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Aliases for PLA2G3 Gene

Aliases for PLA2G3 Gene

  • Phospholipase A2 Group III 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 3 3 4
  • Phospholipase A2, Group III 2 3
  • SPLA2-III 3 4
  • Phosphatidylcholine 2-Acylhydrolase GIII 3
  • Group III Secretory Phospholipase A2 4
  • Group III Secreted Phospholipase A2 3
  • GIII-SPLA2 3
  • GIII SPLA2 4
  • EC 3.1.1.4 4
  • SPLA2III 3

External Ids for PLA2G3 Gene

Previous GeneCards Identifiers for PLA2G3 Gene

  • GC22M028226
  • GC22M029855
  • GC22M031530
  • GC22M014492

Summaries for PLA2G3 Gene

Entrez Gene Summary for PLA2G3 Gene

  • This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]

GeneCards Summary for PLA2G3 Gene

PLA2G3 (Phospholipase A2 Group III) is a Protein Coding gene. Among its related pathways are Metabolism and Fat digestion and absorption. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PROCA1.

UniProtKB/Swiss-Prot for PLA2G3 Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl-phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1-palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis.

Tocris Summary for PLA2G3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G3 Gene

Genomics for PLA2G3 Gene

Regulatory Elements for PLA2G3 Gene

Genomic Location for PLA2G3 Gene

Chromosome:
22
Start:
31,134,807 bp from pter
End:
31,140,757 bp from pter
Size:
5,951 bases
Orientation:
Minus strand

Genomic View for PLA2G3 Gene

Genes around PLA2G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G3 Gene

Proteins for PLA2G3 Gene

  • Protein details for PLA2G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ20-PA2G3_HUMAN
    Recommended name:
    Group 3 secretory phospholipase A2
    Protein Accession:
    Q9NZ20
    Secondary Accessions:
    • O95768

    Protein attributes for PLA2G3 Gene

    Size:
    509 amino acids
    Molecular mass:
    57167 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD15617.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PLA2G3 Gene

Proteomics data for PLA2G3 Gene at MOPED

Post-translational modifications for PLA2G3 Gene

  • In several cell types, the N- and C-termini are cleaved off.
  • N-glycosylation does not affect the catalytic activity, but is required for proper secretion. A nonglycosylated form was observed in several cell types.
  • Glycosylation at Asn 167, Asn 280, Asn 325, Asn 396, and Asn 439
  • Modification sites at PhosphoSitePlus

Other Protein References for PLA2G3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLA2G3 Gene

Domains & Families for PLA2G3 Gene

Gene Families for PLA2G3 Gene

Protein Domains for PLA2G3 Gene

Suggested Antigen Peptide Sequences for PLA2G3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZ20

UniProtKB/Swiss-Prot:

PA2G3_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G3: view

Function for PLA2G3 Gene

Molecular function for PLA2G3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Arachidonic acid release is markedly increased by glypican, a glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl-phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1-palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis.
UniProtKB/Swiss-Prot Induction:
By IL1B/interleukin-1 beta and TNF in microvascular endothelial cells (at protein level).

Enzyme Numbers (IUBMB) for PLA2G3 Gene

Gene Ontology (GO) - Molecular Function for PLA2G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047498 calcium-dependent phospholipase A2 activity TAS 10713052
genes like me logo Genes that share ontologies with PLA2G3: view
genes like me logo Genes that share phenotypes with PLA2G3: view

Animal Models for PLA2G3 Gene

MGI Knock Outs for PLA2G3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G3

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G3 Gene

Localization for PLA2G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G3 Gene

Secreted. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G3 Gene COMPARTMENTS Subcellular localization image for PLA2G3 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
lysosome 2
vacuole 2
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for PLA2G3 Gene

Pathways & Interactions for PLA2G3 Gene

genes like me logo Genes that share pathways with PLA2G3: view

Interacting Proteins for PLA2G3 Gene

Gene Ontology (GO) - Biological Process for PLA2G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0006644 phospholipid metabolic process IEA,TAS 10713052
GO:0007288 sperm axoneme assembly IEA --
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PLA2G3: view

No data available for SIGNOR curated interactions for PLA2G3 Gene

Drugs & Compounds for PLA2G3 Gene

(11) Drugs for PLA2G3 Gene - From: HMDB, Tocris, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(47) Additional Compounds for PLA2G3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G3 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G3: view

Transcripts for PLA2G3 Gene

mRNA/cDNA for PLA2G3 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G3 Gene

Phospholipase A2, group III:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G3 Gene

No ASD Table

Relevant External Links for PLA2G3 Gene

GeneLoc Exon Structure for
PLA2G3
ECgene alternative splicing isoforms for
PLA2G3

Expression for PLA2G3 Gene

mRNA expression in normal human tissues for PLA2G3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x11.5), Skin - Not Sun Exposed (Suprapubic) (x10.1), Esophagus - Mucosa (x9.7), Vagina (x5.5), and Cervix - Ectocervix (x5.3).

Protein differential expression in normal tissues from HIPED for PLA2G3 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G3 Gene



SOURCE GeneReport for Unigene cluster for PLA2G3 Gene Hs.149623

mRNA Expression by UniProt/SwissProt for PLA2G3 Gene

Q9NZ20-PA2G3_HUMAN
Tissue specificity: Expressed in kidney, heart, liver, and skeletal muscle. Also present in placenta and peripheral blood leukocytes. Not detected in brain, colon, thymus, spleen and small intestine. In lung, expressed in bronchial epithelial cells and alveolar macrophages, but scarcely detected in alveolar epithelium, arterial walls and interstitial fibroblasts (at protein level). In joints of osteoarthritis and rheumatoid arthritis, expressed in endothelial cells (at protein level). In normal heart, detected in some vessels. In myocardial tissues with acute infarction, expressed in vascular endothelial cells adjacent to cardiomyocytes and those in lesions with granulation. Expression in cardiomyocytes is scarce (at protein level). In uterus, breast and colon cancers, detected in tumor cells and neighboring microvascular endothelium, but not in normal glandular tissues (at protein level).
genes like me logo Genes that share expression patterns with PLA2G3: view

Protein tissue co-expression partners for PLA2G3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PLA2G3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2G3 35
  • 82.61 (n)
  • 72.83 (a)
PLA2G3 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G3 35
  • 84.62 (n)
  • 77.43 (a)
PLA2G3 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g3 35
  • 77.24 (n)
  • 67.47 (a)
Pla2g3 16
Pla2g3 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G3 35
  • 99.02 (n)
  • 97.84 (a)
PLA2G3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g3 35
  • 77.22 (n)
  • 67.54 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA2G3 36
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G3 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G3 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:123275 35
  • 46.42 (n)
  • 33.58 (a)
PLA2G3 (1 of 2) 36
  • 24 (a)
OneToMany
PLA2G3 (2 of 2) 36
  • 20 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3009 36
  • 20 (a)
ManyToMany
CG30503 36
  • 25 (a)
ManyToMany
CG42237 36
  • 14 (a)
ManyToMany
GIIIspla2 36
  • 26 (a)
ManyToMany
sPLA2 36
  • 24 (a)
ManyToMany
Species with no ortholog for PLA2G3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G3 Gene

ENSEMBL:
Gene Tree for PLA2G3 (if available)
TreeFam:
Gene Tree for PLA2G3 (if available)

Paralogs for PLA2G3 Gene

Paralogs for PLA2G3 Gene

genes like me logo Genes that share paralogs with PLA2G3: view

Variants for PLA2G3 Gene

Sequence variations from dbSNP and Humsavar for PLA2G3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2074735 - 31,139,886(-) GCACA(C/G)TGTGG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2232176 - 31,140,147(-) TGCAG(A/G/T)CATGT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2074734 - 31,140,009(-) AGTGG(C/G)AGGCA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2072193 - 31,137,810(-) CCCAG(C/G)AAAGC nc-transcript-variant, reference, missense
rs2232183 - 31,136,974(-) GCCCC(A/C/G)GGAAA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PLA2G3 Gene

Variant ID Type Subtype PubMed ID
nsv829173 CNV Loss 20364138
nsv914976 CNV Loss 21882294
nsv527382 CNV Loss 19592680

Variation tolerance for PLA2G3 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.67; 96.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G3 Gene

HapMap Linkage Disequilibrium report
PLA2G3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G3 Gene

Disorders for PLA2G3 Gene

Relevant External Links for PLA2G3

Genetic Association Database (GAD)
PLA2G3
Human Genome Epidemiology (HuGE) Navigator
PLA2G3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G3

No disorders were found for PLA2G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G3 Gene

Publications for PLA2G3 Gene

  1. Novel human secreted phospholipase A2 with homology to the group III bee venom enzyme. (PMID: 10713052) Valentin E. … Lambeau G. (J. Biol. Chem. 2000) 2 3 4 67
  2. Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation. (PMID: 19371233) Sato H. … Murakami M. (Biochem. J. 2009) 3 23
  3. Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival. (PMID: 17868035) Masuda S. … Murakami M. (Biochem. J. 2008) 3 23
  4. Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis. (PMID: 18801741) Sato H. … Murakami M. (J. Biol. Chem. 2008) 3 23
  5. Phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer. (PMID: 25964585) Kazama S. … Watanabe T. (Anticancer Res. 2015) 3

Products for PLA2G3 Gene

Sources for PLA2G3 Gene

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