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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLAUR Gene

protein-coding   GIFtS: 67
GCID: GC19M044150

Plasminogen Activator, Urokinase Receptor

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Plasminogen Activator, Urokinase Receptor1 2     URKR2 5
Urokinase Plasminogen Activator Surface Receptor1 2     CD872
Urokinase-Type Plasminogen Activator (UPA) Receptor1 2     U-Plasminogen Activator Receptor Form 22
Monocyte Activation Antigen Mo32 3     MO33
U-PAR2 3     CD87 Antigen3
UPAR2 3     uPAR3

External Ids:    HGNC: 90531   Entrez Gene: 53292   Ensembl: ENSG000000114227   OMIM: 1733915   UniProtKB: Q034053   

Export aliases for PLAUR gene to outside databases

Previous GC identifers: GC19M044796 GC19M044542 GC19M048826 GC19M048844 GC19M048842 GC19M040580


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLAUR Gene:
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting
plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen
activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms
of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The
protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a
glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its
carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in
multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational
cleavage reactions that have not yet been fully defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for PLAUR Gene: 
PLAUR (plasminogen activator, urokinase receptor) is a protein-coding gene. Diseases associated with PLAUR include paranasal sinus disease, and aids dementia complex, and among its related super-pathways are Complement and Coagulation Cascades and Post-translational protein modification. GO annotations related to this gene include enzyme binding and U-plasminogen activator receptor activity.

UniProtKB/Swiss-Prot: UPAR_HUMAN, Q03405
Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin
formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to
negative-feedback regulation by U-PA which cleaves it into an inactive form

Gene Wiki entry for PLAUR (Urokinase receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLAUR gene promoter:
         STAT1   Sp1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PLAUR promoter sequence
   Search SABiosciences Chromatin IP Primers for PLAUR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLAUR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13

PLAUR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLAUR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044150:  view genomic region     (about GC identifiers)

Start:
44,150,247 bp from pter      End:
44,174,699 bp from pter
Size:
24,453 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UPAR_HUMAN, Q03405 (See protein sequence)
Recommended Name: Urokinase plasminogen activator surface receptor precursor  
Size: 335 amino acids; 36978 Da
Subunit: Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2
Subcellular location: Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor
Subcellular location: Isoform 2: Secreted (Probable)
6/7 PDB 3D structures from and Proteopedia for PLAUR (see all 7):
1YWH (3D)        2FD6 (3D)        2I9B (3D)        3BT1 (3D)        3BT2 (3D)        3U73 (3D)    
Secondary accessions: A8K409 Q12876 Q15845 Q16887 Q6IB52 Q9BWT0 Q9NYC8 Q9UD69 Q9UEA6 Q9UM92
Q9UMV0
Alternative splicing: 3 isoforms:  Q03405-1   Q03405-2   Q03405-3   (Ref.3 (no nucleotide entry) sequence is in conflict in position: 158:V->I)

Explore the universe of human proteins at neXtProt for PLAUR: NX_Q03405

Explore proteomics data for PLAUR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q03405

  • PLAUR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLAUR Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001005376.1  NP_001005377.1  NP_002650.1  

    ENSEMBL proteins: 
     ENSP00000342049   ENSP00000470050   ENSP00000471881   ENSP00000339328   ENSP00000221264  
     ENSP00000473055   ENSP00000471525   ENSP00000470029   ENSP00000471307   ENSP00000471241  
     ENSP00000472511   ENSP00000468863  
    Reactome Protein details: Q03405
    Human Recombinant Protein Products for PLAUR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PLAUR (uPAR)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PLAUR
    OriGene Protein Over-expression Lysate for PLAUR
    OriGene MassSpec for PLAUR 
    OriGene Custom Protein Services for PLAUR
    GenScript Custom Purified and Recombinant Proteins Services for PLAUR
    Novus Biologicals PLAUR Lysate
    Sino Biological Recombinant Protein for PLAUR
    Sino Biological Cell Lysate for PLAUR 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus ----
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane TAS--

    PLAUR for ontologies           About GeneDecksing



    PLAUR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PLAUR (uPAR)
    Cell Signaling Technology (CST) Antibodies for PLAUR  (uPAR)
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    GenScript Custom Superior Antibodies Services for PLAUR
    Novus Biologicals PLAUR Antibodies
    Abcam antibodies for PLAUR
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PLAUR
    Search LSBio for Antibodies for PLAUR 

    Assay Products for PLAUR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PLAUR
    R&D Systems ELISAs for PLAUR (uPAR)         (see all)
    GenScript Custom Assay Services for PLAUR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    3 InterPro protein domains:
     IPR018363 CD59_antigen_CS
     IPR016054 LY6_UPA_recep-like
     IPR001526 LY6_UPAR

    Graphical View of Domain Structure for InterPro Entry Q03405

    ProtoNet protein and cluster: Q03405

    2 Blocks protein domains:
    IPB001526 CD59 antigen
    IPB003631 Urokinase plasminogen activator surface receptor


    UniProtKB/Swiss-Prot: UPAR_HUMAN, Q03405
    Similarity: Contains 3 UPAR/Ly6 domains


    PLAUR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UPAR_HUMAN, Q03405
    Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin
    formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to
    negative-feedback regulation by U-PA which cleaves it into an inactive form

         Genatlas biochemistry entry for PLAUR:
    plasminogen activator urokinase receptor,significantly diminished in diffuse type gastric carcinoma

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ----
    GO:0004872receptor activity NAS1689240
    GO:0005515protein binding IPI11290596
    GO:0008270zinc ion binding ----
    GO:0019899enzyme binding IPI14688365
         
    PLAUR for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for PLAUR:
     Decreased G3BP1 protein expres  G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel 
     Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Plaur):
     behavior/neurological  cardiovascular system  cellular  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  muscle  nervous system 
     renal/urinary system  respiratory system 

    PLAUR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PLAUR: Plaurtm1Jld Plaurtm1Mlg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLAUR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLAUR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLAUR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLAUR 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLAUR:
    hsa-mir-204 (MIRT005839)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLAUR
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PLAUR:
    hsa-miR-3163 hsa-miR-4283 hsa-miR-544b hsa-miR-377 hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLAUR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLAUR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLAUR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLAUR
    Sirion Biotech Customized adenovirus for overexpression of PLAUR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PLAUR (see all 20)
    OriGene ORF clones in mouse, rat for PLAUR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PLAUR (NM_002659)
    Sino Biological Human cDNA Clone for PLAUR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLAUR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAUR
    Sirion Biotech Customized lentivirus for stable overexpression of PLAUR 
                         Customized lentivirus expression plasmids for stable overexpression of PLAUR 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PLAUR
    Search LifeMap BioReagents cell lines for PLAUR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAUR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLAUR About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational modification: synthesis of GPI-anchored proteins0.79
    4Apoptotic Pathways in Synovial Fibroblasts
    Glioma Invasiveness0.64
    5Integrin Pathway
    UPA-UPAR Pathway0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PLAUR
        Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLAUR
        Glioma Invasiveness
    UPA-UPAR Pathway
    WNT Signaling

    1 Cell Signaling Technology (CST) Pathway for PLAUR
        Adhesion

    3 GeneGo (Thomson Reuters) Pathways for PLAUR
        Development VEGF signaling via VEGFR2 - generic cascades
    Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling

    5 BioSystems Pathways for PLAUR
        Complement and Coagulation Cascades
    Arf6 downstream pathway
    amb2 Integrin signaling
    FGF signaling pathway
    Validated transcriptional targets of AP1 family members Fra1 and Fra2


    5/6        Reactome Pathways for PLAUR (see all 6)
        Hemostasis
    Attachment of GPI anchor to uPAR
    Dissolution of Fibrin Clot
    Metabolism of proteins
    Post-translational modification: synthesis of GPI-anchored proteins


    2         Kegg Pathways  (Kegg details for PLAUR):
        Complement and coagulation cascades
    Proteoglycans in cancer


    PLAUR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLAUR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/69 Interacting proteins for PLAUR (Q034052, 3 ENSP000003393284) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFN2P350802, 3MINT-64050 I2D: score=5 
    SURF2Q155272, 3, ENSP000003610324MINT-64051 I2D: score=4 STRING: ENSP00000361032
    TYK2P295973, ENSP000002648184I2D: score=4 STRING: ENSP00000264818
    IL6STP401893, ENSP000003387994I2D: score=3 STRING: ENSP00000338799
    LRP1Q079543, ENSP000002430774I2D: score=3 STRING: ENSP00000243077
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006928cellular component movement NAS1689240
    GO:0006935chemotaxis TAS10749881
    GO:0007165signal transduction TAS10749881

    PLAUR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLAUR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLAUR (UPAR)

    5 DrugBank Compounds for PLAUR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--14688365 12817472 17327908 12615913 14679304 14720519
    Tenecteplaset- PA (see all 4)191588-94-0target--12210068 11447759 15231724
    Alteplaset-PA (see all 4)105857-23-6target--17139284 17016423
    Anistreplaset- PA (see all 4)81669-57-0target--17139284 17016423
    Reteplaset- PA (see all 4)133652-38-7target--17139284 17016423

    10/103 Novoseek inferred chemical compound relationships for PLAUR gene (see all 103)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 77.5 40 10599442 (5), 15302576 (2), 8187097 (2), 10591631 (1) (see all 25)
    kininogen 73.6 18 14764580 (2), 11414365 (1), 12944405 (1), 15044324 (1) (see all 13)
    serine 63.4 81 12790317 (2), 18508598 (2), 9191470 (1), 9198168 (1) (see all 62)
    aprotinin 51.5 11 11422178 (2), 7962113 (1), 8601593 (1), 11169951 (1) (see all 7)
    glycolipid 49 23 1325906 (3), 7615819 (1), 8392005 (1), 7548000 (1) (see all 10)
    p-amino benzamidine 47.9 3 9872599 (1), 11804183 (1)
    mannose 6-phosphate 47.8 17 12665524 (2), 18220730 (1), 15085180 (1), 9566979 (1) (see all 9)
    pimonidazole 46.3 4 14729600 (1), 15781654 (1), 11912164 (1)
    vegf 44.1 102 16810742 (7), 12708473 (5), 7730348 (4), 16088182 (4) (see all 35)
    epsilon aminocaproic acid 39 3 7962113 (1), 11169951 (1), 10090848 (1)

    Search CenterWatch for drugs/clinical trials and news about PLAUR / UPAR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLAUR gene (3 alternative transcripts): 
    NM_001005376.2  NM_001005377.2  NM_002659.3  

    Unigene Cluster for PLAUR:

    Plasminogen activator, urokinase receptor
    Hs.466871  [show with all ESTs]
    Unigene Representative Sequence: BM554045
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339082(uc002oxd.2) ENST00000593447 ENST00000601723 ENST00000340093(uc002oxf.2)
    ENST00000221264(uc002oxg.2) ENST00000595038 ENST00000594364 ENST00000593714
    ENST00000599892 ENST00000597107 ENST00000602141 ENST00000593939 ENST00000593396
    ENST00000598875 ENST00000599546 ENST00000601876

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PLAUR:
    hsa-miR-3163 hsa-miR-4283 hsa-miR-544b hsa-miR-377 hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLAUR 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector (see all 3): PLAUR (NM_002659)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLAUR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAUR
    Sirion Biotech Customized lentivirus for stable overexpression of PLAUR 
                         Customized lentivirus expression plasmids for stable overexpression of PLAUR 
    Primer
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    OriGene qPCR primer pairs and template standards for PLAUR
    OriGene qSTAR qPCR primer pairs in human, mouse for PLAUR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLAUR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLAUR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLAUR

    Additional mRNA sequence: 

    AF257789.1 AK290774.1 AY029180.1 BC002788.2 CR456952.1 M83246.1 U08839.1 U09347.1 
    X51675.1 X74039.1 

    14 DOTS entries:

    DT.454959  DT.99968496  DT.100797888  DT.97803353  DT.75101350  DT.95276935  DT.99930521  DT.121442407 
    DT.40228927  DT.91940708  DT.95257090  DT.75148085  DT.92431704  DT.95276939 

    24/289 AceView cDNA sequences (see all 289):

    CA488827 AA379455 CA307585 CD672247 CD370071 CA748755 AJ712415 CR611518 
    CA307240 CD365963 AI924885 CD370232 AW351505 BU626444 CD368421 CD367492 
    BM767461 AL710258 U09347 BM914922 CF126247 CA306527 CD370941 CF126152 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PLAUR (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
    SP1:                                -     -     -     -     -                       -     -                                                               
    SP2:                                -     -     -     -     -                       -     -                                   -     -     -               
    SP3:                                -     -     -     -     -                       -     -                 -                                             
    SP4:                                -     -     -     -     -                       -     -                       -     -                                 
    SP5:                                -     -     -     -     -           -     -     -     -                                   -     -     -               


    ECgene alternative splicing isoforms for PLAUR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLAUR expression in normal human tissues (normalized intensities)      PLAUR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCACATTG
    PLAUR Expression
    About this image


    PLAUR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             monocytes   
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts

    See PLAUR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLAUR

    SOURCE GeneReport for Unigene cluster: Hs.466871

    UniProtKB/Swiss-Prot: UPAR_HUMAN, Q03405
    Tissue specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the
    brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including PLAUR: 
              WNT Signaling Targets in human mouse rat
              Wound Healing in human mouse rat
              Tumor Metastasis in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PLAUR gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plaur1 , 5 plasminogen activator, urokinase receptor1, 5 69.75(n)1
    63.27(a)1
      7 (10.92 cM)5
    187931  NM_011113.31  NP_035243.11 
     244625005 
    lizard
    (Anolis carolinensis)
    Reptilia PLAUR6
    --
    Uncharacterized protein
    32(a)
    24(a)
    1 ↔ 1
    possible ortholog
    LGf(961232-973882)
    LGf(938940-944965)


    ENSEMBL Gene Tree for PLAUR (if available)
    TreeFam Gene Tree for PLAUR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/759 SNPs in PLAUR are shown (see all 759)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402037481,2
    C--40584363(+) AAAGA-/AAAG  
            
    AAAGA
    3 -- int10--------
    rs2009264621,2
    --40584412(+) GGAAA-/GAAG  
            
    GAAGG
    3 -- int10--------
    rs42519181,2
    C,F--40585745(-) CGCCAG/CGCTAG 3 -- int12Minor allele frequency- C:0.01NS 86
    rs42519021,2
    C,F--40588565(-) ATTTTT/AAAAAC 3 -- int16Minor allele frequency- A:0.02NS NA 230
    rs719528791,2
    C--40596148(+) TTTTC-/T/T   
      TTTTTT
    TTTTT
    3 -- int10--------
    rs58281741,2
    C--44150963(+) TTTTTG/TGGGGA 1 -- int1 trp30--------
    rs42519301,2
    C,F--44152159(-) CATTCC/TGAACC 1 -- int12Minor allele frequency- T:0.01NS 90
    rs602206961,2
    C--44154171(+) TTTTT-/TGAGAT 3 -- int11Minor allele frequency- T:0.00CSA 2
    rs1139202061,2
    C--44155235(+) TATTTT/AATTTT 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs42519151,2
    C,F--44155607(-) TTTGTC/TTCAAA 3 -- int14Minor allele frequency- T:0.02NS NA EA 334

    HapMap Linkage Disequilibrium report for PLAUR (44150247 - 44174699 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PLAUR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2445332CNV Insertion19546169
    nsv833839CNV Loss17160897


    Human Gene Mutation Database (HGMD): PLAUR
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PLAUR
    DNA2.0 Custom Variant and Variant Library Synthesis for PLAUR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 173391    OMIM disorders: --

    20/136 diseases for PLAUR (see all 136):    About MalaCards
    paranasal sinus disease    aids dementia complex    pemphigus    paroxysmal nocturnal hemoglobinuria
    pemphigus foliaceus    hemoglobinuria    melioidosis    central nervous system disease
    congenital heart block    pemphigus vulgaris    nervous system disease    giant cell tumor
    prostate disease    glioblastoma    bladder carcinoma    ductal carcinoma in situ
    anaplastic astrocytoma    oral cancer    cerebral malaria    diphtheria


    PLAUR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for PLAUR gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 73.6 353 19050704 (5), 18399120 (5), 17264329 (4), 11912164 (4) (see all 99)
    tumors 66.8 802 15172186 (7), 17549400 (6), 9102229 (6), 10090848 (6) (see all 99)
    cancer 66.3 398 14595671 (5), 9137501 (4), 11223863 (3), 15279614 (3) (see all 99)
    ureter carcinoma 63.3 2 15191676 (1), 14981816 (1)
    breast cancer 55.1 180 14527916 (5), 10934293 (5), 12967140 (5), 7768629 (4) (see all 86)
    glioblastoma 54.5 72 7747809 (5), 18819934 (5), 9219733 (4), 11234878 (3) (see all 23)
    colon cancer 48.5 65 14977859 (6), 9191056 (4), 15004225 (3), 19782465 (3) (see all 23)
    ovarian cancer 47.7 56 9581823 (3), 17891393 (3), 14563447 (3), 19395996 (3) (see all 24)
    cancer invasiveness 47 5 14977859 (2), 11079728 (1), 9794194 (1)
    paroxysmal hemoglobinuria nocturnal 45.1 12 9114600 (2), 1325906 (1), 15182554 (1), 18954937 (1) (see all 6)

    Genetic Association Database (GAD): PLAUR
    Human Genome Epidemiology (HuGE) Navigator: PLAUR (19 documents)

    Export disorders for PLAUR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLAUR gene, integrated from 9 sources (see all 1297):
    (articles sorted by number of sources associating them with PLAUR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator. (PubMed id 1316922)1, 2, 9 Min H.Y.... Liu D.Y. (1992)
    2. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. (PubMed id 19443020)1, 4, 9 Barton S.J....Sayers I. (2009)
    3. PLAUR polymorphisms and lung function in UK smokers. (PubMed id 19878584)1, 4, 9 Stewart C.E....Sayers I. (2009)
    4. Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide. (PubMed id 15861141)1, 2, 9 Llinas P.... Menez A. (2005)
    5. Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G. (PubMed id 14688365)1, 7, 9 Beaufort N....Pidard D. (2004)
    6. Cell-surface acceleration of urokinase-catalyzed receptor cleavage. (PubMed id 9030717)1, 2, 9 Hoeyer-Hansen G.... Danoe K. (1997)
    7. The structure of the urokinase-type plasminogen activator receptor gene. (PubMed id 8049431)1, 2, 9 Casey J.R.... Rosse W.F. (1994)
    8. An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator. (PubMed id 8392005)1, 2, 9 Pyke C.... Danoe K. (1993)
    9. Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid- anchored membrane proteins. (PubMed id 8394346)1, 2, 9 Ploug M.... Danoe K. (1993)
    10. Association of polymorphisms in the genes of the urok inase plasminogen activation system with susceptibility to and severity of non- small cell lung cancer. (PubMed id 20937265)1, 4 Shih C.M....Lee Y.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5329 HGNC: 9053 AceView: PLAUR Ensembl:ENSG00000011422 euGenes: HUgn5329
    ECgene: PLAUR Kegg: 5329 H-InvDB: PLAUR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLAUR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLAUR Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/plaur/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLAUR gene:
    Search GeneIP for patents involving PLAUR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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