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Aliases for PLA2R1 Gene

Aliases for PLA2R1 Gene

  • Phospholipase A2 Receptor 1, 180kDa 2 3
  • PLA2R 3 4 6
  • 180 KDa Secretory Phospholipase A2 Receptor 3 4
  • C-Type Lectin Domain Family 13 Member C 3 4
  • Phospholipase A2 Receptor 1, 180kD 2 3
  • M-Type Receptor 3 4
  • CLEC13C 3 4
  • PLA2-R 3 4
  • Secretory Phospholipase A2 Receptor 3
  • PLA2G1R 3
  • PLA2IR 3

External Ids for PLA2R1 Gene

Summaries for PLA2R1 Gene

Entrez Gene Summary for PLA2R1 Gene

  • This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

GeneCards Summary for PLA2R1 Gene

PLA2R1 (Phospholipase A2 Receptor 1, 180kDa) is a Protein Coding gene. Among its related pathways are Tuberculosis and Phagosome. GO annotations related to this gene include receptor activity and phospholipase binding. An important paralog of this gene is MRC2.

UniProtKB/Swiss-Prot for PLA2R1 Gene

  • Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Gene Wiki entry for PLA2R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2R1 Gene

Genomics for PLA2R1 Gene

Genomic Location for PLA2R1 Gene

Start:
159,932,006 bp from pter
End:
160,062,615 bp from pter
Size:
130,610 bases
Orientation:
Minus strand

Genomic View for PLA2R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2R1 Gene

Regulatory Elements for PLA2R1 Gene

Proteins for PLA2R1 Gene

  • Protein details for PLA2R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13018-PLA2R_HUMAN
    Recommended name:
    Secretory phospholipase A2 receptor
    Protein Accession:
    Q13018
    Secondary Accessions:
    • B2RTU9
    • D3DPB1
    • Q13019
    • Q15095
    • Q53R45
    • Q53RR7

    Protein attributes for PLA2R1 Gene

    Size:
    1463 amino acids
    Molecular mass:
    168600 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2R1 Gene

Proteomics data for PLA2R1 Gene at MOPED

Post-translational modifications for PLA2R1 Gene

  • The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn93 and Asn454

Other Protein References for PLA2R1 Gene

No data available for DME Specific Peptides for PLA2R1 Gene

Domains for PLA2R1 Gene

Gene Families for PLA2R1 Gene

HGNC:
  • CLEC :C-type lectin domain containing

UniProtKB/Swiss-Prot:

PLA2R_HUMAN
Domain:
  • C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B:
    • Q13018
  • The endocytosis signal probably mediates endocytosis via clathrin-coated pits.:
    • Q13018
  • Contains 8 C-type lectin domains.:
    • Q13018
  • Contains 1 fibronectin type-II domain.:
    • Q13018
  • Contains 1 ricin B-type lectin domain.:
    • Q13018
genes like me logo Genes that share domains with PLA2R1: view

Function for PLA2R1 Gene

Molecular function for PLA2R1 Gene

GENATLAS Biochemistry: phospholipase A2 receptor 1(180kDa),soluble and membrane bound isoforms,expressed in kidney
UniProtKB/Swiss-Prot Function: Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Gene Ontology (GO) - Molecular Function for PLA2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 7721806
GO:0030246 carbohydrate binding IEA --
GO:0043274 phospholipase binding IPI 7721806
genes like me logo Genes that share ontologies with PLA2R1: view
genes like me logo Genes that share phenotypes with PLA2R1: view

Animal Models for PLA2R1 Gene

MGI Knock Outs for PLA2R1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PLA2R1 Gene

Localization for PLA2R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2R1 Gene

Cell membrane; Single-pass type I membrane protein.
Soluble secretory phospholipase A2 receptor: Secreted.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2R1 Gene COMPARTMENTS Subcellular localization image for PLA2R1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLA2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 7721806
GO:0005886 plasma membrane IDA 12225974
GO:0005887 integral component of plasma membrane NAS 7721806
GO:0009986 cell surface IDA 15611272
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLA2R1: view

Pathways for PLA2R1 Gene

SuperPathways for PLA2R1 Gene

Superpath Contained pathways
1 Tuberculosis
2 Phagosome
genes like me logo Genes that share pathways with PLA2R1: view

Pathways by source for PLA2R1 Gene

2 KEGG pathways for PLA2R1 Gene

Interacting Proteins for PLA2R1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283243%0d%0a9606.ENSP00000393847%0d%0a9606.ENSP00000364252%0d%0a
Selected Interacting proteins: ENSP00000283243 Q13018-PLA2R_HUMAN for PLA2R1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PLA2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IMP 15611272
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis IDA 7721806
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IMP 19197340
GO:0072593 reactive oxygen species metabolic process IDA 19197340
genes like me logo Genes that share ontologies with PLA2R1: view

Transcripts for PLA2R1 Gene

Unigene Clusters for PLA2R1 Gene

Phospholipase A2 receptor 1, 180kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2R1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - -
SP2: - -
SP3:
SP4:

ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for PLA2R1 Gene

GeneLoc Exon Structure for
PLA2R1
ECgene alternative splicing isoforms for
PLA2R1

Expression for PLA2R1 Gene

mRNA expression in normal human tissues for PLA2R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2R1 Gene

This gene is overexpressed in Thyroid (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLA2R1 Gene

SOURCE GeneReport for Unigene cluster for PLA2R1 Gene Hs.410477

mRNA Expression by UniProt/SwissProt for PLA2R1 Gene

Q13018-PLA2R_HUMAN
Tissue specificity: Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level.
genes like me logo Genes that share expressions with PLA2R1: view

Orthologs for PLA2R1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2R1 36
  • 99.52 (n)
  • 99.31 (a)
PLA2R1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLA2R1 36
  • 87.68 (n)
  • 84.32 (a)
PLA2R1 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2R1 36
  • 88.76 (n)
  • 86.04 (a)
PLA2R1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2r1 36
  • 79.99 (n)
  • 74.64 (a)
Pla2r1 16
Pla2r1 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLA2R1 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2R1 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2r1 36
  • 79.07 (n)
  • 73.61 (a)
chicken
(Gallus gallus)
Aves PLA2R1 36
  • 66.11 (n)
  • 56.95 (a)
PLA2R1 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2R1 37
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2r1 36
  • 56.99 (n)
  • 46.09 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100538038 36
  • 52.07 (n)
  • 42.56 (a)
PLA2R1 37
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clec-148 37
  • 19 (a)
ManyToMany
clec-48 37
  • 23 (a)
ManyToMany
clec-49 37
  • 22 (a)
ManyToMany
clec-50 37
  • 23 (a)
ManyToMany
clec-51 37
  • 20 (a)
ManyToMany
clec-52 37
  • 20 (a)
ManyToMany
clec-53 37
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
OneToMany
Species with no ortholog for PLA2R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2R1 Gene

ENSEMBL:
Gene Tree for PLA2R1 (if available)
TreeFam:
Gene Tree for PLA2R1 (if available)

Paralogs for PLA2R1 Gene

Paralogs for PLA2R1 Gene

Selected SIMAP similar genes for PLA2R1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA2R1: view

Variants for PLA2R1 Gene

Sequence variations from dbSNP and Humsavar for PLA2R1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs769369 -- 159,938,745(+) TACCA(A/G)GACAC intron-variant
rs769370 -- 159,938,765(+) TTATA(A/T)ATCCA intron-variant
rs883423 -- 160,023,140(-) atcgg(C/T)catct intron-variant
rs907242 -- 160,024,234(-) CTCAA(A/G)GATGG intron-variant
rs907243 -- 160,023,927(-) GCTCT(A/G)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2R1 Gene

Variant ID Type Subtype PubMed ID
nsv834436 CNV Loss 17160897
nsv875345 CNV Loss 21882294
nsv2997 CNV Loss 18451855
esv2468197 CNV Deletion 19546169
esv2291297 CNV Deletion 18987734
esv2721035 CNV Deletion 23290073
esv5014 CNV Deletion 18987735
nsv213665 CNV Loss 16902084
esv1000137 CNV Deletion 20482838
esv2596999 CNV Deletion 19546169
esv1565630 CNV Deletion 17803354
esv8839 CNV Loss 19470904
dgv742e199 CNV Deletion 23128226

Relevant External Links for PLA2R1 Gene

HapMap Linkage Disequilibrium report
PLA2R1
Human Gene Mutation Database (HGMD)
PLA2R1

Disorders for PLA2R1 Gene

(1) University of Copenhagen DISEASES for PLA2R1 Gene

Relevant External Links for PLA2R1

Genetic Association Database (GAD)
PLA2R1
Human Genome Epidemiology (HuGE) Navigator
PLA2R1
genes like me logo Genes that share disorders with PLA2R1: view

No data available for UniProtKB/Swiss-Prot for PLA2R1 Gene

Publications for PLA2R1 Gene

  1. The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. (PMID: 7721806) Ancian P. … Lazdunski M. (J. Biol. Chem. 1995) 2 3 4
  2. Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals. (PMID: 7925459) Higashino K. … Arita H. (Eur. J. Biochem. 1994) 2 3 4
  3. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. (PMID: 15611272) Granata F. … Triggiani M. (J. Immunol. 2005) 3 4
  4. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I. … Robledo M. (PLoS Genet. 2009) 3 49
  5. Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan. (PMID: 20937089) Liu Y.H. … Tsai F.J. (J. Biomed. Sci. 2010) 3 49

Products for PLA2R1 Gene

Sources for PLA2R1 Gene

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