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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLA2G4A Gene

protein-coding   GIFtS: 68
GCID: GC01P186798

Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent)


(Previous symbol: PLA2G4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent)1 2     Calcium-Dependent Phospholipid-Binding Protein2
PLA2G41 2 3 5     Cytosolic Phospholipase A22
Phospholipase A2 Group IVA2 3     lysophospholipase2
cPLA22 3     Phosphatidylcholine 2-Acylhydrolase2
cPLA2-alpha2     CPLA23

External Ids:    HGNC: 90351   Entrez Gene: 53212   Ensembl: ENSG000001167117   OMIM: 6005225   UniProtKB: P477123   

Export aliases for PLA2G4A gene to outside databases

Previous GC identifers: GC01P184323 GC01P182226 GC01P183317 GC01P184037 GC01P184013 GC01P183529 GC01P185064 GC01P158032


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLA2G4A Gene:
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis
of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids.
Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate
hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces
lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased
intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to
perinuclear membrane vesicles. (provided by RefSeq, Jul 2008)

GeneCards Summary for PLA2G4A Gene: 
PLA2G4A (phospholipase A2, group IVA (cytosolic, calcium-dependent)) is a protein-coding gene. Diseases associated with PLA2G4A include small bowel adenocarcinoma, and krabbe disease, and among its related super-pathways are Fc epsilon RI signaling pathway and Acyl chain remodelling of PI. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding. An important paralog of this gene is PLA2G4D.

UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712
Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid.
Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

summary for PLA2G4A Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLA2G4A gene promoter:
         GR   AP-1   ATF-2   STAT5A   CRE-BP1   PPAR-gamma1   c-Jun   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2G4A promoter sequence
   Search SABiosciences Chromatin IP Primers for PLA2G4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q31.1   HGNC cytogenetic band: 1q25

PLA2G4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G4A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P186798:  view genomic region     (about GC identifiers)

Start:
186,798,032 bp from pter      End:
186,958,113 bp from pter
Size:
160,082 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712 (See protein sequence)
Recommended Name: Cytosolic phospholipase A2  
Size: 749 amino acids; 85239 Da
Subunit: Interacts with KAT5
Subcellular location: Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a
calcium-dependent fashion
3 PDB 3D structures from and Proteopedia for PLA2G4A:
1BCI (3D)        1CJY (3D)        1RLW (3D)    
Secondary accessions: B1AKG4 Q29R80

Explore the universe of human proteins at neXtProt for PLA2G4A: NX_P47712

Explore proteomics data for PLA2G4A at MOPED 

Post-translational modifications:

  • UniProtKB: Activated by phosphorylation at both Ser-505 and Ser-727
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P47712

  • PLA2G4A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLA2G4A Protein Expression
    REFSEQ proteins: NP_077734.1  
    ENSEMBL proteins: 
     ENSP00000356436   ENSP00000406892  
    Reactome Protein details: P47712
    Human Recombinant Protein Products for PLA2G4A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for PLA2G4A
    OriGene Protein Over-expression Lysate for PLA2G4A
    OriGene MassSpec for PLA2G4A 
    OriGene Custom Protein Services for PLA2G4A
    GenScript Custom Purified and Recombinant Proteins Services for PLA2G4A
    Novus Biologicals PLA2G4A Protein
    Novus Biologicals PLA2G4A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol TAS--

    PLA2G4A for ontologies           About GeneDecksing



    PLA2G4A Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for PLA2G4A 

    Assay Products for PLA2G4A: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: cPLA2-4A 
    Phospholipase A2

    5 InterPro protein domains:
     IPR016035 Acyl_Trfase/lysoPLipase
     IPR018029 C2_membr_targeting
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR002642 LysoPLipase_cat_dom
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry P47712

    ProtoNet protein and cluster: P47712

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB002642 Lysophospholipase
    IPB008162 Inorganic pyrophosphatase


    UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712
    Domain: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme
    activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+)
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PLA2c domain


    PLA2G4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PA24A_HUMAN, P47712
    Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid.
    Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response
    Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
    Catalytic activity: 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate
    Enzyme regulation: Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+)
    Biophysicochemical properties: Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction;
    Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction;

         Genatlas biochemistry entry for PLA2G4A:
    phospholipase A2,group IV,Ca2+ dependent,cytosolic,releasing arachidonic acid from membrane
    phospholipids,initiating the biosynthesis of prostaglandins,leukotrienes and platelet-activating factor

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004620phospholipase activity ----
    GO:0004622lysophospholipase activity IEA--
    GO:0004623phospholipase A2 activity TAS--
    GO:0005509calcium ion binding IDA9430701
    GO:0005515protein binding ----
         
    PLA2G4A for ontologies           About GeneDecksing


    Phenotypes:
         15/17 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pla2g4a) (see all 17):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  other  renal/urinary system  reproductive system 

    PLA2G4A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PLA2G4A: Pla2g4atm1Tksh Pla2g4atm1Jvb

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLA2G4A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLA2G4A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLA2G4A 

    miRNA
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    hsa-miR-33a* hsa-miR-144 hsa-miR-4255 hsa-miR-145 hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidPLA2G4A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: PLA2G4A (NM_024420)
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G4A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLA2G4A About   (see all 50)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Fc-epsilon receptor I signaling in mast cells0.33
    Fc epsilon RI signaling pathway0.40
    Immune response CD16 signaling in NK cells0.32
    VEGF signaling pathway0.39
    2Acyl chain remodelling of PE
    Acyl chain remodelling of PE0.85
    Acyl chain remodelling of PG0.62
    Acyl chain remodelling of PC0.85
    Ether lipid metabolism0.46
    Acyl chain remodelling of PS0.74
    Synthesis of PA0.41
    Acyl chain remodelling of PI0.65
    Hydrolysis of LPC0.33
    3Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    4Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    5Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    Arachidonic acid metabolism0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for PLA2G4A (see all 8)
        Immune response CD16 signaling in NK cells
    Development A1 receptor signaling
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Development Alpha-2 adrenergic receptor activation of ERK
    Immune response CCR3 signaling in eosinophils

    1 R&D Systems Pathway for PLA2G4A
        VEGF - VEGF R2 Signaling Pathways

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLA2G4A (see all 12)
        Chemokine Signaling
    DHA Signaling
    VEGF Family Ligands and Receptor Interactions
    Antioxidant Action of Vitamin-C
    LDL Oxidation in Atherogenesis

    1 Cell Signaling Technology (CST) Pathway for PLA2G4A
        Ca, cAMP and Lipid Signaling

    5/8 GeneGo (Thomson Reuters) Pathways for PLA2G4A (see all 8)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Anandamide biosynthesis and metabolism
    Immune response Fc epsilon RI pathway
    Immune response CCR3 signaling in eosinophils
    Development A1 receptor signaling

    5/8 BioSystems Pathways for PLA2G4A (see all 8)
        p38 MAPK Signaling Pathway
    AGE/RAGE pathway
    IL-5 Signaling Pathway
    Prostaglandin Synthesis and Regulation
    Integrated Pancreatic Cancer Pathway


    5/26        Reactome Pathways for PLA2G4A (see all 26)
        Synthesis of PA
    Metabolism
    Acyl chain remodelling of PC
    Arachidonic acid metabolism
    Platelet homeostasis

    3 PharmGKB Pathways for PLA2G4A
        Celecoxib Pathway, Pharmacodynamics
    Leukotriene modifiers pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    5/16         Kegg Pathways  (Kegg details for PLA2G4A) (see all 16):
        Glycerophospholipid metabolism
    Ether lipid metabolism
    Arachidonic acid metabolism
    Linoleic acid metabolism
    alpha-Linolenic acid metabolism


    PLA2G4A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLA2G4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/124 Interacting proteins for PLA2G4A (P477123 ENSP000003564364) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP3P425743, ENSP000003110324I2D: score=2 STRING: ENSP00000311032
    CASP4P496623, ENSP000003885664I2D: score=1 STRING: ENSP00000388566
    GPNMBQ149563, ENSP000003714204I2D: score=1 STRING: ENSP00000371420
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    GRIN2BQ132243, ENSP000002795934I2D: score=1 STRING: ENSP00000279593
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0006663platelet activating factor biosynthetic process NAS9430701
    GO:0006690icosanoid metabolic process NAS9430701
    GO:0007596blood coagulation TAS--

    PLA2G4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLA2G4A for compounds           About GeneDecksing

    EMD Millipore small molecules for PLA2G4A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PLA2G4A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    10/2146 HMDB Compounds for PLA2G4A (see all 2146)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    Alpha-Linolenic acid(9,12,15)-linolenate (see all 23)463-40-1--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    CalciumCa (see all 2)7440-70-2--
    Glycerophosphocholine2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt (see all 21)28319-77-9--
    Glycerylphosphorylethanolamine2-aminoethyl ester 1-Glycerophosphoric acid (see all 10)1190-00-7--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--

    10/12 DrugBank Compounds for PLA2G4A (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Carbachol-- 51-83-2enzymeinducer7730640 1417779 2519894 1373616 1636494 6091414 8344290
    Quinacrine-- 83-89-6targetinhibitor9480923 12582837 12110374
    Ethyl carbamateAethylcarbamat [german] (see all 20)51-79-6enzymesubstrate9297603 15626436
    Fluticasone Propionate-- 80474-14-2targetinhibitor10351938 15083746
    SuraminBayer 205 (see all 6)145-63-1enzymeinhibitor19251299 19169647
    AldesleukinIL-2 (see all 4)85898-30-2enzymeinducer8536274
    Carbenicillinalpha-Carboxybenzylpencillin (see all 7)4697-36-3enzymeinhibitor541266
    Epirubicin-- 56420-45-2enzymeinhibitor8347160
    Fluocinolone Acetonideflucinolone (see all 4)67-73-2enzymeinhibitor6743552
    Niflumic Acid2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid (see all 13)4394-00-7target--16301791

    10/107 Novoseek inferred chemical compound relationships for PLA2G4A gene (see all 107)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aacocf3 95.3 144 8195210 (3), 8018213 (3), 10477614 (2), 12077117 (2) (see all 77)
    arachidonic acid 93.5 884 9525925 (7), 7575453 (6), 17713604 (6), 11369000 (6) (see all 99)
    mafp 88.5 53 8695655 (2), 8619991 (1), 9806761 (1), 12531432 (1) (see all 23)
    ly311727 82.2 2 12077117 (1), 11897617 (1)
    bromoenol lactone 81.9 9 17187973 (1), 12077117 (1), 15779087 (1), 9357962 (1) (see all 5)
    pge2 78.3 172 7480804 (5), 1429687 (4), 7957239 (3), 8928731 (3) (see all 66)
    1-stearoyl-2-arachidonylphosphatidylcholine 76.4 8 11099485 (3), 9425121 (1), 9240604 (1)
    scalaradial 74.6 4 19265167 (1), 9729536 (1)
    ceramide 1-phosphate 74.2 35 14676210 (7), 17472963 (7), 19101626 (4), 17890681 (4) (see all 6)
    mk 886 72.7 3 12531432 (1), 11470254 (1)

    Search CenterWatch for drugs/clinical trials and news about PLA2G4A / PA24A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLA2G4A gene: 
    NM_024420.2  

    Unigene Cluster for PLA2G4A:

    Phospholipase A2, group IVA (cytosolic, calcium-dependent)
    Hs.497200  [show with all ESTs]
    Unigene Representative Sequence: NM_024420
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367466(uc001gsc.3 uc010pos.2) ENST00000466600 ENST00000442353


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    Additional mRNA sequence: 

    AK290336.1 AK302938.1 BC114340.2 M68874.1 M72393.1 

    1 DOTS entry:

    DT.106598 

    24/28 AceView cDNA sequences (see all 28):

    AW778943 M72393 BQ221445 CD104330 BM791222 AA587049 AU120946 M68874 
    T27650 BG210542 NM_024420 AW150345 AI984983 AI766240 CB985872 AI630935 
    BG215562 AI627464 BE439441 AI277900 BG217159 AI885963 CD698190 BE715029 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLA2G4A expression in normal human tissues (normalized intensities)      PLA2G4A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAAATAC
    PLA2G4A Expression
    About this image


    PLA2G4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 5 entries
             Ureter
             visceral organ   
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
             Human corneal endothelial cells
             huvec   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
             visceral organ/metanephros/calyx   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             brain/hindbrain/4th ventricle   

    See PLA2G4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLA2G4A

    SOURCE GeneReport for Unigene cluster: Hs.497200

    UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712
    Tissue specificity: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung
    endothelium

        SABiosciences Expression via Pathway-Focused PCR Arrays including PLA2G4A: 
              VEGF Signaling in human mouse rat
              Cardiotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PLA2G4A gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2g4a1 , 5 phospholipase A2, group IVA (cytosolic, calcium-dependent)1, 5 88.16(n)1
    94.91(a)1
      1 (63.51 cM)5
    187831  NM_008869.31  NP_032895.11 
     1498296185 
    chicken
    (Gallus gallus)
    Aves PLA2G4A1 phospholipase A2, group IVA (cytosolic, calcium-dependent) 77.09(n)
    83.89(a)
      396394  NM_205423.1  NP_990754.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLA2G4A6
    phospholipase A2, group IVA (cytosolic, calcium-de...
    81(a)
    1 ↔ 1
    GL343203.1(1975187-2077718)
    African clawed frog
    (Xenopus laevis)
    Amphibia pla2g4a-prov2 phospholipase A2, group IVA (cytosolic, calcium-dependent) 77.17(n)    BC056041.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpla22 cytosolic phospholipase a2 75.88(n)   30554  NM_131295.1 


    ENSEMBL Gene Tree for PLA2G4A (if available)
    TreeFam Gene Tree for PLA2G4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLA2G4A gene
    PLA2G4D2  PLA2G4B2  PLA2G4F2  PLA2G4E2  JMJD7-PLA2G4B2  PLA2G4C2  
    3 SIMAP similar genes for PLA2G4A using alignment to 3 protein entries:     PA24A_HUMAN (see all proteins):
    PLA2G4C    PLA2G4E    PLA2G4F

    PLA2G4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3526 SNPs in PLA2G4A are shown (see all 3526)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358264
    A breast cancer sample4--see VAR_0358262 H Q mis40--------
    VAR_0184244
    ----see VAR_0184242 R K mis40--------
    rs1477882011,2
    C--158083242(+) TATAT-/ATTTTT 1 -- int10--------
    rs2007872071,2
    C--158097654(-) AGACTA/TTNNNN 1 -- int10--------
    rs2014949841,2
    --158108261(+) TATTT-/ATTTTT 1 -- int10--------
    rs2006946211,2
    C--158112369(+) CTTTTC/TTNNNN 1 -- int10--------
    rs3683990511,2
    C--158112369(+) CTTTT-/CTTTTT 1 -- int10--------
    rs127205601,2
    C,F--158112748(+) TAAAAA/-GTGTT 1 -- int11Minor allele frequency- -:0.32NS 174
    rs358133411,2
    C--158120450(+) GGGGG-/GTGTTC 1 -- int10--------
    rs1495705321,2
    C--158121711(+) GGCCC-/TTTTTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PLA2G4A (186798032 - 186958113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PLA2G4A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720350CNV Deletion23290073
    esv1010484CNV Insertion20482838
    esv1093925CNV Insertion17803354
    nsv3877CNV Insertion18451855
    nsv466272CNV Loss19166990
    nsv872590CNV Gain21882294


    Human Gene Mutation Database (HGMD): PLA2G4A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600522    OMIM disorders: --

    20/67 diseases for PLA2G4A (see all 67):    About MalaCards
    small bowel adenocarcinoma    krabbe disease    hypereosinophilic syndrome    vesiculitis
    biliary tract cancer    anoxia    schizoaffective disorder    brain disease
    familial adenomatous polyposis    cholera    patent ductus arteriosus    encephalomyelitis
    synovitis    mood disorder    hyperglycemia    toxoplasmosis
    cytomegalovirus infection    schizophrenia    ischemia    astrocytoma


    PLA2G4A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/41 Novoseek inferred disease relationships for PLA2G4A gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 44.8 39 9196277 (5), 19106984 (4), 15187863 (1), 8300750 (1) (see all 24)
    necrosis 37.2 34 9485014 (2), 7999086 (1), 9277444 (1), 7726846 (1) (see all 27)
    astrocytoma 21.4 14 10501211 (3), 8180824 (2), 9359863 (2), 9173894 (2) (see all 6)
    hypereosinophilic syndrome 13 1 9987681 (1)
    ehrlich ascites tumor 9.22 3 10951212 (2)
    schizophrenia 8.8 22 15276701 (3), 11807411 (2), 8873778 (2), 9857971 (1) (see all 11)
    familial adenomatous polyposis 3.88 3 16467083 (1), 10969066 (1)
    prostate cancer 3.6 1 18343442 (1)
    diabetes mellitus 2.3 1 11897617 (1)
    tuberculosis 1.95 1 11390500 (1)

    Genetic Association Database (GAD): PLA2G4A
    Human Genome Epidemiology (HuGE) Navigator: PLA2G4A (37 documents)

    Export disorders for PLA2G4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLA2G4A gene, integrated from 9 sources (see all 820):
    (articles sorted by number of sources associating them with PLA2G4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. (PubMed id 8083230)1, 2, 9 Sharp J.D....Kramer R.M. (1994)
    2. Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. (PubMed id 9468497)1, 2, 9 Boersch-Haubold A.G.... Gelb M.H. (1998)
    3. cPLA2 is phosphorylated and activated by MAP kinase. (PubMed id 8381049)1, 2, 9 Lin L.-L.... Davis R.J. (1993)
    4. BanI polymorphism of the cytosolic phospholipase A2 gene may confer susceptibility to the development of schizophrenia. (PubMed id 15276701)1, 4, 9 Pae C.U....Paik I.H. (2004)
    5. 85-kDa cytosolic phospholipase A2 group IValpha gene promoter polymorphisms in patients with severe asthma: a gene expression and case-control study. (PubMed id 17672871)1, 4, 9 Sokolowska M....Pawliczak R. (2007)
    6. Allelic association analysis of phospholipase A2 genes with schizophrenia. (PubMed id 15318030)1, 4, 9 Junqueira R....Vallada H. (2004)
    7. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. (PubMed id 18471798)1, 4, 9 Valdes A.M....Spector T.D. (2008)
    8. Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. (PubMed id 10319815)1, 2, 9 Dessen A....Somers W.S. (1999)
    9. Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2. (PubMed id 9430701)1, 2, 9 Perisic O.... Williams R.L. (1998)
    10. Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2. (PubMed id 9665851)1, 2, 9 Xu G.-Y....Cumming D.A. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5321 HGNC: 9035 AceView: PLA2G4A Ensembl:ENSG00000116711 euGenes: HUgn5321
    ECgene: PLA2G4A Kegg: 5321 H-InvDB: PLA2G4A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLA2G4A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLA2G4A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/pla2g4a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLA2G4A gene:
    Search GeneIP for patents involving PLA2G4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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