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PLAU Gene

protein-coding   GIFtS: 74
GCID: GC10P075668

Plasminogen Activator, Urokinase

  See PLAU-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Plasminogen Activator, Urokinase1 2     UPA2
U-Plasminogen Activator2 3     Plasminogen Activator, Urinary2
EC 3.4.21.733 8     u-PA2
BDPLT52 5     Urokinase-Type Plasminogen Activator2
QPD2 5     uPA3
URK2 5     EC 3.4.218
ATF2     

External Ids:    HGNC: 90521   Entrez Gene: 53282   Ensembl: ENSG000001228617   OMIM: 1918405   UniProtKB: P007493   

Export aliases for PLAU gene to outside databases

Previous GC identifers: GC10P074625 GC10P074774 GC10P075561 GC10P075015 GC10P075340 GC10P069666


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLAU Gene:
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell
migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's
disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by
specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to
form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the
catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular
weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into
a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the
uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Feb 2009)

GeneCards Summary for PLAU Gene:
PLAU (plasminogen activator, urokinase) is a protein-coding gene. Diseases associated with PLAU include quebec platelet disorder, and alzheimer disease type 2. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is LPA.

UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
Function: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin

Gene Wiki entry for PLAU Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLAU gene promoter:
         AML1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PLAU

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLAU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q24

PLAU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLAU gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P075668:  view genomic region     (about GC identifiers)

Start:
75,668,935 bp from pter      End:
75,677,259 bp from pter
Size:
8,325 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UROK_HUMAN, P00749 (See protein sequence)
Recommended Name: Urokinase-type plasminogen activator precursor  
Size: 431 amino acids; 48507 Da
Subunit: Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass
form contains a long chain A which is cleaved to yield a short chain A. Forms heterodimer with SERPINA5. Binds
LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR
Selected PDB 3D structures from and Proteopedia for PLAU (see all 93):
1C5W (3D)        1C5X (3D)        1C5Y (3D)        1C5Z (3D)        1EJN (3D)        1F5K (3D)    
Secondary accessions: B4DPZ2 Q15844 Q16618 Q53XS3 Q5SWW9 Q969W6
Alternative splicing: 2 isoforms:  P00749-1   P00749-2   

Explore the universe of human proteins at neXtProt for PLAU: NX_P00749

Explore proteomics data for PLAU at MOPED

Post-translational modifications: 

  • Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding1
  • Glycosylation2 at Thr38, Ser158, Asn322
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PLAU (P00749) (see all 17)
     CNCPKKF  NYCRNPD  CEITGFG  LGLGKHN 


    See PLAU Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138503.1  NP_002649.1  

    ENSEMBL proteins: 
     ENSP00000474318   ENSP00000361850   ENSP00000361848   ENSP00000388474  
    Reactome Protein details: P00749

    PLAU Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PLAU Protein
    R&D Systems Recombinant & Natural Proteins for PLAU (u-Plasminogen Activator/Urokinase)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PLAU
    OriGene Protein Over-expression Lysate for PLAU
    OriGene MassSpec for PLAU
    OriGene Custom Protein Services for PLAU
    GenScript Custom Purified and Recombinant Proteins Services for PLAU
    Novus Biologicals PLAU Proteins
    Novus Biologicals PLAU Lysate
    Sino Biological Recombinant Protein for PLAU
    Sino Biological Cell Lysate for PLAU
    ProSpec Recombinant Protein for PLAU
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PLAU 

    PLAU Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PLAU
    R&D Systems Antibodies for PLAU (u-Plasminogen Activator/Urokinase)
    OriGene Antibodies for PLAU
    OriGene Custom Antibody Services for PLAU
    Novus Biologicals PLAU Antibodies
    Abcam antibodies for PLAU
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PLAU
    LSBio Antibodies in human, mouse, rat for PLAU

    PLAU Assay Products:

    EMD Millipore Kits and Assays for the Analysis of PLAU
    OriGene Custom Assay Services for PLAU
    R&D Systems ELISAs for PLAU (u-Plasminogen Activator/Urokinase)         (see all)
    GenScript Custom Assay Services for PLAU
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PLAU 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR001314 Peptidase_S1A
     IPR000742 EG-like_dom
     IPR018056 Kringle_CS
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry P00749

    ProtoNet protein and cluster: P00749

    4 Blocks protein domains:
    IPB000001 Kringle
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PLAU           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UROK_HUMAN, P00749
    Function: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin
    Catalytic activity: Specific cleavage of Arg- -Val bond in plasminogen to form plasmin
    Enzyme regulation: Inhibited by SERPINA5

         Genatlas biochemistry entry for PLAU:
    plasminogen activator,urokinase serine protease,involved in plasminogen activation to plasmin

         Enzyme Numbers (IUBMB): EC 3.4.21.731 2 EC 3.4.212

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity TAS--
    GO:0005515protein binding IPI10340997
         
    Find genes that share ontologies with PLAU           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PLAU:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased cell death HMECs cel 

         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for Plau) (see all 20):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with PLAU           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Plautm1Mlg for PLAU

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLAU
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLAU

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLAU
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLAU

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for PLAU (see all 381):
    A4GALT,  AATK,  ACRBP,  ACY3,  ADAM17,  ADAT3,  ADRB1,  ALOX15,  ALPPL2,  AMACR

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLAU:
    hsa-mir-192-5p (MIRT026220), hsa-mir-23b-3p (MIRT004291), hsa-mir-193b-3p (MIRT004413), hsa-mir-215-5p (MIRT024290)

    Block miRNA regulation of human, mouse, rat PLAU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLAU (see all 20):
    hsa-miR-3130-5p hsa-miR-582-3p hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-181c hsa-miR-548s hsa-miR-23a hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLAU 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLAU
    Predesigned siRNA for gene silencing in human, mouse, rat PLAU

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLAU

    Clone
    Products:
         
    OriGene clones in human, mouse for PLAU (see all 12)
    OriGene ORF clones in mouse, rat for PLAU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLAU (NM_002658)
    Sino Biological Human cDNA Clone for PLAU
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLAU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAU
    Addgene plasmids for PLAU 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLAU
    Browse ESI BIO Cell Lines and PureStem Progenitors for PLAU 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAU

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10851 VA6-13082) for PLAU 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UROK_HUMAN, P00749: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytoskeleton2
    cytosol2
    nucleus2
    lysosome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA18835034
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA18835034

    Find genes that share ontologies with PLAU           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLAU About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    2Formation of Fibrin Clot (Clotting Cascade)
    Blood Coagulation Signaling Pathways0.51
    Blood Clotting Cascade0.42
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Apoptotic Pathways in Synovial Fibroblasts
    Glioma Invasiveness0.64
    5Integrin Pathway
    UPA-UPAR Pathway0.56


    Find genes that share SuperPaths with PLAU           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PLAU
        Blood Coagulation Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLAU
        Glioma Invasiveness
    UPA-UPAR Pathway

    5 GeneGo (Thomson Reuters) Pathways for PLAU
        Development VEGF signaling via VEGFR2 - generic cascades
    Cell adhesion PLAU signaling
    Development HGF signaling pathway
    Cell adhesion ECM remodeling
    Cell adhesion Plasmin signaling

    Selected BioSystems Pathways for PLAU (see all 14)
        Osteopontin Signaling
    Senescence and Autophagy
    Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    Blood Clotting Cascade


    1 Reactome Pathway for PLAU
        Dissolution of Fibrin Clot


    5 Kegg Pathways  (Kegg details for PLAU):
        NF-kappa B signaling pathway
    Complement and coagulation cascades
    Transcriptional misregulation in cancer
    Proteoglycans in cancer
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLAU (see all 12): 
              Fibrosis in human mouse rat
              NFKB Signaling Targets in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Wound Healing in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLAU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLAU (P007492, 3 ENSP000003618504) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINE1P051212, 3, ENSP000002230954MINT-8309294 I2D: score=3 STRING: ENSP00000223095
    PLATP007503, ENSP000002208094I2D: score=3 STRING: ENSP00000220809
    CTSBP078583, ENSP000003420704I2D: score=2 STRING: ENSP00000342070
    LRP2P981643, ENSP000002638164I2D: score=2 STRING: ENSP00000263816
    SERPINA5P051543, ENSP000003332034I2D: score=2 STRING: ENSP00000333203
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006508proteolysis TAS6589620
    GO:0006935chemotaxis TAS10749881
    GO:0007165signal transduction TAS10749881
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with PLAU           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PLAU
      Browse compounds at ApexBio 

    Compounds for PLAU available from Tocris Bioscience    About this table
    CompoundAction CAS #
    4-Chlorophenylguanidine hydrochlorideUrokinase inhibitor[14279-91-5]
    BC 11 hydrobromideSelective urokinase (uPA) inhibitor[443776-49-6]

    UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
    Pharmaceutical: Available under the name Abbokinase (Abbott). Used in Pulmonary Embolism (PE) to initiate
    fibrinolysis. Clinically used for therapy of thrombolytic disorders

    Selected DrugBank Compounds for PLAU (see all 33)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AmilorideAmilorida [INN-Spanish] (see all 6)2016-88-8targetinhibitor12183060 12897821 11752352 11544332 15866288 11562773
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--12707394 12579271 12745435 12556741 12824001
    6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine-- --target--17139284 17016423 10592235
    6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine-- --target--17139284 17016423 10592235
    6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine-- --target--17139284 17016423 10592235
    6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine-- --target--17139284 17016423 10592235
    6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine-- --target--17139284 17016423 10592235
    7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide-- --target--17139284 17016423 10592235
    8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide-- --target--17139284 17016423 10592235
    N-(1-Adamantyl)-N'-(4-Guanidinobenzyl)Urea-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for PLAU gene (see all 148)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 81.1 88 16547501 (3), 7559792 (3), 10066093 (2), 16430655 (2) (see all 51)
    serine 79.5 428 1377417 (3), 10805774 (2), 12790317 (2), 11689072 (2) (see all 99)
    aprotinin 69.8 42 7513093 (2), 8857924 (2), 9117184 (1), 10064009 (1) (see all 26)
    epsilon aminocaproic acid 69.4 11 2141608 (1), 7962113 (1), 8869642 (1), 10942782 (1) (see all 9)
    p-amino benzamidine 65.3 23 7759160 (3), 9872599 (2), 9455804 (2), 9436195 (1) (see all 10)
    ecotin 64.7 19 7744876 (5), 9642077 (5), 9642073 (2)
    4-iodobenzo[b]thiophene-2-carboxamidine 64 3 9270032 (1), 10779411 (1)
    fp59 64 3 17041100 (2), 16432166 (1)
    vegf 60.4 256 17704550 (10), 16810742 (6), 12708473 (5), 9738585 (4) (see all 99)
    fibrinogen 56.3 81 15333041 (5), 9714995 (3), 8922882 (3), 8457476 (2) (see all 41)



    Find genes that share compounds with PLAU           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLAU gene (2 alternative transcripts): 
    NM_001145031.1  NM_002658.3  

    Unigene Cluster for PLAU:

    Plasminogen activator, urokinase
    Hs.77274  [show with all ESTs]
    Unigene Representative Sequence: NM_001145031
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481390 ENST00000496926 ENST00000494287 ENST00000372764(uc001jwc.3)
    ENST00000372762(uc009xrq.1) ENST00000446342(uc010qkw.2 uc001jwa.3 uc010qkx.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PLAU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLAU (see all 20):
    hsa-miR-3130-5p hsa-miR-582-3p hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-181c hsa-miR-548s hsa-miR-23a hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLAU 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PLAU
    Predesigned siRNA for gene silencing in human, mouse, rat PLAU
    Clone
    Products:
         
    OriGene clones in human, mouse for PLAU (see all 12)
    OriGene ORF clones in mouse, rat for PLAU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLAU (NM_002658)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLAU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAU
    Addgene plasmids for PLAU 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PLAU
    OriGene qSTAR qPCR primer pairs in human, mouse for PLAU
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLAU
      QuantiTect SYBR Green Assays in human, mouse, rat PLAU
      QuantiFast Probe-based Assays in human, mouse, rat PLAU
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10851 VA6-13082) for PLAU 

    Additional mRNA sequence: 

    AB208961.1 AK297940.1 AK298560.1 AK312960.1 AY029537.1 AY820134.1 BC013575.2 BT007391.1 
    D00244.1 D11143.1 K03226.1 M15476.1 X02760.1 Z36790.1 

    10 DOTS entries:

    DT.446645  DT.95220031  DT.100824489  DT.91692725  DT.102824123  DT.100029663  DT.100824490  DT.102824122 
    DT.95205614  DT.97818673 

    Selected AceView cDNA sequences (see all 352):

    AI304724 BM830616 T19420 AA158743 BM993289 T19421 AI273199 AW238819 
    BQ001018 D11143 BQ020813 BX279775 BP351551 BM764130 CK725200 BM853271 
    BQ691736 CD366261 BQ005957 CA447739 BG741013 CF132071 BM848159 BF515581 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PLAU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGTGACC
    PLAU Expression
    About this image


    PLAU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Heart (Cardiovascular System)
             Epicardial Progenitors Cells Epicardium
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Hypoblast (Extraembryonic Tissues)
             Extraembryonic Endoderm Cells Extraembryonic Endoderm
     
     Kidney (Urinary System)
             Metanephros
     
     Yolk Sac (Extraembryonic Tissues)
             Extraembryonic Endoderm Cells Extraembryonic Endoderm
    PLAU Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLAU Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77274

    UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
    Tissue specificity: Expressed in the prostate gland and prostate cancers

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLAU (see all 12): 
              Fibrosis in human mouse rat
              NFKB Signaling Targets in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Wound Healing in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for PLAU
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    QuantiFast Probe-based Assays in human, mouse, rat PLAU
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for PLAU gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plau1 , 5 plasminogen activator, urokinase1, 5 77.75(n)1
    71.22(a)1
      14 (11.53 cM)5
    187921  NM_008873.31  NP_032899.11 
     208366625 
    chicken
    (Gallus gallus)
    Aves PLAU1 plasminogen activator, urokinase 56.8(n)
    50.13(a)
      396424  NM_205443.2  NP_990774.2 
    lizard
    (Anolis carolinensis)
    Reptilia PLAU6
    plasminogen activator, urokinase
    44(a)
    1 ↔ 1
    GL343196.1(1862161-1883022)
    zebrafish
    (Danio rerio)
    Actinopterygii plaua1 plasminogen activator, urokinase a 51.2(n)
    43.98(a)
      100008445  NM_001172401.1  NP_001165872.1 


    ENSEMBL Gene Tree for PLAU (if available)
    TreeFam Gene Tree for PLAU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLAU gene
    LPA2  HABP22  MST12  F122  PLG2  PLAT2  HGF2  HGFAC2  
    Selected SIMAP similar genes for PLAU using alignment to 5 protein entries:     UROK_HUMAN (see all proteins) (see all similar genes):
    ATF    TMPRSS11D    DKFZp586F0824    GZMK    DKFZp686I03148    CTRB1
    CTRB2    F12    CTRL    PROC1    TMPRSS13    PRSS45
    TMPRSS5    PROC    KLK8    KLK13    CELA3A    GZMM

    Find genes that share paralogs with PLAU           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLAU (see all 251)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22275641,2,,4
    C,F,Hother176046118(+) AAAGCC/TGCTTG 4 P L mis134Minor allele frequency- T:0.18NS MN EA NA WA CSA EU 9988
    rs1403134091,2
    --69663797(+) CGGAAG/TGGGAG 2 -- us2k10--------
    rs1127848851,2
    C--75672377(+) TCAAGT/-GTGAG 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs615675511,2
    C--75672607(+) AAAAAA/-TAAAA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1903149991,2
    --76041883(+) GGGAGA/GAAGGG 2 -- us2k10--------
    rs1818410881,2
    --76041895(+) GTCACG/TCTTCA 2 -- us2k10--------
    rs1850401371,2
    --76041896(+) TCACGC/TTTCAT 2 -- us2k10--------
    rs1147818781,2
    F--76041997(+) CATGAG/AAGCTG 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1882421881,2
    --76042027(+) CATGAC/TGGTCC 2 -- us2k10--------
    rs24594491,2
    C,F,A,H--76042030(+) GACGGC/TCCCTG 2 -- us2k123Minor allele frequency- T:0.32NS EA NA WA CSA 2340

    HapMap Linkage Disequilibrium report for PLAU (75668935 - 75677259 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLAU:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv46n21CNV Loss19592680
    nsv521018CNV Gain19592680
    nsv825468CNV Gain20364138

    Human Gene Mutation Database (HGMD): PLAU
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing PLAU:
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing PLAU
    DNA2.0 Custom Variant and Variant Library Synthesis for PLAU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 191840   
    OMIM disorders: 104300  601709  
    UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
  • Quebec platelet disorder (QPD) [MIM:601709]: An autosomal dominant bleeding disorder due to a
    gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they
    show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased
    PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of
    alpha-granule proteins. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 13 diseases for PLAU:    
    About MalaCards
    quebec platelet disorder    alzheimer disease type 2    angiostrongyliasis    eosinophilic meningitis
    paranasal sinus disease    conjunctivochalasis    dermatitis herpetiformis    pancreatic cancer
    alzheimer's disease    meningioma    ovarian cancer    prostate cancer
    breast cancer

    8 diseases from the University of Copenhagen DISEASES database for PLAU:
    Breast cancer     Carcinoma     Prostate cancer     Ovarian cancer
    Colorectal cancer     Vascular disease     Lung cancer     Malignant glioma

    Find genes that share disorders with PLAU           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PLAU gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 80.7 884 15150277 (5), 7866567 (5), 17264329 (4), 11410166 (4) (see all 99)
    quebec platelet disorder 80.3 13 19029443 (2), 12888877 (1), 18600101 (1), 15026313 (1) (see all 6)
    tumors 74.7 1838 11820719 (7), 10091785 (6), 14581368 (6), 10218628 (6) (see all 99)
    cancer 69.2 820 17923479 (7), 9815571 (5), 12168869 (5), 10091785 (5) (see all 99)
    breast cancer 68.9 747 17222367 (10), 15131040 (9), 11489825 (8), 17704550 (8) (see all 99)
    ovarian cancer 58.6 145 11410515 (4), 15653692 (3), 9194591 (3), 17611702 (3) (see all 66)
    fibrosarcoma 56.1 36 1901800 (2), 9164658 (2), 15033370 (2), 1652590 (1) (see all 21)
    prostate cancer 55.1 246 10221568 (7), 16127174 (5), 18439850 (5), 17571974 (4) (see all 83)
    cancer invasiveness 52.6 3 11079728 (1), 8162583 (1)
    breast carcinoma 52.4 73 15274061 (3), 8687092 (3), 9635840 (3), 11021826 (2) (see all 37)

    Genetic Association Database (GAD): PLAU
    Human Genome Epidemiology (HuGE) Navigator: PLAU (57 documents)

    Export disorders for PLAU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLAU gene, integrated from 10 sources (see all 2313):
    (articles sorted by number of sources associating them with PLAU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene. (PubMed id 20007542)1, 2, 4 Paterson A.D.... Hayward C.P. (Blood 2010)
    2. Molecular cloning of cDNA coding for human preprourokinase. (PubMed id 2415429)1, 2, 3 Nagai M.... Suyama T. (Gene 1985)
    3. Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis. (PubMed id 17877801)1, 4, 9 Jessen K.M....Benfield T. (BMC Infect. Dis. 2007)
    4. Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. (PubMed id 15988036)1, 2, 9 Ustach C.V. and Kim H.-R.C. (Mol. Cell. Biol. 2005)
    5. Antigen levels of the urokinase-type plasminogen activator and its gene polymorphisms in colorectal cancer. (PubMed id 12430175)1, 4, 9 PrzybyA8owska K....BA8asiak J. (Cancer Lett. 2002)
    6. Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility. (PubMed id 10340997)1, 2, 9 He S.... Liu Y.X. (Mol. Hum. Reprod. 1999)
    7. Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer. (PubMed id 9194591)1, 2, 9 Turkmen B.... Magdolen V. (Electrophoresis 1997)
    8. A C/T polymorphism in the urokinase-type plasminogen activator gene in colorectal cancer. (PubMed id 11876553)1, 4, 9 Przybylowska K....Pander B. (amp 2001)
    9. Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis. (PubMed id 17649957)1, 4, 9 Chang L.C....Wu H.P. (amp 2006)
    10. A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease. (PubMed id 16825285)1, 4, 9 Riemenschneider M....Kurz A. (Hum. Mol. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5328 HGNC: 9052 AceView: PLAU Ensembl:ENSG00000122861 euGenes: HUgn5328
    ECgene: PLAU Kegg: 5328 H-InvDB: PLAU

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLAU Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLAU Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Urokinase
    SeattleSNPshttp://pga.gs.washington.edu/data/plau/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLAU gene:
    Search GeneIP for patents involving PLAU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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