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Aliases for PLAUR Gene

Aliases for PLAUR Gene

  • Plasminogen Activator, Urokinase Receptor 2 3 5
  • Urokinase-Type Plasminogen Activator (UPA) Receptor 2 3
  • Urokinase Plasminogen Activator Surface Receptor 2 3
  • Monocyte Activation Antigen Mo3 3 4
  • U-PAR 3 4
  • UPAR 3 4
  • U-Plasminogen Activator Receptor Form 2 3
  • CD87 Antigen 4
  • CD87 3
  • URKR 3
  • MO3 4

External Ids for PLAUR Gene

Previous GeneCards Identifiers for PLAUR Gene

  • GC19M044796
  • GC19M044542
  • GC19M048826
  • GC19M048844
  • GC19M048842
  • GC19M044150
  • GC19M040580

Summaries for PLAUR Gene

Entrez Gene Summary for PLAUR Gene

  • This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLAUR Gene

PLAUR (Plasminogen Activator, Urokinase Receptor) is a Protein Coding gene. Diseases associated with PLAUR include Ureter Cancer and Perforated Corneal Ulcer. Among its related pathways are Immune System and Adhesion. GO annotations related to this gene include receptor binding and receptor activity.

UniProtKB/Swiss-Prot for PLAUR Gene

  • Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Gene Wiki entry for PLAUR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAUR Gene

Genomics for PLAUR Gene

Regulatory Elements for PLAUR Gene

Enhancers for PLAUR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F043673 0.9 FANTOM5 Ensembl ENCODE 50.5 -4.3 -4337 3.0 ATF1 PKNOX1 ZNF133 KLF17 YBX1 ZNF48 ZNF2 ZNF121 ZNF366 SCRT2 PLAUR ZNF45 ZNF180 ZNF284 ZNF224 ZNF234 ZNF155 SMG9 CD177 KCNN4
GH19F043683 1.5 FANTOM5 Ensembl 49.7 -12.8 -12755 0.6 ATF1 PKNOX1 ESRRA BACH1 ZNF316 GATA3 GATA2 NFE2 MAFK NFE2L2 PLAUR SMG9 CEACAM19 KCNN4 IRGQ ZNF222 TEX101 LOC105372412
GH19F043762 1.4 FANTOM5 Ensembl ENCODE 40.2 -95.4 -95431 6.6 HDGF PKNOX1 WRNIP1 SIN3A ZNF2 ZNF121 GLIS2 ZNF143 ZNF207 KLF7 PLAUR ZNF180 ZNF45 SMG9 ZNF155 ZNF234 XRCC1 LOC105372414 CEACAMP10 ENSG00000267614
GH19F043696 0.6 FANTOM5 35.4 -25.9 -25917 0.2 HDAC1 PKNOX1 ATF1 HLF CEBPB JUND ATF3 HDAC2 IKZF1 PBX2 PLAUR ZNF428 CADM4 SMG9 KCNN4 ZNF222 IRGQ PIR53869 IRGC
GH19F043744 1.5 FANTOM5 Ensembl ENCODE 31 -74.6 -74568 1.6 HDGF CTCF ZNF792 WRNIP1 RAD21 ZNF791 SCRT2 ZNF169 ZNF547 SMC3 SMG9 PLAUR KCNN4 ZNF45 ZNF224 ZNF180 ZNF234 ZNF155 IRGC ZNF284
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PLAUR on UCSC Golden Path with GeneCards custom track

Promoters for PLAUR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000347094 1147 2801 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 ZNF416 ZNF143 FOS

Genomic Location for PLAUR Gene

Chromosome:
19
Start:
43,646,095 bp from pter
End:
43,670,547 bp from pter
Size:
24,453 bases
Orientation:
Minus strand

Genomic View for PLAUR Gene

Genes around PLAUR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAUR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAUR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAUR Gene

Proteins for PLAUR Gene

  • Protein details for PLAUR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03405-UPAR_HUMAN
    Recommended name:
    Urokinase plasminogen activator surface receptor
    Protein Accession:
    Q03405
    Secondary Accessions:
    • A8K409
    • Q12876
    • Q15845
    • Q16887
    • Q6IB52
    • Q9BWT0
    • Q9NYC8
    • Q9UD69
    • Q9UEA6
    • Q9UM92
    • Q9UMV0

    Protein attributes for PLAUR Gene

    Size:
    335 amino acids
    Molecular mass:
    36978 Da
    Quaternary structure:
    • Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with SORL1. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane.

    Three dimensional structures from OCA and Proteopedia for PLAUR Gene

    Alternative splice isoforms for PLAUR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLAUR Gene

Post-translational modifications for PLAUR Gene

  • Glycosylation at Asn 74, Asn 184, Asn 194, Asn 222, and Asn 255
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLAUR (uPAR)

No data available for DME Specific Peptides for PLAUR Gene

Domains & Families for PLAUR Gene

Gene Families for PLAUR Gene

Graphical View of Domain Structure for InterPro Entry

Q03405

UniProtKB/Swiss-Prot:

UPAR_HUMAN :
  • Contains 3 UPAR/Ly6 domains.
Domain:
  • Contains 3 UPAR/Ly6 domains.
genes like me logo Genes that share domains with PLAUR: view

Function for PLAUR Gene

Molecular function for PLAUR Gene

GENATLAS Biochemistry:
plasminogen activator urokinase receptor,significantly diminished in diffuse type gastric carcinoma
UniProtKB/Swiss-Prot Function:
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Gene Ontology (GO) - Molecular Function for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity NAS 1689240
GO:0005102 receptor binding IPI 12665524
GO:0005515 protein binding IPI 11290596
GO:0019899 enzyme binding IPI 14688365
GO:0019904 protein domain specific binding IPI 12665524
genes like me logo Genes that share ontologies with PLAUR: view
genes like me logo Genes that share phenotypes with PLAUR: view

Animal Models for PLAUR Gene

MGI Knock Outs for PLAUR:

Animal Model Products

miRNA for PLAUR Gene

miRTarBase miRNAs that target PLAUR

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAUR Gene

Localization for PLAUR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAUR Gene

Cell membrane. Cell projection, invadopodium membrane. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269 PubMed:12376466}.
Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLAUR Gene COMPARTMENTS Subcellular localization image for PLAUR gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 4
cytoskeleton 2
cytosol 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with PLAUR: view

Pathways & Interactions for PLAUR Gene

genes like me logo Genes that share pathways with PLAUR: view

SIGNOR curated interactions for PLAUR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLAUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 22984561
GO:0006928 movement of cell or subcellular component NAS 1689240
GO:0006935 chemotaxis TAS 10749881
GO:0007165 signal transduction TAS 10749881
GO:0007596 blood coagulation NAS 8392005
genes like me logo Genes that share ontologies with PLAUR: view

Drugs & Compounds for PLAUR Gene

(58) Drugs for PLAUR Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urokinase Approved, Investigational, Withdrawn Pharma activator, Target 0
Alteplase Approved Pharma Target 0
Anistreplase Approved Pharma Target 0
Reteplase Approved Pharma Target 6
Tenecteplase Approved Pharma Target 40

(51) Additional Compounds for PLAUR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLAUR: view

Transcripts for PLAUR Gene

Unigene Clusters for PLAUR Gene

Plasminogen activator, urokinase receptor:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAUR Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - -
SP7: - -
SP8: - - -
SP9: - - - - -
SP10:
SP11:

Relevant External Links for PLAUR Gene

GeneLoc Exon Structure for
PLAUR
ECgene alternative splicing isoforms for
PLAUR

Expression for PLAUR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLAUR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAUR Gene

This gene is overexpressed in Whole Blood (x22.6).

Protein differential expression in normal tissues from HIPED for PLAUR Gene

This gene is overexpressed in Cervix (35.7), Peripheral blood mononuclear cells (11.5), and Breast (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLAUR Gene



NURSA nuclear receptor signaling pathways regulating expression of PLAUR Gene:

PLAUR

SOURCE GeneReport for Unigene cluster for PLAUR Gene:

Hs.466871

mRNA Expression by UniProt/SwissProt for PLAUR Gene:

Q03405-UPAR_HUMAN
Tissue specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
genes like me logo Genes that share expression patterns with PLAUR: view

Primer Products

No data available for Protein tissue co-expression partners for PLAUR Gene

Orthologs for PLAUR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAUR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLAUR 34 35
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia PLAUR 34 35
  • 80.67 (n)
cow
(Bos Taurus)
Mammalia PLAUR 34 35
  • 75.73 (n)
rat
(Rattus norvegicus)
Mammalia Plaur 34
  • 70.97 (n)
mouse
(Mus musculus)
Mammalia Plaur 34 16 35
  • 69.78 (n)
oppossum
(Monodelphis domestica)
Mammalia PLAUR 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLAUR 35
  • 31 (a)
OneToOne
Species where no ortholog for PLAUR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLAUR Gene

ENSEMBL:
Gene Tree for PLAUR (if available)
TreeFam:
Gene Tree for PLAUR (if available)

Paralogs for PLAUR Gene

No data available for Paralogs for PLAUR Gene

Variants for PLAUR Gene

Sequence variations from dbSNP and Humsavar for PLAUR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10408734 -- 43,649,817(+) ctttc(A/G)ggaga intron-variant
rs10415717 -- 43,672,181(+) cagga(A/C)gcaaa upstream-variant-2KB
rs10524578 -- 43,660,184(+) TTTTG(-/TTTTG/TTTTGTTTTG)AGACA intron-variant
rs111247667 -- 43,665,268(+) GGTTG(A/G)GCTGG intron-variant
rs111294086 -- 43,663,384(+) CAGGG(C/T)ACAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLAUR Gene

Variant ID Type Subtype PubMed ID
esv2445332 CNV insertion 19546169
esv3893220 CNV gain 25118596
nsv833839 CNV loss 17160897

Variation tolerance for PLAUR Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.73; 86.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLAUR Gene

Human Gene Mutation Database (HGMD)
PLAUR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAUR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAUR Gene

Disorders for PLAUR Gene

MalaCards: The human disease database

(18) MalaCards diseases for PLAUR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ureter cancer
  • malignant tumour of ureter
perforated corneal ulcer
paroxysmal nocturnal hemoglobinuria
  • marchiafava-micheli disease
lipodermatosclerosis
  • acute lipodermatosclerosis
lymph node cancer
  • lymph node neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search PLAUR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLAUR

Genetic Association Database (GAD)
PLAUR
Human Genome Epidemiology (HuGE) Navigator
PLAUR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLAUR
genes like me logo Genes that share disorders with PLAUR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAUR Gene

Publications for PLAUR Gene

  1. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline. (PMID: 19443020) Barton S.J. … Sayers I. (J. Allergy Clin. Immunol. 2009) 3 22 46 64
  2. PLAUR polymorphisms and lung function in UK smokers. (PMID: 19878584) Stewart C.E. … Sayers I. (BMC Med. Genet. 2009) 3 22 46 64
  3. Cell-surface acceleration of urokinase-catalyzed receptor cleavage. (PMID: 9030717) Hoeyer-Hansen G. … Danoe K. (Eur. J. Biochem. 1997) 3 4 22 64
  4. The structure of the urokinase-type plasminogen activator receptor gene. (PMID: 8049431) Casey J.R. … Rosse W.F. (Blood 1994) 3 4 22 64
  5. Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid- anchored membrane proteins. (PMID: 8394346) Ploug M. … Danoe K. (J. Biol. Chem. 1993) 3 4 22 64

Products for PLAUR Gene

Sources for PLAUR Gene

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