Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLAC8 Gene

Aliases for PLAC8 Gene

  • Placenta Specific 8 2 3 5
  • Down-Regulated In Gastrointestinal Cancer Protein 3
  • Placenta-Specific Gene 8 Protein 3
  • Protein C15 4
  • PNAS-144 3
  • Onzin 3
  • DGIC 3
  • C15 3

External Ids for PLAC8 Gene

Previous GeneCards Identifiers for PLAC8 Gene

  • GC04M083935
  • GC04M084305
  • GC04M084469
  • GC04M084368
  • GC04M079752

Summaries for PLAC8 Gene

GeneCards Summary for PLAC8 Gene

PLAC8 (Placenta Specific 8) is a Protein Coding gene. Among its related pathways are Innate Immune System and Differentiation of white and brown adipocyte. GO annotations related to this gene include chromatin binding. An important paralog of this gene is CNFN.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLAC8 Gene

Genomics for PLAC8 Gene

Regulatory Elements for PLAC8 Gene

Enhancers for PLAC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G083197 1.6 FANTOM5 Ensembl ENCODE dbSUPER 41.1 -61.0 -61027 2.2 ZNF146 CEBPB CEBPG ZNF644 TBX21 RARA ZNF507 TCF12 EED IKZF1 PLAC8 THAP9 HPSE COQ2 GC04M083225
GH04G083170 1.6 FANTOM5 Ensembl ENCODE dbSUPER 34.2 -34.3 -34343 1.4 ELF3 SOX13 CEBPG ZNF644 RARA YY1 NCOR1 ZNF547 NR2F6 HOMEZ PLAC8 THAP9 MRPS18C HPSE COQ2 GC04M083225
GH04G083215 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28.8 -81.1 -81094 4.7 PKNOX1 BMI1 YBX1 RAD21 CBX5 ZNF143 ZNF207 RELB ETV6 IKZF2 PLAC8 LOC391674 THAP9 HPSE COQ2 LIN54 HELQ GC04M083225
GH04G083230 1.6 FANTOM5 Ensembl ENCODE dbSUPER 30.4 -94.7 -94734 2.1 CTCF TBL1XR1 CEBPG RAD21 RELA EED ETV6 RELB IKZF2 MTA2 PLAC8 LOC391674 THAP9 HPSE COQ2 GC04M083232 GC04M083225
GH04G083180 1.6 FANTOM5 Ensembl ENCODE dbSUPER 29.7 -43.5 -43546 0.9 TBL1XR1 RELA ARID3A EED ZSCAN29 RELB IKZF2 MTA2 NR2F1 TRIM22 PLAC8 THAP9 HPSE COQ2 LIN54 GC04M083225
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLAC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLAC8 Gene

Chromosome:
4
Start:
83,090,048 bp from pter
End:
83,137,075 bp from pter
Size:
47,028 bases
Orientation:
Minus strand

Genomic View for PLAC8 Gene

Genes around PLAC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLAC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLAC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLAC8 Gene

Proteins for PLAC8 Gene

  • Protein details for PLAC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZF1-PLAC8_HUMAN
    Recommended name:
    Placenta-specific gene 8 protein
    Protein Accession:
    Q9NZF1
    Secondary Accessions:
    • C1K3N2

    Protein attributes for PLAC8 Gene

    Size:
    115 amino acids
    Molecular mass:
    12507 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLAC8 Gene

Post-translational modifications for PLAC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLAC8 Gene

No data available for DME Specific Peptides for PLAC8 Gene

Domains & Families for PLAC8 Gene

Protein Domains for PLAC8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLAC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZF1

UniProtKB/Swiss-Prot:

PLAC8_HUMAN :
  • Belongs to the cornifelin family.
Family:
  • Belongs to the cornifelin family.
genes like me logo Genes that share domains with PLAC8: view

No data available for Gene Families for PLAC8 Gene

Function for PLAC8 Gene

Gene Ontology (GO) - Molecular Function for PLAC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with PLAC8: view
genes like me logo Genes that share phenotypes with PLAC8: view

Animal Models for PLAC8 Gene

MGI Knock Outs for PLAC8:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLAC8

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLAC8 Gene

Localization for PLAC8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLAC8 gene
Compartment Confidence
extracellular 5
lysosome 4

Gene Ontology (GO) - Cellular Components for PLAC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0035578 azurophil granule lumen TAS --
genes like me logo Genes that share ontologies with PLAC8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLAC8 Gene

Pathways & Interactions for PLAC8 Gene

genes like me logo Genes that share pathways with PLAC8: view

Pathways by source for PLAC8 Gene

1 Cell Signaling Technology pathway for PLAC8 Gene
3 Reactome pathways for PLAC8 Gene

Interacting Proteins for PLAC8 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309509%0d%0a9606.ENSP00000298838%0d%0a9606.ENSP00000350359%0d%0a9606.ENSP00000269305%0d%0a
Selected Interacting proteins: Q9NZF1-PLAC8_HUMAN ENSP00000309509 for PLAC8 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PLAC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0009409 response to cold IEA --
GO:0040015 negative regulation of multicellular organism growth IEA --
GO:0042742 defense response to bacterium IEA --
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with PLAC8: view

No data available for SIGNOR curated interactions for PLAC8 Gene

Drugs & Compounds for PLAC8 Gene

No Compound Related Data Available

Transcripts for PLAC8 Gene

Unigene Clusters for PLAC8 Gene

Placenta-specific 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLAC8 Gene

No ASD Table

Relevant External Links for PLAC8 Gene

GeneLoc Exon Structure for
PLAC8
ECgene alternative splicing isoforms for
PLAC8

Expression for PLAC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLAC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLAC8 Gene

This gene is overexpressed in Whole Blood (x21.4) and Colon - Transverse (x5.9).

Protein differential expression in normal tissues from HIPED for PLAC8 Gene

This gene is overexpressed in Blymphocyte (36.4), NK cells (23.1), and Colon (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLAC8 Gene



Protein tissue co-expression partners for PLAC8 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLAC8 Gene:

PLAC8

SOURCE GeneReport for Unigene cluster for PLAC8 Gene:

Hs.546392

mRNA Expression by UniProt/SwissProt for PLAC8 Gene:

Q9NZF1-PLAC8_HUMAN
Tissue specificity: Expressed at high levels in plasmacytoid dendritic cells. High expression in spleen, lymph nodes, peripheral blood leukocytes, and bone marrow, with lower expression in thymus, appendix, and fetal liver.

Evidence on tissue expression from TISSUES for PLAC8 Gene

  • Spleen(4.5)
  • Blood(4.4)
  • Bone marrow(4.4)
  • Lymph node(4.3)
  • Intestine(2.4)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with PLAC8: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLAC8 Gene

Orthologs for PLAC8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLAC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLAC8 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia LOC100685470 34
  • 88.5 (n)
PLAC8 35
  • 66 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLAC8 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plac8 34 16 35
  • 81.68 (n)
rat
(Rattus norvegicus)
Mammalia Plac8 34
  • 80.48 (n)
oppossum
(Monodelphis domestica)
Mammalia PLAC8 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLAC8 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLAC8 34 35
  • 63.21 (n)
lizard
(Anolis carolinensis)
Reptilia PLAC8 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii plac8.1 35
  • 48 (a)
OneToMany
plac8.2 35
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for PLAC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLAC8 Gene

ENSEMBL:
Gene Tree for PLAC8 (if available)
TreeFam:
Gene Tree for PLAC8 (if available)

Paralogs for PLAC8 Gene

Paralogs for PLAC8 Gene

(2) SIMAP similar genes for PLAC8 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PLAC8 Gene

genes like me logo Genes that share paralogs with PLAC8: view

Variants for PLAC8 Gene

Sequence variations from dbSNP and Humsavar for PLAC8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000126862 -- 83,107,880(+) CCGAC(A/T)CCAGG reference, synonymous-codon
rs1000132028 -- 83,093,697(+) TGAAT(C/T)CTGCA intron-variant, downstream-variant-500B
rs1000155333 -- 83,115,973(+) CAGAC(-/ATG)GTGGT upstream-variant-2KB
rs1000196018 -- 83,109,351(+) AAAAT(A/G)TACCA intron-variant
rs1000457954 -- 83,098,398(+) AAAAT(A/G)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLAC8 Gene

Variant ID Type Subtype PubMed ID
dgv328e215 CNV deletion 23714750
dgv846e201 CNV deletion 23290073
esv2727897 CNV deletion 23290073
esv2727899 CNV deletion 23290073
esv3564157 CNV deletion 23714750
esv3893971 CNV gain 25118596
nsv1136883 CNV deletion 24896259
nsv522237 CNV gain 19592680
nsv829990 CNV gain 17160897
nsv829991 CNV loss 17160897
nsv950349 CNV duplication 24416366

Variation tolerance for PLAC8 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLAC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLAC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLAC8 Gene

Disorders for PLAC8 Gene

Relevant External Links for PLAC8

Genetic Association Database (GAD)
PLAC8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLAC8

No disorders were found for PLAC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLAC8 Gene

Publications for PLAC8 Gene

  1. Subtractive hybridization reveals the expression of immunoglobulin like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. (PMID: 12384430) Rissoan M.-C. … Bates E.E.M. (Blood 2002) 2 3 4 64
  2. Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis. (PMID: 12758124) Galaviz-Hernandez C. … Nagaraja R. (Gene 2003) 2 3 64
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  4. PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways. (PMID: 26669866) Kaistha B.P. … Buchholz M. (Cancer Res. 2016) 3 64
  5. Down-regulated PLAC8 promotes hepatocellular carcinoma cell proliferation by enhancing PI3K/Akt/GSK3I^/Wnt/I^-catenin signaling. (PMID: 27643556) Zou L. … Du J.J. (Biomed. Pharmacother. 2016) 3 64

Products for PLAC8 Gene

Sources for PLAC8 Gene

Content
Loading form....