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Aliases for PLA2G2E Gene

Aliases for PLA2G2E Gene

  • Phospholipase A2 Group IIE 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 2E 3 4
  • Phospholipase A2, Group IIE 2 3
  • GIIE SPLA2 3 4
  • SPLA2-IIE 3 4
  • EC 4

External Ids for PLA2G2E Gene

Previous GeneCards Identifiers for PLA2G2E Gene

  • GC01M019816
  • GC01M019281
  • GC01M019392
  • GC01M019716
  • GC01M019992
  • GC01M020119
  • GC01M020247
  • GC01M018492

Summaries for PLA2G2E Gene

GeneCards Summary for PLA2G2E Gene

PLA2G2E (Phospholipase A2 Group IIE) is a Protein Coding gene. Among its related pathways are Linoleic acid metabolism and Pancreatic secretion. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2C.

UniProtKB/Swiss-Prot for PLA2G2E Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Tocris Summary for PLA2G2E Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2E Gene

Genomics for PLA2G2E Gene

Regulatory Elements for PLA2G2E Gene

Enhancers for PLA2G2E Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLA2G2E on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G2E Gene

19,920,009 bp from pter
19,923,617 bp from pter
3,609 bases
Minus strand

Genomic View for PLA2G2E Gene

Genes around PLA2G2E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2E Gene

Proteins for PLA2G2E Gene

  • Protein details for PLA2G2E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Group IIE secretory phospholipase A2
    Protein Accession:
    Secondary Accessions:
    • Q5VXJ8

    Protein attributes for PLA2G2E Gene

    142 amino acids
    Molecular mass:
    15989 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLA2G2E Gene

Proteomics data for PLA2G2E Gene at MOPED

Post-translational modifications for PLA2G2E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G2E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G2E Gene

Domains & Families for PLA2G2E Gene

Gene Families for PLA2G2E Gene

Protein Domains for PLA2G2E Gene

Suggested Antigen Peptide Sequences for PLA2G2E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phospholipase A2 family.
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2E: view

Function for PLA2G2E Gene

Molecular function for PLA2G2E Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Enzyme Numbers (IUBMB) for PLA2G2E Gene

genes like me logo Genes that share phenotypes with PLA2G2E: view

Animal Models for PLA2G2E Gene

MGI Knock Outs for PLA2G2E:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G2E

miRNA for PLA2G2E Gene

miRTarBase miRNAs that target PLA2G2E

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G2E Gene

Localization for PLA2G2E Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2E Gene


Subcellular locations from

Jensen Localization Image for PLA2G2E Gene COMPARTMENTS Subcellular localization image for PLA2G2E gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for PLA2G2E Gene

Pathways & Interactions for PLA2G2E Gene

genes like me logo Genes that share pathways with PLA2G2E: view

Interacting Proteins for PLA2G2E Gene

Gene Ontology (GO) - Biological Process for PLA2G2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA,TAS 10681567
GO:0006954 inflammatory response TAS 10681567
GO:0016042 lipid catabolic process IEA --
GO:0036149 phosphatidylinositol acyl-chain remodeling TAS --
GO:0036150 phosphatidylserine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with PLA2G2E: view

No data available for SIGNOR curated interactions for PLA2G2E Gene

Drugs & Compounds for PLA2G2E Gene

(23) Drugs for PLA2G2E Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aminosalicylic Acid Approved Pharma Target, unknown 27
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
Glycerol Experimental Pharma Target 205
Tridecanoic acid Experimental Pharma Target 0

(47) Additional Compounds for PLA2G2E Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G2E Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G2E: view

Transcripts for PLA2G2E Gene

mRNA/cDNA for PLA2G2E Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2E Gene

No ASD Table

Relevant External Links for PLA2G2E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLA2G2E Gene

mRNA expression in normal human tissues for PLA2G2E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G2E Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x43.9) and Skin - Sun Exposed (Lower leg) (x4.3).

Protein differential expression in normal tissues from HIPED for PLA2G2E Gene

This gene is overexpressed in Hair follicle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G2E Gene

SOURCE GeneReport for Unigene cluster for PLA2G2E Gene Hs.272372

mRNA Expression by UniProt/SwissProt for PLA2G2E Gene

Tissue specificity: Restricted to the brain, heart, lung, and placenta.
genes like me logo Genes that share expression patterns with PLA2G2E: view

Protein tissue co-expression partners for PLA2G2E Gene

Primer Products

Orthologs for PLA2G2E Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2E Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLA2G2E 35
  • 86.38 (n)
  • 85.21 (a)
PLA2G2E 36
  • 85 (a)
(Canis familiaris)
Mammalia PLA2G2E 35
  • 83.33 (n)
  • 79.58 (a)
PLA2G2E 36
  • 80 (a)
(Mus musculus)
Mammalia Pla2g2e 35
  • 81.92 (n)
  • 84.51 (a)
Pla2g2e 16
Pla2g2e 36
  • 85 (a)
(Pan troglodytes)
Mammalia PLA2G2E 35
  • 98.59 (n)
  • 97.89 (a)
PLA2G2E 36
  • 98 (a)
(Monodelphis domestica)
Mammalia PLA2G2E 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia PLA2G2E 36
  • 69 (a)
(Gallus gallus)
Aves PLA2G2E 35
  • 60.1 (n)
  • 54.01 (a)
PLA2G2E 36
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496855 35
  • 51.63 (n)
  • 41.35 (a)
Species with no ortholog for PLA2G2E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2E Gene

Gene Tree for PLA2G2E (if available)
Gene Tree for PLA2G2E (if available)

Paralogs for PLA2G2E Gene

(8) SIMAP similar genes for PLA2G2E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLA2G2E: view

Variants for PLA2G2E Gene

Sequence variations from dbSNP and Humsavar for PLA2G2E Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs877064 -- 19,923,017(-) TGACA(C/T)TGTAG intron-variant
rs818965 -- 19,924,032(+) CACCC(A/G)GGCAG upstream-variant-2KB
rs1108972 -- 19,922,153(+) GTTAC(A/G)TGGTA intron-variant
rs1108973 -- 19,922,158(+) GTGGT(A/G)ACGGG intron-variant
rs1108974 -- 19,922,216(+) TCACC(A/G)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2E Gene

Variant ID Type Subtype PubMed ID
nsv460717 CNV Loss 19166990

Variation tolerance for PLA2G2E Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PLA2G2E Gene

Disorders for PLA2G2E Gene

Relevant External Links for PLA2G2E

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PLA2G2E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G2E Gene

Publications for PLA2G2E Gene

  1. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. (PMID: 10681567) Suzuki N. … Hanasaki K. (J. Biol. Chem. 2000) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Arachidonate release and eicosanoid generation by group IIE phospholipase A(2). (PMID: 11922621) Murakami M. … Kudo I. (Biochem. Biophys. Res. Commun. 2002) 2 3
  5. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26

Products for PLA2G2E Gene

Sources for PLA2G2E Gene