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Aliases & Descriptions for PLAGL2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ23283 2 | | KIAA0198 3 | | OTTHUMP00000030585 2 |
| | | Descriptions |
|---|
| C2H2-type zinc finger protein 2 | | Pleiomorphic adenoma-like protein 2 3 | | pleiomorphic adenoma gene-like 2 2 |
|
| | Search outside databases for aliases for PLAGL2 genePrevious GC identifers: GC20M030568 GC20M031478 GC20M031525 |
Summaries for PLAGL2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PLAGL2: Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq] UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8Function: Shows weak transcriptional activatory activityGene Wiki entry for PLAGL2 |
Genomic Location for PLAGL2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PLAGL2 gene 
Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21PLAGL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M030243:
(about GC identifiers)
Start:
|
30,243,968 bp from pter |
End:
|
30,259,207 bp from pter |
Size:
|
15,240 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000020.9 NT_028392.5
| Proteins for PLAGL2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8 (See
protein sequence)Recommended Name: Zinc finger protein PLAGL2 Size: 496 amino acids; 54584 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q92584Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002648.1
ENSEMBL proteins: ENSP00000246229
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for PLAGL2: Assays for PLAGL2: | Protein
Domains/ Families for PLAGL2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UPG8
ProtoNet protein and cluster: Q9UPG8 UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 6 C2H2-type zinc fingers | Gene Function for PLAGL2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002657
Applied Biosystems Silencer® siRNAs for PLAGL2
Sigma-Aldrich siRNA for PLAGL2  Sigma-Aldrich shRNA Panels and shRNA for PLAGL2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002657                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002657                                  untagged cDNA clones in CMV expression vector (see all 2): NM_002657 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002657
UniProtKB/Swiss-Prot: PLAL2_HUMAN, Q9UPG8Function: Shows weak transcriptional activatory activity4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Plagl2):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for PLAGL2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for PLAGL2 
5 Interacting proteins for PLAGL2 (ENSP000002462293) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006917 | induction of apoptosis |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IEA | -- | About this table
|
Drugs & Compounds for PLAGL2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PLAGL2 1 Novoseek chemical compound relationship for PLAGL2 gene
About this table
|
Transcripts for PLAGL2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002657
Sigma-Aldrich siRNA for PLAGL2  Sigma-Aldrich shRNA Panels and shRNA for PLAGL2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002657 REFSEQ mRNAs for PLAGL2 gene: NM_002657.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002657               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002657                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002657                                  untagged cDNA clones in CMV expression vector (see all 2): NM_002657  Additional cDNA sequence: AF006005.1 AK026951.1 AK292450.1 BC023655.2 D83784.1 7 DOTS entries: DT.417611 DT.95088703 DT.120800443 DT.120800456 DT.91765246 DT.120800450 DT.121234278 24/187 AceView cDNA sequences (see all 187
):AF006005 BG058670 BE251733 AA394124 CD365028 BI962708 AW008543 BU172561 AA643995 AA682460 AI458187 BX642593 AI346457 CA422973 BQ022795 CD364469 BM670311 BU186849 AI589651 CK903316 BE219645 AA574334 AA926710 AW964516
highest scoring ESTs for PLAGL2:D83784 AF006005 AL523896 AL526858 BC023655 BE251733 BE253711 BG684381 BI826943 BU160074 Unigene Cluster for PLAGL2: Pleiomorphic adenoma gene-like 2 Hs.154104 [show with all ESTs]Unigene Representative Sequence: NM_002657
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for PLAGL2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for PLAGL2
1 Ensembl transcript including schematic representation: ENST00000246229
|
Expression for PLAGL2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PLAGL2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PLAGL2
1 / 2 / 3 5 probe-sets matching PLAGL2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.154104
Expression variation in blood from EXPOLDB for PLAGL2 |
Orthologs for PLAGL2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PLAGL2 gene from 4 species
About this table Species with no ortholog for PLAGL2
ENSEMBL Gene Tree for PLAGL2 | Paralogs for PLAGL2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PLAGL2 gene
- PLAGL12 PLAG12
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for PLAGL2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PLAGL2 (up to first 250kb)
|
Disorders & Mutations for PLAGL2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604866
1 Novoseek disease relationship for PLAGL2 gene
About this table
|
Medical News for PLAGL2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PLAGL2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for PLAGL2 gene (see all 18
):- Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. (PubMed id 15585652)1, 2, 3 Landrette S.F....Castilla L.H. (2005)
- Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. (PubMed id 9722527)1, 3, 4 Kas K.... Van de Ven W.J.M. (1998)
- PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. (PubMed id 17950244)2, 3 Zheng G....Yang Y.C. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)3, 4 Deloukas P....Rogers J. (2001)
- Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)3, 4 Nagase T....Nomura N. (1996)
- Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter. (PubMed id 15361364)1, 3 Yang M.C....Yang Y.S. (2005)
- Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation. (PubMed id 18655774)1, 3 Guo Y....Yang Y.S. (2008)
- PLAGL2 translocation and SP-C promoter activity--a cellular response of lung cells to hypoxia. (PubMed id 17618602)1, 3 Guo Y....Yang Y.S. (2007)
- Tip60 modulates PLAGL2-mediated transactivation by acetylation. (PubMed id 17551969)3 Ning J....Yang Y.C. (2008)
|
Search for PLAGL2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PLAGL2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PLAGL2
(According to HUGE)
About This Section
| |
Specialized Databases showing PLAGL2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PLAGL2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PLAGL2:

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Incremental update: 13 Oct 2009
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