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Aliases for PLA2G2F Gene

Aliases for PLA2G2F Gene

  • Phospholipase A2, Group IIF 2 3
  • Phosphatidylcholine 2-Acylhydrolase 2F 3 4
  • GIIF SPLA2 3 4
  • SPLA2-IIF 3 4
  • EC 3.1.1.4 4

External Ids for PLA2G2F Gene

Previous GeneCards Identifiers for PLA2G2F Gene

  • GC01P020037
  • GC01P019500
  • GC01P019611
  • GC01P019935
  • GC01P020211
  • GC01P020338
  • GC01P020465
  • GC01P018711

Summaries for PLA2G2F Gene

GeneCards Summary for PLA2G2F Gene

PLA2G2F (Phospholipase A2, Group IIF) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot for PLA2G2F Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.

Tocris Summary for PLA2G2F Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2F Gene

Genomics for PLA2G2F Gene

Regulatory Elements for PLA2G2F Gene

Genomic Location for PLA2G2F Gene

Chromosome:
1
Start:
20,139,326 bp from pter
End:
20,150,386 bp from pter
Size:
11,061 bases
Orientation:
Plus strand

Genomic View for PLA2G2F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2G2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2F Gene

Proteins for PLA2G2F Gene

  • Protein details for PLA2G2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM2-PA2GF_HUMAN
    Recommended name:
    Group IIF secretory phospholipase A2
    Protein Accession:
    Q9BZM2
    Secondary Accessions:
    • Q5R385
    • Q8N217
    • Q9H506

    Protein attributes for PLA2G2F Gene

    Size:
    168 amino acids
    Molecular mass:
    18658 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G2F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G2F Gene

Proteomics data for PLA2G2F Gene at MOPED

Post-translational modifications for PLA2G2F Gene

  • Glycosylation at Asn 92, Asn 102, Asn 123, and Asn 144
  • Modification sites at PhosphoSitePlus

Other Protein References for PLA2G2F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G2F Gene

Domains & Families for PLA2G2F Gene

Gene Families for PLA2G2F Gene

Protein Domains for PLA2G2F Gene

Suggested Antigen Peptide Sequences for PLA2G2F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZM2

UniProtKB/Swiss-Prot:

PA2GF_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2F: view

Function for PLA2G2F Gene

Molecular function for PLA2G2F Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.

Enzyme Numbers (IUBMB) for PLA2G2F Gene

Gene Ontology (GO) - Molecular Function for PLA2G2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity NAS 11112443
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G2F: view

Phenotypes for PLA2G2F Gene

genes like me logo Genes that share phenotypes with PLA2G2F: view

Animal Models for PLA2G2F Gene

MGI Knock Outs for PLA2G2F:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for PLA2G2F Gene

Localization for PLA2G2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2F Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G2F Gene COMPARTMENTS Subcellular localization image for PLA2G2F gene
Compartment Confidence
extracellular 5
cytosol 4

Gene Ontology (GO) - Cellular Components for PLA2G2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PLA2G2F: view

Pathways & Interactions for PLA2G2F Gene

genes like me logo Genes that share pathways with PLA2G2F: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for PLA2G2F Gene

Gene Ontology (GO) - Biological Process for PLA2G2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0016042 lipid catabolic process IEA --
GO:0036148 phosphatidylglycerol acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with PLA2G2F: view

No data available for SIGNOR curated interactions for PLA2G2F Gene

Drugs & Compounds for PLA2G2F Gene

(9) Drugs for PLA2G2F Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(47) Additional Compounds for PLA2G2F Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
genes like me logo Genes that share compounds with PLA2G2F: view

Transcripts for PLA2G2F Gene

mRNA/cDNA for PLA2G2F Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G2F Gene

Phospholipase A2, group IIF:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2F Gene

No ASD Table

Relevant External Links for PLA2G2F Gene

GeneLoc Exon Structure for
PLA2G2F
ECgene alternative splicing isoforms for
PLA2G2F

Expression for PLA2G2F Gene

mRNA expression in normal human tissues for PLA2G2F Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G2F Gene

This gene is overexpressed in Bladder (x20.3), Skin - Not Sun Exposed (Suprapubic) (x15.9), and Skin - Sun Exposed (Lower leg) (x15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G2F Gene



SOURCE GeneReport for Unigene cluster for PLA2G2F Gene Hs.302034

mRNA Expression by UniProt/SwissProt for PLA2G2F Gene

Q9BZM2-PA2GF_HUMAN
Tissue specificity: Expressed at high levels in placenta, testis, thymus and at lower levels in heart, kidney, liver and prostate.
genes like me logo Genes that share expression patterns with PLA2G2F: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for PLA2G2F Gene

Orthologs for PLA2G2F Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2F Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2G2F 35
  • 82.9 (n)
  • 75.13 (a)
PLA2G2F 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G2F 35
  • 83.17 (n)
  • 75.71 (a)
PLA2G2F 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g2f 35
  • 80.45 (n)
  • 72.6 (a)
Pla2g2f 16
Pla2g2f 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G2F 35
  • 98.1 (n)
  • 96.21 (a)
PLA2G2F 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g2f 35
  • 80.45 (n)
  • 73.56 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA2G2F 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G2F 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
OneToMany
Species with no ortholog for PLA2G2F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2F Gene

ENSEMBL:
Gene Tree for PLA2G2F (if available)
TreeFam:
Gene Tree for PLA2G2F (if available)

Paralogs for PLA2G2F Gene

Paralogs for PLA2G2F Gene

(7) SIMAP similar genes for PLA2G2F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLA2G2F: view

Variants for PLA2G2F Gene

Sequence variations from dbSNP and Humsavar for PLA2G2F Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs518588 -- 20,138,951(-) aaagc(A/G)ggaat upstream-variant-2KB
rs523506 -- 20,147,670(+) gtctc(A/C)aactc intron-variant
rs528290 -- 20,141,654(+) AGGGC(C/G)AGATG intron-variant
rs631134 -- 20,138,398(-) CTCAC(C/T)GAATG upstream-variant-2KB
rs818571 -- 20,149,898(-) AGTCC(A/G)GGCGG utr-variant-3-prime, reference, missense, downstream-variant-500B

Variation tolerance for PLA2G2F Gene

Residual Variation Intolerance Score: 71.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G2F Gene

HapMap Linkage Disequilibrium report
PLA2G2F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLA2G2F Gene

Disorders for PLA2G2F Gene

Relevant External Links for PLA2G2F

Genetic Association Database (GAD)
PLA2G2F
Human Genome Epidemiology (HuGE) Navigator
PLA2G2F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G2F
genes like me logo Genes that share disorders with PLA2G2F: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G2F Gene

Publications for PLA2G2F Gene

  1. Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2. (PMID: 11877435) Murakami M. … Kudo I. (J. Biol. Chem. 2002) 23 67
  2. Cloning and recombinant expression of human group IIF-secreted phospholipase A(2). (PMID: 11112443) Valentin E. … Lambeau G. (Biochem. Biophys. Res. Commun. 2000) 2 67
  3. sPLA2 and the epidermal barrier. (PMID: 24269828) Ilic D. … Mauro T.M. (Biochim. Biophys. Acta 2014) 67
  4. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 67
  5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 67

Products for PLA2G2F Gene

Sources for PLA2G2F Gene

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