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PLA2G5 Gene

protein-coding   GIFtS: 68
GCID: GC01P020354

Phospholipase A2, Group V

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase A2, Group V1 2     Ca2+-Dependent Phospholipase A22
Phosphatidylcholine 2-Acylhydrolase 52 3     Calcium-Dependent Phospholipase A22
PLA2-102 3     hVPLA(2)2
FRFB2 5     EC 3.1.1.43
GV-PLA22     Group V Phospholipase A23

External Ids:    HGNC: 90381   Entrez Gene: 53222   Ensembl: ENSG000001274727   OMIM: 6011925   UniProtKB: P398773   

Export aliases for PLA2G5 gene to outside databases

Previous GC identifers: GC01P019967 GC01P019431 GC01P019866 GC01P020142 GC01P020269 GC01P018642


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLA2G5 Gene:
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of
secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane
phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially
hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce
inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their
full-length nature has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for PLA2G5 Gene:
PLA2G5 (phospholipase A2, group V) is a protein-coding gene. Diseases associated with PLA2G5 include fleck retina, familial benign, and spondylolisthesis. GO annotations related to this gene include calcium-dependent phospholipase A2 activity and calcium ion binding. An important paralog of this gene is ENSG00000258417.

UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This
isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than
L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl
phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the
production of lung surfactant, the remodeling or regulation of cardiac muscle

summary for PLA2G5 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLA2G5 gene promoter:
         AhR   HNF-3beta   RORalpha2   C/EBPalpha   Evi-1   GATA-1   CHOP-10   HSF2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2G5 promoter sequence
   Search Chromatin IP Primers for PLA2G5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLA2G5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36-p34   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36-p34

PLA2G5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P020354:  view genomic region     (about GC identifiers)

Start:
20,354,672 bp from pter      End:
20,418,394 bp from pter
Size:
63,723 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877 (See protein sequence)
Recommended Name: Calcium-dependent phospholipase A2 precursor  
Size: 138 amino acids; 15674 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
1 PDB 3D structure from and Proteopedia for PLA2G5:
2GHN (3D)    
Secondary accessions: Q8N435

Explore the universe of human proteins at neXtProt for PLA2G5: NX_P39877

Explore proteomics data for PLA2G5 at MOPED

Post-translational modifications: 

  • This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins1
  • Modification sites at neXtProt

  • See PLA2G5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000920.1  
    ENSEMBL proteins: 
     ENSP00000364249  
    Reactome Protein details: P39877

    PLA2G5 Human Recombinant Protein Products:

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    Novus Biologicals PLA2G5 Protein
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    ProSpec Recombinant Protein for PLA2G5
    Cloud-Clone Corp. Proteins for PLA2G5

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    Abcam antibodies for PLA2G5
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    Cloud-Clone Corp. ELISAs for PLA2G5
    Cloud-Clone Corp. CLIAs for PLA2G5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: PLA2-G5
    Phospholipase A2

    3 InterPro protein domains:
     IPR016090 PLipase_A2_dom
     IPR001211 PLipase_A2
     IPR013090 PLipase_A2_AS

    Graphical View of Domain Structure for InterPro Entry P39877

    ProtoNet protein and cluster: P39877

    1 Blocks protein domain: IPB001211 Phospholipase A2

    UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877
    Similarity: Belongs to the phospholipase A2 family


    PLA2G5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PA2G5_HUMAN, P39877
    Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This
    isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than
    L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl
    phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the
    production of lung surfactant, the remodeling or regulation of cardiac muscle
    Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
    Biophysicochemical properties: pH dependence: Optimum pH is 6.5. Activity remains high up to pH 9.0;

         Genatlas biochemistry entry for PLA2G5:
    phospholipase A2,group V,Ca2+ dependent,cytosolic,strongly expressed in heart

         Enzyme Number (IUBMB): EC 3.1.1.41

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0008201heparin binding IEA--
    GO:0047498calcium-dependent phospholipase A2 activity IEA--
         
    PLA2G5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PLA2G5:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pla2g5):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     muscle 

    PLA2G5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PLA2G5: Pla2g5tm1.1Kiku Pla2g5tm1Jarm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLA2G5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PLA2G5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLA2G5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLA2G5

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLA2G5:
    hsa-mir-128-3p (MIRT021933)

    Block miRNA regulation of human, mouse, rat PLA2G5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PLA2G5:
    hsa-miR-3176 hsa-miR-580 hsa-miR-590-3p hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLA2G5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLA2G5
    Predesigned siRNA for gene silencing in human, mouse, rat PLA2G5

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector: PLA2G5 (NM_000929)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G5

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    Browse ESI BIO Cell Lines and PureStem Progenitors for PLA2G5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PA2G5_HUMAN, P39877: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    PLA2G5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLA2G5 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Synthesis of PA0.33
    Phospholipid metabolism0.64
    Acyl chain remodelling of PG0.00
    Glycerophospholipid metabolism0.62
    Acyl chain remodelling of PI0.00
    2Acyl chain remodelling of PC
    Acyl chain remodelling of PE0.85
    Ether lipid metabolism0.48
    Acyl chain remodelling of PC0.85
    Acyl chain remodelling of PS0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Arachidonic acid metabolism
    Linoleic acid metabolism0.64
    Arachidonic acid metabolism0.41
    alpha-Linolenic acid metabolism0.64
    5Activation of cAMP-Dependent PKA
    cAMP Pathway0.77

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLA2G5 (see all 7)
        Chemokine Signaling
    DHA Signaling
    Antioxidant Action of Vitamin-C
    cAMP Pathway
    Phospholipase-C Pathway

    2 GeneGo (Thomson Reuters) Pathways for PLA2G5
        Anandamide biosynthesis and metabolism
    Immune response CD16 signaling in NK cells

    2 BioSystems Pathways for PLA2G5
        MAPK signaling pathway
    Spinal Cord Injury

    Selected Reactome Pathways for PLA2G5 (see all 6)
        Acyl chain remodelling of PE
    Acyl chain remodelling of PS
    Synthesis of PA
    Acyl chain remodelling of PC
    Acyl chain remodelling of PG


    Selected Kegg Pathways  (Kegg details for PLA2G5) (see all 10):
        Glycerophospholipid metabolism
    Ether lipid metabolism
    Arachidonic acid metabolism
    Linoleic acid metabolism
    alpha-Linolenic acid metabolism


    PLA2G5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PLA2G5: 
              VEGF Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLA2G5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLA2G5 (P398773 ENSP000003642494) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLA2G4AP477123, ENSP000003564364I2D: score=1 STRING: ENSP00000356436
    ALOX12ENSP000002515354STRING: ENSP00000251535
    ALOX12BENSP000003151674STRING: ENSP00000315167
    ALOX15ENSP000002937614STRING: ENSP00000293761
    ALOX15BENSP000003695304STRING: ENSP00000369530
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0006663platelet activating factor biosynthetic process IEA--
    GO:0016042lipid catabolic process IEA--
    GO:0019370leukotriene biosynthetic process IEA--

    PLA2G5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PLA2G5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLA2G5 (see all 2140)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    Alpha-Linolenic acid(9,12,15)-linolenate (see all 23)463-40-1--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    CalciumCa (see all 2)7440-70-2--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--

    2 Novoseek inferred chemical compound relationships for PLA2G5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukotriene b4 59.8 1 12796497 (1)
    phosphatidylcholine 58.6 1 10839997 (1)



    PLA2G5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PLA2G5 gene: 
    NM_000929.2  

    Unigene Cluster for PLA2G5:

    Phospholipase A2, group V
    Hs.319438  [show with all ESTs]
    Unigene Representative Sequence: NM_000929
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486277(uc001bcx.3) ENST00000465698 ENST00000460175 ENST00000469069
    ENST00000489871 ENST00000498348 ENST00000375108(uc001bcy.3) ENST00000478803

    miRNA
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    Block miRNA regulation of human, mouse, rat PLA2G5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PLA2G5:
    hsa-miR-3176 hsa-miR-580 hsa-miR-590-3p hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidPLA2G5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PLA2G5 (NM_000929)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G5
    Primer
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    OriGene qPCR primer pairs and template standards for PLA2G5
    OriGene qSTAR qPCR primer pairs in human, mouse for PLA2G5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLA2G5
      QuantiTect SYBR Green Assays in human, mouse, rat PLA2G5
      QuantiFast Probe-based Assays in human, mouse, rat PLA2G5

    Additional mRNA sequence: 

    AK097693.1 BC036792.1 U03090.1 

    9 DOTS entries:

    DT.210917  DT.91670033  DT.100019470  DT.100708852  DT.101981572  DT.101981573  DT.100813257  DT.121375427 
    DT.97838206 

    Selected AceView cDNA sequences (see all 53):

    AI420062 BC036792 AA526578 BX398027 AW132005 AI051138 BU727090 AI418243 
    BM663112 CR607562 BU730619 AA293827 BM710485 CD013951 AA402475 BX378185 
    BX093951 AI769155 BX389673 BX345779 CD013950 AI468128 NM_000929 AA973633 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G5 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:        -     -     -     -     -     -                       -     -                           
    SP2:        -     -     -     -     -     -                             -                           
    SP3:        -     -     -     -     -     -                 -     -                                 
    SP4:                                -                                                               
    SP5:                                -     -                 -     -     -                           


    ECgene alternative splicing isoforms for PLA2G5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PLA2G5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACCTCTG
    PLA2G5 Expression
    About this image


    PLA2G5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Hepatocyte-like cells
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    PLA2G5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLA2G5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.319438

    UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877
    Tissue specificity: Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers
    of the retina (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including PLA2G5: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PLA2G5 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2g51 , 5 phospholipase A2, group V1, 5 79.08(n)1
    78.1(a)1
      4 (70.57 cM)5
    187841  NM_001122954.11  NP_001116426.11 
     1387992445 
    chicken
    (Gallus gallus)
    Aves PLA2G51 phospholipase A2, group V 55.96(n)
    45.99(a)
      771655  NM_001278044.1  NP_001264973.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    42(a)
    1 → many
    AAWZ02041529(3693-5527)


    ENSEMBL Gene Tree for PLA2G5 (if available)
    TreeFam Gene Tree for PLA2G5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLA2G5 gene
    ENSG000002584172  PLA2G2F2  PLA2G2E2  PLA2G2A2  PLA2G1B2  PLA2G2D2  OC902  PLA2G102  
    PLA2G2C2  
    7 SIMAP similar genes for PLA2G5 using alignment to 1 protein entry:     PA2G5_HUMAN:
    PLA2G2D    PLA2G2A    PLA2G2E    PLA2G10    PLA2G2F    PLA2G2C
    PLA2G1B

    PLA2G5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLA2G5 (see all 559)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0673434
    Fleck retina, familial benign (FRFB)4--see VAR_0673432 G C mis40--------
    VAR_0673444
    Fleck retina, familial benign (FRFB)4--see VAR_0673442 G S mis40--------
    rs115732991,2
    F--18664715(+) AGACTGT/-CCAAA 1 -- ds50011Minor allele frequency- -:0.02NS 174
    rs57728811,2
    C,F--20395760(+) CTTACA/-AAAAA 1 -- us2k11Minor allele frequency- -:0.13NS 170
    rs115732111,2
    C--20401764(+) ACCCCC/-AAGGG 1 -- int12Minor allele frequency- -:0.01NS NA 180
    rs115732211,2
    C,F--20403078(+) TGCCCCT/-CTGTT 1 -- int11Minor allele frequency- -:0.34NS 176
    rs115732301,2
    C--20404614(+) GAGAGAGAG/-  
            
    TTTCG
    1 -- int11Minor allele frequency- -:0.01NS 166
    rs115732311,2
    C--20404817(+) AAAAA-/AGAAGT 1 -- int1 trp31Minor allele frequency- A:0.01NS 170
    rs115732331,2
    C,F--20405425(+) TGGGAC/-CCCGA 1 -- int11Minor allele frequency- -:0.07NS 180
    rs57728821,2
    C,F--20405607(+) aaaaaA/-aaaaa 1 -- int1 trp32Minor allele frequency- -:0.50NA 4

    HapMap Linkage Disequilibrium report for PLA2G5 (20354672 - 20418394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PLA2G5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2164449CNV Deletion18987734
    esv2435763CNV Deletion19546169
    esv2665474CNV Deletion23128226
    nsv519515CNV Loss19592680
    esv25446CNV Loss19812545
    nsv5520CNV Loss18451855

    Human Gene Mutation Database (HGMD): PLA2G5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLA2G5
    DNA2.0 Custom Variant and Variant Library Synthesis for PLA2G5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601192   
    OMIM disorders: 228980  
    UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877
  • Fleck retina, familial benign (FRFB) [MIM:228980]: An autosomal recessive condition associated with a
    distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are
    asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions
    extending to the far periphery of the retina but sparing the foveal region. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for PLA2G5 (see all 21):    
    About MalaCards
    fleck retina, familial benign    spondylolisthesis    fundus albipunctatus    toxoplasmosis
    esophageal squamous cell carcinoma    spinal cord injury    liver disease    choroiditis
    esophagitis    atherosclerosis    squamous cell carcinoma    rheumatoid arthritis
    arthritis    retinitis    endotheliitis    hiv-1
    multiple myeloma    myeloma    pancreatitis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for PLA2G5:
    Fundus albipunctatus

    PLA2G5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLA2G5
    Human Genome Epidemiology (HuGE) Navigator: PLA2G5 (6 documents)

    Export disorders for PLA2G5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLA2G5 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with PLA2G5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2. (PubMed id 8300559)1, 2, 3 Chen J.... Tischfield J.A. (J. Biol. Chem. 1994)
    2. Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. (PubMed id 17545304)1, 4, 9 Wootton P.T....Talmud P.J. (Hum. Mol. Genet. 2007)
    3. Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina. (PubMed id 22137173)1, 2 Sergouniotis P.I.... Webster A.R. (Am. J. Hum. Genet. 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. (PubMed id 8838795)1, 3 Tischfield J.A....Lusis A.J. (Genomics 1996)
    8. Presence of secretory group IIa and V phospholipase A2 and cytosolic group IValpha phospholipase A2 in chondrocytes from patients with rheumatoid arthritis. (PubMed id 15259375)1, 9 Leistad L....Johansen B. (Clin. Chem. Lab. Med. 2004)
    9. Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. (PubMed id 12796497)1, 9 MuA+oz N.M....Cho W. (J. Biol. Chem. 2003)
    10. Expression and characterization of human group V phospholipase A2. (PubMed id 9767110)1, 9 Chen Y. and Dennis E.A. (Biochim. Biophys. Acta 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5322 HGNC: 9038 AceView: PLA2G5 Ensembl:ENSG00000127472 euGenes: HUgn5322
    ECgene: PLA2G5 Kegg: 5322 H-InvDB: PLA2G5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLA2G5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLA2G5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/pla2g5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLA2G5 gene:
    Search GeneIP for patents involving PLA2G5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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