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Aliases for PLA2G5 Gene

Aliases for PLA2G5 Gene

  • Phospholipase A2 Group V 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 5 3 4
  • PLA2-10 3 4
  • Calcium-Dependent Phospholipase A2 3
  • Ca2+-Dependent Phospholipase A2 3
  • Phospholipase A2, Group V 2
  • Group V Phospholipase A2 4
  • EC 3.1.1.4 4
  • HVPLA(2) 3
  • GV-PLA2 3
  • FRFB 3

External Ids for PLA2G5 Gene

Previous GeneCards Identifiers for PLA2G5 Gene

  • GC01P019967
  • GC01P019431
  • GC01P019866
  • GC01P020142
  • GC01P020269
  • GC01P020354
  • GC01P018642

Summaries for PLA2G5 Gene

Entrez Gene Summary for PLA2G5 Gene

  • This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLA2G5 Gene

PLA2G5 (Phospholipase A2 Group V) is a Protein Coding gene. Diseases associated with PLA2G5 include Fleck Retina, Familial Benign. Among its related pathways are Metabolism and Acyl chain remodelling of PE. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PLA2G2A.

UniProtKB/Swiss-Prot for PLA2G5 Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.

Tocris Summary for PLA2G5 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G5 Gene

Genomics for PLA2G5 Gene

Regulatory Elements for PLA2G5 Gene

Enhancers for PLA2G5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F020077 0.9 Ensembl ENCODE 14.6 +50.2 50151 0.9 HDGF RFX1 TBL1XR1 TRIM22 EBF1 EP300 RELA IKZF1 NBN PRDM10 PLA2G5 LOC100419911 PLA2G2D
GH01F020080 1.2 FANTOM5 Ensembl ENCODE 8.9 +52.8 52776 1.5 ZNF146 TBL1XR1 MTA2 NR2F2 EED IKZF1 TARDBP NBN ZNF580 MLLT1 PLA2G5 UBXN10 HTR6 NBL1 PLA2G2D LOC100419911
GH01F020058 0.9 Ensembl ENCODE 11.7 +31.4 31422 3.2 RFX1 MTA2 BMI1 TBX21 ZNF623 GABPA NR2F2 EED IKZF1 ZNF24 PLA2G5 PLA2G2C LOC100419911 PLA2G2D
GH01F020032 0.9 FANTOM5 9.3 +4.4 4367 0.4 TFAP4 KLF1 SAP130 FEZF1 ZNF2 RAD21 RARA ZNF335 GATA3 ZNF600 PLA2G5 PLA2G2A LOC100419911
GH01F020008 1.1 FANTOM5 ENCODE 6.7 -19.4 -19438 1.3 HDAC1 PKNOX1 ESRRA ATF1 TBL1XR1 TAL1 BMI1 ZNF384 ZBTB40 ZNF316 PLA2G5 UBXN10 PIR59989
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLA2G5 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G5 Gene

Chromosome:
1
Start:
20,028,179 bp from pter
End:
20,091,901 bp from pter
Size:
63,723 bases
Orientation:
Plus strand

Genomic View for PLA2G5 Gene

Genes around PLA2G5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G5 Gene

Proteins for PLA2G5 Gene

  • Protein details for PLA2G5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39877-PA2G5_HUMAN
    Recommended name:
    Calcium-dependent phospholipase A2
    Protein Accession:
    P39877
    Secondary Accessions:
    • Q8N435

    Protein attributes for PLA2G5 Gene

    Size:
    138 amino acids
    Molecular mass:
    15674 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLA2G5 Gene

neXtProt entry for PLA2G5 Gene

Post-translational modifications for PLA2G5 Gene

  • This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.

No data available for DME Specific Peptides for PLA2G5 Gene

Domains & Families for PLA2G5 Gene

Gene Families for PLA2G5 Gene

Protein Domains for PLA2G5 Gene

Suggested Antigen Peptide Sequences for PLA2G5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P39877

UniProtKB/Swiss-Prot:

PA2G5_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G5: view

Function for PLA2G5 Gene

Molecular function for PLA2G5 Gene

GENATLAS Biochemistry:
phospholipase A2,group V,Ca2+ dependent,cytosolic,strongly expressed in heart
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.5. Activity remains high up to pH 9.0.;
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.

Enzyme Numbers (IUBMB) for PLA2G5 Gene

Gene Ontology (GO) - Molecular Function for PLA2G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0008201 heparin binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G5: view
genes like me logo Genes that share phenotypes with PLA2G5: view

Human Phenotype Ontology for PLA2G5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLA2G5 Gene

MGI Knock Outs for PLA2G5:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PLA2G5 Gene

Localization for PLA2G5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G5 gene
Compartment Confidence
extracellular 5
plasma membrane 3
golgi apparatus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for PLA2G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PLA2G5: view

Pathways & Interactions for PLA2G5 Gene

genes like me logo Genes that share pathways with PLA2G5: view

Gene Ontology (GO) - Biological Process for PLA2G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 8300559
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006663 platelet activating factor biosynthetic process IEA --
GO:0010518 positive regulation of phospholipase activity IDA 22837859
genes like me logo Genes that share ontologies with PLA2G5: view

No data available for SIGNOR curated interactions for PLA2G5 Gene

Drugs & Compounds for PLA2G5 Gene

(15) Drugs for PLA2G5 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0

(46) Additional Compounds for PLA2G5 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G5 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
U 73343 Analog of U 73122 (Cat. No. 1268) 142878-12-4
VU 0155069 Potent and selective PLD1 inhibitor 1130067-06-9
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor 1244640-48-9

(3) ApexBio Compounds for PLA2G5 Gene

Compound Action Cas Number
Anti-Inflammatory Peptide 1 PLA2 inhibitor 118850-71-8
D609 PC-PLC inhibitor 83373-60-8
Halobetasol Propionate 66852-54-8
genes like me logo Genes that share compounds with PLA2G5: view

Transcripts for PLA2G5 Gene

Unigene Clusters for PLA2G5 Gene

Phospholipase A2, group V:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: -
SP9: - - - - - - - - -
SP10: - - - - - -

Relevant External Links for PLA2G5 Gene

GeneLoc Exon Structure for
PLA2G5
ECgene alternative splicing isoforms for
PLA2G5

Expression for PLA2G5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G5 Gene

This gene is overexpressed in Heart - Atrial Appendage (x12.2), Ovary (x7.0), Heart - Left Ventricle (x7.0), and Artery - Coronary (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of PLA2G5 Gene:

PLA2G5

SOURCE GeneReport for Unigene cluster for PLA2G5 Gene:

Hs.319438

mRNA Expression by UniProt/SwissProt for PLA2G5 Gene:

P39877-PA2G5_HUMAN
Tissue specificity: Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level).
genes like me logo Genes that share expression patterns with PLA2G5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PLA2G5 Gene

Orthologs for PLA2G5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G5 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia PLA2G5 34 35
  • 86.96 (n)
rat
(Rattus norvegicus)
Mammalia Pla2g5 34
  • 79.32 (n)
cow
(Bos Taurus)
Mammalia PLA2G5 34 35
  • 79.23 (n)
mouse
(Mus musculus)
Mammalia Pla2g5 34 16 35
  • 79.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G5 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 49 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves PLA2G5 34 35
  • 55.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
OneToMany
Species where no ortholog for PLA2G5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G5 Gene

ENSEMBL:
Gene Tree for PLA2G5 (if available)
TreeFam:
Gene Tree for PLA2G5 (if available)

Paralogs for PLA2G5 Gene

(7) SIMAP similar genes for PLA2G5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLA2G5: view

Variants for PLA2G5 Gene

Sequence variations from dbSNP and Humsavar for PLA2G5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs387906795 Fleck retina, familial benign (FRFB) [MIM:228980], other 20,086,175(+) TCTAC(A/G/T)GCTGT reference, missense
rs387906796 Fleck retina, familial benign (FRFB) [MIM:228980], other 20,086,187(+) ACTGC(A/G)GCTGG reference, missense
rs200954922 other 20,086,199(+) GCGGC(C/T)GAGGA reference, stop-gained
rs10799606 -- 20,032,693(+) tggaa(C/T)ttggg intron-variant
rs10799607 -- 20,050,101(+) attaa(G/T)ttttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G5 Gene

Variant ID Type Subtype PubMed ID
nsv5520 CNV deletion 18451855
nsv545731 CNV gain 21841781
nsv519515 CNV loss 19592680
nsv1003802 CNV loss 25217958
esv3585413 CNV loss 21293372
esv2665474 CNV deletion 23128226
esv25446 CNV loss 19812545
esv2435763 CNV deletion 19546169
esv2164449 CNV deletion 18987734

Variation tolerance for PLA2G5 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G5 Gene

Human Gene Mutation Database (HGMD)
PLA2G5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G5 Gene

Disorders for PLA2G5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLA2G5 Gene - From: GeneTests, Orphanet, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
fleck retina, familial benign
  • frfb
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PA2G5_HUMAN
  • Fleck retina, familial benign (FRFB) [MIM:228980]: An autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region. {ECO:0000269 PubMed:22137173}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PLA2G5

Genetic Association Database (GAD)
PLA2G5
Human Genome Epidemiology (HuGE) Navigator
PLA2G5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G5
genes like me logo Genes that share disorders with PLA2G5: view

No data available for Genatlas for PLA2G5 Gene

Publications for PLA2G5 Gene

  1. Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. (PMID: 17545304) Wootton P.T. … Talmud P.J. (Hum. Mol. Genet. 2007) 3 22 46 64
  2. Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2. (PMID: 8300559) Chen J. … Tischfield J.A. (J. Biol. Chem. 1994) 2 3 4 64
  3. Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina. (PMID: 22137173) Sergouniotis P.I. … Webster A.R. (Am. J. Hum. Genet. 2011) 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for PLA2G5 Gene

Sources for PLA2G5 Gene

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