Aliases for PLA2G16 Gene
External Ids for PLA2G16 Gene
Previous HGNC Symbols for PLA2G16 Gene
Previous GeneCards Identifiers for PLA2G16 Gene
GeneCards Summary for PLA2G16 Gene
PLA2G16 (Phospholipase A2 Group XVI) is a Protein Coding gene. Diseases associated with PLA2G16 include monofixation syndrome and abnormal retinal correspondence. Among its related pathways are Linoleic acid metabolism and Acyl chain remodelling of PC. GO annotations related to this gene include phospholipase A2 activity and phosphatidylserine 1-acylhydrolase activity. An important paralog of this gene is RARRES3.
UniProtKB/Swiss-Prot for PLA2G16 Gene
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue (By similarity). N- and O-acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity.