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Aliases for PLAC8L1 Gene

Aliases for PLAC8L1 Gene

  • PLAC8 Like 1 2 3 5

External Ids for PLAC8L1 Gene

Previous GeneCards Identifiers for PLAC8L1 Gene

  • GC05M145444
  • GC05M140610
  • GC05M145463

Summaries for PLAC8L1 Gene

GeneCards Summary for PLAC8L1 Gene

PLAC8L1 (PLAC8 Like 1) is a Protein Coding gene. An important paralog of this gene is CNFN.

Additional gene information for PLAC8L1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC8L1 Gene

Genomics for PLAC8L1 Gene

Regulatory Elements for PLAC8L1 Gene

Enhancers for PLAC8L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H145934 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.5 +163.3 163304 13 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS PLAC8L1 SH3RF2 GRXCR2 GC05P145976
GH05H146137 0.9 ENCODE 11.4 -33.9 -33878 1 ELF3 FOXA2 ARID4B RARA SCRT2 ATF7 CREM MIXL1 THAP11 PAF1 LARS PLAC8L1 RPL35AP16 RPL35AP17
GH05H146024 0.9 ENCODE 10.4 +77.4 77399 3 TBP FOXA2 KLF17 DMAP1 ZNF366 SCRT2 SMARCC2 RCOR1 FOS DEK LARS PLAC8L1 LOC100431175 GC05P146087
GH05H145948 0.8 ENCODE dbSUPER 9.5 +155.5 155489 1 MAFF ZNF316 MAFG EMSY MAFK PLAC8L1 SH3RF2 GRXCR2 GC05P145976
GH05H146076 0.6 ENCODE 12.4 +28.1 28111 0 HDAC1 OSR2 CTBP1 SOX6 FEZF1 CEBPG PLAC8L1 GRXCR2 GC05P146087 LOC100431175
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLAC8L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLAC8L1 Gene

146,084,149 bp from pter
146,104,383 bp from pter
20,235 bases
Minus strand

Genomic View for PLAC8L1 Gene

Genes around PLAC8L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAC8L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAC8L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC8L1 Gene

Proteins for PLAC8L1 Gene

  • Protein details for PLAC8L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PLAC8-like protein 1
    Protein Accession:

    Protein attributes for PLAC8L1 Gene

    177 amino acids
    Molecular mass:
    19885 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC8L1 Gene

Post-translational modifications for PLAC8L1 Gene

No Post-translational modifications

Other Protein References for PLAC8L1 Gene

No data available for DME Specific Peptides for PLAC8L1 Gene

Domains & Families for PLAC8L1 Gene

Gene Families for PLAC8L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PLAC8L1 Gene


Suggested Antigen Peptide Sequences for PLAC8L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cornifelin family.
  • Belongs to the cornifelin family.
genes like me logo Genes that share domains with PLAC8L1: view

Function for PLAC8L1 Gene

genes like me logo Genes that share phenotypes with PLAC8L1: view

Animal Model Products

CRISPR Products

miRNA for PLAC8L1 Gene

miRTarBase miRNAs that target PLAC8L1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PLAC8L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLAC8L1 Gene

Localization for PLAC8L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAC8L1 gene
Compartment Confidence
extracellular 2
peroxisome 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLAC8L1 Gene

Pathways & Interactions for PLAC8L1 Gene

SuperPathways for PLAC8L1 Gene

No Data Available

Interacting Proteins for PLAC8L1 Gene

Gene Ontology (GO) - Biological Process for PLAC8L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PLAC8L1 Gene

Drugs & Compounds for PLAC8L1 Gene

No Compound Related Data Available

Transcripts for PLAC8L1 Gene

mRNA/cDNA for PLAC8L1 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLAC8L1 Gene

PLAC8-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PLAC8L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC8L1 Gene

No ASD Table

Relevant External Links for PLAC8L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLAC8L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLAC8L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAC8L1 Gene

This gene is overexpressed in Testis (x14.0).

NURSA nuclear receptor signaling pathways regulating expression of PLAC8L1 Gene:


SOURCE GeneReport for Unigene cluster for PLAC8L1 Gene:

genes like me logo Genes that share expression patterns with PLAC8L1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAC8L1 Gene

Orthologs for PLAC8L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAC8L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLAC8L1 34 33
  • 98.68 (n)
(Bos Taurus)
Mammalia PLAC8L1 33 34
  • 86.06 (n)
(Rattus norvegicus)
Mammalia Plac8l1 33
  • 82.86 (n)
(Canis familiaris)
Mammalia PLAC8L1 34 33
  • 81.17 (n)
(Mus musculus)
Mammalia Plac8l1 34 16 33
  • 80.23 (n)
(Monodelphis domestica)
Mammalia PLAC8L1 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia PLAC8L1 34
  • 49 (a)
(Anolis carolinensis)
Reptilia PLAC8L1 34
  • 53 (a)
(Danio rerio)
Actinopterygii plac8l1 34 33
  • 59.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for PLAC8L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAC8L1 Gene

Gene Tree for PLAC8L1 (if available)
Gene Tree for PLAC8L1 (if available)

Paralogs for PLAC8L1 Gene

Paralogs for PLAC8L1 Gene

(2) SIMAP similar genes for PLAC8L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLAC8L1: view

Variants for PLAC8L1 Gene

Sequence variations from dbSNP and Humsavar for PLAC8L1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000013830 -- 146,101,165(+) GCATT(A/C)CAGCC intron-variant
rs1000082081 -- 146,100,852(+) ACTTA(A/G)GAAGT intron-variant
rs1000219849 -- 146,103,288(+) CCTAA(C/T)AGCTG intron-variant, upstream-variant-2KB
rs1000268930 -- 146,103,581(+) CCAGG(A/C)AAACC intron-variant, upstream-variant-2KB
rs1000352464 -- 146,090,344(+) GCCTG(G/T)CCAAC intron-variant

Variation tolerance for PLAC8L1 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLAC8L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLAC8L1 Gene

Disorders for PLAC8L1 Gene

Relevant External Links for PLAC8L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLAC8L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLAC8L1 Gene

Publications for PLAC8L1 Gene

  1. Common functions or only phylogenetically related? The large family of PLAC8 motif-containing/PCR genes. (PMID: 21347707) Song WY … Martinoia E (Molecules and cells 2011) 3 60
  2. Evolution of FW2.2-like (FWL) and PLAC8 genes in eukaryotes. (PMID: 20855956) Libault M … Stacey G (Plant signaling & behavior 2010) 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  5. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington JJ … Ducar M (Nature biotechnology 2001) 3 60

Products for PLAC8L1 Gene

Sources for PLAC8L1 Gene

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