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PLA2R1 Gene

protein-coding   GIFtS: 57
GCID: GC02M160788

Phospholipase A2 Receptor 1, 180kDa

(Previous names: phospholipase A2 receptor 1, 180kD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase A2 Receptor 1, 180kDa1 2     M-Type Receptor2 3
PLA2R2 3 5     Phospholipase A2 Receptor 1, 180kD1
180 KDa Secretory Phospholipase A2 Receptor2 3     PLA2G1R2
CLEC13C2 3     PLA2IR2
PLA2-R2 3     Secretory Phospholipase A2 Receptor2
C-Type Lectin Domain Family 13 Member C2 3     

External Ids:    HGNC: 90421   Entrez Gene: 229252   Ensembl: ENSG000001532467   OMIM: 6049395   UniProtKB: Q130183   

Export aliases for PLA2R1 gene to outside databases

Previous GC identifers: GC02M158728 GC02M159326 GC02M160752 GC02M160999 GC02M160622 GC02M160505 GC02M152681


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLA2R1 Gene:
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form
and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby
inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic
membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been
identified.(provided by RefSeq, Sep 2010)

GeneCards Summary for PLA2R1 Gene:
PLA2R1 (phospholipase A2 receptor 1, 180kDa) is a protein-coding gene. GO annotations related to this gene include receptor activity and phospholipase binding. An important paralog of this gene is LY75.

UniProtKB/Swiss-Prot: PLA2R_HUMAN, Q13018
Function: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B
but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains
unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2
functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the
cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell
proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived
mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and
cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also
has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the
clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory
phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the
biological functions of sPLA2-IB/PLA2G1B

Gene Wiki entry for PLA2R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLA2R1 gene promoter:
         LHX3b/Lhx3b   RFX1   Evi-1   MEF-2A   Ik-2   POU2F1   POU2F1a   LHX3a/Lhx3a   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2R1 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLA2R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23-q24   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q23-q24

PLA2R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2R1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M160788:  view genomic region     (about GC identifiers)

Start:
160,788,519 bp from pter      End:
160,919,126 bp from pter
Size:
130,608 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLA2R_HUMAN, Q13018 (See protein sequence)
Recommended Name: Secretory phospholipase A2 receptor precursor  
Size: 1463 amino acids; 168600 Da
Secondary accessions: B2RTU9 D3DPB1 Q13019 Q15095 Q53R45 Q53RR7
Alternative splicing: 2 isoforms:  Q13018-1   Q13018-2   

Explore the universe of human proteins at neXtProt for PLA2R1: NX_Q13018

Explore proteomics data for PLA2R1 at MOPED

Post-translational modifications: 

  • The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all
    extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form
    is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case
    of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity)1
  • Glycosylation2 at Asn93, Asn454
  • Modification sites at PhosphoSitePlus

  • See PLA2R1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001007268.1  NP_001182570.1  NP_031392.3  

    ENSEMBL proteins: 
     ENSP00000283243   ENSP00000376524  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    Selected InterPro protein domains (see all 6):
     IPR000772 Ricin_B_lectin
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR000562 FN_type2_col-bd
     IPR016186 C-type_lectin-like

    Graphical View of Domain Structure for InterPro Entry Q13018

    ProtoNet protein and cluster: Q13018

    3 Blocks protein domains:
    IPB000165 Glycoside hydrolase
    IPB000562 Type II fibronectin collagen-binding domain
    IPB000772 Ricin B lectin domain


    UniProtKB/Swiss-Prot: PLA2R_HUMAN, Q13018
    Domain: C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B
    Domain: The endocytosis signal probably mediates endocytosis via clathrin-coated pits (By similarity)
    Similarity: Contains 8 C-type lectin domains
    Similarity: Contains 1 fibronectin type-II domain
    Similarity: Contains 1 ricin B-type lectin domain


    Find genes that share domains with PLA2R1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLA2R_HUMAN, Q13018
    Function: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B
    but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains
    unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2
    functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the
    cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell
    proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived
    mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and
    cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also
    has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the
    clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory
    phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the
    biological functions of sPLA2-IB/PLA2G1B

         Genatlas biochemistry entry for PLA2R1:
    phospholipase A2 receptor 1(180kDa),soluble and membrane bound isoforms,expressed in kidney

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA7721806
    GO:0030246carbohydrate binding IEA--
    GO:0043274phospholipase binding IPI7721806
         
    Find genes that share ontologies with PLA2R1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PLA2R1:
     Decreased G3BP1 protein expres  Decreased viability with carbo  Decreased viability with pacli 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pla2r1):
     immune system 

    Find genes that share phenotypes with PLA2R1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pla2r1tm1Itoh for PLA2R1

       genOway: Develop your customized and physiologically relevant rodent model for PLA2R1

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    hsa-miR-218 hsa-miR-29b-1* hsa-miR-4275 hsa-miR-511 hsa-miR-4314 hsa-miR-633 hsa-miR-3658 hsa-miR-29a*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLA2R_HUMAN, Q13018: Cell membrane; Single-pass type I membrane protein (By similarity)
    PLA2R_HUMAN, Q13018: Soluble secretory phospholipase A2 receptor: Secreted (By similarity)
    PLA2R_HUMAN, Q13018: Isoform 2: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    cytosol1
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS7721806
    GO:0005886plasma membrane IDA12225974
    GO:0005887integral component of plasma membrane NAS7721806
    GO:0009986cell surface IDA15611272
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PLA2R1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLA2R1 About    
    See pathways by source

    SuperPathContained pathways About
    1Tuberculosis
    Tuberculosis
    2Phagosome
    Phagosome


    Find genes that share SuperPaths with PLA2R1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for PLA2R1):
        Phagosome
    Tuberculosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLA2R1
    Interactions:

        Search GeneGlobe Interaction Network for PLA2R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for PLA2R1 (Q130183 ENSP000002832434) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLA2G2AP145553, ENSP000003642524I2D: score=1 STRING: ENSP00000364252
    PLA2G10O154963, ENSP000003938474I2D: score=1 STRING: ENSP00000393847
    IL10ENSP000004122374STRING: ENSP00000412237
    TGFB1ENSP000002219304STRING: ENSP00000221930
    TGFB2ENSP000003558964STRING: ENSP00000355896
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production IMP15611272
    GO:0006898receptor-mediated endocytosis IEA--
    GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator IMP19197340
    GO:0072593reactive oxygen species metabolic process IDA19197340
    GO:0090238positive regulation of arachidonic acid secretion ISS--

    Find genes that share ontologies with PLA2R1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLA2R1 (PLA2R)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLA2R1 gene (3 alternative transcripts): 
    NM_001007267.2  NM_001195641.1  NM_007366.4  

    Unigene Cluster for PLA2R1:

    Phospholipase A2 receptor 1, 180kDa
    Hs.410477  [show with all ESTs]
    Unigene Representative Sequence: NM_007366
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460710 ENST00000283243(uc002ube.2 uc010zcp.2) ENST00000392771(uc002ubf.3)

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    hsa-miR-218 hsa-miR-29b-1* hsa-miR-4275 hsa-miR-511 hsa-miR-4314 hsa-miR-633 hsa-miR-3658 hsa-miR-29a*
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    Additional mRNA sequence: 

    BC065212.1 BC140823.1 BC144631.1 BX640976.1 D30780.1 U17033.1 U17034.1 

    9 DOTS entries:

    DT.100749997  DT.209983  DT.91822923  DT.70101419  DT.75113516  DT.120985526  DT.75100892  DT.120985540 
    DT.92011107 

    Selected AceView cDNA sequences (see all 85):

    CB160329 BX507907 BF725498 BG698151 BQ025507 AL598421 BC065212 BQ639465 
    AL042477 AL598405 D30780 AI672072 CA393299 BF197556 BG742567 H27613 
    NM_007366 BG674687 BX111897 BX485451 CK003270 R91516 U17034 AI820785 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2R1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                                                -     -                     
    SP2:                                                                                                                                -     -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30
    SP1:                          -         
    SP2:                                    
    SP3:                                    
    SP4:                                    


    ECgene alternative splicing isoforms for PLA2R1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLA2R1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PLA2R1 Expression
    About this image


    PLA2R1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
    PLA2R1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLA2R1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410477

    UniProtKB/Swiss-Prot: PLA2R_HUMAN, Q13018
    Tissue specificity: Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in
    pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLA2R1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2r11 , 5 phospholipase A2 receptor 11, 5 79.99(n)1
    74.64(a)1
      2 (34.65 cM)5
    187791  NM_008867.21  NP_032893.11 
     604175435 
    chicken
    (Gallus gallus)
    Aves PLA2R11 phospholipase A2 receptor 1, 180kDa 66.11(n)
    56.95(a)
      404304  NM_206983.1  NP_996866.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLA2R16
    phospholipase A2 receptor 1, 180kDa
    52(a)
    1 ↔ 1
    GL343371.1(731852-812076)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pla2r11 phospholipase A2 receptor 1, 180kDa 56.99(n)
    46.09(a)
      100488773  XM_002933277.2  XP_002933323.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005380381 secretory phospholipase A2 receptor-like 52.07(n)
    42.56(a)
      100538038  XM_005155726.1  XP_005155783.1 
    worm
    (Caenorhabditis elegans)
    Secernentea clec-506
    clec-486
    (see all 7)
    Protein CLEC-48 (clec-48) mRNA, complete cds
    (see all 7)
    23(a)
    23(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    V(19752401-19755363) WBGene00012253
    V(18158027-18159610) WBGene00007565


    ENSEMBL Gene Tree for PLA2R1 (if available)
    TreeFam Gene Tree for PLA2R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLA2R1 gene
    LY752  ENSG000001837482  MRC12  LY75-CD3022  MRC22  
    4 SIMAP similar genes for PLA2R1 using alignment to 3 protein entries:     PLA2R_HUMAN (see all proteins):
    MRC2    DKFZp686H17246    LY75    REG1A

    Find genes that share paralogs with PLA2R1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLA2R1 (see all 2632)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710003241,2
    C,F--152753567(+) TCTGT-/CTCTCTCTCTCTCTCTC/CTCTC
    TCTCTCTCTCTCTGT
    /GTGTGTGTG
    GTGTG
    6 -- int1 cds12NA 4
    rs1810781491,2
    --160796797(+) TTTTAC/TGCATA 2 -- ds50010--------
    rs1851191361,2
    --160796911(+) TAGAAC/TAGCAC 2 -- ds50010--------
    rs1420319691,2
    --160796918(+) GCACTA/TTTTTG 2 -- ds50010--------
    rs1895396191,2
    --160797314(+) AGATAA/TCTAGA 2 -- ut310--------
    rs610946891,2
    C--160797597(+) GCCACA/CTTTTA 2 -- ut314Minor allele frequency- C:0.20WA NA EA 360
    rs770947601,2
    C,F--160797693(+) GATGTT/CAGACC 2 -- ut312Minor allele frequency- C:0.25CSA WA 120
    rs1459833361,2
    C--160797848(+) TTTCCC/TCTCAT 2 -- ut310--------
    rs2010623241,2
    --160797866(+) ATTAA-/TTTTTT 2 -- ut310--------
    rs1388613201,2
    C--160797993(+) TATTCA/GCATTG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PLA2R1 (160788519 - 160919126 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PLA2R1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721035CNV Deletion23290073
    esv1565630CNV Deletion17803354
    dgv742e199CNV Deletion23128226
    esv2291297CNV Deletion18987734
    esv5014CNV Deletion18987735
    esv1000137CNV Deletion20482838
    esv2596999CNV Deletion19546169
    esv2468197CNV Deletion19546169
    nsv875345CNV Loss21882294
    nsv213665CNV Loss16902084

    Human Gene Mutation Database (HGMD): PLA2R1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLA2R1
    DNA2.0 Custom Variant and Variant Library Synthesis for PLA2R1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604939    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PLA2R1:
    Membranous glomerulonephritis

    Find genes that share disorders with PLA2R1           About GenesLikeMe

    Genetic Association Database (GAD): PLA2R1
    Human Genome Epidemiology (HuGE) Navigator: PLA2R1 (4 documents)

    Export disorders for PLA2R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLA2R1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with PLA2R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. (PubMed id 7721806)1, 2, 3 Ancian P.... Lazdunski M. (J. Biol. Chem. 1995)
    2. Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals. (PubMed id 7925459)1, 2, 3 Higashino K.... Arita H. (Eur. J. Biochem. 1994)
    3. Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. (PubMed id 21323541)1, 4 Stanescu H.C....Kleta R. (N. Engl. J. Med. 2011)
    4. Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan. (PubMed id 20937089)1, 4 Liu Y.H....Tsai F.J. (J. Biomed. Sci. 2010)
    5. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    6. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. (PubMed id 15611272)1, 2 Granata F.... Triggiani M. (J. Immunol. 2005)
    7. Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy. (PubMed id 23813219)1 Lv J....Zhang H. (J. Am. Soc. Nephrol. 2013)
    8. Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy. (PubMed id 23431073)1 Coenen M.J....Ronco P. (J. Am. Soc. Nephrol. 2013)
    9. Development of a high resolution melting method for genotyping of risk HLA-DQA1 and PLA2R1 alleles and ethnic distribution of these risk alleles. (PubMed id 23194743)1 Cui G....Wang D.W. (Gene 2013)
    10. Determination of primary versus secondary membranous glomerulopathy utilizing phospholipase A2 receptor staining in renal biopsies. (PubMed id 23196797)1 Larsen C.P....Walker P.D. (Mod. Pathol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22925 HGNC: 9042 AceView: PLA2R1 Ensembl:ENSG00000153246 euGenes: HUgn22925
    ECgene: PLA2R1 Kegg: 22925 H-InvDB: PLA2R1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLA2R1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_253

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLA2R1 gene:
    Search GeneIP for patents involving PLA2R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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