1, 7, 9 Beaufort N....Pidard D. (J. Immunol. 2004)
    6. Cell-surface acceleration of urokinase-catalyzed receptor cleavage. (PubMed id 9030717)1, 2, 9 Hoeyer-Hansen G.... Danoe K. (Eur. J. Biochem. 1997)
    7. The structure of the urokinase-type plasminogen activator receptor gene. (PubMed id 8049431)1, 2, 9 Casey J.R.... Rosse W.F. (Blood 1994)
    8. An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator. (PubMed id 8392005)1, 2, 9 Pyke C.... Danoe K. (FEBS Lett. 1993)
    9. Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid- anchored membrane proteins. (PubMed id 8394346)1, 2, 9 Ploug M.... Danoe K. (J. Biol. Chem. 1993)
    10. Association of polymorphisms in the genes of the urokinase plasminogen activation system with susceptibility to and severity of non-small cell lung cancer. (PubMed id 20937265)1, 4 Shih C.M....Lee Y.L. ( international journal of clinical chemistry 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5329 HGNC: 9053 AceView: PLAUR Ensembl:ENSG00000011422 euGenes: HUgn5329
    ECgene: PLAUR Kegg: 5329 H-InvDB: PLAUR

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLAUR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLAUR Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/plaur/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLAUR gene:
    Search GeneIP for patents involving PLAUR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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