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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLA2R1 Gene

protein-coding   GIFtS: 58
GCID: GC02M160788

Phospholipase A2 Receptor 1, 180kDa

(Previous names: phospholipase A2 receptor 1, 180kD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase A2 Receptor 1, 180kDa1 2     M-Type Receptor2 3
PLA2R2 3 5     Phospholipase A2 Receptor 1, 180kD1
180 KDa Secretory Phospholipase A2 Receptor2 3     PLA2G1R2
CLEC13C2 3     PLA2IR2
PLA2-R2 3     Secretory Phospholipase A2 Receptor2
C-Type Lectin Domain Family 13 Member C2 3     

External Ids:    HGNC: 90421   Entrez Gene: 229252   Ensembl: ENSG000001532467   OMIM: 6049395   UniProtKB: Q130183   

Export aliases for PLA2R1 gene to outside databases

Previous GC identifers: GC02M158728 GC02M159326 GC02M160752 GC02M160999 GC02M160622 GC02M160505 GC02M152681


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLA2R1 Gene:
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form
and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby
inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic
membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been
identified.(provided by RefSeq, Sep 2010)

GeneCards Summary for PLA2R1 Gene: 
PLA2R1 (phospholipase A2 receptor 1, 180kDa) is a protein-coding gene. Diseases associated with PLA2R1 include membranous glomerulonephritis, and glomerulonephritis. GO annotations related to this gene include receptor activity and phospholipase binding. An important paralog of this gene is LY75.

UniProtKB/Swiss-Prot: PLA2R_HUMAN, Q13018
Function: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B
but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains
unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2
functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the
cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell
proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived
mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and
cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also
has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the
clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory
phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the
biological functions of sPLA2-IB/PLA2G1B

Gene Wiki entry for PLA2R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLA2R1 gene promoter:
         LHX3b/Lhx3b   RFX1   Evi-1   MEF-2A   Ik-2   POU2F1   POU2F1a   LHX3a/Lhx3a   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2R1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLA2R1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23-q24   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q23-q24

PLA2R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2R1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M160788:  view genomic region     (about GC identifiers)

Start:
160,788,519 bp from pter      End:
160,919,126 bp from pter
Size:
130,608 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PLA2R_HUMAN, Q13018 (See protein sequence)
Recommended Name: Secretory phospholipase A2 receptor precursor  
Size: 1463 amino acids; 168600 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Subcellular location: Soluble secretory phospholipase A2 receptor: Secreted (By similarity)
Subcellular location: Isoform 2: Secreted (Potential)
Secondary accessions: B2RTU9 D3DPB1 Q13019 Q15095 Q53R45 Q53RR7
Alternative splicing: 2 isoforms:  Q13018-1   Q13018-2   

Explore the universe of human proteins at neXtProt for PLA2R1: NX_Q13018

Explore proteomics data for PLA2R1 at MOPED 

Post-translational modifications:

  • UniProtKB: The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all
    extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form
    is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case
    of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13018

  • PLA2R1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLA2R1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001007268.1  NP_001182570.1  NP_031392.3  

    ENSEMBL proteins: 
     ENSP00000283243   ENSP00000376524  

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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS7721806
    GO:0005886plasma membrane IDA12225974
    GO:0005887integral to plasma membrane NAS7721806
    GO:0009986cell surface IDA15611272
    GO:0016021integral to membrane IEA--

    PLA2R1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLEC: C-type lectin domain containing

    5/7 InterPro protein domains (see all 7):
     IPR000772 Ricin_B_lectin
     IPR016187 C-type_lectin_fold
     IPR013806 Kringle-like
     IPR018378 C-type_lectin_CS
     IPR000562 FN_type2_col-bd

    Graphical View of Domain Structure for InterPro Entry Q13018

    ProtoNet protein and cluster: Q13018

    3 Blocks protein domains:
    IPB000165 Glycoside hydrolase
    IPB000562 Type II fibronectin collagen-binding domain
    IPB000772 Ricin B lectin domain


    UniProtKB/Swiss-Prot: PLA2R_HUMAN, Q13018
    Domain: C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B
    Domain: The endocytosis signal probably mediates endocytosis via clathrin-coated pits (By similarity)
    Similarity: Contains 8 C-type lectin domains
    Similarity: Contains 1 fibronectin type-II domain
    Similarity: Contains 1 ricin B-type lectin domain


    PLA2R1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLA2R_HUMAN, Q13018
    Function: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B
    but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains
    unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2
    functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the
    cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell
    proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived
    mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and
    cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also
    has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the
    clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory
    phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the
    biological functions of sPLA2-IB/PLA2G1B

         Genatlas biochemistry entry for PLA2R1:
    phospholipase A2 receptor 1(180kDa),soluble and membrane bound isoforms,expressed in kidney

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA7721806
    GO:0030246carbohydrate binding IEA--
    GO:0043274phospholipase binding IPI7721806
         
    PLA2R1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PLA2R1:
     Decreased G3BP1 protein expres  Decreased viability with carbo  Decreased viability with pacli 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pla2r1):
     immune system 

    PLA2R1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pla2r1tm1Itoh for PLA2R1

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLA2R1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Tuberculosis
    Tuberculosis
    2Phagosome
    Phagosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for PLA2R1):
        Phagosome
    Tuberculosis


    PLA2R1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLA2R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for PLA2R1 (Q130183 ENSP000002832434) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLA2G2AP145553, ENSP000003642524I2D: score=1 STRING: ENSP00000364252
    PLA2G10O154963, ENSP000003938474I2D: score=1 STRING: ENSP00000393847
    IL10ENSP000004122374STRING: ENSP00000412237
    TGFB1ENSP000002219304STRING: ENSP00000221930
    TGFB2ENSP000003558964STRING: ENSP00000355896
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production IMP15611272
    GO:0006898receptor-mediated endocytosis IEA--
    GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator IMP19197340
    GO:0072593reactive oxygen species metabolic process IDA19197340
    GO:0090238positive regulation of arachidonic acid secretion ISS--

    PLA2R1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PLA2R1 (PLA2R)

    Search CenterWatch for drugs/clinical trials and news about PLA2R1 / PLA2R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLA2R1 gene (3 alternative transcripts): 
    NM_001007267.2  NM_001195641.1  NM_007366.4  

    Unigene Cluster for PLA2R1:

    Phospholipase A2 receptor 1, 180kDa
    Hs.410477  [show with all ESTs]
    Unigene Representative Sequence: NM_007366
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460710 ENST00000283243(uc002ube.2 uc010zcp.2) ENST00000392771(uc002ubf.3)

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    Additional mRNA sequence: 

    BC065212.1 BC140823.1 BC144631.1 BX640976.1 D30780.1 U17033.1 U17034.1 

    9 DOTS entries:

    DT.100749997  DT.209983  DT.91822923  DT.70101419  DT.75113516  DT.120985526  DT.75100892  DT.120985540 
    DT.92011107 

    24/85 AceView cDNA sequences (see all 85):

    D30780 AL598405 AL042477 BQ639465 BC065212 AL598421 BQ025507 BG698151 
    BF725498 BX507907 CB160329 W04525 BX485732 BX485402 AW614826 W39728 
    BX640976 BV206713 W31693 W44657 BP351340 AL602995 BG743384 BX092141 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2R1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                                                -     -                     
    SP2:                                                                                                                                -     -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30
    SP1:                          -         
    SP2:                                    
    SP3:                                    
    SP4:                                    


    ECgene alternative splicing isoforms for PLA2R1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLA2R1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PLA2R1 Expression
    About this image


    See PLA2R1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLA2R1

    SOURCE GeneReport for Unigene cluster: Hs.410477

    UniProtKB/Swiss-Prot: PLA2R_HUMAN, Q13018
    Tissue specificity: Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in
    pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PLA2R1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2r11 , 5 phospholipase A2 receptor 11, 5 79.95(n)1
    74.46(a)1
      2 (34.65 cM)5
    187791  NM_008867.21  NP_032893.11 
     604175435 
    chicken
    (Gallus gallus)
    Aves PLA2R11 phospholipase A2 receptor 1, 180kDa 66.06(n)
    56.94(a)
      404304  NM_206983.1  NP_996866.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLA2R16
    phospholipase A2 receptor 1, 180kDa
    52(a)
    1 ↔ 1
    GL343371.1(731852-812076)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005380381 secretory phospholipase A2 receptor-like 53.11(n)
    45.82(a)
      100538038  XM_003199428.1  XP_003199476.1 


    ENSEMBL Gene Tree for PLA2R1 (if available)
    TreeFam Gene Tree for PLA2R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLA2R1 gene
    LY752  MRC12  LY75-CD3022  MRC22  
    4 SIMAP similar genes for PLA2R1 using alignment to 3 protein entries:     PLA2R_HUMAN (see all proteins):
    MRC2    DKFZp686H17246    LY75    REG1A

    PLA2R1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2632 SNPs in PLA2R1 are shown (see all 2632)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710003241,2
    C,F--152753567(+) TCTGT-/CTCTCTCTCTCTCTCTC/CTCTC
    TCTCTCTCTCTCTGT
    /GTGTGTGTG
    GTGTG
    6 -- int1 cds12NA 4
    rs1810781491,2
    --160796797(+) TTTTAC/TGCATA 2 -- ds50010--------
    rs1851191361,2
    --160796911(+) TAGAAC/TAGCAC 2 -- ds50010--------
    rs1420319691,2
    --160796918(+) GCACTA/TTTTTG 2 -- ds50010--------
    rs1895396191,2
    --160797314(+) AGATAA/TCTAGA 2 -- ut310--------
    rs610946891,2
    C--160797597(+) GCCACA/CTTTTA 2 -- ut314Minor allele frequency- C:0.20WA NA EA 360
    rs770947601,2
    C,F--160797693(+) GATGTT/CAGACC 2 -- ut312Minor allele frequency- C:0.25CSA WA 120
    rs1459833361,2
    C--160797848(+) TTTCCC/TCTCAT 2 -- ut310--------
    rs2010623241,2
    --160797866(+) ATTAA-/TTTTTT 2 -- ut310--------
    rs1388613201,2
    C--160797993(+) TATTCA/GCATTG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PLA2R1 (160788519 - 160919126 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for PLA2R1 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721035CNV Deletion23290073
    esv1565630CNV Deletion17803354
    dgv742e199CNV Deletion23128226
    esv2291297CNV Deletion18987734
    esv5014CNV Deletion18987735
    esv1000137CNV Deletion20482838
    esv2596999CNV Deletion19546169
    esv2468197CNV Deletion19546169
    nsv875345CNV Loss21882294
    nsv213665CNV Loss16902084


    Human Gene Mutation Database (HGMD): PLA2R1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PLA2R1
    DNA2.0 Custom Variant and Variant Library Synthesis for PLA2R1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604939    OMIM disorders: --

    5 diseases for PLA2R1:    About MalaCards
    membranous glomerulonephritis    glomerulonephritis    retinitis    tuberculosis
    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for PLA2R1:
    Membranous glomerulonephritis

    PLA2R1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLA2R1
    Human Genome Epidemiology (HuGE) Navigator: PLA2R1 (4 documents)

    Export disorders for PLA2R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLA2R1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with PLA2R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. (PubMed id 7721806)1, 2, 3 Ancian P.... Lazdunski M. (1995)
    2. Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals. (PubMed id 7925459)1, 2, 3 Higashino K.... Arita H. (1994)
    3. Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic memb ranous nephropathy. (PubMed id 21323541)1, 4 Stanescu H.C....Kleta R. (2011)
    4. Association of phospholipase A2 receptor 1 polymorphi sms with idiopathic membranous nephropathy in Chinese patients in Taiwan. (PubMed id 20937089)1, 4 Liu Y.H....Tsai F.J. (2010)
    5. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    6. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. (PubMed id 15611272)1, 2 Granata F.... Triggiani M. (2005)
    7. Phospholipase A2 receptor (PLA2R1) sequence variants i n idiopathic membranous nephropathy. (PubMed id 23431073)1 Coenen M.J....Ronco P. (2013)
    8. Development of a high resolution melting method for ge notyping of risk HLA-DQA1 and PLA2R1 alleles and ethnic distribution of these ri sk alleles. (PubMed id 23194743)1 Cui G....Wang D.W. (2013)
    9. Enhanced expression of the M-type phospholipase A2 rec eptor in glomeruli correlates with serum receptor antibodies in primary membrano us nephropathy. (PubMed id 22673885)1 Hoxha E....Stahl R.A. (2012)
    10. Pathogenesis of membranous nephropathy: recent advance s and future challenges. (PubMed id 22371247)1 Ronco P. and Debiec H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22925 HGNC: 9042 AceView: PLA2R1 Ensembl:ENSG00000153246 euGenes: HUgn22925
    ECgene: PLA2R1 Kegg: 22925 H-InvDB: PLA2R1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLA2R1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_253

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLA2R1 gene:
    Search GeneIP for patents involving PLA2R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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