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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLA2G7 Gene

protein-coding   GIFtS: 71
GCID: GC06M046719

phospholipase A2, group VII (platelet-activating factor...
 Explore 81 diseases affiliated with
PLA2G7 via
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 Human Malady Compendium 
Biological research products
for PLA2G7    

Aliases
for PLA2G7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Phospholipase A2, Group VII (Platelet-Activating Factor Acetylhydrolase,
Plasma)1 2
     PAF 2-Acylhydrolase2 3
PAFAH1 2 3 5     PAF Acetylhydrolase2 3
LDL-PLA21 2     EC 3.1.1.473 8
Group-VIIA Phospholipase A22 3     LP-PLA22
1-Alkyl-2-Acetylglycerophosphocholine Esterase2 3     PAFAD2
2-Acetyl-1-Alkylglycerophosphocholine Esterase2 3     Lipoprotein-Associated Phospholipase A22
LDL-PLA(2)2 3     Platelet-Activating Factor Acetylhydrolase2
GVIIA-PLA21     EC 3.1.18
LDL-Associated Phospholipase A22 3     

External Ids:    HGNC: 90401   Entrez Gene: 79412   Ensembl: ENSG000001460707   OMIM: 6016905   UniProtKB: Q130933   

Export aliases for PLA2G7 gene to outside databases

Previous GC identifers: GC06M046674 GC06M046718 GC06M046780 GC06M046395


Summaries
for PLA2G7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PLA2G7:
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to
biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase
deficiency. Two transcript variants encoding the same protein have been found for this gene.(provided by RefSeq, Dec
2009)

UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093
Function: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the
biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is
inactive against long-chain phospholipids

summary for PLA2G7:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G7 (Lipoprotein-associated phospholipase A2)


Genomic Views
for PLA2G7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLA2G7 gene promoter:
         NF-YA   NF-AT   C/EBPalpha   NF-YB   CBF-B   CBF-A   CP1A   LyF-1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLA2G7 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLA2G7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2-p12   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p21.2-p12

PLA2G7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M046719:  view genomic region     (about GC identifiers)

Start:
 46,671,938 bp from pter      End:
 46,703,430 bp from pter
Size:
 31,493 bases      Orientation:
 minus strand

Proteins
for PLA2G7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093 (See protein sequence)
Recommended Name: Platelet-activating factor acetylhydrolase precursor  
Size: 441 amino acids; 50077 Da
Subcellular location: Secreted, extracellular space
6 PDB 3D structures from and Proteopedia for PLA2G7:
3D59 (3D)        3D5E (3D)        3F96 (3D)        3F97 (3D)        3F98 (3D)        3F9C (3D)    
Secondary accessions: A5HTT5 Q15692 Q5VTT1 Q8IVA2

Explore the universe of human proteins at neXtProt for PLA2G7: NX_Q13093

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13093

    • 4/7 DME Specific Peptides for PLA2G7 (Q13093) (see all 7)
     ASHGFIV  KDFDQWD  VGCTDLM  GHSFGGAT 

    PLA2G7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161829.1  NP_005075.3  

    ENSEMBL proteins: 
     ENSP00000274793   ENSP00000445666   ENSP00000441416   ENSP00000444164  
    Reactome Protein details: Q13093
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: PLA2G7
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    Novus Biologicals PLA2G7 Protein
    Novus Biologicals PLA2G7 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PLA2G7
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0034362low-density lipoprotein particle IDA8624782


    PLA2G7 for ontologies           About GeneDecksing



    PLA2G7 Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PLA2G7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PLA2G7 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR016715 Ac_Ohase_PAF
     IPR005065 PAF_acetylhydro

    Graphical View of Domain Structure for InterPro Entry Q13093

    ProtoNet protein and cluster: Q13093

    2 Blocks protein families:
    IPB005065 Platelet-activating factor acetylhydrolase
    IPB008262 Lipase


    UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family


    Function
    for PLA2G7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093
    Function: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the
    biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is
    inactive against long-chain phospholipids
    Catalytic activity: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine +
    acetate

         Genatlas biochemistry entry for PLA2G7:
    phospholipase A2,groupVII,platelet activating factor acetylhydrolase plasma,inhibiting the proinflammatory properties
    of PAH.The mutation V279 is a risk factor for stroke

    Enzyme Numbers (IUBMB): EC 3.1.1.471 2 EC 3.1.12

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLA2G7 (see all 7)
    OriGene shRNA RFP: PLA2G7
    OriGene siRNA: PLA2G7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PLA2G7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PLA2G7

    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PLA2G7 (NM_005084)
    Sino Biological Human cDNA Clone for PLA2G7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G7 

    Cell Line
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    Search LifeMap BioReagents cell lines for PLA2G7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G7

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity IEA--
    GO:0005543phospholipid binding IDA8624782
    GO:0047499calcium-independent phospholipase A2 activity IDA8624782


    PLA2G7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PLA2G7:
     Decreased Wnt reporter activit 


    Pathways & Interactions
    for PLA2G7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response CD16 signaling in NK cells
    		Immune response CD16 signaling in NK cells1.00
    		Immune response_CD16 signaling in NK cells0.99
    2Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
    		Synthesis, Secretion, and Deacylation of Ghrelin0.46
    		Deacylation of Acyl Ghrelin0.00
    3Lissencephaly gene (LIS1) in neuronal migration and development
    		Lissencephaly gene (LIS1) in neuronal migration and development1.00
    4Chemokine Signaling
    		Chemokine Signaling1.00
    5Activation of cAMP-Dependent PKA
    		cAMP Pathway0.77

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PLA2G7
        Immune response CD16 signaling in NK cells

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLA2G7 (see all 7)
        Chemokine Signaling
    DHA Signaling
    Antioxidant Action of Vitamin-C
    cAMP Pathway
    Phospholipase-C Pathway

    1 GeneGo (Thomson Reuters) Pathway for PLA2G7
        Immune response CD16 signaling in NK cells

    1 BioSystems Pathway for PLA2G7 
        Lissencephaly gene (LIS1) in neuronal migration and development

    4        Reactome Pathways for PLA2G7
        Deacylation of Acyl Ghrelin
    Synthesis, Secretion, and Deacylation of Ghrelin
    Metabolism of proteins
    Peptide hormone metabolism


    2         Kegg Pathways  (Kegg details for PLA2G7):
        Ether lipid metabolism
    Metabolic pathways


    PLA2G7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLA2G7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for PLA2G7 (Q130933 ENSP000002747934) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TUBA1AQ71U363, ENSP000003010714I2D: score=2 STRING: ENSP00000301071
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    GRID2O434243I2D: score=1 
    CHPT1ENSP000002292664STRING: ENSP00000229266
    IGF1ENSP000003026654STRING: ENSP00000302665
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016042lipid catabolic process IEA--
    GO:0034374low-density lipoprotein particle remodeling IDA8624782
    GO:0034440lipid oxidation IDA8624782
    GO:0034441plasma lipoprotein particle oxidation IDA8624782
    GO:0050729positive regulation of inflammatory response TAS8624782


    PLA2G7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PLA2G7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLA2G7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PLA2G7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RHC 80267Diacylglycerol lipase inhibitor[83654-05-1]
    AACOCF3Phospholipase A2 inhibitor[149301-79-1]
    OBAAPhospholipase A2 inhibitor[221632-26-4]
    PACOCF3Phospholipase A2 inhibitor[141022-99-3]

    10/36 HMDB Compounds for PLA2G7 (see all 36)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    LysoPC(0:0/18:0)1-Hydroxy-2-stearoyl-sn-glycero-3-phosphocholine (see all 4)----
    LysoPC(10:0)1-Decanoyllysolecithin (see all 14)22248-63-1--
    LysoPC(14:0)LysoPC(14:0) (see all 9)----
    LysoPC(14:1(9Z))LysoPC(14:1) (see all 17)----
    LysoPC(15:0)LyPC(15:0) (see all 9)----
    LysoPC(16:0)LysoPC(16:0/0:0) (see all 10)----
    LysoPC(16:1(9Z))LyPC(16:1w7/0:0) (see all 17)----
    LysoPC(17:0)LysoPC(17:0) (see all 9)----
    LysoPC(18:0)Lysophosphatidylcholine(18:0/0:0) (see all 9)----

    1 DrugBank Compound for PLA2G7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE-- --target--10592235

    10/57 Novoseek chemical compound relationships for PLA2G7 gene (see all 57)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxpl 84.5 6 12573364 (2), 17067985 (2), 16843649 (1)
    1-alkyl-2-acetyl-sn-glycero-3-phosphocholine 77.6 2 9392426 (1)
    lysophosphatidylcholine 72 20 19797705 (3), 8624782 (2), 9263748 (2), 11518762 (2) (see all 10)
    phospholipid 70 16 12466264 (2), 1321830 (1), 7937948 (1), 18838739 (1) (see all 15)
    aebsf 65.4 7 9195924 (1), 9626586 (1), 16603612 (1)
    diisopropylfluorophosphate 64.6 7 8301198 (2), 9195924 (2), 8972457 (1)
    phenylacetate 61.1 5 15163466 (1), 16079929 (1), 11171072 (1), 11834533 (1)
    paraoxon 60.1 6 15163466 (1), 8537378 (1), 16079929 (1), 11834533 (1) (see all 5)
    phosphatidylcholine 57.1 18 19667981 (1), 10737702 (1), 15306175 (1), 15607900 (1) (see all 10)
    mafp 53.1 5 14560038 (1), 15937147 (1), 17693621 (1)

    Search CenterWatch for drugs/clinical trials and news about PLA2G7 / PAFA 

    Transcripts
    for PLA2G7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PLA2G7 gene (2 alternative transcripts): 
    NM_001168357.1  NM_005084.3  

    Unigene Cluster for PLA2G7:

    Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
    Hs.584823  [show with all ESTs]
    Unigene Representative Sequence: NM_005084
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274793(uc010jzf.3) ENST00000537365(uc021zae.1) ENST00000538237(uc011dwd.1 uc011dwe.1)
    ENST00000541026

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK290381.1 AK294471.1 AK297066.1 BC025674.1 BC038452.1 U20157.1 U24577.1 

    2 DOTS entries:

    DT.109680  DT.100019446 

    24/40 AceView cDNA sequences (see all 40):

    AL554852 CR615354 CR608291 CR608325 U20157 BC038452 AL549288 BI964070 
    BG530083 AI424439 U24577 AA298064 BM788963 CK903738 AL575852 BI768378 
    BI963794 BQ011547 AL552617 AI770111 AA302965 CK903737 AW071677 CA335136 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G7    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                    
    SP2:        -     -                                                                     
    SP3:                    -                                                               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for PLA2G7

    Expression
    for PLA2G7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLA2G7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTACAGAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PLA2G7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    BrainCerebral CortexBrain
    BrainMedulla OblongataBrain
    EyeLensEye
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PLA2G7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLA2G7

    SOURCE GeneReport for Unigene cluster: Hs.584823

    UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093
    Tissue specificity: Plasma

        SABiosciences Expression via Pathway-Focused PCR Array including PLA2G7: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    Orthologs
    for PLA2G7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PLA2G7 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pla2g71 , 5 phospholipase A2, group VII (platelet-activating factor more1, 5 75.38(n)1
    67.5(a)1    		   17 (19.74 cM)5
    272261  NM_013737.51  NP_038765.21 
     435680985 
    chicken
    (Gallus gallus)    		 Aves PLA2G71 phospholipase A2, group VII (platelet-activating factor more 65.13(n)
    60.16(a)    		   395816  NM_204969.1  NP_990300.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PLA2G76
    		 --
    		 58(a)
    		 1 ↔ 1
    		 1(138537910-138561589)
    zebrafish
    (Danio rerio)    		 Actinopterygii pla2g71 phospholipase A2, group VII (platelet-activating factor more 62.9(n)
    57.53(a)    		   406470  NM_213189.1  NP_998354.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea paf-23   -- 34(a)
    (best of 2)    		   X(4326857-4329627)   --


    ENSEMBL Gene Tree for PLA2G7 (if available)
    TreeFam Gene Tree for PLA2G7 (if available) 

    Paralogs
    for PLA2G7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLA2G7 gene
    PAFAH22  
    1 SIMAP similar gene for PLA2G7 using alignment to 3 protein entries:     PAFA_HUMAN (see all proteins):
    PAFAH2

    PLA2G7 for paralogs           About GeneDecksing



    Genomic Variants
    for PLA2G7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/792 NCBI SNPs in PLA2G7 are shown (see all 792)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs768634411,2
    		C,F,pathogenic68135438(+) AATAAC/ACGTTG 4 /V /F mis11Minor allele frequency- A:0.18EA 120
    rs10519311,2
    		C,F,A,H,other46672943(+) TAGCTA/GCATTT 4 A V mis138Minor allele frequency- N:0.00EA MN NA NS WA CSA EU 12100
    rs18050181,2
    		C,F,O,A,H,other46679303(-) AGAAAT/CAGGGG 4 /T /I mis139Minor allele frequency- C:0.13EA MN NA NS WA CSA EU 13038
    rs764474831,2
    		--46395222(+) TGGGAT/GTTTGC 2 -- ds5001 int12Minor allele frequency- G:0.04CSA WA 120
    rs1487744571,2
    		F--46395317(+) ATTTAG/TGCTGA 2 -- int1 ds50011Minor allele frequency- T:0.00NS 1316
    rs1513262201,2
    		F--46395411(+) GCCTAC/TATTTT 2 -- ut311Minor allele frequency- T:0.00NS 1352
    rs1453439481,2
    		F--46395453(+) CTCTCT/ACTCTC 2 -- ut311Minor allele frequency- A:0.00NS 1352
    rs1505417391,2
    		F--46395531(+) GACTTT/ATAAAA 2 -- ut311Minor allele frequency- A:0.00NS 1346
    rs1402683111,2
    		C,F,--46395600(+) GTTGAT/CTGGTT 4 /N /S mis11Minor allele frequency- C:0.00NA 4534
    rs1452902181,2
    		C,F,--46395635(+) AGATTC/ATCATC 4 /E /D mis11Minor allele frequency- A:0.00NA 4532

    HapMap Linkage Disequilibrium report for PLA2G7 (46671938 - 46703430 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PLA2G7
         1 CNV: 3611
    Human Gene Mutation Database (HGMD): PLA2G7

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    Disorders / Diseases
    for PLA2G7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PLA2G7 for disorders           About GeneDecksing

    OMIM gene information: 601690   
    OMIM disorders: 600807  147050  
    UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093
  • Defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM:614278].
    • An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. Asthmatic individuals
    affected by this condition may manifest severe respiratory symptoms
  • Defects in PLA2G7 are a cause of susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic
    • disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely
    attributed to the interactions among many genes and between these genes and the environment. It is characterized by
    recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. Note=PLA2G7
    variants can be a risk factor for the development of asthma and PLA2G7 may act as a modifier gene that modulates the
    severity of this disease
  • Defects in PLA2G7 are a cause of susceptibility to atopic hypersensitivity (ATOPY) [MIM:147050]. A condition
    • characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic
    rhinitis and allergic asthma

    20/81 diseases for PLA2G7 (see all 81):    About MalaCards
    platelet-activating factor acetylhydrolase deficiency    miller-dieker lissencephaly    perinatal necrotizing enterocolitis    spinal cord injury
    lipoprotein lipase deficiency    hemolytic-uremic syndrome    arterial occlusive disease    peripheral arterial occlusive disease
    polycystic ovary syndrome    abdominal aortic aneurysm    bronchopulmonary dysplasia    diabetes mellitus
    type 2 diabetes mellitus    aortic aneurysm    type 1 diabetes mellitus    coronary heart disease
    inflammatory bowel disease    abetalipoproteinemia    beta thalassemia    dilated cardiomyopathy

    3 diseases from the University of Copenhagen DISEASES database for PLA2G7:
    Coronary heart disease     Atherosclerosis     Cerebrovascular accident

    10/67 Novoseek disease relationships for PLA2G7 gene (see all 67)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lissencephaly sequence, isolated 77.7 2 9729401 (1), 16510495 (1)
    atherosclerosis 65.3 53 11369691 (5), 19797705 (3), 15166791 (3), 12428682 (2) (see all 27)
    cerebral thrombosis 55.6 2 1636183 (1), 1414232 (1)
    inflammation 54.2 47 15710755 (3), 18949548 (3), 19797705 (3), 17251670 (2) (see all 33)
    enterocolitis necrotizing 46.6 2 9396557 (1), 8228643 (1)
    coronary artery disease 39.9 18 15115767 (2), 15710755 (2), 15166791 (2), 10856534 (1) (see all 14)
    acute respiratory distress 38.1 6 12794395 (2), 12626982 (1), 15818104 (1), 15187544 (1)
    abetalipoproteinemia 37.8 1 9392426 (1)
    atherosclerotic plaque 35 3 20065996 (1), 11788123 (1), 15148590 (1)
    respiratory distress syndrome 34.6 7 12794395 (2), 12626982 (1), 15187544 (1), 15818104 (1) (see all 5)

    Genetic Association Database (GAD): PLA2G7
    Human Genome Epidemiology (HuGE) Navigator: PLA2G7 (44 documents)

    Export disorders for PLA2G7 gene to outside databases

    Publications
    for PLA2G7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLA2G7 gene, integrated from 9 sources (see all 444):
    (articles sorted by number of sources associating them with PLA2G7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins. (PubMed id 8624782)1, 2, 3, 9 Tew D.G....Macphee C.H. (1996)
    2. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. (PubMed id 7700381)1, 2, 3, 9 Tjoelker L.W.... Gray P.W. (1995)
    3. Platelet-activating factor acetylhydrolase is not associated with carotid intima-media thickness in hypercholesterolemic Sicilian individuals. (PubMed id 15364890)1, 4, 9 Campo S....Saitta A. (2004)
    4. Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. (PubMed id 15115767)1, 4, 9 Ninio E....Tiret L. (2004)
    5. The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. (PubMed id 10733466)1, 2, 9 Kruse S....Deichmann K.A. (2000)
    6. Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. (PubMed id 18784071)1, 2, 9 Samanta U. and Bahnson B.J. (2008)
    7. Allelic association analysis of phospholipase A2 genes with schizophrenia. (PubMed id 15318030)1, 4, 9 Junqueira R....Vallada H. (2004)
    8. Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. (PubMed id 11807372)1, 4, 9 Unno N....Nakamura S. (2002)
    9. Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm. (PubMed id 11810302)1, 4, 9 Ito T....Ogawa H. (2002)
    10. Lack of evidence for associations between plasma platelet-activating factor acetylhydrolase deficiency and schizophrenia. (PubMed id 11850055)1, 4, 9 Ohtsuki T....Arinami T. (2002)

    External Searches for PLA2G7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PLA2G7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7941 HGNC: 9040 AceView: PLA2G7 Ensembl:ENSG00000146070 euGenes: HUgn7941
    ECgene: PLA2G7 Kegg: 7941 H-InvDB: PLA2G7

    Other Databases showing PLA2G7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PLA2G7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLA2G7 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/pla2g7/

    Intellectual Property
    for PLA2G7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PLA2G7 gene:
    Search GeneIP for patents involving PLA2G7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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