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Aliases for PLAC8 Gene

Aliases for PLAC8 Gene

  • Placenta Specific 8 2 3 5
  • Down-Regulated In Gastrointestinal Cancer Protein 3
  • Placenta-Specific 8 3
  • Protein C15 4
  • PNAS-144 3
  • Onzin 3
  • DGIC 3
  • C15 3

External Ids for PLAC8 Gene

Previous GeneCards Identifiers for PLAC8 Gene

  • GC04M083935
  • GC04M084305
  • GC04M084469
  • GC04M084368
  • GC04M079752

Summaries for PLAC8 Gene

GeneCards Summary for PLAC8 Gene

PLAC8 (Placenta Specific 8) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism and Gastric cancer network 2. GO annotations related to this gene include chromatin binding. An important paralog of this gene is PLAC8L1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC8 Gene

Genomics for PLAC8 Gene

Regulatory Elements for PLAC8 Gene

Enhancers for PLAC8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLAC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLAC8 Gene

83,090,048 bp from pter
83,137,075 bp from pter
47,028 bases
Minus strand

Genomic View for PLAC8 Gene

Genes around PLAC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC8 Gene

Proteins for PLAC8 Gene

  • Protein details for PLAC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Placenta-specific gene 8 protein
    Protein Accession:
    Secondary Accessions:
    • C1K3N2

    Protein attributes for PLAC8 Gene

    115 amino acids
    Molecular mass:
    12507 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC8 Gene

Proteomics data for PLAC8 Gene at MOPED

Post-translational modifications for PLAC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLAC8 Gene

No data available for DME Specific Peptides for PLAC8 Gene

Domains & Families for PLAC8 Gene

Protein Domains for PLAC8 Gene


Suggested Antigen Peptide Sequences for PLAC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cornifelin family.
  • Belongs to the cornifelin family.
genes like me logo Genes that share domains with PLAC8: view

No data available for Gene Families for PLAC8 Gene

Function for PLAC8 Gene

genes like me logo Genes that share phenotypes with PLAC8: view

Animal Models for PLAC8 Gene

MGI Knock Outs for PLAC8:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLAC8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAC8 Gene

Localization for PLAC8 Gene

Subcellular locations from

Jensen Localization Image for PLAC8 Gene COMPARTMENTS Subcellular localization image for PLAC8 gene
Compartment Confidence
extracellular 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLAC8 Gene

Pathways & Interactions for PLAC8 Gene

genes like me logo Genes that share pathways with PLAC8: view

Pathways by source for PLAC8 Gene

1 Cell Signaling Technology pathway for PLAC8 Gene
1 BioSystems pathway for PLAC8 Gene

Gene Ontology (GO) - Biological Process for PLAC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0040015 negative regulation of multicellular organism growth IEA --
GO:0042742 defense response to bacterium IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with PLAC8: view

No data available for SIGNOR curated interactions for PLAC8 Gene

Drugs & Compounds for PLAC8 Gene

No Compound Related Data Available

Transcripts for PLAC8 Gene

Unigene Clusters for PLAC8 Gene

Placenta-specific 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC8 Gene

No ASD Table

Relevant External Links for PLAC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLAC8 Gene

mRNA expression in normal human tissues for PLAC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAC8 Gene

This gene is overexpressed in Whole Blood (x21.4) and Colon - Transverse (x5.9).

Protein differential expression in normal tissues from HIPED for PLAC8 Gene

This gene is overexpressed in Blymphocyte (36.4), NK cells (23.1), and Colon (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLAC8 Gene

SOURCE GeneReport for Unigene cluster for PLAC8 Gene Hs.546392

mRNA Expression by UniProt/SwissProt for PLAC8 Gene

Tissue specificity: Expressed at high levels in plasmacytoid dendritic cells. High expression in spleen, lymph nodes, peripheral blood leukocytes, and bone marrow, with lower expression in thymus, appendix, and fetal liver.
genes like me logo Genes that share expression patterns with PLAC8: view

Protein tissue co-expression partners for PLAC8 Gene

Primer Products

Orthologs for PLAC8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC100685470 35
  • 88.5 (n)
  • 89.38 (a)
PLAC8 36
  • 66 (a)
(Mus musculus)
Mammalia Plac8 35
  • 81.68 (n)
  • 84.68 (a)
Plac8 16
Plac8 36
  • 84 (a)
(Pan troglodytes)
Mammalia PLAC8 35
  • 100 (n)
  • 100 (a)
PLAC8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Plac8 35
  • 80.48 (n)
  • 84.68 (a)
(Bos Taurus)
Mammalia PLAC8 36
  • 87 (a)
(Monodelphis domestica)
Mammalia PLAC8 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia PLAC8 36
  • 69 (a)
(Gallus gallus)
Aves PLAC8 35
  • 63.21 (n)
  • 66.98 (a)
PLAC8 36
  • 64 (a)
(Anolis carolinensis)
Reptilia PLAC8 36
  • 72 (a)
(Danio rerio)
Actinopterygii plac8.1 36
  • 48 (a)
plac8.2 36
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for PLAC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAC8 Gene

Gene Tree for PLAC8 (if available)
Gene Tree for PLAC8 (if available)

Paralogs for PLAC8 Gene

Paralogs for PLAC8 Gene

(2) SIMAP similar genes for PLAC8 Gene using alignment to 3 proteins: Pseudogenes for PLAC8 Gene

genes like me logo Genes that share paralogs with PLAC8: view

Variants for PLAC8 Gene

Sequence variations from dbSNP and Humsavar for PLAC8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1987007 -- 83,094,147(-) ATATA(G/T)AATTA intron-variant, downstream-variant-500B
rs2868728 -- 83,099,565(-) tttgg(G/T)tgggg intron-variant
rs2868732 -- 83,093,457(+) TATTA(C/T)GCCAT intron-variant
rs2868733 -- 83,094,296(+) TTTTC(G/T)TTACT intron-variant, utr-variant-3-prime
rs3792715 -- 83,092,364(-) TTAAT(A/C)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLAC8 Gene

Variant ID Type Subtype PubMed ID
nsv829990 CNV Gain 17160897
nsv522237 CNV Gain 19592680
esv2727897 CNV Deletion 23290073
dgv893e201 CNV Deletion 23290073
esv2727899 CNV Deletion 23290073
nsv829991 CNV Loss 17160897

Variation tolerance for PLAC8 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLAC8 Gene

Disorders for PLAC8 Gene

Relevant External Links for PLAC8

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLAC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLAC8 Gene

Publications for PLAC8 Gene

  1. Subtractive hybridization reveals the expression of immunoglobulin like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. (PMID: 12384430) Rissoan M.-C. … Bates E.E.M. (Blood 2002) 2 3 4 67
  2. Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis. (PMID: 12758124) Galaviz-Hernandez C. … Nagaraja R. (Gene 2003) 2 3
  3. Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus. (PMID: 25720387) Blue E.K. … Haneline L.S. (Diabetes 2015) 3
  4. Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. (PMID: 24691442) Li C. … Coffey R.J. (J. Clin. Invest. 2014) 3
  5. Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression. (PMID: 24794439) Kinsey C. … Land H. (Cell Rep 2014) 3

Products for PLAC8 Gene

Sources for PLAC8 Gene