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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLAGL2 Gene

protein-coding   GIFtS: 53
GCID: GC20M030780

pleiomorphic adenoma gene-like 2

 Explore 9 diseases affiliated with
PLAGL2 via our new
 Human Malady Compendium 
Biological research products
for PLAGL2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Pleiomorphic Adenoma Gene-Like 21 2
ZNF9001 2
Pleiomorphic Adenoma-Like Protein 22 3
C2H2-Type Zinc Finger Protein2
Zinc Finger Protein PLAGL22
KIAA01983

External Ids:    HGNC: 90471   Entrez Gene: 53262   Ensembl: ENSG000001260037   OMIM: 6048665   UniProtKB: Q9UPG83   
ORGUL members:         
NONCODE:n342553    

Export aliases for PLAGL2 gene to outside databases

Previous GC identifers: GC20M030568 GC20M031478 GC20M031525 GC20M030243 GC20M027568


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLAGL2:
Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8
Function: Shows weak transcriptional activatory activity

Gene Wiki entry for PLAGL2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLAGL2 gene promoter:
         COUP-TF1   Sp1   Lmo2   COUP   HNF-4alpha2   CUTL1   RORalpha2   HNF-4alpha1   COUP-TF   c-Myb   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PLAGL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLAGL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

PLAGL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLAGL2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M030780:  view genomic region     (about GC identifiers)

Start:
30,780,306 bp from pter      End:
30,795,594 bp from pter
Size:
15,289 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8 (See protein sequence)
Recommended Name: Zinc finger protein PLAGL2  
Size: 496 amino acids; 54584 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA12113.1; Type=Erroneous initiation;
Secondary accessions: A8K8T5 E1P5M3 Q92584

Explore the universe of human proteins at neXtProt for PLAGL2: NX_Q9UPG8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UPG8

  • PLAGL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002648.1  
    ENSEMBL proteins: 
     ENSP00000246229  

    Human Recombinant Protein Products: 
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    Uscn Proteins for PLAGL2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    PLAGL2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PLAGL2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PLAGL2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UPG8

    ProtoNet protein and cluster: Q9UPG8

    UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 6 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8
    Function: Shows weak transcriptional activatory activity

    miRNA
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    miRTarBase miRNAs that target PLAGL2:
    hsa-let-7b (MIRT005038)

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    hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-759 hsa-miR-508-5p hsa-miR-761 hsa-miR-520b hsa-miR-224*
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAGL2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA15361364
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9722527
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IDA15361364


    PLAGL2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PLAGL2:
     Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Plagl2tm1Wjmv for PLAGL2
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plagl2):
     digestive/alimentary  growth/size  homeostasis/metabolism  mortality/aging 

    PLAGL2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLAGL2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for PLAGL2 (Q9UPG83 ENSP000002462294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCHY1Q96PM53, ENSP000003212394I2D: score=2 STRING: ENSP00000321239
    KAT5ENSP000003403304STRING: ENSP00000340330
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006629lipid metabolic process IEA--
    GO:0006917induction of apoptosis IEA--
    GO:0009791post-embryonic development IEA--
    GO:0034378chylomicron assembly IEA--


    PLAGL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLAGL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PLAGL2
    1 Novoseek chemical compound relationship for PLAGL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 53.7 7 15361364 (1), 9722527 (1), 12667984 (1), 17332914 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about PLAGL2 / PLAL2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLAGL2 gene: 
    NM_002657.3  

    Unigene Cluster for PLAGL2:

    Pleiomorphic adenoma gene-like 2
    Hs.154104  [show with all ESTs]
    Unigene Representative Sequence: NM_002657
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000246229(uc002wxn.2)

    miRNA
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    8/134 QIAGEN miScript miRNA Assays for microRNAs that regulate PLAGL2 (see all 134):
    hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-759 hsa-miR-508-5p hsa-miR-761 hsa-miR-520b hsa-miR-224*
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    Additional cDNA sequence: 

    AF006005.1 AK026951.1 AK292450.1 BC023655.2 D83784.1 

    7 DOTS entries:

    DT.417611  DT.95088703  DT.120800443  DT.120800456  DT.91765246  DT.120800450  DT.121234278 

    24/187 AceView cDNA sequences (see all 187):

    AI346457 BU186849 AF006005 AI589651 AA682460 AA394124 AA594776 BE251733 
    BX642593 BI962708 BG058670 BF593028 AI458187 BC023655 AW512962 AW008543 
    AA574334 CD364469 AA913384 AA926710 CK903316 CB853532 AA643995 BU161452 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PLAGL2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                    -     -                                       
    SP2:                    -     -                                       
    SP3:                    -     -     -     -     -                     
    SP4:                          -                                       
    SP5:                                                                  


    ECgene alternative splicing isoforms for PLAGL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLAGL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PLAGL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLAGL2

    SOURCE GeneReport for Unigene cluster: Hs.154104
        SABiosciences Expression via Pathway-Focused PCR Array including PLAGL2: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAGL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PLAGL2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008597661 zinc finger protein PLAGL2-like 78.32(n)
    86.18(a)
      100859766  XM_003642491.1  XP_003642539.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLAGL26
    --
    80(a)
    1 ↔ 1
    GL343505.1(445271-448645)
    zebrafish
    (Danio rerio)
    Actinopterygii AF186476.12   -- 78.88(n)   259255  AF186476.1 


    ENSEMBL Gene Tree for PLAGL2 (if available)
    TreeFam Gene Tree for PLAGL2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLAGL2 gene
    PLAGL12  PLAG12  
    6 SIMAP similar genes for PLAGL2 using alignment to 1 protein entry:     PLAL2_HUMAN:
    PLAGL1    PLAG1    ZNF702P    ZNF323    ZNF501    ZNF80

    PLAGL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PLAGL2
    PGOHUM00000245989


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/278 NCBI SNPs in PLAGL2 are shown (see all 278    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60612141,2
    --27568329(+) ttctgG/Tctggc 1 -- us2k10--------
    rs1924353151,2
    --30779954(+) GGAATA/GCTGAG 1 -- ds50010--------
    rs1457920391,2
    --30779995(+) CTAACC/TCAAAG 1 -- ds50010--------
    rs1400430771,2
    C,--30780067(+) TTTGG-/CTGT  
            
    CTGAC
    1 -- ds50010--------
    rs732523731,2
    C,F,--30780165(+) AGCTTA/GTAGGT 1 -- ds50014Minor allele frequency- G:0.34WA CSA 124
    rs739035061,2
    C,F,--30780176(+) GCTGAT/CGGGAG 1 -- ds50013Minor allele frequency- C:0.07WA CSA 122
    rs60612151,2
    --30780203(+) CCCTAC/TGCTCA 1 -- ds50013Minor allele frequency- T:0.06NA WA 122
    rs739035081,2
    C,F,--30780204(+) CCTACG/ACTCAC 1 -- ds50013Minor allele frequency- A:0.09WA CSA 122
    rs589809321,2
    C,F,--30780276(+) CAACCG/CTTTCC 1 -- ds50014Minor allele frequency- C:0.34WA CSA 124
    rs1481892661,2
    --30780341(+) AACTTA/CATTAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PLAGL2 (30780306 - 30795594 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PLAGL2
         1 CNV: 5132

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing PLAGL2:
    WNT Signaling
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLAGL2
    DNA2.0 Custom Variant and Variant Library Synthesis for PLAGL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PLAGL2 for disorders           About GeneDecksing

    OMIM gene information: 604866    OMIM disorders: --

    9 diseases for PLAGL2:    About MalaCards
    adenoma    dyserythropoietic anemia    congenital dyserythropoietic anemia    mixed cell type cancer
    pleomorphic adenoma    cell type cancer    anemia    emphysema
    hypoxia

    1 disease from the University of Copenhagen DISEASES database for PLAGL2:
    Pleomorphic adenoma

    1 Novoseek disease relationship for PLAGL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma pleomorphic 84.5 4 16207715 (1), 17618602 (1), 18655774 (1), 19574421 (1)

    Human Genome Epidemiology (HuGE) Navigator: PLAGL2 (1 document)

    Export disorders for PLAGL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLAGL2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with PLAGL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. (PubMed id 15585652)1, 3, 9 Landrette S.F....Castilla L.H. (2005)
    2. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. (PubMed id 9722527)1, 2, 9 Kas K.... Van de Ven W.J.M. (1998)
    3. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. (PubMed id 17950244)1, 3 Zheng G....Yang Y.C. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (1996)
    7. Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter. (PubMed id 15361364)1, 9 Yang M.C....Yang Y.S. (2005)
    8. PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cel l death/injury activity. (PubMed id 19574421)1, 9 Yang Y.S....Weissler J.C. (2009)
    9. Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation. (PubMed id 18655774)1, 9 Guo Y....Yang Y.S. (2008)
    10. PLAGL2 translocation and SP-C promoter activity--a cellular response of lung cells to hypoxia. (PubMed id 17618602)1, 9 Guo Y....Yang Y.S. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5326 HGNC: 9047 AceView: PLAGL2 Ensembl:ENSG00000126003 euGenes: HUgn5326
    ECgene: PLAGL2 H-InvDB: PLAGL2

    (According to HUGE)
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    HUGE: KIAA0198

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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