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PLAGL2 Gene

protein-coding   GIFtS: 53
GCID: GC20M030780

Pleiomorphic Adenoma Gene-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pleiomorphic Adenoma Gene-Like 21 2
C2H2-Type Zinc Finger Protein1 2
Pleiomorphic Adenoma-Like Protein 22 3
ZNF9002
Zinc Finger Protein PLAGL22
KIAA01983

External Ids:    HGNC: 90471   Entrez Gene: 53262   Ensembl: ENSG000001260037   OMIM: 6048665   UniProtKB: Q9UPG83   

Export aliases for PLAGL2 gene to outside databases

Previous GC identifers: GC20M030568 GC20M031478 GC20M031525 GC20M030243 GC20M027568


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLAGL2 Gene:
Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. (provided by RefSeq, Jul
2008)

GeneCards Summary for PLAGL2 Gene:
PLAGL2 (pleiomorphic adenoma gene-like 2) is a protein-coding gene. Diseases associated with PLAGL2 include mixed cell type cancer, and cell type cancer. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF768.

UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8
Function: Shows weak transcriptional activatory activity

Gene Wiki entry for PLAGL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLAGL2 gene promoter:
         COUP-TF1   Sp1   Lmo2   COUP   HNF-4alpha2   CUTL1   RORalpha2   HNF-4alpha1   COUP-TF   c-Myb   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PLAGL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLAGL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

PLAGL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLAGL2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M030780:  view genomic region     (about GC identifiers)

Start:
30,780,306 bp from pter      End:
30,795,594 bp from pter
Size:
15,289 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8 (See protein sequence)
Recommended Name: Zinc finger protein PLAGL2  
Size: 496 amino acids; 54584 Da
Sequence caution: Sequence=BAA12113.1; Type=Erroneous initiation;
Secondary accessions: A8K8T5 E1P5M3 Q92584

Explore the universe of human proteins at neXtProt for PLAGL2: NX_Q9UPG8

Explore proteomics data for PLAGL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PLAGL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002648.1  
    ENSEMBL proteins: 
     ENSP00000246229  

    PLAGL2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PLAGL2

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    PLAGL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR027775 C2H2_Znf_fam
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR027765 PLAG1/PLAGL2
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UPG8

    ProtoNet protein and cluster: Q9UPG8

    UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 6 C2H2-type zinc fingers


    PLAGL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLAL2_HUMAN, Q9UPG8
    Function: Shows weak transcriptional activatory activity

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA15361364
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9722527
    GO:0043565sequence-specific DNA binding IDA15361364
    GO:0046872metal ion binding IEA--
         
    PLAGL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PLAGL2:
     Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plagl2):
     digestive/alimentary  growth/size/body  homeostasis/metabolism  mortality/aging 

    PLAGL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Plagl2tm1Wjmv for PLAGL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLAGL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLAGL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLAGL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLAGL2

    miRNA
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    miRTarBase miRNAs that target PLAGL2:
    hsa-mir-215-5p (MIRT024808), hsa-mir-122-5p (MIRT023348), hsa-let-7b-5p (MIRT005038), hsa-mir-296-3p (MIRT038346), hsa-mir-24-3p (MIRT030604), hsa-mir-98-5p (MIRT027836), hsa-mir-192-5p (MIRT026801)

    Block miRNA regulation of human, mouse, rat PLAGL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLAGL2 (see all 134):
    hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-759 hsa-miR-508-5p hsa-miR-761 hsa-miR-520b hsa-miR-224*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLAGL2

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLAGL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAGL2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAGL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLAL2_HUMAN, Q9UPG8: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--

    PLAGL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including PLAGL2: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLAGL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PLAGL2 (Q9UPG83 ENSP000002462294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCHY1Q96PM53, ENSP000003212394I2D: score=2 STRING: ENSP00000321239
    KAT5ENSP000003403304STRING: ENSP00000340330
    DMRTC2ENSP000002699454STRING: ENSP00000269945
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process IEA--
    GO:0009791post-embryonic development IEA--
    GO:0034378chylomicron assembly IBA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter ----
    GO:2001244positive regulation of intrinsic apoptotic signaling pathway IEA--

    PLAGL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLAGL2 (PLAL2)

    1 Novoseek inferred chemical compound relationship for PLAGL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 53.7 7 15361364 (1), 9722527 (1), 12667984 (1), 17332914 (1) (see all 6)



    PLAGL2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PLAGL2 gene: 
    NM_002657.3  

    Unigene Cluster for PLAGL2:

    Pleiomorphic adenoma gene-like 2
    Hs.154104  [show with all ESTs]
    Unigene Representative Sequence: NM_002657
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000246229(uc002wxn.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat PLAGL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PLAGL2 (see all 134):
    hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-759 hsa-miR-508-5p hsa-miR-761 hsa-miR-520b hsa-miR-224*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLAGL2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLAGL2 (NM_002657)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLAGL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAGL2
    Primer
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    OriGene qPCR primer pairs and template standards for PLAGL2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLAGL2
      QuantiTect SYBR Green Assays in human, mouse, rat PLAGL2
      QuantiFast Probe-based Assays in human, mouse, rat PLAGL2

    Additional mRNA sequence: 

    AF006005.1 AK026951.1 AK292450.1 BC023655.2 D83784.1 

    7 DOTS entries:

    DT.417611  DT.95088703  DT.120800443  DT.120800456  DT.91765246  DT.120800450  DT.121234278 

    Selected AceView cDNA sequences (see all 187):

    AA594776 CB853532 AW008543 AA926710 AW512962 BU172561 BF593028 AA574334 
    CK903316 AA913384 BX642593 AI458187 CD365028 AA394124 BU186849 AA776441 
    BC023655 BM773349 AA682460 BQ431540 BU161452 BQ022795 AA643995 CD364469 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PLAGL2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                    -     -                                       
    SP2:                    -     -                                       
    SP3:                    -     -     -     -     -                     
    SP4:                          -                                       
    SP5:                                                                  


    ECgene alternative splicing isoforms for PLAGL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLAGL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PLAGL2 Expression
    About this image

    PLAGL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLAGL2 Protein Expression

    Genevestigator expression for PLAGL2

    SOURCE GeneReport for Unigene cluster: Hs.154104
        Pathway & Disease-focused RT2 Profiler PCR Array including PLAGL2: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAGL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLAGL2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plagl21 , 5 pleiomorphic adenoma gene-like 21, 5 92.94(n)1
    98.59(a)1
      2 (75.41 cM)5
    547111  NM_018807.51  NP_061277.21 
     1532277595 
    chicken
    (Gallus gallus)
    Aves LOC1008597661 zinc finger protein PLAGL2-like 77.78(n)
    84.96(a)
      100859766  XM_003642491.2  XP_003642539.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLAGL26
    pleiomorphic adenoma gene-like 2
    82(a)
    1 ↔ 1
    GL343505.1(445271-448730)
    zebrafish
    (Danio rerio)
    Actinopterygii AF186476.12   -- 78.88(n)   259255  AF186476.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG427266
    CG26786
    --
    18(a)
    15(a)
    many ↔ many
    many ↔ many
    3R(11173770-11176113)
    3R(3739579-3742272)


    ENSEMBL Gene Tree for PLAGL2 (if available)
    TreeFam Gene Tree for PLAGL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLAGL2 gene
    ZNF7682  PLAGL12  PLAG12  
    6 SIMAP similar genes for PLAGL2 using alignment to 1 protein entry:     PLAL2_HUMAN:
    PLAG1    PLAGL1    ZNF702P    ZNF323    ZNF501    ZNF80

    PLAGL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PLAGL2
    PGOHUM00000245989


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLAGL2 (see all 256)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732523731,2
    C,F--30780165(+) AGCTTA/GTAGGT 1 -- ds50014Minor allele frequency- G:0.34WA CSA 124
    rs739035061,2
    C,F--30780176(+) GCTGAT/CGGGAG 1 -- ds50013Minor allele frequency- C:0.07WA CSA 122
    rs60612151,2
    C,F--30780203(+) CCCTAC/TGCTCA 1 -- ds50013Minor allele frequency- T:0.06NA WA 122
    rs739035081,2
    C,F--30780204(+) CCTACG/ACTCAC 1 -- ds50013Minor allele frequency- A:0.09WA CSA 122
    rs589809321,2
    C,F--30780276(+) CAACCG/CTTTCC 1 -- ds50014Minor allele frequency- C:0.34WA CSA 124
    rs1481892661,2
    --30780341(+) AACTTA/CATTAT 1 -- ut310--------
    rs1404074431,2
    --30780359(+) TTTTTC/TTGAAA 1 -- ut310--------
    rs1848284211,2
    --30780433(+) TGGCAC/TTTATA 1 -- ut310--------
    rs61426341,2
    C,H--30780581(+) AAAGCC/TTTGAC 1 -- ut313Minor allele frequency- T:0.01NS NA 174
    rs1897494231,2
    --30780587(+) TTGACC/TGCTGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PLAGL2 (30780306 - 30795594 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PLAGL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3349CNV Insertion18451855
    nsv833954CNV Loss17160897
    nsv833953CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing PLAGL2:
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing PLAGL2
    DNA2.0 Custom Variant and Variant Library Synthesis for PLAGL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604866    OMIM disorders: --

    9 diseases for PLAGL2:    About MalaCards
    mixed cell type cancer    cell type cancer    adenoma    pleomorphic adenoma
    congenital dyserythropoietic anemia    hypoxia    acute myeloid leukemia    myeloid leukemia
    leukemia

    1 disease from the University of Copenhagen DISEASES database for PLAGL2:
    Pleomorphic adenoma

    PLAGL2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PLAGL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma pleomorphic 84.5 4 16207715 (1), 17618602 (1), 18655774 (1), 19574421 (1)

    Genetic Association Database (GAD): PLAGL2
    Human Genome Epidemiology (HuGE) Navigator: PLAGL2 (1 document)

    Export disorders for PLAGL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLAGL2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with PLAGL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. (PubMed id 15585652)1, 3, 9 Landrette S.F....Castilla L.H. (Blood 2005)
    2. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. (PubMed id 9722527)1, 2, 9 Kas K.... Van de Ven W.J.M. (J. Biol. Chem. 1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. (PubMed id 17950244)1, 3 Zheng G.... Yang Y.-C. (Biochem. Biophys. Res. Commun. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    8. Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter. (PubMed id 15361364)1, 9 Yang M.C....Yang Y.S. (Am. J. Respir. Cell Mol. Biol. 2005)
    9. PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. (PubMed id 19574421)1, 9 Yang Y.S....Weissler J.C. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009)
    10. Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation. (PubMed id 18655774)1, 9 Guo Y....Yang Y.S. (Biochem. Biophys. Res. Commun. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5326 HGNC: 9047 AceView: PLAGL2 Ensembl:ENSG00000126003 euGenes: HUgn5326
    ECgene: PLAGL2 H-InvDB: PLAGL2

    (According to HUGE)
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    HUGE: KIAA0198

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLAGL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLAGL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLAGL2 gene:
    Search GeneIP for patents involving PLAGL2

    GeneCards and IP:
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