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Aliases for PLA2G4C Gene

Aliases for PLA2G4C Gene

  • Phospholipase A2 Group IVC 2 3 4 5
  • Phospholipase A2, Group IVC (Cytosolic, Calcium-Independent) 2 3
  • CPLA2-Gamma 3 4
  • EC 3.1.1.4 4

External Ids for PLA2G4C Gene

Previous GeneCards Identifiers for PLA2G4C Gene

  • GC19M049195
  • GC19M048919
  • GC19M053227
  • GC19M053242
  • GC19M048551
  • GC19M044932

Summaries for PLA2G4C Gene

Entrez Gene Summary for PLA2G4C Gene

  • This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for PLA2G4C Gene

PLA2G4C (Phospholipase A2 Group IVC) is a Protein Coding gene. Diseases associated with PLA2G4C include Fibrillary Astrocytoma. Among its related pathways are Platelet activation and Linoleic acid metabolism. GO annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is JMJD7-PLA2G4B.

UniProtKB/Swiss-Prot for PLA2G4C Gene

  • Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.

Tocris Summary for PLA2G4C Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G4C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4C Gene

Genomics for PLA2G4C Gene

Regulatory Elements for PLA2G4C Gene

Enhancers for PLA2G4C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLA2G4C on UCSC Golden Path with GeneCards custom track

Promoters for PLA2G4C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLA2G4C on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G4C Gene

Chromosome:
19
Start:
48,047,843 bp from pter
End:
48,110,853 bp from pter
Size:
63,011 bases
Orientation:
Minus strand

Genomic View for PLA2G4C Gene

Genes around PLA2G4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4C Gene

Proteins for PLA2G4C Gene

  • Protein details for PLA2G4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UP65-PA24C_HUMAN
    Recommended name:
    Cytosolic phospholipase A2 gamma
    Protein Accession:
    Q9UP65
    Secondary Accessions:
    • B2RB71
    • B4DI40
    • O75457
    • Q6IBI8
    • Q9UG68

    Protein attributes for PLA2G4C Gene

    Size:
    541 amino acids
    Molecular mass:
    60939 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G4C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G4C Gene

Proteomics data for PLA2G4C Gene at MOPED

Post-translational modifications for PLA2G4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLA2G4C Gene

Domains & Families for PLA2G4C Gene

Gene Families for PLA2G4C Gene

Protein Domains for PLA2G4C Gene

Graphical View of Domain Structure for InterPro Entry

Q9UP65

UniProtKB/Swiss-Prot:

PA24C_HUMAN :
  • Contains 1 PLA2c domain.
Domain:
  • Contains 1 PLA2c domain.
genes like me logo Genes that share domains with PLA2G4C: view

Function for PLA2G4C Gene

Molecular function for PLA2G4C Gene

GENATLAS Biochemistry:
phospholipase A2,group IVB,Ca2+ independent,cytosolic,ubiquitously predominantly expressed in cardiac and skeletal muscle paralog of PLA2G2A
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=218 pmol/min/mg enzyme {ECO:0000269 PubMed:10085124};
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Not regulated by calcium.
UniProtKB/Swiss-Prot Function:
Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.

Enzyme Numbers (IUBMB) for PLA2G4C Gene

genes like me logo Genes that share phenotypes with PLA2G4C: view

Animal Model Products

miRNA for PLA2G4C Gene

miRTarBase miRNAs that target PLA2G4C

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G4C Gene

Localization for PLA2G4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4C Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G4C Gene COMPARTMENTS Subcellular localization image for PLA2G4C gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PLA2G4C Gene

Pathways & Interactions for PLA2G4C Gene

genes like me logo Genes that share pathways with PLA2G4C: view

Interacting Proteins for PLA2G4C Gene

Selected Interacting proteins: Q9UP65-PA24C_HUMAN for PLA2G4C Gene via I2D

Symbol External ID(s) Details
S100A10

Gene Ontology (GO) - Biological Process for PLA2G4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036149 phosphatidylinositol acyl-chain remodeling TAS --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046474 glycerophospholipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with PLA2G4C: view

No data available for SIGNOR curated interactions for PLA2G4C Gene

Drugs & Compounds for PLA2G4C Gene

(9) Drugs for PLA2G4C Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
arachidonic acid Experimental Nutra Activator 27
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0

(15) Additional Compounds for PLA2G4C Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate
1002-84-2

(5) Tocris Compounds for PLA2G4C Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G4C: view

Transcripts for PLA2G4C Gene

Unigene Clusters for PLA2G4C Gene

Phospholipase A2, group IVC (cytosolic, calcium-independent):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4C Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - - - -
SP7:
SP8: - - - - - - - - -
SP9: - -
SP10: - - - -
SP11: - -
SP12: - - - - - - - - - - -
SP13:
SP14:

ExUns: 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PLA2G4C Gene

GeneLoc Exon Structure for
PLA2G4C
ECgene alternative splicing isoforms for
PLA2G4C

Expression for PLA2G4C Gene

mRNA expression in normal human tissues for PLA2G4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4C Gene

This gene is overexpressed in Muscle - Skeletal (x5.4).

Protein differential expression in normal tissues from HIPED for PLA2G4C Gene

This gene is overexpressed in Serum (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4C Gene



SOURCE GeneReport for Unigene cluster for PLA2G4C Gene Hs.631562

mRNA Expression by UniProt/SwissProt for PLA2G4C Gene

Q9UP65-PA24C_HUMAN
Tissue specificity: Highly expressed in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with PLA2G4C: view

Protein tissue co-expression partners for PLA2G4C Gene

Primer Products

Orthologs for PLA2G4C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G4C Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Pla2g4c 35
  • 68.7 (n)
  • 59.81 (a)
Pla2g4c 16
Pla2g4c 36
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G4C 35
  • 98.99 (n)
  • 98.49 (a)
PLA2G4C 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:101699 35
  • 48.64 (n)
  • 38.7 (a)
PLA2G4C (1 of 5) 36
  • 27 (a)
OneToMany
PLA2G4C (2 of 5) 36
  • 27 (a)
OneToMany
PLA2G4C (3 of 5) 36
  • 29 (a)
OneToMany
PLA2G4C (4 of 5) 36
  • 27 (a)
OneToMany
PLA2G4C (5 of 5) 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
Species with no ortholog for PLA2G4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G4C Gene

ENSEMBL:
Gene Tree for PLA2G4C (if available)
TreeFam:
Gene Tree for PLA2G4C (if available)

Paralogs for PLA2G4C Gene

Paralogs for PLA2G4C Gene

genes like me logo Genes that share paralogs with PLA2G4C: view

Variants for PLA2G4C Gene

Sequence variations from dbSNP and Humsavar for PLA2G4C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2307279 - 48,105,341(-) TTGAG(C/G)CTGAT reference, missense
rs2303744 - 48,099,691(-) TGGTT(A/G)TCTCT upstream-variant-2KB, reference, missense
rs156631 - 48,095,566(-) GCTTC(C/T)CTGCA reference, missense
rs191276960 - 48,055,019(+) GTGGC(A/G)GCGGC reference, missense
rs11564522 - 48,105,392(-) CCGTG(A/G)AGAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4C Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833853 CNV Loss 17160897
nsv912216 CNV Loss 21882294
esv34181 CNV Loss 18971310
nsv2516 CNV Insertion 18451855
esv2666003 CNV Deletion 23128226
nsv2517 CNV Insertion 18451855

Variation tolerance for PLA2G4C Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.09; 90.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G4C Gene

Human Gene Mutation Database (HGMD)
PLA2G4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4C Gene

Disorders for PLA2G4C Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLA2G4C Gene - From: DISEASES

Disorder Aliases PubMed IDs
fibrillary astrocytoma
  • diffuse astrocytoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2G4C

Genetic Association Database (GAD)
PLA2G4C
Human Genome Epidemiology (HuGE) Navigator
PLA2G4C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G4C
genes like me logo Genes that share disorders with PLA2G4C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G4C Gene

Publications for PLA2G4C Gene

  1. A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2. (PMID: 9705332) Underwood K.W. … Lin L.L. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma). (PMID: 19501189) Yamashita A. … Sugiura T. (Biochim. Biophys. Acta 2009) 3 23
  3. Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells. (PMID: 17459165) Tithof P.K. … Godkin J.D. (Reprod. Biol. Endocrinol. 2007) 3 23
  4. Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma). (PMID: 15944408) Yamashita A. … Waku K. (J. Biochem. 2005) 3 23
  5. Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress. (PMID: 12502717) Asai K. … Shimizu T. (J. Biol. Chem. 2003) 3 23

Products for PLA2G4C Gene

Sources for PLA2G4C Gene

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