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PLAC4 Gene

protein-coding   GIFtS: 36
GCID: GC21M042547

Placenta-Specific 4

(Previous name: chromosome 21 open reading frame 115)
(Previous symbol: C21orf115)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Placenta-Specific 41 2
C21orf1151 2 3
Chromosome 21 Open Reading Frame 1151
PRED782
Placenta-Specific Protein 42
D21S418E3

External Ids:    HGNC: 146161   Entrez Gene: 1915852   Ensembl: ENSG000002257457   OMIM: 6137705   UniProtKB: Q8WY503   
ORGUL members:         

Export aliases for PLAC4 gene to outside databases

Previous GC identifers: GC21U990111 GC21M041469 GC21M041470


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLAC4 Gene:
PLAC4 (placenta-specific 4) is a protein-coding gene. Diseases associated with PLAC4 include choriocarcinoma, and hypoxia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLAC4 gene promoter:
         C/EBPbeta   NCX/Ncx   Lmo2   Nkx2-5   GATA-1   Evi-1   C/EBPalpha   HSF2   FOXO4   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLAC4 promoter sequence
   Search Chromatin IP Primers for PLAC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLAC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.2

PLAC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLAC4 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M042547:  view genomic region     (about GC identifiers)

Start:
42,547,158 bp from pter      End:
42,558,715 bp from pter
Size:
11,558 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PLAC4_HUMAN, Q8WY50 (See protein sequence)
Recommended Name: Placenta-specific protein 4  
Size: 150 amino acids; 16680 Da

Explore the universe of human proteins at neXtProt for PLAC4: NX_Q8WY50

REFSEQ proteins: NP_878252.2  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8WY50


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for PLAC4:
 Lamellipodia cells 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLAC4
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hsa-miR-4324 hsa-miR-3607-3p hsa-miR-4251 hsa-miR-3662 hsa-miR-580
SwitchGear 3'UTR luciferase reporter plasmidPLAC4 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLAC4
Interactions:

    Search GeneGlobe Interaction Network for PLAC4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for PLAC4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for PLAC4 gene: 
NM_182832.2  

Unigene Cluster for PLAC4:

Placenta-specific 4
Hs.472492  [show with all ESTs]
Unigene Representative Sequence: NM_182832
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000430327(antisense) ENST00000440221(antisense) ENST00000414699(antisense) ENST00000536486(antisense)
miRNA
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hsa-miR-4324 hsa-miR-3607-3p hsa-miR-4251 hsa-miR-3662 hsa-miR-580
SwitchGear 3'UTR luciferase reporter plasmidPLAC4 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat PLAC4

Additional mRNA sequence: 

AF269287.1 AK027868.1 BC093685.1 BC101615.1 BC101617.1 L13197.1 

14 DOTS entries:

DT.95074502  DT.95265783  DT.453893  DT.121129190  DT.100824980  DT.95265781  DT.100824988  DT.121129260 
DT.121129072  DT.95151295  DT.95265780  DT.121129064  DT.121424212  DT.92414622 

Selected AceView cDNA sequences (see all 363):

AU136651 BQ023984 BI056216 AI199819 AU138398 CR607889 AF269287 BX378058 
AU140658 BX356877 AU140503 AU140399 AA368159 AI188452 BQ022365 BQ022372 
CF527924 CB989724 BF993870 AU140374 AU140530 BQ026465 BQ022368 BU752109 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PLAC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
PLAC4 Expression
About this image

PLAC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.472492

UniProtKB/Swiss-Prot: PLAC4_HUMAN, Q8WY50
Tissue specificity: Expressed in placental syncytiotrophoblast and choriocarcinoma cells

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLAC4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for PLAC4 (if available)
TreeFam Gene Tree for PLAC4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PLAC4 gene
1 SIMAP similar gene for PLAC4 using alignment to 2 protein entries:     PLAC4_HUMAN (see all proteins):
NCR3LG1

PLAC4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 1 variation for PLAC4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv7347OTHER Inversion18451855

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing PLAC4
DNA2.0 Custom Variant and Variant Library Synthesis for PLAC4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 613770    OMIM disorders: --

2 diseases for PLAC4:    
About MalaCards
choriocarcinoma    hypoxia


PLAC4 for disorders           About GeneDecksing

Genetic Association Database (GAD): PLAC4
Human Genome Epidemiology (HuGE) Navigator: PLAC4 (3 documents)

Export disorders for PLAC4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PLAC4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with PLAC4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  2. D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells. (PubMed id 8406465)1, 2 Kido S.... Strauss J.F. III (Genomics 1993)
  3. Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21. (PubMed id 19892844)1, 9 Tsui N.B....Lo Y.M. (Clin. Chem. 2010)
  4. Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. (PubMed id 23903356)1 Hayes M.G....Lowe W.L. (Diabetes 2013)
  5. PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia. (PubMed id 23312075)1 Tuohey L....Kaitu'u-Lino T.J. (Placenta 2013)
  6. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  8. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. The DNA sequence of human chromosome 21. (PubMed id 10830953)2 Hattori M.... Yaspo M.-L. (Nature 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 191585 HGNC: 14616 AceView: PLAC4 Ensembl:ENSG00000225745 euGenes: HUgn191585
ECgene: PLAC4 H-InvDB: PLAC4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PLAC4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PLAC4 gene:
Search GeneIP for patents involving PLAC4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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