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Aliases for PLA2G6 Gene

Aliases for PLA2G6 Gene

  • Phospholipase A2 Group VI 2 3 5
  • Intracellular Membrane-Associated Calcium-Independent Phospholipase A2 Beta 3 4
  • Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) 2 3
  • Patatin-Like Phospholipase Domain-Containing Protein 9 3 4
  • Neurodegeneration With Brain Iron Accumulation 2 2 3
  • IPLA2-Beta 3 4
  • GVI PLA2 3 4
  • CaI-PLA2 3 4
  • PNPLA9 3 4
  • 85 KDa Calcium-Independent Phospholipase A2 3
  • Group VI Phospholipase A2 4
  • EC 3.1.1.4 4
  • IPLA2-VIA 3
  • IPLA2beta 3
  • NBIA2A 3
  • NBIA2B 3
  • PARK14 3
  • PLPLA9 4
  • INAD1 3
  • NBIA2 3
  • IPLA2 3
  • PLA2 3
  • GVI 3

External Ids for PLA2G6 Gene

Previous GeneCards Identifiers for PLA2G6 Gene

  • GC22M035122
  • GC22M036750
  • GC22M036827
  • GC22M038507
  • GC22M021473
  • GC22M038395
  • GC22M038519

Summaries for PLA2G6 Gene

Entrez Gene Summary for PLA2G6 Gene

  • The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]

GeneCards Summary for PLA2G6 Gene

PLA2G6 (Phospholipase A2 Group VI) is a Protein Coding gene. Diseases associated with PLA2G6 include parkinson disease 14, autosomal recessive and infantile neuroaxonal dystrophy 1. Among its related pathways are Metabolism and Immune System. GO annotations related to this gene include calmodulin binding and ATP-dependent protein binding. An important paralog of this gene is PNPLA8.

UniProtKB/Swiss-Prot for PLA2G6 Gene

  • Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.

  • Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.

Tocris Summary for PLA2G6 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G6 Gene

Genomics for PLA2G6 Gene

Regulatory Elements for PLA2G6 Gene

Genomic Location for PLA2G6 Gene

Chromosome:
22
Start:
38,111,495 bp from pter
End:
38,205,690 bp from pter
Size:
94,196 bases
Orientation:
Minus strand

Genomic View for PLA2G6 Gene

Genes around PLA2G6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G6 Gene

Proteins for PLA2G6 Gene

  • Protein details for PLA2G6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60733-PLPL9_HUMAN
    Recommended name:
    85/88 kDa calcium-independent phospholipase A2
    Protein Accession:
    O60733
    Secondary Accessions:
    • A8K597
    • B0QYE8
    • O75645
    • Q8N452
    • Q9UG29
    • Q9UIT0
    • Q9Y671

    Protein attributes for PLA2G6 Gene

    Size:
    806 amino acids
    Molecular mass:
    89903 Da
    Quaternary structure:
    • Forms large oligomeric 270-350 kDa structures.

    Alternative splice isoforms for PLA2G6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G6 Gene

Proteomics data for PLA2G6 Gene at MOPED

Post-translational modifications for PLA2G6 Gene

  • Ubiquitination at Lys 719
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PLA2G6 Gene

Domains & Families for PLA2G6 Gene

Graphical View of Domain Structure for InterPro Entry

O60733

UniProtKB/Swiss-Prot:

PLPL9_HUMAN :
  • Contains 1 patatin domain.
  • Contains 7 ANK repeats.
Domain:
  • Contains 1 patatin domain.
Similarity:
  • Contains 7 ANK repeats.
genes like me logo Genes that share domains with PLA2G6: view

Function for PLA2G6 Gene

Molecular function for PLA2G6 Gene

GENATLAS Biochemistry:
phospholipase A2,Ca2+independent,group VI,expressed as oligomeric complex in bone,brain and other tissues,involved in the remodeling of membranes allowing arachidonic acid to be placed in the proper position in phospholipids for stimulated release
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by calcium-activated calmodulin.
UniProtKB/Swiss-Prot Function:
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.
UniProtKB/Swiss-Prot Function:
Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.

Enzyme Numbers (IUBMB) for PLA2G6 Gene

Gene Ontology (GO) - Molecular Function for PLA2G6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity TAS --
genes like me logo Genes that share ontologies with PLA2G6: view
genes like me logo Genes that share phenotypes with PLA2G6: view

Human Phenotype Ontology for PLA2G6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLA2G6 Gene

MGI Knock Outs for PLA2G6:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G6 Gene

Localization for PLA2G6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G6 Gene

Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.
Isoform SH-iPLA2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G6 Gene COMPARTMENTS Subcellular localization image for PLA2G6 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 4
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PLA2G6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PLA2G6: view

Pathways & Interactions for PLA2G6 Gene

genes like me logo Genes that share pathways with PLA2G6: view

Gene Ontology (GO) - Biological Process for PLA2G6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0007613 memory IEA --
GO:0008152 metabolic process IEA --
GO:0019731 antibacterial humoral response IDA 18714013
genes like me logo Genes that share ontologies with PLA2G6: view

No data available for SIGNOR curated interactions for PLA2G6 Gene

Drugs & Compounds for PLA2G6 Gene

(60) Drugs for PLA2G6 Gene - From: Novoseek, HMDB, ApexBio, Tocris, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Quinacrine Approved Pharma Target, inhibitor 6
Halobetasol Propionate Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
Stearic acid Experimental Pharma 0
arachidonic acid Experimental Nutra Activator 27

(105) Additional Compounds for PLA2G6 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
genes like me logo Genes that share compounds with PLA2G6: view

Drug Products

Transcripts for PLA2G6 Gene

Unigene Clusters for PLA2G6 Gene

Phospholipase A2, group VI (cytosolic, calcium-independent):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10 ^ 11a · 11b · 11c ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - - - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - - - - - - -
SP22: - - - - - -
SP23:
SP24: - - - - - - - - -
SP25:
SP26:
SP27:
SP28: - - - - -
SP29:

ExUns: 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c · 24d ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - -
SP5:
SP6: - - - - - -
SP7:
SP8: - -
SP9:
SP10: - - - - - - - - - - - - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: -
SP24:
SP25: - - -
SP26:
SP27:
SP28:
SP29:

ExUns: 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: -
SP27:
SP28:
SP29:

Relevant External Links for PLA2G6 Gene

GeneLoc Exon Structure for
PLA2G6
ECgene alternative splicing isoforms for
PLA2G6

Expression for PLA2G6 Gene

mRNA expression in normal human tissues for PLA2G6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLA2G6 Gene

This gene is overexpressed in Ovary (28.4), Frontal cortex (19.0), Retina (7.9), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLA2G6 Gene



SOURCE GeneReport for Unigene cluster for PLA2G6 Gene Hs.170479

mRNA Expression by UniProt/SwissProt for PLA2G6 Gene

O60733-PLPL9_HUMAN
Tissue specificity: Four different transcripts were found to be expressed in a distinct tissue distribution.
genes like me logo Genes that share expression patterns with PLA2G6: view

Protein tissue co-expression partners for PLA2G6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PLA2G6 Gene

Orthologs for PLA2G6 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G6 36
  • 100 (a)
OneToOne
PLA2G6 35
  • 99.55 (n)
  • 99.63 (a)
cow
(Bos Taurus)
Mammalia PLA2G6 36
  • 89 (a)
OneToOne
PLA2G6 35
  • 88.82 (n)
  • 88.82 (a)
dog
(Canis familiaris)
Mammalia PLA2G6 35
  • 89.87 (n)
  • 90.82 (a)
PLA2G6 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g6 36
  • 90 (a)
OneToOne
Pla2g6 16
Pla2g6 35
  • 87.06 (n)
  • 89.83 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA2G6 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G6 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g6 35
  • 86.48 (n)
  • 89.7 (a)
chicken
(Gallus gallus)
Aves PLA2G6 35
  • 69.7 (n)
  • 63.42 (a)
PLA2G6 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G6 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g6 35
  • 59.95 (n)
  • 52.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1493 35
zebrafish
(Danio rerio)
Actinopterygii pla2g6 35
  • 59.35 (n)
  • 55.58 (a)
pla2g6 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004812 35
  • 46.96 (n)
  • 38.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6718 37
  • 51 (a)
iPLA2-VIA 36
  • 32 (a)
OneToOne
iPLA2-VIA 35
  • 49.17 (n)
  • 39.5 (a)
worm
(Caenorhabditis elegans)
Secernentea D1037.5 36
  • 24 (a)
OneToMany
F47A4.5 36
  • 17 (a)
OneToMany
H23L24.2 36
  • 25 (a)
OneToMany
T04B2.5 36
  • 26 (a)
OneToMany
W07A8.2 36
  • 13 (a)
OneToMany
C45B2.6 37
  • 27 (a)
D1037.5 37
  • 30 (a)
F47A4.5 37
  • 27 (a)
H23L24.2 37
  • 28 (a)
F47A4.5 35
  • 42.09 (n)
  • 30.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for PLA2G6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G6 Gene

ENSEMBL:
Gene Tree for PLA2G6 (if available)
TreeFam:
Gene Tree for PLA2G6 (if available)

Paralogs for PLA2G6 Gene

Paralogs for PLA2G6 Gene

genes like me logo Genes that share paralogs with PLA2G6: view

Variants for PLA2G6 Gene

Sequence variations from dbSNP and Humsavar for PLA2G6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs11570605 - 38,169,255(-) ACTGC(A/G)TCCTG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs11570606 - 38,169,240(-) ACCCC(A/G)GGAAC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs11570607 - 38,169,218(-) ATTCC(A/G)GTGGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs11570646 - 38,143,167(-) TCACC(A/G)ACTAC nc-transcript-variant, reference, synonymous-codon, missense
rs11570680 - 38,132,881(-) CCAAC(A/G)CGGAT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLA2G6 Gene

Variant ID Type Subtype PubMed ID
nsv915035 CNV Loss 21882294
nsv834193 CNV Loss 17160897
dgv4968n71 CNV Loss 21882294
nsv471198 CNV Loss 18288195
dgv4969n71 CNV Loss 21882294
nsv834194 CNV Loss 17160897
nsv508732 CNV Insertion 20534489
nsv3623 CNV Insertion 18451855
esv996111 CNV Insertion 20482838
esv2724224 CNV Deletion 23290073
esv2661596 CNV Deletion 23128226
nsv519015 CNV Loss 19592680

Variation tolerance for PLA2G6 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G6 Gene

HapMap Linkage Disequilibrium report
PLA2G6
Human Gene Mutation Database (HGMD)
PLA2G6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G6 Gene

Disorders for PLA2G6 Gene

MalaCards: The human disease database

(18) MalaCards diseases for PLA2G6 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
parkinson disease 14, autosomal recessive
  • adult-onset dystonia-parkinsonism
infantile neuroaxonal dystrophy 1
  • neurodegeneration with brain iron accumulation 2b
neurodegeneration with brain iron accumulation 2b
  • karak syndrome
pla2g6-related parkinson disease
  • dystonia-parkinsonism, adult-onset
cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3
  • cemcox3
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PLPL9_HUMAN
  • Neurodegeneration with brain iron accumulation 2B (NBIA2B) [MIM:610217]: A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by progressive extrapyramidal dysfunction leading to rigidity, dystonia, dysarthria and sensorimotor impairment. {ECO:0000269 PubMed:16783378}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Neurodegeneration with brain iron accumulation 2A (NBIA2A) [MIM:256600]: A neurodegenerative disease characterized by pathologic axonal swelling and spheroid bodies in the central nervous system. Onset is within the first 2 years of life with death by age 10 years. {ECO:0000269 PubMed:16783378, ECO:0000269 PubMed:17033970, ECO:0000269 PubMed:23749988}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Parkinson disease 14 (PARK14) [MIM:612953]: An adult-onset progressive neurodegenerative disorder characterized by parkinsonism, dystonia, severe cognitive decline, cerebral and cerebellar atrophy and absent iron in the basal ganglia on magnetic resonance imaging. {ECO:0000269 PubMed:18570303}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PLA2G6

Genetic Association Database (GAD)
PLA2G6
Human Genome Epidemiology (HuGE) Navigator
PLA2G6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G6
genes like me logo Genes that share disorders with PLA2G6: view

No data available for Genatlas for PLA2G6 Gene

Publications for PLA2G6 Gene

  1. Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity. (PMID: 9417066) Larsson P.K.A. … Kennedy B.P. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Inhibition of phospholipase A2 attenuates functional hyperemia in the hamster cremaster muscle. (PMID: 10199854) Nuttle L.C. … Hester R.L. (Am. J. Physiol. 1999) 23 25 26
  3. Inhibition of calcium-independent phospholipase A2 activates p38 MAPK signaling pathways during cytostasis in prostate cancer cells. (PMID: 20171194) Sun B. … Cummings B.S. (Biochem. Pharmacol. 2010) 3 23
  4. Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. (PMID: 19059366) Rastogi P. … McHowat J. (Respir Physiol Neurobiol 2009) 3 23
  5. Two chromogranin a-derived peptides induce calcium entry in human neutrophils by calmodulin-regulated calcium independent phospholipase A2. (PMID: 19225567) Zhang D. … Metz-Boutigue M.H. (PLoS ONE 2009) 3 23

Products for PLA2G6 Gene

Sources for PLA2G6 Gene

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