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PLA2G7 Gene

protein-coding   GIFtS: 72
GCID: GC06M046719

Phospholipase A2, Group VII (Platelet-Activating Factor...

  See PLA2G7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase A2, Group VII (Platelet-Activating Factor
Acetylhydrolase, Plasma)1 2
     PAF Acetylhydrolase2 3
PAFAH2 3 5     EC 3.1.1.473 8
Group-VIIA Phospholipase A22 3     PAFAD2 5
1-Alkyl-2-Acetylglycerophosphocholine Esterase2 3     LDL-PLA22
2-Acetyl-1-Alkylglycerophosphocholine Esterase2 3     LP-PLA22
LDL-PLA(2)2 3     Lipoprotein-Associated Phospholipase A22
gVIIA-PLA22 3     Platelet-Activating Factor Acetylhydrolase2
LDL-Associated Phospholipase A22 3     EC 3.1.18
PAF 2-Acylhydrolase2 3     

External Ids:    HGNC: 90401   Entrez Gene: 79412   Ensembl: ENSG000001460707   OMIM: 6016905   UniProtKB: Q130933   

Export aliases for PLA2G7 gene to outside databases

Previous GC identifers: GC06M046674 GC06M046718 GC06M046780 GC06M046395


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLA2G7 Gene:
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor
to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase
deficiency. Two transcript variants encoding the same protein have been found for this gene.(provided by RefSeq,
Dec 2009)

GeneCards Summary for PLA2G7 Gene:
PLA2G7 (phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)) is a protein-coding gene. Diseases associated with PLA2G7 include platelet-activating factor acetylhydrolase deficiency, and aortic atherosclerosis. GO annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PAFAH2.

UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093
Function: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the
biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is
inactive against long-chain phospholipids

summary for PLA2G7 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G7 (Lipoprotein-associated phospholipase A2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLA2G7 gene promoter:
         NF-YA   NF-AT   C/EBPalpha   NF-YB   CBF-B   CBF-A   CP1A   LyF-1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2G7 promoter sequence
   Search Chromatin IP Primers for PLA2G7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLA2G7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2-p12   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p21.2-p12

PLA2G7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M046719:  view genomic region     (about GC identifiers)

Start:
46,671,938 bp from pter      End:
46,703,430 bp from pter
Size:
31,493 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093 (See protein sequence)
Recommended Name: Platelet-activating factor acetylhydrolase precursor  
Size: 441 amino acids; 50077 Da
6 PDB 3D structures from and Proteopedia for PLA2G7:
3D59 (3D)        3D5E (3D)        3F96 (3D)        3F97 (3D)        3F98 (3D)        3F9C (3D)    
Secondary accessions: A5HTT5 Q15692 Q5VTT1 Q8IVA2

Explore the universe of human proteins at neXtProt for PLA2G7: NX_Q13093

Explore proteomics data for PLA2G7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn423, Asn433
  • Selected DME Specific Peptides for PLA2G7 (Q13093) (see all 7)
     ASHGFIV  KDFDQWD  VGCTDLM  GHSFGGAT 


    See PLA2G7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161829.1  NP_005075.3  

    ENSEMBL proteins: 
     ENSP00000274793   ENSP00000445666   ENSP00000441416   ENSP00000444164  
    Reactome Protein details: Q13093

    PLA2G7 Human Recombinant Protein Products:

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    OriGene Purified Protein for PLA2G7
    OriGene Protein Over-expression Lysate for PLA2G7
    OriGene Custom MassSpec
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    Novus Biologicals PLA2G7 Protein
    Novus Biologicals PLA2G7 Lysate
    Sino Biological Recombinant Protein for PLA2G7
    Sino Biological Cell Lysate for PLA2G7
    ProSpec Recombinant Protein for PLA2G7
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PLA2G7 

     
    antibodies-online proteins for PLA2G7 (20 products) 

     
    antibodies-online peptides for PLA2G7

    PLA2G7 Antibody Products:

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    PLA2G7 Assay Products:

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    antibodies-online kits for PLA2G7 (41 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: PLA2-G7
    Phospholipase A2

    2 InterPro protein domains:
     IPR016715 PAF_acetylhydro_eukaryote
     IPR005065 PAF_acetylhydro

    Graphical View of Domain Structure for InterPro Entry Q13093

    ProtoNet protein and cluster: Q13093

    2 Blocks protein domains:
    IPB005065 Platelet-activating factor acetylhydrolase
    IPB008262 Lipase


    UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family


    Find genes that share domains with PLA2G7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAFA_HUMAN, Q13093
    Function: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the
    biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is
    inactive against long-chain phospholipids
    Catalytic activity: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine +
    acetate

         Genatlas biochemistry entry for PLA2G7:
    phospholipase A2,groupVII,platelet activating factor acetylhydrolase plasma,inhibiting the proinflammatory
    properties of PAH.The mutation V279 is a risk factor for stroke

         Enzyme Numbers (IUBMB): EC 3.1.1.471 2 EC 3.1.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity IEA--
    GO:0005543phospholipid binding IDA8624782
    GO:0047499calcium-independent phospholipase A2 activity IDA8624782
    GO:0047746chlorophyllase activity ----
         
    Find genes that share ontologies with PLA2G7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PLA2G7:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLA2G7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLA2G7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLA2G7

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLA2G7:
    hsa-mir-124-3p (MIRT022422), hsa-mir-335-5p (MIRT017286)

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    Search for qRT-PCR Assays for microRNAs that regulate PLA2G7
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PLA2G7

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PLA2G7 (NM_005084)
    Sino Biological Human cDNA Clone for PLA2G7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G7

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAFA_HUMAN, Q13093: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum3
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ----
    GO:0005737cytoplasm IEA--
    GO:0034362low-density lipoprotein particle IDA8624782

    Find genes that share ontologies with PLA2G7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLA2G7 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Synthesis, Secretion, and Deacylation of Ghrelin0.00
    2Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    3Apoptotic Pathways in Synovial Fibroblasts
    DHA Signaling0.74
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    5Phospholipase-C Pathway
    Phospholipase-C Pathway0.56


    Find genes that share SuperPaths with PLA2G7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLA2G7 (see all 7)
        Chemokine Signaling
    DHA Signaling
    Antioxidant Action of Vitamin-C
    cAMP Pathway
    Phospholipase-C Pathway

    1 GeneGo (Thomson Reuters) Pathway for PLA2G7
        Immune response CD16 signaling in NK cells

    1 BioSystems Pathway for PLA2G7
        Lissencephaly gene (LIS1) in neuronal migration and development


    1 Reactome Pathway for PLA2G7
        Synthesis, secretion, and deacylation of Ghrelin


    2 Kegg Pathways  (Kegg details for PLA2G7):
        Ether lipid metabolism
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Array including PLA2G7: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLA2G7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLA2G7 (Q130933 ENSP000002747934) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TUBA1AQ71U363, ENSP000003010714I2D: score=2 STRING: ENSP00000301071
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    GRID2O434243I2D: score=1 
    CHPT1ENSP000002292664STRING: ENSP00000229266
    IGF1ENSP000003026654STRING: ENSP00000302665
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015996chlorophyll catabolic process ----
    GO:0016042lipid catabolic process IEA--
    GO:0034374low-density lipoprotein particle remodeling IDA8624782
    GO:0034440lipid oxidation IDA8624782
    GO:0034441plasma lipoprotein particle oxidation IDA8624782

    Find genes that share ontologies with PLA2G7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PLA2G7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLA2G7 (see all 36)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    LysoPC(0:0/18:0)1-Hydroxy-2-stearoyl-sn-glycero-3-phosphocholine (see all 4)----
    LysoPC(10:0)1-Decanoyllysolecithin (see all 14)22248-63-1--
    LysoPC(14:0)LysoPC(14:0) (see all 9)----
    LysoPC(14:1(9Z))LysoPC(14:1) (see all 17)----
    LysoPC(15:0)LyPC(15:0) (see all 9)----
    LysoPC(16:0)LysoPC(16:0/0:0) (see all 10)----
    LysoPC(16:1(9Z))LyPC(16:1w7/0:0) (see all 17)----
    LysoPC(17:0)LysoPC(17:0) (see all 9)----
    LysoPC(18:0)Lysophosphatidylcholine(18:0/0:0) (see all 9)----

    1 DrugBank Compound for PLA2G7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PLA2G7 gene (see all 57)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxpl 84.5 6 12573364 (2), 17067985 (2), 16843649 (1)
    1-alkyl-2-acetyl-sn-glycero-3-phosphocholine 77.6 2 9392426 (1)
    lysophosphatidylcholine 72 20 19797705 (3), 8624782 (2), 9263748 (2), 11518762 (2) (see all 10)
    phospholipid 70 16 12466264 (2), 1321830 (1), 7937948 (1), 18838739 (1) (see all 15)
    aebsf 65.4 7 9195924 (1), 9626586 (1), 16603612 (1)
    diisopropylfluorophosphate 64.6 7 8301198 (2), 9195924 (2), 8972457 (1)
    phenylacetate 61.1 5 15163466 (1), 16079929 (1), 11171072 (1), 11834533 (1)
    paraoxon 60.1 6 15163466 (1), 8537378 (1), 16079929 (1), 11834533 (1) (see all 5)
    phosphatidylcholine 57.1 18 19667981 (1), 10737702 (1), 15306175 (1), 15607900 (1) (see all 10)
    mafp 53.1 5 14560038 (1), 15937147 (1), 17693621 (1)



    Find genes that share compounds with PLA2G7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLA2G7 gene (2 alternative transcripts): 
    NM_001168357.1  NM_005084.3  

    Unigene Cluster for PLA2G7:

    Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
    Hs.584823  [show with all ESTs]
    Unigene Representative Sequence: NM_005084
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274793(uc010jzf.3) ENST00000537365(uc021zae.1) ENST00000538237(uc011dwd.1 uc011dwe.1)
    ENST00000541026
    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): PLA2G7 (NM_005084)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G7
    Primer
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    OriGene qPCR primer pairs and template standards for PLA2G7
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLA2G7
      QuantiTect SYBR Green Assays in human, mouse, rat PLA2G7
      QuantiFast Probe-based Assays in human, mouse, rat PLA2G7

    Additional mRNA sequence: 

    AK290381.1 AK294471.1 AK297066.1 BC025674.1 BC038452.1 U20157.1 U24577.1 

    2 DOTS entries:

    DT.109680  DT.100019446 

    Selected AceView cDNA sequences (see all 40):

    CR608325 U20157 CR615354 CR608291 AL554852 AL549288 BC038452 AI424439 
    AL575852 CK903738 AA302965 BG530083 AI770111 AW071677 CA335136 NM_005084 
    BI964070 AI343491 CA312081 BQ011547 CK903737 AL552617 BM788963 BC025674 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G7    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                    
    SP2:        -     -                                                                     
    SP3:                    -                                                               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for PLA2G7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PLA2G7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACAGAACT
    PLA2G7 Expression
    About this image


    PLA2G7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Lens
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Cerebellum
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
    PLA2G7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLA2G7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584823

    UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093
    Tissue specificity: Plasma

        Pathway & Disease-focused RT2 Profiler PCR Array including PLA2G7: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLA2G7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2g71 , 5 phospholipase A2, group VII (platelet-activating factor more1, 5 75.38(n)1
    67.5(a)1
      17 (19.74 cM)5
    272261  NM_013737.51  NP_038765.21 
     435680985 
    chicken
    (Gallus gallus)
    Aves PLA2G71 phospholipase A2, group VII (platelet-activating factor more 63.77(n)
    58.82(a)
      395816  NM_204969.1  NP_990300.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLA2G76
    phospholipase A2, group VII (platelet-activating f...
    58(a)
    1 ↔ 1
    1(138537647-138563798)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pla2g71 phospholipase A2, group VII (platelet-activating factor more 61.53(n)
    56.49(a)
      550021  NM_001017267.2  NP_001017267.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pla2g71 phospholipase A2, group VII (platelet-activating factor more 62.81(n)
    57.8(a)
      406470  NM_213189.1  NP_998354.1 
    worm
    (Caenorhabditis elegans)
    Secernentea paf-23   -- 34(a)
    (best of 2)
      X(4326857-4329627)   --


    ENSEMBL Gene Tree for PLA2G7 (if available)
    TreeFam Gene Tree for PLA2G7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLA2G7 gene
    PAFAH22  
    1 SIMAP similar gene for PLA2G7 using alignment to 3 protein entries:     PAFA_HUMAN (see all proteins):
    PAFAH2

    Find genes that share paralogs with PLA2G7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLA2G7 (see all 915)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs168749541,2,4
    Platelet-activating factor acetylhydrolase deficiency (PAFAD)4--see VAR_0042682 mis40--------
    VAR_0115854
    Platelet-activating factor acetylhydrolase deficiency (PAFAD)4--see VAR_0115852 Q R mis40--------
    rs768634411,2
    C,Fpathogenic146588081(+) AATAAC/ACGTTG 4 /V /F mis15Minor allele frequency- A:0.08NS EA 540
    rs10519311,2,,4
    C,F,A,Hother146583926(+) TAGCTA/GCATTT 4 A V mis138Minor allele frequency- N:0.00EA MN NA NS WA CSA EU 12100
    rs18050181,2,,4
    C,F,O,A,Hother146590286(-) AGAAAT/CAGGGG 4 /T /I mis139Minor allele frequency- C:0.13EA MN NA NS WA CSA EU 13038
    rs1813008501,2
    --46582632(+) AAAAAA/TTACCA 2 -- int1 ds50010--------
    rs1852697221,2
    --46582802(+) GCTGCC/TAAATT 2 -- int1 ds50010--------
    rs764474831,2
    C,F--46582933(+) TGGGAT/GTTTGC 2 -- int1 ds50012Minor allele frequency- G:0.04CSA WA 120
    rs1487744571,2
    F--46583028(+) ATTTAG/TGCTGA 2 -- int1 ds50011Minor allele frequency- T:0.00NS 1316
    rs1513262201,2
    F--46583122(+) GCCTAC/TATTTT 2 -- ut311Minor allele frequency- T:0.00NS 1352

    HapMap Linkage Disequilibrium report for PLA2G7 (46671938 - 46703430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PLA2G7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732030CNV Deletion23290073
    nsv885870CNV Loss21882294
    nsv523148CNV Loss19592680
    nsv885869CNV Loss21882294
    nsv7894CNV Loss18304495
    nsv428147CNV Gain18775914
    nsv885868CNV Gain21882294
    dgv1948e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): PLA2G7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLA2G7
    DNA2.0 Custom Variant and Variant Library Synthesis for PLA2G7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601690   
    OMIM disorders: 614278  600807  147050  
    UniProtKB/Swiss-Prot: PAFA_HUMAN, Q13093
  • Platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM:614278]: An enzymatic deficiency that
    results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states
    including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may
    manifest aggravated respiratory symptoms. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is
    a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many
    genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal
    dyspnea, with wheezing due to spasmodic contraction of the bronchi. Note=Disease susceptibility is associated
    with variations affecting the gene represented in this entry
  • Atopic hypersensitivity (ATOPY) [MIM:147050]: A condition characterized by predisposition to develop
    hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 10 diseases for PLA2G7:    
    About MalaCards
    platelet-activating factor acetylhydrolase deficiency    aortic atherosclerosis    atopy    asthma
    pleurisy    hfe-associated hereditary hemochromatosis    lissencephaly    bronchopulmonary dysplasia
    coronary artery disease    atherosclerosis

    4 diseases from the University of Copenhagen DISEASES database for PLA2G7:
    Lissencephaly     Atherosclerosis     Coronary heart disease     Cerebrovascular accident

    Find genes that share disorders with PLA2G7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PLA2G7 gene (see all 67)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lissencephaly sequence, isolated 77.7 2 9729401 (1), 16510495 (1)
    atherosclerosis 65.3 53 11369691 (5), 19797705 (3), 15166791 (3), 12428682 (2) (see all 27)
    cerebral thrombosis 55.6 2 1636183 (1), 1414232 (1)
    inflammation 54.2 47 15710755 (3), 18949548 (3), 19797705 (3), 17251670 (2) (see all 33)
    enterocolitis necrotizing 46.6 2 9396557 (1), 8228643 (1)
    coronary artery disease 39.9 18 15115767 (2), 15710755 (2), 15166791 (2), 10856534 (1) (see all 14)
    acute respiratory distress 38.1 6 12794395 (2), 12626982 (1), 15818104 (1), 15187544 (1)
    abetalipoproteinemia 37.8 1 9392426 (1)
    atherosclerotic plaque 35 3 20065996 (1), 11788123 (1), 15148590 (1)
    respiratory distress syndrome 34.6 7 12794395 (2), 12626982 (1), 15187544 (1), 15818104 (1) (see all 5)

    Genetic Association Database (GAD): PLA2G7
    Human Genome Epidemiology (HuGE) Navigator: PLA2G7 (44 documents)

    Export disorders for PLA2G7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLA2G7 gene, integrated from 10 sources (see all 463):
    (articles sorted by number of sources associating them with PLA2G7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, properties, sequencing, and cloning of a lipoprotein- associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins. (PubMed id 8624782)1, 2, 3, 9 Tew D.G.... Macphee C.H. (Arterioscler. Thromb. Vasc. Biol. 1996)
    2. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. (PubMed id 7700381)1, 2, 3, 9 Tjoelker L.W.... Gray P.W. (Nature 1995)
    3. Platelet-activating factor acetylhydrolase is not associated with carotid intima-media thickness in hypercholesterolemic Sicilian individuals. (PubMed id 15364890)1, 4, 9 Campo S....Saitta A. (Clin. Chem. 2004)
    4. Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. (PubMed id 15115767)1, 4, 9 Ninio E....Tiret L. (Hum. Mol. Genet. 2004)
    5. Inter-individual variability of plasma PAF-acetylhydrolase activity in ARDS patients and PAFAH genotype. (PubMed id 19583678)1, 4, 9 Li S....Yates C.R. (J Clin Pharm Ther 2009)
    6. Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets. (PubMed id 18204052)1, 4, 9 Sutton B.S....Hauser E.R. (Hum. Mol. Genet. 2008)
    7. Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome. (PubMed id 20185515)1, 4, 9 Fan P....Bai H. (Hum. Reprod. 2010)
    8. Association of PLA2G7 polymorphisms with carotid atherosclerosis in hypertensive Japanese. (PubMed id 19763134)1, 4, 9 Miwa Y....Kawano Y. (Hypertens. Res. 2009)
    9. The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. (PubMed id 10733466)1, 2, 9 Kruse S....Deichmann K.A. (Am. J. Hum. Genet. 2000)
    10. PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry. (PubMed id 20479152)1, 4, 9 Casas J.P....Talmud P.J. (Circulation 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7941 HGNC: 9040 AceView: PLA2G7 Ensembl:ENSG00000146070 euGenes: HUgn7941
    ECgene: PLA2G7 Kegg: 7941 H-InvDB: PLA2G7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PLA2G7 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/pla2g7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLA2G7 gene:
    Search GeneIP for patents involving PLA2G7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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