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Aliases for PLA2G2C Gene

Aliases for PLA2G2C Gene

  • Phospholipase A2 Group IIC 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase-Like Protein GIIC 4
  • Phospholipase A2, Group IIC (Possible Pseudogene) 2
  • Phospholipase A2, Group IIC 2

External Ids for PLA2G2C Gene

Previous GeneCards Identifiers for PLA2G2C Gene

  • GC01U990213
  • GC01M019959
  • GC01M020349
  • GC01M020489
  • GC01M018736

Summaries for PLA2G2C Gene

GeneCards Summary for PLA2G2C Gene

PLA2G2C (Phospholipase A2 Group IIC) is a Protein Coding gene. Among its related pathways are Oxytocin signaling pathway and Linoleic acid metabolism. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PLA2G2F.

UniProtKB/Swiss-Prot for PLA2G2C Gene

  • Inactive phospholipase.

Tocris Summary for PLA2G2C Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2C Gene

Genomics for PLA2G2C Gene

Regulatory Elements for PLA2G2C Gene

Enhancers for PLA2G2C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F020109 1.1 FANTOM5 ENCODE 10.8 +66.8 66780 1.7 GATA3 JUND ATF3 JUN BHLHE40 FOS PLA2G2F PLA2G2C MUL1 UBXN10 NBL1 PLA2G2D LOC100419911
GH01F020110 1.1 ENCODE 10.8 +67.8 67840 0.1 CTCF FOS PLA2G2F PLA2G2C PLA2G2D LOC100419911
GH01F020093 0.4 ENCODE 10.7 +83.4 83362 0.2 HLF KLF9 CEBPB PLA2G2D PLA2G2F PLA2G2C ENSG00000226664 LOC100419911
GH01F020101 0.7 Ensembl ENCODE 10.7 +76.2 76224 0.4 SCRT1 CTCF ZNF654 ZNF175 MAX TRIM22 REST RAD21 SCRT2 SMC3 PLA2G2F PLA2G2C ENSG00000226664 NBL1 PLA2G2D LOC100419911
GH01F020058 1.3 Ensembl ENCODE 10 +117.8 117824 3.2 RFX1 MTA2 BMI1 TBX21 ZNF623 GABPA NR2F2 EED IKZF1 ZNF24 PLA2G5 PLA2G2C LOC100419911 PLA2G2D
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PLA2G2C on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G2C Gene

Chromosome:
1
Start:
20,161,253 bp from pter
End:
20,177,424 bp from pter
Size:
16,172 bases
Orientation:
Minus strand

Genomic View for PLA2G2C Gene

Genes around PLA2G2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2C Gene

Proteins for PLA2G2C Gene

  • Protein details for PLA2G2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5R387-PA2GC_HUMAN
    Recommended name:
    Putative inactive group IIC secretory phospholipase A2
    Protein Accession:
    Q5R387
    Secondary Accessions:
    • Q7M4M6

    Protein attributes for PLA2G2C Gene

    Size:
    149 amino acids
    Molecular mass:
    16844 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI20258.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PLA2G2C Gene

Post-translational modifications for PLA2G2C Gene

No Post-translational modifications

Other Protein References for PLA2G2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G2C Gene

Domains & Families for PLA2G2C Gene

Gene Families for PLA2G2C Gene

Protein Domains for PLA2G2C Gene

Suggested Antigen Peptide Sequences for PLA2G2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5R387

UniProtKB/Swiss-Prot:

PA2GC_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2C: view

Function for PLA2G2C Gene

Molecular function for PLA2G2C Gene

GENATLAS Biochemistry:
phospholipase A2,group IIC,Ca2+ dependent,non pancreatic,secreted,likely pseudogene
UniProtKB/Swiss-Prot Function:
Inactive phospholipase.

Gene Ontology (GO) - Molecular Function for PLA2G2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G2C: view
genes like me logo Genes that share phenotypes with PLA2G2C: view

Animal Model Products

miRNA for PLA2G2C Gene

miRTarBase miRNAs that target PLA2G2C

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G2C Gene

Localization for PLA2G2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2C Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G2C Gene COMPARTMENTS Subcellular localization image for PLA2G2C gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PLA2G2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLA2G2C: view

Pathways & Interactions for PLA2G2C Gene

genes like me logo Genes that share pathways with PLA2G2C: view

Interacting Proteins for PLA2G2C Gene

Gene Ontology (GO) - Biological Process for PLA2G2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0050482 arachidonic acid secretion IEA --
genes like me logo Genes that share ontologies with PLA2G2C: view

No data available for SIGNOR curated interactions for PLA2G2C Gene

Drugs & Compounds for PLA2G2C Gene

(4) Drugs for PLA2G2C Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D609 Pharma PC-PLC inhibitor, Selective PC-PLC inhibitor 0
U 73343 Pharma Analog of U 73122 (Cat. No. 1268) 0
SPK-601 Pharma Potent PC-PLC inhibitor,antimicrobial agent 0
calcium Nutra 0

(7) Additional Compounds for PLA2G2C Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
88542-95-4
Phosphatidylcholines Group C
  • 1,2-Di(1-enyl-palmitoyl)-rac-glycero-3-phosphocholine
  • GPCho(16:0/16:0)
  • GPCho(32:0)
  • Lecithin
  • PC aa C32:0
m-3M3FBS
200933-14-8

(5) Tocris Compounds for PLA2G2C Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
U 73343 Analog of U 73122 (Cat. No. 1268) 142878-12-4
VU 0155069 Potent and selective PLD1 inhibitor 1130067-06-9
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor 1244640-48-9

(3) ApexBio Compounds for PLA2G2C Gene

Compound Action Cas Number
D609 PC-PLC inhibitor 83373-60-8
SPK-601 Potent PC-PLC inhibitor,antimicrobial agent 1096687-52-3
U 73343 142878-12-4
genes like me logo Genes that share compounds with PLA2G2C: view

Transcripts for PLA2G2C Gene

mRNA/cDNA for PLA2G2C Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G2C Gene

Phospholipase A2, group IIC:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2C Gene

No ASD Table

Relevant External Links for PLA2G2C Gene

GeneLoc Exon Structure for
PLA2G2C
ECgene alternative splicing isoforms for
PLA2G2C

Expression for PLA2G2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G2C Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G2C Gene

This gene is overexpressed in Colon - Sigmoid (x14.9) and Esophagus - Muscularis (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of PLA2G2C Gene:

PLA2G2C

SOURCE GeneReport for Unigene cluster for PLA2G2C Gene:

Hs.512512
genes like me logo Genes that share expression patterns with PLA2G2C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PLA2G2C Gene

Orthologs for PLA2G2C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G2C 35
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLA2G2C 34 35
  • 76.92 (n)
mouse
(Mus musculus)
Mammalia Pla2g2c 34 16 35
  • 75.06 (n)
rat
(Rattus norvegicus)
Mammalia Pla2g2c 34
  • 73.7 (n)
dog
(Canis familiaris)
Mammalia PLA2G2C 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLA2G2C 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G2A 35
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
OneToMany
Species where no ortholog for PLA2G2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2C Gene

ENSEMBL:
Gene Tree for PLA2G2C (if available)
TreeFam:
Gene Tree for PLA2G2C (if available)

Paralogs for PLA2G2C Gene

(7) SIMAP similar genes for PLA2G2C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLA2G2C: view

Variants for PLA2G2C Gene

Sequence variations from dbSNP and Humsavar for PLA2G2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10710359 -- 20,171,779(+) TTTTT(-/T)GAGAC intron-variant
rs10753482 -- 20,164,807(+) TTTCA(C/T)GTCCG intron-variant
rs10753483 -- 20,177,217(+) TCTGC(A/G)GGACT intron-variant, upstream-variant-2KB
rs10799611 -- 20,166,658(+) CCTCT(C/G)TCTTC intron-variant
rs10799612 -- 20,176,268(+) GTAAA(C/G)GCTGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2C Gene

Variant ID Type Subtype PubMed ID
esv2380061 CNV deletion 18987734
esv2606339 CNV deletion 19546169
esv26309 CNV loss 19812545
esv26523 CNV loss 19812545
esv2674003 CNV deletion 23128226
esv2674305 CNV deletion 23128226
esv3553899 CNV deletion 23714750
esv3585415 CNV loss 21293372
esv3585416 CNV loss 21293372
esv3585417 CNV loss 21293372
nsv1122306 CNV deletion 24896259
nsv545731 CNV gain 21841781

Variation tolerance for PLA2G2C Gene

Gene Damage Index Score: 9.68; 89.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G2C Gene

Disorders for PLA2G2C Gene

Relevant External Links for PLA2G2C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G2C

No disorders were found for PLA2G2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G2C Gene

Publications for PLA2G2C Gene

  1. Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. (PMID: 8838795) Tischfield J.A. … Lusis A.J. (Genomics 1996) 2 3 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  3. Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. (PMID: 9745929) SchrAPder H.C. … MA1ller W.E. (Neurotoxicology 1998) 3 64
  4. HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes. (PMID: 9377118) Mavoungou E. … Russo-Marie F. (J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1997) 3 64
  5. Novel gene exon homologous to pancreatic phospholipase A2: sequence and chromosomal mapping of both human genes. (PMID: 2708461) Seilhamer J.J. … Lusis A.J. (J. Cell. Biochem. 1989) 4 64

Products for PLA2G2C Gene

Sources for PLA2G2C Gene

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