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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLA2G5 Gene

protein-coding GIFtS: 66
GCID: GC01P020354

phospholipase A2, group V

Explore 13 diseases affiliated with
PLA2G5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase A2, Group V¹ ²		Ca2+-Dependent Phospholipase A2²
Phosphatidylcholine 2-Acylhydrolase 5² ³		Calcium-Dependent Phospholipase A2²
PLA2-10² ³		HVPLA(2)¹
FRFB²		EC 3.1.1.4³
GV-PLA2²		Group V Phospholipase A2³

External Ids:	HGNC: 9038¹	Entrez Gene: 5322²	Ensembl: ENSG00000127472⁷	OMIM: 601192⁵	UniProtKB: P39877³

Export aliases for PLA2G5 gene to outside databases

Previous GC identifers: GC01P019967 GC01P019431 GC01P019866 GC01P020142 GC01P020269 GC01P018642

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLA2G5:

This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory

phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to

generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes

linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory

responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length

nature has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877

Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme

hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl

phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl

phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac

muscle

summary for PLA2G5:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which

cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates

lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+

concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including

roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLA2G5 gene promoter:
AhR HNF-3beta RORalpha2 C/EBPalpha Evi-1 GATA-1 CHOP-10 HSF2 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLA2G5 promoter sequence

Search SABiosciences Chromatin IP Primers for PLA2G5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36-p34 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36-p34

PLA2G5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G5 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P020354: view genomic region (about GC identifiers)

Start:	20,354,672 bp from pter	End:	20,418,394 bp from pter
Size:	63,723 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877 (See protein sequence)

Recommended Name: Calcium-dependent phospholipase A2 precursor

Size: 138 amino acids; 15674 Da

Cofactor: Binds 1 calcium ion per subunit (By similarity)

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for PLA2G5:

2GHN (3D)

Secondary accessions: Q8N435

Explore the universe of human proteins at neXtProt for PLA2G5: NX_P39877

Post-translational modifications:

This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins¹

View neXtProt modification sites for NX_P39877

PLA2G5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000920.1

ENSEMBL proteins:

ENSP00000364249

Reactome Protein details: P39877
Human Recombinant Protein Products for PLA2G5:

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	Uscn Proteins for PLA2G5

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0009986	cell surface	IEA	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

PLA2G5 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PLA2G5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLA2G5 for domains About GeneDecksing

3 InterPro domains/families:

IPR016090 PLipase_A2

IPR001211 PLipase_A2_euk

IPR013090 PLipase_A2_AS

Graphical View of Domain Structure for InterPro Entry P39877

ProtoNet protein and cluster: P39877

1 Blocks protein family: IPB001211 Phospholipase A2

UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877

Similarity: Belongs to the phospholipase A2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PA2G5_HUMAN, P39877

Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme

hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl

phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl

phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac

muscle

Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate

Biophysicochemical properties: pH dependence: Optimum pH is 6.5. Activity remains high up to pH 9.0;

Genatlas biochemistry entry for PLA2G5:

phospholipase A2,group V,Ca2+ dependent,cytosolic,strongly expressed in heart

Enzyme Number (IUBMB): EC 3.1.1.4¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0008201	heparin binding	IEA	--
GO:0047498	calcium-dependent phospholipase A2 activity	IEA	--

PLA2G5 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PLA2G5:

Increased gamma-H2AX phosphory

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pla2g5):

cardiovascular system

cellular

homeostasis/metabolism

immune system

muscle

PLA2G5 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for PLA2G5: Pla2g5^tm1.1Kiku Pla2g5^tm1Jarm

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PLA2G5

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		hsa-miR-3176 hsa-miR-580 hsa-miR-590-3p hsa-miR-3922-3p
		SwitchGear 3'UTR luciferase reporter plasmid: PLA2G5 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Acyl chain remodelling of PE

8/9 pathways (see all 9)
Acyl chain remodelling of PE	1.00	phospholipases	0.39
Acyl chain remodelling of PC	0.85	Synthesis of PA	0.31
Acyl chain remodelling of PS	0.74	Anandamide biosynthesis and metabolism	0.13
Acyl chain remodelling of PI	0.62	Anandamide biosynthesis and metabolism	0.13

alpha-Linolenic acid metabolism

	alpha-Linolenic acid metabolism	1.00			Ether lipid metabolism	0.44
	Linoleic acid metabolism	0.52			Fat digestion and absorption	0.32

Glycerophospholipid biosynthesis

	Glycerophospholipid biosynthesis	1.00			Glycerophospholipid metabolism	0.54
	Phospholipid metabolism	0.64

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Immune response CD16 signaling in NK cells

Immune response CD16 signaling in NK cells

1.00

Immune response_CD16 signaling in NK cells

0.99

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for PLA2G5

	Immune response CD16 signaling in NK cells
	Anandamide biosynthesis and metabolism

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLA2G5 (see all 7)

	Chemokine Signaling
	DHA Signaling
	Antioxidant Action of Vitamin-C
	cAMP Pathway
	Phospholipase-C Pathway

2 GeneGo (Thomson Reuters) Pathways for PLA2G5

	Anandamide biosynthesis and metabolism
	Immune response CD16 signaling in NK cells

2 BioSystems Pathways for PLA2G5

	MAPK signaling pathway
	phospholipases

5/10 Reactome Pathways for PLA2G5 (see all 10)

	Acyl chain remodelling of PE
	Synthesis of PA
	Metabolism
	Acyl chain remodelling of PC
	Acyl chain remodelling of PG

5/16 Kegg Pathways (Kegg details for PLA2G5) (see all 16):

	Glycerophospholipid metabolism
	Ether lipid metabolism
	Arachidonic acid metabolism
	Linoleic acid metabolism
	alpha-Linolenic acid metabolism

PLA2G5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PLA2G5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for PLA2G5 (P39877³ ENSP00000364249⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLA2G4A	P47712³, ENSP00000356436⁴	I2D: score=1 STRING: ENSP00000356436
ALOX12	ENSP00000251535⁴	STRING: ENSP00000251535
ALOX12B	ENSP00000315167⁴	STRING: ENSP00000315167
ALOX15	ENSP00000293761⁴	STRING: ENSP00000293761
ALOX15B	ENSP00000369530⁴	STRING: ENSP00000369530

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006654	phosphatidic acid biosynthetic process	TAS	--
GO:0006663	platelet activating factor biosynthetic process	IEA	--
GO:0016042	lipid catabolic process	IEA	--
GO:0019370	leukotriene biosynthetic process	IEA	--

PLA2G5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PLA2G5 for compounds About GeneDecksing

EMD Millipore small molecules for PLA2G5:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLA2G5 available from Tocris Bioscience About this table

Compound	Action	CAS #
RHC 80267	Diacylglycerol lipase inhibitor	[83654-05-1]
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
OBAA	Phospholipase A2 inhibitor	[221632-26-4]
PACOCF3	Phospholipase A2 inhibitor	[141022-99-3]

10/2140 HMDB Compounds for PLA2G5 (see all 2140) About this table

Compound	Synonyms	CAS #	PubMed Ids
PC(O-16:0/18:2(9Z,12Z))	1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)	88542-95-4	12486725
PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)	--	12486725
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)	103597-60-0	12486725
Alpha-Linolenic acid	(9,12,15)-linolenate (see all 23)	463-40-1	--
Arachidic acid	Arachate (see all 10)	506-30-9	--
Arachidonic acid	5,8,11,14-Eicosatetraenoic acid (see all 16)	506-32-1	--
Calcium	Ca (see all 2)	7440-70-2	--
Heptadecanoic acid	Heptadecanoate (see all 16)	506-12-7	--
Heptadecanoyl CoA	Heptadecanoyl coenzyme A (see all 19)	3546-17-6	--
Linoleic acid	(9Z,12Z)-9,12-Octadecadienoate (see all 26)	60-33-3	--

2 Novoseek chemical compound relationships for PLA2G5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukotriene b4	59.8	1	12796497 (1)
phosphatidylcholine	58.6	1	10839997 (1)

Search CenterWatch for drugs/clinical trials and news about PLA2G5 / PA2G5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLA2G5 gene:

NM_000929.2

Unigene Cluster for PLA2G5:

Phospholipase A2, group V

Hs.319438 [show with all ESTs]

Unigene Representative Sequence: NM_000929

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000486277(uc001bcx.3) ENST00000465698 ENST00000460175 ENST00000469069

ENST00000489871 ENST00000498348 ENST00000375108(uc001bcy.3) ENST00000478803

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		GenScript: all cDNA clones in your preferred vector: PLA2G5 (NM_000929)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLA2G5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLA2G5

Additional cDNA sequence:

AK097693.1 BC036792.1 U03090.1

9 DOTS entries:

DT.210917 DT.91670033 DT.100019470 DT.100708852 DT.101981572 DT.101981573 DT.100813257 DT.121375427

DT.97838206

24/53 AceView cDNA sequences (see all 53):

AA293827 BX398027 AI418243 BU730619 BM710485 BC036792 AW132005 AI051138

BM663112 AI420062 AA526578 BU727090 CR607562 AI583184 BM931348 BE222806

NM_000929 U03090 CD013951 AV709457 BM685655 BM707860 BM716326 AJ711621

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G5 (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c
SP1:			-		-		-		-		-		-								-		-
SP2:			-		-		-		-		-		-										-
SP3:			-		-		-		-		-		-						-		-
SP4:											-
SP5:											-		-						-		-		-

ECgene alternative splicing isoforms for PLA2G5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLA2G5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAACCTCTG

About this image

PLA2G5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Liver

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PLA2G5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLA2G5

SOURCE GeneReport for Unigene cluster: Hs.319438

UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877

Tissue specificity: Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of

the retina (at protein level)

SABiosciences Expression via Pathway-Focused PCR Array including PLA2G5:

VEGF Signaling in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for PLA2G5 gene from 3/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLA2G5¹	phospholipase A2, group V	56.2(n) 46.72(a)		771655 XM_001234910.2 XP_001234911.1
fruit fly (Drosophila melanogaster)	Insecta	CG14507⁶	--	12(a)	possible ortholog	3R(25051926-25053447)
worm (Caenorhabditis elegans)	Secernentea	C07E3.9⁶ Y69A2AL.2⁶	--	24(a) 22(a)	possible ortholog possible ortholog	II(10350700-10351557) IV(2482256-2484111)

ENSEMBL Gene Tree for PLA2G5 (if available)
TreeFam Gene Tree for PLA2G5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PLA2G5 gene

ENSG00000258417² PLA2G2F² PLA2G2A² PLA2G2D² PLA2G1B² PLA2G2E² OC90² PLA2G10²

PLA2G2C²

7 SIMAP similar genes for PLA2G5 using alignment to 1 protein entry: PA2G5_HUMAN:

PLA2G2D PLA2G2A PLA2G2E PLA2G10 PLA2G2F PLA2G2C

PLA2G1B

PLA2G5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10916703^1,2	C,F,H	--	18641348(+)	`CATTCG/ATTGAA`	1	--	us2k¹		29	NS EA NA WA CSA	3314
rs11573189^1,2	C	--	18641976(+)	`TCCAGC/TCTGGG`	1	--	us2k¹		1	NS	164
rs113309521^1,2	C	--	18642125(+)	`TTCTGG/AATCGG`	1	--	us2k¹		1	NA	2
rs72661082^1,2	C,F	--	18642202(+)	`AGTTTT/CACTGT`	1	--	us2k¹		1	NA	120
rs11573192^1,2	C,F,H	--	18642388(+)	`CTAAAG/ACCGTG`	1	--	us2k¹ tfbs³		5	NS EA	596
rs668630^1,2	C,F,H	--	18642504(+)	`TCCTGC/ACTCTG`	1	--	us2k¹		26	EA NS NA WA CSA	4110
rs76363809^1,2	C,F	--	18642544(+)	`TACCCG/AGCTGG`	1	--	ut5¹		1	WA	118
rs2020885^1,2	C,F,H	--	18642652(+)	`TCCCCC/TCGGAT`	1	--	ut5¹ ese³		7	NA NS EA	682
rs117321541^1,2	C,F	--	18642732(+)	`GCCCAA/GGGAAG`	1	--	ut5¹		1	EA	120
rs2234959^1,2	C	--	18642781(+)	`CCAGGC/GAAAGA`	2	--	ut5¹		1	NA	84

HapMap Linkage Disequilibrium report for PLA2G5 (20354672 - 20418394 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for PLA2G5
9 CNVs: 48235 84111 63202 34760 74398 74396 97309 43756 84109
3 Indels: 84112 84110 74397
Human Gene Mutation Database (HGMD): PLA2G5

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLA2G5 for disorders About GeneDecksing

OMIM gene information: 601192 OMIM disorders: --

UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877

Defects in PLA2G5 are the cause of fleck retina, familial benign (FRFB) [MIM:228980]. An autosomal recessive

condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits.

Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white,

fleck-like lesions extending to the far periphery of the retina but sparing the foveal region

13 diseases for PLA2G5: About MalaCards

fundus albipunctatus esophageal squamous cell carcinoma squamous cell carcinoma spondylolisthesis

rheumatoid arthritis toxoplasmosis liver disease esophagitis

arthritis atherosclerosis carcinoma pancreatitis

neuronitis

1 disease from the University of Copenhagen DISEASES database for PLA2G5:

Fundus albipunctatus

Human Genome Epidemiology (HuGE) Navigator: PLA2G5 (6 documents)

Export disorders for PLA2G5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLA2G5 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with PLA2G5)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2. (PubMed id 8300559)^{1, 2, 3} Chen J.... Tischfield J.A. (1994)
Biallelic mutations in PLA2G5, encoding group V phosp holipase A2, cause benign fleck retina. (PubMed id 22137173)^{1, 2} Sergouniotis P.I....Webster A.R. (2011)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. (PubMed id 8838795)^{1, 3} Tischfield J.A....Lusis A.J. (1996)
Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. (PubMed id 17545304)^{1, 9} Wootton P.T....Talmud P.J. (2007)
Presence of secretory group IIa and V phospholipase A2 and cytosolic group IValpha phospholipase A2 in chondrocytes from patients with rheumatoid arthritis. (PubMed id 15259375)^{1, 9} Leistad L....Johansen B. (2004)
Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. (PubMed id 12796497)^{1, 9} Munoz N.M....Cho W. (2003)
Expression and characterization of human group V phospholipase A2. (PubMed id 9767110)^{1, 9} Chen Y. and Dennis E.A. (1998)
Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. (PubMed id 16785555)^{1, 9} Munoz N.M....Leff A.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5322	HGNC: 9038	AceView: PLA2G5	Ensembl:ENSG00000127472	euGenes: HUgn5322
ECgene: PLA2G5	Kegg: 5322	H-InvDB: PLA2G5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PLA2G5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PLA2G5	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/pla2g5/

Intellectual Property for PLA2G5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PLA2G5 gene:
Search GeneIP for patents involving PLA2G5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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PLA2G5 Gene

phospholipase A2, group V

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PLA2G5 Gene

phospholipase A2, group V

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