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PLAC1 Gene

protein-coding   GIFtS: 49
GCID: GC0XM133699

Placenta-Specific 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Placenta-Specific 11 2
Cancer/Testis Antigen 921 2
CT922
OOSP2L2
Placenta-Specific Protein 12

External Ids:    HGNC: 90441   Entrez Gene: 107612   Ensembl: ENSG000001709657   OMIM: 3002965   UniProtKB: Q9HBJ03   
ORGUL members:         

Export aliases for PLAC1 gene to outside databases

Previous GC identifers: GC0XM128345 GC0XM130545 GC0XM131644 GC0XM132405 GC0XM133425 GC0XM133527 GC0XM123098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLAC1 Gene:
PLAC1 (placenta-specific 1) is a protein-coding gene. An important paralog of this gene is OOSP2.

UniProtKB/Swiss-Prot: PLAC1_HUMAN, Q9HBJ0
Function: May play a role in placental development

Gene Wiki entry for PLAC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLAC1 gene promoter:
         AML1a   Tal-1   STAT5A   Ik-3   Evi-1   E47   PPAR-gamma1   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLAC1 promoter sequence
   Search Chromatin IP Primers for PLAC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLAC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

PLAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLAC1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM133699:  view genomic region     (about GC identifiers)

Start:
133,699,868 bp from pter      End:
133,898,352 bp from pter
Size:
198,485 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLAC1_HUMAN, Q9HBJ0 (See protein sequence)
Recommended Name: Placenta-specific protein 1 precursor  
Size: 212 amino acids; 23616 Da

Explore the universe of human proteins at neXtProt for PLAC1: NX_Q9HBJ0

Explore proteomics data for PLAC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys108
  • Modification sites at PhosphoSitePlus

  • See PLAC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068568.1  
    ENSEMBL proteins: 
     ENSP00000352173  

    PLAC1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001507 ZP_dom

    Graphical View of Domain Structure for InterPro Entry Q9HBJ0

    ProtoNet protein and cluster: Q9HBJ0

    UniProtKB/Swiss-Prot: PLAC1_HUMAN, Q9HBJ0
    Similarity: Belongs to the PLAC1 family


    Find genes that share domains with PLAC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLAC1_HUMAN, Q9HBJ0
    Function: May play a role in placental development
    Induction: Up-regulated during trophoblast differentiation and by FGF7 in trophoblast cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with PLAC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PLAC1:
     Decreased Wnt reporter activit 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Plac1):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with PLAC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Plac1tm1(KOMP)Vlcg for PLAC1

       genOway: Develop your customized and physiologically relevant rodent model for PLAC1

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate PLAC1:
    hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidPLAC1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLAC1_HUMAN, Q9HBJ0: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with PLAC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLAC1
    Interactions:

        GeneGlobe Interaction Network for PLAC1

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001890placenta development IEP10995572
    GO:0090214spongiotrophoblast layer developmental growth IEA--

    Find genes that share ontologies with PLAC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLAC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLAC1 gene: 
    NM_021796.3  

    Unigene Cluster for PLAC1:

    Placenta-specific 1
    Hs.496811  [show with all ESTs]
    Unigene Representative Sequence: BC022335
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359237(uc004exo.1 uc004exp.1) ENST00000476971 ENST00000473897
    ENST00000466797
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate PLAC1:
    hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidPLAC1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PLAC1
      QuantiFast Probe-based Assays in human, mouse, rat PLAC1

    Additional mRNA sequence: 

    AF234654.1 AK075086.1 BC022335.1 BC066327.1 

    5 DOTS entries:

    DT.455217  DT.92424674  DT.92424677  DT.121298777  DT.95367069 

    Selected AceView cDNA sequences (see all 78):

    BX386304 CR603619 BF055955 BC022335 AK075086 CR618096 BX359837 AI220650 
    BG184286 CR604394 AW955886 BX356612 CF593309 AA677152 AI078387 AF234654 
    BG202365 BX110037 BX356611 BC066327 CB996101 CF528137 BG013658 NM_021796 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PLAC1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:        -               


    ECgene alternative splicing isoforms for PLAC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLAC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAACAAA
    PLAC1 Expression
    About this image


    PLAC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Endothelial Cells Blood Brain Barrier
             Lateral Ventricle
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    PLAC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLAC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496811

    UniProtKB/Swiss-Prot: PLAC1_HUMAN, Q9HBJ0
    Tissue specificity: Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout
    gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and
    rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for PLAC1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Plac11 , 5 placental specific protein 11, 5 71.35(n)1
    60.23(a)1
      X (29.31 cM)5
    560961  NM_019538.41  NP_062411.11 
     530699955 


    ENSEMBL Gene Tree for PLAC1 (if available)
    TreeFam Gene Tree for PLAC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLAC1 gene
    OOSP22  

    Find genes that share paralogs with PLAC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLAC1 (see all 1189)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753694051,2
    C--123120856(+) TATTT-/T/    
       TATTT
    ATTTA
    1 -- int10--------
    rs2009624841,2
    --133699375(+) CCTCC-/ACTTTC 1 -- ds50010--------
    rs1397193251,2
    --133699526(+) AATTTA/GCTGTC 1 -- ds50010--------
    rs170006431,2
    C,F,H--133699549(+) AGTGAC/TGTGAG 1 -- ds500113--NA NS EA WA 1232
    rs1847275841,2
    --133699711(+) CAGAGA/GGTCAA 1 -- ds50010--------
    rs1461647161,2
    --133699712(+) AGAGGA/GTCAAT 1 -- ds50010--------
    rs1487963981,2
    --133699721(+) ATTGCA/GGAAGG 1 -- ds50010--------
    rs19821,2
    C,F,O,A,H--133699960(+) AGGTTG/TCTCTT 1 -- ut31 trp329Minor allele frequency- N:0.00MN NS EA NA WA CSA 2802
    rs2013919081,2
    C--133700088(+) CCCAAC/TCATAT 2 I V mis10--------
    rs1509334551,2
    C,F--133700398(+) GATGGC/TGTGCC 2 T syn11Minor allele frequency- T:0.01NA 4552

    HapMap Linkage Disequilibrium report for PLAC1 (133699868 - 133898352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PLAC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7102CNV Insertion18451855
    nsv525660CNV Gain19592680
    nsv517076CNV Gain19592680
    nsv521365CNV Gain19592680
    nsv521470CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLAC1
    DNA2.0 Custom Variant and Variant Library Synthesis for PLAC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300296    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PLAC1:
    pre-eclampsia

    Find genes that share disorders with PLAC1           About GenesLikeMe

    1 Novoseek inferred disease relationship for PLAC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preeclampsia 49.5 3 16594548 (3)


    Export disorders for PLAC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLAC1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with PLAC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PLAC1, an Xq26 gene with placenta-specific expression. (PubMed id 10995572)1, 2, 3, 9 Cocchia M.... Schlessinger D. (Genomics 2000)
    2. PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis. (PubMed id 15803460)1, 2, 9 Massabbal E....Fant M. (Mol. Reprod. Dev. 2005)
    3. PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. (PubMed id 12412044)1, 2, 9 Fant M....Schlessinger D. (Mol. Reprod. Dev. 2002)
    4. Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery. (PubMed id 15608456)1, 2, 9 Concu M.... Carinci P. (Fetal Diagn. Ther. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The PLAC1 protein localizes to membranous compartments in the apical region of the syncytiotrophoblast. (PubMed id 17186554)1, 9 Fant M....Bick R. (Mol. Reprod. Dev. 2007)
    8. Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2. (PubMed id 19652226)1, 9 Koslowski M....Sahin U. (J. Biol. Chem. 2009)
    9. PLAC1 mRNA levels in maternal blood at induction of labor correlate negatively with induction-delivery interval. (PubMed id 16860456)1, 9 Rizzo N....Farina A. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2007)
    10. Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia. (PubMed id 16594548)1, 9 Fujito N....Kudo Y. (Hiroshima J. Med. Sci. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10761 HGNC: 9044 AceView: PLAC1 Ensembl:ENSG00000170965 euGenes: HUgn10761
    ECgene: PLAC1 H-InvDB: PLAC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLAC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLAC1 gene:
    Search GeneIP for patents involving PLAC1

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     OriGene Antibodies for PLAC1   OriGene RNAi products in human, mouse, rat for PLAC1  
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     Block miRNA regulation of human, mouse, rat PLAC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PLAC1
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     Browse ESI BIO Cell Lines and PureStem Progenitors for PLAC1
     Gene Synthesis
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     Search Addgene for plasmids for PLAC1
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