Aliases for PLAU Gene
External Ids for PLAU Gene
Previous GeneCards Identifiers for PLAU Gene
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
GeneCards Summary for PLAU Gene
PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases associated with PLAU include quebec platelet disorder and alzheimer disease. Among its related pathways are Proteoglycans in cancer and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PLAT.
UniProtKB/Swiss-Prot for PLAU Gene
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin