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Aliases for PLA2G4B Gene

Aliases for PLA2G4B Gene

  • Phospholipase A2 Group IVB 4 5 2 3
  • Phospholipase A2, Group IVB (Cytosolic) 2 3
  • CPLA2-Beta 3 4
  • EC 3.1.1.4 4 63
  • HsT16992 3

External Ids for PLA2G4B Gene

Previous GeneCards Identifiers for PLA2G4B Gene

  • GC15P037488
  • GC15P035016
  • GC15P039699
  • GC15P039836
  • GC15P039907
  • GC15P042120
  • GC15P042129
  • GC15P018979

Summaries for PLA2G4B Gene

Entrez Gene Summary for PLA2G4B Gene

  • This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLA2G4B Gene

PLA2G4B (Phospholipase A2 Group IVB) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is JMJD7-PLA2G4B.

UniProtKB/Swiss-Prot for PLA2G4B Gene

  • Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.

Tocris Summary for PLA2G4B Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4B Gene

Genomics for PLA2G4B Gene

Regulatory Elements for PLA2G4B Gene

Genomic Location for PLA2G4B Gene

Chromosome:
15
Start:
41,837,775 bp from pter
End:
41,848,148 bp from pter
Size:
10,374 bases
Orientation:
Plus strand

Genomic View for PLA2G4B Gene

Genes around PLA2G4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4B Gene

Proteins for PLA2G4B Gene

  • Protein details for PLA2G4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C869-PA24B_HUMAN
    Recommended name:
    Cytosolic phospholipase A2 beta
    Protein Accession:
    P0C869
    Secondary Accessions:
    • B4DRT9
    • O95712
    • Q19KD5
    • Q19KD6
    • Q59GF9
    • Q8TB10
    • Q9UKV7

    Protein attributes for PLA2G4B Gene

    Size:
    781 amino acids
    Molecular mass:
    87978 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92387.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLA2G4B Gene

neXtProt entry for PLA2G4B Gene

Proteomics data for PLA2G4B Gene at MOPED

Selected DME Specific Peptides for PLA2G4B Gene

Post-translational modifications for PLA2G4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G4B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PLA2G4B Gene

Protein Domains for PLA2G4B Gene

Suggested Antigen Peptide Sequences for PLA2G4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C869

UniProtKB/Swiss-Prot:

PA24B_HUMAN :
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Domain:
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
  • Contains 1 C2 domain.
  • Contains 1 PLA2c domain.
genes like me logo Genes that share domains with PLA2G4B: view

Function for PLA2G4B Gene

Molecular function for PLA2G4B Gene

GENATLAS Biochemistry:
phospholipase A2,group IVB,Ca2+ dependent,cytosolic,more highly expressed in cerebellum and pancreas and more abundantly in beta cells,paralog of PLA2G2A
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=7.9 pmol/min/mg enzyme (isoform 5) {ECO:0000269 PubMed:10085124}; Vmax=3.6 pmol/min/ug enzyme with cAMP as substrate (isoform 4) {ECO:0000269 PubMed:10085124}; Vmax=140 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 5) {ECO:0000269 PubMed:10085124}; Vmax=1.6 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 3) {ECO:0000269 PubMed:10085124}; Vmax=2.1 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PC as substrate (isoform 5) {ECO:0000269 PubMed:10085124}; Vmax=0.6 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 5) {ECO:0000269 PubMed:10085124}; Vmax=0.8 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 3) {ECO:0000269 PubMed:10085124}; Vmax=0.3 nmol/min/ug enzyme with 1-16:0-2-[14C]18:2-PE as substrate (isoform 3) {ECO:0000269 PubMed:10085124};
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by cytosolic Ca(2+).
UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.

Enzyme Numbers (IUBMB) for PLA2G4B Gene

Gene Ontology (GO) - Molecular Function for PLA2G4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047498 calcium-dependent phospholipase A2 activity IDA 10085124
genes like me logo Genes that share ontologies with PLA2G4B: view
genes like me logo Genes that share phenotypes with PLA2G4B: view

Animal Model Products

miRNA for PLA2G4B Gene

miRTarBase miRNAs that target PLA2G4B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G4B Gene

Localization for PLA2G4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4B Gene

Cytoplasm, cytosol.
Isoform 3: Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G4B Gene COMPARTMENTS Subcellular localization image for PLA2G4B gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
mitochondrion 5

No data available for Gene Ontology (GO) - Cellular Components for PLA2G4B Gene

Pathways & Interactions for PLA2G4B Gene

genes like me logo Genes that share pathways with PLA2G4B: view

Interacting Proteins for PLA2G4B Gene

Gene Ontology (GO) - Biological Process for PLA2G4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006954 inflammatory response NAS 10085124
GO:0019369 arachidonic acid metabolic process NAS 10085124
GO:0019722 calcium-mediated signaling NAS 10085124
genes like me logo Genes that share ontologies with PLA2G4B: view

No data available for SIGNOR curated interactions for PLA2G4B Gene

Drugs & Compounds for PLA2G4B Gene

(11) Drugs for PLA2G4B Gene - From: HMDB, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clofazimine Approved, Investigational Pharma Tuberculosis drug 21
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Stearic acid Experimental Pharma 0

(46) Additional Compounds for PLA2G4B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G4B Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7

(2) ApexBio Compounds for PLA2G4B Gene

Compound Action Cas Number
Clofazimine Tuberculosis drug 2030-63-9
Varespladib (LY315920) HnsPLA inhibitor,potent and selective 172732-68-2
genes like me logo Genes that share compounds with PLA2G4B: view

Transcripts for PLA2G4B Gene

mRNA/cDNA for PLA2G4B Gene

(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4B Gene

No ASD Table

Relevant External Links for PLA2G4B Gene

GeneLoc Exon Structure for
PLA2G4B
ECgene alternative splicing isoforms for
PLA2G4B

Expression for PLA2G4B Gene

mRNA expression in normal human tissues for PLA2G4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4B Gene

This gene is overexpressed in Brain - Cerebellum (x5.1) and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for PLA2G4B Gene

This gene is overexpressed in Urine (33.8) and Cervix (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLA2G4B Gene



mRNA Expression by UniProt/SwissProt for PLA2G4B Gene

P0C869-PA24B_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed.
genes like me logo Genes that share expression patterns with PLA2G4B: view

Protein tissue co-expression partners for PLA2G4B Gene

Primer Products

In Situ Assay Products

Orthologs for PLA2G4B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2G4B 35
  • 86.44 (n)
  • 84.84 (a)
PLA2G4B 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PLA2G4B 35
  • 85.98 (n)
  • 85.68 (a)
PLA2G4B 36
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pla2g4b 35
  • 83.29 (n)
  • 82.33 (a)
Pla2g4b 16
Pla2g4b 36
  • 84 (a)
ManyToMany
PLA2G4B 36
  • 81 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia PLA2G4B 35
  • 98.82 (n)
  • 97.39 (a)
-- 36
  • 97 (a)
ManyToMany
-- 36
  • 98 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pla2g4b 35
  • 83.07 (n)
  • 82.46 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves PLA2G4B 35
  • 56.19 (n)
  • 49.53 (a)
-- 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10133 37
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
Species with no ortholog for PLA2G4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G4B Gene

ENSEMBL:
Gene Tree for PLA2G4B (if available)
TreeFam:
Gene Tree for PLA2G4B (if available)

Paralogs for PLA2G4B Gene

Paralogs for PLA2G4B Gene

(4) SIMAP similar genes for PLA2G4B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLA2G4B: view

Variants for PLA2G4B Gene

Sequence variations from dbSNP and Humsavar for PLA2G4B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_027047 -
VAR_027048 -
VAR_034365 -
VAR_060082 -

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4B Gene

Variant ID Type Subtype PubMed ID
nsv904115 CNV Loss 21882294
nsv904116 CNV Loss 21882294
nsv517631 CNV Loss 19592680
dgv2364n71 CNV Loss 21882294
nsv904119 CNV Loss 21882294
dgv2365n71 CNV Loss 21882294
nsv9244 CNV Gain 18304495
nsv1506 CNV Insertion 18451855
nsv904126 CNV Loss 21882294

Variation tolerance for PLA2G4B Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.93; 74.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G4B Gene

HapMap Linkage Disequilibrium report
PLA2G4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4B Gene

Disorders for PLA2G4B Gene

Relevant External Links for PLA2G4B

Genetic Association Database (GAD)
PLA2G4B
Human Genome Epidemiology (HuGE) Navigator
PLA2G4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G4B

No disorders were found for PLA2G4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G4B Gene

Publications for PLA2G4B Gene

  1. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 48 67
  2. A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2. (PMID: 9705332) Underwood K.W. … Lin L.L. (J. Biol. Chem. 1998) 2 3
  3. Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses. (PMID: 20167866) Lee I.T. … Yang C.M. (Am. J. Pathol. 2010) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for PLA2G4B Gene

Sources for PLA2G4B Gene

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