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Aliases for PLAGL2 Gene

Aliases for PLAGL2 Gene

  • PLAG1 Like Zinc Finger 2 2 3 5
  • Pleiomorphic Adenoma-Like Protein 2 3 4
  • Pleiomorphic Adenoma Gene-Like 2 2 3
  • C2H2-Type Zinc Finger Protein 2 3
  • KIAA0198 4
  • ZNF900 3

External Ids for PLAGL2 Gene

Previous GeneCards Identifiers for PLAGL2 Gene

  • GC20M030568
  • GC20M031478
  • GC20M031525
  • GC20M030243
  • GC20M030780
  • GC20M027568

Summaries for PLAGL2 Gene

Entrez Gene Summary for PLAGL2 Gene

  • Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLAGL2 Gene

PLAGL2 (PLAG1 Like Zinc Finger 2) is a Protein Coding gene. Diseases associated with PLAGL2 include adenoma and pleomorphic adenoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is PLAGL1.

UniProtKB/Swiss-Prot for PLAGL2 Gene

  • Shows weak transcriptional activatory activity.

Gene Wiki entry for PLAGL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAGL2 Gene

Genomics for PLAGL2 Gene

Regulatory Elements for PLAGL2 Gene

Promoters for PLAGL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLAGL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLAGL2 Gene

Chromosome:
20
Start:
32,192,503 bp from pter
End:
32,207,791 bp from pter
Size:
15,289 bases
Orientation:
Minus strand

Genomic View for PLAGL2 Gene

Genes around PLAGL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAGL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAGL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAGL2 Gene

Proteins for PLAGL2 Gene

  • Protein details for PLAGL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPG8-PLAL2_HUMAN
    Recommended name:
    Zinc finger protein PLAGL2
    Protein Accession:
    Q9UPG8
    Secondary Accessions:
    • A8K8T5
    • E1P5M3
    • Q92584

    Protein attributes for PLAGL2 Gene

    Size:
    496 amino acids
    Molecular mass:
    54584 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA12113.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PLAGL2 Gene

Proteomics data for PLAGL2 Gene at MOPED

Post-translational modifications for PLAGL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLAGL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLAGL2 Gene

Domains & Families for PLAGL2 Gene

Gene Families for PLAGL2 Gene

Protein Domains for PLAGL2 Gene

Suggested Antigen Peptide Sequences for PLAGL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPG8

UniProtKB/Swiss-Prot:

PLAL2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 6 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with PLAGL2: view

Function for PLAGL2 Gene

Molecular function for PLAGL2 Gene

UniProtKB/Swiss-Prot Function:
Shows weak transcriptional activatory activity.

Gene Ontology (GO) - Molecular Function for PLAGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IDA 15361364
genes like me logo Genes that share ontologies with PLAGL2: view
genes like me logo Genes that share phenotypes with PLAGL2: view

Animal Models for PLAGL2 Gene

MGI Knock Outs for PLAGL2:

Animal Model Products

miRNA for PLAGL2 Gene

miRTarBase miRNAs that target PLAGL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAGL2 Gene

Localization for PLAGL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLAGL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLAGL2 Gene COMPARTMENTS Subcellular localization image for PLAGL2 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for PLAGL2 Gene

Pathways & Interactions for PLAGL2 Gene

SuperPathways for PLAGL2 Gene

No Data Available

SIGNOR curated interactions for PLAGL2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PLAGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009791 post-embryonic development IEA --
GO:0034378 chylomicron assembly IEA,IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with PLAGL2: view

No data available for Pathways by source for PLAGL2 Gene

Drugs & Compounds for PLAGL2 Gene

(1) Drugs for PLAGL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PLAGL2: view

Transcripts for PLAGL2 Gene

Unigene Clusters for PLAGL2 Gene

Pleiomorphic adenoma gene-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLAGL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:

Relevant External Links for PLAGL2 Gene

GeneLoc Exon Structure for
PLAGL2
ECgene alternative splicing isoforms for
PLAGL2

Expression for PLAGL2 Gene

mRNA expression in normal human tissues for PLAGL2 Gene

Protein differential expression in normal tissues from HIPED for PLAGL2 Gene

This gene is overexpressed in Heart (53.7) and Prostate (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLAGL2 Gene



SOURCE GeneReport for Unigene cluster for PLAGL2 Gene Hs.154104

genes like me logo Genes that share expression patterns with PLAGL2: view

Protein tissue co-expression partners for PLAGL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PLAGL2 Gene

Orthologs for PLAGL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLAGL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLAGL2 35
  • 94.96 (n)
  • 97.78 (a)
PLAGL2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLAGL2 35
  • 95.77 (n)
  • 98.99 (a)
PLAGL2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plagl2 35
  • 92.94 (n)
  • 98.59 (a)
Plagl2 16
Plagl2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLAGL2 35
  • 99.73 (n)
  • 99.8 (a)
PLAGL2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLAGL2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859766 35
  • 77.78 (n)
  • 84.96 (a)
PLAGL2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLAGL2 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
plagl2 35
  • 64.66 (n)
  • 64.38 (a)
plagx 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2678 36
  • 15 (a)
ManyToMany
CG42726 36
  • 18 (a)
ManyToMany
Species with no ortholog for PLAGL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAGL2 Gene

ENSEMBL:
Gene Tree for PLAGL2 (if available)
TreeFam:
Gene Tree for PLAGL2 (if available)

Paralogs for PLAGL2 Gene

Paralogs for PLAGL2 Gene

(6) SIMAP similar genes for PLAGL2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PLAGL2 Gene

genes like me logo Genes that share paralogs with PLAGL2: view

Variants for PLAGL2 Gene

Sequence variations from dbSNP and Humsavar for PLAGL2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1056775 -- 32,196,354(-) CAGAG(A/C)TGGGT utr-variant-3-prime
rs1056776 -- 32,194,740(-) CTCCA(C/G)TAGGG utr-variant-3-prime
rs1056777 -- 32,193,381(-) GCCCA(A/G)CCTTT utr-variant-3-prime
rs1923096 -- 32,202,023(-) AATGG(A/G)GAGAA reference, synonymous-codon
rs1923097 -- 32,201,996(-) CTCCC(A/G)CAACC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PLAGL2 Gene

Variant ID Type Subtype PubMed ID
nsv833953 CNV Loss 17160897
nsv833954 CNV Loss 17160897
nsv3349 CNV Insertion 18451855

Variation tolerance for PLAGL2 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLAGL2 Gene

HapMap Linkage Disequilibrium report
PLAGL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAGL2 Gene

Disorders for PLAGL2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLAGL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adenoma
  • acinar cell adenoma
pleomorphic adenoma
  • mixed tumor of the salivary gland
gastrointestinal system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLAGL2

Genetic Association Database (GAD)
PLAGL2
Human Genome Epidemiology (HuGE) Navigator
PLAGL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLAGL2
genes like me logo Genes that share disorders with PLAGL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLAGL2 Gene

Publications for PLAGL2 Gene

  1. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. (PMID: 15585652) Landrette S.F. … Castilla L.H. (Blood 2005) 2 3 23 67
  2. PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. (PMID: 19574421) Yang Y.S. … Weissler J.C. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 23
  3. Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation. (PMID: 18655774) Guo Y. … Yang Y.S. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. (PMID: 17950244) Zheng G. … Yang Y.-C. (Biochem. Biophys. Res. Commun. 2007) 2 3
  5. PLAGL2 translocation and SP-C promoter activity--a cellular response of lung cells to hypoxia. (PMID: 17618602) Guo Y. … Yang Y.S. (Biochem. Biophys. Res. Commun. 2007) 3 23

Products for PLAGL2 Gene

Sources for PLAGL2 Gene

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