PLAG1 Gene
protein-coding GIFtS: 56
GCID: GC08M057073
|
|
pleiomorphic adenoma gene 1
| |
Aliases
for PLAG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pleiomorphic Adenoma Gene 11 2 | | COL1A2/PLAG1 Fusion2 | | ZNF9121 2 | | Zinc Finger Protein PLAG12 | | PSA2 5 | | Pleiomorphic Adenoma Gene 1 Protein3 | | SGPA2 5 | | |
Export aliases for PLAG1 gene to outside databasesPrevious GC identifers: GC08M056256 GC08M057012 GC08M056796 GC08M057123 GC08M057236 GC08M052540 |
Summaries
for PLAG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PLAG1:
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which isdevelopmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivaryglands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary glandpleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PLAG1_HUMAN, Q6DJT9Function: Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading touncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformationare observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivarygland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed inhepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important formyeloid leukemia
Gene Wiki entry for PLAG1
|
Genomic Views
for PLAG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLAG1 gene promoter:
Pbx1a Nkx2-2 STAT3 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) HNF-3beta POU3F2 LyF-1 Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLAG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLAG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q12 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q12PLAG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M057073: view genomic region
(about GC identifiers)
Start:
|
57,073,463 bp from pter |
End:
|
57,123,883 bp from pter |
Size:
|
50,421 bases |
Orientation:
|
minus strand |
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Proteins
for PLAG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PLAG1_HUMAN, Q6DJT9 (See
protein sequence)Recommended Name: Zinc finger protein PLAG1 Size: 500 amino acids; 55909 Da
Subunit: Interacts with KPNA2, which escorts protein to the nucleus via interaction with nuclear localization signal.Interacts with E3 SUMO-protein ligase PIAS1, PIAS2 and PIAS4
Subcellular location: Nucleus. Note=Strong nucleolar localization when sumoylation is inhibited
Miscellaneous: Residual nuclear import after mutation of the nuclear localization signal is assigned to zinc fingerdomains of PLAG1
Miscellaneous: When cultured cells transformed by PLAG1 overexpression are injected in nude mouse, rapidly growingtumors (fibrosarcomaS) are observed at the site of inoculation
Sequence caution: Sequence=BAD92368.1; Type=Erroneous initiation;
Secondary accessions: B4DLC2 Q59GH8 Q9Y4L2Alternative splicing: 2 isoforms: Q6DJT9-1 Q6DJT9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PLAG1: NX_Q6DJT9
Post-translational modifications:
Sumoylated with SUMO1; which inhibits transcriptional activity, but does not affect nuclear localization. Blockers ofsumoylation pathway such as SENP3 and inactive UBE2I increases transcriptional capacity. Sumoylation is increased inthe presence of PIAS11
Acetylated by lysine acetyltransferase EP300; which activates transcriptional capacity. Lysine residues that aresumoylated also seem to be target for acetylation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6DJT9
PLAG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001108106.1 NP_001108107.1 NP_002646.2
ENSEMBL proteins: ENSP00000325546 ENSP00000404067 ENSP00000416537
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PLAG1 for ontologies About GeneDecksing
PLAG1 Antibody Products:
Assay Products for PLAG1: |
Protein
Domains /
Families
for PLAG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLAG1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6DJT9ProtoNet protein and cluster: Q6DJT9 UniProtKB/Swiss-Prot: PLAG1_HUMAN, Q6DJT9Domain: C2H2-type zinc fingers 3 interacts with DNA-binding site G-clusterinc fingers. C2H2-type zinc fingers 6 and 7interact with DNA-binding site core sequenceSimilarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 7 C2H2-type zinc fingers |
Function
for PLAG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PLAG1_HUMAN, Q6DJT9Function: Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading touncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformationare observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivarygland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed inhepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important formyeloid leukemia Genatlas biochemistry entry for PLAG1:putative pleomorphic adenoma gene 1,not normally expressed in adult tissues,fused with beta catenin in adenomas,withtranslocation t(3;8)(p21;q12),see ADPL,PSA2 and with TCEA1 t(3;8)(p21;q12) in salivary adenomas (see PSA2)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLAG1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLAG1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): PLAG1 (NM_002655) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLAG1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAG1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAG1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PLAG1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PLAG1:
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Plag1):
PLAG1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PLAG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLAG1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for PLAG1 (Q6DJT92, 3 ENSP000003255464) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0010628 | positive regulation of gene expression |
IEA | -- | | GO:0010629 | negative regulation of gene expression |
IEA | -- | | GO:0022612 | gland morphogenesis |
IEA | -- |
PLAG1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PLAG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PLAG1 for compounds About GeneDecksing
 Browse Tocris compounds for PLAG1
1 HMDB Compound for PLAG1 About this table
3 Novoseek chemical compound relationships for PLAG1 gene About this table
Search CenterWatch for drugs/clinical trials and news about PLAG1
|
Transcripts
for PLAG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PLAG1 gene (3 alternative transcripts): NM_001114634.1 NM_001114635.1 NM_002655.2 Unigene Cluster for PLAG1: Pleiomorphic adenoma gene 1 Hs.14968 [show with all ESTs]Unigene Representative Sequence: NM_0026555 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000316981(uc003xsq.4 uc003xsr.4 uc010lyi.3 uc010lyj.3)
ENST00000522009 ENST00000423799 ENST00000429357 ENST00000519027
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLAG1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLAG1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PLAG1 (NM_002655) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLAG1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAG1 |
Additional cDNA sequence: AB209131.1 AF221549.1 AF221550.1 AK296933.1 AK313663.1 BC075047.2 BC075048.2 EF525168.1 EF525169.1 EF525170.1 U65002.1 U78783.1 5 DOTS entries: DT.413427 DT.95109227 DT.75175426 DT.100741100 DT.100808133 24/48 AceView cDNA sequences (see all 48): AA706806 W23999 AA418372 BC075047 BF115791 BC075048 AA707386 AW339499 AA628501 BX402039 AA621141 CA411972 BF432133 CA413047 N79057 AI334157 NM_002655 AI873014 BX370812 AW002999 AA418251 BX424854 AI033382 U65002
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for PLAG1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PLAG1
|
Expression
for PLAG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PLAG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATCGTGT
About this image
See PLAG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLAG1
SOURCE GeneReport for Unigene cluster: Hs.14968
UniProtKB/Swiss-Prot: PLAG1_HUMAN, Q6DJT9Tissue specificity: Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normaladult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without8q12 abberations, with preferential occurrence in benign tumors
SABiosciences Custom PCR Arrays for PLAG1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLAG1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PLAG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLAG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLAG1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAG1 |
Orthologs
for PLAG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for PLAG1 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for PLAG1 (if available)
TreeFam Gene Tree for PLAG1 (if available) |
Paralogs
for PLAG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PLAG1 gene
- PLAGL12 PLAGL22
18/39 SIMAP similar genes for PLAG1 using alignment to 3 protein entries: PLAG1_HUMAN (see all proteins)
(see all similar genes):PLAGL1 A-328A3.4 PLAGL2 ZNF55 ZNF72 DKFZp434J0650
ZNF663 ZNF808 kr-znf3 ZNF78L1 ZNF DKFZp686O1631
ZNF702P DKFZp313M0722 DKFZp686N0199 ZFS-5 ZNF323 ZNF844
PLAG1 for paralogs About GeneDecksing
|
Genomic Variants
for PLAG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PLAG1 (57073463 - 57123883 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PLAG1
3 CNVs: 65142 37766 37569 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLAG1 |
|
Disorders
/ Diseases
for PLAG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PLAG1 for disorders About GeneDecksing
OMIM gene information: 603026
OMIM disorders: 181030
UniProtKB/Swiss-Prot: PLAG1_HUMAN, Q6DJT9
Note=A chromosomal aberration involving PLAG1 is found in salivary gland pleiomorphic adenomas, the mostcommon benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with constituvely expressedbeta-catenin/CTNNB1. Fusion occurs in the 5'-regulatory regions, leading to promoter swapping between the 2 genes andactivation of PLAG1 expression in adenomas. The chimeric transcript is formed by fusion of CTNNB1 exon 1 to PLAG1 exon3. Reciprocal fusion transcript consisting of PLAG1 exon 1 and CTNNB1 exon 2-16 is also revealed in some adenomas.Translocation t(3;8)(p21;q12) with transcription elongation factor SII/TCEA1. The fusion transcript is composed of5'-non-coding sequences as well as 63 nucleotides of the coding region of TCEA1 fused to the acceptor splice site ofPLAG1 exon 3. The fusion transcript encodes a truncated TCEA1-PLAG1 protein of 90 AA as well as an apparently normalPLAG1 protein. Reciprocal fusion transcript PLAG1-TCEA1 is also present in one adenoma. Translocation t(5;8)(p13;q12)with leukemia inhibitory factor receptor LIFR. This fusion occured in the 5'-non-coding sequences of both genes,exchanging regulatory control element while preserving the coding sequences. Translocation t(6;8)(p21.3-22;q13) withCoiled-coil-helix-coiled-coil-helix domain-containing protein 7/CHCHD7. Fusion occurs in the 5' regulatory regions,leading to promoter swapping and up-regulation of PLAG1 expression. Ectopic expression of PLAG1 under the control ofpromoters of distinct translocation partner genes is a general pathogenetic mechanism for pleiomorphic adenomas with8q aberrations. These fusion genes are likely to be found in adenomas with normal karyotype as this subgroup of tumorsalso exhibit PLAG1 activation Note=A chromosomal aberration involving PLAG1 may be a cause of lipoblastomas, which are benign tumorsresulting from transformation of adipocytes, usually diagnosed in children. 8q12.1 to 8q24.1 intrachromosomalrearrangement with hyaluronic acid synthase 2/HAS2 results in promoter swapping and activation of PLAG1 expression.The breakpoint of HAS2 gene is in PLAG1 intron 1, whereas its coding sequence starts at exon 2 or exon 3.Translocation t(7;8)(p22;q13) with collagen 1A2/COL1A2. Fusion transcript COL1A2-PLAG1 as well as HAS2-PLAG1 encode afull-length PLAG1 protein
20/31  diseases for PLAG1 (see all 31): About MalaCardspleomorphic adenoma adenoma adenomas, salivary gland pleomorphic atypical lipomatous tumor
salivary gland cancer ring chromosomes gastrointestinal stromal tumor mixed cell type cancer
angiomatosis salivary adenoma pleomorphic adenoma carcinoma lipoma
benign tumors myoepithelioma chronic lymphocytic leukemia acute myeloid leukemia
lymphocytic leukemia myeloid leukemia insulin resistance hepatoblastoma
5 diseases from the University of Copenhagen DISEASES database for PLAG1:Pleomorphic adenoma Adenoma Lipoma Vulvar leiomyoma
Liposarcoma 10/16 Novoseek disease relationships for PLAG1 gene (see all 16) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| salivary gland adenoma, pleomorphic |
93.9 |
5 |
16108035 (2), 10334569 (1), 15208321 (1), 15920557 (1) |
| adenoma pleomorphic |
89.9 |
57 |
15920557 (5), 11555676 (4), 16108035 (4), 18604193 (3) (see all 19) |
| lipoma |
60.7 |
2 |
17370328 (1), 18474299 (1) |
| hepatoblastoma |
57.9 |
3 |
14695992 (2), 17332914 (1) |
| benign tumor |
54.4 |
2 |
10029085 (1) |
| adenoma |
47.4 |
25 |
15920557 (4), 9088130 (2), 10646861 (2), 10029085 (1) (see all 8) |
| tumors |
42.5 |
58 |
10029085 (6), 18604193 (3), 15920557 (3), 16108035 (3) (see all 22) |
| chromosomal aberrations |
37.2 |
2 |
9268638 (1), 9722527 (1) |
| small cell lung cancer |
17.1 |
3 |
7559389 (2) |
| primary tumor |
14 |
1 |
10850459 (1) |
Human Genome Epidemiology (HuGE) Navigator: PLAG1 (4 documents)
Export disorders for PLAG1 gene to outside databases
|
Publications
for PLAG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PLAG1 gene, integrated from 9 sources (see all 95):
(articles sorted by number of sources associating them with PLAG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. (PubMed id 10029085)1, 2, 9 Astroem A.-K.... Stenman G. (1999)
- PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. (PubMed id 10646861)1, 2, 9 Voz M.L.... Kas K. (2000)
- Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation. (PubMed id 15208321)1, 2, 9 Van Dyck F.... Chavez M.V. (2004)
- The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter. (PubMed id 9525740)1, 2, 9 Voz M.L....Van de Ven W.J.M. (1998)
- CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. (PubMed id 16736500)1, 2, 9 Asp J.... Stenman G. (2006)
- Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. (PubMed id 9722527)1, 2, 9 Kas K.... Van de Ven W.J.M. (1998)
- PLAG1 fusion oncogenes in lipoblastoma. (PubMed id 10987300)1, 2, 9 Hibbard M.K....Fletcher J.A. (2000)
- Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. (PubMed id 9020842)1, 2, 9 Kas K....Van de Ven W.J.M. (1997)
- Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma. (PubMed id 14695992)1, 2, 9 Zatkova A.... Wimmer K. (2004)
- A 2-Mb YAC contig and physical map covering the chromosome 8q12 breakpoint cluster region in pleomorphic adenomas of the salivary glands. (PubMed id 9268638)1, 3, 9 Kas K....Van de Ven W.J. (1997)
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External Searches for PLAG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PLAG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PLAG1 gene
(According to HUGE)
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Specialized Databases showing PLAG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for PLAG1 gene:
Search GeneIP for patents involving PLAG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PLAG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PLAG1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLAG1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLAG1 | | | OriGene Protein Over-expression Lysate for PLAG1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PLAG1 | | OriGene 3'-UTR Clone for PLAG1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLAG1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLAG1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PLAG1 | | OriGene Custom Protein Services for PLAG1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLAG1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLAG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLAG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLAG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLAG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLAG1 |
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| | | | Search Tocris compounds for PLAG1 |
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 | | | PLAG1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAG1 |
|  |  |  | | | | Search ThermoFisher Antibodies for PLAG1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAG1 |
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