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Aliases for PLA2G4C Gene

Aliases for PLA2G4C Gene

  • Phospholipase A2 Group IVC 2 3 4 5
  • Phospholipase A2, Group IVC (Cytosolic, Calcium-Independent) 2 3
  • CPLA2-Gamma 3 4
  • Cytosolic Phospholipase A2 Gamma 3
  • EC 3.1.1.4 4

External Ids for PLA2G4C Gene

Previous GeneCards Identifiers for PLA2G4C Gene

  • GC19M049195
  • GC19M048919
  • GC19M053227
  • GC19M053242
  • GC19M048551
  • GC19M044932

Summaries for PLA2G4C Gene

Entrez Gene Summary for PLA2G4C Gene

  • This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for PLA2G4C Gene

PLA2G4C (Phospholipase A2 Group IVC) is a Protein Coding gene. Among its related pathways are Linoleic acid metabolism and Serotonergic synapse. GO annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is PLA2G4F.

UniProtKB/Swiss-Prot for PLA2G4C Gene

  • Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.

Tocris Summary for PLA2G4C Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G4C Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4C Gene

Genomics for PLA2G4C Gene

Regulatory Elements for PLA2G4C Gene

Enhancers for PLA2G4C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048106 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +3.0 3043 1.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS DEK SP5 PLA2G4C EMP3 PLA2G4C-AS1
GH19G048253 1.8 FANTOM5 ENCODE dbSUPER 15.2 -146.6 -146599 7.1 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 TBX21 MEF2D ZNF610 CARD8-AS1 ENSG00000268746 PLA2G4C EMP3 SNORD23 CARD8 RPL18 SYNGR4 TMEM143 KDELR1
GH19G048121 1.2 ENCODE dbSUPER 18.7 -12.2 -12176 3.8 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A YY1 TCF12 SLC30A9 GLIS2 PLA2G4C LIG1 ENSG00000269534 ENSG00000269321
GH19G048168 1.1 ENCODE 15.8 -59.7 -59655 3.1 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 PLA2G4C LIG1 ENSG00000269321
GH19G048190 0.9 ENCODE 18.6 -79.8 -79776 0.8 SIN3A FEZF1 ZNF207 FOS SP3 NFYC REST ZNF518A MBD2 GLIS1 PLA2G4C LIG1 BICRA CYTH2 ENSG00000280353 C19orf68
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLA2G4C on UCSC Golden Path with GeneCards custom track

Promoters for PLA2G4C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110660 253 801 HDGF HNRNPUL1 AGO1 SIN3A ZNF48 YY1 ZNF143 FOS PAF1 NCOA1

Genomic Location for PLA2G4C Gene

Chromosome:
19
Start:
48,047,843 bp from pter
End:
48,110,853 bp from pter
Size:
63,011 bases
Orientation:
Minus strand

Genomic View for PLA2G4C Gene

Genes around PLA2G4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4C Gene

Proteins for PLA2G4C Gene

  • Protein details for PLA2G4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UP65-PA24C_HUMAN
    Recommended name:
    Cytosolic phospholipase A2 gamma
    Protein Accession:
    Q9UP65
    Secondary Accessions:
    • B2RB71
    • B4DI40
    • O75457
    • Q6IBI8
    • Q9UG68

    Protein attributes for PLA2G4C Gene

    Size:
    541 amino acids
    Molecular mass:
    60939 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G4C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G4C Gene

Post-translational modifications for PLA2G4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLA2G4C Gene

Domains & Families for PLA2G4C Gene

Gene Families for PLA2G4C Gene

Protein Domains for PLA2G4C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLA2G4C: view

No data available for UniProtKB/Swiss-Prot for PLA2G4C Gene

Function for PLA2G4C Gene

Molecular function for PLA2G4C Gene

GENATLAS Biochemistry:
phospholipase A2,group IVB,Ca2+ independent,cytosolic,ubiquitously predominantly expressed in cardiac and skeletal muscle paralog of PLA2G2A
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=218 pmol/min/mg enzyme {ECO:0000269 PubMed:10085124};
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Not regulated by calcium.
UniProtKB/Swiss-Prot Function:
Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.

Enzyme Numbers (IUBMB) for PLA2G4C Gene

Gene Ontology (GO) - Molecular Function for PLA2G4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity TAS --
GO:0004623 phospholipase A2 activity TAS --
GO:0005543 phospholipid binding NAS 10085124
GO:0008970 phosphatidylcholine 1-acylhydrolase activity TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLA2G4C: view
genes like me logo Genes that share phenotypes with PLA2G4C: view

Animal Model Products

miRNA for PLA2G4C Gene

miRTarBase miRNAs that target PLA2G4C

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G4C Gene

Localization for PLA2G4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4C Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G4C gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLA2G4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005654 nucleoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol TAS 10085124
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with PLA2G4C: view

Pathways & Interactions for PLA2G4C Gene

genes like me logo Genes that share pathways with PLA2G4C: view

Interacting Proteins for PLA2G4C Gene

Selected Interacting proteins: Q9UP65-PA24C_HUMAN for PLA2G4C Gene via IID

Gene Ontology (GO) - Biological Process for PLA2G4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 10085124
GO:0006954 inflammatory response NAS 10085124
GO:0007567 parturition NAS 10085124
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G4C: view

No data available for SIGNOR curated interactions for PLA2G4C Gene

Drugs & Compounds for PLA2G4C Gene

(12) Drugs for PLA2G4C Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
arachidonic acid Experimental Nutra Activator 30
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(13) Additional Compounds for PLA2G4C Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate
1002-84-2

(5) Tocris Compounds for PLA2G4C Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
U 73343 Analog of U 73122 (Cat. No. 1268) 142878-12-4
VU 0155069 Potent and selective PLD1 inhibitor 1130067-06-9
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor 1244640-48-9

(1) ApexBio Compounds for PLA2G4C Gene

Compound Action Cas Number
PACOCF3 CPLA2 and iPLA2 inhibitor 141022-99-3
genes like me logo Genes that share compounds with PLA2G4C: view

Transcripts for PLA2G4C Gene

Unigene Clusters for PLA2G4C Gene

Phospholipase A2, group IVC (cytosolic, calcium-independent):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4C Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - - - -
SP7:
SP8: - - - - - - - - -
SP9: - -
SP10: - - - -
SP11: - -
SP12: - - - - - - - - - - -
SP13:
SP14:

ExUns: 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PLA2G4C Gene

GeneLoc Exon Structure for
PLA2G4C
ECgene alternative splicing isoforms for
PLA2G4C

Expression for PLA2G4C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4C Gene

This gene is overexpressed in Muscle - Skeletal (x5.4).

Protein differential expression in normal tissues from HIPED for PLA2G4C Gene

This gene is overexpressed in Serum (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLA2G4C Gene



Protein tissue co-expression partners for PLA2G4C Gene

NURSA nuclear receptor signaling pathways regulating expression of PLA2G4C Gene:

PLA2G4C

SOURCE GeneReport for Unigene cluster for PLA2G4C Gene:

Hs.631562

mRNA Expression by UniProt/SwissProt for PLA2G4C Gene:

Q9UP65-PA24C_HUMAN
Tissue specificity: Highly expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for PLA2G4C Gene

  • Nervous system(4.9)
  • Muscle(4.4)
  • Liver(4.2)
  • Pancreas(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with PLA2G4C: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G4C Gene

Orthologs for PLA2G4C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G4C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G4C 34 35
  • 98.99 (n)
mouse
(Mus musculus)
Mammalia Pla2g4c 34 16 35
  • 68.7 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 41 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 34 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:101699 34
  • 48.64 (n)
PLA2G4C (3 of 5) 35
  • 29 (a)
OneToMany
PLA2G4C (1 of 5) 35
  • 27 (a)
OneToMany
PLA2G4C (2 of 5) 35
  • 27 (a)
OneToMany
PLA2G4C (4 of 5) 35
  • 27 (a)
OneToMany
PLA2G4C (5 of 5) 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
Species where no ortholog for PLA2G4C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G4C Gene

ENSEMBL:
Gene Tree for PLA2G4C (if available)
TreeFam:
Gene Tree for PLA2G4C (if available)

Paralogs for PLA2G4C Gene

Paralogs for PLA2G4C Gene

genes like me logo Genes that share paralogs with PLA2G4C: view

Variants for PLA2G4C Gene

Sequence variations from dbSNP and Humsavar for PLA2G4C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000014696 -- 48,103,062(+) GAGAT(A/G)GGGTC intron-variant
rs1000167431 -- 48,109,052(+) TTTTG(C/G)CCTCT intron-variant
rs1000242388 -- 48,068,944(+) AGTGA(C/T)TCACA intron-variant
rs1000265144 -- 48,054,546(+) TCCTG(A/C)CCTTG intron-variant
rs1000315187 -- 48,069,913(+) GCACC(C/T)ACCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4C Gene

Variant ID Type Subtype PubMed ID
dgv3610n100 CNV gain 25217958
dgv3611n100 CNV gain 25217958
esv2666003 CNV deletion 23128226
esv3406045 CNV insertion 20981092
esv34181 CNV loss 18971310
esv3644572 CNV loss 21293372
esv3644573 CNV loss 21293372
esv3644574 CNV gain 21293372
esv3644575 CNV loss 21293372
esv3893228 CNV loss 25118596
nsv1058622 CNV gain 25217958
nsv1058785 CNV gain 25217958
nsv1062163 CNV gain 25217958
nsv2516 CNV insertion 18451855
nsv2517 CNV insertion 18451855
nsv833853 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for PLA2G4C Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.09; 90.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G4C Gene

Human Gene Mutation Database (HGMD)
PLA2G4C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4C Gene

Disorders for PLA2G4C Gene

Relevant External Links for PLA2G4C

Genetic Association Database (GAD)
PLA2G4C
Human Genome Epidemiology (HuGE) Navigator
PLA2G4C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G4C

No disorders were found for PLA2G4C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G4C Gene

Publications for PLA2G4C Gene

  1. A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2. (PMID: 9705332) Underwood K.W. … Lin L.L. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis. (PMID: 14529291) Jenkins C.M. … Gross R.W. (Biochemistry 2003) 3 4 22 64
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth. (PMID: 21184677) Plunkett J. … Muglia L.J. (BMC Med Genomics 2010) 3 46 64

Products for PLA2G4C Gene

Sources for PLA2G4C Gene

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