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Aliases for PLAUR Gene

Aliases for PLAUR Gene

  • Plasminogen Activator, Urokinase Receptor 2 3
  • Urokinase-Type Plasminogen Activator (UPA) Receptor 2 3
  • Urokinase Plasminogen Activator Surface Receptor 2 3
  • Monocyte Activation Antigen Mo3 3 4
  • U-PAR 3 4
  • URKR 3 6
  • UPAR 3 4
  • U-Plasminogen Activator Receptor Form 2 3
  • CD87 Antigen 4
  • CD87 3
  • MO3 4

External Ids for PLAUR Gene

Previous GeneCards Identifiers for PLAUR Gene

  • GC19M044796
  • GC19M044542
  • GC19M048826
  • GC19M048844
  • GC19M048842
  • GC19M044150
  • GC19M040580

Summaries for PLAUR Gene

Entrez Gene Summary for PLAUR Gene

  • This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLAUR Gene

PLAUR (Plasminogen Activator, Urokinase Receptor) is a Protein Coding gene. Diseases associated with PLAUR include paranasal sinus disease and aids dementia complex. Among its related pathways are Proteoglycans in cancer and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include enzyme binding and urokinase plasminogen activator receptor activity.

UniProtKB/Swiss-Prot for PLAUR Gene

  • Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form

Gene Wiki entry for PLAUR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAUR Gene

Genomics for PLAUR Gene

Regulatory Elements for PLAUR Gene

Transcription factor binding sites by QIAGEN in the PLAUR gene promoter:

Genomic Location for PLAUR Gene

Start:
43,646,095 bp from pter
End:
43,670,547 bp from pter
Size:
24,453 bases
Orientation:
Minus strand

Genomic View for PLAUR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLAUR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAUR Gene

Proteins for PLAUR Gene

  • Protein details for PLAUR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03405-UPAR_HUMAN
    Recommended name:
    Urokinase plasminogen activator surface receptor
    Protein Accession:
    Q03405
    Secondary Accessions:
    • A8K409
    • Q12876
    • Q15845
    • Q16887
    • Q6IB52
    • Q9BWT0
    • Q9NYC8
    • Q9UD69
    • Q9UEA6
    • Q9UM92
    • Q9UMV0

    Protein attributes for PLAUR Gene

    Size:
    335 amino acids
    Molecular mass:
    D Da
    Quaternary structure:
    • Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with SORL1. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.

    Three dimensional structures from OCA and Proteopedia for PLAUR Gene

    Alternative splice isoforms for PLAUR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLAUR Gene

Proteomics data for PLAUR Gene at MOPED

Post-translational modifications for PLAUR Gene

  • Glycosylation at Asn74, Asn184, Asn194, Asn222, and Asn255
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLAUR Gene

Domains for PLAUR Gene

Gene Families for PLAUR Gene

HGNC:
  • CD :CD molecules

Graphical View of Domain Structure for InterPro Entry

Q03405

UniProtKB/Swiss-Prot:

UPAR_HUMAN :
  • Q03405
Domain:
  • Contains 3 UPAR/Ly6 domains.
genes like me logo Genes that share domains with PLAUR: view

Function for PLAUR Gene

Molecular function for PLAUR Gene

GENATLAS Biochemistry: plasminogen activator urokinase receptor,significantly diminished in diffuse type gastric carcinoma
UniProtKB/Swiss-Prot Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form

Gene Ontology (GO) - Molecular Function for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity --
GO:0004872 receptor activity NAS 1689240
GO:0005102 receptor binding IPI 12665524
GO:0005515 protein binding IPI 11290596
GO:0008270 zinc ion binding --
genes like me logo Genes that share ontologies with PLAUR: view
genes like me logo Genes that share phenotypes with PLAUR: view

Animal Models for PLAUR Gene

MGI Knock Outs for PLAUR:

miRNA for PLAUR Gene

miRTarBase miRNAs that target PLAUR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PLAUR Gene

Localization for PLAUR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAUR Gene

Cell membrane. Cell projection, invadopodium membrane. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269 PubMed:12376466}.
Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLAUR Gene COMPARTMENTS Subcellular localization image for PLAUR gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 4
lysosome 1

Gene Ontology (GO) - Cellular Components for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with PLAUR: view

Pathways for PLAUR Gene

genes like me logo Genes that share pathways with PLAUR: view

Gene Ontology (GO) - Biological Process for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 22984561
GO:0006355 regulation of transcription, DNA-templated --
GO:0006501 C-terminal protein lipidation TAS --
GO:0006928 movement of cell or subcellular component NAS 1689240
GO:0006935 chemotaxis TAS 10749881
genes like me logo Genes that share ontologies with PLAUR: view

Compounds for PLAUR Gene

(5) Drugbank Compounds for PLAUR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alteplase
  • t-PA
105857-23-6 target
Anistreplase
  • t- PA
81669-57-0 target
Reteplase
  • t- PA
133652-38-7 target
Tenecteplase
  • t- PA
191588-94-0 target
Urokinase
  • U-plasminogen activator
9039-53-6 target

(103) Novoseek inferred chemical compound relationships for PLAUR Gene

Compound -log(P) Hits PubMed IDs
matrigel 77.5 31
kininogen 73.6 14
serine 63.4 64
aprotinin 51.5 8
glycolipid 49 12
genes like me logo Genes that share compounds with PLAUR: view

Transcripts for PLAUR Gene

Unigene Clusters for PLAUR Gene

Plasminogen activator, urokinase receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLAUR Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - -
SP7: - -
SP8: - - -
SP9: - - - - -
SP10:
SP11:

Relevant External Links for PLAUR Gene

GeneLoc Exon Structure for
PLAUR
ECgene alternative splicing isoforms for
PLAUR

Expression for PLAUR Gene

mRNA expression in normal human tissues for PLAUR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAUR Gene

This gene is overexpressed in Whole Blood (22.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLAUR Gene

SOURCE GeneReport for Unigene cluster for PLAUR Gene Hs.466871

mRNA Expression by UniProt/SwissProt for PLAUR Gene

Q03405-UPAR_HUMAN
Tissue specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain
genes like me logo Genes that share expressions with PLAUR: view

Orthologs for PLAUR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAUR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLAUR 35
  • 99.3 (n)
  • 99.1 (a)
PLAUR 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLAUR 35
  • 75.73 (n)
  • 61.25 (a)
PLAUR 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLAUR 35
  • 80.67 (n)
  • 71.16 (a)
PLAUR 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plaur 35
  • 69.78 (n)
  • 63.23 (a)
Plaur 16
Plaur 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLAUR 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plaur 35
  • 70.97 (n)
  • 62.9 (a)
lizard
(Anolis carolinensis)
Reptilia PLAUR 36
  • 31 (a)
OneToOne
Species with no ortholog for PLAUR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLAUR Gene

ENSEMBL:
Gene Tree for PLAUR (if available)
TreeFam:
Gene Tree for PLAUR (if available)

Paralogs for PLAUR Gene

No data available for Paralogs for PLAUR Gene

Variants for PLAUR Gene

Sequence variations from dbSNP and Humsavar for PLAUR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2687 -- 43,648,832(-) TCCCt(C/T)ggctc intron-variant, utr-variant-3-prime
rs4760 - 43,648,948(-) CAGCC(C/T)CACCA intron-variant, missense, reference
rs344781 -- 43,670,636(+) CTTCC(C/T)GCTGT upstream-variant-2KB
rs344782 -- 43,668,738(+) TCAAG(A/C)GTCTA intron-variant, upstream-variant-2KB
rs344783 -- 43,668,036(+) AGGTC(C/T)TTCTC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PLAUR Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV Loss 17160897
esv2445332 CNV Insertion 19546169

Relevant External Links for PLAUR Gene

HapMap Linkage Disequilibrium report
PLAUR
Human Gene Mutation Database (HGMD)
PLAUR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAUR Gene

Disorders for PLAUR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (12) Diseases for PLAUR Gene including...

Search for PLAUR Gene in MalaCards »

(97) Novoseek inferred disease relationships for PLAUR Gene

Disease -log(P) Hits PubMed IDs
metastasis 73.6 174
tumors 66.8 286
cancer 66.3 167
ureter carcinoma 63.3 2
breast cancer 55.1 142

Relevant External Links for PLAUR

Genetic Association Database (GAD)
PLAUR
Human Genome Epidemiology (HuGE) Navigator
PLAUR
genes like me logo Genes that share disorders with PLAUR: view

No data available for UniProtKB/Swiss-Prot for PLAUR Gene

Publications for PLAUR Gene

  1. cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator. (PMID: 1316922) Min H.Y. … Liu D.Y. (J. Immunol. 1992) 3 4 23
  2. An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator. (PMID: 8392005) Pyke C. … Danoe K. (FEBS Lett. 1993) 3 4 23
  3. Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid- anchored membrane proteins. (PMID: 8394346) Ploug M. … Danoe K. (J. Biol. Chem. 1993) 3 4 23
  4. Cell-surface acceleration of urokinase-catalyzed receptor cleavage. (PMID: 9030717) Hoeyer-Hansen G. … Danoe K. (Eur. J. Biochem. 1997) 3 4 23
  5. The structure of the urokinase-type plasminogen activator receptor gene. (PMID: 8049431) Casey J.R. … Rosse W.F. (Blood 1994) 3 4 23

Products for PLAUR Gene

Sources for PLAUR Gene

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