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Aliases for PLA2G1B Gene

Aliases for PLA2G1B Gene

  • Phospholipase A2 Group IB 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 1B 3 4
  • Phospholipase A2, Group IB (Pancreas) 2 3
  • EC 3.1.1.4 4 61
  • PLA2A 3 4
  • PPLA2 3 4
  • PLA2 3 4
  • Group IB Phospholipase A2 4
  • Phospholipase A2 3

External Ids for PLA2G1B Gene

Previous HGNC Symbols for PLA2G1B Gene

  • PLA2
  • PPLA2
  • PLA2A

Previous GeneCards Identifiers for PLA2G1B Gene

  • GC12M119633
  • GC12M120286
  • GC12M120542
  • GC12M119171
  • GC12M119222
  • GC12M119244
  • GC12M120759
  • GC12M117768

Summaries for PLA2G1B Gene

Entrez Gene Summary for PLA2G1B Gene

  • This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

GeneCards Summary for PLA2G1B Gene

PLA2G1B (Phospholipase A2 Group IB) is a Protein Coding gene. Diseases associated with PLA2G1B include Distal Hereditary Motor Neuropathy, Type Ii. Among its related pathways are Linoleic acid metabolism and Vascular smooth muscle contraction. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G2D.

UniProtKB/Swiss-Prot for PLA2G1B Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.

Tocris Summary for PLA2G1B Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G1B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G1B Gene

Genomics for PLA2G1B Gene

Regulatory Elements for PLA2G1B Gene

Enhancers for PLA2G1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G120223 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +96.2 96205 16.0 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PXN SIRT4 RPLP0 RNU4-1 RNU4-2 PXN-AS1 PLA2G1B GCN1 RAB35 MSI1
GH12G120239 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +78.3 78259 19.3 CREB3L1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GCN1 SIRT4 RNU4-2 RNU4-1 RNU6-1088P PLA2G1B PXN BICDL1 RNF10 RAB35
GH12G120388 1.3 Ensembl ENCODE dbSUPER 11.4 -61.6 -61614 1.6 HINFP SUZ12 ZFP64 MAX ZNF175 ZNF366 POLR2A ZNF600 ZBTB20 ZNF263 MSI1 SIRT4 PLA2G1B ENSG00000111780 COX6A1 RNU6-1088P ENSG00000256695 RPS27P25
GH12G120430 1.2 Ensembl ENCODE 11.7 -102.8 -102775 0.3 ATF1 ARID4B SIN3A ZNF2 ZNF48 CBX5 ZNF207 ZNF143 KLF7 KLF13 MSI1 RPS27P25 RPL31P52 PLA2G1B DYNLL1 SRSF9 RNU6-1088P SIRT4 PXN COX6A1
GH12G120301 1.1 ENCODE 10.8 +25.2 25228 1.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 SIRT4 PXN PLA2G1B RPS27P25 MSI1 RNU4-1 GC12M120294 RNU6-1088P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLA2G1B on UCSC Golden Path with GeneCards custom track

Promoters for PLA2G1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058297 1988 799 PKNOX1 ATF1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for PLA2G1B Gene

Chromosome:
12
Start:
120,322,111 bp from pter
End:
120,327,789 bp from pter
Size:
5,679 bases
Orientation:
Minus strand

Genomic View for PLA2G1B Gene

Genes around PLA2G1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G1B Gene

Proteins for PLA2G1B Gene

  • Protein details for PLA2G1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04054-PA21B_HUMAN
    Recommended name:
    Phospholipase A2
    Protein Accession:
    P04054
    Secondary Accessions:
    • B2R4H5
    • Q3KPI1

    Protein attributes for PLA2G1B Gene

    Size:
    148 amino acids
    Molecular mass:
    16360 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Monomer or homodimer (By similarity). The inactive pro-form is a homotrimer.

    Three dimensional structures from OCA and Proteopedia for PLA2G1B Gene

neXtProt entry for PLA2G1B Gene

Selected DME Specific Peptides for PLA2G1B Gene

P04054:
  • QTHDNCY
  • GGSGTPVD
  • AFICNCDR
  • YGCYCGLGG
  • HKNLDTKKYC

Post-translational modifications for PLA2G1B Gene

  • Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.

Other Protein References for PLA2G1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PLA2G1B (PLA2G1B)
  • Cloud-Clone Corp. Antibodies for PLA2G1B

Protein Products

  • Cloud-Clone Corp. Proteins for PLA2G1B

Domains & Families for PLA2G1B Gene

Gene Families for PLA2G1B Gene

Protein Domains for PLA2G1B Gene

Graphical View of Domain Structure for InterPro Entry

P04054

UniProtKB/Swiss-Prot:

PA21B_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G1B: view

Function for PLA2G1B Gene

Molecular function for PLA2G1B Gene

GENATLAS Biochemistry:
phospholipase A2,Ca2+ dependent,group 1B,pancreatic,secreted,cleaved by caspase 1 and caspase 8,for proteolysis and inactivation during apoptosis,inducing cell proliferation,smooth muscle contraction and lipid mediator release
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.

Enzyme Numbers (IUBMB) for PLA2G1B Gene

Gene Ontology (GO) - Molecular Function for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity TAS,IEA --
GO:0005102 receptor binding IPI 7721806
GO:0005509 calcium ion binding IEA,IDA 7060561
GO:0016787 hydrolase activity IEA --
GO:0032052 bile acid binding ISS 7060561
genes like me logo Genes that share ontologies with PLA2G1B: view
genes like me logo Genes that share phenotypes with PLA2G1B: view

Animal Models for PLA2G1B Gene

MGI Knock Outs for PLA2G1B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G1B Gene

Localization for PLA2G1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G1B Gene

Secreted. Note=secreted from pancreatic acinar cells in its inactive form.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G1B gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
lysosome 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 7060561
GO:0005829 cytosol IDA --
GO:0009986 cell surface IDA 1918029
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with PLA2G1B: view

Pathways & Interactions for PLA2G1B Gene

genes like me logo Genes that share pathways with PLA2G1B: view

SIGNOR curated interactions for PLA2G1B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLA2G1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity ISS 15528384
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0002446 neutrophil mediated immunity ISS 16005851
GO:0006629 lipid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IDA 1918029
genes like me logo Genes that share ontologies with PLA2G1B: view

Drugs & Compounds for PLA2G1B Gene

(39) Drugs for PLA2G1B Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niflumic Acid Approved Pharma Channel blocker, inhibitor, Target Ca2+-activated Cl- channel blocker 0
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Sulfasalazine Approved Pharma Inhibition, Inhibitor, Target, antagonist NF-κB activation inhibitor 60
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0

(77) Additional Compounds for PLA2G1B Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)

(5) Tocris Compounds for PLA2G1B Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
U 73343 Analog of U 73122 (Cat. No. 1268) 142878-12-4
VU 0155069 Potent and selective PLD1 inhibitor 1130067-06-9
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor 1244640-48-9
genes like me logo Genes that share compounds with PLA2G1B: view

Transcripts for PLA2G1B Gene

mRNA/cDNA for PLA2G1B Gene

Unigene Clusters for PLA2G1B Gene

Phospholipase A2, group IB (pancreas):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for PLA2G1B Gene

GeneLoc Exon Structure for
PLA2G1B
ECgene alternative splicing isoforms for
PLA2G1B

Expression for PLA2G1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G1B Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for PLA2G1B Gene

This gene is overexpressed in Pancreatic juice (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G1B Gene



Protein tissue co-expression partners for PLA2G1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLA2G1B Gene:

PLA2G1B

SOURCE GeneReport for Unigene cluster for PLA2G1B Gene:

Hs.992

Evidence on tissue expression from TISSUES for PLA2G1B Gene

  • Pancreas(4.9)
  • Lung(4.5)
  • Blood(2.6)
  • Heart(2.4)
  • Muscle(2.3)
  • Intestine(2.2)
  • Kidney(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with PLA2G1B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G1B Gene

Orthologs for PLA2G1B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G1B 34 35
  • 98.87 (n)
dog
(Canis familiaris)
Mammalia PLA2G1B 34 35
  • 84.47 (n)
rat
(Rattus norvegicus)
Mammalia Pla2g1b 34
  • 81.25 (n)
mouse
(Mus musculus)
Mammalia Pla2g1b 34 16 35
  • 80.21 (n)
cow
(Bos Taurus)
Mammalia PLA2G1B 34 35
  • 78.79 (n)
oppossum
(Monodelphis domestica)
Mammalia PLA2G1B 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G1B 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G1B 34 35
  • 68.21 (n)
-- 35
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PLA2G1B 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g1b 34
  • 65.36 (n)
Str.9482 34
zebrafish
(Danio rerio)
Actinopterygii pla2g1b 34 35
  • 60.93 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9086 34
worm
(Caenorhabditis elegans)
Secernentea C07E3.9 35
  • 32 (a)
OneToMany
Species where no ortholog for PLA2G1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G1B Gene

ENSEMBL:
Gene Tree for PLA2G1B (if available)
TreeFam:
Gene Tree for PLA2G1B (if available)

Paralogs for PLA2G1B Gene

(8) SIMAP similar genes for PLA2G1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA2G1B: view

Variants for PLA2G1B Gene

Sequence variations from dbSNP and Humsavar for PLA2G1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000190054 -- 120,329,238(+) GCCTC(C/G)CAAAA upstream-variant-2KB
rs1000675828 -- 120,321,759(+) CCAGG(C/G/T)GCGGC downstream-variant-500B
rs1000808358 -- 120,328,988(+) TATAT(-/A)TTTTT upstream-variant-2KB
rs1000831627 -- 120,327,928(+) CAGCA(A/T)GGGAT upstream-variant-2KB
rs1000963775 -- 120,327,411(+) TGGAA(A/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G1B Gene

Variant ID Type Subtype PubMed ID
nsv560435 CNV loss 21841781

Variation tolerance for PLA2G1B Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G1B Gene

Disorders for PLA2G1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLA2G1B Gene - From: GeneCards

Disorder Aliases PubMed IDs
distal hereditary motor neuropathy, type ii
  • dsma2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2G1B

Genetic Association Database (GAD)
PLA2G1B
Human Genome Epidemiology (HuGE) Navigator
PLA2G1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G1B
genes like me logo Genes that share disorders with PLA2G1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G1B Gene

Publications for PLA2G1B Gene

  1. The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker. (PMID: 12759552) Rybakowski J.K. … Hauser J. (Neuropsychobiology 2003) 3 22 46 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Structural insight into the activation mechanism of human pancreatic prophospholipase A2. (PMID: 19297324) Xu W. … Liu J. (J. Biol. Chem. 2009) 3 4 64
  4. The effects of beta2 adrenergic receptor gene polymorphism in lipid profiles. (PMID: 18492292) Kao W.T. … Lung F.W. (Lipids Health Dis 2008) 3 46 64
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64

Products for PLA2G1B Gene

Sources for PLA2G1B Gene

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