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PLA2G1B Gene

protein-coding   GIFtS: 68
GCID: GC12M120759

Phospholipase A2, Group IB (Pancreas)


(Previous symbols: PLA2, PPLA2, PLA2A)
  See PLA2G1B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase A2, Group IB (Pancreas)1 2     Phosphatidylcholine 2-Acylhydrolase 1B2 3
PLA21 2 3 5     EC 3.1.1.43 8
PLA2A1 2 3 5     Phospholipase A22
PPLA21 2 3 5     Group IB Phospholipase A23

External Ids:    HGNC: 90301   Entrez Gene: 53192   Ensembl: ENSG000001708907   OMIM: 1724105   UniProtKB: P040543   

Export aliases for PLA2G1B gene to outside databases

Previous GC identifers: GC12M119633 GC12M120286 GC12M120542 GC12M119171 GC12M119222 GC12M119244 GC12M117768


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLA2G1B Gene:
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the
pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of
membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently
converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including
prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes
including cell contraction, cell proliferation and pathological response. (provided by RefSeq, Aug 2013)

GeneCards Summary for PLA2G1B Gene:
PLA2G1B (phospholipase A2, group IB (pancreas)) is a protein-coding gene. Diseases associated with PLA2G1B include distal hereditary motor neuropathy, type ii, and blepharitis. GO annotations related to this gene include phospholipase A2 activity and calcium ion binding. An important paralog of this gene is ENSG00000258417.

UniProtKB/Swiss-Prot: PA21B_HUMAN, P04054
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this
releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules

summary for PLA2G1B Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLA2G1B gene promoter:
         AP-1   ATF-2   RelA   NF-kappaB   PPAR-gamma1   c-Jun   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2G1B promoter sequence
   Search Chromatin IP Primers for PLA2G1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLA2G1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

PLA2G1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120759:  view genomic region     (about GC identifiers)

Start:
120,759,914 bp from pter      End:
120,765,592 bp from pter
Size:
5,679 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PA21B_HUMAN, P04054 (See protein sequence)
Recommended Name: Phospholipase A2 precursor  
Size: 148 amino acids; 16360 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subunit: Monomer or homodimer (By similarity). The inactive pro-form is a homotrimer
2 PDB 3D structures from and Proteopedia for PLA2G1B:
1YSK (3D)        3ELO (3D)    
Secondary accessions: B2R4H5 Q3KPI1

Explore the universe of human proteins at neXtProt for PLA2G1B: NX_P04054

Explore proteomics data for PLA2G1B at MOPED

Post-translational modifications: 

  • Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PLA2G1B (P04054) (see all 5)
     QTHDNCY  GGSGTPVD  AFICNCDR  YGCYCGLGG 


    See PLA2G1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000919.1  
    ENSEMBL proteins: 
     ENSP00000312286   ENSP00000413594   ENSP00000447233  
    Reactome Protein details: P04054

    PLA2G1B Human Recombinant Protein Products:

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    OriGene Purified Protein for PLA2G1B
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    OriGene MassSpec for PLA2G1B
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    Novus Biologicals PLA2G1B Protein
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    Sino Biological Recombinant Protein for PLA2G1B
    Sino Biological Cell Lysate for PLA2G1B
    ProSpec Recombinant Protein for PLA2G1B
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PLA2G1B 

     
    antibodies-online proteins for PLA2G1B (16 products) 

     
    antibodies-online peptides for PLA2G1B

    PLA2G1B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PLA2G1B
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    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PLA2G1B
    antibodies-online antibodies for PLA2G1B (65 products) 

    PLA2G1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PLA2G1B 
    antibodies-online kits for PLA2G1B (19 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: sPLA2-1B
    Phospholipase A2

    3 InterPro protein domains:
     IPR016090 PLipase_A2_dom
     IPR001211 PLipase_A2
     IPR013090 PLipase_A2_AS

    Graphical View of Domain Structure for InterPro Entry P04054

    ProtoNet protein and cluster: P04054

    1 Blocks protein domain: IPB001211 Phospholipase A2

    UniProtKB/Swiss-Prot: PA21B_HUMAN, P04054
    Similarity: Belongs to the phospholipase A2 family


    Find genes that share domains with PLA2G1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PA21B_HUMAN, P04054
    Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this
    releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules
    Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate

         Genatlas biochemistry entry for PLA2G1B:
    phospholipase A2,Ca2+ dependent,group 1B,pancreatic,secreted,cleaved by caspase 1 and caspase 8,for proteolysis
    and inactivation during apoptosis,inducing cell proliferation,smooth muscle contraction and lipid mediator
    release

         Enzyme Number (IUBMB): EC 3.1.1.41 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004623phospholipase A2 activity IDA1918029
    GO:0005102receptor binding IPI7721806
    GO:0005509calcium ion binding IDA7060561
    GO:0032052bile acid binding ISS7060561
    GO:0047498calcium-dependent phospholipase A2 activity IDA7060561
         
    Find genes that share ontologies with PLA2G1B           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pla2g1b):
     adipose tissue  digestive/alimentary  growth/size/body  homeostasis/metabolism  liver/biliary system 

    Find genes that share phenotypes with PLA2G1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pla2g1btm1Dyh for PLA2G1B

       genOway: Develop your customized and physiologically relevant rodent model for PLA2G1B

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PLA2G1B

    Gene Editing
    Products:
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PLA2G1B (NM_000928)
    Sino Biological Human cDNA Clone for PLA2G1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G1B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PLA2G1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PA21B_HUMAN, P04054: Secreted. Note=secreted from pancreatic acinar cells in its inactive form
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion3
    plasma membrane3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    lysosome2
    nucleus2
    vacuole2
    endosome1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA7060561
    GO:0009986cell surface IDA1918029
    GO:0030141secretory granule IEA--

    Find genes that share ontologies with PLA2G1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLA2G1B About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Synthesis of PA0.33
    Phospholipid metabolism0.64
    Acyl chain remodelling of PG0.00
    Glycerophospholipid metabolism0.62
    Acyl chain remodelling of PI0.00
    2Acyl chain remodelling of PC
    Acyl chain remodelling of PE0.85
    Ether lipid metabolism0.48
    Acyl chain remodelling of PC0.85
    Acyl chain remodelling of PS0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4phospholipases
    phospholipases0.34
    Anandamide biosynthesis and metabolism0.34
    5Arachidonic acid metabolism
    Linoleic acid metabolism0.64
    Arachidonic acid metabolism0.41
    alpha-Linolenic acid metabolism0.64


    Find genes that share SuperPaths with PLA2G1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLA2G1B (see all 12)
        Chemokine Signaling
    MIF Regulation of Innate Immune Cells
    DHA Signaling
    Endothelin-1 Signaling Pathway
    Antioxidant Action of Vitamin-C

    2 Cell Signaling Technology (CST) Pathways for PLA2G1B
        Ca, cAMP and Lipid Signaling
    Glucose / Energy Metabolism

    2 GeneGo (Thomson Reuters) Pathways for PLA2G1B
        Anandamide biosynthesis and metabolism
    Immune response CD16 signaling in NK cells

    2 BioSystems Pathways for PLA2G1B
        Fc-epsilon receptor I signaling in mast cells
    phospholipases


    Selected Reactome Pathways for PLA2G1B (see all 6)
        Acyl chain remodelling of PE
    Acyl chain remodelling of PS
    Synthesis of PA
    Acyl chain remodelling of PC
    Acyl chain remodelling of PG


    Selected Kegg Pathways  (Kegg details for PLA2G1B) (see all 10):
        Glycerophospholipid metabolism
    Ether lipid metabolism
    Arachidonic acid metabolism
    Linoleic acid metabolism
    alpha-Linolenic acid metabolism

        Pathway & Disease-focused RT2 Profiler PCR Array including PLA2G1B: 
              VEGF Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PLA2G1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLA2G1B (P040543 ENSP000003122864) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLA2G2AP145553, ENSP000003642524I2D: score=3 STRING: ENSP00000364252
    BGNP218103, ENSP000003273364I2D: score=1 STRING: ENSP00000327336
    PLAAQ9Y2633, ENSP000003804604I2D: score=1 STRING: ENSP00000380460
    CSF3RQ990623I2D: score=2 
    ALOX12ENSP000002515354STRING: ENSP00000251535
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ISS15528384
    GO:0002446neutrophil mediated immunity ISS16005851
    GO:0006633fatty acid biosynthetic process IDA1918029
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--

    Find genes that share ontologies with PLA2G1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for PLA2G1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLA2G1B (see all 2140)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    Alpha-Linolenic acid(9,12,15)-linolenate (see all 23)463-40-1--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    CalciumCa (see all 2)7440-70-2--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--

    Selected DrugBank Compounds for PLA2G1B (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine-- --target--17139284 17016423 10592235
    Hexane-1,6-Diol-- 629-11-8target--17139284 17016423 10592235
    Lpc-Ether-- --target--17139284 17016423 10592235
    P-Anisic Acid-- 100-09-4target--17139284 17016423 10592235
    Pyruvoyl Group-- --target--17139284 17016423 10592235
    Niflumic Acid2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid (see all 13)4394-00-7targetinhibitor10592235 16301791
    1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL-- --target--10592235
    Alpha-D-Mannose-- 3458-28-4target--10592235
    Cholic Acid-- 81-25-4target--10592235
    Heptanoic Acid-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PLA2G1B gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scalaradial 84.1 4 8185681 (1), 8938669 (1), 9729536 (1)
    aacocf3 81.7 12 12372807 (1), 9045886 (1), 8615870 (1), 9756383 (1)
    leukotriene b4 81.3 41 7592874 (6), 8108369 (4), 7840141 (3), 8396001 (2) (see all 13)
    manoalide 79.9 6 8737743 (2), 8496167 (1), 1324685 (1), 9522038 (1)
    arachidonic acid 79.4 53 7592874 (4), 9247974 (2), 8615870 (2), 8978280 (2) (see all 28)
    p-bromophenacyl bromide 72.8 11 8371132 (2), 8496167 (1), 8113394 (1), 1665306 (1) (see all 5)
    fmlp 71.7 5 9421281 (1), 16516193 (1), 8597589 (1), 2166499 (1)
    quinacrine 71 10 16330112 (2), 8496167 (1), 8108369 (1), 8779929 (1) (see all 9)
    bw755c 69.8 2 7840141 (1), 7993666 (1)
    5-hydroxyeicosatetraenoic acid 64.4 4 7592874 (3)



    Find genes that share compounds with PLA2G1B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLA2G1B gene: 
    NM_000928.2  

    Unigene Cluster for PLA2G1B:

    Phospholipase A2, group IB (pancreas)
    Hs.992  [show with all ESTs]
    Unigene Representative Sequence: BE969664
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308366(uc001tyd.3 uc009zwx.3) ENST00000423423 ENST00000549767

    miRNA
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    GenScript: all cDNA clones in your preferred vector: PLA2G1B (NM_000928)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G1B
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      QuantiTect SYBR Green Assays in human, mouse, rat PLA2G1B
      QuantiFast Probe-based Assays in human, mouse, rat PLA2G1B

    Additional mRNA sequence: 

    AK311830.1 BC005386.1 BC013384.1 BC106725.1 BC106726.1 M21054.1 

    1 DOTS entry:

    DT.412826 

    Selected AceView cDNA sequences (see all 74):

    AI925956 NM_000928 BU952425 BC005386 AA844966 AA921386 BQ632018 BU949426 
    BU785040 BM505143 AA366418 AI985509 BX113838 BU950978 BC013384 BG142111 
    BU071991 BU949393 CK902774 BQ271823 CA943648 BQ631720 AA366739 AW139696 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G1B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
    SP1:                              
    SP2:                    -         


    ECgene alternative splicing isoforms for PLA2G1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLA2G1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAACTGCTA
    PLA2G1B Expression
    About this image


    PLA2G1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
     
     Ovary (Reproductive System)
    PLA2G1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLA2G1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.992
        Pathway & Disease-focused RT2 Profiler PCR Array including PLA2G1B: 
              VEGF Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLA2G1B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2g1b1 , 5 phospholipase A2, group IB, pancreas1, 5 80.21(n)1
    81.25(a)1
      5 (56.10 cM)5
    187781  NM_011107.11  NP_035237.11 
     1154662625 
    chicken
    (Gallus gallus)
    Aves PLA2G1B1 phospholipase A2, group IB (pancreas) 68.21(n)
    67.69(a)
      770292  XM_001233626.3  XP_001233627.2 
    lizard
    (Anolis carolinensis)
    Reptilia PLA2G1B6
    phospholipase A2, group IB (pancreas)
    68(a)
    1 ↔ 1
    GL343338.1(18504-20361)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.94822 Transcribed sequence with weak similarity to protein more 76.4(n)    137712138 
    zebrafish
    (Danio rerio)
    Actinopterygii BM316898.12   -- 78.4(n)    BM316898.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C07E3.96
    Protein C07E3.9 (C07E3.9) mRNA, complete cds
    32(a)
    1 → many
    II(10350760-10351617) WBGene00007419


    ENSEMBL Gene Tree for PLA2G1B (if available)
    TreeFam Gene Tree for PLA2G1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLA2G1B gene
    ENSG000002584172  PLA2G2F2  PLA2G2E2  PLA2G2A2  PLA2G2D2  OC902  PLA2G102  PLA2G52  
    PLA2G2C2  
    8 SIMAP similar genes for PLA2G1B using alignment to 3 protein entries:     PA21B_HUMAN (see all proteins):
    PLA2G10    PLA2G2A    PLA2G2E    PLA2G2D    PLA2G2F    OC90
    PLA2G2C    PLA2G5

    Find genes that share paralogs with PLA2G1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLA2G1B (see all 226)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385481091,2
    --120759472(+) TGCTTA/GCTTGC 1 -- int10--------
    rs96579471,2
    C,F,H--120759551(-) ctACTC/TTGCCT 1 -- int19Minor allele frequency- T:0.01NS EA NA 1062
    rs1924432321,2
    C--120759595(+) ACTTTG/TCGAGG 1 -- int10--------
    rs93003101,2
    C,F--120759596(-) gcctcG/Acaaag 1 -- int11Minor allele frequency- A:0.02NS 172
    rs1399119571,2
    C--120759897(+) AGAATA/GAAACA 1 -- int10--------
    rs20665391,2
    C,F,H--120759929(-) GCACCT/CTGTTG 1 -- ut3111Minor allele frequency- C:0.02NA NS EA WA 1336
    rs1836122581,2
    C--120759960(+) GAGATA/GAGGCA 1 -- ut310--------
    rs1999724941,2
    --120760074(+) GCAGCA/GTTGCG 2 N syn10--------
    rs1511391121,2
    C,F--120760078(+) CGTTGC/TGGTCG 2 H R mis11Minor allele frequency- T:0.00NA 4552
    rs1494000121,2
    C--120760099(+) TGAAGC/GCCTCA 2 A G mis10--------

    HapMap Linkage Disequilibrium report for PLA2G1B (120759914 - 120765592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PLA2G1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899555CNV Loss21882294
    nsv899556CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLA2G1B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 172410    OMIM disorders: --

    4 diseases for PLA2G1B:    
    About MalaCards
    distal hereditary motor neuropathy, type ii    blepharitis    gas gangrene    acinar cell carcinoma

    7 diseases from the University of Copenhagen DISEASES database for PLA2G1B:
    Pancreatitis     Gas gangrene     Atherosclerosis     Lung disease
    Arthritis     Heart disease     Toxic encephalopathy

    Find genes that share disorders with PLA2G1B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PLA2G1B gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock septic 14.4 7 8225564 (2), 8270179 (1), 8212029 (1)
    necrosis 3.47 2 1944209 (1), 8762444 (1)
    acute pancreatitis 0.47 2 8108369 (1), 8212029 (1)
    ischemia 0 1 7791340 (1)
    schizophrenia 0 2 12759552 (1), 15999343 (1)
    shock 0 1 1787339 (1)
    pneumonia 0 2 8396001 (2)
    inflammation 0 4 7590434 (3)
    rheumatoid arthritis 0 3 8474071 (1), 1793011 (1)
    tumors 0 3 1944209 (1), 7954346 (1), 8762444 (1)

    Genetic Association Database (GAD): PLA2G1B
    Human Genome Epidemiology (HuGE) Navigator: PLA2G1B (6 documents)

    Export disorders for PLA2G1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLA2G1B gene, integrated from 10 sources (see all 191):
    (articles sorted by number of sources associating them with PLA2G1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker. (PubMed id 12759552)1, 4, 9 Rybakowski J.K....Hauser J. (Neuropsychobiology 2003)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Structural insight into the activation mechanism of human pancreatic prophospholipase A2. (PubMed id 19297324)1, 2 Xu W.... Liu J. (J. Biol. Chem. 2009)
    4. The effects of beta2 adrenergic receptor gene polymorphism in lipid profiles. (PubMed id 18492292)1, 4 Kao W.T....Lung F.W. (Lipids Health Dis 2008)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Lack of association between schizophrenia and the phospholipase-A(2) genes cPLA2 and sPLA2. (PubMed id 11353443)1, 4 Frieboes R.M....Henn F. (Am. J. Med. Genet. 2001)
    8. Lack of association between schizophrenia and a pancreatic phospholipase A-2 gene (PLA2G1B) polymorphism. (PubMed id 10551547)1, 4 Strauss J....Nimgaonkar V.L. (Psychiatr. Genet. 1999)
    9. Diversity of group types, regulation, and function of phospholipase A2. (PubMed id 8175726)1, 3 Dennis E.A. (J. Biol. Chem. 1994)
    10. Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung. (PubMed id 3028739)1, 2 Seilhamer J.J.... Johnson L.K. (DNA 1986)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5319 HGNC: 9030 AceView: PLA2G1B Ensembl:ENSG00000170890 euGenes: HUgn5319
    ECgene: PLA2G1B Kegg: 5319 H-InvDB: PLA2G1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLA2G1B Pharmacogenomics, SNPs, Pathways
    NIEHS SNPshttp://egp.gs.washington.edu/data/pla2g1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PLA2G1B gene:
    Search GeneIP for patents involving PLA2G1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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