Aliases for PLA2G3 Gene
External Ids for PLA2G3 Gene
Previous GeneCards Identifiers for PLA2G3 Gene
This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]
GeneCards Summary for PLA2G3 Gene
PLA2G3 (Phospholipase A2, Group III) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PROCA1.
UniProtKB/Swiss-Prot for PLA2G3 Gene
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl-phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1-palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.