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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLA2G4A Gene

protein-coding GIFtS: 66
GCID: GC01P186798

phospholipase A2, group IVA (cytosolic, calcium-dependent)

(Previous symbol: PLA2G4)

Explore 70 diseases affiliated with
PLA2G4A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent)¹ ²		Calcium-Dependent Phospholipid-Binding Protein²
PLA2G4¹ ² ³ ⁵		Cytosolic Phospholipase A2²
CPLA2-Alpha¹		Lysophospholipase¹
Phospholipase A2 Group IVA² ³		Phosphatidylcholine 2-Acylhydrolase²
CPLA2³		CPLA2³

External Ids:	HGNC: 9035¹	Entrez Gene: 5321²	Ensembl: ENSG00000116711⁷	OMIM: 600522⁵	UniProtKB: P47712³

Export aliases for PLA2G4A gene to outside databases

Previous GC identifers: GC01P184323 GC01P182226 GC01P183317 GC01P184037 GC01P184013 GC01P183529 GC01P185064 GC01P158032

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLA2G4A:

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of

membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids,

including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory

responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are

converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and

phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712

Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together

with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

summary for PLA2G4A:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which

cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates

lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+

concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including

roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G4A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLA2G4A gene promoter:
GR AP-1 ATF-2 STAT5A CRE-BP1 PPAR-gamma1 c-Jun PPAR-gamma2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLA2G4A promoter sequence

Search SABiosciences Chromatin IP Primers for PLA2G4A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G4A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25 Ensembl cytogenetic band: 1q31.1 HGNC cytogenetic band: 1q25

PLA2G4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G4A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P186798: view genomic region (about GC identifiers)

Start:	186,798,032 bp from pter	End:	186,958,113 bp from pter
Size:	160,082 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712 (See protein sequence)

Recommended Name: Cytosolic phospholipase A2

Size: 749 amino acids; 85239 Da

Subunit: Interacts with KAT5

Subcellular location: Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent

fashion

3 PDB 3D structures from and Proteopedia for PLA2G4A:

1BCI (3D)

1CJY (3D)

1RLW (3D)

Secondary accessions: B1AKG4 Q29R80

Explore the universe of human proteins at neXtProt for PLA2G4A: NX_P47712

Post-translational modifications:

Activated by phosphorylation at both Ser-505 and Ser-727¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P47712

PLA2G4A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_077734.1

ENSEMBL proteins:

ENSP00000356436 ENSP00000406892

Reactome Protein details: P47712
Human Recombinant Protein Products for PLA2G4A:

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	Uscn Proteins for PLA2G4A

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	--	--
GO:0005743	mitochondrial inner membrane	TAS	--
GO:0005783	endoplasmic reticulum	--	--

PLA2G4A for ontologies About GeneDecksing

PLA2G4A Antibody Products:

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	ThermoFisher Antibodies for PLA2G4A

Assay Products for PLA2G4A:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for PLA2G4A
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	Uscn ELISAs and CLIAs for PLA2G4A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLA2G4A for domains About GeneDecksing

5 InterPro domains/families:

IPR016035 Acyl_Trfase/lysoPLipase

IPR018029 C2_membr_targeting

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR002642 LysoPLipase_cat_dom

IPR000008 C2_Ca-dep

Graphical View of Domain Structure for InterPro Entry P47712

ProtoNet protein and cluster: P47712

3 Blocks protein families:

IPB000008 C2 domain

IPB002642 Lysophospholipase

IPB008162 Inorganic pyrophosphatase

UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712

Domain: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by

presenting the active site to its substrate in response to elevations of cytosolic Ca(2+)

Similarity: Contains 1 C2 domain

Similarity: Contains 1 PLA2c domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PA24A_HUMAN, P47712

Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together

with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate

Catalytic activity: 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate

Enzyme regulation: Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+)

Biophysicochemical properties: Kinetic parameters: Vmax=2.7 umol/min/mg enzyme for the phospholipase A2 reaction;

Vmax=4.6 umol/min/mg enzyme for the lysophosphatase reaction;

Genatlas biochemistry entry for PLA2G4A:

phospholipase A2,group IV,Ca2+ dependent,cytosolic,releasing arachidonic acid from membrane phospholipids,initiating

the biosynthesis of prostaglandins,leukotrienes and platelet-activating factor

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004620	phospholipase activity	--	--
GO:0004622	lysophospholipase activity	IEA	--
GO:0004623	phospholipase A2 activity	TAS	--
GO:0005509	calcium ion binding	IDA	9665851
GO:0005544	calcium-dependent phospholipid binding	IDA	9665851

PLA2G4A for ontologies About GeneDecksing

Phenotypes:
15/17 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pla2g4a) (see all 17):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
muscle	nervous system	other	renal/urinary system	reproductive system

PLA2G4A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for PLA2G4A: Pla2g4a^tm1Tksh Pla2g4a^tm1Jvb

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PLA2G4A

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		hsa-miR-33a* hsa-miR-144 hsa-miR-4255 hsa-miR-145 hsa-miR-543
		SwitchGear 3'UTR luciferase reporter plasmid: PLA2G4A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PLA2G4A

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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: PLA2G4A (NM_024420)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G4A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/50 super-pathways (see all 50) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Acyl chain remodelling of PE

8/10 pathways (see all 10)
Acyl chain remodelling of PE	1.00	phospholipases	0.39
Acyl chain remodelling of PC	0.85	Synthesis of PA	0.31
Acyl chain remodelling of PS	0.74	Hydrolysis of LPC	0.29
Acyl chain remodelling of PI	0.62	Anandamide biosynthesis and metabolism	0.13

Opioid Signalling

	Opioid Signalling	1.00			PLC beta mediated events	0.54
	G-protein mediated events	0.55			Glutamatergic synapse	0.31

alpha-Linolenic acid metabolism

	alpha-Linolenic acid metabolism	1.00			Ether lipid metabolism	0.44
	Linoleic acid metabolism	0.52			Fat digestion and absorption	0.32

Immune response Fc epsilon RI pathway

	Immune response Fc epsilon RI pathway	1.00			Fc-epsilon receptor I signaling in mast cells	0.33
	Immune response_Fc epsilon RI pathway	0.99

Glycerophospholipid biosynthesis

	Glycerophospholipid biosynthesis	1.00			Glycerophospholipid metabolism	0.54
	Phospholipid metabolism	0.64

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for PLA2G4A (see all 8)

	Immune response CD16 signaling in NK cells
	Development A1 receptor signaling
	Development Leptin signaling via JAK/STAT and MAPK cascades
	Development Alpha-2 adrenergic receptor activation of ERK
	Immune response CCR3 signaling in eosinophils

5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLA2G4A (see all 12)

	Chemokine Signaling
	DHA Signaling
	VEGF Family Ligands and Receptor Interactions
	Antioxidant Action of Vitamin-C
	LDL Oxidation in Atherogenesis

1 Cell Signaling Technology (CST) Pathway for PLA2G4A

Ca, cAMP and Lipid Signaling

5/8 GeneGo (Thomson Reuters) Pathways for PLA2G4A (see all 8)

	Development Leptin signaling via JAK/STAT and MAPK cascades
	Anandamide biosynthesis and metabolism
	Immune response Fc epsilon RI pathway
	Immune response CCR3 signaling in eosinophils
	Development A1 receptor signaling

5/10 BioSystems Pathways for PLA2G4A (see all 10)

	p38 MAPK Signaling Pathway
	AGE/RAGE pathway
	Prostaglandin Synthesis and Regulation
	IL-5 Signaling Pathway
	Integrated Pancreatic Cancer Pathway

5/26 Reactome Pathways for PLA2G4A (see all 26)

	Synthesis of PA
	Metabolism
	Acyl chain remodelling of PC
	Arachidonic acid metabolism
	Platelet homeostasis

3 PharmGKB Pathways for PLA2G4A

	Celecoxib Pathway, Pharmacodynamics
	Leukotriene modifiers pathway, Pharmacodynamics
	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

5/17 Kegg Pathways (Kegg details for PLA2G4A) (see all 17):

	Glycerophospholipid metabolism
	Ether lipid metabolism
	Arachidonic acid metabolism
	Linoleic acid metabolism
	alpha-Linolenic acid metabolism

PLA2G4A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PLA2G4A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/123 Interacting proteins for PLA2G4A (P47712³ ENSP00000356436⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 123)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CASP3	P42574³, ENSP00000311032⁴	I2D: score=2 STRING: ENSP00000311032
MAPKAPK5	Q8IW41³, ENSP00000202788⁴	I2D: score=2 STRING: ENSP00000202788
CASP4	P49662³, ENSP00000388566⁴	I2D: score=1 STRING: ENSP00000388566
GPNMB	Q14956³, ENSP00000371420⁴	I2D: score=1 STRING: ENSP00000371420
GRIN1	Q05586³, ENSP00000360616⁴	I2D: score=1 STRING: ENSP00000360616

About this table

Gene Ontology (GO): 5/42 biological process terms (GO ID links to tree view) (see all 42): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001542	ovulation from ovarian follicle	--	--
GO:0001554	luteolysis	--	--
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006654	phosphatidic acid biosynthetic process	TAS	--
GO:0006663	platelet activating factor biosynthetic process	NAS	9430701

PLA2G4A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PLA2G4A for compounds About GeneDecksing

EMD Millipore small molecules for PLA2G4A:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLA2G4A available from Tocris Bioscience About this table

Compound	Action	CAS #
RHC 80267	Diacylglycerol lipase inhibitor	[83654-05-1]
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
OBAA	Phospholipase A2 inhibitor	[221632-26-4]
PACOCF3	Phospholipase A2 inhibitor	[141022-99-3]

10/2146 HMDB Compounds for PLA2G4A (see all 2146) About this table

Compound	Synonyms	CAS #	PubMed Ids
PC(O-16:0/18:2(9Z,12Z))	1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)	88542-95-4	12486725
PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)	--	12486725
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)	103597-60-0	12486725
Alpha-Linolenic acid	(9,12,15)-linolenate (see all 23)	463-40-1	--
Arachidic acid	Arachate (see all 10)	506-30-9	--
Arachidonic acid	5,8,11,14-Eicosatetraenoic acid (see all 16)	506-32-1	--
Calcium	Ca (see all 2)	7440-70-2	--
Glycerophosphocholine	2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt (see all 21)	28319-77-9	--
Glycerylphosphorylethanolamine	2-aminoethyl ester 1-Glycerophosphoric acid (see all 10)	1190-00-7	--
Heptadecanoic acid	Heptadecanoate (see all 16)	506-12-7	--

10/11 DrugBank Compounds for PLA2G4A (see all 11) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Carbachol	--	51-83-2	enzyme	inducer	7730640 1417779 2519894 1373616 1636494 6091414 8344290
Quinacrine	--	83-89-6	target	inhibitor	9480923 12582837 12110374
Ethyl carbamate	Aethylcarbamat [german] (see all 20)	51-79-6	enzyme	substrate	9297603 15626436
Fluticasone Propionate	--	80474-14-2	target	inhibitor	10351938 15083746
Suramin	Bayer 205 (see all 6)	145-63-1	enzyme	inhibitor	19251299 19169647
Carbenicillin	alpha-Carboxybenzylpencillin (see all 7)	4697-36-3	enzyme	inhibitor	541266
Epirubicin	--	56420-45-2	enzyme	inhibitor	8347160
Fluocinolone Acetonide	flucinolone (see all 4)	67-73-2	enzyme	inhibitor	6743552
Niflumic Acid	2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid (see all 13)	4394-00-7	target	--	16301791
Orlistat	(-)-Tetrahydrolipstatin (see all 4)	96829-58-2	enzyme	inhibitor	16911813

10/107 Novoseek chemical compound relationships for PLA2G4A gene (see all 107) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
aacocf3	95.3	144	8195210 (3), 8018213 (3), 10477614 (2), 12077117 (2) (see all 77)
arachidonic acid	93.5	884	9525925 (7), 7575453 (6), 17713604 (6), 11369000 (6) (see all 99)
mafp	88.5	53	8695655 (2), 8619991 (1), 9806761 (1), 12531432 (1) (see all 23)
ly311727	82.2	2	12077117 (1), 11897617 (1)
bromoenol lactone	81.9	9	17187973 (1), 12077117 (1), 15779087 (1), 9357962 (1) (see all 5)
pge2	78.3	172	7480804 (5), 1429687 (4), 7957239 (3), 8928731 (3) (see all 66)
1-stearoyl-2-arachidonylphosphatidylcholine	76.4	8	11099485 (3), 9425121 (1), 9240604 (1)
scalaradial	74.6	4	19265167 (1), 9729536 (1)
ceramide 1-phosphate	74.2	35	14676210 (7), 17472963 (7), 19101626 (4), 17890681 (4) (see all 6)
mk 886	72.7	3	12531432 (1), 11470254 (1)

Search CenterWatch for drugs/clinical trials and news about PLA2G4A / PA24A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLA2G4A gene:

NM_024420.2

Unigene Cluster for PLA2G4A:

Phospholipase A2, group IVA (cytosolic, calcium-dependent)

Hs.497200 [show with all ESTs]

Unigene Representative Sequence: NM_024420

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367466(uc001gsc.3 uc010pos.2) ENST00000466600 ENST00000442353

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLA2G4A
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate PLA2G4A:
		hsa-miR-33a* hsa-miR-144 hsa-miR-4255 hsa-miR-145 hsa-miR-543
		SwitchGear 3'UTR luciferase reporter plasmid: PLA2G4A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLA2G4A (see all 7) OriGene shRNA RFP: PLA2G4A OriGene siRNA: PLA2G4A
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Additional cDNA sequence:

AK290336.1 AK302938.1 BC114340.2 M68874.1 M72393.1

1 DOTS entry:

DT.106598

24/28 AceView cDNA sequences (see all 28):

AW778943 M72393 BM791222 AA587049 AW150345 BQ221445 BG210542 NM_024420

AU120946 AI984983 CB985872 AI766240 T27650 M68874 CD104330 AI627464

AI630935 BG215562 BG217159 BE439441 AI277900 AI885963 BE715029 CD698190

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLA2G4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATAAATAC

About this image

PLA2G4A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Gut Tube

Hindgut

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Hindgut

Gut Tube

Midgut

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PLA2G4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLA2G4A

SOURCE GeneReport for Unigene cluster: Hs.497200

UniProtKB/Swiss-Prot: PA24A_HUMAN, P47712

Tissue specificity: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung

endothelium

SABiosciences Expression via Pathway-Focused PCR Arrays including PLA2G4A:

VEGF Signaling in human mouse rat

Cardiotoxicity in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G4A gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLA2G4A¹	phospholipase A2, group IVA (cytosolic, calcium-dependent)	77.09(n) 83.89(a)		396394 NM_205423.1 NP_990754.1
lizard (Anolis carolinensis)	Reptilia	PLA2G4A⁶	--	80(a)	1 ↔ 1	GL343203.1(1976704-2025701)
African clawed frog (Xenopus laevis)	Amphibia	pla2g4a-prov²	phospholipase A2, group IVA (cytosolic, calcium-dependent)	77.17(n)		BC056041.1
zebrafish (Danio rerio)	Actinopterygii	cpla2²	cytosolic phospholipase a2	75.88(n)		30554 NM_131295.1

ENSEMBL Gene Tree for PLA2G4A (if available)
TreeFam Gene Tree for PLA2G4A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PLA2G4A gene

PLA2G4D² PLA2G4B² PLA2G4F² JMJD7-PLA2G4B² PLA2G4E² PLA2G4C²

3 SIMAP similar genes for PLA2G4A using alignment to 3 protein entries: PA24A_HUMAN (see all proteins):

PLA2G4C PLA2G4E PLA2G4F

PLA2G4A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs41453146^1,2	C,F,H	--	158030706(+)	`AGGAGG/ACCATA`	1	--	us2k¹		8		NS EA NA	708
rs12066511^1,2	C,H	--	158031070(+)	`AGAGTC/TTTAGA`	1	--	us2k¹		3		NS NA	184
rs11802141^1,2	C,H	--	158031186(+)	`CCTTTC/TTAGAA`	1	--	us2k¹ trp³		4		NS EA	416
rs112214529^1,2	C	--	158031459(+)	`AGGATG/AGTCTC`	1	--	us2k¹		2		NA CSA	3
rs7556320^1,2	C	--	158031533(+)	`ccaccA/Gtgccc`	1	--	us2k¹		0	--	--	--	--
rs7523149^1,2	C	--	158031534(+)	`caccgC/Tgccca`	1	--	us2k¹		1		CSA	2
rs112271551^1,2	C	--	158032148(+)	`ACTTTG/TCCTTT`	1	--	us2k¹		0	--	--	--	--
rs111406359^1,2	C	--	158032272(+)	`GCACGCA/-CACAC`	1	--	us2k¹		1		CSA	2
rs12720484^1,2	C,F	--	158032490(+)	`CAAAAG/-CGCAA`	1	--	ut5¹		1		NS	106
rs12720485^1,2	C,F,H	--	158032572(+)	`TCCTGA/CCTGAA`	1	--	ut5¹ ese³		8		NS EA NA	622

HapMap Linkage Disequilibrium report for PLA2G4A (186798032 - 186958113 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PLA2G4A: --
Human Gene Mutation Database (HGMD): PLA2G4A

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PLA2G4A for disorders           About GeneDecksing

OMIM gene information: 600522    OMIM disorders: --

20/70 diseases for PLA2G4A (see all 70):    About MalaCards

familial adenomatous polyposis patent ductus arteriosus non-small cell lung carcinoma hypereosinophilic syndrome

amyotrophic lateral sclerosis biliary tract cancer lateral sclerosis krabbe disease

cystic fibrosis schizoaffective disorder cytomegalovirus infection rheumatoid arthritis

acute myeloid leukemia polyposis mood disorder myeloid leukemia

ulcerative colitis brain disease encephalomyelitis anoxia

10/41 Novoseek disease relationships for PLA2G4A gene (see all 41) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	44.8	39	9196277 (5), 19106984 (4), 15187863 (1), 8300750 (1) (see all 24)
necrosis	37.2	34	9485014 (2), 7999086 (1), 9277444 (1), 7726846 (1) (see all 27)
astrocytoma	21.4	14	10501211 (3), 8180824 (2), 9359863 (2), 9173894 (2) (see all 6)
hypereosinophilic syndrome	13	1	9987681 (1)
ehrlich ascites tumor	9.22	3	10951212 (2)
schizophrenia	8.8	22	15276701 (3), 11807411 (2), 8873778 (2), 9857971 (1) (see all 11)
familial adenomatous polyposis	3.88	3	16467083 (1), 10969066 (1)
prostate cancer	3.6	1	18343442 (1)
diabetes mellitus	2.3	1	11897617 (1)
tuberculosis	1.95	1	11390500 (1)

Genetic Association Database (GAD): PLA2G4A
Human Genome Epidemiology (HuGE) Navigator: PLA2G4A (37 documents)

Export disorders for PLA2G4A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PLA2G4A gene, integrated from 9 sources (see all 812):
(articles sorted by number of sources associating them with PLA2G4A)

Utopia: connect your pdf to the dynamic
world of online information

Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. (PubMed id 8083230)^{1, 2, 9} Sharp J.D....Kramer R.M. (1994)
Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. (PubMed id 9468497)^{1, 2, 9} Boersch-Haubold A.G.... Gelb M.H. (1998)
cPLA2 is phosphorylated and activated by MAP kinase. (PubMed id 8381049)^{1, 2, 9} Lin L.-L.... Davis R.J. (1993)
BanI polymorphism of the cytosolic phospholipase A2 gene may confer susceptibility to the development of schizophrenia. (PubMed id 15276701)^{1, 4, 9} Pae C.U....Paik I.H. (2004)
Allelic association analysis of phospholipase A2 genes with schizophrenia. (PubMed id 15318030)^{1, 4, 9} Junqueira R....Vallada H. (2004)
Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. (PubMed id 10319815)^{1, 2, 9} Dessen A....Somers W.S. (1999)
Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2. (PubMed id 9430701)^{1, 2, 9} Perisic O.... Williams R.L. (1998)
Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2. (PubMed id 9665851)^{1, 2, 9} Xu G.-Y....Cumming D.A. (1998)
Identification of essential residues for the catalyti c function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. (PubMed id 8702602)^{1, 2, 9} Pickard R.T....Sharp J.D. (1996)
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)- dependent translocation domain with homology to PKC and GAP. (PubMed id 1904318)^{1, 2, 9} Clark J.D.... Knopf J.L. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5321	HGNC: 9035	AceView: PLA2G4A	Ensembl:ENSG00000116711	euGenes: HUgn5321
ECgene: PLA2G4A	Kegg: 5321	H-InvDB: PLA2G4A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PLA2G4A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PLA2G4A	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/pla2g4a/

Intellectual Property for PLA2G4A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PLA2G4A gene:
Search GeneIP for patents involving PLA2G4A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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PLA2G4A Gene

phospholipase A2, group IVA (cytosolic, calcium-dependent)

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PLA2G4A Gene

phospholipase A2, group IVA (cytosolic, calcium-dependent)

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