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Aliases for PLA2G2E Gene

Aliases for PLA2G2E Gene

  • Phospholipase A2 Group IIE 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 2E 3 4
  • GIIE SPLA2 3 4
  • SPLA2-IIE 3 4
  • Group IIE Secretory Phospholipase A2 3
  • Phospholipase A2, Group IIE 2
  • EC 3.1.1.4 4

External Ids for PLA2G2E Gene

Previous GeneCards Identifiers for PLA2G2E Gene

  • GC01M019816
  • GC01M019281
  • GC01M019392
  • GC01M019716
  • GC01M019992
  • GC01M020119
  • GC01M020247
  • GC01M018492

Summaries for PLA2G2E Gene

GeneCards Summary for PLA2G2E Gene

PLA2G2E (Phospholipase A2 Group IIE) is a Protein Coding gene. Among its related pathways are Linoleic acid metabolism and Vascular smooth muscle contraction. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2A.

UniProtKB/Swiss-Prot for PLA2G2E Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Tocris Summary for PLA2G2E Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2E Gene

Genomics for PLA2G2E Gene

Regulatory Elements for PLA2G2E Gene

Enhancers for PLA2G2E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G019974 1.2 Ensembl ENCODE 11.4 -51.6 -51646 1.8 FOXA2 MLX ARID4B SIN3A YY1 TCF12 GATA2 ZNF416 ZNF143 ZNF263 OTUD3 PLA2G2E EMC1 PLA2G2A NBL1 RN7SL304P
GH01G019474 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5 +446.4 446369 5.2 HDAC1 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 NFXL1 TCF12 ZNF121 GATA2 AKR7A2 CAPZB PLA2G2E UBR4 TMCO4 PIR41915
GH01G019892 0.6 ENCODE 11.2 +30.8 30847 1.3 CBX8 JUND JUN CEBPG FOS TRIM24 SPI1 OTUD3 PLA2G2E CAMK2N1 LOC105376823 PIR55587
GH01G019432 2 FANTOM5 Ensembl ENCODE dbSUPER 2.4 +471.8 471776 39.4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 MEF2D SSRP1 RCOR2 CAPZB NBL1 OTUD3 RNU4-28P EMC1 HTR6 AKR7A2 AKR7A3 PQLC2 UBR4
GH01G019925 1.2 ENCODE dbSUPER 0.7 -2.1 -2136 1.0 ELF3 ATF1 MLX ARID4B RAD21 THRB ZNF48 ZSCAN9 RARA GATA4 PLA2G2E RN7SL304P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLA2G2E on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G2E Gene

Chromosome:
1
Start:
19,920,009 bp from pter
End:
19,923,617 bp from pter
Size:
3,609 bases
Orientation:
Minus strand

Genomic View for PLA2G2E Gene

Genes around PLA2G2E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2E Gene

Proteins for PLA2G2E Gene

  • Protein details for PLA2G2E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZK7-PA2GE_HUMAN
    Recommended name:
    Group IIE secretory phospholipase A2
    Protein Accession:
    Q9NZK7
    Secondary Accessions:
    • Q5VXJ8

    Protein attributes for PLA2G2E Gene

    Size:
    142 amino acids
    Molecular mass:
    15989 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLA2G2E Gene

Post-translational modifications for PLA2G2E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G2E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G2E Gene

Domains & Families for PLA2G2E Gene

Gene Families for PLA2G2E Gene

Protein Domains for PLA2G2E Gene

Suggested Antigen Peptide Sequences for PLA2G2E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZK7

UniProtKB/Swiss-Prot:

PA2GE_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2E: view

Function for PLA2G2E Gene

Molecular function for PLA2G2E Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Enzyme Numbers (IUBMB) for PLA2G2E Gene

Gene Ontology (GO) - Molecular Function for PLA2G2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G2E: view
genes like me logo Genes that share phenotypes with PLA2G2E: view

Animal Models for PLA2G2E Gene

MGI Knock Outs for PLA2G2E:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G2E

miRNA for PLA2G2E Gene

miRTarBase miRNAs that target PLA2G2E

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G2E Gene

Localization for PLA2G2E Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2E Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G2E gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PLA2G2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PLA2G2E: view

Pathways & Interactions for PLA2G2E Gene

genes like me logo Genes that share pathways with PLA2G2E: view

Gene Ontology (GO) - Biological Process for PLA2G2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 10681567
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006954 inflammatory response TAS 10681567
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G2E: view

No data available for SIGNOR curated interactions for PLA2G2E Gene

Drugs & Compounds for PLA2G2E Gene

(25) Drugs for PLA2G2E Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aminosalicylic Acid Approved Pharma Target, unknown 30
Glycerol Approved, Experimental Pharma Target 238
Nimesulide Approved, Withdrawn Pharma Target Non-steroidal anti-inflammatory drug 10
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0

(45) Additional Compounds for PLA2G2E Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G2E Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
U 73343 Analog of U 73122 (Cat. No. 1268) 142878-12-4
VU 0155069 Potent and selective PLD1 inhibitor 1130067-06-9
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor 1244640-48-9
genes like me logo Genes that share compounds with PLA2G2E: view

Transcripts for PLA2G2E Gene

mRNA/cDNA for PLA2G2E Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2E Gene

No ASD Table

Relevant External Links for PLA2G2E Gene

GeneLoc Exon Structure for
PLA2G2E
ECgene alternative splicing isoforms for
PLA2G2E

Expression for PLA2G2E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G2E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G2E Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x43.9) and Skin - Sun Exposed (Lower leg) (x4.3).

Protein differential expression in normal tissues from HIPED for PLA2G2E Gene

This gene is overexpressed in Hair follicle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G2E Gene



Protein tissue co-expression partners for PLA2G2E Gene

NURSA nuclear receptor signaling pathways regulating expression of PLA2G2E Gene:

PLA2G2E

SOURCE GeneReport for Unigene cluster for PLA2G2E Gene:

Hs.272372

mRNA Expression by UniProt/SwissProt for PLA2G2E Gene:

Q9NZK7-PA2GE_HUMAN
Tissue specificity: Restricted to the brain, heart, lung, and placenta.
genes like me logo Genes that share expression patterns with PLA2G2E: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G2E Gene

Orthologs for PLA2G2E Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G2E 34 35
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia PLA2G2E 34 35
  • 86.38 (n)
dog
(Canis familiaris)
Mammalia PLA2G2E 34 35
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Pla2g2e 34 16 35
  • 81.92 (n)
oppossum
(Monodelphis domestica)
Mammalia PLA2G2E 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G2E 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G2E 34 35
  • 60.1 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496855 34
  • 51.63 (n)
Species where no ortholog for PLA2G2E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2E Gene

ENSEMBL:
Gene Tree for PLA2G2E (if available)
TreeFam:
Gene Tree for PLA2G2E (if available)

Paralogs for PLA2G2E Gene

(8) SIMAP similar genes for PLA2G2E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLA2G2E: view

Variants for PLA2G2E Gene

Sequence variations from dbSNP and Humsavar for PLA2G2E Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000932949 -- 19,923,178(+) TTCCC(A/G)GTGCT intron-variant
rs1001054964 -- 19,920,775(+) CTAGG(C/T)AACCC intron-variant
rs1001180617 -- 19,923,280(+) CATCC(A/G)GGAAG intron-variant
rs1001436590 -- 19,922,713(+) TCTCG(-/ATC)ATCAC cds-indel
rs1002943569 -- 19,920,770(+) GATTT(C/T)TAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2E Gene

Variant ID Type Subtype PubMed ID
nsv460717 CNV loss 19166990
nsv545730 CNV loss 21841781

Variation tolerance for PLA2G2E Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G2E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G2E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G2E Gene

Disorders for PLA2G2E Gene

Relevant External Links for PLA2G2E

Genetic Association Database (GAD)
PLA2G2E
Human Genome Epidemiology (HuGE) Navigator
PLA2G2E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G2E

No disorders were found for PLA2G2E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G2E Gene

Publications for PLA2G2E Gene

  1. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. (PMID: 10681567) Suzuki N. … Hanasaki K. (J. Biol. Chem. 2000) 2 3 4 64
  2. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 46 64
  3. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern D.P. … Seielstad M. (Nat. Genet. 2010) 3 46 64
  4. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PMID: 19122664) Silverberg M.S. … Duerr R.H. (Nat. Genet. 2009) 3 46 64
  5. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. (PMID: 19915572) . … Strachan D.P. (Nat. Genet. 2009) 3 46 64

Products for PLA2G2E Gene

Sources for PLA2G2E Gene

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