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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLA2G2A Gene

protein-coding GIFtS: 70
GCID: GC01M020301

phospholipase A2, group IIA (platelets, synovial fluid)

(Previous symbols: PLA2B, PLA2L)

Explore 108 diseases affiliated with
PLA2G2A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase A2, Group IIA (Platelets, Synovial Fluid)¹ ²		MOM1² ⁵
PLA2B¹ ² ³ ⁵		PLA2²
PLA2L¹ ² ³ ⁵		PLA2S²
Group IIA Phospholipase A2² ³		PLAS1²
Non-Pancreatic Secretory Phospholipase A2² ³		Phospholipase A2, Membrane Associated²
Phosphatidylcholine 2-Acylhydrolase 2A² ³		SPLA2¹
NPS-PLA2² ³		EC 3.1.1.4³
GIIC SPLA2² ³		RASF-A³

External Ids:	HGNC: 9031¹	Entrez Gene: 5320²	Ensembl: ENSG00000188257⁷	OMIM: 172411⁵	UniProtKB: P14555³

Export aliases for PLA2G2A gene to outside databases

Previous GC identifers: GC01M019872 GC01M019337 GC01M019717 GC01M019771 GC01M020047 GC01M020174 GC01M018547

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLA2G2A:

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family

of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product

belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and

requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of

phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of

the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs

have been found for this gene.(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: PA2GA_HUMAN, P14555

Function: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid

biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

summary for PLA2G2A:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which

cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates

lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+

concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including

roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLA2G2A gene promoter:
Nkx3-1 Nkx3-1 v4 Egr-1 Nkx3-1 v1 STAT5A MEF-2A Nkx3-1 v2 Chx10 Nkx3-1 v3 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PLA2G2A promoter sequence

Search SABiosciences Chromatin IP Primers for PLA2G2A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p35

PLA2G2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G2A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M020301: view genomic region (about GC identifiers)

Start:	20,301,924 bp from pter	End:	20,306,932 bp from pter
Size:	5,009 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PA2GA_HUMAN, P14555 (See protein sequence)

Recommended Name: Phospholipase A2, membrane associated precursor

Size: 144 amino acids; 16083 Da

Cofactor: Binds 1 calcium ion per subunit

Subcellular location: Membrane; Peripheral membrane protein

Miscellaneous: Group II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and

secreted forms are identical and are encoded by a single gene

6/17 PDB 3D structures from and Proteopedia for PLA2G2A (see all 17):

1AYP (3D)

1BBC (3D)

1DB4 (3D)

1DB5 (3D)

1DCY (3D)

1J1A (3D)

Secondary accessions: A8K5I7 Q6DN24 Q6IBD9 Q9UCD2

Explore the universe of human proteins at neXtProt for PLA2G2A: NX_P14555

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P14555

PLA2G2A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_000291.1 NP_001155199.1 NP_001155200.1 NP_001155201.1

ENSEMBL proteins:

ENSP00000364252 ENSP00000383364

Reactome Protein details: P14555
Human Recombinant Protein Products:

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	Uscn Proteins for PLA2G2A

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	17069818
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016020	membrane	--	--

PLA2G2A for ontologies About GeneDecksing

PLA2G2A Antibody Products:

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	Search ThermoFisher Antibodies for PLA2G2A

Assay Products for PLA2G2A:

	Browse Kits and Assays available from EMD Millipore
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	Uscn ELISAs and CLIAs for PLA2G2A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLA2G2A for domains About GeneDecksing

3 InterPro domains/families:

IPR016090 PLipase_A2

IPR001211 PLipase_A2_euk

IPR013090 PLipase_A2_AS

Graphical View of Domain Structure for InterPro Entry P14555

ProtoNet protein and cluster: P14555

1 Blocks protein family: IPB001211 Phospholipase A2

UniProtKB/Swiss-Prot: PA2GA_HUMAN, P14555

Similarity: Belongs to the phospholipase A2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PA2GA_HUMAN, P14555

Function: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid

biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate

Genatlas biochemistry entry for PLA2G2A:

phospholipase A2,group IIA,Ca2+ dependent,non pancreatic,secreted,expressed in platelets synovial fluid,potent mediator

of the inflammatory process,enhanced by inflammatory cytokines as well as lipolysaccharides in various cell

types,elevated in numerous inflammatory diseases including sepsis,Crohn disease and pancreatitis,deleted in

neuroblastoma,not involved in colorectal carcinoma,homolog to murine Mom1 (see also MOM1,TSG1C)

Enzyme Number (IUBMB): EC 3.1.1.4¹

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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PLA2G2A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G2A

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004623	phospholipase A2 activity	TAS	--
GO:0005509	calcium ion binding	IEA	--
GO:0005543	phospholipid binding	IDA	9032461
GO:0047498	calcium-dependent phospholipase A2 activity	TAS	9272153

PLA2G2A for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PLA2G2A:

Increased G1 DNA content

Synthetic lethal with Ras

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Pla2g2a):

tumorigenesis

PLA2G2A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Acyl chain remodelling of PE

8/9 pathways (see all 9)
Acyl chain remodelling of PE	1.00	phospholipases	0.39
Acyl chain remodelling of PC	0.85	Synthesis of PA	0.31
Acyl chain remodelling of PS	0.74	Anandamide biosynthesis and metabolism	0.13
Acyl chain remodelling of PI	0.62	Anandamide biosynthesis and metabolism	0.13

alpha-Linolenic acid metabolism

	alpha-Linolenic acid metabolism	1.00			Ether lipid metabolism	0.44
	Linoleic acid metabolism	0.52			Fat digestion and absorption	0.32

PEDF Induced Signaling

	MIF Mediated Glucocorticoid Regulation	0.73			all-trans-Retinoic Acid Signaling in Brain	0.59
	MIF Regulation of Innate Immune Cells	0.71			Endothelin-1 Signaling Pathway	0.44

Glycerophospholipid biosynthesis

	Glycerophospholipid biosynthesis	1.00			Glycerophospholipid metabolism	0.54
	Phospholipid metabolism	0.64

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for PLA2G2A

	Immune response CD16 signaling in NK cells
	Anandamide biosynthesis and metabolism

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLA2G2A (see all 13)

	Chemokine Signaling
	MIF Regulation of Innate Immune Cells
	DHA Signaling
	Endothelin-1 Signaling Pathway
	Antioxidant Action of Vitamin-C

2 GeneGo (Thomson Reuters) Pathways for PLA2G2A

	Anandamide biosynthesis and metabolism
	Immune response CD16 signaling in NK cells

4 BioSystems Pathways for PLA2G2A

	MicroRNAs in cardiomyocyte hypertrophy
	Eicosanoid Synthesis
	Glypican 1 network
	phospholipases

5/10 Reactome Pathways for PLA2G2A (see all 10)

	Acyl chain remodelling of PE
	Synthesis of PA
	Metabolism
	Acyl chain remodelling of PC
	Acyl chain remodelling of PG

2 PharmGKB Pathways for PLA2G2A

	Celecoxib Pathway, Pharmacodynamics
	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

5/16 Kegg Pathways (Kegg details for PLA2G2A) (see all 16):

	Glycerophospholipid metabolism
	Ether lipid metabolism
	Arachidonic acid metabolism
	Linoleic acid metabolism
	alpha-Linolenic acid metabolism

PLA2G2A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PLA2G2A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/107 Interacting proteins for PLA2G2A (P14555^{2, 3} ENSP00000364252⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 107)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CEP70	Q8NHQ1²^,³, ENSP00000264982⁴	MINT-8266733 I2D: score=2 STRING: ENSP00000264982
CRMP1	Q14194²^,³	MINT-63475 I2D: score=3
CRELD2	Q6UXH1²^,³	MINT-8266722 I2D: score=1
ALOX12	P18054²^,³, ENSP00000251535⁴	MINT-50574 I2D: score=2 STRING: ENSP00000251535
PLA2G1B	P04054³, ENSP00000312286⁴	I2D: score=3 STRING: ENSP00000312286

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006654	phosphatidic acid biosynthetic process	TAS	--
GO:0010744	positive regulation of macrophage derived foam cell differentiation	TAS	18827909
GO:0016042	lipid catabolic process	IEA	--
GO:0034374	low-density lipoprotein particle remodeling	TAS	18827909

PLA2G2A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PLA2G2A for compounds About GeneDecksing

EMD Millipore small molecules for PLA2G2A:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLA2G2A available from Tocris Bioscience About this table

Compound	Action	CAS #
RHC 80267	Diacylglycerol lipase inhibitor	[83654-05-1]
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
OBAA	Phospholipase A2 inhibitor	[221632-26-4]
PACOCF3	Phospholipase A2 inhibitor	[141022-99-3]

10/2140 HMDB Compounds for PLA2G2A (see all 2140) About this table

Compound	Synonyms	CAS #	PubMed Ids
PC(O-16:0/18:2(9Z,12Z))	1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)	88542-95-4	12486725
PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)	--	12486725
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)	103597-60-0	12486725
Alpha-Linolenic acid	(9,12,15)-linolenate (see all 23)	463-40-1	--
Arachidic acid	Arachate (see all 10)	506-30-9	--
Arachidonic acid	5,8,11,14-Eicosatetraenoic acid (see all 16)	506-32-1	--
Calcium	Ca (see all 2)	7440-70-2	--
Heptadecanoic acid	Heptadecanoate (see all 16)	506-12-7	--
Heptadecanoyl CoA	Heptadecanoyl coenzyme A (see all 19)	3546-17-6	--
Linoleic acid	(9Z,12Z)-9,12-Octadecadienoate (see all 26)	60-33-3	--

10/14 DrugBank Compounds for PLA2G2A (see all 14) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1,4-Butanediol	--	110-63-4	target	--	17139284 17016423 10592235
1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid	--	--	target	--	17139284 17016423 10592235
4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid	--	--	target	--	17139284 17016423 10592235
Diclofenac	Diclofenac Acid (see all 4)	15307-86-5	target	inhibitor	9279965 15906762 16552142
Elaidoylamide	--	--	target	--	17139284 17016423 10592235
Ginkgo biloba	Adiantifolia (see all 13)	--	target	inhibitor	10418340 10619176 16651744
[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid	--	--	target	--	17139284 17016423 10592235
(S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid	--	--	target	--	17139284 17016423
1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide	--	--	target	--	17139284 17016423
6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid	--	--	target	--	17139284 17016423

10/112 Novoseek chemical compound relationships for PLA2G2A gene (see all 112) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arachidonic acid	89.3	431	8636097 (5), 12813050 (5), 10657662 (5), 8555268 (4) (see all 99)
manoalide	86.5	23	8702436 (4), 8228253 (3), 9677277 (1), 10051149 (1) (see all 11)
scalaradial	85.9	13	17691073 (3), 8228253 (3), 10353635 (1), 8688196 (1) (see all 5)
ly311727	84.8	10	11934806 (2), 17069818 (1), 8764358 (1), 12829607 (1) (see all 7)
p-bromophenacyl bromide	84.3	44	2402761 (3), 8820966 (1), 9506985 (1), 11090064 (1) (see all 25)
aacocf3	83.7	31	8195210 (2), 11800413 (2), 12558054 (1), 15082220 (1) (see all 18)
bromoenol lactone	79.3	21	15082220 (1), 15474031 (1), 15950537 (1), 17537804 (1) (see all 13)
7,7-dimethyl-eicosadienoic acid	79.1	3	16645197 (1), 12688422 (1), 1906891 (1)
mafp	77.8	16	11641267 (1), 10026244 (1), 12039969 (1), 17374479 (1) (see all 8)
phospholipid	76.7	91	11159446 (3), 9154867 (2), 9180373 (2), 9692992 (2) (see all 68)

Search CenterWatch for drugs/clinical trials and news about PLA2G2A / PA2GA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLA2G2A gene (4 alternative transcripts):

NM_000300.3 NM_001161727.1 NM_001161728.1 NM_001161729.1

Unigene Cluster for PLA2G2A:

Phospholipase A2, group IIA (platelets, synovial fluid)

Hs.466804 [show with all ESTs]

Unigene Representative Sequence: BX366627

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000469162 ENST00000375111(uc001bcu.3 uc001bcv.3 uc010oda.2)

ENST00000496748 ENST00000491964 ENST00000482011 ENST00000461140 ENST00000400520(uc010odb.2)

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Additional cDNA sequence:

AK291302.1 AY656695.1 AY656696.1 BC005919.1 CR456865.1 M22430.1

12 DOTS entries:

DT.448973 DT.91875898 DT.100846638 DT.91740599 DT.100770687 DT.121358013 DT.91740607 DT.100028625

DT.95278396 DT.95278386 DT.97846892 DT.95278401

24/273 AceView cDNA sequences (see all 273):

AI916742 BU733241 BU726008 R80612 BQ181089 BQ183509 CF527749 CN479758

BC005919 BQ182317 BQ183493 H02619 CR600125 CR611816 T39452 BQ011250

AI734854 CR610647 CR605782 CR603279 BQ182722 AA131992 BU626291 NM_000300

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2A (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f
SP1:									-								-
SP2:									-		-						-
SP3:									-		-		-		-		-
SP4:
SP5:																							-

ECgene alternative splicing isoforms for PLA2G2A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLA2G2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGAAAGCAT

About this image
See PLA2G2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLA2G2A

SOURCE GeneReport for Unigene cluster: Hs.466804

SABiosciences Expression via Pathway-Focused PCR Array including PLA2G2A:

VEGF Signaling in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PLA2G2A gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLA2G2A¹	phospholipase A2, group IIA (platelets, synovial fluid)	55.24(n) 47.14(a)		426748 XM_424365.3 XP_424365.1
fruit fly (Drosophila melanogaster)	Insecta	CG14507⁶	--	10(a)	possible ortholog	3R(25051926-25053447)
worm (Caenorhabditis elegans)	Secernentea	C07E3.9⁶ Y69A2AL.2⁶	--	23(a) 22(a)	possible ortholog possible ortholog	II(10350700-10351557) IV(2482256-2484111)

ENSEMBL Gene Tree for PLA2G2A (if available)
TreeFam Gene Tree for PLA2G2A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PLA2G2A gene

ENSG00000258417² PLA2G2F² PLA2G1B² PLA2G2D² PLA2G2E² OC90² PLA2G10² PLA2G5²

PLA2G2C²

9 SIMAP similar genes for PLA2G2A using alignment to 2 protein entries: PA2GA_HUMAN (see all proteins):

PLA2 PLA2G2D PLA2G5 PLA2G2E PLA2G2F PLA2G1B

PLA2G10 OC90 PLA2G2C

PLA2G2A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11573177^1,2	C,F,	--	18547597(-)	`TCCCAG/CCTGCT`	4	--	ds500¹		2	NS CSA	170
rs11573176^1,2	C,F,H,	--	18547726(-)	`AAAGCA/CATTAG`	4	--	ut3¹		5	NS EA	598
rs11573175^1,2	C,F,H,	--	18547743(-)	`GGGGGT/CCTCTT`	4	--	ut3¹ ese³		6	NS EA WA	712
rs12567971^1,2	C,H	--	18548109(+)	`CTGCAG/AGAGTC`	8	/S	syn¹ ese³		6	NS EA NA	422
rs11573174^1,2	C,F,H,	--	18548289(-)	`CAAGGG/ACAAGA`	4	--	int¹		5	NS EA	588
rs12568211^1,2	H	--	18548703(+)	`GGCCAG/TGAGAA`	4	--	int¹		4	NS EA	420
rs74920743^1,2		--	18548882(+)	`GAGGCC/GATGAT`	4	--	int¹		1	NA	120
rs11573173^1,2	C,F,H,	--	18548887(-)	`CTCCCA/CTCATG`	4	--	int¹		6	NS EA WA	714
rs955586^1,2	H	--	18548973(-)	`CCCCAG/CACAGC`	4	--	int¹		4	NS EA	408
rs11573172^1,2	C,F,H,	--	18549002(-)	`GGGTGG/TCACTG`	4	--	int¹		6	NS EA WA	686

HapMap Linkage Disequilibrium report for PLA2G2A (20301924 - 20306932 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PLA2G2A: --
Human Gene Mutation Database (HGMD): PLA2G2A

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PLA2G2A for disorders           About GeneDecksing

OMIM gene information: 172411
OMIM disorders: 114500
20/108 diseases for PLA2G2A (see all 108):    About MalaCards

spinal cord ischemia open-angle glaucoma primary open angle glaucoma pancreatitis

familial adenomatous polyposis gas gangrene transient cerebral ischemia acute chest syndrome

adult respiratory distress syndrome adenomatous polyposis coli pre-eclampsia type 2 diabetes mellitus

coronary heart disease inflammatory bowel disease periodic fever lupus erythematosus

insulin resistance polyposis krabbe disease ischemia

2 diseases from the University of Copenhagen DISEASES database for PLA2G2A:

Acute chest syndrome Gas gangrene

10/94 Novoseek disease relationships for PLA2G2A gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	58.2	78	9849315 (2), 15224635 (2), 17573441 (2), 9748759 (2) (see all 60)
rheumatoid arthritis	36.7	25	1757123 (2), 1540785 (2), 8018333 (2), 19765281 (2) (see all 19)
intestinal polyps	36.3	2	8640784 (1), 9458096 (1)
necrosis	36.3	30	1477075 (1), 7684376 (1), 8596153 (1), 10090397 (1) (see all 29)
atherosclerosis	34.9	20	10381280 (3), 15897607 (2), 20153800 (2), 17353016 (2) (see all 12)
arthritis	32.6	10	2254899 (1), 2033260 (1), 11090064 (1), 10051149 (1) (see all 10)
shock septic	31.3	12	7780685 (3), 1757123 (2), 9219902 (2), 8490995 (2) (see all 7)
edema	31.3	22	8206646 (2), 1358548 (2), 8519280 (2), 11054123 (1) (see all 14)
acute pancreatitis	30.7	26	9135530 (4), 1459357 (3), 8472353 (2), 10077051 (2) (see all 10)
respiratory distress syndrome	28.5	6	11373495 (1), 8472353 (1), 18853138 (1), 11040450 (1) (see all 5)

Genetic Association Database (GAD): PLA2G2A
Human Genome Epidemiology (HuGE) Navigator: PLA2G2A (19 documents)

Export disorders for PLA2G2A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PLA2G2A gene, integrated from 9 sources (see all 821):
(articles sorted by number of sources associating them with PLA2G2A)

Utopia: connect your pdf to the dynamic
world of online information

Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2-A resolution. (PubMed id 2062381)^{1, 2, 9} Wery J.-P.... Jones N.D. (1991)
Allelic association analysis of phospholipase A2 genes with schizophrenia. (PubMed id 15318030)^{1, 4, 9} Junqueira R....Vallada H. (2004)
Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate. (PubMed id 1948070)^{1, 2, 9} Scott D.L....Sigler P.B. (1991)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study. (PubMed id 16368710)^{1, 4} Wootton P.T....Talmud P.J. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic association between the phospholipase A2 gene and unipolar affective disorder: a multicentre case-control study. (PubMed id 14639048)^{1, 4} Papadimitriou G.N....Mendlewicz J. (2003)
Crystal structure of human secretory phospholipase A2-IIA complex with the potent indolizine inhibitor 120-1032. (PubMed id 9538252)^{1, 2} Kitadokoro K.... Miki K. (1998)
Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. (PubMed id 8838795)^{1, 3} Tischfield J.A....Lusis A.J. (1996)
Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. (PubMed id 7664108)^{1, 2} Schevitz R.W.... Wery J.-P. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5320	HGNC: 9031	AceView: PLA2G2A	Ensembl:ENSG00000188257	euGenes: HUgn5320
ECgene: PLA2G2A	Kegg: 5320	H-InvDB: PLA2G2A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PLA2G2A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PLA2G2A	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/pla2g2a/

Intellectual Property for PLA2G2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PLA2G2A gene:
Search GeneIP for patents involving PLA2G2A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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PLA2G2A Gene

phospholipase A2, group IIA (platelets, synovial fluid)

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PLA2G2A Gene

phospholipase A2, group IIA (platelets, synovial fluid)

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