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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLA2G2A Gene

protein-coding   GIFtS: 72
GCID: GC01M020301

Phospholipase A2, Group IIA (Platelets, Synovial Fluid)


(Previous symbols: PLA2B, PLA2L)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase A2, Group IIA (Platelets, Synovial Fluid)1 2     MOM12 5
PLA2B1 2 3 5     PLA22
PLA2L1 2 3 5     PLA2S2
Group IIA Phospholipase A22 3     PLAS12
Non-Pancreatic Secretory Phospholipase A22 3     Phospholipase A2, Membrane Associated2
Phosphatidylcholine 2-Acylhydrolase 2A2 3     sPLA22
NPS-PLA22 3     EC 3.1.1.43
GIIC SPLA22 3     RASF-A3

External Ids:    HGNC: 90311   Entrez Gene: 53202   Ensembl: ENSG000001882577   OMIM: 1724115   UniProtKB: P145553   

Export aliases for PLA2G2A gene to outside databases

Previous GC identifers: GC01M019872 GC01M019337 GC01M019717 GC01M019771 GC01M020047 GC01M020174 GC01M018547


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLA2G2A Gene:
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse
family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene
product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low
molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl
ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in
the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants
with different 5' UTRs have been found for this gene.(provided by RefSeq, Sep 2009)

GeneCards Summary for PLA2G2A Gene: 
PLA2G2A (phospholipase A2, group IIA (platelets, synovial fluid)) is a protein-coding gene. Diseases associated with PLA2G2A include small bowel adenocarcinoma, and spinal cord ischemia, and among its related super-pathways are Acyl chain remodelling of PC and Glycerophospholipid biosynthesis. GO annotations related to this gene include phospholipase A2 activity and calcium ion binding. An important paralog of this gene is ENSG00000258417.

UniProtKB/Swiss-Prot: PA2GA_HUMAN, P14555
Function: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including
eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in
3-sn-phosphoglycerides

summary for PLA2G2A Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLA2G2A gene promoter:
         Nkx3-1   Nkx3-1 v4   Egr-1   Nkx3-1 v1   STAT5A   MEF-2A   Nkx3-1 v2   Chx10   Nkx3-1 v3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PLA2G2A promoter sequence
   Search SABiosciences Chromatin IP Primers for PLA2G2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p35

PLA2G2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G2A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M020301:  view genomic region     (about GC identifiers)

Start:
20,301,924 bp from pter      End:
20,306,932 bp from pter
Size:
5,009 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PA2GA_HUMAN, P14555 (See protein sequence)
Recommended Name: Phospholipase A2, membrane associated precursor  
Size: 144 amino acids; 16083 Da
Cofactor: Binds 1 calcium ion per subunit
Subcellular location: Membrane; Peripheral membrane protein
Miscellaneous: Group II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and
secreted forms are identical and are encoded by a single gene
6/17 PDB 3D structures from and Proteopedia for PLA2G2A (see all 17):
1AYP (3D)        1BBC (3D)        1DB4 (3D)        1DB5 (3D)        1DCY (3D)        1J1A (3D)    
Secondary accessions: A8K5I7 Q6DN24 Q6IBD9 Q9UCD2

Explore the universe of human proteins at neXtProt for PLA2G2A: NX_P14555

Explore proteomics data for PLA2G2A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14555

  • PLA2G2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLA2G2A Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_000291.1  NP_001155199.1  NP_001155200.1  NP_001155201.1  

    ENSEMBL proteins: 
     ENSP00000364252   ENSP00000383364  
    Reactome Protein details: P14555
    Human Recombinant Protein Products for PLA2G2A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for PLA2G2A
    OriGene Protein Over-expression Lysate for PLA2G2A
    OriGene MassSpec for PLA2G2A 
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    Novus Biologicals PLA2G2A Proteins
    Novus Biologicals PLA2G2A Lysate
    Sino Biological Recombinant Protein for PLA2G2A
    Sino Biological Cell Lysate for PLA2G2A 
    ProSpec Recombinant Protein for PLA2G2A
    Cloud-Clone Corp. Proteins for PLA2G2A 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA17069818
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0030141secretory granule IEA--

    PLA2G2A for ontologies           About GeneDecksing



    PLA2G2A Antibody Products: 
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    Novus Biologicals PLA2G2A Antibodies
    Abcam antibodies for PLA2G2A
    Cloud-Clone Corp. Antibodies for PLA2G2A 
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    LSBio Antibodies in human, mouse, rat for PLA2G2A 

    Assay Products for PLA2G2A: 
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    GenScript Custom Assay Services for PLA2G2A
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    Cloud-Clone Corp. ELISAs for PLA2G2A 
    Cloud-Clone Corp. CLIAs for PLA2G2A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: sPLA2-2A 
    Phospholipase A2

    3 InterPro protein domains:
     IPR016090 PLipase_A2_dom
     IPR001211 PLipase_A2
     IPR013090 PLipase_A2_AS

    Graphical View of Domain Structure for InterPro Entry P14555

    ProtoNet protein and cluster: P14555

    1 Blocks protein domain: IPB001211 Phospholipase A2

    UniProtKB/Swiss-Prot: PA2GA_HUMAN, P14555
    Similarity: Belongs to the phospholipase A2 family


    PLA2G2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PA2GA_HUMAN, P14555
    Function: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including
    eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in
    3-sn-phosphoglycerides
    Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate

         Genatlas biochemistry entry for PLA2G2A:
    phospholipase A2,group IIA,Ca2+ dependent,non pancreatic,secreted,expressed in platelets synovial fluid,potent
    mediator of the inflammatory process,enhanced by inflammatory cytokines as well as lipolysaccharides in various
    cell types,elevated in numerous inflammatory diseases including sepsis,Crohn disease and pancreatitis,deleted in
    neuroblastoma,not involved in colorectal carcinoma,homolog to murine Mom1 (see also MOM1,TSG1C)

         Enzyme Number (IUBMB): EC 3.1.1.41

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004623phospholipase A2 activity TAS--
    GO:0005509calcium ion binding IEA--
    GO:0005543phospholipid binding IDA9032461
    GO:0047498calcium-dependent phospholipase A2 activity TAS9272153
         
    PLA2G2A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PLA2G2A:
     Increased G1 DNA content  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pla2g2a):
     tumorigenesis 

    PLA2G2A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLA2G2A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PLA2G2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PLA2G2A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PLA2G2A 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPLA2G2A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PLA2G2A

    Clone
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    OriGene clones in human, mouse for PLA2G2A (see all 19)
    OriGene ORF clones in mouse, rat for PLA2G2A
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    GenScript: all cDNA clones in your preferred vector (see all 4): PLA2G2A (NM_000300)
    Sino Biological Human cDNA Clone for PLA2G2A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G2A
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                         Customized lentivirus expression plasmids for stable overexpression of PLA2G2A 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G2A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLA2G2A About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Acyl chain remodelling of PE
    Acyl chain remodelling of PE0.85
    Acyl chain remodelling of PG0.62
    Acyl chain remodelling of PC0.85
    Ether lipid metabolism0.46
    Acyl chain remodelling of PS0.74
    Synthesis of PA0.41
    Acyl chain remodelling of PI0.65
    2Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    4Anandamide biosynthesis and metabolism
    Anandamide biosynthesis and metabolism0.34
    phospholipases0.34
    5PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    all-trans-Retinoic Acid Signaling in Brain0.71
    MIF Regulation of Innate Immune Cells0.94
    Endothelin-1 Signaling Pathway0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PLA2G2A
        Immune response CD16 signaling in NK cells
    Anandamide biosynthesis and metabolism

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLA2G2A (see all 13)
        Chemokine Signaling
    MIF Regulation of Innate Immune Cells
    DHA Signaling
    Endothelin-1 Signaling Pathway
    Antioxidant Action of Vitamin-C

    2 GeneGo (Thomson Reuters) Pathways for PLA2G2A
        Anandamide biosynthesis and metabolism
    Immune response CD16 signaling in NK cells

    5 BioSystems Pathways for PLA2G2A
        MicroRNAs in cardiomyocyte hypertrophy
    Eicosanoid Synthesis
    Spinal Cord Injury
    Glypican 1 network
    phospholipases


    5/10        Reactome Pathways for PLA2G2A (see all 10)
        Acyl chain remodelling of PE
    Synthesis of PA
    Metabolism
    Acyl chain remodelling of PC
    Acyl chain remodelling of PG

    2 PharmGKB Pathways for PLA2G2A
        Celecoxib Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    5/9         Kegg Pathways  (Kegg details for PLA2G2A) (see all 9):
        Glycerophospholipid metabolism
    Ether lipid metabolism
    Arachidonic acid metabolism
    Linoleic acid metabolism
    alpha-Linolenic acid metabolism


    PLA2G2A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLA2G2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/113 Interacting proteins for PLA2G2A (P145552, 3 ENSP000003642524) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP70Q8NHQ12, 3, ENSP000002649824MINT-8266733 I2D: score=2 STRING: ENSP00000264982
    CRMP1Q141942, 3MINT-63475 I2D: score=3 
    CRELD2Q6UXH12, 3MINT-8266722 I2D: score=1 
    BAG6P463793I2D: score=1 
    ENSG00000096155P463793I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0010744positive regulation of macrophage derived foam cell differentiation TAS18827909
    GO:0016042lipid catabolic process IEA--
    GO:0034374low-density lipoprotein particle remodeling TAS18827909

    PLA2G2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLA2G2A for compounds           About GeneDecksing

    EMD Millipore small molecules for PLA2G2A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PLA2G2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    10/2140 HMDB Compounds for PLA2G2A (see all 2140)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    Alpha-Linolenic acid(9,12,15)-linolenate (see all 23)463-40-1--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    CalciumCa (see all 2)7440-70-2--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--

    10/14 DrugBank Compounds for PLA2G2A (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,4-Butanediol-- 110-63-4target--17139284 17016423 10592235
    1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid-- --target--17139284 17016423 10592235
    4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid-- --target--17139284 17016423 10592235
    DiclofenacDiclofenac Acid (see all 4)15307-86-5targetinhibitor9279965 15906762 16552142
    Elaidoylamide-- --target--17139284 17016423 10592235
    Ginkgo bilobaAdiantifolia (see all 13)--targetinhibitor10418340 10619176 16651744
    [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid-- --target--17139284 17016423 10592235
    (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid-- --target--17139284 17016423
    1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide-- --target--17139284 17016423
    6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid-- --target--17139284 17016423

    10/112 Novoseek inferred chemical compound relationships for PLA2G2A gene (see all 112)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 89.3 431 8636097 (5), 12813050 (5), 10657662 (5), 8555268 (4) (see all 99)
    manoalide 86.5 23 8702436 (4), 8228253 (3), 9677277 (1), 10051149 (1) (see all 11)
    scalaradial 85.9 13 17691073 (3), 8228253 (3), 10353635 (1), 8688196 (1) (see all 5)
    ly311727 84.8 10 11934806 (2), 17069818 (1), 8764358 (1), 12829607 (1) (see all 7)
    p-bromophenacyl bromide 84.3 44 2402761 (3), 8820966 (1), 9506985 (1), 11090064 (1) (see all 25)
    aacocf3 83.7 31 8195210 (2), 11800413 (2), 12558054 (1), 15082220 (1) (see all 18)
    bromoenol lactone 79.3 21 15082220 (1), 15474031 (1), 15950537 (1), 17537804 (1) (see all 13)
    7,7-dimethyl-eicosadienoic acid 79.1 3 16645197 (1), 12688422 (1), 1906891 (1)
    mafp 77.8 16 11641267 (1), 10026244 (1), 12039969 (1), 17374479 (1) (see all 8)
    phospholipid 76.7 91 11159446 (3), 9154867 (2), 9180373 (2), 9692992 (2) (see all 68)

    Search CenterWatch for drugs/clinical trials and news about PLA2G2A / PA2GA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLA2G2A gene (4 alternative transcripts): 
    NM_000300.3  NM_001161727.1  NM_001161728.1  NM_001161729.1  

    Unigene Cluster for PLA2G2A:

    Phospholipase A2, group IIA (platelets, synovial fluid)
    Hs.466804  [show with all ESTs]
    Unigene Representative Sequence: BX366627
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469162 ENST00000496748 ENST00000375111(uc001bcu.3 uc001bcv.3 uc010oda.2)
    ENST00000491964 ENST00000482011 ENST00000461140 ENST00000400520(uc010odb.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PLA2G2A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PLA2G2A
    SwitchGear 3'UTR luciferase reporter plasmidPLA2G2A 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK291302.1 AY656695.1 AY656696.1 BC005919.1 CR456865.1 M22430.1 

    12 DOTS entries:

    DT.448973  DT.91875898  DT.100846638  DT.91740599  DT.100770687  DT.121358013  DT.91740607  DT.100028625 
    DT.95278396  DT.95278386  DT.97846892  DT.95278401 

    24/273 AceView cDNA sequences (see all 273):

    CN479758 BU734454 CR593348 N69967 BC005919 CR616360 N57336 BQ004316 
    R80612 BU733241 BM686160 AI150776 BX358510 CB132375 T39452 BU626291 
    AA320357 H02619 BQ183493 CR596161 CR611816 CR605782 CF527749 AI916742 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G2A (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                          -                       -                                                                     
    SP2:                          -     -                 -                                                                     
    SP3:                          -     -     -     -     -                                                                     
    SP4:                                                                                                                        
    SP5:                                                                    -                                                   


    ECgene alternative splicing isoforms for PLA2G2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLA2G2A expression in normal human tissues (normalized intensities)      PLA2G2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAAAGCAT
    PLA2G2A Expression
    About this image


    PLA2G2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Chorion (Extraembryonic Tissues)
             Human Chorionic Mesenchymal Stromal Cells (HCMSC)   
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Intestine (Gastrointestinal Tract)
             small intestine   
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Brain (Nervous System)
             Trigeminal Ganglion   

    See PLA2G2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLA2G2A

    SOURCE GeneReport for Unigene cluster: Hs.466804
        SABiosciences Expression via Pathway-Focused PCR Array including PLA2G2A: 
              VEGF Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PLA2G2A gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2g2a5 phospholipase A2, group IIA (platelets, synovial fluid)   --   4 (70.57 cM) 138831860 
    chicken
    (Gallus gallus)
    Aves PLA2G2A1 phospholipase A2, group IIA (platelets, synovial fluid) 55.24(n)
    47.14(a)
      426748  XM_424365.3  XP_424365.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLA2G2D6
    Uncharacterized protein
    52(a)
    possible ortholog
    AAWZ02041529(3693-5527)


    ENSEMBL Gene Tree for PLA2G2A (if available)
    TreeFam Gene Tree for PLA2G2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLA2G2A gene
    ENSG000002584172  PLA2G2F2  PLA2G2E2  PLA2G1B2  PLA2G2D2  OC902  PLA2G102  PLA2G52  
    PLA2G2C2  
    9 SIMAP similar genes for PLA2G2A using alignment to 2 protein entries:     PA2GA_HUMAN (see all proteins):
    PLA2    PLA2G2D    PLA2G5    PLA2G2E    PLA2G2F    PLA2G1B
    PLA2G10    OC90    PLA2G2C

    PLA2G2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/210 SNPs in PLA2G2A are shown (see all 210)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115731441,2
    C,F--18553053(-) ATTCT-/TACACC 4 -- us2k12Minor allele frequency- T:0.46NS NA 172
    rs718576651,2
    C--20305467(+) CAATG-/CACACAC 4 -- int10--------
    rs115731341,2
    C,F--20308693(-) GCTTAT/CTAAGG 3 -- us2k12Minor allele frequency- C:0.03NS WA 280
    rs1840533301,2
    --20511820(+) GCACCA/GGTGTT 4 -- ds50010--------
    rs1386984091,2
    --20511836(+) CATCTA/GGATGA 4 -- ds50010--------
    rs37672211,2
    C,F,A--20511999(+) CAATCA/CTTGCA 4 -- ds50017Minor allele frequency- C:0.30NS NA WA EA 532
    rs115731771,2
    C,F--20512029(-) TCCCAG/CCTGCT 4 -- ds50012Minor allele frequency- C:0.02NS CSA 170
    rs8760181,2
    C,F,A,H--20512145(+) TATACA/TTGATT 4 -- ut3135Minor allele frequency- T:0.20EA NA NS CSA WA 3620
    rs115731761,2
    C,F,H--20512158(-) AAAGCA/CATTAG 4 -- ut315Minor allele frequency- C:0.00NS EA 598
    rs115731751,2
    C,F,H--20512175(-) GGGGGT/CCTCTT 4 -- ut31 ese36Minor allele frequency- C:0.01NS EA WA 712

    HapMap Linkage Disequilibrium report for PLA2G2A (20301924 - 20306932 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PLA2G2A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871115CNV Gain21882294
    nsv527818CNV Gain19592680


    Human Gene Mutation Database (HGMD): PLA2G2A
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 172411   
    OMIM disorders: 114500  
    20/94 diseases for PLA2G2A (see all 94):    About MalaCards
    small bowel adenocarcinoma    spinal cord ischemia    acute chest syndrome    transient cerebral ischemia
    surfactant dysfunction    allergic conjunctivitis    krabbe disease    gas gangrene
    familial adenomatous polyposis    acute pancreatitis    ischemia    vascular dementia
    adult respiratory distress syndrome    pancreatitis    cystitis    pancreatic diseases
    synovitis    brain disease    conjunctivitis    open-angle glaucoma

    2 diseases from the University of Copenhagen DISEASES database for PLA2G2A:
    Acute chest syndrome     Gas gangrene

    PLA2G2A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for PLA2G2A gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 58.2 78 9849315 (2), 15224635 (2), 17573441 (2), 9748759 (2) (see all 60)
    rheumatoid arthritis 36.7 25 1757123 (2), 1540785 (2), 8018333 (2), 19765281 (2) (see all 19)
    intestinal polyps 36.3 2 8640784 (1), 9458096 (1)
    necrosis 36.3 30 1477075 (1), 7684376 (1), 8596153 (1), 10090397 (1) (see all 29)
    atherosclerosis 34.9 20 10381280 (3), 15897607 (2), 20153800 (2), 17353016 (2) (see all 12)
    arthritis 32.6 10 2254899 (1), 2033260 (1), 11090064 (1), 10051149 (1) (see all 10)
    shock septic 31.3 12 7780685 (3), 1757123 (2), 9219902 (2), 8490995 (2) (see all 7)
    edema 31.3 22 8206646 (2), 1358548 (2), 8519280 (2), 11054123 (1) (see all 14)
    acute pancreatitis 30.7 26 9135530 (4), 1459357 (3), 8472353 (2), 10077051 (2) (see all 10)
    respiratory distress syndrome 28.5 6 11373495 (1), 8472353 (1), 18853138 (1), 11040450 (1) (see all 5)

    Genetic Association Database (GAD): PLA2G2A
    Human Genome Epidemiology (HuGE) Navigator: PLA2G2A (19 documents)

    Export disorders for PLA2G2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLA2G2A gene, integrated from 9 sources (see all 829):
    (articles sorted by number of sources associating them with PLA2G2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2-A resolution. (PubMed id 2062381)1, 2, 9 Wery J.-P.... Jones N.D. (1991)
    2. Allelic association analysis of phospholipase A2 genes with schizophrenia. (PubMed id 15318030)1, 4, 9 Junqueira R....Vallada H. (2004)
    3. Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. (PubMed id 17545304)1, 4, 9 Wootton P.T....Talmud P.J. (2007)
    4. Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate. (PubMed id 1948070)1, 2, 9 Scott D.L....Sigler P.B. (1991)
    5. Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. (PubMed id 20463618)1, 4 Abu-Maziad A....Murray J.C. (2010)
    6. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    7. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Molecular and functional characterization of polymorp hisms in the secreted phospholipase A2 group X gene: relevance to coronary arte ry disease. (PubMed id 19495570)1, 4 Gora S....Karabina S.A. (2009)
    10. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5320 HGNC: 9031 AceView: PLA2G2A Ensembl:ENSG00000188257 euGenes: HUgn5320
    ECgene: PLA2G2A Kegg: 5320 H-InvDB: PLA2G2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLA2G2A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PLA2G2A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/pla2g2a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLA2G2A gene:
    Search GeneIP for patents involving PLA2G2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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