PLAC4 Gene
protein-coding GIFtS: 35
GCID: GC21M042547
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placenta-specific 4(Previous name: chromosome 21 open reading frame 115 )
(Previous symbol: C21orf115)
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Aliases
for PLAC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Placenta-Specific 41 2 | | MGC1266661 | | C21orf1151 2 3 | | Chromosome 21 Open Reading Frame 1151 | | PRED781 2 | | Placenta-Specific Protein 42 | | MGC1266641 | | D21S418E3 |
Export aliases for PLAC4 gene to outside databasesPrevious GC identifers: GC21U990111 GC21M041469 GC21M041470 |
Summaries
for PLAC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PLAC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLAC4 gene promoter:
C/EBPbeta NCX/Ncx Lmo2 Nkx2-5 GATA-1 Evi-1 C/EBPalpha HSF2 FOXO4 Sox9
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLAC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLAC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.2 Ensembl cytogenetic band: 21q22.2 HGNC chromosome: 21PLAC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M042547: view genomic region
(about GC identifiers)
Start:
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42,547,158 bp from pter |
End:
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42,558,715 bp from pter |
Size:
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11,558 bases |
Orientation:
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minus strand |
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Proteins
for PLAC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PLAC4_HUMAN, Q8WY50 (See
protein sequence)Recommended Name: Placenta-specific protein 4 Size: 150 amino acids; 16680 DaExplore the universe of human proteins at neXtProt for PLAC4: NX_Q8WY50
PLAC4 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_878252.2
Human Recombinant Protein Products:
PLAC4 Antibody Products:
Assay Products for PLAC4: |
Protein
Domains /
Families
for PLAC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8WY50 |
Function
for PLAC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLAC4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLAC4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PLAC4 (NM_182832) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLAC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAC4 |
1 GenomeRNAi human phenotype for PLAC4:
|
Pathways & Interactions
for PLAC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLAC4
|
Drugs & Compounds
for PLAC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PLAC4
Search CenterWatch for drugs/clinical trials and news about PLAC4
|
Transcripts
for PLAC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PLAC4 gene: NM_182832.2 Unigene Cluster for PLAC4: Placenta-specific 4 Hs.472492 [show with all ESTs]Unigene Representative Sequence: NM_1828324 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000430327 ENST00000440221 ENST00000414699 ENST00000536486
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLAC4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLAC4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PLAC4 (NM_182832) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PLAC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAC4 |
Additional cDNA sequence: AF269287.1 AK027868.1 BC093685.1 BC101615.1 BC101617.1 L13197.1 14 DOTS entries: DT.95074502 DT.95265783 DT.453893 DT.121129190 DT.100824980 DT.95265781 DT.100824988 DT.121129260 DT.121129072 DT.95151295 DT.95265780 DT.121129064 DT.121424212 DT.92414622 24/363 AceView cDNA sequences (see all 363): AU140658 BU752109 BX364825 CF527838 AU140499 CB989724 BQ022372 AU140374 AU136651 AA367766 BX356877 BQ026587 AI149439 CB988938 CR607889 R74596 AA368159 BQ022361 BQ230113 N29322 BQ022365 N29636 BX361271 AU139502
GeneLoc Exon Structure
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Expression
for PLAC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PLAC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for PLAC4
SOURCE GeneReport for Unigene cluster: Hs.472492
UniProtKB/Swiss-Prot: PLAC4_HUMAN, Q8WY50Tissue specificity: Expressed in placental syncytiotrophoblast and choriocarcinoma cells
SABiosciences Custom PCR Arrays for PLAC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLAC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PLAC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLAC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLAC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAC4 |
Orthologs
for PLAC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for PLAC4 (if available)
TreeFam Gene Tree for PLAC4 (if available) |
Paralogs
for PLAC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PLAC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PLAC4
1 Inversion: 37236 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for PLAC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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PLAC4 for disorders About GeneDecksing
OMIM gene information: 613770
OMIM disorders: --
1  disease for PLAC4: About MalaCardschoriocarcinoma
Human Genome Epidemiology (HuGE) Navigator: PLAC4 (3 documents)
Export disorders for PLAC4 gene to outside databases
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Publications
for PLAC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PLAC4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PLAC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells. (PubMed id 8406465)1, 2 Kido S.... Strauss J.F. III (1993)
- Synergy of total PLAC4 RNA concentration and measurem ent of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21. (PubMed id 19892844)1, 9 Tsui N.B....Lo Y.M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)2 Hattori M....Yaspo M.L. (2000)
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External Searches for PLAC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PLAC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing PLAC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PLAC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PLAC4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for PLAC4 gene:
Search GeneIP for patents involving PLAC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PLAC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PLAC4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PLAC4 | | OriGene 3'-UTR Clone for PLAC4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PLAC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PLAC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PLAC4 | | OriGene Custom Protein Services for PLAC4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLAC4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PLAC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLAC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLAC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLAC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLAC4 |
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| | | | Search Tocris compounds for PLAC4 |
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 | | | PLAC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAC4 |
|  |  |  | | | | ThermoFisher Antibodies for PLAC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLAC4 |
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