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Aliases for PLA2G2D Gene

Aliases for PLA2G2D Gene

  • Phospholipase A2 Group IID 2 3 5
  • Secretory-Type PLA, Stroma-Associated Homolog 3 4
  • Phosphatidylcholine 2-Acylhydrolase 2D 3 4
  • Phospholipase A2, Group IID 2 3
  • GIID SPLA2 3 4
  • SPLA2-IID 3 4
  • PLA2IID 3 4
  • SPLASH 3 4
  • Secretory Phospholipase A2s 3
  • EC 3.1.1.4 4
  • SPLA2S 3

External Ids for PLA2G2D Gene

Previous GeneCards Identifiers for PLA2G2D Gene

  • GC01M020008
  • GC01M019473
  • GC01M019718
  • GC01M019907
  • GC01M020183
  • GC01M020311
  • GC01M020438
  • GC01M018684

Summaries for PLA2G2D Gene

Entrez Gene Summary for PLA2G2D Gene

  • This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

GeneCards Summary for PLA2G2D Gene

PLA2G2D (Phospholipase A2 Group IID) is a Protein Coding gene. Diseases associated with PLA2G2D include bladder diverticulum and splenic infarction. Among its related pathways are Linoleic acid metabolism and Acyl chain remodelling of PC. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2C.

UniProtKB/Swiss-Prot for PLA2G2D Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.

Tocris Summary for PLA2G2D Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G2D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2D Gene

Genomics for PLA2G2D Gene

Regulatory Elements for PLA2G2D Gene

Enhancers for PLA2G2D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLA2G2D on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G2D Gene

Chromosome:
1
Start:
20,111,939 bp from pter
End:
20,119,566 bp from pter
Size:
7,628 bases
Orientation:
Minus strand

Genomic View for PLA2G2D Gene

Genes around PLA2G2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2D Gene

Proteins for PLA2G2D Gene

  • Protein details for PLA2G2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNK4-PA2GD_HUMAN
    Recommended name:
    Group IID secretory phospholipase A2
    Protein Accession:
    Q9UNK4
    Secondary Accessions:
    • A8K2Z1
    • B1AEL9
    • Q9UK01

    Protein attributes for PLA2G2D Gene

    Size:
    145 amino acids
    Molecular mass:
    16546 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLA2G2D Gene

Proteomics data for PLA2G2D Gene at MOPED

Post-translational modifications for PLA2G2D Gene

  • Glycosylation at Asn 89
  • Modification sites at PhosphoSitePlus

Other Protein References for PLA2G2D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G2D Gene

Domains & Families for PLA2G2D Gene

Gene Families for PLA2G2D Gene

Protein Domains for PLA2G2D Gene

Suggested Antigen Peptide Sequences for PLA2G2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNK4

UniProtKB/Swiss-Prot:

PA2GD_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2D: view

Function for PLA2G2D Gene

Molecular function for PLA2G2D Gene

GENATLAS Biochemistry:
phospholipase A2,group IID,secreted,predominantly expressed in the pancreas,spleen and less abundantly in the colon,thymus,placenta,small intestine and prostate,with several isoform putatively involved in inflammation and/or in the production of lipid mediators
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimally active at neutral to alkaline pHs with 2 mM Ca(2+).;
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.

Enzyme Numbers (IUBMB) for PLA2G2D Gene

genes like me logo Genes that share phenotypes with PLA2G2D: view

Animal Models for PLA2G2D Gene

MGI Knock Outs for PLA2G2D:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G2D

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G2D Gene

Localization for PLA2G2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2D Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G2D Gene COMPARTMENTS Subcellular localization image for PLA2G2D gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PLA2G2D Gene

Pathways & Interactions for PLA2G2D Gene

genes like me logo Genes that share pathways with PLA2G2D: view

Interacting Proteins for PLA2G2D Gene

Gene Ontology (GO) - Biological Process for PLA2G2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA --
GO:0006644 phospholipid metabolic process IEA,TAS 10455175
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0006954 inflammatory response TAS 10455175
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G2D: view

No data available for SIGNOR curated interactions for PLA2G2D Gene

Drugs & Compounds for PLA2G2D Gene

(12) Drugs for PLA2G2D Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clofazimine Approved, Investigational Pharma Tuberculosis drug 21
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
Stearic acid Experimental Pharma Target 0
arachidonic acid Experimental Nutra Activator 27
MYRISTIC ACID Experimental Pharma 0

(54) Additional Compounds for PLA2G2D Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Dodecanoic acid
  • 1-Undecanecarboxylate
  • 1-Undecanecarboxylic acid
  • ABL
  • Aliphat No. 4
  • Dodecanoate
143-07-7
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)

(5) Tocris Compounds for PLA2G2D Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7

(3) ApexBio Compounds for PLA2G2D Gene

Compound Action Cas Number
Clofazimine Tuberculosis drug 2030-63-9
CP-91149 Selective inhibitor of glycogen phosphorylase 186392-40-5
Varespladib (LY315920) HnsPLA inhibitor,potent and selective 172732-68-2
genes like me logo Genes that share compounds with PLA2G2D: view

Transcripts for PLA2G2D Gene

mRNA/cDNA for PLA2G2D Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G2D Gene

Phospholipase A2, group IID:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for PLA2G2D Gene

GeneLoc Exon Structure for
PLA2G2D
ECgene alternative splicing isoforms for
PLA2G2D

Expression for PLA2G2D Gene

mRNA expression in normal human tissues for PLA2G2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G2D Gene

This gene is overexpressed in Spleen (x22.8) and Small Intestine - Terminal Ileum (x11.5).

SOURCE GeneReport for Unigene cluster for PLA2G2D Gene Hs.189507

mRNA Expression by UniProt/SwissProt for PLA2G2D Gene

Q9UNK4-PA2GD_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with PLA2G2D: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PLA2G2D Gene

Orthologs for PLA2G2D Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2D Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PLA2G2D 35
  • 83.68 (n)
  • 75.17 (a)
PLA2G2D 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g2d 35
  • 79.63 (n)
  • 71.53 (a)
Pla2g2d 16
Pla2g2d 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G2D 35
  • 99.54 (n)
  • 98.62 (a)
PLA2G2D 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g2d 35
  • 78.7 (n)
  • 70.14 (a)
cow
(Bos Taurus)
Mammalia PLA2G2D3 36
  • 58 (a)
OneToMany
PLA2G2D4 36
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PLA2G2D 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G2D 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
Species with no ortholog for PLA2G2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2D Gene

ENSEMBL:
Gene Tree for PLA2G2D (if available)
TreeFam:
Gene Tree for PLA2G2D (if available)

Paralogs for PLA2G2D Gene

(7) SIMAP similar genes for PLA2G2D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLA2G2D: view

Variants for PLA2G2D Gene

Sequence variations from dbSNP and Humsavar for PLA2G2D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs584367 - 20,115,561(+) GATGC(C/T)GCACC intron-variant, reference, missense
rs62541890 - 20,115,604(-) TGCCA(G/T)ACCCA intron-variant, reference, missense
rs62541891 - 20,115,581(-) TGACC(A/G)CCTGA intron-variant, reference, missense
rs62541892 - 20,115,512(-) CATCC(A/G)CTGCT intron-variant, reference, missense
rs62541900 - 20,114,191(-) TGAAG(C/G/T)GCAAC reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2D Gene

Variant ID Type Subtype PubMed ID
nsv5520 CNV Loss 18451855
esv1003821 CNV Deletion 20482838

Variation tolerance for PLA2G2D Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G2D Gene

HapMap Linkage Disequilibrium report
PLA2G2D
Human Gene Mutation Database (HGMD)
PLA2G2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G2D Gene

Disorders for PLA2G2D Gene

MalaCards: The human disease database

(4) MalaCards diseases for PLA2G2D Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bladder diverticulum
  • diverticulum - bladder
splenic infarction
  • splenic infarct
hemopneumothorax
surfactant dysfunction
  • pulmonary surfactant metabolism dysfunction
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2G2D

Genetic Association Database (GAD)
PLA2G2D
Human Genome Epidemiology (HuGE) Navigator
PLA2G2D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G2D
genes like me logo Genes that share disorders with PLA2G2D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G2D Gene

Publications for PLA2G2D Gene

  1. Cloning and characterization of novel mouse and human secretory phospholipase A2s. (PMID: 10455175) Ishizaki J. … Hanasaki K. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Gly80Ser polymorphism of phospholipase A2-IID is associated with cytokine inducibility in A549 cells. (PMID: 19365107) Igarashi A. … Kubota I. (Respiration 2009) 3 23
  3. Biochemistry and physiology of mammalian secreted phospholipases A2. (PMID: 18405237) Lambeau G. … Gelb M.H. (Annu. Rev. Biochem. 2008) 3 23
  4. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  5. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26

Products for PLA2G2D Gene

Sources for PLA2G2D Gene

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