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PLA2G4A Gene

protein-coding   GIFtS: 67
GCID: GC01P186798

Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent)


(Previous symbol: PLA2G4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent)1 2     Calcium-Dependent Phospholipid-Binding Protein2
PLA2G41 2 3 5     Cytosolic Phospholipase A22
Phospholipase A2 Group IVA2 3     lysophospholipase2
cPLA22 3     Phosphatidylcholine 2-Acylhydrolase2
cPLA2-alpha2     CPLA23

External Ids:    HGNC: 90351   Entrez Gene: 53212   Ensembl: ENSG000001167117   OMIM: 6005225   UniProtKB: P477123   

Export aliases for PLA2G4A gene to outside databases

Previous GC identifers: GC01P184323 GC01P182226 GC01P183317 GC01P184037 GC01P184013 GC01P183529 GC01P185064 GC01P158032


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLA2G4A Gene:
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis
of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids.
Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate
hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces
lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased
intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to
perinuclear membrane vesicles. (provided by RefSeq, Jul 2008)

GeneCards Summary for PLA2G4A Gene:
PLA2G4A (phospholipase A2, group IVA (cytosolic, calcium-dependent)) is a protein-coding gene. Diseases associated with PLA2G4A include phospholipase a2, group iv a, deficiency of, and small bowel adenocarcinoma. GO annotations related to this gene include phospholipase A2 activity and calcium ion binding. An important paralog of this gene is PLA2G4D.

UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712
Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid.
Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

summary for PLA2G4A Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLA2G4A gene promoter:
         GR   AP-1   ATF-2   STAT5A   CRE-BP1   PPAR-gamma1   c-Jun   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2G4A promoter sequence
   Search Chromatin IP Primers for PLA2G4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLA2G4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q31.1   HGNC cytogenetic band: 1q25

PLA2G4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G4A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P186798:  view genomic region     (about GC identifiers)

Start:
186,798,032 bp from pter      End:
186,958,113 bp from pter
Size:
160,082 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712 (See protein sequence)
Recommended Name: Cytosolic phospholipase A2  
Size: 749 amino acids; 85239 Da
Subunit: Interacts with KAT5
3 PDB 3D structures from and Proteopedia for PLA2G4A:
1BCI (3D)        1CJY (3D)        1RLW (3D)    
Secondary accessions: B1AKG4 Q29R80

Explore the universe of human proteins at neXtProt for PLA2G4A: NX_P47712

Explore proteomics data for PLA2G4A at MOPED

Post-translational modifications: 

  • Activated by phosphorylation at both Ser-505 and Ser-7271
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PLA2G4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077734.1  
    ENSEMBL proteins: 
     ENSP00000356436   ENSP00000406892  
    Reactome Protein details: P47712

    PLA2G4A Human Recombinant Protein Products:

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    Novus Biologicals PLA2G4A Protein
    Novus Biologicals PLA2G4A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PLA2G4A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    PLA2G4A Assay Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: cPLA2-4A
    Phospholipase A2

    3 InterPro protein domains:
     IPR016035 Acyl_Trfase/lysoPLipase
     IPR002642 LysoPLipase_cat_dom
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry P47712

    ProtoNet protein and cluster: P47712

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB002642 Lysophospholipase
    IPB008162 Inorganic pyrophosphatase


    UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712
    Domain: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme
    activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+)
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PLA2c domain


    PLA2G4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PA24A_HUMAN, P47712
    Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid.
    Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response
    Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
    Catalytic activity: 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate
    Enzyme regulation: Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+)
    Biophysicochemical properties: Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction;
    Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction;

         Genatlas biochemistry entry for PLA2G4A:
    phospholipase A2,group IV,Ca2+ dependent,cytosolic,releasing arachidonic acid from membrane
    phospholipids,initiating the biosynthesis of prostaglandins,leukotrienes and platelet-activating factor

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004620phospholipase activity ----
    GO:0004622lysophospholipase activity IEA--
    GO:0004623phospholipase A2 activity TAS--
    GO:0005509calcium ion binding IDA9430701
    GO:0005515protein binding ----
         
    PLA2G4A for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pla2g4a) (see all 17):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  other  renal/urinary system  reproductive system 

    PLA2G4A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PLA2G4A: Pla2g4atm1Tksh Pla2g4atm1Jvb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLA2G4A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLA2G4A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLA2G4A

    miRNA
    Products:
        
    miRTarBase miRNAs that target PLA2G4A:
    hsa-mir-124-3p (MIRT022551), hsa-mir-10a-5p (MIRT047518), hsa-mir-449c-5p (MIRT052653), hsa-mir-30a-5p (MIRT028507), hsa-mir-146b-5p (MIRT041616)

    Block miRNA regulation of human, mouse, rat PLA2G4A using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PLA2G4A:
    hsa-miR-33a* hsa-miR-144 hsa-miR-4255 hsa-miR-145 hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidPLA2G4A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PLA2G4A
    Predesigned siRNA for gene silencing in human, mouse, rat PLA2G4A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PLA2G4A

    Clone
    Products:
         
    OriGene clones in human, mouse for PLA2G4A (see all 7)
    OriGene ORF clones in mouse, rat for PLA2G4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLA2G4A (NM_024420)
    Sino Biological Human cDNA Clone for PLA2G4A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G4A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PLA2G4A
    Browse ESI BIO Cell Lines and PureStem Progenitors for PLA2G4A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PA24A_HUMAN, P47712: Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a
    calcium-dependent fashion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum4
    mitochondrion4
    extracellular2
    golgi apparatus2
    nucleus2
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005794Golgi apparatus IEA--

    PLA2G4A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLA2G4A About   (see all 46)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    Fc-epsilon receptor I signaling in mast cells0.34
    VEGF signaling pathway0.39
    2Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Hydrolysis of LPC0.00
    Phospholipid metabolism0.64
    Acyl chain remodelling of PG0.00
    Glycerophospholipid metabolism0.62
    Acyl chain remodeling of CL0.00
    Synthesis of PA0.33
    Acyl chain remodelling of PI0.00
    3Ca-dependent events
    Ca-dependent events0.93
    Opioid Signalling0.54
    PLC beta mediated events0.67
    Neurophysiological process PGE2 induced pain processing0.38
    G-protein mediated events0.65
    4Acyl chain remodelling of PC
    Acyl chain remodelling of PE0.85
    Ether lipid metabolism0.48
    Acyl chain remodelling of PC0.85
    Acyl chain remodelling of PS0.00
    5Arachidonic acid metabolism
    Linoleic acid metabolism0.64
    Arachidonic acid metabolism0.41
    alpha-Linolenic acid metabolism0.64
    Arachidonic acid metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PLA2G4A
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLA2G4A (see all 12)
        Chemokine Signaling
    DHA Signaling
    VEGF Family Ligands and Receptor Interactions
    Antioxidant Action of Vitamin-C
    LDL Oxidation in Atherogenesis

    1 Cell Signaling Technology (CST) Pathway for PLA2G4A
        Ca, cAMP and Lipid Signaling

    Selected GeneGo (Thomson Reuters) Pathways for PLA2G4A (see all 8)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Anandamide biosynthesis and metabolism
    Immune response Fc epsilon RI pathway
    Immune response CCR3 signaling in eosinophils
    Development A1 receptor signaling

    Selected BioSystems Pathways for PLA2G4A (see all 8)
        p38 MAPK Signaling Pathway
    AGE/RAGE pathway
    IL-5 Signaling Pathway
    Prostaglandin Synthesis and Regulation
    Integrated Pancreatic Cancer Pathway


    Selected Reactome Pathways for PLA2G4A (see all 12)
        Acyl chain remodelling of PE
    Synthesis of PA
    Acyl chain remodelling of PC
    Arachidonic acid metabolism
    Acyl chain remodelling of PG

    3 PharmGKB Pathways for PLA2G4A
        Celecoxib Pathway, Pharmacodynamics
    Leukotriene modifiers pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PLA2G4A) (see all 19):
        Glycerophospholipid metabolism
    Ether lipid metabolism
    Arachidonic acid metabolism
    Linoleic acid metabolism
    alpha-Linolenic acid metabolism


    PLA2G4A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLA2G4A: 
              VEGF Signaling in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLA2G4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLA2G4A (P477123 ENSP000003564364) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP3P425743, ENSP000003110324I2D: score=2 STRING: ENSP00000311032
    CASP4P496623, ENSP000003885664I2D: score=1 STRING: ENSP00000388566
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    MKNK1Q9BUB53, ENSP000003610144I2D: score=1 STRING: ENSP00000361014
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0006663platelet activating factor biosynthetic process NAS9430701
    GO:0006690icosanoid metabolic process NAS9430701
    GO:0007596blood coagulation TAS--

    PLA2G4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for PLA2G4A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLA2G4A (see all 2146)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    Alpha-Linolenic acid(9,12,15)-linolenate (see all 23)463-40-1--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    CalciumCa (see all 2)7440-70-2--
    Glycerophosphocholine2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt (see all 21)28319-77-9--
    Glycerylphosphorylethanolamine2-aminoethyl ester 1-Glycerophosphoric acid (see all 10)1190-00-7--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--

    Selected DrugBank Compounds for PLA2G4A (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Carbachol-- 51-83-2enzymeinducer7730640 1417779 2519894 1373616 1636494 6091414 8344290
    Quinacrine-- 83-89-6targetinhibitor9480923 12582837 12110374
    Ethyl carbamateAethylcarbamat [german] (see all 20)51-79-6enzymesubstrate9297603 15626436
    Fluticasone Propionate-- 80474-14-2targetinhibitor10351938 15083746
    SuraminBayer 205 (see all 6)145-63-1enzymeinhibitor19251299 19169647
    AldesleukinIL-2 (see all 4)85898-30-2enzymeinducer8536274
    Carbenicillinalpha-Carboxybenzylpencillin (see all 7)4697-36-3enzymeinhibitor541266
    Epirubicin-- 56420-45-2enzymeinhibitor8347160
    Fluocinolone Acetonideflucinolone (see all 4)67-73-2enzymeinhibitor6743552
    Niflumic Acid2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid (see all 13)4394-00-7target--16301791

    Selected Novoseek inferred chemical compound relationships for PLA2G4A gene (see all 107)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aacocf3 95.3 144 8195210 (3), 8018213 (3), 10477614 (2), 12077117 (2) (see all 77)
    arachidonic acid 93.5 884 9525925 (7), 7575453 (6), 17713604 (6), 11369000 (6) (see all 99)
    mafp 88.5 53 8695655 (2), 8619991 (1), 9806761 (1), 12531432 (1) (see all 23)
    ly311727 82.2 2 12077117 (1), 11897617 (1)
    bromoenol lactone 81.9 9 17187973 (1), 12077117 (1), 15779087 (1), 9357962 (1) (see all 5)
    pge2 78.3 172 7480804 (5), 1429687 (4), 7957239 (3), 8928731 (3) (see all 66)
    1-stearoyl-2-arachidonylphosphatidylcholine 76.4 8 11099485 (3), 9425121 (1), 9240604 (1)
    scalaradial 74.6 4 19265167 (1), 9729536 (1)
    ceramide 1-phosphate 74.2 35 14676210 (7), 17472963 (7), 19101626 (4), 17890681 (4) (see all 6)
    mk 886 72.7 3 12531432 (1), 11470254 (1)



    PLA2G4A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PLA2G4A gene: 
    NM_024420.2  

    Unigene Cluster for PLA2G4A:

    Phospholipase A2, group IVA (cytosolic, calcium-dependent)
    Hs.497200  [show with all ESTs]
    Unigene Representative Sequence: NM_024420
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367466(uc001gsc.3 uc010pos.2) ENST00000466600 ENST00000442353


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PLA2G4A using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PLA2G4A:
    hsa-miR-33a* hsa-miR-144 hsa-miR-4255 hsa-miR-145 hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidPLA2G4A 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PLA2G4A (NM_024420)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G4A
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    Additional mRNA sequence: 

    AK290336.1 AK302938.1 BC114340.2 M68874.1 M72393.1 

    1 DOTS entry:

    DT.106598 

    Selected AceView cDNA sequences (see all 28):

    M72393 AW778943 M68874 AI984983 CD104330 BQ221445 BG210542 AI766240 
    BM791222 AU120946 NM_024420 T27650 CB985872 AA587049 AW150345 AI627464 
    BE439441 AI630935 BG217159 BG215562 AI277900 BG675386 CD698190 AI885963 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLA2G4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAAATAC
    PLA2G4A Expression
    About this image


    PLA2G4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
    PLA2G4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLA2G4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497200

    UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712
    Tissue specificity: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung
    endothelium

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PLA2G4A: 
              VEGF Signaling in human mouse rat
              Cardiotoxicity in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PLA2G4A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2g4a1 , 5 phospholipase A2, group IVA (cytosolic, calcium-dependent)1, 5 88.16(n)1
    94.91(a)1
      1 (63.51 cM)5
    187831  NM_008869.31  NP_032895.11 
     1498296185 
    chicken
    (Gallus gallus)
    Aves PLA2G4A1 phospholipase A2, group IVA (cytosolic, calcium-dependent) 77.09(n)
    83.89(a)
      396394  NM_205423.1  NP_990754.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLA2G4A6
    phospholipase A2, group IVA (cytosolic, calcium-de...
    81(a)
    1 ↔ 1
    GL343203.1(1975187-2077718)
    African clawed frog
    (Xenopus laevis)
    Amphibia pla2g4a-prov2 phospholipase A2, group IVA (cytosolic, calcium-dependent) 77.17(n)    BC056041.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpla22 cytosolic phospholipase a2 75.88(n)   30554  NM_131295.1 


    ENSEMBL Gene Tree for PLA2G4A (if available)
    TreeFam Gene Tree for PLA2G4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLA2G4A gene
    PLA2G4D2  PLA2G4B2  PLA2G4F2  PLA2G4E2  JMJD7-PLA2G4B2  PLA2G4C2  
    3 SIMAP similar genes for PLA2G4A using alignment to 4 protein entries:     PA24A_HUMAN (see all proteins):
    PLA2G4C    PLA2G4E    PLA2G4F

    PLA2G4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLA2G4A (see all 3528)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358264
    A breast cancer sample4--see VAR_0358262 H Q mis40--------
    rs1477882011,2
    C--158083242(+) TATAT-/ATTTTT 1 -- int10--------
    rs2007872071,2
    C--158097654(-) AGACTA/TTNNNN 1 -- int10--------
    rs2014949841,2
    --158108261(+) TATTT-/ATTTTT 1 -- int10--------
    rs2006946211,2
    C--158112369(+) CTTTTC/TTNNNN 1 -- int10--------
    rs3683990511,2
    C--158112369(+) CTTTT-/CTTTTT 1 -- int10--------
    rs127205601,2
    C,F--158112748(+) TAAAAA/-GTGTT 1 -- int11Minor allele frequency- -:0.32NS 174
    rs358133411,2
    C--158120450(+) GGGGG-/GTGTTC 1 -- int10--------
    rs1495705321,2
    C--158121711(+) GGCCC-/TTTTTC 1 -- int10--------
    rs1481410991,2
    C--158137785(+) ATGTG-/CACAC 
     ACACACA
    CACAT
    1 -- cds10--------

    HapMap Linkage Disequilibrium report for PLA2G4A (186798032 - 186958113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PLA2G4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720350CNV Deletion23290073
    esv1010484CNV Insertion20482838
    esv1093925CNV Insertion17803354
    nsv3877CNV Insertion18451855
    nsv466272CNV Loss19166990
    nsv872590CNV Gain21882294

    Human Gene Mutation Database (HGMD): PLA2G4A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLA2G4A
    DNA2.0 Custom Variant and Variant Library Synthesis for PLA2G4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600522    OMIM disorders: --

    Selected diseases for PLA2G4A (see all 73):    
    About MalaCards
    phospholipase a2, group iv a, deficiency of    small bowel adenocarcinoma    krabbe disease    hypereosinophilic syndrome
    vesiculitis    anoxia    familial adenomatous polyposis    schizoaffective disorder
    brain disease    cholera    encephalomyelitis    patent ductus arteriosus
    synovitis    hyperglycemia    toxoplasmosis    mood disorder
    cytomegalovirus infection    schizophrenia    ischemia    cystic fibrosis


    PLA2G4A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for PLA2G4A gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 44.8 39 9196277 (5), 19106984 (4), 15187863 (1), 8300750 (1) (see all 24)
    necrosis 37.2 34 9485014 (2), 7999086 (1), 9277444 (1), 7726846 (1) (see all 27)
    astrocytoma 21.4 14 10501211 (3), 8180824 (2), 9359863 (2), 9173894 (2) (see all 6)
    hypereosinophilic syndrome 13 1 9987681 (1)
    ehrlich ascites tumor 9.22 3 10951212 (2)
    schizophrenia 8.8 22 15276701 (3), 11807411 (2), 8873778 (2), 9857971 (1) (see all 11)
    familial adenomatous polyposis 3.88 3 16467083 (1), 10969066 (1)
    prostate cancer 3.6 1 18343442 (1)
    diabetes mellitus 2.3 1 11897617 (1)
    tuberculosis 1.95 1 11390500 (1)

    Genetic Association Database (GAD): PLA2G4A
    Human Genome Epidemiology (HuGE) Navigator: PLA2G4A (37 documents)

    Export disorders for PLA2G4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLA2G4A gene, integrated from 10 sources (see all 822):
    (articles sorted by number of sources associating them with PLA2G4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. (PubMed id 8083230)1, 2, 9 Sharp J.D....Kramer R.M. (J. Biol. Chem. 1994)
    2. Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. (PubMed id 9468497)1, 2, 9 Boersch-Haubold A.G.... Gelb M.H. (J. Biol. Chem. 1998)
    3. cPLA2 is phosphorylated and activated by MAP kinase. (PubMed id 8381049)1, 2, 9 Lin L.-L.... Davis R.J. (Cell 1993)
    4. BanI polymorphism of the cytosolic phospholipase A2 gene may confer susceptibility to the development of schizophrenia. (PubMed id 15276701)1, 4, 9 Pae C.U....Paik I.H. (amp 2004)
    5. 85-kDa cytosolic phospholipase A2 group IValpha gene promoter polymorphisms in patients with severe asthma: a gene expression and case-control study. (PubMed id 17672871)1, 4, 9 Sokolowska M....Pawliczak R. (Clin. Exp. Immunol. 2007)
    6. Allelic association analysis of phospholipase A2 genes with schizophrenia. (PubMed id 15318030)1, 4, 9 Junqueira R....Vallada H. (Psychiatr. Genet. 2004)
    7. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. (PubMed id 18471798)1, 4, 9 Valdes A.M....Spector T.D. (Am. J. Hum. Genet. 2008)
    8. Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. (PubMed id 10319815)1, 2, 9 Dessen A....Somers W.S. (Cell 1999)
    9. Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2. (PubMed id 9430701)1, 2, 9 Perisic O.... Williams R.L. (J. Biol. Chem. 1998)
    10. Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2. (PubMed id 9665851)1, 2, 9 Xu G.-Y....Cumming D.A. (J. Mol. Biol. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5321 HGNC: 9035 AceView: PLA2G4A Ensembl:ENSG00000116711 euGenes: HUgn5321
    ECgene: PLA2G4A Kegg: 5321 H-InvDB: PLA2G4A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLA2G4A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLA2G4A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/pla2g4a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PLA2G4A gene:
    Search GeneIP for patents involving PLA2G4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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