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Aliases for PLA2R1 Gene

Aliases for PLA2R1 Gene

  • Phospholipase A2 Receptor 1 2 3 5
  • 180 KDa Secretory Phospholipase A2 Receptor 3 4
  • C-Type Lectin Domain Family 13 Member C 3 4
  • Phospholipase A2 Receptor 1, 180kDa 2 3
  • Phospholipase A2 Receptor 1, 180kD 2 3
  • M-Type Receptor 3 4
  • CLEC13C 3 4
  • PLA2-R 3 4
  • PLA2R 3 4
  • Secretory Phospholipase A2 Receptor 3
  • PLA2G1R 3
  • PLA2IR 3

External Ids for PLA2R1 Gene

Previous GeneCards Identifiers for PLA2R1 Gene

  • GC02M158728
  • GC02M159326
  • GC02M160752
  • GC02M160999
  • GC02M160622
  • GC02M160505
  • GC02M152681
  • GC02M160788

Summaries for PLA2R1 Gene

Entrez Gene Summary for PLA2R1 Gene

  • This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

GeneCards Summary for PLA2R1 Gene

PLA2R1 (Phospholipase A2 Receptor 1) is a Protein Coding gene. Diseases associated with PLA2R1 include Membranoproliferative Glomerulonephritis and Membranous Nephropathy. Among its related pathways are Tuberculosis and Acyl chain remodelling of PE. GO annotations related to this gene include receptor activity and phospholipase binding. An important paralog of this gene is LY75.

UniProtKB/Swiss-Prot for PLA2R1 Gene

  • Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Gene Wiki entry for PLA2R1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2R1 Gene

Genomics for PLA2R1 Gene

Regulatory Elements for PLA2R1 Gene

Enhancers for PLA2R1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G160073 1.1 Ensembl ENCODE 21.7 -13.6 -13625 5.7 ELF3 FOXA2 RARA GATA2 FOS HMG20B KLF11 CEBPB KAT8 MBD2 PLA2R1 PIR61464
GH02G160363 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -310.3 -310259 19.5 SIN3A FEZF1 YY1 GLIS2 GATA2 ZNF143 FOS ZNF263 SP3 REST ITGB6 RBMS1 PLA2R1 MIR4785 GC02M160337
GH02G160219 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 -162.1 -162088 11.4 PKNOX1 FOXA2 ZNF48 ZNF766 CBX5 GATA2 ZNF207 FOS SP5 ZHX2 ITGB6 LY75 PLA2R1 LINC02478 RBMS1 CD302 PIR61464
GH02G160287 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.1 -228.7 -228689 8.5 HDGF CTCF CBX3 ZSCAN4 CHD4 MAX SIN3A RAD21 ZNF507 GATA3 ITGB6 PLA2R1 RBMS1 CD302 LINC02478 GC02M160337
GH02G160317 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -255.0 -255017 1.8 HDAC1 ATF1 NFRKB ZNF766 EGR1 ZBTB11 USF2 ZNF592 TFDP1 ZNF589 ITGB6 PLA2R1 GC02M160337 LINC02478
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLA2R1 on UCSC Golden Path with GeneCards custom track

Promoters for PLA2R1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000125234 502 1201 CTCF PHF8 ZNF654 FOXA2 SUZ12 TEAD4 SIN3A RBBP5 RAD21 HDAC2

Genomic Location for PLA2R1 Gene

Chromosome:
2
Start:
159,932,002 bp from pter
End:
160,062,902 bp from pter
Size:
130,901 bases
Orientation:
Minus strand

Genomic View for PLA2R1 Gene

Genes around PLA2R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2R1 Gene

Proteins for PLA2R1 Gene

  • Protein details for PLA2R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13018-PLA2R_HUMAN
    Recommended name:
    Secretory phospholipase A2 receptor
    Protein Accession:
    Q13018
    Secondary Accessions:
    • B2RTU9
    • D3DPB1
    • Q13019
    • Q15095
    • Q53R45
    • Q53RR7

    Protein attributes for PLA2R1 Gene

    Size:
    1463 amino acids
    Molecular mass:
    168600 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2R1 Gene

Post-translational modifications for PLA2R1 Gene

  • The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity).
  • Glycosylation at Asn93, Asn454, and Asn1123
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLA2R1 Gene

Domains & Families for PLA2R1 Gene

Gene Families for PLA2R1 Gene

Suggested Antigen Peptide Sequences for PLA2R1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13018

UniProtKB/Swiss-Prot:

PLA2R_HUMAN :
  • C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
Domain:
  • C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
  • The endocytosis signal probably mediates endocytosis via clathrin-coated pits.
genes like me logo Genes that share domains with PLA2R1: view

Function for PLA2R1 Gene

Molecular function for PLA2R1 Gene

GENATLAS Biochemistry:
phospholipase A2 receptor 1(180kDa),soluble and membrane bound isoforms,expressed in kidney
UniProtKB/Swiss-Prot Function:
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Gene Ontology (GO) - Molecular Function for PLA2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0030246 carbohydrate binding IEA --
GO:0043274 phospholipase binding IEA --
genes like me logo Genes that share ontologies with PLA2R1: view
genes like me logo Genes that share phenotypes with PLA2R1: view

Animal Models for PLA2R1 Gene

MGI Knock Outs for PLA2R1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2R1

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2R1 Gene

Localization for PLA2R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2R1 Gene

Cell membrane; Single-pass type I membrane protein.
Soluble secretory phospholipase A2 receptor: Secreted.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2R1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PLA2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005886 plasma membrane IEA,IDA 12225974
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IDA 15611272
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLA2R1: view

Pathways & Interactions for PLA2R1 Gene

genes like me logo Genes that share pathways with PLA2R1: view

Pathways by source for PLA2R1 Gene

Gene Ontology (GO) - Biological Process for PLA2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IMP 15611272
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0007165 signal transduction IEA --
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IMP 19197340
genes like me logo Genes that share ontologies with PLA2R1: view

No data available for SIGNOR curated interactions for PLA2R1 Gene

Drugs & Compounds for PLA2R1 Gene

No Compound Related Data Available

Transcripts for PLA2R1 Gene

Unigene Clusters for PLA2R1 Gene

Phospholipase A2 receptor 1, 180kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2R1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - -
SP2: - -
SP3:
SP4:

ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for PLA2R1 Gene

GeneLoc Exon Structure for
PLA2R1
ECgene alternative splicing isoforms for
PLA2R1

Expression for PLA2R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2R1 Gene

This gene is overexpressed in Thyroid (x5.8).

Protein differential expression in normal tissues from HIPED for PLA2R1 Gene

This gene is overexpressed in Salivary gland (20.6), Plasma (20.5), Urine (15.6), and Retina (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2R1 Gene



Protein tissue co-expression partners for PLA2R1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLA2R1 Gene:

PLA2R1

SOURCE GeneReport for Unigene cluster for PLA2R1 Gene:

Hs.410477

mRNA Expression by UniProt/SwissProt for PLA2R1 Gene:

Q13018-PLA2R_HUMAN
Tissue specificity: Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level.

Evidence on tissue expression from TISSUES for PLA2R1 Gene

  • Kidney(4.6)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PLA2R1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2R1 Gene

Orthologs for PLA2R1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2R1 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia PLA2R1 34 35
  • 88.76 (n)
cow
(Bos Taurus)
Mammalia PLA2R1 34 35
  • 87.68 (n)
mouse
(Mus musculus)
Mammalia Pla2r1 34 16 35
  • 79.99 (n)
rat
(Rattus norvegicus)
Mammalia Pla2r1 34
  • 79.07 (n)
oppossum
(Monodelphis domestica)
Mammalia PLA2R1 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2R1 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2R1 34 35
  • 66.11 (n)
lizard
(Anolis carolinensis)
Reptilia PLA2R1 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2r1 34
  • 56.99 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100538038 34
  • 52.07 (n)
PLA2R1 35
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clec-48 35
  • 23 (a)
ManyToMany
clec-50 35
  • 23 (a)
ManyToMany
clec-49 35
  • 22 (a)
ManyToMany
clec-53 35
  • 21 (a)
ManyToMany
clec-51 35
  • 20 (a)
ManyToMany
clec-52 35
  • 20 (a)
ManyToMany
clec-148 35
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToMany
Species where no ortholog for PLA2R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2R1 Gene

ENSEMBL:
Gene Tree for PLA2R1 (if available)
TreeFam:
Gene Tree for PLA2R1 (if available)

Paralogs for PLA2R1 Gene

Paralogs for PLA2R1 Gene

(4) SIMAP similar genes for PLA2R1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA2R1: view

Variants for PLA2R1 Gene

Sequence variations from dbSNP and Humsavar for PLA2R1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000047314 -- 160,056,126(+) TGCAG(G/T)TTGTG intron-variant, nc-transcript-variant
rs1000057414 -- 160,019,053(+) TTTAG(A/G)CATAA intron-variant
rs1000112541 -- 160,008,179(+) TAGAT(A/G)CCTGT intron-variant
rs1000177164 -- 160,049,363(+) GCATA(C/T)GGAAC intron-variant
rs1000184543 -- 160,044,731(+) ACCTT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2R1 Gene

Variant ID Type Subtype PubMed ID
dgv2076n106 CNV deletion 24896259
dgv742e199 CNV deletion 23128226
esv1000137 CNV deletion 20482838
esv1565630 CNV deletion 17803354
esv2291297 CNV deletion 18987734
esv2468197 CNV deletion 19546169
esv2596999 CNV deletion 19546169
esv2721035 CNV deletion 23290073
esv3560436 CNV deletion 23714750
esv3593126 CNV loss 21293372
esv5014 CNV loss 18987735
esv8839 CNV loss 19470904
nsv1010774 CNV gain 25217958
nsv1072461 CNV deletion 25765185
nsv1118654 CNV duplication 24896259
nsv1149575 CNV deletion 26484159
nsv213665 CNV deletion 16902084
nsv2997 CNV deletion 18451855
nsv834436 CNV loss 17160897
nsv956657 CNV deletion 24416366

Variation tolerance for PLA2R1 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.29; 88.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2R1 Gene

Human Gene Mutation Database (HGMD)
PLA2R1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2R1 Gene

Disorders for PLA2R1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PLA2R1 Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
membranoproliferative glomerulonephritis
  • chronic glomerulonephritis, lobular
membranous nephropathy
  • membranous glomerulonephritis, antenatal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2R1

Genetic Association Database (GAD)
PLA2R1
Human Genome Epidemiology (HuGE) Navigator
PLA2R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2R1
genes like me logo Genes that share disorders with PLA2R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2R1 Gene

Publications for PLA2R1 Gene

  1. The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. (PMID: 7721806) Ancian P. … Lazdunski M. (J. Biol. Chem. 1995) 2 3 4 64
  2. Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals. (PMID: 7925459) Higashino K. … Arita H. (Eur. J. Biochem. 1994) 2 3 4 64
  3. Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. (PMID: 21323541) Stanescu H.C. … Kleta R. (N. Engl. J. Med. 2011) 3 46 64
  4. Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan. (PMID: 20937089) Liu Y.H. … Tsai F.J. (J. Biomed. Sci. 2010) 3 46 64
  5. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PMID: 19730683) Landa I. … Robledo M. (PLoS Genet. 2009) 3 46 64

Products for PLA2R1 Gene

Sources for PLA2R1 Gene

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