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Aliases for PLA2R1 Gene

Aliases for PLA2R1 Gene

  • Phospholipase A2 Receptor 1 2 3 5
  • 180 KDa Secretory Phospholipase A2 Receptor 3 4
  • C-Type Lectin Domain Family 13 Member C 3 4
  • Phospholipase A2 Receptor 1, 180kDa 2 3
  • Phospholipase A2 Receptor 1, 180kD 2 3
  • M-Type Receptor 3 4
  • CLEC13C 3 4
  • PLA2-R 3 4
  • PLA2R 3 4
  • PLA2G1R 3
  • PLA2IR 3

External Ids for PLA2R1 Gene

Previous GeneCards Identifiers for PLA2R1 Gene

  • GC02M158728
  • GC02M159326
  • GC02M160752
  • GC02M160999
  • GC02M160622
  • GC02M160505
  • GC02M152681
  • GC02M160788

Summaries for PLA2R1 Gene

Entrez Gene Summary for PLA2R1 Gene

  • This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

GeneCards Summary for PLA2R1 Gene

PLA2R1 (Phospholipase A2 Receptor 1) is a Protein Coding gene. Diseases associated with PLA2R1 include Membranoproliferative Glomerulonephritis and Membranous Nephropathy. Among its related pathways are Phagosome and Tuberculosis. GO annotations related to this gene include receptor activity and phospholipase binding. An important paralog of this gene is MRC2.

UniProtKB/Swiss-Prot for PLA2R1 Gene

  • Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Gene Wiki entry for PLA2R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2R1 Gene

Genomics for PLA2R1 Gene

Regulatory Elements for PLA2R1 Gene

Enhancers for PLA2R1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLA2R1 on UCSC Golden Path with GeneCards custom track

Promoters for PLA2R1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLA2R1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2R1 Gene

Chromosome:
2
Start:
159,932,002 bp from pter
End:
160,062,902 bp from pter
Size:
130,901 bases
Orientation:
Minus strand

Genomic View for PLA2R1 Gene

Genes around PLA2R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2R1 Gene

Proteins for PLA2R1 Gene

  • Protein details for PLA2R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13018-PLA2R_HUMAN
    Recommended name:
    Secretory phospholipase A2 receptor
    Protein Accession:
    Q13018
    Secondary Accessions:
    • B2RTU9
    • D3DPB1
    • Q13019
    • Q15095
    • Q53R45
    • Q53RR7

    Protein attributes for PLA2R1 Gene

    Size:
    1463 amino acids
    Molecular mass:
    168600 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2R1 Gene

Proteomics data for PLA2R1 Gene at MOPED

Post-translational modifications for PLA2R1 Gene

  • The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity).
  • Glycosylation at Asn 93, Asn 454, and Asn 1123
  • Modification sites at PhosphoSitePlus

Other Protein References for PLA2R1 Gene

No data available for DME Specific Peptides for PLA2R1 Gene

Domains & Families for PLA2R1 Gene

Gene Families for PLA2R1 Gene

Suggested Antigen Peptide Sequences for PLA2R1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13018

UniProtKB/Swiss-Prot:

PLA2R_HUMAN :
  • C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
Domain:
  • C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
  • The endocytosis signal probably mediates endocytosis via clathrin-coated pits.
  • Contains 8 C-type lectin domains.
  • Contains 1 fibronectin type-II domain.
  • Contains 1 ricin B-type lectin domain.
genes like me logo Genes that share domains with PLA2R1: view

Function for PLA2R1 Gene

Molecular function for PLA2R1 Gene

GENATLAS Biochemistry:
phospholipase A2 receptor 1(180kDa),soluble and membrane bound isoforms,expressed in kidney
UniProtKB/Swiss-Prot Function:
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

Gene Ontology (GO) - Molecular Function for PLA2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 7721806
genes like me logo Genes that share ontologies with PLA2R1: view
genes like me logo Genes that share phenotypes with PLA2R1: view

Animal Models for PLA2R1 Gene

MGI Knock Outs for PLA2R1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2R1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2R1 Gene

Localization for PLA2R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2R1 Gene

Cell membrane; Single-pass type I membrane protein.
Soluble secretory phospholipase A2 receptor: Secreted.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2R1 Gene COMPARTMENTS Subcellular localization image for PLA2R1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLA2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PLA2R1: view

Pathways & Interactions for PLA2R1 Gene

SuperPathways for PLA2R1 Gene

Superpath Contained pathways
1 Phagosome
2 Tuberculosis
genes like me logo Genes that share pathways with PLA2R1: view

Pathways by source for PLA2R1 Gene

2 KEGG pathways for PLA2R1 Gene

Interacting Proteins for PLA2R1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283243%0d%0a9606.ENSP00000393847%0d%0a9606.ENSP00000364252%0d%0a
Selected Interacting proteins: ENSP00000283243 Q13018-PLA2R_HUMAN for PLA2R1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PLA2R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IMP 19197340
GO:0072593 reactive oxygen species metabolic process IDA 19197340
GO:0090238 positive regulation of arachidonic acid secretion ISS --
GO:0090399 replicative senescence IMP 19197340
genes like me logo Genes that share ontologies with PLA2R1: view

No data available for SIGNOR curated interactions for PLA2R1 Gene

Drugs & Compounds for PLA2R1 Gene

No Compound Related Data Available

Transcripts for PLA2R1 Gene

Unigene Clusters for PLA2R1 Gene

Phospholipase A2 receptor 1, 180kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2R1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - -
SP2: - -
SP3:
SP4:

ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for PLA2R1 Gene

GeneLoc Exon Structure for
PLA2R1
ECgene alternative splicing isoforms for
PLA2R1

Expression for PLA2R1 Gene

mRNA expression in normal human tissues for PLA2R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2R1 Gene

This gene is overexpressed in Thyroid (x5.8).

Protein differential expression in normal tissues from HIPED for PLA2R1 Gene

This gene is overexpressed in Salivary gland (20.6), Plasma (20.5), Urine (15.6), and Retina (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2R1 Gene



SOURCE GeneReport for Unigene cluster for PLA2R1 Gene Hs.410477

mRNA Expression by UniProt/SwissProt for PLA2R1 Gene

Q13018-PLA2R_HUMAN
Tissue specificity: Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level.
genes like me logo Genes that share expression patterns with PLA2R1: view

Protein tissue co-expression partners for PLA2R1 Gene

Primer Products

Orthologs for PLA2R1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2R1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2R1 35
  • 87.68 (n)
  • 84.32 (a)
PLA2R1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2R1 35
  • 88.76 (n)
  • 86.04 (a)
PLA2R1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2r1 35
  • 79.99 (n)
  • 74.64 (a)
Pla2r1 16
Pla2r1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2R1 35
  • 99.52 (n)
  • 99.31 (a)
PLA2R1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2r1 35
  • 79.07 (n)
  • 73.61 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA2R1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2R1 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2R1 35
  • 66.11 (n)
  • 56.95 (a)
PLA2R1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2R1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2r1 35
  • 56.99 (n)
  • 46.09 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100538038 35
  • 52.07 (n)
  • 42.56 (a)
PLA2R1 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clec-148 36
  • 19 (a)
ManyToMany
clec-48 36
  • 23 (a)
ManyToMany
clec-49 36
  • 22 (a)
ManyToMany
clec-50 36
  • 23 (a)
ManyToMany
clec-51 36
  • 20 (a)
ManyToMany
clec-52 36
  • 20 (a)
ManyToMany
clec-53 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for PLA2R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2R1 Gene

ENSEMBL:
Gene Tree for PLA2R1 (if available)
TreeFam:
Gene Tree for PLA2R1 (if available)

Paralogs for PLA2R1 Gene

Paralogs for PLA2R1 Gene

(4) SIMAP similar genes for PLA2R1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA2R1: view

Variants for PLA2R1 Gene

Sequence variations from dbSNP and Humsavar for PLA2R1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_037203 -
VAR_037204 -
rs965290 - 160,032,965(-) ATTTC(A/G)TAAGG nc-transcript-variant, reference, missense
rs3749117 - 160,028,931(+) GCCCA(C/T)CCACA nc-transcript-variant, reference, missense
rs35771982 - 160,028,907(-) ATGAA(C/G)ACGCT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLA2R1 Gene

Variant ID Type Subtype PubMed ID
nsv834436 CNV Loss 17160897
nsv875345 CNV Loss 21882294
nsv2997 CNV Loss 18451855
esv2468197 CNV Deletion 19546169
esv2291297 CNV Deletion 18987734
esv2721035 CNV Deletion 23290073
esv5014 CNV Deletion 18987735
nsv213665 CNV Loss 16902084
esv1000137 CNV Deletion 20482838
esv2596999 CNV Deletion 19546169
esv1565630 CNV Deletion 17803354
esv8839 CNV Loss 19470904
dgv742e199 CNV Deletion 23128226

Variation tolerance for PLA2R1 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.29; 88.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2R1 Gene

Human Gene Mutation Database (HGMD)
PLA2R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2R1 Gene

Disorders for PLA2R1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLA2R1 Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
membranoproliferative glomerulonephritis
  • chronic glomerulonephritis, lobular
membranous nephropathy
  • membranous glomerulonephritis, antenatal
membranous glomerulonephritis
  • membranous nephropathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2R1

Genetic Association Database (GAD)
PLA2R1
Human Genome Epidemiology (HuGE) Navigator
PLA2R1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2R1
genes like me logo Genes that share disorders with PLA2R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2R1 Gene

Publications for PLA2R1 Gene

  1. The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. (PMID: 7721806) Ancian P. … Lazdunski M. (J. Biol. Chem. 1995) 2 3 4 67
  2. Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals. (PMID: 7925459) Higashino K. … Arita H. (Eur. J. Biochem. 1994) 2 3
  3. Antiphospholipase A2 Receptor Antibody Levels Predict the Risk of Posttransplantation Recurrence of Membranous Nephropathy. (PMID: 25675198) Quintana L.F. … Campistol J.M. (Transplantation 2015) 3
  4. C-type lectin-like domain and fibronectin-like type II domain of phospholipase A(2) receptor 1 modulate binding and migratory responses to collagen. (PMID: 25724334) Takahashi S. … Kugiyama K. (FEBS Lett. 2015) 3
  5. Diagnostic accuracy of PLA2R autoantibodies and glomerular staining for the differentiation of idiopathic and secondary membranous nephropathy: an updated meta-analysis. (PMID: 25740009) Dai H. … He Y. (Sci Rep 2015) 3

Products for PLA2R1 Gene

Sources for PLA2R1 Gene

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