PLA2G4A Gene protein-coding GIFtS : 68 GCID: GC01 P186798
Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) PLA2G4 )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor PLA2G4A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) 1 2 Calcium-Dependent Phospholipid-Binding Protein2 PLA2G41 2 3 5 Cytosolic Phospholipase A22 Phospholipase A2 Group IVA2 3 lysophospholipase2 cPLA22 3 Phosphatidylcholine 2-Acylhydrolase2 cPLA2-alpha2 CPLA23
Export aliases for PLA2G4A gene to outside databases Previous GC identifers: GC01P184323 GC01P182226 GC01P183317 GC01P184037 GC01P184013 GC01P183529 GC01P185064 GC01P158032
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor PLA2G4A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PLA2G4A Gene: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysisof membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids.Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulatehemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produceslysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increasedintracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus toperinuclear membrane vesicles. (provided by RefSeq, Jul 2008) GeneCards Summary for PLA2G4A Gene: PLA2G4A (phospholipase A2, group IVA (cytosolic, calcium-dependent)) is a protein-coding gene. Diseases associated with PLA2G4A include small bowel adenocarcinoma krabbe disease related super-pathways are Fc epsilon RI signaling pathway and Acyl chain remodelling of PI . GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding . An important paralog of this gene is PLA2G4D . UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712 Function : Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid.Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response summary
for PLA2G4A Gene: Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilicmolecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, whichcleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generateslysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions includingroles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids. Gene Wiki entry for PLA2G4A Gene
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor PLA2G4A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NT_004487.19 NC_018912.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PLA2G4A gene promoter:GR AP-1 ATF-2 STAT5A CRE-BP1 PPAR-gamma1 c-Jun PPAR-gamma2 GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for PLA2G4A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G4A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q25 Ensembl cytogenetic band: 1q31.1 HGNC cytogenetic band: 1q25 PLA2G4A Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P186798: view genomic region
(about GC identifiers )
Start: 186,798,032 bp from pter End:
186,958,113 bp from pter
Size: 160,082 bases Orientation:
plus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor PLA2G4A gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712 See
protein sequence )Recommended Name: Size : 749 amino acids; 85239 DaSubunit : Interacts with KAT5Subcellular location : Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in acalcium-dependent fashion
3 PDB 3D structures from :1BCI (3D) 1CJY (3D) 1RLW (3D) Secondary accessions : B1AKG4 Q29R80Explore the universe of human proteins at neXtProt for PLA2G4A: NX_P47712 Explore proteomics data for PLA2G4A at MOPED Post-translational modifications:
UniProtKB: Activated by phosphorylation at both Ser-505 and Ser-727 View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_P47712 PLA2G4A Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins: NP_077734.1 ENSEMBL proteins: ENSP00000356436 ENSP00000406892 Reactome Protein details: P47712 Human Recombinant Protein Products for PLA2G4A: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing PLA2G4A Antibody Products: Assay Products for PLA2G4A:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains /for PLA2G4A gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section IUPHAR Guide to PHARMACOLOGY protein family classification: cPLA2 -4A Phospholipase A2 5 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry P47712 ProtoNet protein and cluster: P47712
3 Blocks protein domains : IPB000008 IPB002642 IPB008162 UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712 Domain : The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzymeactivity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) Similarity : Contains 1 C2 domainSimilarity : Contains 1 PLA2c domainAbout GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor PLA2G4A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: PA24A_HUMAN, P47712 Function : Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid.Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response Catalytic activity : Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylateCatalytic activity : 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylateEnzyme regulation : Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+)Biophysicochemical properties : Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction;Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction;
Genatlas biochemistry entry for PLA2G4A phospholipase A2,group IV,Ca2+ dependent,cytosolic,releasing arachidonic acid from membranephospholipids,initiating the biosynthesis of prostaglandins,leukotrienes and platelet-activating factor Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing Phenotypes: 15/17 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pla2g4a) (see all 17 ):About GeneDecksing Animal Models: MGI mouse knock-outs for PLA2G4A: Pla2g4a tm1Tksh Pla2g4a tm1Jvb Cell Line GenScript Custom overexpressing Cell Line Services for PLA2G4A Search LifeMap BioReagents cell lines for PLA2G4A In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G4A
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor PLA2G4A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for PLA2G4A About (see all 50 ) See pathways by source SuperPath Contained pathways About 1 Immune response Fc epsilon RI pathway 2 Acyl chain remodelling of PE 3 Glycerophospholipid biosynthesis 4 Metabolism 5 Arachidonic acid metabolism
Pathways by source See SuperPaths Show all pathways 5/8 (see all 8 )1 5/12 (see all 12 )1 5/8 (see all 8 )5/8 (see all 8 )5/26 (see all 26 )3 PLA2G4A 5/16 (Kegg details for PLA2G4A) (see all 16 ):About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLA2G4A STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/124 Interacting proteins for PLA2G4A (P47712 3 ENSP00000356436 4 via UniProtKB, MINT, STRING , and/or I2D (see all 124 )About this table Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21 ): About this table
About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor PLA2G4A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for PLA2G4A available from Tocris Bioscience About this table Compound Action
CAS
# FIPI Phospholipase D inhibitor [939055-18-2] m-3M3FBS Phospholipase C activator [200933-14-8] Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9] U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4] D609 Selective PC-PLC inhibitor [83373-60-8]
10/2146 HMDB Compounds for PLA2G4A (see all 2146 )About this table Compound Synonyms
CAS
# PubMed Ids PC(O-16:0/18:2(9Z,12Z)) 1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see
all 5 ) 88542-95-4 12486725 PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) 1-alkenyl-2-acyl-glycerophosphoethanolamine (see
all 15 ) -- 12486725 PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z)) 1-alkenyl-2-acyl-glycerophosphoethanolamine (see
all 19 ) 103597-60-0 12486725 Alpha-Linolenic acid (9,12,15)-linolenate (see
all 23 ) 463-40-1 -- Arachidic acid Arachate (see
all 10 ) 506-30-9 -- Arachidonic acid 5,8,11,14-Eicosatetraenoic acid (see
all 16 ) 506-32-1 -- Calcium Ca (see
all 2 ) 7440-70-2 -- Glycerophosphocholine 2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt (see
all 21 ) 28319-77-9 -- Glycerylphosphorylethanolamine 2-aminoethyl ester 1-Glycerophosphoric acid (see
all 10 ) 1190-00-7 -- Heptadecanoic acid Heptadecanoate (see
all 16 ) 506-12-7 --
10/12 DrugBank Compounds for PLA2G4A (see all 12 )About this table 10/107 Novoseek inferred chemical compound relationships for PLA2G4A gene (see all 107 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
aacocf3
95.3
144
8195210 (3), 8018213 (3), 10477614 (2), 12077117 (2) (see
all 77 )
arachidonic acid
93.5
884
9525925 (7), 7575453 (6), 17713604 (6), 11369000 (6) (see
all 99 )
mafp
88.5
53
8695655 (2), 8619991 (1), 9806761 (1), 12531432 (1) (see
all 23 )
ly311727
82.2
2
12077117 (1), 11897617 (1)
bromoenol lactone
81.9
9
17187973 (1), 12077117 (1), 15779087 (1), 9357962 (1) (see
all 5 )
pge2
78.3
172
7480804 (5), 1429687 (4), 7957239 (3), 8928731 (3) (see
all 66 )
1-stearoyl-2-arachidonylphosphatidylcholine
76.4
8
11099485 (3), 9425121 (1), 9240604 (1)
scalaradial
74.6
4
19265167 (1), 9729536 (1)
ceramide 1-phosphate
74.2
35
14676210 (7), 17472963 (7), 19101626 (4), 17890681 (4) (see
all 6 )
mk 886
72.7
3
12531432 (1), 11470254 (1)
PLA2G4A / PA24A
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor PLA2G4A gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PLA2G4A gene: NM_024420.2 Unigene Cluster for PLA2G4A:
Phospholipase A2, group IVA (cytosolic, calcium-dependent) Hs.497200 [show with all ESTs ] Unigene Representative Sequence: NM_024420 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000367466 (uc001gsc.3 uc010pos.2 ) ENST00000466600 ENST00000442353 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AK290336.1 AK302938.1 BC114340.2 M68874.1 M72393.1
1 DOTS entry : DT.106598
24/28 AceView cDNA sequences (see all 28 ):
AW778943 M72393 BQ221445 CD104330 BM791222 AA587049 AU120946 M68874 T27650 BG210542 NM_024420 AW150345 AI984983 AI766240 CB985872 AI630935 BG215562 AI627464 BE439441 AI277900 BG217159 AI885963 CD698190 BE715029 GeneLoc Exon Structure
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for PLA2G4A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PLA2G4A expression in normal human tissues
(normalized intensities) PLA2G4A embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: AAATAAATACAbout this image
PLA2G4A expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/21 selected tissues (see all 21 ) fully expand See PLA2G4A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PLA2G4A SOURCE GeneReport for Unigene cluster: Hs.497200 UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712 Tissue specificity : Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lungendothelium SABiosciences Expression via Pathway-Focused PCR Arrays including PLA2G4A : Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G4A
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor PLA2G4A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for PLA2G4A gene from 5/15 species (see all 15 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Pla2g4a1 5
phospholipase A2, group IVA (cytosolic, calcium-dependent)1, 5
88.16(n) 1 94.91(a) 1
1 (63.51 cM) 5 18783 1 NM_008869.3 1 NP_032895.1 1 149829618 5
chicken Aves PLA2G4A1
phospholipase A2, group IVA (cytosolic, calcium-dependent)
77.09(n) 83.89(a)
396394 NM_205423.1 NP_990754.1
lizard Reptilia PLA2G4A6
phospholipase A2, group IVA (cytosolic, calcium-de... 81(a)
1 ↔ 1
GL343203.1(1975187-2077718)
African clawed frog Amphibia pla2g4a-prov2
phospholipase A2, group IVA (cytosolic, calcium-dependent)
77.17(n)
BC056041.1
zebrafish Actinopterygii cpla22
cytosolic phospholipase a2
75.88(n)
30554 NM_131295.1
ENSEMBL Gene Tree for PLA2G4A (if available)TreeFam Gene Tree for PLA2G4A (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor PLA2G4A gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PLA2G4A gene PLA2G4D 2 PLA2G4B 2 PLA2G4F 2 PLA2G4E 2 JMJD7-PLA2G4B 2 PLA2G4C 2 3 SIMAP similar genes for PLA2G4A using alignment to 3 protein entries: PA24A_HUMAN (see all proteins ):PLA2G4C PLA2G4E PLA2G4F About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor PLA2G4A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 1 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for PLA2G4A (186798032 - 186958113 bp)
Structural Variations Database of Genomic Variants (DGV) 6 variations for PLA2G4A : About this table Human Gene Mutation Database (HGMD) : PLA2G4A SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor PLA2G4A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 600522
OMIM disorders : --20/67 (see all 67 ): About MalaCards small bowel adenocarcinoma krabbe disease hypereosinophilic syndrome vesiculitis biliary tract cancer anoxia schizoaffective disorder brain disease familial adenomatous polyposis cholera patent ductus arteriosus encephalomyelitis synovitis mood disorder hyperglycemia toxoplasmosis cytomegalovirus infection schizophrenia ischemia astrocytoma About GeneDecksing Congresses - knowledge worth sharing: The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 10/41 Novoseek inferred disease relationships for PLA2G4A gene (see all 41 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation
44.8
39
9196277 (5), 19106984 (4), 15187863 (1), 8300750 (1) (see
all 24 )
necrosis
37.2
34
9485014 (2), 7999086 (1), 9277444 (1), 7726846 (1) (see
all 27 )
astrocytoma
21.4
14
10501211 (3), 8180824 (2), 9359863 (2), 9173894 (2) (see
all 6 )
hypereosinophilic syndrome
13
1
9987681 (1)
ehrlich ascites tumor
9.22
3
10951212 (2)
schizophrenia
8.8
22
15276701 (3), 11807411 (2), 8873778 (2), 9857971 (1) (see
all 11 )
familial adenomatous polyposis
3.88
3
16467083 (1), 10969066 (1)
prostate cancer
3.6
1
18343442 (1)
diabetes mellitus
2.3
1
11897617 (1)
tuberculosis
1.95
1
11390500 (1)
Genetic Association Database (GAD): PLA2G4A Human Genome Epidemiology (HuGE) Navigator: PLA2G4A (37 documents) Export disorders for PLA2G4A gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor PLA2G4A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for PLA2G4A gene, integrated from 9 sources (see all 820 ):(articles sorted by number of sources associating them with PLA2G4A) Utopia : connect your pdf to the dynamic
Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. (PubMed id 8083230) 1 , 2 , 9(1994) Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. (PubMed id 9468497) 1 , 2 , 9(1998) cPLA2 is phosphorylated and activated by MAP kinase. (PubMed id 8381049) 1 , 2 , 9(1993) BanI polymorphism of the cytosolic phospholipase A2 gene may confer susceptibility to the development of schizophrenia. (PubMed id 15276701) 1 , 4, 9(2004) 85-kDa cytosolic phospholipase A2 group IValpha gene promoter polymorphisms in patients with severe asthma: a gene expression and case-control study. (PubMed id 17672871) 1 , 4, 9(2007) Allelic association analysis of phospholipase A2 genes with schizophrenia. (PubMed id 15318030) 1 , 4, 9(2004) Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. (PubMed id 18471798) 1 , 4, 9(2008) Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. (PubMed id 10319815) 1 , 2 , 9(1999) Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2. (PubMed id 9430701) 1 , 2 , 9(1998) Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2. (PubMed id 9665851) 1 , 2 , 9(1998)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for PLA2G4A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing PLA2G4A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing PLA2G4A gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing PLA2G4A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for PLA2G4A gene: PLA2G4A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor PLA2G4A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PLA2G4A QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G4A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for PLA2G4A (cPLA2)
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G4A
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PLA2G4A
LSBio Antibodies in human mouse rat
Jump to Section...
Aliases for PLA2G4A
Databases for PLA2G4A
Disorders / Diseases for PLA2G4A
Domains / Families for PLA2G4A
Drugs / Compounds for PLA2G4A
Expression for PLA2G4A
Function for PLA2G4A
Genomic Views for PLA2G4A
Intellectual Property for PLA2G4A
Orthologs for PLA2G4A
Paralogs for PLA2G4A
Pathways / Interactions for PLA2G4A
Products for PLA2G4A
Proteins for PLA2G4A
Publications for PLA2G4A
Search Box for PLA2G4A
Summaries for PLA2G4A
Transcripts for PLA2G4A
Variants for PLA2G4A
TOP
BOTTOM
GeneCards Homepage -
Last full update: 23 Oct 2013 -
Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014
View Random Gene
Category
Protein-coding
RNA genes
Genetic Loci
Pseudogenes
Gene clusters
Uncategorized
Any
Go
transforming growth factor, beta 1
GIFtS Group
High
Medium
Low
Any
Developed at the Crown Human Genome Center Department of Molecular Genetics
the Weizmann Institute of Science
Copyright © 1996-2014
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356980-web2.xennexinc.com
index build: 106 solr: 1.4
summary
for 
and Proteopedia 
for PLA2G4A:
GeneGo (Thomson Reuters) Pathways for PLA2G4A (
PharmGKB Pathways for 
