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Aliases for PLA2G2A Gene

Aliases for PLA2G2A Gene

  • Phospholipase A2 Group IIA 2 3 5
  • Phospholipase A2, Group IIA (Platelets, Synovial Fluid) 2 3
  • Non-Pancreatic Secretory Phospholipase A2 3 4
  • Phosphatidylcholine 2-Acylhydrolase 2A 3 4
  • Group IIA Phospholipase A2 3 4
  • GIIC SPLA2 3 4
  • NPS-PLA2 3 4
  • PLA2L 3 4
  • PLA2B 3 4
  • EC 3.1.1.4 4
  • RASF-A 4
  • SPLA2 3
  • PLA2S 3
  • PLAS1 3
  • PLA2 3
  • MOM1 3

External Ids for PLA2G2A Gene

Previous HGNC Symbols for PLA2G2A Gene

  • PLA2B
  • PLA2L

Previous GeneCards Identifiers for PLA2G2A Gene

  • GC01M019872
  • GC01M019337
  • GC01M019717
  • GC01M019771
  • GC01M020047
  • GC01M020174
  • GC01M020301
  • GC01M018547

Summaries for PLA2G2A Gene

Entrez Gene Summary for PLA2G2A Gene

  • The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for PLA2G2A Gene

PLA2G2A (Phospholipase A2 Group IIA) is a Protein Coding gene. Diseases associated with PLA2G2A include colorectal cancer and pancreatitis. Among its related pathways are Metabolism and Fat digestion and absorption. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2C.

UniProtKB/Swiss-Prot for PLA2G2A Gene

  • Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Tocris Summary for PLA2G2A Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G2A Gene

Genomics for PLA2G2A Gene

Regulatory Elements for PLA2G2A Gene

Genomic Location for PLA2G2A Gene

Chromosome:
1
Start:
19,975,431 bp from pter
End:
19,980,439 bp from pter
Size:
5,009 bases
Orientation:
Minus strand

Genomic View for PLA2G2A Gene

Genes around PLA2G2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G2A Gene

Proteins for PLA2G2A Gene

  • Protein details for PLA2G2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14555-PA2GA_HUMAN
    Recommended name:
    Phospholipase A2, membrane associated
    Protein Accession:
    P14555
    Secondary Accessions:
    • A8K5I7
    • Q6DN24
    • Q6IBD9
    • Q9UCD2

    Protein attributes for PLA2G2A Gene

    Size:
    144 amino acids
    Molecular mass:
    16083 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Group II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and secreted forms are identical and are encoded by a single gene.

    Three dimensional structures from OCA and Proteopedia for PLA2G2A Gene

neXtProt entry for PLA2G2A Gene

Proteomics data for PLA2G2A Gene at MOPED

Post-translational modifications for PLA2G2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G2A Gene

Antibody Products

No data available for DME Specific Peptides for PLA2G2A Gene

Domains & Families for PLA2G2A Gene

Gene Families for PLA2G2A Gene

Protein Domains for PLA2G2A Gene

Suggested Antigen Peptide Sequences for PLA2G2A Gene

Graphical View of Domain Structure for InterPro Entry

P14555

UniProtKB/Swiss-Prot:

PA2GA_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G2A: view

Function for PLA2G2A Gene

Molecular function for PLA2G2A Gene

GENATLAS Biochemistry:
phospholipase A2,group IIA,Ca2+ dependent,non pancreatic,secreted,expressed in platelets synovial fluid,potent mediator of the inflammatory process,enhanced by inflammatory cytokines as well as lipolysaccharides in various cell types,elevated in numerous inflammatory diseases including sepsis,Crohn disease and pancreatitis,deleted in neuroblastoma,not involved in colorectal carcinoma,homolog to murine Mom1 (see also MOM1,TSG1C)
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Enzyme Numbers (IUBMB) for PLA2G2A Gene

Gene Ontology (GO) - Molecular Function for PLA2G2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047498 calcium-dependent phospholipase A2 activity IEA,TAS 9272153
genes like me logo Genes that share ontologies with PLA2G2A: view
genes like me logo Genes that share phenotypes with PLA2G2A: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G2A Gene

Localization for PLA2G2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G2A Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G2A Gene COMPARTMENTS Subcellular localization image for PLA2G2A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
mitochondrion 3
cytosol 2
plasma membrane 2
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PLA2G2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PLA2G2A: view

Pathways & Interactions for PLA2G2A Gene

genes like me logo Genes that share pathways with PLA2G2A: view

Gene Ontology (GO) - Biological Process for PLA2G2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA,IDA 17069818
GO:0010744 positive regulation of macrophage derived foam cell differentiation TAS 18827909
GO:0016042 lipid catabolic process IEA --
GO:0034374 low-density lipoprotein particle remodeling TAS 18827909
GO:0036149 phosphatidylinositol acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with PLA2G2A: view

No data available for SIGNOR curated interactions for PLA2G2A Gene

Drugs & Compounds for PLA2G2A Gene

(73) Drugs for PLA2G2A Gene - From: Novoseek, DrugBank, HMDB, DGIdb, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suramin Approved Pharma Antagonist, Target, inhibitor 18
Indomethacin Approved, Investigational Pharma Partial agonist, Agonist, Target, inhibitor Cox inhibitor 106
Diclofenac Approved Pharma Channel blocker, Target, inhibitor 273
Ginkgo biloba Approved Nutra Target, inhibitor 0
Clofazimine Approved, Investigational Pharma Tuberculosis drug 21

(81) Additional Compounds for PLA2G2A Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Dodecanoic acid
  • 1-Undecanecarboxylate
  • 1-Undecanecarboxylic acid
  • ABL
  • Aliphat No. 4
  • Dodecanoate
143-07-7
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6

(5) Tocris Compounds for PLA2G2A Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7

(6) ApexBio Compounds for PLA2G2A Gene

Compound Action Cas Number
Anti-Inflammatory Peptide 1 PLA2 inhibitor 118850-71-8
Clofazimine Tuberculosis drug 2030-63-9
CP-91149 Selective inhibitor of glycogen phosphorylase 186392-40-5
Halobetasol Propionate 66852-54-8
Quercetin dihydrate PLA2 and PI 3-kinase inhibitor 6151-25-3
Varespladib (LY315920) HnsPLA inhibitor,potent and selective 172732-68-2
genes like me logo Genes that share compounds with PLA2G2A: view

Transcripts for PLA2G2A Gene

Unigene Clusters for PLA2G2A Gene

Phospholipase A2, group IIA (platelets, synovial fluid):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - -
SP2: - - -
SP3: - - - - -
SP4:
SP5: -
SP6: -
SP7:

Relevant External Links for PLA2G2A Gene

GeneLoc Exon Structure for
PLA2G2A
ECgene alternative splicing isoforms for
PLA2G2A

Expression for PLA2G2A Gene

mRNA expression in normal human tissues for PLA2G2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G2A Gene

This gene is overexpressed in Heart - Atrial Appendage (x9.1), Liver (x8.2), and Artery - Coronary (x4.6).

Protein differential expression in normal tissues from HIPED for PLA2G2A Gene

This gene is overexpressed in Gallbladder (27.8), Prostate (9.6), and Pancreatic juice (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G2A Gene



SOURCE GeneReport for Unigene cluster for PLA2G2A Gene Hs.466804

genes like me logo Genes that share expression patterns with PLA2G2A: view

Protein tissue co-expression partners for PLA2G2A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PLA2G2A Gene

Orthologs for PLA2G2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLA2G2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC615045 35
  • 72.69 (n)
  • 63.19 (a)
-- 36
  • 63 (a)
OneToMany
PLA2G2A 36
  • 67 (a)
OneToMany
PLA2G2A 36
  • 63 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PLA2G2A 35
  • 98.15 (n)
  • 97.22 (a)
PLA2G2A 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g2a 35
  • 75.46 (n)
  • 72.22 (a)
mouse
(Mus musculus)
Mammalia Pla2g2a 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G2A 35
  • 55.48 (n)
  • 47.14 (a)
PLA2G5 36
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
Species with no ortholog for PLA2G2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLA2G2A Gene

ENSEMBL:
Gene Tree for PLA2G2A (if available)
TreeFam:
Gene Tree for PLA2G2A (if available)

Paralogs for PLA2G2A Gene

(9) SIMAP similar genes for PLA2G2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLA2G2A: view

Variants for PLA2G2A Gene

Sequence variations from dbSNP and Humsavar for PLA2G2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11573162 - 19,978,510(-) AGGCC(C/T)ATGGG reference, missense
rs4744 -- 19,978,433(-) TTCTA(C/T)GGCTG reference, synonymous-codon
rs11677 -- 19,975,471(-) TACTC(C/T)GGGGG utr-variant-3-prime
rs14945 -- 19,975,624(-) ACCAA(G/T)TTCCT utr-variant-3-prime
rs818958 -- 19,977,114(-) GAGAA(G/T)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G2A Gene

Variant ID Type Subtype PubMed ID
nsv871115 CNV Gain 21882294
nsv527818 CNV Gain 19592680

Variation tolerance for PLA2G2A Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G2A Gene

HapMap Linkage Disequilibrium report
PLA2G2A
Human Gene Mutation Database (HGMD)
PLA2G2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G2A Gene

Disorders for PLA2G2A Gene

MalaCards: The human disease database

(18) MalaCards diseases for PLA2G2A Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
pancreatitis
gas gangrene
  • gas bacillus infection
splenic infarction
  • splenic infarct
krabbe disease
  • beta galactocerebrosidase deficiency
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2G2A

Genetic Association Database (GAD)
PLA2G2A
Human Genome Epidemiology (HuGE) Navigator
PLA2G2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G2A
genes like me logo Genes that share disorders with PLA2G2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G2A Gene

Publications for PLA2G2A Gene

  1. Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2-A resolution. (PMID: 2062381) Wery J.-P. … Jones N.D. (Nature 1991) 3 4 23 67
  2. Suramin inhibits macrophage activation by human group IIA phospholipase A2, but does not affect bactericidal activity of the enzyme. (PMID: 19169647) AragALo E.A. … Ward R.J. (Inflamm. Res. 2009) 3 23
  3. PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma. (PMID: 19276398) Buhmeida A. … PyrhAPnen S. (Ann. Oncol. 2009) 3 23
  4. Effects of cholesterol on physical properties of human erythrocyte membranes: impact on susceptibility to hydrolysis by secretory phospholipase A2. (PMID: 18192373) Heiner A.L. … Bell J.D. (Biophys. J. 2008) 3 23
  5. Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation. (PMID: 17069818) Luchtefeld M. … Schieffer B. (Atherosclerosis 2007) 3 23

Products for PLA2G2A Gene

Sources for PLA2G2A Gene

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