Aliases for PLA2G4A Gene
External Ids for PLA2G4A Gene
Previous HGNC Symbols for PLA2G4A Gene
Previous GeneCards Identifiers for PLA2G4A Gene
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLA2G4A Gene
PLA2G4A (Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent)) is a Protein Coding gene. Diseases associated with PLA2G4A include small bowel adenocarcinoma and krabbe disease. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is JMJD7-PLA2G4B.
UniProtKB/Swiss-Prot for PLA2G4A Gene
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.