V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

PLAU Gene

protein-coding GIFtS: 69

GC10P075340

plasminogen activator, urokinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ATF ^²
EC 3.4.21.73 ^³
OTTHUMP00000019849 ^²
UPA ^¹, ²
URK ^¹, ², ⁵
u-PA ^²
uPA ^³

Descriptions
U-plasminogen activator ^², ³
plasminogen activator, urinary ^²
plasminogen activator, urokinase ^²
urokinase-type plasminogen activator ^²

External Ids
HGNC: 9052¹
Entrez Gene: 5328²
UniProtKB: P00749³
Ensembl: ENSG00000122861⁷

Search outside databases for aliases for PLAU gene

Previous GC identifers: GC10P074625 GC10P074774 GC10P075561 GC10P075015

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PLAU:

This gene encodes a serine protease involved in degradation of the extracellular matrix and

possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be

associated with late-onset Alzheimer's disease and also with decreased affinity for

fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val

bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain

derivative in which a single disulfide bond connects the amino-terminal A-chain to the

catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA

(high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight

uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is

proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript

variants encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: UROK_HUMAN, P00749

Function: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin

Gene Wiki entry for PLAU

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PLAU gene

Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q22.2 HGNC cytogenetic band: 10q24

PLAU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P075340: (about GC identifiers)

Start:	75,340,896 bp from pter
End:	75,347,261 bp from pter
Size:	6,366 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: UROK_HUMAN, P00749 (See protein sequence)

Recommended Name: Urokinase-type plasminogen activator precursor

Size: 431 amino acids; 48525 Da

Subunit: Found in high and low molecular mass forms. Each consists of two chains, A and B. The high

molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds

LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with

PLAUR

Subcellular location: Secreted

PDB structures from and Proteopedia :

1C5W (3D)

1C5X (3D)

1C5Y (3D)

1C5Z (3D)

1EJN (3D)

1F5K (3D)

1F5L (3D)

1F92 (3D)

1FV9 (3D)

1GI7 (3D)

1GI8 (3D)

1GI9 (3D)

1GJ7 (3D)

1GJ8 (3D)

1GJ9 (3D)

1GJA (3D)

1GJB (3D)

1GJC (3D)

1GJD (3D)

1KDU (3D)

1LMW (3D)

1O3P (3D)

1O5A (3D)

1O5B (3D)

1O5C (3D)

1OWD (3D)

1OWE (3D)

1OWH (3D)

1OWI (3D)

1OWJ (3D)

1OWK (3D)

1SC8 (3D)

1SQA (3D)

1SQO (3D)

1SQT (3D)

1U6Q (3D)

1URK (3D)

1VJ9 (3D)

1VJA (3D)

1W0Z (3D)

1W10 (3D)

1W11 (3D)

1W12 (3D)

1W13 (3D)

1W14 (3D)

2FD6 (3D)

2I9A (3D)

2I9B (3D)

2NWN (3D)

2O8T (3D)

2O8U (3D)

2O8W (3D)

2VIN (3D)

2VIO (3D)

2VIP (3D)

2VIQ (3D)

2VIV (3D)

2VIW (3D)

2VNT (3D)

3BT1 (3D)

3BT2 (3D)

Secondary accessions: Q15844 Q16618 Q969W6

Post-translational modifications:

Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with

receptor binding¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001138503.1 NP_002649.1

ENSEMBL proteins:

ENSP00000361850 ENSP00000361847 ENSP00000361848

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant PLAU Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for PLAU (uPA)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Urokinase)
	Human Recombinant Proteins from Abnova (PLAU)

OriGene Purified Recombinant Human Protein: PLAU

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	EXP	2544876

About this table

Antibodies for PLAU:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PLAU
	Sigma-Aldrich Antibodies for PLAU
	R&D Systems Antibodies for PLAU (uPA)
	Antibodies from Abcam (Urokinase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PLAU)
	Novus Biologicals Antibodies for PLAU

Assays for PLAU:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of PLAU
	R&D Systems ELISAs for PLAU (uPA) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P00749

ProtoNet protein and cluster: P00749

4 Blocks protein families:

IPB000001 Kringle

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: UROK_HUMAN, P00749

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 kringle domain

Similarity: Contains 1 peptidase S1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PLAU)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PLAU)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002658

Applied Biosystems Silencer® siRNAs for PLAU

Sigma-Aldrich siRNA and siRNA Panels for PLAU

Sigma-Aldrich shRNA for PLAU

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PLAU
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145031
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145031
untagged cDNA clones in CMV expression vector (see all 2): NM_001145031

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002658

UniProtKB/Swiss-Prot: UROK_HUMAN, P00749

Function: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin

Catalytic activity: Specific cleavage of Arg- -Val bond in plasminogen to form plasmin

Enzyme Number (IUBMB): EC 3.4.21.73

Genatlas biochemistry entry for PLAU:

plasminogen activator,urokinase serine protease,involved in plasminogen activation to plasmin

15/20 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Plau) (see all 20 ):

	cellular	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
lethality-prenatal/perinatal	life span-post-weaning/aging	muscle	nervous system	other

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for PLAU (Your Favorite Gene powered by Ingenuity)

Coagulation System
Oncostatin M Signaling

GeneDecks PLAU for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PLAU

5/134 Interacting proteins for PLAU (ENSP00000361848³) via UniProtKB, MINT, and/or STRING (see all 134 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLAUR	ENSP00000339328³	STRING (score=.999)
SERPINB2	ENSP00000299502³	STRING (score=.999)
SERPINE1	ENSP00000223095³	STRING (score=.999)
FOS	ENSP00000306245³	STRING (score=.996)
VTN	ENSP00000226218³	STRING (score=.995)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	6589620
GO:0006935	chemotaxis	TAS	10749881
GO:0007165	signal transduction	TAS	10749881
GO:0007596	blood coagulation	IEA	--
GO:0042730	fibrinolysis	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for PLAU:

Inhibitor

Compounds for PLAU available from Tocris Bioscience

Compound	Action	CAS number
4-Chlorophenylguanidine hydrochloride	Urokinase inhibitor	[14279-91-5]

About this table

UniProtKB/Swiss-Prot: UROK_HUMAN, P00749

Pharmaceutical: Available under the name Abbokinase (Abbott). Used in Pulmonary Embolism (PE) to

initiates fibrinolysis. Clinically used for therapy of thrombolytic disorders

10/48 Novoseek chemical compound relationships for PLAU gene (see all 48 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	81.31	86	16547501 (3), 7559792 (3), 10066093 (2), 16430655 (2) (see all 49)
p-amino benzamidine	66.31	23	7759160 (3), 9872599 (2), 9455804 (2), 9436195 (1) (see all 10)
4-iodobenzo[b]thiophene-2-carboxamidine	64.49	3	9270032 (1), 10779411 (1)
fp59	64.48	3	17041100 (2), 16432166 (1)
ecotin	63.18	19	7744876 (5), 9642077 (5), 9642073 (2)
fibrinogen	57.24	81	15333041 (5), 9714995 (3), 8922882 (3), 8457476 (2) (see all 41)
microplasmin	51.71	1	17126563 (1)
co 115	50.47	5	7962113 (2), 7657515 (2)
tgf beta1	46.78	43	11505481 (6), 15268802 (4), 9623591 (3), 17187779 (3) (see all 13)
oxamflatin	46.21	7	11004477 (3), 15122596 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PLAU)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PLAU)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002658

Sigma-Aldrich siRNA and siRNA Panels for PLAU

Sigma-Aldrich shRNA for PLAU

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002658

REFSEQ mRNAs for PLAU gene (2 alternative transcripts):

NM_001145031.1 NM_002658.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002658

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145031
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145031
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001145031

Additional cDNA sequence:

AB208961.1 AK297940.1 AK298560.1 AK312960.1 AY029537.1 AY820134.1 BC013575.2 BT007391.1

D00244.1 D11143.1 K03226.1 M15476.1 X02760.1 Z36790.1

10 DOTS entries:

DT.446645 DT.95220031 DT.100824489 DT.91692725 DT.102824123 DT.100029663 DT.100824490 DT.102824122

DT.95205614 DT.97818673

24/352 AceView cDNA sequences (see all 352 ):

BQ691736 CA447739 BQ001018 AU099254 BM830616 AW170309 AI608891 BM993289

BM853271 CD367721 CD366261 CF132071 D11143 CA848267 AW238819 BU073227

BE620141 AA158743 BM764130 AW026240 T19421 BF087520 T19420 AI304724

highest scoring ESTs for PLAU:

AA039591 AA040727 AA100117 AA157530 AA158743 AA161208 AA192627 AA284668 AA284669 AA583615

Unigene Cluster for PLAU:

Plasminogen activator, urokinase

Hs.77274 [show with all ESTs]

Unigene Representative Sequence: NM_001145031

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000372764 ENST00000372761 ENST00000372762

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PLAU expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PLAU

¹ / ² / ³

5 probe-sets matching PLAU gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37310_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X02419	0.20	1.00	0.72	1
205479_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002658	0.60	1.00	0.82	1
211668_s_at²^{, 3}	U133-A	3	1.00	0.94	--	--	K03226	0.80	1.00	0.91	1
205479_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211668_s_at²	U133Plus2	3	1.00	0.94	--	--	--	--	--	--	--

GeneDecks PLAU for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACCTGTGACC

SOURCE GeneReport for Unigene cluster: Hs.77274
Expression variation in blood from EXPOLDB for PLAU
UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
Tissue specificity: Expressed in the prostate gland and prostate cancers

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PLAU gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PLAU¹	--	plasminogen activator, urokinase	84.43(n) 79.34(a)	403426 XM_536394.2 XP_536394.2
cow (Bos taurus)	PLAU¹	--	plasminogen activator, urokinase	82.91(n) 75.41(a)	281408 NM_174147.2 NP_776572.1
rat (Rattus norvegicus)	Plau¹	--	plasminogen activator, urokinase	77.36(n) 71.16(a)	25619 NM_013085.2 NP_037217.2
mouse (Mus musculus)	Plau^{1, 5}	14 (2.50 cM)⁵	plasminogen activator, urokinase^{1, 5}	76.9(n)¹ 69.53(a)¹	18792¹ NM_008873.2¹ NP_032899.1¹ AK054349⁵ BC120709⁵ (see all 9)
chicken (Gallus gallus)	PLAU¹	--	plasminogen activator, urokinase	56.44(n) 50.13(a)	396424 NM_205443.1 NP_990774.1

About this table Species with no ortholog for PLAU

ENSEMBL Gene Tree for PLAU

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PLAU gene

HABP2² F12² PLAT² HGFAC²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/25 NCBI SNPs in PLAU are shown (see all 25 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 45)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4065^1,2	A,C,F,H,O	75346470(+)	`CAGGGC/TGAACG`	1	--	ut3¹ ese³		20		MN EU EA WA NS NA	4314
	rs2227551^1,2	A,C,F,H,O	75339196(+)	`GCATCT/GCTGAC`	1	--	ng5¹ tfbs³		6		NS EU EA WA	512
	rs2459449^1,2	A,C,F,H	75339019(+)	`GACGGC/TCCCTG`	1	--	ng5¹		4		EU EA WA	418
--	rs2227574^1,2	C,F	75347173(+)	`CTCCT-/GTACAC`	1	--	ut3¹		2		NS	94
	rs3805118^1,2	H	75346226(-)	`ATCCAC/AGGCCC`	1	L/R	mis¹ ese³		4		EU EA WA	388
--	rs1050122^1,2	F	75345124(+)	`ATGCTG/ATGTGC`	1	L/L	syn¹ ese³		4		NA EA MN	436
	rs2227571^1,2	A,C,F	75344746(+)	`CCCAGC/TGTGAT`	1	--	int¹		10		NS EA	3182
	rs2227572^1,2	H	75344789(+)	`ACTGAG/AGCGGT`	1	--	int¹		9		NS NA EA EU WA	760
--	rs2227573^1,2	F	75345725(+)	`TGCGTC/GAGGCA`	1	--	int¹		2		NS	94
	rs1804874^1,2	--	75346847(+)	`TATGTG/TTGTGT`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for PLAU (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 191840 disorders: 104300

10/98 Novoseek disease relationships for PLAU gene (see all 98 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	80.53	839	15150277 (5), 7866567 (5), 17264329 (4), 11410166 (4) (see all 99)
quebec platelet disorder	80.34	13	19029443 (2), 12888877 (1), 18600101 (1), 15026313 (1) (see all 6)
tumors	74.57	1764	11820719 (7), 10091785 (6), 14581368 (6), 10218628 (6) (see all 99)
breast cancer	68.87	716	17222367 (10), 15131040 (9), 11489825 (8), 17704550 (8) (see all 99)
cancer	68.80	761	17923479 (7), 9815571 (5), 12168869 (5), 10091785 (5) (see all 99)
ovarian cancer	59.43	142	11410515 (4), 15653692 (3), 9194591 (3), 17611702 (3) (see all 64)
fibrosarcoma	56.22	36	1901800 (2), 9164658 (2), 15033370 (2), 1652590 (1) (see all 21)
cancer invasiveness	54.86	3	11079728 (1), 8162583 (1)
prostate cancer	54.70	233	10221568 (7), 16127174 (5), 18439850 (5), 17571974 (4) (see all 80)
breast carcinoma	52.65	70	15274061 (3), 8687092 (3), 9635840 (3), 11021826 (2) (see all 37)

About this table

Human Gene Mutation Database: PLAU
Genetic Association Database: PLAU
Human Genome Epidemiology Navigator: PLAU (38 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1862 PubMed articles for PLAU gene (see all 1862 ):

Molecular cloning of cDNA coding for human preprourokinase. (PubMed id 2415429)^{2, 3, 4} Nagai M.... Suyama T. (1985)
Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. (PubMed id 15988036)^{1, 3, 4} Ustach C.V. and Kim H.-R.C. (2005)
Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer. (PubMed id 9194591)^{1, 3, 4} Turkmen B.... Magdolen V. (1997)
Antigen levels of the urokinase-type plasminogen activator and its gene polymorphisms in colorectal cancer. (PubMed id 12430175)^{1, 3, 6} Przybyl/owska K....Bl/asiak J. (2002)
A C/T polymorphism in the urokinase-type plasminogen activator gene in colorectal cancer. (PubMed id 11876553)^{1, 3, 6} Przybylowska K....Pander B. (2001)
Structure of human urokinase plasminogen activator in complex with its receptor. (PubMed id 16456079)^{1, 3, 4} Huai Q....Huang M. (2006)
Tumor necrosis factor alpha, CYP 17, urokinase, and interleukin 10 gene polymorphisms in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis. (PubMed id 15927351)^{3, 6} Chen H.Y....Tsai C.H. (2005)
Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. (PubMed id 15615772)^{3, 6} Ertekin-Taner N....Younkin S.G. (2005)
No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits. (PubMed id 15558716)^{3, 6} Papassotiropoulos A....Hock C. (2005)
Distribution of C-->T and T-->C polymorphisms of the urokinase-type plasminogen activator gene in children with type 1 diabetes mellitus and insulin resistance. (PubMed id 15750768)^{3, 6} Majsterek I....Blasiak J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5328	HGNC: 9052	AceView: PLAU	Ensembl:ENSG00000122861	euGenes: HUgn5328
ECgene: PLAU	H-InvDB: PLAU

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PLAU	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Urokinase
SeattleSNPs	http://pga.gs.washington.edu/data/plau/

Licensable Technologies for PLAU
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PLAU:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PLAU-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PLAU		Antibodies for PLAU
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PLAU		Small molecules for PLAU
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PLAU)
	Antibodies (PLAU)
	Chimera RNAi (PLAU)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Urokinase)
	Antibodies (Urokinase)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for PLAU

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PLAU

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PLAU Gene at Home site.
Version 2.41.1
server5.xennexinc.com

PLAU Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for PLAU

Summaries
for PLAU

Genomic Location
for PLAU

Proteins
for PLAU

Protein Domains/
Families
for PLAU

Gene Function
for PLAU

Pathways & Interactions
for PLAU

Drugs & Compounds
for PLAU

Transcripts
for PLAU

Expression
for PLAU

Orthologs
for PLAU

Paralogs
for PLAU

SNPs/Variants
for PLAU

Disorders & Mutations
for PLAU

Medical News
for PLAU

Publications
for PLAU

Search for PLAU

Genome Databases showing PLAU

Other Databases showing PLAU

Specialized Databases showing PLAU

Licensable Technologies
for PLAU

Services
for PLAU

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PLAU Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor PLAU

Summariesfor PLAU

Genomic Locationfor PLAU

Proteinsfor PLAU

Protein Domains/Familiesfor PLAU

Gene Functionfor PLAU

Pathways & Interactionsfor PLAU

Drugs & Compoundsfor PLAU

Transcriptsfor PLAU

Expression for PLAU

Orthologsfor PLAU

Paralogsfor PLAU

SNPs/Variantsfor PLAU

Disorders & Mutationsfor PLAU

Medical Newsfor PLAU

Publicationsfor PLAU

Search for PLAU

Genome Databases showing PLAU

Other Databases showing PLAU

Specialized Databases showing PLAU

Licensable Technologiesfor PLAU

Servicesfor PLAU

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PLAU

Summaries
for PLAU

Genomic Location
for PLAU

Proteins
for PLAU

Protein Domains/
Families
for PLAU

Gene Function
for PLAU

Pathways & Interactions
for PLAU

Drugs & Compounds
for PLAU

Transcripts
for PLAU

Expression
for PLAU

Orthologs
for PLAU

Paralogs
for PLAU

SNPs/Variants
for PLAU

Disorders & Mutations
for PLAU

Medical News
for PLAU

Publications
for PLAU

Licensable Technologies
for PLAU

Services
for PLAU