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Aliases for PLA2G4A Gene

Aliases for PLA2G4A Gene

  • Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) 2 3
  • PLA2G4 3 4 6
  • Phospholipase A2 Group IVA 3 4
  • CPLA2 3 4
  • Calcium-Dependent Phospholipid-Binding Protein 3
  • Phosphatidylcholine 2-Acylhydrolase 3
  • Cytosolic Phospholipase A2 3
  • Lysophospholipase 3
  • CPLA2-Alpha 3

External Ids for PLA2G4A Gene

Previous HGNC Symbols for PLA2G4A Gene

  • PLA2G4

Previous GeneCards Identifiers for PLA2G4A Gene

  • GC01P184323
  • GC01P182226
  • GC01P183317
  • GC01P184037
  • GC01P184013
  • GC01P183529
  • GC01P185064
  • GC01P158032

Summaries for PLA2G4A Gene

Entrez Gene Summary for PLA2G4A Gene

  • This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLA2G4A Gene

PLA2G4A (Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent)) is a Protein Coding gene. Diseases associated with PLA2G4A include small bowel adenocarcinoma and krabbe disease. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is JMJD7-PLA2G4B.

UniProtKB/Swiss-Prot for PLA2G4A Gene

  • Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

Tocris Summary for PLA2G4A Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G4A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4A Gene

Genomics for PLA2G4A Gene

Regulatory Elements for PLA2G4A Gene

Genomic Location for PLA2G4A Gene

Start:
186,828,900 bp from pter
End:
186,988,981 bp from pter
Size:
160,082 bases
Orientation:
Plus strand

Genomic View for PLA2G4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2G4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G4A Gene

Proteins for PLA2G4A Gene

  • Protein details for PLA2G4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47712-PA24A_HUMAN
    Recommended name:
    Cytosolic phospholipase A2
    Protein Accession:
    P47712
    Secondary Accessions:
    • B1AKG4
    • Q29R80

    Protein attributes for PLA2G4A Gene

    Size:
    749 amino acids
    Molecular mass:
    85239 Da
    Quaternary structure:
    • Interacts with KAT5.

    Three dimensional structures from OCA and Proteopedia for PLA2G4A Gene

neXtProt entry for PLA2G4A Gene

Proteomics data for PLA2G4A Gene at MOPED

Post-translational modifications for PLA2G4A Gene

Other Protein References for PLA2G4A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLA2G4A (cPLA2)

No data available for DME Specific Peptides for PLA2G4A Gene

Domains for PLA2G4A Gene

Gene Families for PLA2G4A Gene

Suggested Antigen Peptide Sequences for PLA2G4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47712

UniProtKB/Swiss-Prot:

PA24A_HUMAN :
  • P47712
Domain:
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
  • Contains 1 C2 domain.
  • Contains 1 PLA2c domain.
genes like me logo Genes that share domains with PLA2G4A: view

Function for PLA2G4A Gene

Molecular function for PLA2G4A Gene

GENATLAS Biochemistry:
phospholipase A2,group IV,Ca2+ dependent,cytosolic,releasing arachidonic acid from membrane phospholipids,initiating the biosynthesis of prostaglandins,leukotrienes and platelet-activating factor
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction {ECO:0000269 PubMed:8083230}; Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction {ECO:0000269 PubMed:8083230};
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
UniProtKB/Swiss-Prot CatalyticActivity:
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+)
UniProtKB/Swiss-Prot Function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

Gene Ontology (GO) - Molecular Function for PLA2G4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity --
GO:0004622 lysophospholipase activity IEA --
GO:0004623 phospholipase A2 activity TAS --
GO:0005509 calcium ion binding IDA 9430701
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PLA2G4A: view
genes like me logo Genes that share phenotypes with PLA2G4A: view

Animal Models for PLA2G4A Gene

MGI Knock Outs for PLA2G4A:

Animal Model Products

CRISPR Products

miRNA for PLA2G4A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G4A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PLA2G4A Gene

Localization for PLA2G4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4A Gene

Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G4A Gene COMPARTMENTS Subcellular localization image for PLA2G4A gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
mitochondrion 4
extracellular 2
golgi apparatus 2
nucleus 2
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PLA2G4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with PLA2G4A: view

Pathways for PLA2G4A Gene

genes like me logo Genes that share pathways with PLA2G4A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PLA2G4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006663 platelet activating factor biosynthetic process NAS 9430701
GO:0006690 icosanoid metabolic process NAS 9430701
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with PLA2G4A: view

Compounds for PLA2G4A Gene

Compound Products

(5) Tocris Compounds for PLA2G4A Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]
VU 0155069 Potent and selective PLD1 inhibitor [1130067-06-9]
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor [1244640-48-9]

(3) ApexBio Compounds for PLA2G4A Gene

Compound Action Cas Number
Clofazimine Tuberculosis drug [2030-63-9]
CP-91149 Selective inhibitor of glycogen phosphorylase [186392-40-5]
Varespladib (LY315920) "HnsPLA inhibitor,potent and selective" [172732-68-2]

(2146) HMDB Compounds for PLA2G4A Gene

Compound Synonyms Cas Number PubMed IDs
Alpha-Linolenic acid
  • (9,12,15)-linolenate
463-40-1
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Calcium
  • Ca
7440-70-2
Glycerophosphocholine
  • 2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt
28319-77-9

(12) Drugbank Compounds for PLA2G4A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aldesleukin
  • IL-2
85898-30-2 enzyme inducer
Carbachol
51-83-2 enzyme inducer
Carbenicillin
  • alpha-Carboxybenzylpencillin
4697-36-3 enzyme inhibitor
Epirubicin
56420-45-2 enzyme inhibitor
Ethyl carbamate
  • Aethylcarbamat [german]
51-79-6 enzyme substrate

(107) Novoseek inferred chemical compound relationships for PLA2G4A Gene

Compound -log(P) Hits PubMed IDs
aacocf3 95.3 87
arachidonic acid 93.5 280
mafp 88.5 24
ly311727 82.2 2
bromoenol lactone 81.9 5
genes like me logo Genes that share compounds with PLA2G4A: view

Transcripts for PLA2G4A Gene

Unigene Clusters for PLA2G4A Gene

Phospholipase A2, group IVA (cytosolic, calcium-dependent):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G4A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G4A Gene

No ASD Table

Relevant External Links for PLA2G4A Gene

GeneLoc Exon Structure for
PLA2G4A
ECgene alternative splicing isoforms for
PLA2G4A

Expression for PLA2G4A Gene

mRNA expression in normal human tissues for PLA2G4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G4A Gene

This gene is overexpressed in Bladder (4.0).

Protein differential expression in normal tissues for PLA2G4A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.3) and Uterus (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLA2G4A Gene

SOURCE GeneReport for Unigene cluster for PLA2G4A Gene Hs.497200

mRNA Expression by UniProt/SwissProt for PLA2G4A Gene

P47712-PA24A_HUMAN
Tissue specificity: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium
genes like me logo Genes that share expressions with PLA2G4A: view

Expression partners for PLA2G4A Gene

In Situ Assay Products

Orthologs for PLA2G4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2G4A 35
  • 90.61 (n)
  • 93.32 (a)
PLA2G4A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G4A 35
  • 91.32 (n)
  • 93.72 (a)
PLA2G4A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g4a 35
  • 88.16 (n)
  • 94.91 (a)
Pla2g4a 16
Pla2g4a 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G4A 35
  • 99.69 (n)
  • 100 (a)
PLA2G4A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g4a 35
  • 89.1 (n)
  • 94.79 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA2G4A 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G4A 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G4A 35
  • 77.09 (n)
  • 83.89 (a)
PLA2G4A 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G4A 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g4a 35
  • 74.5 (n)
  • 81.21 (a)
Str.20412 35
African clawed frog
(Xenopus laevis)
Amphibia pla2g4a-prov 35
zebrafish
(Danio rerio)
Actinopterygii cpla2 35
  • 67.99 (n)
  • 73.66 (a)
cpla2 36
  • 72 (a)
OneToMany
pla2g4a 36
  • 70 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2704 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2601 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6135 36
  • 47 (a)
OneToOne
Species with no ortholog for PLA2G4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G4A Gene

ENSEMBL:
Gene Tree for PLA2G4A (if available)
TreeFam:
Gene Tree for PLA2G4A (if available)

Paralogs for PLA2G4A Gene

Paralogs for PLA2G4A Gene

Selected SIMAP similar genes for PLA2G4A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PLA2G4A: view

Variants for PLA2G4A Gene

Sequence variations from dbSNP and Humsavar for PLA2G4A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs725892 -- 186,931,994(+) TGAAG(G/T)CAAGG intron-variant
rs726706 -- 186,903,322(+) AGTAC(A/G)TAAGG intron-variant
rs763419 -- 186,854,826(-) TAGAA(C/G)AATTT intron-variant
rs932476 -- 186,964,423(+) ATCTC(A/G)TCTGT intron-variant
rs969357 -- 186,950,861(+) TTTCT(A/G)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G4A Gene

Variant ID Type Subtype PubMed ID
nsv872590 CNV Gain 21882294
nsv466272 CNV Loss 19166990
esv2720350 CNV Deletion 23290073
esv1010484 CNV Insertion 20482838
esv1093925 CNV Insertion 17803354
nsv3877 CNV Insertion 18451855

Relevant External Links for PLA2G4A Gene

HapMap Linkage Disequilibrium report
PLA2G4A
Human Gene Mutation Database (HGMD)
PLA2G4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4A Gene

Disorders for PLA2G4A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PLA2G4A Gene in MalaCards »

(3) Diseases for PLA2G4A Gene including...

UniProtKB/Swiss-Prot

PA24A_HUMAN
  • Note=PLA2G4A mutations resulting in phospholipase A2 deficiency have been found in a patient affected by recurrent episodes of multiple complicated ulcers of the small intestine, not due to cyclooxygenase inhibitors use. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis (PubMed:18451993). {ECO:0000269 PubMed:18451993}.

(41) Novoseek inferred disease relationships for PLA2G4A Gene

Disease -log(P) Hits PubMed IDs
inflammation 44.8 31
necrosis 37.2 28
astrocytoma 21.4 12
hypereosinophilic syndrome 13 1
ehrlich ascites tumor 9.22 2

Relevant External Links for PLA2G4A

Genetic Association Database (GAD)
PLA2G4A
Human Genome Epidemiology (HuGE) Navigator
PLA2G4A
genes like me logo Genes that share disorders with PLA2G4A: view

No data available for OMIM , University of Copenhagen DISEASES and Genatlas for PLA2G4A Gene

Publications for PLA2G4A Gene

  1. Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2. (PMID: 1869522) Sharp J. … Kramer R. (J. Biol. Chem. 1991) 3 4 23
  2. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)- dependent translocation domain with homology to PKC and GAP. (PMID: 1904318) Clark J.D. … Knopf J.L. (Cell 1991) 3 4 23
  3. Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. (PMID: 8083230) Sharp J.D. … Kramer R.M. (J. Biol. Chem. 1994) 3 4 23
  4. cPLA2 is phosphorylated and activated by MAP kinase. (PMID: 8381049) Lin L.-L. … Davis R.J. (Cell 1993) 3 4 23
  5. Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. (PMID: 8702602) Pickard R.T. … Sharp J.D. (J. Biol. Chem. 1996) 3 4 23

Products for PLA2G4A Gene

Sources for PLA2G4A Gene

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