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Aliases for PLA2G2F Gene

Aliases for PLA2G2F Gene

  • Phospholipase A2 Group IIF 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 2F 3 4
  • Phospholipase A2, Group IIF 2 3
  • GIIF SPLA2 3 4
  • SPLA2-IIF 3 4
  • EC 4

External Ids for PLA2G2F Gene

Previous GeneCards Identifiers for PLA2G2F Gene

  • GC01P020037
  • GC01P019500
  • GC01P019611
  • GC01P019935
  • GC01P020211
  • GC01P020338
  • GC01P020465
  • GC01P018711

Summaries for PLA2G2F Gene

GeneCards Summary for PLA2G2F Gene

PLA2G2F (Phospholipase A2 Group IIF) is a Protein Coding gene. Among its related pathways are Linoleic acid metabolism and Pancreatic secretion. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2C.

UniProtKB/Swiss-Prot for PLA2G2F Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.

Tocris Summary for PLA2G2F Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2F Gene

Genomics for PLA2G2F Gene

Regulatory Elements for PLA2G2F Gene

Enhancers for PLA2G2F Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLA2G2F on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G2F Gene

20,139,326 bp from pter
20,150,386 bp from pter
11,061 bases
Plus strand

Genomic View for PLA2G2F Gene

Genes around PLA2G2F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2F Gene

Proteins for PLA2G2F Gene

  • Protein details for PLA2G2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Group IIF secretory phospholipase A2
    Protein Accession:
    Secondary Accessions:
    • Q5R385
    • Q8N217
    • Q9H506

    Protein attributes for PLA2G2F Gene

    168 amino acids
    Molecular mass:
    18658 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G2F Gene


neXtProt entry for PLA2G2F Gene

Proteomics data for PLA2G2F Gene at MOPED

Post-translational modifications for PLA2G2F Gene

  • Glycosylation at Asn 92, Asn 102, Asn 123, and Asn 144
  • Modification sites at PhosphoSitePlus

Other Protein References for PLA2G2F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G2F Gene

Domains & Families for PLA2G2F Gene

Gene Families for PLA2G2F Gene

Protein Domains for PLA2G2F Gene

Suggested Antigen Peptide Sequences for PLA2G2F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phospholipase A2 family.
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2F: view

Function for PLA2G2F Gene

Molecular function for PLA2G2F Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.

Enzyme Numbers (IUBMB) for PLA2G2F Gene

genes like me logo Genes that share phenotypes with PLA2G2F: view

Animal Models for PLA2G2F Gene

MGI Knock Outs for PLA2G2F:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G2F Gene

Localization for PLA2G2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2F Gene


Subcellular locations from

Jensen Localization Image for PLA2G2F Gene COMPARTMENTS Subcellular localization image for PLA2G2F gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for PLA2G2F Gene

Pathways & Interactions for PLA2G2F Gene

genes like me logo Genes that share pathways with PLA2G2F: view

Interacting Proteins for PLA2G2F Gene

Gene Ontology (GO) - Biological Process for PLA2G2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0036149 phosphatidylinositol acyl-chain remodeling TAS --
GO:0036150 phosphatidylserine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with PLA2G2F: view

No data available for SIGNOR curated interactions for PLA2G2F Gene

Drugs & Compounds for PLA2G2F Gene

(9) Drugs for PLA2G2F Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(47) Additional Compounds for PLA2G2F Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G2F Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G2F: view

Transcripts for PLA2G2F Gene

mRNA/cDNA for PLA2G2F Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G2F Gene

Phospholipase A2, group IIF:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2F Gene

No ASD Table

Relevant External Links for PLA2G2F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLA2G2F Gene

mRNA expression in normal human tissues for PLA2G2F Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G2F Gene

This gene is overexpressed in Bladder (x20.3), Skin - Not Sun Exposed (Suprapubic) (x15.9), and Skin - Sun Exposed (Lower leg) (x15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G2F Gene

SOURCE GeneReport for Unigene cluster for PLA2G2F Gene Hs.302034

mRNA Expression by UniProt/SwissProt for PLA2G2F Gene

Tissue specificity: Expressed at high levels in placenta, testis, thymus and at lower levels in heart, kidney, liver and prostate.
genes like me logo Genes that share expression patterns with PLA2G2F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for PLA2G2F Gene

Orthologs for PLA2G2F Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2F Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLA2G2F 35
  • 82.9 (n)
  • 75.13 (a)
PLA2G2F 36
  • 75 (a)
(Canis familiaris)
Mammalia PLA2G2F 35
  • 83.17 (n)
  • 75.71 (a)
PLA2G2F 36
  • 77 (a)
(Mus musculus)
Mammalia Pla2g2f 35
  • 80.45 (n)
  • 72.6 (a)
Pla2g2f 16
Pla2g2f 36
  • 72 (a)
(Pan troglodytes)
Mammalia PLA2G2F 35
  • 98.1 (n)
  • 96.21 (a)
PLA2G2F 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Pla2g2f 35
  • 80.45 (n)
  • 73.56 (a)
(Monodelphis domestica)
Mammalia PLA2G2F 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia PLA2G2F 36
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
Species with no ortholog for PLA2G2F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2F Gene

Gene Tree for PLA2G2F (if available)
Gene Tree for PLA2G2F (if available)

Paralogs for PLA2G2F Gene

(7) SIMAP similar genes for PLA2G2F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLA2G2F: view

Variants for PLA2G2F Gene

Sequence variations from dbSNP and Humsavar for PLA2G2F Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs518588 -- 20,138,951(-) aaagc(A/G)ggaat upstream-variant-2KB
rs523506 -- 20,147,670(+) gtctc(A/C)aactc intron-variant
rs528290 -- 20,141,655(+) CAGGG(C/G)CAGAT intron-variant
rs631134 -- 20,138,398(-) CTCAC(C/T)GAATG upstream-variant-2KB
rs818571 -- 20,149,898(-) AGTCC(A/G)GGCGG downstream-variant-500B, reference, missense, utr-variant-3-prime

Variation tolerance for PLA2G2F Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PLA2G2F Gene

Disorders for PLA2G2F Gene

Relevant External Links for PLA2G2F

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLA2G2F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G2F Gene

Publications for PLA2G2F Gene

  1. Cloning and recombinant expression of human group IIF-secreted phospholipase A(2). (PMID: 11112443) Valentin E. … Lambeau G. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 67
  2. Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2. (PMID: 11877435) Murakami M. … Kudo I. (J. Biol. Chem. 2002) 3 23
  3. sPLA2 and the epidermal barrier. (PMID: 24269828) Ilic D. … Mauro T.M. (Biochim. Biophys. Acta 2014) 3
  4. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3

Products for PLA2G2F Gene

Sources for PLA2G2F Gene