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Aliases for PLA2G2A Gene

Aliases for PLA2G2A Gene

  • Phospholipase A2, Group IIA (Platelets, Synovial Fluid) 2 3
  • PLA2L 3 4 6
  • PLA2B 3 4 6
  • Non-Pancreatic Secretory Phospholipase A2 3 4
  • Phosphatidylcholine 2-Acylhydrolase 2A 3 4
  • Group IIA Phospholipase A2 3 4
  • GIIC SPLA2 3 4
  • NPS-PLA2 3 4
  • MOM1 3 6
  • Phospholipase A2, Membrane Associated 3
  • EC 3.1.1.4 4
  • RASF-A 4
  • PLA2S 3
  • PLAS1 3
  • SPLA2 3
  • PLA2 3

External Ids for PLA2G2A Gene

Previous HGNC Symbols for PLA2G2A Gene

  • PLA2B
  • PLA2L

Previous GeneCards Identifiers for PLA2G2A Gene

  • GC01M019872
  • GC01M019337
  • GC01M019717
  • GC01M019771
  • GC01M020047
  • GC01M020174
  • GC01M020301
  • GC01M018547

Summaries for PLA2G2A Gene

Entrez Gene Summary for PLA2G2A Gene

  • The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for PLA2G2A Gene

PLA2G2A (Phospholipase A2, Group IIA (Platelets, Synovial Fluid)) is a Protein Coding gene. Diseases associated with PLA2G2A include small bowel adenocarcinoma and acute chest syndrome. Among its related pathways are Ras signaling pathway and PAK Pathway. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot for PLA2G2A Gene

  • Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Tocris Summary for PLA2G2A Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+ concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2A Gene

Genomics for PLA2G2A Gene

Regulatory Elements for PLA2G2A Gene

Genomic Location for PLA2G2A Gene

Start:
19,975,431 bp from pter
End:
19,980,439 bp from pter
Size:
5,009 bases
Orientation:
Minus strand

Genomic View for PLA2G2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2G2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2A Gene

Proteins for PLA2G2A Gene

  • Protein details for PLA2G2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14555-PA2GA_HUMAN
    Recommended name:
    Phospholipase A2, membrane associated
    Protein Accession:
    P14555
    Secondary Accessions:
    • A8K5I7
    • Q6DN24
    • Q6IBD9
    • Q9UCD2

    Protein attributes for PLA2G2A Gene

    Size:
    144 amino acids
    Molecular mass:
    16083 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Group II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and secreted forms are identical and are encoded by a single gene

    Three dimensional structures from OCA and Proteopedia for PLA2G2A Gene

neXtProt entry for PLA2G2A Gene

Proteomics data for PLA2G2A Gene at MOPED

Post-translational modifications for PLA2G2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

  • Cloud-Clone Corp. Proteins for PLA2G2A
  • antibodies-online proteins for PLA2G2A

No data available for DME Specific Peptides for PLA2G2A Gene

Domains for PLA2G2A Gene

Gene Families for PLA2G2A Gene

Protein Domains for PLA2G2A Gene

Suggested Antigen Peptide Sequences for PLA2G2A Gene

Graphical View of Domain Structure for InterPro Entry

P14555

UniProtKB/Swiss-Prot:

PA2GA_HUMAN :
  • P14555
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2A: view

Function for PLA2G2A Gene

Molecular function for PLA2G2A Gene

GENATLAS Biochemistry: phospholipase A2,group IIA,Ca2+ dependent,non pancreatic,secreted,expressed in platelets synovial fluid,potent mediator of the inflammatory process,enhanced by inflammatory cytokines as well as lipolysaccharides in various cell types,elevated in numerous inflammatory diseases including sepsis,Crohn disease and pancreatitis,deleted in neuroblastoma,not involved in colorectal carcinoma,homolog to murine Mom1 (see also MOM1,TSG1C)
UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Enzyme Numbers (IUBMB) for PLA2G2A Gene

Gene Ontology (GO) - Molecular Function for PLA2G2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0005543 phospholipid binding IDA 9032461
GO:0047498 calcium-dependent phospholipase A2 activity TAS 9272153
genes like me logo Genes that share ontologies with PLA2G2A: view

Phenotypes for PLA2G2A Gene

MGI mutant phenotypes for PLA2G2A:
inferred from 2 alleles
GenomeRNAi human phenotypes for PLA2G2A:
genes like me logo Genes that share phenotypes with PLA2G2A: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G2A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLA2G2A Gene

Localization for PLA2G2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2A Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G2A Gene COMPARTMENTS Subcellular localization image for PLA2G2A gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 4
plasma membrane 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PLA2G2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 17069818
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PLA2G2A: view

Pathways for PLA2G2A Gene

genes like me logo Genes that share pathways with PLA2G2A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PLA2G2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008285 negative regulation of cell proliferation --
GO:0010744 positive regulation of macrophage derived foam cell differentiation TAS 18827909
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G2A: view

Compounds for PLA2G2A Gene

(5) Tocris Compounds for PLA2G2A Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor [83373-60-8]
m-3M3FBS Phospholipase C activator [200933-14-8]
U 73343 Inactive analog of U 73122 (Cat. No. 1268) [142878-12-4]
VU 0155069 Potent and selective PLD1 inhibitor [1130067-06-9]
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor [1244640-48-9]

(2140) HMDB Compounds for PLA2G2A Gene

Compound Synonyms Cas Number PubMed IDs
Alpha-Linolenic acid
  • (9,12,15)-linolenate
463-40-1
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Calcium
  • Ca
7440-70-2
Heptadecanoic acid
  • Heptadecanoate
506-12-7

(112) Novoseek inferred chemical compound relationships for PLA2G2A Gene

Compound -log(P) Hits PubMed IDs
arachidonic acid 89.3 174
manoalide 86.5 16
scalaradial 85.9 9
ly311727 84.8 8
p-bromophenacyl bromide 84.3 27
genes like me logo Genes that share compounds with PLA2G2A: view

Transcripts for PLA2G2A Gene

Unigene Clusters for PLA2G2A Gene

Phospholipase A2, group IIA (platelets, synovial fluid):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G2A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - -
SP2: - - -
SP3: - - - - -
SP4:
SP5: -
SP6: -
SP7:

Relevant External Links for PLA2G2A Gene

GeneLoc Exon Structure for
PLA2G2A
ECgene alternative splicing isoforms for
PLA2G2A

Expression for PLA2G2A Gene

mRNA expression in normal human tissues for PLA2G2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G2A Gene

This gene is overexpressed in Heart - Atrial Appendage (9.1), Liver (8.2), and Artery - Coronary (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLA2G2A Gene

SOURCE GeneReport for Unigene cluster for PLA2G2A Gene Hs.466804

genes like me logo Genes that share expressions with PLA2G2A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PLA2G2A Gene

Orthologs for PLA2G2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G2A 35
  • 98.15 (n)
  • 97.22 (a)
PLA2G2A 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
OneToMany
LOC615045 35
  • 72.69 (n)
  • 63.19 (a)
PLA2G2A 36
  • 67 (a)
OneToMany
PLA2G2A 36
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pla2g2a 16
Pla2g2a 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g2a 35
  • 75.46 (n)
  • 72.22 (a)
chicken
(Gallus gallus)
Aves PLA2G2A 35
  • 55.48 (n)
  • 47.14 (a)
PLA2G5 36
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
Species with no ortholog for PLA2G2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2A Gene

ENSEMBL:
Gene Tree for PLA2G2A (if available)
TreeFam:
Gene Tree for PLA2G2A (if available)

Paralogs for PLA2G2A Gene

Paralogs for PLA2G2A Gene

Selected SIMAP similar genes for PLA2G2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLA2G2A: view

Variants for PLA2G2A Gene

Sequence variations from dbSNP and Humsavar for PLA2G2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4744 -- 19,978,433(-) TTCTA(C/T)GGCTG reference, synonymous-codon
rs11677 -- 19,975,471(-) TACTC(C/T)GGGGG utr-variant-3-prime
rs14945 -- 19,975,624(-) ACCAA(G/T)TTCCT utr-variant-3-prime
rs818958 -- 19,977,114(-) GAGAA(G/T)TCAGG intron-variant
rs876018 -- 19,975,434(+) TATAC(A/T)TGATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2A Gene

Variant ID Type Subtype PubMed ID
nsv871115 CNV Gain 21882294
nsv527818 CNV Gain 19592680

Relevant External Links for PLA2G2A Gene

HapMap Linkage Disequilibrium report
PLA2G2A
Human Gene Mutation Database (HGMD)
PLA2G2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G2A Gene

Disorders for PLA2G2A Gene

(1) OMIM Diseases for PLA2G2A Gene (172411)

(2) University of Copenhagen DISEASES for PLA2G2A Gene

(94) Novoseek inferred disease relationships for PLA2G2A Gene

Disease -log(P) Hits PubMed IDs
inflammation 58.2 69
rheumatoid arthritis 36.7 23
intestinal polyps 36.3 2
necrosis 36.3 29
atherosclerosis 34.9 17

Relevant External Links for PLA2G2A

Genetic Association Database (GAD)
PLA2G2A
Human Genome Epidemiology (HuGE) Navigator
PLA2G2A
genes like me logo Genes that share disorders with PLA2G2A: view

No data available for UniProtKB/Swiss-Prot for PLA2G2A Gene

Publications for PLA2G2A Gene

  1. Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2-A resolution. (PMID: 2062381) Wery J.-P. … Jones N.D. (Nature 1991) 3 4 23
  2. Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate. (PMID: 1948070) Scott D.L. … Sigler P.B. (Science 1991) 3 4 23
  3. Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. (PMID: 17545304) Wootton P.T. … Talmud P.J. (Hum. Mol. Genet. 2007) 3 23 48
  4. The role of phospholipases A2 in schizophrenia. (PMID: 16585943) Law M.H. … Berger G.E. (Mol. Psychiatry 2006) 3 23
  5. Impact of Phospholipase A2 group IIa gene polymorphism on phenotypic features of patients with familial adenomatous polyposis. (PMID: 17164967) Yanaru-Fujisawa R. … Iida M. (Dis. Colon Rectum 2007) 3 23

Products for PLA2G2A Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PLA2G2A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G2A
    • Block miRNA regulation of PLA2G2A using miScript Target Protectors

    Sources for PLA2G2A Gene

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