Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLAGL2 Gene

Aliases for PLAGL2 Gene

  • PLAG1 Like Zinc Finger 2 2 3 5
  • Pleiomorphic Adenoma-Like Protein 2 3 4
  • Pleiomorphic Adenoma Gene-Like 2 2 3
  • C2H2-Type Zinc Finger Protein 2 3
  • Zinc Finger Protein PLAGL2 3
  • KIAA0198 4
  • ZNF900 3

External Ids for PLAGL2 Gene

Previous GeneCards Identifiers for PLAGL2 Gene

  • GC20M030568
  • GC20M031478
  • GC20M031525
  • GC20M030243
  • GC20M030780
  • GC20M027568

Summaries for PLAGL2 Gene

Entrez Gene Summary for PLAGL2 Gene

  • Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLAGL2 Gene

PLAGL2 (PLAG1 Like Zinc Finger 2) is a Protein Coding gene. Diseases associated with PLAGL2 include Adenoma and Pleomorphic Adenoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is PLAG1.

UniProtKB/Swiss-Prot for PLAGL2 Gene

  • Shows weak transcriptional activatory activity.

Gene Wiki entry for PLAGL2 Gene

Additional gene information for PLAGL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAGL2 Gene

Genomics for PLAGL2 Gene

Regulatory Elements for PLAGL2 Gene

Enhancers for PLAGL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H031709 2.1 FANTOM5 Ensembl ENCODE dbSUPER 33.9 +490.6 490603 14.7 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 TM9SF4 ASXL1 PLAGL2 MYLK2 COX4I2 DEFB121 RNU1-94P DEFB122 DEFB123 DEFB118
GH20H031601 2.3 VISTA FANTOM5 ENCODE dbSUPER 12.7 +600.3 600340 11.5 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D ASXL1 TM9SF4 MYLK2 COX4I2 HM13 RNU6-384P HM13-AS1 PLAGL2 POFUT1 ID1
GH20H031590 2 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +612.9 612943 8.5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 TM9SF4 HM13 ASXL1 PLAGL2 MCTS2P COX4I2 ID1 LOC105372588 RNU6-384P
GH20H032456 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -249.6 -249554 2.6 PKNOX1 ZNF76 KLF17 SIN3A BMI1 RAD21 GLIS2 ZNF366 ZNF143 EGR2 ASXL1 PLAGL2 KIF3B ENSG00000236772 GC20M032477
GH20H032254 1.5 Ensembl ENCODE dbSUPER 11.5 -48.6 -48579 2.8 PKNOX1 ATF1 FOXA2 ARID4B DMAP1 ATF7 FOS RUNX3 TSHZ1 MIER2 POFUT1 PLAGL2 TSPY26P NOL4L GC20P032252 KIF3B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLAGL2 on UCSC Golden Path with GeneCards custom track

Promoters for PLAGL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136102 91 1801 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for PLAGL2 Gene

Genomic Locations for PLAGL2 Gene
chr20:32,192,503-32,207,791
(GRCh38/hg38)
Size:
15,289 bases
Orientation:
Minus strand
chr20:30,780,306-30,795,594
(GRCh37/hg19)

Genomic View for PLAGL2 Gene

Genes around PLAGL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAGL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAGL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAGL2 Gene

Proteins for PLAGL2 Gene

  • Protein details for PLAGL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPG8-PLAL2_HUMAN
    Recommended name:
    Zinc finger protein PLAGL2
    Protein Accession:
    Q9UPG8
    Secondary Accessions:
    • A8K8T5
    • E1P5M3
    • Q92584

    Protein attributes for PLAGL2 Gene

    Size:
    496 amino acids
    Molecular mass:
    54584 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA12113.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PLAGL2 Gene

Post-translational modifications for PLAGL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLAGL2 Gene

No data available for DME Specific Peptides for PLAGL2 Gene

Domains & Families for PLAGL2 Gene

Gene Families for PLAGL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for PLAGL2 Gene

Suggested Antigen Peptide Sequences for PLAGL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPG8

UniProtKB/Swiss-Prot:

PLAL2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with PLAGL2: view

Function for PLAGL2 Gene

Molecular function for PLAGL2 Gene

UniProtKB/Swiss-Prot Function:
Shows weak transcriptional activatory activity.

Phenotypes From GWAS Catalog for PLAGL2 Gene

Gene Ontology (GO) - Molecular Function for PLAGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 15361364
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9722527
GO:0043565 sequence-specific DNA binding IDA 15361364
genes like me logo Genes that share ontologies with PLAGL2: view
genes like me logo Genes that share phenotypes with PLAGL2: view

Animal Models for PLAGL2 Gene

MGI Knock Outs for PLAGL2:

Animal Model Products

miRNA for PLAGL2 Gene

miRTarBase miRNAs that target PLAGL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAGL2 Gene

Localization for PLAGL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAGL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAGL2 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLAGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with PLAGL2: view

Pathways & Interactions for PLAGL2 Gene

SuperPathways for PLAGL2 Gene

No Data Available

SIGNOR curated interactions for PLAGL2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PLAGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006915 apoptotic process IBA --
genes like me logo Genes that share ontologies with PLAGL2: view

No data available for Pathways by source for PLAGL2 Gene

Drugs & Compounds for PLAGL2 Gene

(1) Drugs for PLAGL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PLAGL2: view

Transcripts for PLAGL2 Gene

mRNA/cDNA for PLAGL2 Gene

Unigene Clusters for PLAGL2 Gene

Pleiomorphic adenoma gene-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAGL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:

Relevant External Links for PLAGL2 Gene

GeneLoc Exon Structure for
PLAGL2
ECgene alternative splicing isoforms for
PLAGL2

Expression for PLAGL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLAGL2 Gene

Protein differential expression in normal tissues from HIPED for PLAGL2 Gene

This gene is overexpressed in Heart (53.7) and Prostate (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLAGL2 Gene



Protein tissue co-expression partners for PLAGL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLAGL2 Gene:

PLAGL2

SOURCE GeneReport for Unigene cluster for PLAGL2 Gene:

Hs.154104

Evidence on tissue expression from TISSUES for PLAGL2 Gene

  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with PLAGL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAGL2 Gene

Orthologs for PLAGL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLAGL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLAGL2 34 33
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PLAGL2 33 34
  • 95.77 (n)
cow
(Bos Taurus)
Mammalia PLAGL2 33 34
  • 94.96 (n)
mouse
(Mus musculus)
Mammalia Plagl2 34 16 33
  • 92.94 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLAGL2 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLAGL2 34
  • 84 (a)
OneToOne
LOC100859766 33
  • 77.78 (n)
lizard
(Anolis carolinensis)
Reptilia PLAGL2 34
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii plagl2 33
  • 64.66 (n)
plagx 34
  • 46 (a)
OneToOne
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG42726 34
  • 18 (a)
ManyToMany
CG2678 34
  • 15 (a)
ManyToMany
Species where no ortholog for PLAGL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAGL2 Gene

ENSEMBL:
Gene Tree for PLAGL2 (if available)
TreeFam:
Gene Tree for PLAGL2 (if available)

Paralogs for PLAGL2 Gene

Paralogs for PLAGL2 Gene

(6) SIMAP similar genes for PLAGL2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PLAGL2 Gene

genes like me logo Genes that share paralogs with PLAGL2: view

Variants for PLAGL2 Gene

Sequence variations from dbSNP and Humsavar for PLAGL2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000815784 -- 32,208,818(+) GTGAC(-/AG)AGTGA intron-variant, upstream-variant-2KB
rs1001055349 -- 32,202,757(+) GAGGT(A/G)CTAAG intron-variant
rs1001070770 -- 32,195,493(+) GTCAT(A/C)ATGTA utr-variant-3-prime
rs1001365600 -- 32,204,185(+) TCCCC(C/G)TTCAA intron-variant, upstream-variant-2KB
rs1001528768 -- 32,209,635(+) AGGAA(A/T)ATTGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLAGL2 Gene

Variant ID Type Subtype PubMed ID
nsv833954 CNV loss 17160897
nsv833953 CNV loss 17160897
nsv3349 CNV insertion 18451855

Variation tolerance for PLAGL2 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLAGL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAGL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAGL2 Gene

Disorders for PLAGL2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLAGL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adenoma
  • acinar cell adenoma
pleomorphic adenoma
  • mixed tumor of the salivary gland
gastrointestinal system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLAGL2

Genetic Association Database (GAD)
PLAGL2
Human Genome Epidemiology (HuGE) Navigator
PLAGL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLAGL2
genes like me logo Genes that share disorders with PLAGL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAGL2 Gene

Publications for PLAGL2 Gene

  1. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. (PMID: 15585652) Landrette SF … Castilla LH (Blood 2005) 2 3 22 60
  2. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. (PMID: 9722527) Kas K … Van de Ven WJ (The Journal of biological chemistry 1998) 3 4 22 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. (PMID: 19574421) Yang YS … Weissler JC (American journal of physiology. Lung cellular and molecular physiology 2009) 3 22 60
  5. Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation. (PMID: 18655774) Guo Y … Yang YS (Biochemical and biophysical research communications 2008) 3 22 60

Products for PLAGL2 Gene

Sources for PLAGL2 Gene

Content
Loading form....