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Aliases for PLA2G7 Gene

Aliases for PLA2G7 Gene

  • Phospholipase A2 Group VII 2 3 5
  • Phospholipase A2, Group VII (Platelet-Activating Factor Acetylhydrolase, Plasma) 2 3
  • 1-Alkyl-2-Acetylglycerophosphocholine Esterase 3 4
  • 2-Acetyl-1-Alkylglycerophosphocholine Esterase 3 4
  • LDL-Associated Phospholipase A2 3 4
  • Group-VIIA Phospholipase A2 3 4
  • PAF 2-Acylhydrolase 3 4
  • PAF Acetylhydrolase 3 4
  • EC 3.1.1.47 4 63
  • LDL-PLA(2) 3 4
  • GVIIA-PLA2 3 4
  • PAFAH 3 4
  • Lipoprotein-Associated Phospholipase A2 3
  • LDL-PLA2 3
  • EC 3.1.1 63
  • LP-PLA2 3
  • PAFAD 3

External Ids for PLA2G7 Gene

Previous GeneCards Identifiers for PLA2G7 Gene

  • GC06M046674
  • GC06M046718
  • GC06M046719
  • GC06M046780
  • GC06M046395

Summaries for PLA2G7 Gene

Entrez Gene Summary for PLA2G7 Gene

  • The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]

GeneCards Summary for PLA2G7 Gene

PLA2G7 (Phospholipase A2 Group VII) is a Protein Coding gene. Diseases associated with PLA2G7 include platelet-activating factor acetylhydrolase deficiency and atopy. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PAFAH2.

UniProtKB/Swiss-Prot for PLA2G7 Gene

  • Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Tocris Summary for PLA2G7 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G7 Gene

Genomics for PLA2G7 Gene

Regulatory Elements for PLA2G7 Gene

Genomic Location for PLA2G7 Gene

Chromosome:
6
Start:
46,704,201 bp from pter
End:
46,735,701 bp from pter
Size:
31,501 bases
Orientation:
Minus strand

Genomic View for PLA2G7 Gene

Genes around PLA2G7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G7 Gene

Proteins for PLA2G7 Gene

  • Protein details for PLA2G7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13093-PAFA_HUMAN
    Recommended name:
    Platelet-activating factor acetylhydrolase
    Protein Accession:
    Q13093
    Secondary Accessions:
    • A5HTT5
    • Q15692
    • Q5VTT1
    • Q8IVA2

    Protein attributes for PLA2G7 Gene

    Size:
    441 amino acids
    Molecular mass:
    50077 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLA2G7 Gene

neXtProt entry for PLA2G7 Gene

Proteomics data for PLA2G7 Gene at MOPED

Selected DME Specific Peptides for PLA2G7 Gene

Post-translational modifications for PLA2G7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PLA2G7 (PLA2G7/PAF-AH/Lp-PLA2)

Protein Products

  • Enzo Life Sciences proteins for PLA2G7

Domains & Families for PLA2G7 Gene

Gene Families for PLA2G7 Gene

Suggested Antigen Peptide Sequences for PLA2G7 Gene

Graphical View of Domain Structure for InterPro Entry

Q13093

UniProtKB/Swiss-Prot:

PAFA_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PLA2G7: view

Function for PLA2G7 Gene

Molecular function for PLA2G7 Gene

GENATLAS Biochemistry:
phospholipase A2,groupVII,platelet activating factor acetylhydrolase plasma,inhibiting the proinflammatory properties of PAH.The mutation V279 is a risk factor for stroke
UniProtKB/Swiss-Prot CatalyticActivity:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
UniProtKB/Swiss-Prot Function:
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Enzyme Numbers (IUBMB) for PLA2G7 Gene

Gene Ontology (GO) - Molecular Function for PLA2G7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016788 hydrolase activity, acting on ester bonds TAS --
genes like me logo Genes that share ontologies with PLA2G7: view
genes like me logo Genes that share phenotypes with PLA2G7: view

Human Phenotype Ontology for PLA2G7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLA2G7 Gene

MGI Knock Outs for PLA2G7:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for PLA2G7 Gene

Localization for PLA2G7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G7 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G7 Gene COMPARTMENTS Subcellular localization image for PLA2G7 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for PLA2G7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034362 low-density lipoprotein particle IDA 8624782
genes like me logo Genes that share ontologies with PLA2G7: view

Pathways & Interactions for PLA2G7 Gene

genes like me logo Genes that share pathways with PLA2G7: view

Pathways by source for PLA2G7 Gene

Interacting Proteins for PLA2G7 Gene

Gene Ontology (GO) - Biological Process for PLA2G7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034441 plasma lipoprotein particle oxidation IDA 8624782
GO:0044267 cellular protein metabolic process TAS --
GO:0050729 positive regulation of inflammatory response TAS 8624782
genes like me logo Genes that share ontologies with PLA2G7: view

No data available for SIGNOR curated interactions for PLA2G7 Gene

Drugs & Compounds for PLA2G7 Gene

(32) Drugs for PLA2G7 Gene - From: Novoseek, ApexBio, DGIdb, Tocris, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halobetasol Propionate Approved Pharma 0
acetic acid Approved Nutra Full agonist, Agonist 89
(1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE Experimental Pharma Target 0
659032 Investigational Pharma Target 0
Rilapladib Investigational Pharma inhibitor 0

(73) Additional Compounds for PLA2G7 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LysoPC(0:0/18:0)
  • 1-Hydroxy-2-Octadecanoyl-sn-glycero-3-phosphocholine
  • 1-Hydroxy-2-stearoyl-sn-glycero-3-phosphocholine
  • Lysophosphatidylcholine
  • Stearoyl lysophosphatidylcholine
LysoPC(10:0)
  • 1-Capryl-2-lysophosphatidylcholine
  • 1-Capryl-L-alpha-phosphorylcholine
  • 1-Decanoyl-sn-glycero-3-phosphocholine
  • 1-Decanoyl-sn-glycerol-3-phosphorylcholine
  • 1-Decanoyllysolecithin
22248-63-1
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
genes like me logo Genes that share compounds with PLA2G7: view

Transcripts for PLA2G7 Gene

Unigene Clusters for PLA2G7 Gene

Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3: -
SP4:

Relevant External Links for PLA2G7 Gene

GeneLoc Exon Structure for
PLA2G7
ECgene alternative splicing isoforms for
PLA2G7

Expression for PLA2G7 Gene

mRNA expression in normal human tissues for PLA2G7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G7 Gene

This gene is overexpressed in Spleen (x9.2).

Protein differential expression in normal tissues from HIPED for PLA2G7 Gene

This gene is overexpressed in Serum (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G7 Gene



SOURCE GeneReport for Unigene cluster for PLA2G7 Gene Hs.584823

mRNA Expression by UniProt/SwissProt for PLA2G7 Gene

Q13093-PAFA_HUMAN
Tissue specificity: Plasma.
genes like me logo Genes that share expression patterns with PLA2G7: view

Protein tissue co-expression partners for PLA2G7 Gene

Primer Products

In Situ Assay Products

Orthologs for PLA2G7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2G7 35
  • 86.62 (n)
  • 82.77 (a)
PLA2G7 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G7 35
  • 86.24 (n)
  • 81.18 (a)
PLA2G7 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g7 35
  • 75.38 (n)
  • 67.5 (a)
Pla2g7 16
Pla2g7 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G7 35
  • 99.7 (n)
  • 99.32 (a)
PLA2G7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g7 35
  • 74.64 (n)
  • 68.79 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA2G7 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G7 36
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G7 35
  • 63.77 (n)
  • 58.82 (a)
PLA2G7 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G7 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g7 35
  • 61.53 (n)
  • 56.49 (a)
zebrafish
(Danio rerio)
Actinopterygii pla2g7 35
  • 62.81 (n)
  • 57.8 (a)
pla2g7 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea paf-1 37
  • 33 (a)
paf-2 37
  • 34 (a)
paf-1 36
  • 29 (a)
ManyToMany
paf-2 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for PLA2G7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G7 Gene

ENSEMBL:
Gene Tree for PLA2G7 (if available)
TreeFam:
Gene Tree for PLA2G7 (if available)

Paralogs for PLA2G7 Gene

Paralogs for PLA2G7 Gene

(1) SIMAP similar genes for PLA2G7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA2G7: view

Variants for PLA2G7 Gene

Sequence variations from dbSNP and Humsavar for PLA2G7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs76863441 Platelet-activating factor acetylhydrolase deficiency (PAFAD) 46,709,361(+) AATAA(A/C)CGTTG intron-variant, reference, missense
rs1805017 - 46,716,485(-) TGATC(A/G)CCTTG reference, missense
rs1805018 - 46,711,566(-) AGAAA(C/T)AGGGG reference, missense
VAR_011585 Platelet-activating factor acetylhydrolase deficiency (PAFAD)
rs1051931 - 46,705,206(+) TAGCT(A/G)CATTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLA2G7 Gene

Variant ID Type Subtype PubMed ID
nsv885868 CNV Gain 21882294
nsv523148 CNV Loss 19592680
esv2732030 CNV Deletion 23290073
nsv885869 CNV Loss 21882294
nsv885870 CNV Loss 21882294
nsv428147 CNV Gain 18775914
dgv1948e1 CNV Complex 17122850
nsv7894 CNV Loss 18304495

Variation tolerance for PLA2G7 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G7 Gene

HapMap Linkage Disequilibrium report
PLA2G7
Human Gene Mutation Database (HGMD)
PLA2G7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G7 Gene

Disorders for PLA2G7 Gene

MalaCards: The human disease database

(9) MalaCards diseases for PLA2G7 Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
platelet-activating factor acetylhydrolase deficiency
  • pafad
atopy
  • atopic hypersensitivity
asthma
  • asthma, protection against
isolated 17-linked lissencephaly
  • ils
lipoprotein lipase deficiency
  • lipoprotein lipase
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PAFA_HUMAN
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:10733466}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Atopic hypersensitivity (ATOPY) [MIM:147050]: A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma. {ECO:0000269 PubMed:10733466}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM:614278]: An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms. {ECO:0000269 PubMed:8675689, ECO:0000269 PubMed:9245731, ECO:0000269 PubMed:9412624, ECO:0000269 PubMed:9472966, ECO:0000269 PubMed:9759612}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PLA2G7

Genetic Association Database (GAD)
PLA2G7
Human Genome Epidemiology (HuGE) Navigator
PLA2G7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G7
genes like me logo Genes that share disorders with PLA2G7: view

No data available for Genatlas for PLA2G7 Gene

Publications for PLA2G7 Gene

  1. Purification, properties, sequencing, and cloning of a lipoprotein- associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins. (PMID: 8624782) Tew D.G. … Macphee C.H. (Arterioscler. Thromb. Vasc. Biol. 1996) 2 3 4 23 67
  2. Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome. (PMID: 20185515) Fan P. … Bai H. (Hum. Reprod. 2010) 3 23
  3. Novel mechanism for regulation of plasma platelet-activating factor acetylhydrolase expression in mammalian cells. (PMID: 20331434) Gardner A.A. … Stafforini D.M. (Biochem. J. 2010) 3 23
  4. [Activity and distribution of plasma platelet-activating factor acetylhydrolase in polycystic ovary syndrome patients with insulin resistance]. (PMID: 20367923) Wan D.H. … Liu H.W. (Zhonghua Fu Chan Ke Za Zhi 2010) 3 23
  5. Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, platelet-activating factor acetylhydrolase (PAF-AH) in leukocytes and body composition in healthy adults. (PMID: 19500354) Detopoulou P. … Antonopoulou S. (Lipids Health Dis 2009) 3 23

Products for PLA2G7 Gene

Sources for PLA2G7 Gene

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