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PLAGL2 Gene

protein-coding   GIFtS: 54

GC20M030243
pleiomorphic adenoma gene-like 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
FLJ23283 2
KIAA0198 3
OTTHUMP00000030585 2
Descriptions
C2H2-type zinc finger protein 2
Pleiomorphic adenoma-like protein 2 3
pleiomorphic adenoma gene-like 2 2
External Ids
HGNC: 90471
Entrez Gene: 53262
UniProtKB: Q9UPG83
Ensembl: ENSG000001260037
Search outside databases for aliases for PLAGL2 gene

Previous GC identifers: GC20M030568 GC20M031478 GC20M031525

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PLAGL2:
Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided
by RefSeq]

UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8
Function: Shows weak transcriptional activatory activity

Gene Wiki entry for PLAGL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PLAGL2 gene  

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

PLAGL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M030243:     (about GC identifiers)

Start:
30,243,968 bp from pter
End:
30,259,207 bp from pter
Size:
15,240 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000020.9  NT_028392.5  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8 (See protein sequence)
Recommended Name: Zinc finger protein PLAGL2  
Size: 496 amino acids; 54584 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q92584

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002648.1  

    ENSEMBL proteins: 
    ENSP00000246229 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (PLAGL2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IDA18029348
    About this table

    Antibodies for PLAGL2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PLAGL2
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (PLAGL2)
    Novus Biologicals Antibody for PLAGL2

    Assays for PLAGL2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2


       GeneDecks  PLAGL2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UPG8

    ProtoNet protein and cluster: Q9UPG8

    UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 6 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (PLAGL2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (PLAGL2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002657

                  Applied Biosystems Silencer® siRNAs for PLAGL2

                  Sigma-Aldrich siRNA for PLAGL2  
                         Sigma-Aldrich shRNA Panels and shRNA for PLAGL2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for PLAGL2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002657
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002657
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002657 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002657

    UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8
    Function: Shows weak transcriptional activatory activity

    4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plagl2):

    digestive/alimentarygrowth/sizehomeostasis/metabolismlethality-postnatal

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity TAS9722527
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  PLAGL2 


    5 Interacting proteins for PLAGL2 (ENSP000002462293) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCHY1ENSP000003212393STRING (score=.907)
    BNIP3ENSP000003576253STRING (score=.905)
    NCF2ENSP000003565053STRING (score=.895)
    POFUT1ENSP000003649023STRING (score=.868)
    KIF3BENSP000003648643STRING (score=.843)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0006917 induction of apoptosis IEA--
    GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for PLAGL2
    1 Novoseek chemical compound relationship for PLAGL2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 51.23 6 15361364 (1), 9722527 (1), 12667984 (1), 17332914 (1) (see all 5)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (PLAGL2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (PLAGL2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002657

                  Sigma-Aldrich siRNA for PLAGL2  
                         Sigma-Aldrich shRNA Panels and shRNA for PLAGL2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002657  

    REFSEQ mRNAs for PLAGL2 gene: 

    NM_002657.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002657  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002657
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002657
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002657 

    Additional cDNA sequence: 

    AF006005.1 AK026951.1 AK292450.1 BC023655.2 D83784.1 

    7 DOTS entries:

    DT.417611  DT.95088703  DT.120800443  DT.120800456  DT.91765246  DT.120800450  DT.121234278 

    24/187 AceView cDNA sequences (see all 187 ):

    AF006005 BG058670 BE251733 AA394124 CD365028 BI962708 AW008543 BU172561 
    AA643995 AA682460 AI458187 BX642593 AI346457 CA422973 BQ022795 CD364469 
    BM670311 BU186849 AI589651 CK903316 BE219645 AA574334 AA926710 AW964516 

    highest scoring ESTs for PLAGL2:

    D83784 AF006005 AL523896 AL526858 BC023655 BE251733 BE253711 BG684381 BI826943 BU160074 

    Unigene Cluster for PLAGL2:

    Pleiomorphic adenoma gene-like 2
    Hs.154104  [show with all ESTs]
    Unigene Representative Sequence: NM_002657


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PLAGL2

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                    -     -                                       
    SP2:                    -     -                                       
    SP3:                    -     -     -     -     -                     
    SP4:                          -                                       
    SP5:                                                                  

    About this scheme

    ECgene alternative splicing isoforms for PLAGL2

    1 Ensembl transcript including schematic representation:
    ENST00000246229  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    PLAGL2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for PLAGL2

    1 / 2 / 3

    5 probe-sets matching PLAGL2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    40061_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D83784 1.00 1.00 1.00 1

    202924_s_at2, 3 U133-A 1 1.00 1.00 -- -- AL562280 0.60 1.00 0.82 1

    202925_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002657 0.60 1.00 0.82 1

    202924_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202925_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.154104

    Expression variation in blood from EXPOLDB for PLAGL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for PLAGL2 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PLAGL21   -- pleiomorphic adenoma gene-like 2 95.77(n)
    98.99(a)
    485829  XM_542953.2  XP_542953.2 
    cow
    (Bos taurus)
    PLAGL21   -- pleiomorphic adenoma gene-like 2 94.96(n)
    97.78(a)
    522566  XM_600851.3  XP_600851.3 
    mouse
    (Mus musculus)
    Plagl21, 5 25
    pleiomorphic adenoma gene-like 21, 5 92.94(n)1
    98.59(a)1
    547111  NM_018807.51  NP_061277.21 
     AB0518545  AF1812625  (see all 25)
    zebrafish
    (Danio rerio)
    AF186476.12   --   -- 78.88(n) 259255  AF186476.1 
    About this table        Species with no ortholog for PLAGL2

    ENSEMBL Gene Tree for PLAGL2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for PLAGL2 gene
    PLAGL12  PLAG12  

    Pseudogenes
    1 related pseudogene


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/74 NCBI SNPs in PLAGL2 are shown (see all 74 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 38)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs10567761,2
    A,C,F,H,O30246204(-) CTCCAG/CTAGGG 1 -- ut31 ese34Minor allele frequency- C:0.39EU EA WA 418
    --
    rs60612161,2
    A,C,F,H30245774(+) CCATCG/ACCTAT 1 -- ut313Minor allele frequency- A:0.45MN EU WA 424
    rs60892091,2
    H30247477(+) AGGGCC/TTGACC 1 -- ut314Minor allele frequency- T:0.00EU EA WA 420
    rs124808051,2
    H30244876(+) TTGCAG/AGGAAC 1 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs61426351,2
    H30247320(+) TGTGTC/TTGAGG 1 -- ut314Minor allele frequency- T:0.00EU EA WA 418
    rs124798951,2
    H30244517(+) TGGGAT/ACCCAG 1 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 418
    --
    rs19230971,2
    F30253460(-) CTCCCG/ACAACC 1 P/P syn1 ese31Minor allele frequency- A:0.22MN 184
    rs7333201,2
    A,C,F,H,O30252723(+) CATCAC/ACTGAC 1 -- int19Minor allele frequency- A:0.43EU EA WA NA 736
    rs37873721,2
    A,C,F,H30255501(+) TTTAAG/CTCCCC 1 -- int19Minor allele frequency- C:0.28EA EU WA NA 2270
    rs60612241,2
    C,F,H30254325(+) TCTTAG/CCAGTG 1 -- int17Minor allele frequency- C:0.09EU EA WA NA 562
    About this table

    HapMap Linkage Disequilibrium images for PLAGL2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604866

    1 Novoseek disease relationship for PLAGL2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma pleomorphic 83.53 3 16207715 (1), 17618602 (1), 18655774 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/18 PubMed articles for PLAGL2 gene (see all 18 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 5326 HGNC: 9047 AceView: PLAGL2 Ensembl:ENSG00000126003 euGenes: HUgn5326
    ECgene: PLAGL2 H-InvDB: PLAGL2
    (According to HUGE)
    About This Section

    HUGE: KIAA0198
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for PLAGL2 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for PLAGL2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for PLAGL2 Antibodies for PLAGL2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for PLAGL2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Antibodies for PLAGL2

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