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Aliases for PLAU Gene

Aliases for PLAU Gene

  • Plasminogen Activator, Urokinase 2 3
  • U-Plasminogen Activator 3 4
  • EC 4 63
  • BDPLT5 3 6
  • UPA 3 4
  • QPD 3 6
  • URK 3 6
  • Urokinase-Type Plasminogen Activator 3
  • Plasminogen Activator, Urinary 3
  • EC 3.4.21 63
  • U-PA 3
  • ATF 3

External Ids for PLAU Gene

Previous GeneCards Identifiers for PLAU Gene

  • GC10P074625
  • GC10P074774
  • GC10P075561
  • GC10P075015
  • GC10P075340
  • GC10P075668
  • GC10P069666

Summaries for PLAU Gene

Entrez Gene Summary for PLAU Gene

  • This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

GeneCards Summary for PLAU Gene

PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases associated with PLAU include quebec platelet disorder and alzheimer disease. Among its related pathways are Proteoglycans in cancer and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PLAT.

UniProtKB/Swiss-Prot for PLAU Gene

  • Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin

Tocris Summary for PLAU Gene

Gene Wiki entry for PLAU Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAU Gene

Genomics for PLAU Gene

Regulatory Elements for PLAU Gene

Transcription factor binding sites by QIAGEN in the PLAU gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLAU Gene

73,909,177 bp from pter
73,917,501 bp from pter
8,325 bases
Plus strand

Genomic View for PLAU Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLAU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAU Gene

Proteins for PLAU Gene

  • Protein details for PLAU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Urokinase-type plasminogen activator
    Protein Accession:
    Secondary Accessions:
    • B4DPZ2
    • Q15844
    • Q16618
    • Q53XS3
    • Q5SWW9
    • Q969W6

    Protein attributes for PLAU Gene

    431 amino acids
    Molecular mass:
    48507 Da
    Quaternary structure:
    • Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Forms heterodimer with SERPINA5. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR.

    Three dimensional structures from OCA and Proteopedia for PLAU Gene

    Alternative splice isoforms for PLAU Gene


neXtProt entry for PLAU Gene

Proteomics data for PLAU Gene at MOPED

Post-translational modifications for PLAU Gene

  • Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
  • Glycosylation at Thr38, Ser158, and Asn322
  • Modification sites at PhosphoSitePlus

Other Protein References for PLAU Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PLAU (u-Plasminogen Activator/Urokinase)

Domains for PLAU Gene

Suggested Antigen Peptide Sequences for PLAU Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EGF-like domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 EGF-like domain.
  • Contains 1 kringle domain.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PLAU: view

No data available for Gene Families for PLAU Gene

Function for PLAU Gene

Molecular function for PLAU Gene

GENATLAS Biochemistry:
plasminogen activator,urokinase serine protease,involved in plasminogen activation to plasmin
UniProtKB/Swiss-Prot CatalyticActivity:
Specific cleavage of Arg- -Val bond in plasminogen to form plasmin
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5.
UniProtKB/Swiss-Prot Function:
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin

Enzyme Numbers (IUBMB) for PLAU Gene

Gene Ontology (GO) - Molecular Function for PLAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 10340997
genes like me logo Genes that share ontologies with PLAU: view
genes like me logo Genes that share phenotypes with PLAU: view

Animal Models for PLAU Gene

MGI Knock Outs for PLAU:

Animal Model Products

miRNA for PLAU Gene

Transcription Factor Targets for PLAU Gene

Selected GeneGlobe predicted Target genes for PLAU

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLAU

In Situ Assay Products

Flow Cytometry Products

No data available for HOMER Transcription for PLAU Gene

Localization for PLAU Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAU Gene


Subcellular locations from

Jensen Localization Image for PLAU Gene COMPARTMENTS Subcellular localization image for PLAU gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
cytosol 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PLAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18835034
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0009986 cell surface IDA 18835034
genes like me logo Genes that share ontologies with PLAU: view

Pathways for PLAU Gene

genes like me logo Genes that share pathways with PLAU: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PLAU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006508 proteolysis TAS 6589620
GO:0006935 chemotaxis TAS 10749881
GO:0007165 signal transduction TAS 10749881
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with PLAU: view

Drugs for PLAU Gene

(34) Drugbank Compounds for PLAU Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • U-plasminogen activator
9039-53-6 Target approved, investigational, withdrawn
  • 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
2016-88-8 16231 Target inhibitor approved
180621 Target experimental
46936909 Target experimental
16758228 Target experimental


Pharmaceutical: Available under the name Abbokinase (Abbott). Used in Pulmonary Embolism (PE) to initiate fibrinolysis. Clinically used for therapy of thrombolytic disorders

(2) Tocris Compounds for PLAU Gene

Compound Action Cas Number
4-Chlorophenylguanidine hydrochloride Urokinase inhibitor [14279-91-5]
BC 11 hydrobromide Selective urokinase (uPA) inhibitor [443776-49-6]

(1) HMDB Compounds for PLAU Gene

Compound Synonyms Cas Number PubMed IDs
  • Amilorida [INN-Spanish]

(148) Novoseek inferred chemical compound relationships for PLAU Gene

Compound -log(P) Hits PubMed IDs
matrigel 81.1 60
serine 79.5 111
aprotinin 69.8 28
epsilon aminocaproic acid 69.4 9
p-amino benzamidine 65.3 14
genes like me logo Genes that share compounds with PLAU: view

Transcripts for PLAU Gene

Unigene Clusters for PLAU Gene

Plasminogen activator, urokinase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLAU

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAU Gene

No ASD Table

Relevant External Links for PLAU Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLAU Gene

mRNA expression in normal human tissues for PLAU Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAU Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.7).

Protein differential expression in normal tissues for PLAU Gene

This gene is overexpressed in Urine (59.7) and Amniocyte (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLAU Gene

SOURCE GeneReport for Unigene cluster for PLAU Gene Hs.77274

mRNA Expression by UniProt/SwissProt for PLAU Gene

Tissue specificity: Expressed in the prostate gland and prostate cancers.
genes like me logo Genes that share expressions with PLAU: view

Expression partners for PLAU Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for PLAU Gene

This gene was present in the common ancestor of animals.

Orthologs for PLAU Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLAU 35
  • 82.93 (n)
  • 75.48 (a)
  • 75 (a)
(Canis familiaris)
Mammalia PLAU 35
  • 84.66 (n)
  • 79.34 (a)
  • 62 (a)
(Mus musculus)
Mammalia Plau 35
  • 77.75 (n)
  • 71.22 (a)
Plau 16
Plau 36
  • 69 (a)
(Pan troglodytes)
Mammalia PLAU 35
  • 99.15 (n)
  • 99.07 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Plau 35
  • 78.26 (n)
  • 72.22 (a)
(Monodelphis domestica)
Mammalia PLAU 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia PLAU 36
  • 52 (a)
(Gallus gallus)
Aves PLAU 35
  • 56.8 (n)
  • 50.13 (a)
  • 43 (a)
(Anolis carolinensis)
Reptilia PLAU 36
  • 44 (a)
(Danio rerio)
Actinopterygii plaua 35
  • 51.2 (n)
  • 43.98 (a)
plaua 36
  • 39 (a)
plaub 36
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11836 37
  • 37 (a)
CG6041 37
  • 37 (a)
Species with no ortholog for PLAU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAU Gene

Gene Tree for PLAU (if available)
Gene Tree for PLAU (if available)

Paralogs for PLAU Gene

Paralogs for PLAU Gene

genes like me logo Genes that share paralogs with PLAU: view

Variants for PLAU Gene

Sequence variations from dbSNP and Humsavar for PLAU Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2227551 -- 73,909,432(+) GCATC(G/T)CTGAC upstream-variant-2KB
rs2459449 -- 73,909,255(+) GACGG(C/T)CCCTG upstream-variant-2KB
rs7894963 -- 73,909,276(+) GATAA(C/T)TAACC upstream-variant-2KB
rs111307659 -- 73,909,255(+) GACGG(-/T)CCCTG upstream-variant-2KB
rs114781878 -- 73,909,222(+) CATGA(A/G)AGCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLAU Gene

Variant ID Type Subtype PubMed ID
nsv825468 CNV Gain 20364138
dgv46n21 CNV Loss 19592680
nsv521018 CNV Gain 19592680

Relevant External Links for PLAU Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

PCR Panel Products

  • Copy Number PCR Panels: for PLAU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAU Gene

Disorders for PLAU Gene

(2) OMIM Diseases for PLAU Gene (191840)


  • Quebec platelet disorder (QPD) [MIM:601709]: An autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. {ECO:0000269 PubMed:20007542}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(98) Novoseek inferred disease relationships for PLAU Gene

Disease -log(P) Hits PubMed IDs
metastasis 80.7 242
quebec platelet disorder 80.3 7
tumors 74.7 362
cancer 69.2 234
breast cancer 68.9 326

Relevant External Links for PLAU

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PLAU: view

No data available for Genatlas for PLAU Gene

Publications for PLAU Gene

  1. Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer. (PMID: 9194591) Turkmen B. … Magdolen V. (Electrophoresis 1997) 3 4 23
  2. (4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase. (PMID: 10805774) Sperl S. … Moroder L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  3. Structure of human urokinase plasminogen activator in complex with its receptor. (PMID: 16456079) Huai Q. … Huang M. (Science 2006) 3 4 23
  4. A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease. (PMID: 16825285) Riemenschneider M. … Kurz A. (Hum. Mol. Genet. 2006) 3 23 48
  5. Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis. (PMID: 17649957) Chang L.C. … Wu H.P. (Arch Environ Occup Health 2006) 3 23 48

Products for PLAU Gene

  • Addgene plasmids for PLAU

Sources for PLAU Gene

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