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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLAU Gene

protein-coding   GIFtS: 74
GCID: GC10P075668

Plasminogen Activator, Urokinase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Plasminogen Activator, Urokinase1 2     UPA2
U-Plasminogen Activator2 3     Plasminogen Activator, Urinary2
EC 3.4.21.733 8     u-PA2
URK2 5     Urokinase-Type Plasminogen Activator2
ATF2     uPA3
BDPLT52     EC 3.4.218
QPD2     

External Ids:    HGNC: 90521   Entrez Gene: 53282   Ensembl: ENSG000001228617   OMIM: 1918405   UniProtKB: P007493   

Export aliases for PLAU gene to outside databases

Previous GC identifers: GC10P074625 GC10P074774 GC10P075561 GC10P075015 GC10P075340 GC10P069666


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLAU Gene:
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell
migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's
disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by
specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to
form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the
catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular
weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into
a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the
uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Feb 2009)

GeneCards Summary for PLAU Gene: 
PLAU (plasminogen activator, urokinase) is a protein-coding gene. Diseases associated with PLAU include quebec platelet disorder, and eosinophilic meningitis, and among its related super-pathways are Complement and Coagulation Cascades and Blood Coagulation Signaling Pathways. GO annotations related to this gene include protein binding and serine-type endopeptidase activity. An important paralog of this gene is LPA.

UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
Function: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin

Gene Wiki entry for PLAU Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLAU gene promoter:
         AML1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PLAU

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLAU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q24

PLAU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLAU gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P075668:  view genomic region     (about GC identifiers)

Start:
75,668,935 bp from pter      End:
75,677,259 bp from pter
Size:
8,325 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UROK_HUMAN, P00749 (See protein sequence)
Recommended Name: Urokinase-type plasminogen activator precursor  
Size: 431 amino acids; 48507 Da
Subunit: Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass
form contains a long chain A which is cleaved to yield a short chain A. Forms heterodimer with SERPINA5. Binds
LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR
Subcellular location: Secreted
6/90 PDB 3D structures from and Proteopedia for PLAU (see all 90):
1C5W (3D)        1C5X (3D)        1C5Y (3D)        1C5Z (3D)        1EJN (3D)        1F5K (3D)    
Secondary accessions: B4DPZ2 Q15844 Q16618 Q53XS3 Q5SWW9 Q969W6
Alternative splicing: 2 isoforms:  P00749-1   P00749-2   

Explore the universe of human proteins at neXtProt for PLAU: NX_P00749

Explore proteomics data for PLAU at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P00749

  • 4/17 DME Specific Peptides for PLAU (P00749) (see all 17)
     CNCPKKF  NYCRNPD  CEITGFG  LGLGKHN 

    PLAU Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLAU Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138503.1  NP_002649.1  

    ENSEMBL proteins: 
     ENSP00000474318   ENSP00000361850   ENSP00000361848   ENSP00000388474  
    Reactome Protein details: P00749
    Human Recombinant Protein Products for PLAU: 
    EMD Millipore Purified and/or Recombinant PLAU Protein
    R&D Systems Recombinant & Natural Proteins for PLAU (u-Plasminogen Activator/Urokinase)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PLAU
    OriGene Protein Over-expression Lysate for PLAU
    OriGene MassSpec for PLAU 
    OriGene Custom Protein Services for PLAU
    GenScript Custom Purified and Recombinant Proteins Services for PLAU
    Novus Biologicals PLAU Proteins
    Novus Biologicals PLAU Lysate
    Sino Biological Recombinant Protein for PLAU
    Sino Biological Cell Lysate for PLAU 
    ProSpec Recombinant Protein for PLAU
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA18835034
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA18835034

    PLAU for ontologies           About GeneDecksing



    PLAU Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PLAU
    R&D Systems Antibodies for PLAU (u-Plasminogen Activator/Urokinase)
    OriGene Antibodies for PLAU
    OriGene Custom Antibody Services for PLAU
    GenScript Custom Superior Antibodies Services for PLAU
    Novus Biologicals PLAU Antibodies
    Abcam antibodies for PLAU
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for PLAU
    LSBio Antibodies in human, mouse, rat for PLAU 

    Assay Products for PLAU: 
    EMD Millipore Kits and Assays for the Analysis of PLAU
    OriGene Custom Assay Services for PLAU
    R&D Systems ELISAs for PLAU (u-Plasminogen Activator/Urokinase)         (see all)
    GenScript Custom Assay Services for PLAU
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR001314 Peptidase_S1A
     IPR000742 EG-like_dom
     IPR018056 Kringle_CS
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry P00749

    ProtoNet protein and cluster: P00749

    4 Blocks protein domains:
    IPB000001 Kringle
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 peptidase S1 domain


    PLAU for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UROK_HUMAN, P00749
    Function: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin
    Catalytic activity: Specific cleavage of Arg- -Val bond in plasminogen to form plasmin
    Enzyme regulation: Inhibited by SERPINA5

         Genatlas biochemistry entry for PLAU:
    plasminogen activator,urokinase serine protease,involved in plasminogen activation to plasmin

         Enzyme Numbers (IUBMB): EC 3.4.21.731 2 EC 3.4.212

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity TAS--
    GO:0005515protein binding IPI10340997
         
    PLAU for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PLAU:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased cell death HMECs cel 

         15/20 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Plau) (see all 20):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  muscle  nervous system 

    PLAU for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Plautm1Mlg for PLAU

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLAU 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLAU

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLAU 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLAU 

    10/386 SABiosciences Target genes for PLAU (see all 386):
    A4GALT AATK ACRBP ACY3 ADAM17 ADAT3 ADRB1 ALOX15 ALPPL2 AMACR

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLAU:
    hsa-mir-23b (MIRT004291), hsa-mir-193b (MIRT004413)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLAU
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate PLAU (see all 20):
    hsa-miR-3130-5p hsa-miR-582-3p hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-181c hsa-miR-548s hsa-miR-23a hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLAU 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLAU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLAU

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLAU
    Sirion Biotech Customized adenovirus for overexpression of PLAU

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PLAU (see all 11)
    OriGene ORF clones in mouse, rat for PLAU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLAU (NM_002658)
    Sino Biological Human cDNA Clone for PLAU
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLAU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAU
    Sirion Biotech Customized lentivirus for stable overexpression of PLAU 
                         Customized lentivirus expression plasmids for stable overexpression of PLAU 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLAU
    Search LifeMap BioReagents cell lines for PLAU
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAU


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLAU About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    2Formation of Fibrin Clot (Clotting Cascade)
    Blood Coagulation Signaling Pathways0.51
    Blood Clotting Cascade0.42
    3Wnt Signaling Pathway
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Development HGF signaling pathway
    Development HGF signaling pathway0.78
    5Apoptotic Pathways in Synovial Fibroblasts
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for PLAU
        Development HGF signaling pathway
    Cell adhesion PLAU signaling
    Cell adhesion ECM remodeling
    Cell adhesion Plasmin signaling

    1 R&D Systems Pathway for PLAU
        Blood Coagulation Signaling Pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLAU
        Glioma Invasiveness
    UPA-UPAR Pathway

    5 GeneGo (Thomson Reuters) Pathways for PLAU
        Development VEGF signaling via VEGFR2 - generic cascades
    Cell adhesion PLAU signaling
    Development HGF signaling pathway
    Cell adhesion ECM remodeling
    Cell adhesion Plasmin signaling

    5/14 BioSystems Pathways for PLAU (see all 14)
        Osteopontin Signaling
    Senescence and Autophagy
    Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Blood Clotting Cascade


    2        Reactome Pathways for PLAU
        Hemostasis
    Dissolution of Fibrin Clot


    5         Kegg Pathways  (Kegg details for PLAU):
        NF-kappa B signaling pathway
    Complement and coagulation cascades
    Transcriptional misregulation in cancer
    Proteoglycans in cancer
    MicroRNAs in cancer


    PLAU for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLAU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for PLAU (P007492, 3 ENSP000003618504) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINE1P051212, 3, ENSP000002230954MINT-8309294 I2D: score=3 STRING: ENSP00000223095
    PLATP007503, ENSP000002208094I2D: score=3 STRING: ENSP00000220809
    CTSBP078583, ENSP000003420704I2D: score=2 STRING: ENSP00000342070
    LRP2P981643, ENSP000002638164I2D: score=2 STRING: ENSP00000263816
    SERPINA5P051543, ENSP000003332034I2D: score=2 STRING: ENSP00000333203
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006508proteolysis IEA--
    GO:0006935chemotaxis TAS10749881
    GO:0007165signal transduction TAS10749881
    GO:0007596blood coagulation TAS--

    PLAU for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLAU for compounds           About GeneDecksing

    EMD Millipore small molecules for PLAU:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PLAU

    Compounds for PLAU available from Tocris Bioscience    About this table
    CompoundAction CAS #
    4-Chlorophenylguanidine hydrochlorideUrokinase inhibitor[14279-91-5]
    BC 11 hydrobromideSelective urokinase (uPA) inhibitor[443776-49-6]

    UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
    Pharmaceutical: Available under the name Abbokinase (Abbott). Used in Pulmonary Embolism (PE) to initiate
    fibrinolysis. Clinically used for therapy of thrombolytic disorders

    10/33 DrugBank Compounds for PLAU (see all 33)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AmilorideAmilorida [INN-Spanish] (see all 6)2016-88-8targetinhibitor12183060 12897821 11752352 11544332 15866288 11562773
    UrokinaseU-plasminogen activator (see all 3)9039-53-6target--12707394 12579271 12745435 12556741 12824001
    6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine-- --target--17139284 17016423 10592235
    6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine-- --target--17139284 17016423 10592235
    6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine-- --target--17139284 17016423 10592235
    6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine-- --target--17139284 17016423 10592235
    6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine-- --target--17139284 17016423 10592235
    7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide-- --target--17139284 17016423 10592235
    8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide-- --target--17139284 17016423 10592235
    N-(1-Adamantyl)-N'-(4-Guanidinobenzyl)Urea-- --target--17139284 17016423 10592235

    10/148 Novoseek inferred chemical compound relationships for PLAU gene (see all 148)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 81.1 88 16547501 (3), 7559792 (3), 10066093 (2), 16430655 (2) (see all 51)
    serine 79.5 428 1377417 (3), 10805774 (2), 12790317 (2), 11689072 (2) (see all 99)
    aprotinin 69.8 42 7513093 (2), 8857924 (2), 9117184 (1), 10064009 (1) (see all 26)
    epsilon aminocaproic acid 69.4 11 2141608 (1), 7962113 (1), 8869642 (1), 10942782 (1) (see all 9)
    p-amino benzamidine 65.3 23 7759160 (3), 9872599 (2), 9455804 (2), 9436195 (1) (see all 10)
    ecotin 64.7 19 7744876 (5), 9642077 (5), 9642073 (2)
    4-iodobenzo[b]thiophene-2-carboxamidine 64 3 9270032 (1), 10779411 (1)
    fp59 64 3 17041100 (2), 16432166 (1)
    vegf 60.4 256 17704550 (10), 16810742 (6), 12708473 (5), 9738585 (4) (see all 99)
    fibrinogen 56.3 81 15333041 (5), 9714995 (3), 8922882 (3), 8457476 (2) (see all 41)

    Search CenterWatch for drugs/clinical trials and news about PLAU / UROK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLAU gene (2 alternative transcripts): 
    NM_001145031.1  NM_002658.3  

    Unigene Cluster for PLAU:

    Plasminogen activator, urokinase
    Hs.77274  [show with all ESTs]
    Unigene Representative Sequence: NM_001145031
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481390 ENST00000496926 ENST00000494287 ENST00000372764(uc001jwc.3)
    ENST00000372762(uc009xrq.1) ENST00000446342(uc010qkw.2 uc001jwa.3 uc010qkx.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLAU
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate PLAU (see all 20):
    hsa-miR-3130-5p hsa-miR-582-3p hsa-miR-3678-3p hsa-miR-193a-3p hsa-miR-181c hsa-miR-548s hsa-miR-23a hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLAU 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PLAU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLAU
    Clone
    Products:
         
    OriGene clones in human, mouse for PLAU (see all 11)
    OriGene ORF clones in mouse, rat for PLAU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PLAU (NM_002658)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLAU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAU
    Sirion Biotech Customized lentivirus for stable overexpression of PLAU 
                         Customized lentivirus expression plasmids for stable overexpression of PLAU 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PLAU
    OriGene qSTAR qPCR primer pairs in human, mouse for PLAU
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLAU
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLAU
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLAU

    Additional mRNA sequence: 

    AB208961.1 AK297940.1 AK298560.1 AK312960.1 AY029537.1 AY820134.1 BC013575.2 BT007391.1 
    D00244.1 D11143.1 K03226.1 M15476.1 X02760.1 Z36790.1 

    10 DOTS entries:

    DT.446645  DT.95220031  DT.100824489  DT.91692725  DT.102824123  DT.100029663  DT.100824490  DT.102824122 
    DT.95205614  DT.97818673 

    24/352 AceView cDNA sequences (see all 352):

    T19421 AI608891 BX279775 AW238819 BE907736 BP351551 BM764130 CF132071 
    AI273199 BQ005957 R10562 AW170309 BQ691736 CD367721 BM830616 CD366261 
    AW770869 CK725200 CA447739 BQ020813 D11143 BG741013 AA158743 BM761640 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLAU expression in normal human tissues (normalized intensities)      PLAU embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGTGACC
    PLAU Expression
    About this image


    PLAU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Epicardial Progenitors Cells Epicardium
             mouse/organ system/cardiovascular system   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Peripheral blood-derived hematopoietic stem cells
             stem cells (umbilical cord cd34+)   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
             Human Renal Mesangial Cells (HRMC)   
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 3 entries
             Villous Cytotrophoblast Cells Chorionic Villus
             Extravillous Cytotrophoblast Layer
     
     Uncategorized (Extraembryonic Tissues)    fully expand to see all 3 entries
             Extra-embryonic endoderm cells

    See PLAU Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLAU

    SOURCE GeneReport for Unigene cluster: Hs.77274

    UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
    Tissue specificity: Expressed in the prostate gland and prostate cancers

        SABiosciences Expression via Pathway-Focused PCR Arrays including PLAU (see all 12): 
              Fibrosis in human mouse rat
              NFKB Signaling Targets in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Wound Healing in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLAU
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PLAU gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plau1 , 5 plasminogen activator, urokinase1, 5 76.9(n)1
    69.53(a)1
      14 (11.53 cM)5
    187921  NM_008873.31  NP_032899.11 
     208366625 
    chicken
    (Gallus gallus)
    Aves PLAU1 plasminogen activator, urokinase 56.27(n)
    50.13(a)
      396424  NM_205443.2  NP_990774.2 
    lizard
    (Anolis carolinensis)
    Reptilia PLAU6
    plasminogen activator, urokinase
    43(a)
    1 ↔ 1
    GL343196.1(1862161-1883022)
    zebrafish
    (Danio rerio)
    Actinopterygii plaua1 plasminogen activator, urokinase a 51.51(n)
    43.98(a)
      100008445  NM_001172401.1  NP_001165872.1 
    worm
    (Caenorhabditis elegans)
    Secernentea svh-16
    Protein SVH-1
    11(a)
    1 → many
    IV(8206614-8213723)


    ENSEMBL Gene Tree for PLAU (if available)
    TreeFam Gene Tree for PLAU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLAU gene
    LPA2  HABP22  MST12  F122  PLG2  PLAT2  HGF2  HGFAC2  
    18/56 SIMAP similar genes for PLAU using alignment to 4 protein entries:     UROK_HUMAN (see all proteins) (see all similar genes):
    ATF    TMPRSS11D    DKFZp586F0824    DKFZp686I03148    GZMK    CTRB1
    CTRB2    F12    CTRL    PROC1    TMPRSS13    PRSS45
    TMPRSS5    PROC    GZMM    KLK8    KLK13    PLAT

    PLAU for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/251 SNPs in PLAU are shown (see all 251)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22275641,2,4
    C,F,Hother176046118(+) AAAGCC/TGCTTG 4 P L mis134Minor allele frequency- T:0.18NS MN EA NA WA CSA EU 9988
    VAR_0131024
    ----see VAR_0131022 I M mis40--------
    rs1403134091,2
    --69663797(+) CGGAAG/TGGGAG 2 -- us2k10--------
    rs1127848851,2
    C--75672377(+) TCAAGT/-GTGAG 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs615675511,2
    C--75672607(+) AAAAAA/-TAAAA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1903149991,2
    --76041883(+) GGGAGA/GAAGGG 2 -- us2k10--------
    rs1818410881,2
    --76041895(+) GTCACG/TCTTCA 2 -- us2k10--------
    rs1850401371,2
    --76041896(+) TCACGC/TTTCAT 2 -- us2k10--------
    rs1147818781,2
    F--76041997(+) CATGAG/AAGCTG 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1882421881,2
    --76042027(+) CATGAC/TGGTCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PLAU (75668935 - 75677259 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLAU:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv46n21CNV Loss19592680
    nsv521018CNV Gain19592680
    nsv825468CNV Gain20364138


    Human Gene Mutation Database (HGMD): PLAU
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing PLAU:
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing PLAU
    DNA2.0 Custom Variant and Variant Library Synthesis for PLAU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191840   
    OMIM disorders: 104300  
    UniProtKB/Swiss-Prot: UROK_HUMAN, P00749
  • Quebec platelet disorder (QPD) [MIM:601709]: An autosomal dominant bleeding disorder due to a
    gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they
    show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased
    PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of
    alpha-granule proteins. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/175 diseases for PLAU (see all 175):    About MalaCards
    quebec platelet disorder    eosinophilic meningitis    conjunctivochalasis    sigmoid colon cancer
    paranasal sinus disease    colonic disease    dermatitis herpetiformis    pelvic inflammatory disease
    paroxysmal nocturnal hemoglobinuria    hemoglobinuria    factor xii deficiency    skeletal muscle regeneration
    ollier disease    septic arthritis    benign meningioma    pemphigus
    venous insufficiency    pancreatic cancer    pemphigus vulgaris    chronic venous leg ulcers

    8 diseases from the University of Copenhagen DISEASES database for PLAU:
    Breast cancer     Carcinoma     Prostate cancer     Ovarian cancer
    Colorectal cancer     Vascular disease     Lung cancer     Malignant glioma

    PLAU for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/98 Novoseek inferred disease relationships for PLAU gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 80.7 884 15150277 (5), 7866567 (5), 17264329 (4), 11410166 (4) (see all 99)
    quebec platelet disorder 80.3 13 19029443 (2), 12888877 (1), 18600101 (1), 15026313 (1) (see all 6)
    tumors 74.7 1838 11820719 (7), 10091785 (6), 14581368 (6), 10218628 (6) (see all 99)
    cancer 69.2 820 17923479 (7), 9815571 (5), 12168869 (5), 10091785 (5) (see all 99)
    breast cancer 68.9 747 17222367 (10), 15131040 (9), 11489825 (8), 17704550 (8) (see all 99)
    ovarian cancer 58.6 145 11410515 (4), 15653692 (3), 9194591 (3), 17611702 (3) (see all 66)
    fibrosarcoma 56.1 36 1901800 (2), 9164658 (2), 15033370 (2), 1652590 (1) (see all 21)
    prostate cancer 55.1 246 10221568 (7), 16127174 (5), 18439850 (5), 17571974 (4) (see all 83)
    cancer invasiveness 52.6 3 11079728 (1), 8162583 (1)
    breast carcinoma 52.4 73 15274061 (3), 8687092 (3), 9635840 (3), 11021826 (2) (see all 37)

    Genetic Association Database (GAD): PLAU
    Human Genome Epidemiology (HuGE) Navigator: PLAU (57 documents)

    Export disorders for PLAU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLAU gene, integrated from 9 sources (see all 2304):
    (articles sorted by number of sources associating them with PLAU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Persons with Quebec platelet disorder have a tandem d uplication of PLAU, the urokinase plasminogen activator gene. (PubMed id 20007542)1, 2, 4 Paterson A.D....Hayward C.P. (2010)
    2. Molecular cloning of cDNA coding for human preprourokinase. (PubMed id 2415429)1, 2, 3 Nagai M.... Suyama T. (1985)
    3. Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis. (PubMed id 17877801)1, 4, 9 Jessen K.M....Benfield T. (2007)
    4. Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. (PubMed id 15988036)1, 2, 9 Ustach C.V. and Kim H.-R.C. (2005)
    5. Antigen levels of the urokinase-type plasminogen activator and its gene polymorphisms in colorectal cancer. (PubMed id 12430175)1, 4, 9 Przybyl/owska K....Bl/asiak J. (2002)
    6. Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility. (PubMed id 10340997)1, 2, 9 He S....Liu Y.X. (1999)
    7. Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer. (PubMed id 9194591)1, 2, 9 Turkmen B.... Magdolen V. (1997)
    8. A C/T polymorphism in the urokinase-type plasminogen activator gene in colorectal cancer. (PubMed id 11876553)1, 4, 9 Przybylowska K....Pander B. (2001)
    9. Gene polymorphisms of fibrinolytic enzymes in coal workers' pneumoconiosis. (PubMed id 17649957)1, 4, 9 Chang L.C....Wu H.P. (2006)
    10. A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease. (PubMed id 16825285)1, 4, 9 Riemenschneider M....Kurz A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5328 HGNC: 9052 AceView: PLAU Ensembl:ENSG00000122861 euGenes: HUgn5328
    ECgene: PLAU Kegg: 5328 H-InvDB: PLAU

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLAU Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLAU Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Urokinase
    SeattleSNPshttp://pga.gs.washington.edu/data/plau/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLAU gene:
    Search GeneIP for patents involving PLAU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     EMD Millipore small molecules (inhibitor) for PLAU
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