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Aliases for PLA2G4F Gene

Aliases for PLA2G4F Gene

  • Phospholipase A2 Group IVF 2 3 4 5
  • Phospholipase A2, Group IVF 2 3
  • CPLA2-Zeta 3 4
  • EC 3.1.1.4 4
  • PLA2G4FZ 3

External Ids for PLA2G4F Gene

Previous GeneCards Identifiers for PLA2G4F Gene

  • GC15M040221
  • GC15M042433
  • GC15M019282

Summaries for PLA2G4F Gene

GeneCards Summary for PLA2G4F Gene

PLA2G4F (Phospholipase A2 Group IVF) is a Protein Coding gene. Among its related pathways are Linoleic acid metabolism and Phospholipase D signaling pathway. GO annotations related to this gene include phospholipase A2 activity and lysophospholipase activity. An important paralog of this gene is JMJD7-PLA2G4B.

UniProtKB/Swiss-Prot for PLA2G4F Gene

  • Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).

Tocris Summary for PLA2G4F Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4F Gene

Genomics for PLA2G4F Gene

Regulatory Elements for PLA2G4F Gene

Enhancers for PLA2G4F Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLA2G4F on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G4F Gene

Chromosome:
15
Start:
42,139,034 bp from pter
End:
42,156,641 bp from pter
Size:
17,608 bases
Orientation:
Minus strand

Genomic View for PLA2G4F Gene

Genes around PLA2G4F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G4F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G4F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4F Gene

Proteins for PLA2G4F Gene

  • Protein details for PLA2G4F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DD2-PA24F_HUMAN
    Recommended name:
    Cytosolic phospholipase A2 zeta
    Protein Accession:
    Q68DD2
    Secondary Accessions:
    • Q6ZMC8

    Protein attributes for PLA2G4F Gene

    Size:
    849 amino acids
    Molecular mass:
    95082 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G4F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G4F Gene

Proteomics data for PLA2G4F Gene at MOPED

Post-translational modifications for PLA2G4F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G4F Gene

No data available for DME Specific Peptides for PLA2G4F Gene

Domains & Families for PLA2G4F Gene

Protein Domains for PLA2G4F Gene

Graphical View of Domain Structure for InterPro Entry

Q68DD2

UniProtKB/Swiss-Prot:

PA24F_HUMAN :
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Domain:
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
  • Contains 1 C2 domain.
  • Contains 1 PLA2c domain.
genes like me logo Genes that share domains with PLA2G4F: view

Function for PLA2G4F Gene

Molecular function for PLA2G4F Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by cytosolic Ca(2+).
UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).

Enzyme Numbers (IUBMB) for PLA2G4F Gene

Gene Ontology (GO) - Molecular Function for PLA2G4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008970 phosphatidylcholine 1-acylhydrolase activity TAS --
GO:0047498 calcium-dependent phospholipase A2 activity IEA --
genes like me logo Genes that share ontologies with PLA2G4F: view
genes like me logo Genes that share phenotypes with PLA2G4F: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G4F Gene

Localization for PLA2G4F Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4F Gene

Cytoplasm, cytosol. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to lysosomal membranes in a calcium-dependent fashion. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G4F Gene COMPARTMENTS Subcellular localization image for PLA2G4F gene
Compartment Confidence
cytosol 5
lysosome 4
vacuole 4
plasma membrane 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PLA2G4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PLA2G4F: view

Pathways & Interactions for PLA2G4F Gene

genes like me logo Genes that share pathways with PLA2G4F: view

Interacting Proteins for PLA2G4F Gene

Selected Interacting proteins: Q68DD2-PA24F_HUMAN for PLA2G4F Gene via I2D

Symbol External ID(s) Details
ALB

Gene Ontology (GO) - Biological Process for PLA2G4F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IEA --
GO:0015908 fatty acid transport IEA --
GO:0036149 phosphatidylinositol acyl-chain remodeling TAS --
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with PLA2G4F: view

No data available for SIGNOR curated interactions for PLA2G4F Gene

Drugs & Compounds for PLA2G4F Gene

(9) Drugs for PLA2G4F Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(12) Additional Compounds for PLA2G4F Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate
1002-84-2

(5) Tocris Compounds for PLA2G4F Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G4F: view

Transcripts for PLA2G4F Gene

Unigene Clusters for PLA2G4F Gene

Phospholipase A2, group IVF:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4F Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3:
SP4: -

Relevant External Links for PLA2G4F Gene

GeneLoc Exon Structure for
PLA2G4F
ECgene alternative splicing isoforms for
PLA2G4F

Expression for PLA2G4F Gene

mRNA expression in normal human tissues for PLA2G4F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4F Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.4) and Skin - Sun Exposed (Lower leg) (x13.6).

Protein differential expression in normal tissues from HIPED for PLA2G4F Gene

This gene is overexpressed in Kidney (29.3), Brain (22.0), and Stomach (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4F Gene



SOURCE GeneReport for Unigene cluster for PLA2G4F Gene Hs.231873

genes like me logo Genes that share expression patterns with PLA2G4F: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PLA2G4F Gene

Orthologs for PLA2G4F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLA2G4F Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2G4F 35
  • 84.85 (n)
  • 82.72 (a)
PLA2G4F 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G4F 35
  • 85.87 (n)
  • 84.77 (a)
PLA2G4F 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g4f 35
  • 79.87 (n)
  • 74 (a)
Pla2g4f 16
Pla2g4f 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G4F 35
  • 98.94 (n)
  • 98.47 (a)
PLA2G4F 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g4f 35
  • 79.23 (n)
  • 73.5 (a)
chicken
(Gallus gallus)
Aves PLA2G4F 35
  • 61.16 (n)
  • 57.23 (a)
lizard
(Anolis carolinensis)
Reptilia PLA2G4F 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g4f 35
  • 58.79 (n)
  • 55.16 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC798864 35
  • 50.54 (n)
  • 41.21 (a)
PLA2G4F (1 of 2) 36
  • 38 (a)
OneToMany
PLA2G4F (2 of 2) 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLB1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for PLA2G4F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G4F Gene

ENSEMBL:
Gene Tree for PLA2G4F (if available)
TreeFam:
Gene Tree for PLA2G4F (if available)

Paralogs for PLA2G4F Gene

Paralogs for PLA2G4F Gene

genes like me logo Genes that share paralogs with PLA2G4F: view

Variants for PLA2G4F Gene

Sequence variations from dbSNP and Humsavar for PLA2G4F Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1356410 - 42,142,639(-) AGGAC(A/G)TGGAG nc-transcript-variant, reference, missense
rs636604 - 42,156,461(-) GAGGG(G/T)CCCTC nc-transcript-variant, reference, missense
rs5812214 -- 42,155,102(+) ACACA(-/TACA)CACTC intron-variant
rs593910 -- 42,155,745(-) CTCCC(A/T)ATGCC intron-variant
rs595661 -- 42,155,367(-) tgagt(A/G)tacgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4F Gene

Variant ID Type Subtype PubMed ID
nsv471683 CNV Gain+Loss 15918152
nsv832985 CNV Loss 17160897
esv2749622 CNV Deletion 23290073
esv2664756 CNV Deletion 23128226
nsv442371 CNV CNV 18776908
nsv9245 CNV Gain 18304495

Variation tolerance for PLA2G4F Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.37; 76.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G4F Gene

HapMap Linkage Disequilibrium report
PLA2G4F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4F Gene

Disorders for PLA2G4F Gene

Relevant External Links for PLA2G4F

Genetic Association Database (GAD)
PLA2G4F
Human Genome Epidemiology (HuGE) Navigator
PLA2G4F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G4F

No disorders were found for PLA2G4F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G4F Gene

Publications for PLA2G4F Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. (PMID: 15866882) Ohto T. … Shimizu T. (J. Biol. Chem. 2005) 2 3
  3. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for PLA2G4F Gene

Sources for PLA2G4F Gene

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