Aliases for PLA2G4A Gene
Aliases for PLA2G4A Gene
External Ids for PLA2G4A Gene
- HGNC: 9035
- Entrez Gene: 5321
- Ensembl: ENSG00000116711
- OMIM: 600522
- UniProtKB: P47712
Previous HGNC Symbols for PLA2G4A Gene
- PLA2G4
Previous GeneCards Identifiers for PLA2G4A Gene
- GC01P184323
- GC01P182226
- GC01P183317
- GC01P184037
- GC01P184013
- GC01P183529
- GC01P185064
- GC01P158032
Summaries for PLA2G4A Gene
-
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
GeneCards Summary for PLA2G4A Gene
PLA2G4A (Phospholipase A2 Group IVA) is a Protein Coding gene. Diseases associated with PLA2G4A include Phospholipase A2, Group Iv A, Deficiency Of and Splenic Infarction. Among its related pathways are Platelet activation and Golgi-to-ER retrograde transport. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is JMJD7-PLA2G4B.
UniProtKB/Swiss-Prot for PLA2G4A Gene
-
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
-
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G4A Gene
Genomics for PLA2G4A Gene
Regulatory Elements for PLA2G4A Gene
Enhancers for PLA2G4A Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PLA2G4A on UCSC Golden Path with GeneCards custom track
Promoters for PLA2G4A Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around PLA2G4A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PLA2G4A gene promoter:
Regulatory Element Products
Genomic Location for PLA2G4A Gene
- Chromosome:
- 1
- Start:
- 186,828,900 bp from pter
- End:
- 186,988,981 bp from pter
- Size:
- 160,082 bases
- Orientation:
- Plus strand
Genomic View for PLA2G4A Gene
Genes around PLA2G4A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q31.1 by Ensembl
- 1q31.1 by Entrez Gene
- 1q31.1 by HGNC
PLA2G4A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLA2G4A Gene
Proteins for PLA2G4A Gene
-
Protein details for PLA2G4A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P47712-PA24A_HUMAN
- Recommended name:
- Cytosolic phospholipase A2
- Protein Accession:
- P47712
- B1AKG4
- Q29R80
Protein attributes for PLA2G4A Gene
- Size:
- 749 amino acids
- Molecular mass:
- 85239 Da
- Quaternary structure:
-
- Interacts with KAT5.
Protein Expression for PLA2G4A Gene
Post-translational modifications for PLA2G4A Gene
- Activated by phosphorylation at both Ser-505 and Ser-727.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PLA2G4A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PLA2G4A (PLA2G4A)
- Cell Signaling Technology (CST) Antibodies for PLA2G4A (cPLA2)
- Novus Biologicals Antibodies for PLA2G4A
-
Cloud-Clone Corp. Antibodies for PLA2G4A
- Invitrogen Antibodies for PLA2G4A
- antibodies-online Antibodies for PLA2G4A: See all 105
- GeneTex PLA2G4A antibody for PLA2G4A
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLA2G4A
Protein Products
- R&D Systems Proteins and Enzymes for PLA2G4A
-
OriGene Purified Proteins for PLA2G4A
- Search Origene for MassSpec and Protein Over-expression Lysates for PLA2G4A
- Origene Custom Protein Services for PLA2G4A
-
Cloud-Clone Corp. Proteins for PLA2G4A
- antibodies-online Proteins for PLA2G4A: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PLA2G4A
No data available for DME Specific Peptides for PLA2G4A Gene
Domains & Families for PLA2G4A Gene
Gene Families for PLA2G4A Gene
Protein Domains for PLA2G4A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PLA2G4A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P47712UniProtKB/Swiss-Prot:
PA24A_HUMAN :- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
- Domain:
-
- The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
- Contains 1 C2 domain.
- Contains 1 PLA2c domain.
Function for PLA2G4A Gene
Molecular function for PLA2G4A Gene
- GENATLAS Biochemistry:
- phospholipase A2,group IV,Ca2+ dependent,cytosolic,releasing arachidonic acid from membrane phospholipids,initiating the biosynthesis of prostaglandins,leukotrienes and platelet-activating factor
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction {ECO:0000269 PubMed:8083230}; Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction {ECO:0000269 PubMed:8083230};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).
- UniProtKB/Swiss-Prot Function:
- Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004620 | phospholipase activity | IEA | -- |
Phenotypes for PLA2G4A Gene
- MGI mutant phenotypes for PLA2G4A:
-
inferred from 2 alleles
- cellular phenotype
- mortality/aging
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- immune system phenotype
- cardiovascular system phenotype
- growth/size/body region phenotype
- hematopoietic system phenotype
- tumorigenesis
- homeostasis/metabolism phenotype
- digestive/alimentary phenotype
- respiratory system phenotype
- nervous system phenotype
- muscle phenotype
- renal/urinary system phenotype
- other phenotype
- GenomeRNAi human phenotypes for PLA2G4A:
Animal Model Products
-
ViGene Biosciences lentiviral particle packaged cDNA for PLA2G4A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLA2G4A gene
- Search ViGene Biosciences for PLA2G4A
CRISPR Products
-
OriGene CRISPR knockouts for PLA2G4A
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4A
- GenScript: Design CRISPR guide RNA sequences for PLA2G4A
miRNA for PLA2G4A Gene
- miRTarBase miRNAs that target PLA2G4A
-
- hsa-mir-124-3p (MIRT022551)
- hsa-mir-30a-5p (MIRT028507)
- hsa-mir-146b-5p (MIRT041616)
- hsa-mir-10a-5p (MIRT047518)
- hsa-mir-449c-5p (MIRT052653)
- hsa-mir-7977 (MIRT671764)
- hsa-mir-3157-5p (MIRT671765)
- hsa-mir-24-3p (MIRT671766)
- hsa-mir-4284 (MIRT671767)
- hsa-mir-4755-3p (MIRT671768)
- hsa-mir-342-3p (MIRT671769)
- hsa-mir-4691-3p (MIRT671770)
- hsa-mir-1228-3p (MIRT671771)
- hsa-mir-665 (MIRT700757)
- hsa-mir-6771-5p (MIRT700758)
- hsa-mir-4763-3p (MIRT700759)
- hsa-mir-1207-5p (MIRT700760)
- hsa-mir-7160-5p (MIRT700761)
- hsa-mir-6722-3p (MIRT700762)
- hsa-mir-1909-3p (MIRT700763)
- hsa-mir-6884-5p (MIRT700764)
- hsa-mir-485-5p (MIRT700765)
- hsa-mir-1827 (MIRT700766)
- hsa-mir-4649-3p (MIRT700767)
- hsa-mir-6746-5p (MIRT700768)
- hsa-mir-5690 (MIRT700769)
- hsa-mir-2114-5p (MIRT700770)
- hsa-mir-5588-3p (MIRT700771)
- hsa-mir-6783-5p (MIRT700772)
- hsa-mir-4478 (MIRT700773)
- hsa-mir-4419b (MIRT700774)
- hsa-mir-3929 (MIRT700775)
- hsa-mir-940 (MIRT700776)
- hsa-mir-6893-5p (MIRT700777)
- hsa-mir-6808-5p (MIRT700778)
miRNA Products
- Search ViGene Biosciences for PLA2G4A
Clone Products
- OriGene clones in human for PLA2G4A
- OriGene ORF clones in human,mouse,rat for PLA2G4A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PLA2G4A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PLA2G4A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PLA2G4A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLA2G4A gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11990) for PLA2G4A
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PLA2G4A Gene
Localization for PLA2G4A Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLA2G4A Gene
- Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| endoplasmic reticulum | 5 |
| mitochondrion | 5 |
| nucleus | 4 |
| golgi apparatus | 3 |
| extracellular | 2 |
| plasma membrane | 2 |
| cytoskeleton | 1 |
No data available for Gene Ontology (GO) - Cellular Components for PLA2G4A Gene
Pathways & Interactions for PLA2G4A Gene
More details on SuperPathways for PLA2G4A| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis | ||
| 2 | Acyl chain remodelling of PC |
.33
|
|
| 3 | DAG and IP3 signaling | ||
| 4 | Immune response Fc epsilon RI pathway | ||
| 5 | Linoleic acid metabolism |
Pathways by source for PLA2G4A Gene
1 Cell Signaling Technology pathway for PLA2G4A Gene
8 BioSystems pathways for PLA2G4A Gene
31 Reactome pathways for PLA2G4A Gene
22 KEGG pathways for PLA2G4A Gene
8 GeneGo (Thomson Reuters) pathways for PLA2G4A Gene
1 R&D Systems pathway for PLA2G4A Gene
12 Qiagen pathways for PLA2G4A Gene
Interacting Proteins for PLA2G4A Gene
SIGNOR curated interactions for PLA2G4A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001554 | luteolysis | IEA | -- |
| GO:0006644 | phospholipid metabolic process | TAS | -- |
| GO:0006654 | phosphatidic acid biosynthetic process | TAS | -- |
| GO:0006663 | platelet activating factor biosynthetic process | NAS | 9430701 |
| GO:0006690 | icosanoid metabolic process | NAS | 9430701 |
Drugs & Compounds for PLA2G4A Gene
(75) Drugs for PLA2G4A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fluticasone propionate | Approved | Pharma | antagonist, Target, inhibitor | Selective high affinity glucocorticoid receptor agonist | 0 | |
| Fluocinolone Acetonide | Approved, Investigational | Pharma | binder, Enzyme, inhibitor | 39 | ||
| Quinacrine | Approved | Pharma | Target, inhibitor | 6 | ||
| Carbachol | Approved | Pharma | Full agonist, Agonist, Enzyme, inducer | 3 | ||
| Carbenicillin | Approved | Pharma | Enzyme, inhibitor | 1 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| glycerophosphocholine |
|
28319-77-9 | ||||
| Arachidic acid |
|
506-30-9 |
|
|||
| Glycerylphosphorylethanolamine |
|
1190-00-7 |
|
|||
| Heptadecanoic acid |
|
506-12-7 |
|
|||
| Heptadecanoyl CoA |
|
3546-17-6 |
|
(5) Tocris Compounds for PLA2G4A Gene
(3) ApexBio Compounds for PLA2G4A Gene
| Compound | Action | Cas Number |
|---|---|---|
| Clofazimine | Tuberculosis drug | 2030-63-9 |
| CP-91149 | Selective inhibitor of glycogen phosphorylase | 186392-40-5 |
| Varespladib (LY315920) | HnsPLA inhibitor,potent and selective | 172732-68-2 |
Transcripts for PLA2G4A Gene
mRNA/cDNA for PLA2G4A Gene
- (6) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (28) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PLA2G4A Gene
CRISPR Products
-
OriGene CRISPR knockouts for PLA2G4A
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4A
- GenScript: Design CRISPR guide RNA sequences for PLA2G4A
miRNA Products
- Search ViGene Biosciences for PLA2G4A
Clone Products
- OriGene clones in human for PLA2G4A
- OriGene ORF clones in human,mouse,rat for PLA2G4A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PLA2G4A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-11990) for PLA2G4A
Expression for PLA2G4A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Adult Endothelial Cells Blood Brain Barrier
- Gut Tube (Gastrointestinal Tract)
- Lung (Respiratory System)
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
- Lower Urinary Tract (Urinary System)
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for PLA2G4A Gene
This gene is overexpressed in Bladder (x4.0).
This gene is overexpressed in Peripheral blood mononuclear cells (16.3) and Uterus (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PLA2G4A Gene
SOURCE GeneReport for Unigene cluster for PLA2G4A Gene Hs.497200
mRNA Expression by UniProt/SwissProt for PLA2G4A Gene
P47712-PA24A_HUMAN
Tissue specificity:
Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
Primer Products
-
OriGene qPCR primer pairs for PLA2G4A
Orthologs for PLA2G4A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PLA2G4A 35 |
|
||
| PLA2G4A 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PLA2G4A 35 |
|
||
| PLA2G4A 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pla2g4a 35 |
|
||
| Pla2g4a 16 |
|
||||
| Pla2g4a 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PLA2G4A 35 |
|
||
| PLA2G4A 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Pla2g4a 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PLA2G4A 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PLA2G4A 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PLA2G4A 35 |
|
||
| PLA2G4A 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PLA2G4A 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pla2g4a 35 |
|
||
| Str.20412 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | pla2g4a-prov 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cpla2 35 |
|
||
| cpla2 36 |
|
OneToMany | |||
| pla2g4a 36 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2704 35 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2601 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6135 36 |
|
OneToOne |
- Species with no ortholog for PLA2G4A:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PLA2G4A Gene
(3) SIMAP similar genes for PLA2G4A Gene using alignment to 4 proteins:
Variants for PLA2G4A Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2307198 | - | 186,977,780(+) | GTACA(A/G)GGCTC | nc-transcript-variant, reference, missense | |
| rs12720588 | - | 186,932,874(+) | CCTAC(A/G)TTGCT | nc-transcript-variant, reference, missense | |
| rs28395828 | - | 186,894,140(+) | CTCTA(A/G)GGACA | nc-transcript-variant, reference, missense | |
| VAR_035826 | A breast cancer sample | ||||
| rs28395831 | - | 186,977,737(+) | CAACC(A/G)TCATC | nc-transcript-variant, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv872590 | CNV | Gain | 21882294 |
| nsv466272 | CNV | Loss | 19166990 |
| esv2720350 | CNV | Deletion | 23290073 |
| esv1010484 | CNV | Insertion | 20482838 |
| esv1093925 | CNV | Insertion | 17803354 |
| nsv3877 | CNV | Insertion | 18451855 |
Residual Variation Intolerance Score:
51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.90;
35.39% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PLA2G4A Gene
- Human Gene Mutation Database (HGMD)
- PLA2G4A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G4A Gene
Disorders for PLA2G4A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| phospholipase a2, group iv a, deficiency of |
|
|
| splenic infarction |
|
|
| anterior uveitis |
|
|
| krabbe disease |
|
|
| mood disorder |
|
|
Search PLA2G4A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PA24A_HUMAN- Note=PLA2G4A mutations resulting in phospholipase A2 deficiency have been found in a patient affected by recurrent episodes of multiple complicated ulcers of the small intestine, not due to cyclooxygenase inhibitors use. Disease features also include platelet dysfunction, and globally decreased eicosanoid synthesis (PubMed:18451993). {ECO:0000269 PubMed:18451993}.
Relevant External Links for PLA2G4A
No data available for Genatlas for PLA2G4A Gene
Publications for PLA2G4A Gene
- Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. (PMID: 8083230) Sharp J.D. … Kramer R.M. (J. Biol. Chem. 1994) 3 4 23 67
- Additive blockade of beta 2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate. (PMID: 15083746) Myo S. … Leff A.R. (Eur. Respir. J. 2004) 23 25 26
- Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. (PMID: 10351938) Sano A. … Leff A.R. (Am. J. Respir. Crit. Care Med. 1999) 23 25 26
- Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway. (PMID: 9480923) Kim B.C. … Kim J.H. (Biochem. J. 1998) 23 25 26
- Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts. (PMID: 20203101) Guo C. … Sun K. (Mol. Endocrinol. 2010) 3 23
Products for PLA2G4A Gene
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- OriGene Purified Proteins for PLA2G4A
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- OriGene qPCR primer pairs for PLA2G4A
- OriGene CRISPR knockouts for PLA2G4A
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Plasmid Preparation
- GenScript Custom Peptide Services for PLA2G4A
- Cell Signaling Technology (CST) Antibodies for PLA2G4A (cPLA2)
- Search for Antibodies & Assays
- Novus Biologicals Antibodies for PLA2G4A
- Novus Biologicals proteins and lysates for PLA2G4A
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for PLA2G4A
- Cloud-Clone Corp. Proteins for PLA2G4A
- Browse Assay Kits at Cloud-Clone Corp.
- Invitrogen Antibodies for PLA2G4A
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for PLA2G4A
- antibodies-online Antibodies for PLA2G4A: See all 105
- antibodies-online Kits for PLA2G4A: See all 38
- antibodies-online Proteins for PLA2G4A: See all 11
- Search antibodies-online for peptides
- GeneTex PLA2G4A antibody for PLA2G4A
- Search GeneTex for Proteins for PLA2G4A
- ViGene Biosciences adenoviral particle packaged cDNA for PLA2G4A gene
- ViGene Biosciences lentiviral particle packaged cDNA for PLA2G4A gene
- ViGene Biosciences lentiviral particle packaged cDNA for PLA2G4A gene
- ViGene Biosciences ready-to-package AAV shRNAs for PLA2G4A gene
- ViGene Biosciences ready-to-package AAV shRNAs for PLA2G4A gene
- ViGene Biosciences ready-to-package AAV shRNAs for PLA2G4A gene
- Search ViGene Biosciences for PLA2G4A
- Search ViGene Biosciences for PLA2G4A
- Santa Cruz Biotechnology (SCBT) Antibodies for PLA2G4A
- Search Santa Cruz Biotechnology (SCBT) for PLA2G4A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PLA2G4A
Sources for PLA2G4A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon